CLEVELAND STATE
CLEVELAND STATE
UNIVERSITY
2121 Euclid Avenue, Science Research Building Room
397
Cleveland, OH 44115
TEL: (216) 687-2451
FAX: (216) 687-9298
Web: www.csuohio.edu/chemistry
Email: [email protected]
Department of Chemistry
Michael A. Gates, Interim Chair.
Degrees Offered: B.S, M.S, Ph.D.
Fields of Specialization: Clinical/Bioanalytical
Chemistry, Physical Chemistry, Organic Chemistry,
Inorganic Chemistry, Analytical Chemistry, Clinical
Chemistry and Structural Analysis.
Interdisciplinary Program: Molecular Medicine Specialization Clinical Chemistry Specialization.
ALMASAN, ALEXANDRU (b.1954) Cleveland
Clinic Associate Professor. M.S, 1979, University of
Brasov; Ph.D, 1989, University of South Carolina. Research Associate, 1990-1994, Salk Institute. Molecular
Biology. Cellular response to DNA damage: Ionizing radiation-induced genes; Mechanisms of activation of
apoptosis; Role of cell cycle regulators, checkpoints, oncogenes, and tumor supressor genes in cell survival or
death (apoptosis or autophagy); Apo2L/TRAIL: Mediator of cell death. TEL: (216) 444-9970 FAX: (216) 4456269
Web: www.lerner.ccf.org/cancerbio/almasan/
Email: [email protected]
Dragos Plesca, Meredith E. Crosby, Damodar Gupta and
Alexandru Almasan, E2F4 function in G2. Maintaining G2 arrest to prevent mitotic entry with damaged DNA, Cell Cycle,
6, 1147-1152 (2007).
Suparna Mazumder, Dragos Plesca and Alexandru Almasan, A Jekyll and Hyde role of cyclin E in the genotoxic
stress response: Switching from cell cycle control to apoptosis regulation, Cell Cycle, 6, 1437-1442 (2007).
Subrata Ray, Sunitha Shyam, Gail C. Fraizer and Alexandru Almasan, S-phase checkpoints regulate Apo2 ligand/
TRAIL and CPT-11-induced apoptosis of prostate cancer
cells, Mol. Cancer Ther, 6, 1368-1378 (2007).
Suparna Mazumder, Dragos Plesca, Michael Kinter and
Alexandru Almasan, Interaction of a cyclin E fragment with
Ku70 regulates Bax-mediated apoptosis, Mol. Cell. Biol, 27,
3511-3520 (2007).
Damodar Gupta, Meredith E. Crosby, Alexandru Almasan
and Roger M. Macklis, Regulation of CD20 expression by
radiation-induced changes in intracellular redox status, Free
Radical Biol. Med, 44, 614-623 (2008).
D. Plesca, S. Mazumder, V. Gama, S. Matsuyama and A.
Almasan, A C-terminal fragment of Cyclin E, generated by
caspase-mediated cleavage, is degraded in the absence of a
recognizable phosphodegron, J Biol Chem, 283, 30796-803
(2008).
Suparna Mazumder, Dragos Plesca and Alexandru Almasan, Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis, Methods Mol. Biol. (Totowa, NJ,
U. S.), 414, 13-21 (2008).
M. Oancea, Role of Bcl-2 family of apoptotic regulatory
proteins in the genotoxic stress response. (D)
ANDERSON, DAVID JEFFREY (b.1955) Professor, Associate Dean, Director of Clinical Chemistry. B.S,
1977, Bucknell University; Ph.D, 1986, Iowa State University. Clinical Chemistry Fellowship, 1987-1988,
Mayo Clinic. Analytical Chemistry; Clinical Chemistry.
HPLC and mass spectrometry in protein analysis and
proteomics; Gradient chromatofocusing. TEL: (216)
687-5580 FAX: (216) 687-5549
Web: facultyprofile.csuohio.edu/csufacultyprofile/detail.
cfm?FacultyID=D_ANDERSON
Email: [email protected]
T. L. Sahley, C. L. Chernicky and D. J. Anderson, Bi-phasic intensity-dependent opioid-mediated neural amplitude
changes in the chinchilla cochlea: Partial blockade by an NMethyl-D-Aspartate (NMDA)-receptor antagonist, Eur J
Pharm, 580, 100-115 (2008).
L. Shan, X. Zhou, J. A. Hribar and D. J. Anderson, Gradient chromatofocusing—mass spectrometry: A new technique
in protein analysis, J Am Soc Mass Spectrom, 19, 1132-1137
(2008).
BALL, DAVID W. Professor. B.S, 1983, Baylor University; M.A, 1986, Rice University; Ph.D, 1987, Rice
University. Postdoctoral Fellow, 1987-1988, Rice University; Postdoctoral Fellow, 1988-1990, University of
California, Berkeley, Lawrence Berkeley Laboratory.
Physical Chemistry. Theoretical calculations on transient
species, molecular complexes, and high-energy molecules; various topics in chemical education. TEL: (216)
687-2456 FAX: (216) 687-9298
Web: academic.csuohio.edu/ball
Email: [email protected]
David W. Ball, The chemical composition of honey, J.
Chem. Educ, 84, 1643-1646 (2007).
David W. Ball, The chemical composition of maple syrup,
J. Chem. Educ, 84, 1647-1650 (2007).
Ryan M. Richard and David W. Ball, G2, G3, and complete basis set calculations of the thermodynamic properties
of small beryllium molecules, J. Undergrad. Chem. Res, 6,
129-138 (2007).
David W. Ball, The baseline. The electromagnetic spectrum: A history, Spectroscopy (Duluth, MN, U. S.), 22, 14,
16, 18, 20 (2007).
David W. Ball, Light-emitting diodes, Spectroscopy (Duluth, MN, U. S.), 22, 14, 16-18 (2007).
David W. Ball, Atomic clocks: an application of spectroscopy, Spectroscopy (Duluth, MN, U. S.), 22, 14, 16-18, 20
(2007).
David W. Ball, The baseline fire and flames, Spectroscopy
(Duluth, MN, U. S.), 22, 16-18 (2007).
Ryan M. Richard and David W. Ball, Optimized geometries, vibrational frequencies, and thermochemical properties
of mixed boron- and nitrogen-containing three-membered
rings, THEOCHEM, 806, 113-120 (2007).
Ryan M. Richard and David W. Ball, G2, G3, and complete basis set calculations of optimized geometries, vibrational frequencies, and thermodynamic properties of azatriboretidine and triazaboretidine, THEOCHEM, 806, 165-170
(2007).
Ryan M. Richard and David W. Ball, G2, G3, and complete basis set calculations of the thermodynamic properties
of aminoborane, diaminoborane, and triaminoborane, THEOCHEM, 823, 6-15 (2007).
Amy J. Tricamo, Karen J. Knaus and David W. Ball, G2,
G3, and complete basis set calculations of the thermodynamic properties of two isomers of diazadiboretidine, cycloB2N2H4, THEOCHEM, 807, 67-72 (2007).
Ryan M. Richard and David W. Ball, B3LYP, G2, G3, and
complete basis set calculations of the thermodynamic properties of small cyclic and chain hydroboranes, THEOCHEM,
814, 91-98 (2007).
Ryan M. Richard and David W. Ball, G2, G3, and complete basis set calculations of the thermodynamic properties
of cis- and trans-triazene, J. Mol. Model, 14, 21-27 (2008).
Ryan M. Richard and David W. Ball, G2, G3, and complete basis set calculations on the thermodynamic properties
of triazane, J. Mol. Model, 14, 29-37 (2008).
Ryan M. Richard and David W. Ball, Ab Initio Calculations on the Thermodynamic Properties of Azaspiropentanes,
J. Phys. Chem. A, 112, 2618-2627 (2008).
David W. Ball, Hexacyclo[7.1.0.01,3.03,5.05,7.07,9]decane, or
pentagramane: high-level computational studies on a novel
hydrocarbon, J. Phys. Org. Chem, 21, 387-392 (2008).
David W. Ball, Spectroscopy is applied quantum mechanics, part IV: ideal systems, Spectroscopy (Duluth, MN, U. S.),
23, 14-16, 18-21 (2008).
David W. Ball, The baseline fire and flames. [Erratum to
document cited in CA148:057605], Spectroscopy (Duluth,
MN, U. S.), 23, 17 (2008).
David W. Ball, The baseline spectroscopy is applied quantum mechanics, Part II: The quantum revolution, Spectroscopy (Duluth, MN, U. S.), 23, 18, 20, 22 (2008).
Sara L. Brunswick and David W. Ball, Organic chlorate
and perchlorate derivatives as high energy materials: Highlevel computations on methyl chlorate and methyl perchlorate, THEOCHEM, 866, 1-4 (2008).
Ryan M. Richard and David W. Ball, Ab initio calculations
on the thermodynamic properties of spiropentane and its boron-containing derivatives, THEOCHEM, 851, 284-293
(2008).
Kelly Y. Mathews and David W. Ball, New potential high
energy materials: High-level calculations on the properties of
aminonitromethanes, THEOCHEM, 868, 78-81 (2008).
Ryan M. Richard and David W. Ball, Enthalpies of formation of nitrobuckminsterfullerenes: Extrapolation to
C60(NO2)60, THEOCHEM, 858, 85-87 (2008).
BANERJEE, SIPRA CCF Assistant Professor. B.S,
1958, Presidency College, Calcutta, India; M.S, 1960,
Calcutta University, Calcutta, India; Ph.D, 1965, Calcutta University, College of Science and Technology, Calcutta, India. TEL: (216) 444-0631 FAX: (216) 444-0512
Email: [email protected]
Publication list has not been verified by the department.
Thangaiyan Rabi, Liming Wang and Sipra Banerjee, Novel
triterpenoid 25-hydroxy-3-oxoolean-12-en-28-oic acid induces growth arrest and apoptosis in breast cancer cells,
Breast Cancer Res. Treat, 101, 27-36 (2007).
Liming Wang, Nandan Bhattacharyya, Thangaiyan Rabi,
Li Wang and Sipra Banerjee, Mammary carcinogenesis in
transgenic mice expressing a dominant-negative mutant of
DNA polymerase ␤ in their mammary glands, Carcinogenesis, 28, 1356-1363 (2007).
Thangaiyan Rabi and Sipra Banerjee, Novel synthetic triterpenoid methyl 25-hydroxy-3-oxoolean-12-en-28-oate in-
1
duces apoptosis through JNK and p38 MAPK pathways in
human breast adenocarcinoma MCF-7 cells, Mol. Carcinog,
47, 415-423 (2008).
BAYACHOU, MEKKI (b.1967) Associate Professor.
B.S, 1990, University of Fez, Morocco; M.S, 1991, University of Paris, France; Ph.D, 1995, University of ParisVI and ENS, France. Postdoctoral Researcher, 19961998, University of California, Irvine; Research Associate, 1998-2000, University of California, Irvine; Visiting Asst. Professor, 2000-2001, University of Padova,
Italy. Analytical Chemistry; Bioanalytical Chemistry.
Bioelectrochemistry provides important insights on
mechanistic, kinetic, and structure-function issues. Current Metalloproteins/enzymes of interest in our labs include cytochromes P450 such as the important enzyme,
nitric oxide synthase, as well as flavodoxins and hydrogenases. We are also developing electrochemical and
spectroelectrochemical methods to investigate DNA/
small molecule and DNA/protein interactions both for
fundamental aspects and sensor development. TEL:
(216) 875-9716 FAX: (216) 687-9298
Web: www.csuohio.edu/cos/
Email: [email protected]
No publication information submitted for this edition.
BERKNER, KATHLEEN (b.1950) CCF Associate
Professor. B.Sc, 1972, University of Minnesota; D.Phil,
1977, University of Michigan. Postdoctoral Associate,
1978-1982, M. I. T. Biochemistry. Area of general research interest: Hemostasis, vitamin K dependent proteins, carboxylation; Current program: Carboxylation of
vitamin K dependent proteins. TEL: (216) 445-9760
FAX: (216) 444-9263
Web: www.lerner.ccf.org/moleccard/berkner/
Email: [email protected]
No publication information submitted for this edition.
CASEY, GRAHAM (b.1953) CCF Associate Professor. B.S, 1975, Manchester University; Ph.D, 1978, University College London. Postdoctoral Fellow, 1978, Royal Marsden Hospital; Visiting Fellow, 1985, University
of California, Irvine. Molecular biology and molecular
genetics of cancer, somatic cell genetics analysis of tumor suppressor gene function. TEL: (216) 445-9754
FAX: (216) 445-0610
Email: [email protected]
Publication list has not been verified by the department.
Iona Cheng, Lisa M. Krumroy, Sarah J. Plummer, Graham
Casey and John S. Witte, MIC1 and IL1RN genetic variation
and advanced prostate cancer risk, Cancer Epidemiol., Biomarkers Prev, 16, 1309-1311 (2007).
Iona Cheng, Sarah J. Plummer, Graham Casey and John S.
Witte, Toll-Like Receptor 4 Genetic Variation and Advanced
Prostate Cancer Risk, Cancer Epidemiol., Biomarkers Prev,
16, 352-355 (2007).
Jenny N. Poynter, Jane C. Figueiredo, David V. Conti,
Kathleen Kennedy, Steven Gallinger, Kimberly D. Siegmund, Graham Casey, Stephen N. Thibodeau, Mark A. Jenkins, John L. Hopper, Graham B. Byrnes, John A. Baron, Ellen L. Goode, Maarit Tiirikainen, Noralane Lindor, John
Grove, Polly Newcomb, Jeremy Jass, Joanne Young, John D.
Potter, Robert W. Haile, David J. Duggan and Loic Le Marchand, Variants on 9p24 and 8q24 Are Associated with Risk
of Colorectal Cancer: Results from the Colon Cancer Family
Registry, Cancer Res, 67, 11128-11132 (2007).
Steven Sizemore, Muzaffer Cicek, Nywana Sizemore,
Kwok Peng Ng and Graham Casey, Podocalyxin increases
the aggressive phenotype of breast and prostate cancer cells
in vitro through its interaction with ezrin, Cancer Res, 67,
6183-6191 (2007).
Xin Liu, Fredrick R. Schumacher, Sarah J. Plummer, Eric
Jorgenson, Graham Casey and John S. Witte, trans-Fatty acid
intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variant, Carcinogenesis, 28,
1232-1236 (2007).
Bon-Hun Koo, Tiina Hurskainen, Katrina Mielke, Phyu
Phyu Aung, Graham Casey, Helena Autio-Harmainen and
Suneel S. Apte, ADAMTSL3/punctin-2, a gene frequently
mutated in colorectal tumors, is widely expressed in normal
and malignant epithelial cells, vascular endothelial cells and
other cell types, and its mRNA is reduced in colon cancer,
Int. J. Cancer, 121, 1710-1716 (2007).
Zhenwen Zhao, Yijin Xiao, Paul Elson, Haiyan Tan, Sarah
J. Plummer, Michael Berk, Phyu P. Aung, Ian C. Lavery,
Jean P. Achkar, Li Li, Graham Casey and Yan Xu, Plasma
lysophosphatidylcholine levels: potential biomarkers for colorectal cancer, J. Clin. Oncol, 25, 2696-2701 (2007).
Rajeev S. Samant, David W. Clark, Rebecca A. Fillmore,
Muzaffer Cicek, Brandon J. Metge, Kondethimmana H.
Chandramouli, Ann F. Chambers, Graham Casey, Danny R.
Welch and Lalita A. Shevde, Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-Kappa B activation, Mol. Cancer, 6, No pp. given (2007).
Ryuichi Fukuyama, Kwok Peng Ng, Muzaffer Cicek, Clare
Kelleher, Roxana Niculaita, Graham Casey and Nywana
2
CLEVELAND STATE
Sizemore, Role of IKK and oscillatory NF␬B kinetics in
MMP-9 gene expression and chemoresistance to 5-fluorouracil in RKO colorectal cancer cells, Mol. Carcinog, 46, 402413 (2007).
Li Li, Sarah J. Plummer, Cheryl L. Thompson, Alona Merkulova, Louise S. Acheson, Thomas C. Tucker and Graham
Casey, A Common 8q24 Variant and the Risk of Colon Cancer: A Population-Based Case-Control Study, Cancer Epidemiol., Biomarkers Prev, 17, 339-342 (2008).
Heather M. Ochs-Balcom, Mine S. Cicek, Cheryl L.
Thompson, Thomas C. Tucker, Robert C. Elston, Sarah J.
Plummer, Graham Casey and Li Li, Association of vitamin D
receptor gene variants, adiposity and colon cancer, Carcinogenesis, 29, 1788-1793 (2008).
Li Li, Sarah J. Plummer, Cheryl L. Thompson, Thomas C.
Tucker and Graham Casey, Association between Phosphatidylinositol 3-Kinase Regulatory Subunit p85␣ Met326Ile
Genetic Polymorphism and Colon Cancer Risk, Clin. Cancer
Res, 14, 633-637 (2008).
Iona Cheng, Sarah J. Plummer, Eric Jorgenson, Xin Liu,
Benjamin A. Rybicki, Graham Casey and John S. Witte,
8q24 and prostate cancer: association with advanced disease
and meta-analysis, Eur. J. Hum. Genet, 16, 496-505 (2008).
Benjamin D. Hedley, Danny R. Welch, Alison L. Allan,
Waleed Al-Katib, David W. Dales, Carl O. Postenka, Graham Casey, Ian C. MacDonald and Ann F. Chambers, Downregulation of osteopontin contributes to metastasis suppression by breast cancer metastasis suppressor 1, Int. J. Cancer,
123, 526-534 (2008).
Kedar S. Vaidya, Sitaram Harihar, Pushkar A. Phadke,
Lewis J. Stafford, Douglas R. Hurst, David G. Hicks, Graham Casey, Daryll B. DeWald and Danny R. Welch, Breast
Cancer Metastasis Suppressor-1 Differentially Modulates
Growth Factor Signaling, J. Biol. Chem, 283, 28354-28360
(2008).
Yuqiu Jiang, Graham Casey, Ian C. Lavery, Yi Zhang,
Dmitri Talantov, Michelle Martin-McGreevy, Marek Skacel,
Elena Manilich, Abhijit Mazumder, David Atkins, Conor P.
Delaney and Yixin Wang, Development of a clinically feasible molecular assay to predict recurrence of stage II colon
cancer, J. Mol. Diagn, 10, 346-354 (2008).
Benjamin T. Larson, Cristina Magi-Galluzzi, Graham Casey, Sarah J. Plummer, Robert Silverman and Eric A. Klein,
Pathological aggressiveness of prostatic carcinomas related
to RNASEL R462Q allelic variants, J. Urol. (N. Y., NY, U.
S.), 179, 1344-1348 (2008).
CATHCART, MARTHA KIMBALL (b.1951) CCF
Professor. B.A, 1974, Denison University; Ph.D, 1979,
Case Western Reserve University. Postdoctoral Fellow,
1978-1980, Cleveland Clinic Foundation. TEL: (216)
444-5222 FAX: (216) 444-9404
Web: www.lerner.ccf.org/cellbio/cathcart/
Email: [email protected]
Email: [email protected]
Unni M. Chandrasekharan, Lori Mavrakis, Jonathan D.
Smith, Paul E. DiCorleto and Tracy L. Bonfield, Decreased
atherosclerosis in mice deficient in tumor necrosis factor-␣
receptor-II (p75), Arterioscler., Thromb., Vasc. Biol, 27, e16e17 (2007).
Unni M. Chandrasekharan, Maria Siemionow, Murat Unsal, Lin Yang, Earl Poptic, Justin Bohn, Kagan Ozer, Zhongmin Zhou, Philip H. Howe, Marc Penn and Paul E. DiCorleto, Tumor necrosis factor ␣ (TNF-␣) receptor-II is required
for TNF-␣-induced leukocyte-endothelial interaction in vivo,
Blood, 109, 1938-1944 (2007).
Smarajit Bandyopadhyay, Mohammad Z. Ashraf, Pamela
Daher, Philip H. Howe and Paul E. DiCorleto, HOXA9 participates in the transcriptional activation of E-selectin in endothelial cells, Mol. Cell. Biol, 27, 4207-4216 (2007).
Corttrell M. Kinney, Unni M. Chandrasekharan, Lori Mavrakis and Paul E. DiCorleto, VEGF and thrombin induce
MKP-1 through distinct signaling pathways: role for MKP-1
in endothelial cell migration, Am. J. Physiol, 294, C241C250 (2008).
Jianzhong Shen and Paul E. DiCorleto, ADP stimulated
human endothelial cell migration via P2Y1 Nucleotide Receptor-Mediated Mitogen-Activated Protein Kinase Pathways, Circ. Res, 102, 448-456 (2008).
DIDONATO, JOSEPH CCF Assistant Professor.
B.A, 1980, Hiram College; M.S, 1983, University of Akron; Ph.D, 1990, The Ohio State University. Visiting Scientist, 1990, The Ohio State University; Post Doctoral
Fellow, 1990-1998, University of California at San Diego. Biochemistry; Molecular Biology. Proinflammatory
signal transduction concentrating on the IKapa B kinase
and NF-kB signaling pathways and mechanistic modes
of their activation by the cytokines TNF and IL-1 and information feeding into it via the Toll-like receptors.
TEL: (216) 444-8178 FAX: (216) 445-6269
Email: [email protected]
Publication list has not been verified by the department.
Aicha Saadane, Sophia Masters, Joseph DiDonato, Jingfeng Li and Melvin Berger, Parthenolide inhibits I␬B kinase,
NF-␬B activation, and inflammatory response in cystic fibrosis cells and mice, Am. J. Respir. Cell Mol. Biol, 36, 728-736
(2007).
Jianhong Yao, Tae Whan Kim, Jinzhong Qin, Zhengfan
Jiang, Youcun Qian, Hui Xiao, Yi Lu, Wen Qian, Muhammet Fatih Gulen, Nywana Sizemore, Joseph DiDonato, Shintaro Sato, Shizuo Akira, Bing Su and Xiaoxia Li, Interleukin1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NF␬B Activation Pathways Bifurcate at IL-1 Receptorassociated Kinase Modification, J. Biol. Chem, 282, 60756089 (2007).
No publication information submitted for this edition.
CHISOLM, GUY M., III (b.1946) CCF Professor.
B.S, 1968, University of Pennsylvania; Ph.D, 1972, University of Virginia. Postdoctoral Fellow, 1972-1973, Karolinska Institute, Stockholm; Research Associate, 19731975, Massachusetts Institute of Technology. Cell Biology. Vascular biology, lipoprotein-cell interactions, lipoprotein oxidation, atherosclerosis, apoptosis. TEL: (216)
444-5854 FAX: (216) 444-3279
Web: www.lerner.ccf.org/cellbio/chisolm/
Email: [email protected]
No publication information submitted for this edition.
CRABB, JOHN W. (b.1948) CCF Professor. Ph.D,
1978, University of Kansas. Postdoctoral Scholar, 19781980, Dept Biological Chemistry, University of Michigan; Sr Fellow, 1980-1982, Dept of Ophthalmology,
University of Washington. We seek a better understanding of the biochemistry of vision in two areas: Visual
Cycle proteins such as CRALBP involved in the regeneration of 11-cis-retinal; and proteomic approaches to retinal degenerative diseases such as age-related macular degeneration. TEL: (216) 445-0425 FAX: (216) 445-3670
Web: www.lerner.ccf.org/eye/crabb/
Email: [email protected]
No publication information submitted for this edition.
DICORLETO, PAUL E. (b.1951) CCF Professor.
B.S, 1973, Rensselaer Polytechnic Institute; Ph.D, 1978,
Cornell University. Postdoctoral Fellow, 1978-1981,
University of Washington. Biochemistry; Cell Biology.
Our central objective is to understand the role of endothelial cells (EC) in the physiology and pathology of
blood vessels. We are pursuing three areas. The first is
the regulation of expression of leukocyte adhesion molecules by the EC in response to thrombin and cytokines.
The second area is the role of the homeobox transcription factor HOXA9 in EC activation, and the third is elucidating the role of the protein phosphatase MKP-1 in
EC gene expression changes in response to TNF and
VEGF. TEL: (216) 444-5849 FAX: (216) 444-3279
Web: www.lerner.ccf.org/cellbio/dicorleto/
DRISCOLL, DONNA MARIE (b.1953) CCF Associate Professor. B.S, 1974, Purdue University; M.S,
1976, University of Wisconsin, Madison; Ph.D, 1984,
University of Chicago. Postdoctoral Fellow, 1984-1987,
Imperial Cancer Res. Fund; Nonclinical Scientist, 19871989, MRC Clinical Research Centre. Molecular Biology. Molecular biology; post transcriptional gene regulation; selenoprotein biosynthesis; RNA-protein interactions; selenium metabolism. TEL: (216) 445-9758 FAX:
(216) 444-9404
Email: [email protected]
J. L. Bubenik and D. M. Driscoll, Altered RNA-binding
activity underlies abnormal thyroid hormone metabolism
linked to a mutation in Sec insertion sequence binding protein, Journal of Biological Chemistry, 282, 34653-34662
(2007).
DURAJ, STAN A. Professor. B.S, 1973, Jagiellonian
University; M.S, 1973, Jagiellonian University; Ph.D,
1980, Southern Illinois University. Research Associate,
1980-1982, Southern Illinois University; Research Associate, 1983-1985, Texas A & M University. Inorganic
Chemistry; Organometallic Chemistry. Reactivity and
synthesis of multiple metal-metal bonds. Reactivity and
synthesis of gallium and indium compounds as well as
polyaromatic and polyheteroaromatic transition metal
complexes. TEL: (216) 687-2454 FAX: (216) 687-9298
Email: [email protected]
No publication information submitted for this edition.
ERZURUM, SERPIL CEMILE (b.1959) CCF Professor. B.S, 1983, Youngstown State University; M.D,
1983, Northeastern Ohio University. Internal Medicine
Residency, 1983-1986, Baylor College of Medicine; Pulmonary/Critical Care Fellowship, 1987-1990, University
of Colorado Health Science; Senior Staff Fellow, 19901992, NHLBI—NIH. Cell Biology; Molecular Biology.
Our group has conducted research in the field of nitric
oxide, reactive oxygen species and antioxidants in the
lung for over 10 y. We have helped to formulate the current understanding of NO biosynthesis and the regulation
of antioxidants in the lung, and their functions in inflam-
mation, host defense and pulmonary vasoregulation.
TEL: (216) 445-7191 FAX: (216) 445-6269
Email: [email protected]
No publication information submitted for this edition.
FEBBRAIO, MARIA Associate Professor. B.S, 1982,
Fordham University; Ph.D, 1990, Cornell University
Medical College, Graduate School of Medical Sciences.
Post Doctoral Fellow, 1990-1993, Rockefeller University; Post Doctoral Fellow, 1994-1996, Cornell University
Medical College. Cell Biology; Molecular Biology. My
research centers around a scavenger receptor and fatty
acid transporter, CD36. We are interested in its role in
atherosclerosis, diabetes and angiogenesis. We use
mouse models and cell based assays to explore the multiple functions of CD36 at the cellular and molecular level.
We are particularly interested in how CD36 may control
metabolic processes because it is expressed on muscle,
fat, endothelial cells and macrophages. TEL: (216) 4455605 FAX: (216) 444-9404
Web: www.lerner.ccf.org/cellbio/febbraio/
Email: [email protected]
Publication list has not been verified by the department.
Arend Bonen, Xiao-Xia Han, Daphna D. J. Habets, Maria
Febbraio, Jan F. C. Glatz and Joost J. F. P. Luiken, A null
mutation in skeletal muscle FAT/CD36 reveals its essential
role in insulin- and AICAR-stimulated fatty acid metabolism,
Am. J. Physiol, 292, E1740-E1749 (2007).
Kristen L. King, William C. Stanley, Mariana Rosca, Janos
Kerner, Charles L. Hoppel and Maria Febbraio, Fatty acid
oxidation in cardiac and skeletal muscle mitochondria is
unaffected by deletion of CD36, Arch. Biochem. Biophys,
467, 234-238 (2007).
Ella Guy, Sai Kuchibhotla, Roy Silverstein and Maria Febbraio, Continued inhibition of atherosclerotic lesion development in long term Western diet fed CD36°/apoE° mice, Atherosclerosis (Amsterdam, Neth.), 192, 123-130 (2007).
Daphna D. J. Habets, Will A. Coumans, Peter J. Voshol,
Marion A. M. den Boer, Maria Febbraio, Arend Bonen, Jan
F. C. Glatz and Joost J. F. P. Luiken, AMPK-mediated increase in myocardial long-chain fatty acid uptake critically
depends on sarcolemmal CD36, Biochem. Biophys. Res.
Commun, 355, 204-210 (2007).
John Yang, Nandakumar Sambandam, Xianlin Han, Richard W. Gross, Michael Courtois, Attila Kovacs, Maria Febbraio, Brian N. Finck and Daniel P. Kelly, CD36 Deficiency
Rescues Lipotoxic Cardiomyopathy, Circ. Res, 100, 12081217 (2007).
Debby P. Y. Koonen, Maria Febbraio, Sebastien Bonnet,
Jayan Nagendran, Martin E. Young, Evangelos D. Michelakis and Jason R. B. Dyck, CD36 Expression Contributes to
Age-Induced Cardiomyopathy in Mice, Circulation, 116,
2139-2147 (2007).
Sudesh Agrawal, Maria Febbraio, Eugene Podrez, Martha
K. Cathcart, George R. Stark and Guy M. Chisolm, Signal
Transducer and Activator of Transcription 1 Is Required for
Optimal Foam Cell Formation and Atherosclerotic Lesion
Development, Circulation, 115, 2939-2947 (2007).
Roy L. Silverstein and Maria Febbraio, CD36-TSP-HRGP
interactions in the regulation of angiogenesis, Curr. Pharm.
Des, 13, 3559-3567 (2007).
Debby P. Y. Koonen, Rene L. Jacobs, Maria Febbraio,
Martin E. Young, Carrie-Lynn M. Soltys, Huy Ong, Dennis
E. Vance and Jason R. B. Dyck, Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity, Diabetes, 56, 2863-2871 (2007).
Maria Febbraio and Roy L. Silverstein, CD36: Implications in cardiovascular disease, Int. J. Biochem. Cell Biol, 39,
2012-2030 (2007).
Mary Jane Thomassen, Barbara P. Barna, Achut G. Malur,
Tracey L. Bonfield, Carol F. Farver, Anagha Malur, Heidi
Dalrymple, Mani S. Kavuru and Maria Febbraio, ABCG1 is
deficient in alveolar macrophages of GM-CSF knockout
mice and patients with pulmonary alveolar proteinosis, J.
Lipid Res, 48, 2762-2768 (2007).
Margarida Cunha-Rodrigues, Silvia Portugal, Maria Febbraio and Maria M. Mota, Bone marrow chimeric mice reveal a dual role for CD36 in Plasmodium berghei ANKA infection, Malar. J, 6, No pp. given (2007).
Eugene A. Podrez, Tatiana V. Byzova, Maria Febbraio,
Robert G. Salomon, Yi Ma, Manojkumar Valiyaveettil, Eugenia Poliakov, Mingjiang Sun, Paula J. Finton, Brian R.
Curtis, Juhua Chen, Renliang Zhang, Roy L. Silverstein and
Stanley L. Hazen, Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype, Nat. Med. (N. Y.,
NY, U. S.), 13, 1086-1095 (2007).
Manojkumar Valiyaveettil, Niladri Kar, Mohammad Z.
Ashraf, Tatiana V. Byzova, Maria Febbraio and Eugene A.
Podrez, Oxidized high-density lipoprotein inhibits platelet
activation and aggregation via scavenger receptor BI, Blood,
111, 1962-1971 (2008).
Sai Kuchibhotla, Difernando Vanegas, David J. Kennedy,
Ella Guy, George Nimako, Richard E. Morton and Maria
Febbraio, Absence of CD36 protects against atherosclerosis
in ApoE knock-out mice with no additional protection provided by absence of scavenger receptor A I/II, Cardiovasc.
Res, 78, 185-196 (2008).
Kan Chen, Maria Febbraio, Wei Li and Roy L. Silverstein,
A Specific CD36-Dependent Signaling Pathway Is Required
CLEVELAND STATE
for Platelet Activation by Oxidized Low-Density Lipoprotein, Circ. Res, 102, 1512-1519 (2008).
Jie Zhou, Maria Febbraio, Taira Wada, Yonggong Zhai,
Ramalinga Kuruba, Jinhan He, Jung Hoon Lee, Shaheen
Khadem, Songrong Ren, Song Li, Roy L. Silverstein and
Wen Xie, Hepatic fatty acid transporter Cd36 is a common
target of LXR, PXR, and PPAR␥ in promoting steatosis,
Gastroenterology, 134, 556-567 (2008).
Mohammad Z. Ashraf, Niladri S. Kar, Xi Chen, Jaewoo
Choi, Robert G. Salomon, Maria Febbraio and Eugene A. Podrez, Specific Oxidized Phospholipids Inhibit Scavenger Receptor BI-mediated Selective Uptake of Cholesteryl Esters, J.
Biol. Chem, 283, 10408-10414 (2008).
Arunima Ghosh, Wei Li, Maria Febbraio, Ricardo G. Espinola, Keith R. McCrae, Erin Cockrell and Roy L. Silverstein,
Platelet CD36 mediates interactions with endothelial cell-derived microparticles and contributes to thrombosis in mice, J.
Clin. Invest, 118, 1934-1943 (2008).
Eunhee Kim, Aaron T. Tolhurst, Lu Ye Qin, Xin-Yuan
Chen, Maria Febbraio and Sunghee Cho, CD36/fatty acid
translocase, an inflammatory mediator, is involved in hyperlipidemia-induced exacerbation in ischemic brain injury, J.
Neurosci, 28, 4661-4670 (2008).
FOX, PAUL L. (b.1948) CCF Associate Professor.
B.S, 1969, Cornell University; Ph.D, 1983, Cornell University. NIH Fellowship, 1982-1983, National Institutes
of Health. Structure and function of ceruloplasmin, iron
metabolism, atherosclerosis, cell motility, cellular effects
of microgravity. TEL: (216) 444-8053 FAX: (216) 4449404
Email: [email protected]
Publication list has not been verified by the department.
Dola Das, Nisha Tapryal, Shyamal K. Goswami, Paul L.
Fox and Chinmay K. Mukhopadhyay, Regulation of ceruloplasmin in human hepatic cells by redox active copper: identification of a novel AP-1 site in the ceruloplasmin gene, Biochem. J, 402, 135-141 (2007).
Paul L. Fox, Partho S. Ray, Abul Arif and Jie Jia, Noncanonical functions of aminoacyl-tRNA synthetases in translational control, Cold Spring Harbor Monogr. Ser, 48, 829-853
(2007).
Partho Sarothi Ray and Paul L. Fox, A post-transcriptional
pathway represses monocyte VEGF-A expression and angiogenic activity, EMBO J, 26, 3360-3372 (2007).
Purvi Kapasi, Sujan Chaudhuri, Keyur Vyas, Diane Baus,
Anton A. Komar, Paul L. Fox, William C. Merrick and Barsanjit Mazumder, L13a blocks 48S assembly: role of a general initiation factor in mRNA-specific translational control,
Mol. Cell, 25, 113-126 (2007).
Partho Sarothi Ray, Abul Arif and Paul L. Fox, Macromolecular complexes as depots for releasable regulatory proteins, Trends Biochem. Sci, 32, 158-164 (2007).
Jie Jia, Abul Arif, Partho S. Ray and Paul L. Fox, WHEP
domains direct noncanonical function of glutamyl-prolyl
tRNA synthetase in translational control of gene expression,
Mol. Cell, 29, 679-690 (2008).
GANAPATHI, RAM (b.1950) CCF Professor. B.S,
1971, Andhra University, India; M.S, 1973, Andhra University, India; Ph.D, 1977, Massachusetts College of
Pharmacy. Research Associate, 1977, Dana Farber Cancer Institute; Research Associate, 1977-1979, Cancer
Center, University of Miami School of Medicine. Biochemistry; Pharmacology. Drug Resistance—Molecular
mechanisms of tumor cell resistance to anti-tumor drugs;
Topoisomerases I and II—Expression, regulation and
site-specific phosphorylation: In wild-type and drug resistant tumor cells; and during cell differentiation; Cell
Death—Signaling pathways regulating anti-tumor drug
induced apoptosis; and Clinical Pharmacology—Phase I
and Phase II clinical trials of novel anti-tumor agents.
TEL: (216) 444-2085 FAX: (216) 444-7115
Email: [email protected]
Saubhik Sengupta, Chad M. Michener, Pedro Escobar, Jerome Belinson and Ram Ganapathi, Ovarian cancer immunoreactive antigen domain containing 1 (OCIAD1), a key player in ovarian cancer cell adhesion, Gynecol. Oncol, 109, 226233 (2008).
T. K. Choueiri, S. A. Vaziri, E. Jaeger, P. Elson, L. Wood,
I. P. Bhalla, E. J. Small, V. Weiberg, N. Sein, J. Simko, A.R. Golshayan, L. Sercia, M. Zhou, F. M. Waldman, B. I.
Rini, R. M. Bukowski and R. Ganapathi, Von Hippel Lindau
gene status and response to vascular endothelial growth factor (VEGF) – targeted therapy in metastatic renal cell carcinoma, J. Urology, 180, 860-865; 865-866 (2008).
GATES, MICHAEL A.
No publication information submitted for this edition.
GOGONEA, VALENTIN (b.1956) Associate Professor. M.S, 1982, Polytechnical Institute of Timisoara;
Ph.D, 1996, Toyohashi University of Technology. Research associate, 1996-1997, Erlangen-Nuernberg University; Research associate, 1998-2000, Pennsylvania
State University. Biophysics/Biophysical Chemistry; Catalysis. Modeling the structure of nascent discoidal high
density lipoprotein particles using experimental hydro-
gen deuterium exchange and neutron scattering data.
Study the mechanism of arginine oxidation by Nitric Oxide Synthase by using QM/MM calculations. Study the
oxygen inhibition and reactivation of Hydrogenase using
QM/MM calculations. Developing new computational
tools for computational chemistry: QM/MM method; hydrogen deuterium exchange; neutron scattering. TEL:
(216) 875-9717 FAX: (216) 687-9298
Email: [email protected]
Abdessamad Ababou, Arjan van der Vaart, Valentin Gogonea and Kenneth M. Merz, Interaction energy decomposition
in protein-protein association: A quantum mechanical study
of barnase-barstar complex, Biophys. Chem, 125, 221-236
(2007).
Stefan Motiu, Daniela Dogaru and Valentin Gogonea,
Reactivation pathway of the hydrogenase H-cluster: density
functional theory study, Int. J. Quantum Chem, 107, 12481252 (2007).
Zhiping Wu, Matthew A. Wagner, Lemin Zheng, John S.
Parks, Jacinto M Shy, III, Jonathan D. Smith, Valentin Gogonea and Stanley L. Hazen, The refined structure of nascent
HDL reveals a key functional domain for particle maturation
and dysfunction, Nat. Struct. Mol. Biol, 14, 861-868 (2007).
P. K. Biswas and Valentin Gogonea, A polarizable forcefield model for quantum-mechanical-molecular-mechanical
Hamiltonian using expansion of point charges into orbitals, J.
Chem. Phys, 129, 154108/1-154108/13 (2008).
Zhiping Wu, Matthew A. Wagner, Lemin Zheng, John S.
Parks, Jacinto M. Shy, Jonathan D. Smith, Valentin Gogonea
and Stanley L. Hazen, The refined structure of nascent HDL
reveals a key functional domain for particle maturation and
dysfunction. [Erratum to document cited in CA147:442177],
Nat. Struct. Mol. Biol, 15, 330 (2008).
Zhiping Wu, Matthew A. Wagner, Lemin Zheng, John S.
Parks, Jacinto M. Shy, Jonathan D. Smith, Valentin Gogonea
and Stanley L. Hazen, The refined structure of nascent HDL
reveals a key functional domain for particle maturation and
dysfunction. [Erratum to document cited in CA147:442177],
Nat. Struct. Mol. Biol, 15, 651 (2008).
V. Gogonea, An approach to solvent effect modeling by
the combined scaled-particle theory and dielectric continuum-medium method. (D)
GUO, BAOCHUAN (b.1961) Professor. B.S, 1982,
Zhengzhou University; M.S, 1985, Chinese Academy of
Science; Ph.D, 1992, Pennsylvania State University.
Postdoctoral Research Associate, 1992-1994, Pennsylvania State University. Bioanalytical Chemistry. MALDITOF and ESI mass spectrometry; development of new
mass spectrometric techniques for the rapid identification
and structural characterization of macromolecules; largescale genotyping of SNPs; early detection of cancers
with DNA-based technologies; mass spectrometric proteomics; mass spectrometric analysis polymers. TEL:
(216) 687-2471 FAX: (216) 687-9298
Email: [email protected]
No publication information submitted for this edition.
GUPTA, MANJULA K. (b.1942) Clinical Professor.
B.S, 1959, Agra University (India); M.S, 1961, Agra
University (India); Ph.D, 1966, Agra University (India).
Post Doctoral Fellow, 1970-1972, Cleveland Clinic
Found; Research Associate, 1972-1973, Cleveland Clinic
Found. Clinical Chemistry; Immunology. Focus of research is in defining the role of: Cancer Biomarkers; by
use of sensitive molecular techniques like reverse transcriptase polymerase chain reaction(RT-PCR) in the detection/screening/staging of various endocrine cancers
including prostate, breast and thyroid cancers. Autoantibodies; using cloned genes and in vitro transcription and
translation of cloned auto-antigen genes in autoimmune
endocrinopathies. TEL: (216) 444-2714 FAX: (216) 4459444
Email: [email protected]
K. Wagner, R. Arciaga, A. Siperstein, M. Milas, I. Warshawsky, S. S. K. Reddy and M. K. Gupta, Thyrotropin Receptor/thyroglobulin mRNA in peripheral blood and fine needle aspiration cytology: Diagnostic synergy for detecting thyroid cancer, J of Clin Endocrinol Metab, 90, 1921-1924
(2005).
D. J. Brotman, J. P. Girod, M. J. Garcia, J. V. Patel, M.
Gupta, A. Posch, S. Saunders, G. Y. H. Lip, S. Worlet and S.
Reddy, Effects of short –term glucocorticoids on cardiovascular biomarkers, J of Clin Endocrinol Metab, 90, 3202-3208
(2005).
D. J. Brotman, J. P. Girod, A. Posch, J. T. Jani, J. V. Patel,
M. Gupta, G. Y. H. Lip, S. Reddy and T. S. Kickler, Effects
of short-term glucocorticoids on Hemostatic factors in
healthy volunteers, Thrombosis Research, 118, 247-252
(2006).
Su-Ynn Chia, Mira Milas, Sethu K. Reddy, Allan Siperstein, Mario Skugor, Jennifer Brainard and Manjula K. Gupta, Thyroid-stimulating hormone receptor messenger ribonucleic acid measurement in blood as a marker for circulating
thyroid cancer cells and its role in the preoperative diagnosis
of thyroid cancer, J. Clin. Endocrinol. Metab, 92, 468-475
(2007).
3
M. Milas, P. Mazzaglia, S. Chia, M. Skugor, E. Burber, S.
Reddy, M. Gupta and A. Siperstien, The utility of peripheral
thyrotropin receptor mRNA in the diagnosis of follicular neoplasms and surveillance of thyroid cancers, Surgery, 141,
137-146 (2007).
HAQUE, JAHARUL S. CCF Assistant Professor.
B.Sc, 1974, University of Calcutta, India; M.Sc, 1976,
University of Calcutta, India; Ph.D, 1985, University of
Calcutta, India. TEL: (216) 445-6622 FAX: (216) 4456269
Email: [email protected]
No publication information submitted for this edition.
HAZEN, STANLEY L. (b.1963) CCF Professor. B.A,
1981, Washington University; M.D, 1992, Washington
University; Ph.D, 1992, Washington University. Fellowship in Endocrinology, 1994-1996, Washington University; Howard Hughes Postdoctoral Fellow, 1994-1997,
Washington University. Cell Biology. Oxidation chemistry; inflammation biochemistry, mechanisms of free radical damage of biological matrices; research uses high
performance liquid chromatography; gas chromatography-mass spectrometry; electrospray ionization tandem
mass spectrometry; spectroscopy; rapid kinetics; mouse
models of diseases; development of novel diagnostic
markers; human clinical studies. TEL: (216) 445-9763
FAX: (216) 444-9404
Web: www.lerner.ccf.org/pi/hazens.html
Email: [email protected]
Publication list has not been verified by the department.
Deepak L. Bhatt, Derek P. Chew, Cindy Grines, Debabrata
Mukherjee, Massoud Leesar, Ian C. Gilchrist, John C. Corbelli, James C. Blankenship, Avichai Eres, Steven Steinhubl,
Walter A. Tan, Jon R. Resar, Amjad AlMahameed, Ahmed
Abdel-Latif, H. Wilson Tang, Danielle Brennan, Ellen McErlean, Stanley L. Hazen and Eric J. Topol, Peroxisome proliferator-activated receptor ␥ agonists for the Prevention of
Adverse events following percutaneous coronary Revascularization—results of the PPAR Study, Am. Heart J, 154, 137143 (2007).
Gong-Qing Shen, Lin Li, Domenico Girelli, Sara B. Seidelmann, Shaoqi Rao, Chun Fan, Jeong Euy Park, Quansheng Xi, Jing Li, Ying Hu, Oliviero Olivieri, Kandice Marchant, John Barnard, Roberto Corrocher, Robert Elston, June
Cassano, Susan Henderson, Stanley L. Hazen, Edward F.
Plow, Eric J. Topol and Qing K. Wang, An LRP8 variant is
associated with familial and premature coronary artery disease and myocardial infarction, Am. J. Hum. Genet, 81, 780791 (2007).
Leonor Thomson, Jason Christie, Caryn Vadseth, Paul N.
Lanken, Xiaoming Fu, Stanley L. Hazen and Harry Ischiropoulos, Identification of immunoglobulins that recognize 3nitrotyrosine in patients with acute lung injury after major
trauma, Am. J. Respir. Cell Mol. Biol, 36, 152-157 (2007).
Jenny C. Lee, Daphna Weissglas-Volkov, Mira Kyttaelae,
Janet S. Sinsheimer, Anne Jokiaho, Tjerk W. A. de Bruin,
Aldons J. Lusis, Marie-Luise Brennan, Marleen M. J. van
Greevenbroek, Carla J. H. van der Kallen, Stanley L. Hazen
and Paeivi Pajukanta, USF1 contributes to high serum lipid
Levels in Dutch FCHL families and USA Whites with coronary artery disease, Arterioscler., Thromb., Vasc. Biol, 27,
2222-2227 (2007).
Xin-Min Li, Robert G. Salomon, Jun Qin and Stanley L.
Hazen, Conformation of an Endogenous Ligand in a Membrane Bilayer for the Macrophage Scavenger Receptor
CD36, Biochemistry, 46, 5009-5017 (2007).
Ioannis Parastatidis, Leonor Thomson, Diana M. Fries,
Ryan E. Moore, Junichiro Tohyama, Xiaoming Fu, Stanley
L. Hazen, Harry F. G. Heijnen, Michelle K. Dennehy, Daniel
C. Liebler, Daniel J. Rader and Harry Ischiropoulos, Increased protein nitration burden in the atherosclerotic lesions
and plasma of apolipoprotein A-I-deficient mice, Circ. Res,
101, 368-376 (2007).
Stephen J. Nicholls, Zeneng Wang, Robert Koeth, Bruce
Levison, Brian DelFraino, Vladimir Dzavik, Owen W. Griffith, David Hathaway, Julio A. Panza, Steven E. Nissen, Judith S. Hochman and Stanley L. Hazen, Metabolic Profiling
of Arginine and Nitric Oxide Pathways Predicts Hemodynamic Abnormalities and Mortality in Patients With Cardiogenic Shock After Acute Myocardial Infarction, Circulation,
116, 2315-2324 (2007).
Vladimir Dzavik, Gad Cotter, Harmony R. Reynolds, John
H. Alexander, Krishnan Ramanathan, Amanda L. Stebbins,
David Hathaway, Michael E. Farkouh, E. Magnus Ohman,
David A. Baran, Roland Prondzinsky, Julio A. Panza, Warren J. Cantor, Zvi Vered, Christopher E. Buller, Neal S. Kleiman, John G. Webb, David R. Holmes, Joseph E. Parrillo,
Stanley L. Hazen, Steven S. Gross, Robert A. Harrington and
Judith S. Hochman, Effect of nitric oxide synthase inhibition
on hemodynamics and outcome of patients with persistent
cardiogenic shock complicating acute myocardial infarction:
a phase II dose-ranging study, Eur. Heart J, 28, 1109-1116
(2007).
Tzung K. Hsiai, Juliana Hwang, Mark L. Barr, Adria Correa, Ryan Hamilton, Mohammad Alavi, Mahsa Rouhanizadeh, Enrique Cadenas and Stanley L. Hazen, Hemodynamics
influences vascular peroxynitrite formation: Implication for
4
CLEVELAND STATE
low-density lipoprotein apo-B-100 nitration, Free Radical
Biol. Med, 42, 519-529 (2007).
Steven B. Cannady, Pete S. Batra, Rachel Leahy, Martin J.
Citardi, Allison Janocha, Kristin Ricci, Suzy A. A. Comhair,
Melanie Bodine, Zeneng Wang, Stanley L. Hazen and Serpil
C. Erzurum, Signal transduction and oxidative processes in
sinonasal polyposis, J. Allergy Clin. Immunol, 120, 13461353 (2007).
Marijn C. Meuwese, Erik S. G. Stroes, Stanley L. Hazen,
Joram N. van Miert, Jan Albert Kuivenhoven, Robert G.
Schaub, Nicholas J. Wareham, Robert Luben, John J. P. Kastelein, Kay-Tee Khaw and S. Matthijs Boekholdt, Serum Myeloperoxidase Levels Are Associated With the Future Risk of
Coronary Artery Disease in Apparently Healthy Individuals:
The EPIC-Norfolk Prospective Population Study, J. Am.
Coll. Cardiol, 50, 159-165 (2007).
W. H. Wilson Tang, Wilson Tong, Richard W. Troughton,
Maureen G. Martin, Kevin Shrestha, Allen Borowski, Sue
Jasper, Stanley L. Hazen and Allan L. Klein, Prognostic Value and Echocardiographic Determinants of Plasma Myeloperoxidase Levels in Chronic Heart Failure, J. Am. Coll. Cardiol, 49, 2364-2370 (2007).
Shany Blum, Roy Asaf, Julia Guetta, Rachel Miller-Lotan,
Rabea Asleh, Ran Kremer, Nina S. Levy, Franklin G. Berger,
Doron Aronson, Xiaoming Fu, Renliang Zhang, Stanley L.
Hazen and Andrew P. Levy, Haptoglobin Genotype Determines Myocardial Infarct Size in Diabetic Mice, J. Am. Coll.
Cardiol, 49, 82-87 (2007).
Stephen J. Nicholls, E. Murat Tuzcu, Ilke Sipahi, Adam W.
Grasso, Paul Schoenhagen, Tingfei Hu, Kathy Wolski, Tim
Crowe, Milind Y. Desai, Stanley L. Hazen, Samir R. Kapadia
and Teven E. Nissen, Statins, high-density lipoprotein cholesterol, and regression of coronary atherosclerosis, JAMA, J.
Am. Med. Assoc, 297, 499-508 (2007).
Eugene A. Podrez, Tatiana V. Byzova, Maria Febbraio,
Robert G. Salomon, Yi Ma, Manojkumar Valiyaveettil, Eugenia Poliakov, Mingjiang Sun, Paula J. Finton, Brian R.
Curtis, Juhua Chen, Renliang Zhang, Roy L. Silverstein and
Stanley L. Hazen, Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype, Nat. Med. (N. Y.,
NY, U. S.), 13, 1086-1095 (2007).
Zeneng Wang, Stephen J. Nicholls, E. Rene Rodriguez,
Outi Kummu, Sohvi Hoerkkoe, John Barnard, Wanda F.
Reynolds, Eric J. Topol, Joseph A. DiDonato and Stanley L.
Hazen, Protein carbamylation links inflammation, smoking,
uremia and atherogenesis, Nat. Med. (N. Y., NY, U. S.), 13,
1176-1184 (2007).
Zhiping Wu, Matthew A. Wagner, Lemin Zheng, John S.
Parks, Jacinto M Shy, III, Jonathan D. Smith, Valentin Gogonea and Stanley L. Hazen, The refined structure of nascent
HDL reveals a key functional domain for particle maturation
and dysfunction, Nat. Struct. Mol. Biol, 14, 861-868 (2007).
Viktor Brovkovych, Xiao-Pei Gao, Evan Ong, Svitlana
Brovkovych, Marie-Luise Brennan, Xiao Su, Stanley L. Hazen, Asrar B. Malik and Randal A. Skidgel, Augmented inducible nitric oxide synthase expression and increased NO
production reduce sepsis-induced lung injury and mortality in
myeloperoxidase-null mice, Am. J. Physiol, 295, L96-L103
(2008).
Ephraim Sehayek and Stanley L. Hazen, Cholesterol absorption from the intestine is a major determinant of reverse
cholesterol transport from peripheral tissue macrophages, Arterioscler., Thromb., Vasc. Biol, 28, 1296-1297 (2008).
Dao-Quan Peng, Gregory Brubaker, Zhiping Wu, Lemin
Zheng, Belinda Willard, Michael Kinter, Stanley L. Hazen
and Jonathan D. Smith, Apolipoprotein A-I Tryptophan Substitution Leads to Resistance to Myeloperoxidase-Mediated
Loss of Function, Arterioscler., Thromb., Vasc. Biol, 28,
2063-2070 (2008).
Adriana G. Ioachimescu, Danielle M. Brennan, Brian M.
Hoar, Stanley L. Hazen and Byron J. Hoogwerf, Serum uric
acid is an independent predictor of all-cause mortality in patients at high risk of cardiovascular disease a preventive cardiology information system (PreCIS) database cohort study,
Arthritis Rheum, 58, 623-630 (2008).
Jean-Claude Tardif, Jean Gregoire, Philippe L. L’Allier,
Reda Ibrahim, Todd J. Anderson, Francois Reeves, Lawrence
M. Title, Erick Schampaert, Michel LeMay, Jacques Lesperance, Rob Scott, Marie-Claude Guertin, Marie-Luise Brennan, Stanley L. Hazen and Olivier F. Bertrand, Effects of the
antioxidant succinobucol (AGI-1067) on human atherosclerosis in a randomized clinical trial, Atherosclerosis (Amsterdam, Neth.), 197, 480-486 (2008).
David A. Morrow, Marc S. Sabatine, Marie-Luise Brennan, James A. de Lemos, Sabina A. Murphy, Christian T.
Ruff, Nader Rifai, Christopher P. Cannon and Stanley L.
Hazen, Concurrent evaluation of novel cardiac biomarkers in
acute coronary syndrome: myeloperoxidase and soluble
CD40 ligand and the risk of recurrent ischaemic events in
TACTICS-TIMI 18, Eur. Heart J, 29, 1096-1102 (2008).
Stanley L. Hazen, Oxidized Phospholipids as Endogenous
Pattern Recognition Ligands in Innate Immunity, J. Biol.
Chem, 283, 15527-15531 (2008).
Michael E. Greenberg, Xin-Min Li, Bogdan G. Gugiu,
Xiaodong Gu, Jun Qin, Robert G. Salomon and Stanley L.
Hazen, The Lipid Whisker Model of the Structure of Oxidized Cell Membranes, J. Biol. Chem, 283, 2385-2396
(2008).
Guangxu Jin, Xiaobo Zhou, Honghui Wang, Hong Zhao,
Kemi Cui, Xiang-Sun Zhang, Luonan Chen, Stanley L. Hazen, King Li and Stephen T. C. Wong, The Knowledge-Inte-
grated Network Biomarkers Discovery for Major Adverse
Cardiac Events, J. Proteome Res, 7, 4013-4021 (2008).
Tamali Bhattacharyya, Stephen J. Nicholls, Eric J. Topol,
Renliang Zhang, Xia Yang, David Schmitt, Xiaoming Fu,
Mingyuan Shao, Danielle M. Brennan, Stephen G. Ellis,
Marie-Luise Brennan, Hooman Allayee, Aldons J. Lusis and
Stanley L. Hazen, Relationship of paraoxonase 1 (PON1)
gene polymorphisms and functional activity with systemic
oxidative stress and cardiovascular risk, JAMA, J. Am. Med.
Assoc, 299, 1265-1276 (2008).
Zhiping Wu, Matthew A. Wagner, Lemin Zheng, John S.
Parks, Jacinto M. Shy, Jonathan D. Smith, Valentin Gogonea
and Stanley L. Hazen, The refined structure of nascent HDL
reveals a key functional domain for particle maturation and
dysfunction. [Erratum to document cited in CA147:442177],
Nat. Struct. Mol. Biol, 15, 330 (2008).
Zhiping Wu, Matthew A. Wagner, Lemin Zheng, John S.
Parks, Jacinto M. Shy, Jonathan D. Smith, Valentin Gogonea
and Stanley L. Hazen, The refined structure of nascent HDL
reveals a key functional domain for particle maturation and
dysfunction. [Erratum to document cited in CA147:442177],
Nat. Struct. Mol. Biol, 15, 651 (2008).
IP, MICHAEL PO CHEE (b.1946) Clinical Professor. B.S, 1970, McGill University; M.Sc, 1972, McMaster University; Ph.D, 1976, University of Windsor. Clinical Laboratory Director Trainee, 1980-1985, Mount Sinai Medical Center, New York, NY; DABCC, 1989,
American Board of Clinical Chemistry. Clinical Chemistry. Serum myeloperoxidase for evaluation of non ST
myocardial infarctions patients due to ruptured plaques
versus those due to generalized stress without ruptured
plaques. TEL: (216) 778-5183 FAX: (216) 778-5701
Email: [email protected]
No publication information submitted for this edition.
JACOBSEN, DONALD W. (b.1939) CCF Professor.
B.A, 1961, University of Pennsylvania; M.S, 1965, Oregon State University; Ph.D, 1967, Oregon State University. Postdoctoral Fellow, 1967-1972, Scripps Clinic and
Res. Foundation. Biochemistry; Cell Biology. Biochemistry and metabolism of homocysteine, cobalamin and folic acid; role of homocysteine in atherogenesis; treatment
of hyperhomocysteinemia. TEL: (216) 444-8340 FAX:
(216) 444-9404
Web: www.lerner.ccf.org/cellbio/jacobsen/
Email: [email protected]
Publication list has not been verified by the department.
Luciana Hannbial, Clyde A. Smith, Donald W. Jacobsen
and Nicola E. Brasch, Nitroxylcob(III)alamin: synthesis and
X-ray structural characterization, Angew. Chem., Int. Ed, 46,
5140-5143 (2007).
Alla V. Glushchenko and Donald W. Jacobsen, Molecular
targeting of proteins by L-homocysteine: mechanistic implications for vascular disease, Antioxid. Redox Signaling, 9,
1883-1898 (2007).
Luciana Hannibal, Scott D. Bunge, Rudi van Eldik, Donald
W. Jacobsen, Christoph Kratky, Karl Gruber and Nicola E.
Brasch, X-ray Structural Characterization of Imidazolylcobalamin and Histidinylcobalamin: Cobalamin Models for
Aquacobalamin Bound to the B12 Transporter Protein Transcobalamin, Inorg. Chem. (Washington, DC, U. S.), 46,
3613-3618 (2007).
Luciana Hannibal, Armend Axhemi, Alla V. Glushchenko,
Edward S. Moreira, Nicola E. Brasch and Donald W. Jacobsen, Accurate assessment and identification of naturally occurring cellular cobalamins, Clinical Chemistry and Laboratory Medicine, 46, 1739-1746 (2008).
Ji Zhou, Geoff H. Werstuck, Sarka Lhotak, Yuan Y. Shi,
Vivienne Tedesco, Bernardo Trigatti, Jeffrey Dickhout, Alana K. Majors, Patricia M. Di Bello, Donald W. Jacobsen and
Richard C. Austin, Hyperhomocysteinemia induced by methionine supplementation does not independently cause atherosclerosis in C57BL/6J mice, FASEB J, 22, 2569-2578
(2008).
KALAFATIS, MICHAEL (b.1958) Professor. B.S,
1983, University of Paris; M.S, 1984, University of
Paris; Ph.D, 1989, University of Paris. Postdoctoral Associate, 1989-1993, University of Vermont; Postdoctoral
Fellow,
1993-1994,
University
of
Vermont.
Biochemistry; Molecular Biology. Biochemistry of blood
coagulation and thrombosis; regulation of the assembly
of the prothrombinase complex; regulation of blood clotting and thrombosis at the surface of platelets and endothelial cells; phosphorylation of blood clotting proteins
by platelet kinases and significance of phosphorylation;
signal transduction. TEL: (216) 687-2460 FAX: (216)
687-9298
Web: www.csuohio.edu/chemistry/kalafatis.htm
Email: [email protected]
and Michael Kalafatis, Cooperative Regulation of the Activity of Factor Xa within Prothrombinase by Discrete Amino
Acid Regions from Factor Va Heavy Chain, Biochemistry,
47, 12835-12843 (2008).
Melissa A. Barhoover, Tivadar Orban, Daniel O. Beck,
Michael A. Bukys and Michael Kalafatis, Contribution of
Amino Acid Region 334-335 from Factor Va Heavy Chain to
the Catalytic Efficiency of Prothrombinase, Biochemistry, 47,
6840-6850 (2008).
Jamila Hirbawi, Michael A. Bukys, Melissa A. Barhoover,
Evrim Erdogan and Michael Kalafatis, Role of the Acidic Hirudin-like COOH-Terminal Amino Acid Region of Factor Va
Heavy Chain in the Enhanced Function of Prothrombinase,
Biochemistry, 47, 7963-7974 (2008).
Michael A. Bukys, Tivadar Orban, Paul Y. Kim, Michael
E. Nesheim and Michael Kalafatis, The interaction of fragment I of prothrombin with the membrane surface is a prerequisite for optimum expression of factor Va cofactor activity within prothrombinase, Thromb. Haemostasis, 99, 511522 (2008).
KARNIK, SADASHIVA (b.1954) CCF Professor.
B.Sc, 1973, University of Mysore, India; M.Sc, 1976,
Kasturba Medical College, Manipal, India; Ph.D, 1982,
Indian Institute of Science, Bangalore, India. Postdoctoral Fellow, 1982-1984, Institut fur Molekular Biololgie I,
University of Zurich, Zurich, Switzerland; Research Associate, 1984-1990, Massachusetts Institute of Technology, Cambridge, Massachusetts. Biotechnology; Molecular Biology. GPCR structure-function, signaling and
pathophysiology molecular modeling, pharmacology,
drug development, proteomics and genomics. TEL: (216)
444-1269 FAX: (216) 444-9263
Web: lerner.ccf.org/moleccard/karnik/
Email: [email protected]
No publication information submitted for this edition.
KINTER, MICHAEL CCF Associate Professor. B.S,
1982, James Madison University; Ph.D, 1986, University
of North Carolina, Chapel Hill. Research Assistant Professor, 1986-1988, University of Virginia. Analytical
Chemistry; Bioanalytical Chemistry. I am interested in
the development and application of qualitative and quantitative analysis using mass spectrometry in biomedical
research. I am also interested in the chemistry and
biochemistry of biological oxidation reactions including
the role of these reactions in human disease. This interest
includes studies of the factors that control biological oxidation reactions and development of new analytical
methods for studying the chemistry and toxicology of
these reactions. TEL: (216) 444-7170 FAX: (216) 4449404
Web: www.lerner.ccf.org/cellbio/kinter/
Email: [email protected]
Publication list has not been verified by the department.
Ming Jing, Joanna Bohl, Nicole Brimer, Michael Kinter
and Scott B. Vande Pol, Degradation of tyrosine phosphatase
PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteins, J. Virol, 81, 2231-2239 (2007).
Suparna Mazumder, Dragos Plesca, Michael Kinter and
Alexandru Almasan, Interaction of a cyclin E fragment with
Ku70 regulates Bax-mediated apoptosis, Mol. Cell. Biol, 27,
3511-3520 (2007).
Dao-Quan Peng, Gregory Brubaker, Zhiping Wu, Lemin
Zheng, Belinda Willard, Michael Kinter, Stanley L. Hazen
and Jonathan D. Smith, Apolipoprotein A-I Tryptophan Substitution Leads to Resistance to Myeloperoxidase-Mediated
Loss of Function, Arterioscler., Thromb., Vasc. Biol, 28,
2063-2070 (2008).
Yubin He, Diane J. Greene, Michael Kinter and Richard E.
Morton, Control of cholesteryl ester transfer protein activity
by sequestration of lipid transfer inhibitor protein in an inactive complex, J. Lipid Res, 49, 1529-1537 (2008).
Junnan Chen, Michael Kinter, Samuel Shank, Calvin Cotton, Thomas J. Kelley and Assem G. Ziady, Dysfunction of
Nrf-2 in CF epithelia leads to excess intracellular H2O2 and
inflammatory cytokine production, PLoS One, 3, No pp. given (2008).
LARNER, ANDREW C. (b.1953) CCF Professor.
B.A, 1975, Haverford College; M.D., Ph.D, 1982, University of Virginia. Post doctoral Fellow, 1982-1985,
Rockefeller University; Resident, Pathology, 1985-1988,
NCI. I am interested in the intracellular signaling cascades that control interferon regulated gene expression,
and relating these cascades to the biological actions of
these cytokines. TEL: (216) 445-9045 FAX: (216) 4448321
Email: [email protected]
No publication information submitted for this edition.
Publication list has not been verified by the department.
Evrim Erdogan, Michael A. Bukys, Thomas Orfeo, Kenneth G. Mann and Michael Kalafatis, Identification of an inactivating cleavage site for ␣-thrombin on the heavy chain of
factor Va, Thromb. Haemostasis, 98, 998-1006 (2007).
Melissa A. Barhoover, Tivadar Orban, Michael A. Bukys
LI, XIAOXIA CCF Assistant Professor. B.S, 1983,
Wuhan University, China; Ph.D, 1990, University of
Texas M.D. Anderson Cancer Center. Research Associate, 1990-1993, University of Texas M.D. Anderson
Cancer Center; Research Associate, 1994-1997, Cleve-
CLEVELAND STATE
land Clinic Foundation. TEL: (216) 445-8706 FAX:
(216) 444-9329
Email: [email protected]
Publication list has not been verified by the department.
Baoli Wang, Fang Zheng, Jinxing Quan, Xiaoxia Li, Yubing Liu, Bei Sun, Rui Zhang, Gang Guo and Jingyu Zhang, A
PCR-based technique to construct T-vectors for highthroughput cloning of PCR products, Anal. Biochem, 363,
303-305 (2007).
Baoli Wang, Hui Liang, Rui Liu, Xiaoxia Li, Bei Sun, Rui
Zhang, Shanyi Guo, Gang Guo, Jingyu Zhang and Chenlin
Dai, Construction of a restriction-endonuclease-Eam1105Igenerated T-vector for high-throughput cloning and expression, Biotechnol. Appl. Biochem, 48, 29-33 (2007).
Baoli Wang, Xiaoxia Li, Fang Zheng, Rui Liu, Jinxing
Quan, Hui Liang, Shanyi Guo, Gang Guo and Jingyu Zhang,
pEGFP-T, a novel T-vector for the direct, unidirectional
cloning and analysis of PCR-amplified promoters, Biotechnol. Lett, 29, 309-312 (2007).
Jianbo Guo, Jiti Zhou, Dong Wang, Cunping Tian, Ping
Wang and Xiaoxia Li, Isolation, identification and the growing condition of a dye-decolorization and salt-tolerant bacteria strain GTY, Huanjing Kexue Xuebao, 27, 201-205 (2007).
Honglan Qi, Yan Li, Xiaoxia Li and Chengxiao Zhang,
Current development of aptamer-based sensors, Huaxue
Chuanganqi, 27, 1-8 (2007).
Yuxiang Guo and Xiaoxia Li, Study of thermal decomposition of cesium nitrate, Huogongpin, 24-27 (2007).
Hui Xiao, Muhammet Fatih Gulen, Jinzhong Qin, Jianhong
Yao, Katarzyna Bulek, Danielle Kish, Cengiz Zubeyir Altuntas, David Wald, Caixia Ma, Hang Zhou, Vincent K. Tuohy,
Robert L. Fairchild, Carol de la Motte, Daniel Cua, Bruce A.
Vallance and Xiaoxia Li, The toll-interleukin-1 receptor
member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis, Immunity, 26, 461-475
(2007).
Jianhong Yao, Tae Whan Kim, Jinzhong Qin, Zhengfan
Jiang, Youcun Qian, Hui Xiao, Yi Lu, Wen Qian, Muhammet Fatih Gulen, Nywana Sizemore, Joseph DiDonato, Shintaro Sato, Shizuo Akira, Bing Su and Xiaoxia Li, Interleukin1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NF␬B Activation Pathways Bifurcate at IL-1 Receptorassociated Kinase Modification, J. Biol. Chem, 282, 60756089 (2007).
Xiaoxia Li, Weiyang Li, Hua Ma and Jun Chen, Electrochemical Lithium Intercalation/Deintercalation of SingleCrystalline V2O5 Nanowires, J. Electrochem. Soc, 154, A39A42 (2007).
Tae Whan Kim, Kirk Staschke, Katarzyna Bulek, Jianhong
Yao, Kristi Peters, Keun-Hee Oh, Yvonne Vandenburg, Hui
Xiao, Wen Qian, Tom Hamilton, Booki Min, Ganes Sen,
Raymond Gilmour and Xiaoxia Li, A critical role for IRAK4
kinase activity in Toll-like receptor-mediated innate immunity, J. Exp. Med, 204, 1025-1036 (2007).
Cheng-Lung Ku, Horst von Bernuth, Capucine Picard,
Shen-Ying Zhang, Huey-Hsuan Chang, Kun Yang, Maya
Chrabieh, Andrew C. Issekutz, Coleen K. Cunningham, John
Gallin, Steven M. Holland, Chaim Roifman, Stephan Ehl,
Joanne Smart, Mimi Tang, Franck J. Barrat, Ofer Levy,
Douglas McDonald, Noorbibi K. Day-Good, Richard Miller,
Hidetoshi Takada, Toshiro Hara, Sami Al-Hajjar, Abdulaziz
Al-Ghonaium, David Speert, Damien Sanlaville, Xiaoxia Li,
Frederic Geissmann, Eric Vivier, Laszlo Marodi, Ben-Zion
Garty, Helen Chapel, Carlos Rodriguez-Gallego, Xavier Bossuyt, Laurent Abel, Anne Puel and Jean-Laurent Casanova,
Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity, J. Exp. Med, 204, 24072422 (2007).
Justin Hartupee, Caini Liu, Michael Novotny, Xiaoxia Li
and Thomas Hamilton, IL-17 Enhances Chemokine Gene
Expression through mRNA Stabilization, J. Immunol, 179,
4135-4141 (2007).
Thomas A. Hamilton, Michael Novotny, Shyamasree Datta, Palash Mandal, Justin Hartupee, Julie Tebo and Xiaoxia
Li, Chemokine and chemoattractant receptor expression:
post-transcriptional regulation, J. Leukocyte Biol, 82, 213219 (2007).
Xiaoxia Li and Yuhua Wang, Synthesis of Gd1xTbxAl3(BO3)4 (0.05ⱕxⱕ1) and its luminescence properties
under VUV excitation, J. Lumin, 122, 1000-1002 (2007).
Huanqiao Song, Xinping Qiu, Xiaoxia Li, Fushen Li, Wentao Zhu and Liquan Chen, TiO2 nanotubes promoting Pt/C
catalysts for ethanol electro-oxidation in acidic media, J.
Power Sources, 170, 50-54 (2007).
Xiaoxia Li, Xiaolong Yuan, Fengguang Nie and Guo Li,
Overview of ChIN, a Web guide of chemical information for
10 years, Jisuanji Yu Yingyong Huaxue, 24, 125-129 (2007).
Xiaoxia Li and Chungen Zhou, Development and oxidation resistance of Si-modified MCrAlY coatings on Nb-base
alloy, Mater. Sci. Forum, 546, 1721-1724 (2007).
Youcun Qian, Caini Liu, Justin Hartupee, Cengiz Zubeyir
Altuntas, Muhammet Fatih Gulen, Daniel Jane-wit, Jianhua
Xiao, Yi Lu, Natalia Giltiay, Jinbo Liu, Tomasz Kordula, QiWei Zhang, Bruce Vallance, Shadi Swaidani, Mark Aronica,
Vincent K. Tuohy, Thomas Hamilton and Xiaoxia Li, The
adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease,
Nat. Immunol, 8, 247-256 (2007).
Honglan Qi, Xiaoxia Li, Pei Chen and Chengxiao Zhang,
Electrochemical detection of DNA hybridization based on
polypyrrole/ss-DNA/multi-wall carbon nanotubes paste electrode, Talanta, 72, 1030-1035 (2007).
Bo Li, Xiaoxia Li, Tianmin Wang and Feng Cheng, Studies on blood compatibility and corrosion resistance of TiN
films on NiTi alloys, Xiyou Jinshu Cailiao Yu Gongcheng,
36, 857-861 (2007).
Xiaoxia Li, Yingying Han, Wei Pang, Chenghong Li, Xuefen Xie, John Y.-J. Shyy and Yi Zhu, AMP-Activated Protein
Kinase Promotes the Differentiation of Endothelial Progenitor Cells, Arterioscler., Thromb., Vasc. Biol, 28, 1789-1795
(2008).
Jinquan Cheng, Jianping Liu, Xiaoxia Li, Lei Yu, Ji Peng,
Renli Zhang, Yijie Geng and Shaofa Nie, Effect of polymorphisms of endothelial nitric oxide synthase on ischemic
stroke: A case-control study in a Chinese population, Clin.
Chim. Acta, 392, 46-51 (2008).
Xiaoxia Li, Act1 modulates autoimmunity through its dual
functions in CD40L/BAFF and IL-17 signaling, Cytokine+,
41, 105-113 (2008).
Xiaoxia Li, Honglan Qi, Lihua Shen, Qiang Gao and
Chengxiao Zhang, Electrochemical aptasensor for the determination of cocaine incorporating gold nanoparticles modification, Electroanalysis, 20, 1475-1482 (2008).
Youcun Qian, Natalia Giltiay, Jianhua Xiao, Yue Wang,
Jun Tian, Shuhua Han, Martin Scott, Robert Carter, Trine N.
Jorgensen and Xiaoxia Li, Deficiency of Act1, a critical
modulator of B cell function, leads to development of Sjogren’s syndrome, Eur. J. Immunol, 38, 2219-2228 (2008).
Xiaoxia Li, IRAK4 in TLR/IL-1R signaling: possible clinical applications, Eur. J. Immunol, 38, 614-618 (2008).
Heshan Cai, Guoguang Liu and Xiaoxia Li, Photocatalytic
activity of Ho-doped TiO2 nanocrystallites under simulated
sunlight, Guisuanyan Xuebao, 36, 700-703 (2008).
Hui Xiao, Wen Qian, Kirk Staschke, Youcun Qian, Grace
Cui, Li Deng, Mariam Ehsani, Xiliang Wang, Yue-Wei Qian,
Zhijian J. Chen, Raymond Gilmour, Zhengfan Jiang and
Xiaoxia Li, Pellino 3b Negatively Regulates Interleukin-1-induced TAK1-dependent NF␬B Activation, J. Biol. Chem,
283, 14654-14664 (2008).
Justin Hartupee, Xiaoxia Li and Thomas Hamilton, Interleukin 1␣-induced NF␬B Activation and Chemokine mRNA
Stabilization Diverge at IRAK1, J. Biol. Chem, 283, 1568915693 (2008).
Jerzy Fraczek, Tae Whan Kim, Hui Xiao, Jianhong Yao,
Qian Wen, Yali Li, Jean-Laurent Casanova, Juliusz Pryjma
and Xiaoxia Li, The Kinase Activity of IL-1 Receptor-associated Kinase 4 Is Required for Interleukin-1 Receptor/Tolllike Receptor-induced TAK1-dependent NF␬B Activation, J.
Biol. Chem, 283, 31697-31705 (2008).
Angela C. Johnson, Xiaoxia Li and Eric Pearlman, MyD88
Functions as a Negative Regulator of TLR3/TRIF-induced
Corneal Inflammation by Inhibiting Activation of c-Jun Nterminal Kinase, J. Biol. Chem, 283, 3988-3996 (2008).
Feng Lan, Jinchong Xu, Xiaoyan Zhang, Vincent Wai-Sun
Wong, Xiaoxia Li, Aili Lu, Wenjing Lu, Li Shen and Lingsong Li, Hepatocyte growth factor promotes proliferation and
migration in immortalized progenitor cells, NeuroReport, 19,
765-769 (2008).
Horst von Bernuth, Capucine Picard, Zhongbo Jin, Rungnapa Pankla, Xiao Hui, Cheng-Lung Ku, Maya Chrabieh,
Imen Ben Mustapha, Pegah Ghandil, Yildiz Camcioglu, Julia
Vasconcelos, Nicolas Sirvent, Margarida Guedes, Artur Bonito Vitor, Maria Jose Herrero-Mata, Juan Ignacio Arostegui,
Carlos Rodrigo, Laia Alsina, Estibaliz Ruiz-Ortiz, Manel
Juan, Claudia Fortuny, Jordi Yaguee, Jordi Anton, Mariona
Pascal, Huey-Hsuan Chang, Lucile Janniere, Yoann Rose,
Ben-Zion Garty, Helen Chapel, Andrew Issekutz, Laszlo
Marodi, Carlos Rodriguez-Gallego, Jacques Banchereau,
Laurent Abel, Xiaoxia Li, Damien Chaussabel, Anne Puel
and Jean-Laurent Casanova, Pyogenic Bacterial Infections in
Humans with MyD88 Deficiency, Science (Washington, DC,
U. S.), 321, 691-696 (2008).
MASNOVI, JOHN (b.1954) Professor. B.S, 1975,
University of Notre Dame; M.S, 1977, University of Notre Dame; Ph.D, 1982, University of Chicago. 19821983, Indiana University; 1984-1985, University of
Houston. Photochemistry; Physical Organic Chemistry.
Electron transfer reactions, photochemistry, reactive intermediates, high energy compounds, eletron transport,
oxygen transport catalysts, preceramic polymers. TEL:
(216) 687-2469 FAX: (216) 687-9298
Web: www.csuohio.edu/chemistry/jm.html
Email: [email protected]
Publication list has not been verified by the department.
Mustafa Arslan, Erol Asker, John Masnovi and Ronald J.
Baker, 1,3-Bi-9-anthrylpropane, Acta Crystallogr., Sect. E:
Struct. Rep. Online, E63, o1800-o1801 (2007).
Mustafa Arslan, Erol Asker, John Masnovi and Ronald J.
Baker, 1,4-Di-9-anthrylbutane, Acta Crystallogr., Sect. E:
Struct. Rep. Online, E63, o2400-o2402 (2007).
Mustafa Arslan, John Masnovi and Randolph Krafcik,
Charge-transfer complex formation between p-chloranil and
1,n-dicarbazolylalkanes, Spectrochim. Acta, Part A, 66A,
1063-1067 (2007).
Erol Asker and John Masnovi, Structure of a 1:2 electron
donor-acceptor complex of 9,9’-diethyl-3,3’-di-9H-carbazolyl and tetracyanoethylene, Anal. Sci.: X-Ray Struct. Anal.
Online, 24, x105-x106 (2008).
5
MISONO, KUNIO CCF Associate Professor. Ph.D,
1978, Vanderbilt University. Research Associate, 19781980, Duke University. Cardiovascular regulation, receptor structure and signal transduction mechanism, structure and function of proteins and peptides, structural
biology, proteolytic enzymes and biological regulation,
enzyme catalytic mechanism and design of inhibitors,
bio-conjugate chemistry; protein chemistry; peptide
chemistry; combinatorial chemistry. TEL: (216) 4442054 FAX: (216) 444-9263
Email: [email protected]
Publication list has not been verified by the department.
Haruo Ogawa, Yue Qiu, Craig M. Ogata and Kunio Misono, X-ray crystal structure analysis of ANP receptors: application to drug discovery, Idenshi Igaku Mook, 8, 80-86, 1
Plate (2007).
MUNDELL, JOSEPH J. (b.1949) Adjunct Faculty.
B.S, 1980, University of Massachusetts; Ph.D, 1990,
Case Western Reserve University. Post-doctoral, 19901993, Case Western Reserve University; Visiting Scientist, 1993-1994, University of Toledo; Visiting Professor,
1994-1996, Case Western Reserve University; Visiting
Professor, 1996-1998, Kent State University. Chemistry
Education; Electrochemistry. TEL: (216) 523-7310
FAX: (216) 687-9298
Email: [email protected]
No publication information submitted for this edition.
NG, LILY M. Professor, Chair. B.A, 1978, Governors
State University; Ph.D, 1985, University of Pittsburgh.
Postdoctoral Research Associate, 1984-1986, University
of Pittsburgh; Research Assistant Professor, 1986-1987,
University of Pittsburgh. Bioanalytical Chemistry; Surface Chemistry. Mass-spectrometry of proteins. FTIR
spectroscopy of biomolecules. Vibrational spectroscopy
of surface species; catalytic, surface and tribology chemistry on metal clusters and oxides; liquid/solid surfaces
interactions. TEL: (216) 687-2467 FAX: (216) 687-9298
Web: www.csuohio.edu/chemistry
Email: [email protected]
No publication information submitted for this edition.
PADGETT, RICHARD A. (b.1953) CCF Associate
Professor. B.S, 1975, University of California, Irvine;
Ph.D, 1981, Stanford University. Postdoctoral Fellow,
1981-1985, Massachusetts Institute of Technology. Biochemistry; Molecular Biology. Molecular biology; RNA
processing; mechanism of RNA splicing; ribozyme reaction mechanisms. TEL: (216) 445-2692 FAX: (216) 4440512
Web: www.lerner.ccf.org/molecbio/padgett/
Email: [email protected]
Joan A. Steitz, Gideon Dreyfuss, Adrian R. Krainer, Angus
I. Lamond, A. Gregory Matera and Richard A. Padgett,
Where in the cell is the minor spliceosome?, Proc. Natl.
Acad. Sci. U. S. A, 105, 8485-8486 (2008).
Kwaku T. Dayie and Richard A. Padgett, A glimpse into
the active site of a group II intron and maybe the spliceosome, too, RNA, 14, 1697-1703 (2008).
Jay E. Brock, Rosemary D. Dietrich and Richard A. Padgett, Mutational analysis of the U12-dependent branch site
consensus sequence, RNA, 14, 2430-2439 (2008).
PLOW, EDWARD F. CCF Professor. Ph.D, 1970,
West Virginia University. Member and Head, Committee
for the Study of Vascular Biology, 1989-1992, The
Scripps Clinic and Research Foundation; Head of Research, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, 1992-, Cleveland Clinic Foundation;
Chairman, Department of Molecular Cardiology, 1994-,
Lerner Research Institute, Cleveland Clinic Foundation;
Vice-Chair, Lerner Research Institute, 1999-2002,
Cleveland Clinic Foundation. Cell adhesion receptors,
platelets, leukocytes, protein structure-function, plasminogen system, lipoprotein(a). TEL: (216) 445-8200
FAX: (216) 445-8204
Web: www.lerner.ccf.org/moleccard/plow/
Email: [email protected]
Publication list has not been verified by the department.
Gong-Qing Shen, Lin Li, Domenico Girelli, Sara B. Seidelmann, Shaoqi Rao, Chun Fan, Jeong Euy Park, Quansheng Xi, Jing Li, Ying Hu, Oliviero Olivieri, Kandice Marchant, John Barnard, Roberto Corrocher, Robert Elston, June
Cassano, Susan Henderson, Stanley L. Hazen, Edward F.
Plow, Eric J. Topol and Qing K. Wang, An LRP8 variant is
associated with familial and premature coronary artery disease and myocardial infarction, Am. J. Hum. Genet, 81, 780791 (2007).
Carmen M. Swaisgood, Mark A. Aronica, Shadi Swaidani
and Edward F. Plow, Plasminogen is an important regulator
in the pathogenesis of a murine model of asthma, Am. J. Respir. Crit. Care Med, 176, 333-342 (2007).
Olga I. Stenina, Eric J. Topol and Edward F. Plow,
Thrombospondins, their polymorphisms, and cardiovascular
6
CLEVELAND STATE
disease, Arterioscler., Thromb., Vasc. Biol, 27, 1886-1894
(2007).
Edward F. Plow and Elzbieta Pluskota, It’s not size, it’s
substance, Blood, 110, 2224-2225 (2007).
Riku Das, Tim Burke and Edward F. Plow, Histone H2B
as a functionally important plasminogen receptor on macrophages, Blood, 110, 3763-3772 (2007).
Ganapati H. Mahabeleshwar, Weiyi Feng, Kumar Reddy,
Edward F. Plow and Tatiana V. Byzova, Mechanisms of Integrin-Vascular Endothelial Growth Factor Receptor CrossActivation in Angiogenesis, Circ. Res, 101, 570-580 (2007).
Xiaohua Shi, Yan-Qing Ma, Yizeng Tu, Ka Chen, Shan
Wu, Koichi Fukuda, Jun Qin, Edward F. Plow and Chuanyue
Wu, The MIG-2/Integrin Interaction Strengthens Cell-Matrix
Adhesion and Modulates Cell Motility, J. Biol. Chem, 282,
20455-20466 (2007).
Dmitry A. Soloviev, William A. Fonzi, Rafael Sentandreu,
Elzbieta Pluskota, Christopher B. Forsyth, Satya Yadav and
Edward F. Plow, Identification of pH-Regulated Antigen 1
Released from Candida albicans as the Major Ligand for
Leukocyte Integrin ␣M␤2, J. Immunol, 178, 2038-2046
(2007).
Hai-Bo Wang, Jin-Tao Wang, Lei Zhang, Zhen H. Geng,
Wei-Li Xu, Tao Xu, Yuqing Huo, Xueliang Zhu, Edward F.
Plow, Ming Chen and Jian-Guo Geng, P-selectin primes leukocyte integrin activation during inflammation, Nat. Immunol, 8, 882-892 (2007).
Elzbieta Pluskota, Neil M. Woody, Dorota Szpak, Christie
M. Ballantyne, Dmitry A. Soloviev, Daniel I. Simon and Edward F. Plow, Expression, activation, and function of integrin ␣M␤2 (Mac-1) on neutrophil-derived microparticles,
Blood, 112, 2327-2335 (2008).
Hannu Larjava, Edward F. Plow and Chuanyue Wu, Kindlins: essential regulators of integrin signalling and cell-matrix
adhesion, EMBO Rep, 9, 1203-1208 (2008).
Yan-Qing Ma, Jun Qin, Chuanyue Wu and Edward F.
Plow, Kindlin-2 (Mig-2): a co-activator of ␤3 integrins, J.
Cell Biol, 181, 439-446 (2008).
Kumar B. Reddy, Dawn M. Smith and Edward F. Plow,
Analysis of Fyn function in hemostasis and ␣IIb␤3-integrin
signaling, J. Cell Sci, 121, 1641-1648 (2008).
Elzbieta Pluskota, Dmitry A. Soloviev, Dorota Szpak,
Christian Weber and Edward F. Plow, Neutrophil Apoptosis:
Selective Regulation by Different Ligands of Integrin ␣M␤2,
J. Immunol, 181, 3609-3619 (2008).
Esen Goksoy, Yan-Qing Ma, Xiaoxia Wang, Xiangming
Kong, Dhanuja Perera, Edward F. Plow and Jun Qin, Structural basis for the autoinhibition of talin in regulating integrin
activation, Mol. Cell, 31, 124-133 (2008).
QIN, JUN (b.1962) CCF Professor. B.S, 1984, Nanjing
Normal University; Ph.D, 1992, University of California.
Fellow, 1993-1996, NIH. NMR Spectroscopy; Structural
Biology. Our laboratory is engaged in using NMR and
other analytical methods to study integrin transmembranesignaling—a fundamental process that trasmits mechanical and biochemical information between extracellular matrix and intracellular cytoskeleton. Our studies
are at atomic level, which not only help to understand the
mechanism of integrin signaling but also may facilitate
the structure-based development of therapeutic agents for
relevant diseases. TEL: (216) 444-5392 FAX: (216) 4451466
Web: www.ccf.org
Email: [email protected]
Z. Xu, T. Fukuda, X. Zha, J. Qin and C. Wu, Molecular
dissection of PINCH-1 reveals a mechanism of coupling and
uncoupling of cell shape modulation and survival, J. Biol.
Chem, 280, 27631-27637 (2005).
J. Vaynberg, T. Fukuda, K. Chen, O. Vinogradova, A. Velyvis, Y. Tu, L. Ng, C. Wu and J. Qin, Structure of an ultra
weak protein-protein complex and its crucial role in regulation of cell morphology and motility, Molecular Cell, 17,
513-523 (2005).
S. De, O. Razorenova, N. McCabe, T. O’Toole, J. Qin and
T. Byzova, Integrin activation and clustering controls tumor
growth and vascularization, P.N.A.S, 102, 7589-7594 (2005).
Z. Xu, K. I. Devlin, J. C. Nix, M. G. Ford, J. Qin and S.
Misra, Structure and interactions of the helical and U-Box
domains of CHIP, C-terminal of HSP70 interacting protein,
Biochemistry, 45, 4749-4759 (2006).
Y. Q. Ma, J. Yang, M. Pesho, O. Vinogradova, J. Qin and
E. F. Plow, Molecular insight into the regulation of integrin
alphaIIbbeta3 activation by distinct regions of its cytoplasmic
tails, Biochemistry, 45, 6656-6662 (2006).
K. Ding, S. Ithychanda and J. Qin, 3D correlated accordion
NMR spectroscopy of proteins, J. Mag. Reson, 180, 203-209
(2006).
X. Kong, X. Wang, S. Misra and J. Qin, Structural basis
for the phosphorylation-regulated focal adhesion targeting of
type Igamma phosphatidylinositol phosphate kinase (PIPKIgamma) by talin, J. Mol. Biol, 359, 47-54 (2006).
S. Li, G. Peters, K. Ding, X. Zhang, J. Qin and G. Sen,
Molecular basis of PKR activation by PACT, P.N.A.S, 103,
10005-10010 (2006).
R. P. Barnwal, T. R. Chaudhuri, S. Nanduri, J. Qin and K.
V. R. Chary, Methyl dynamics for understanding hydrophobic core packing of dynamically different motifs of
dsRBD of PKR, Proteins, 62, 501-508 (2006).
J. Vaynberg and J. Qin, Weak protein-protein interactions
by NMR, Trends in Biotechnology, 24, 22-27 (2006).
X. M. Li, R. G. Salomon, J. Qin and S. L. Hazen, Conformation of an endogenous oxidized phospholipid ligand for
the macrophage scavenger receptor CD36, Biochemistry, 46,
5009-5017 (2007).
Y. Q. Ma, J. Qin and E. F. Plow, Platelet integrin alphaIIbbeta3: Activation mechanisms, J Thromb Haemost, 5,
1345-1352 (2007).
X. Shi, Y. Tu, K. Chen, S. Wu, K. Fukuda, Y. Q. Ma, J.
Qin, E. F. P. Plow and C. Wu, The mitogen inducible gene-2
(Mig-2)-integrin interaction promotes cytoskeletal strengthening of cell-matrix adhesion and modulates cell motility, J.
Biol. Chem, 282, 20455-20466 (2007).
L. Deshmukh, S. Tyukhtenko, J. M. Liu, J. Fox, J. Qin and
O. Vinogradova, Molecular insight into the interaction between platelet integrin alphaIIbbeta3 and cytoskeletal protein
skelemin, J. Biol. Chem, 282, 32349-32356 (2007).
W. Wang, X. Liao, K. Fukuda, S. Knappe, F. Wu, D. L.
Dries, J. Qin and Q. Y. Wu, Corin variant associated with hypertension and cardiac hypertrophy exhibits impaired zymogen activation and pro-atrial natriuretic peptide processing
activity, Circulation Research, 103, 502-508 (2008).
X. Wang, K. Fukuda, I. J. Byeon, A. Velyvis, C. Wu, A.
M. Gronenborn and J. Qin, The structure of alpha-Parvin
CH2-Paxillin LD1 complex reveals a novel modular recognition for focal adhesion assembly, J. Biol. Chem, 283, 211321119 (2008).
M. E. Greenberg, X. M. Li, B. G. Gugiu, X. D. Gu, J. Qin,
R. G. Salomon and S. L. Hazen, The lipid whisker model of
the structure of peroxidized cell membranes, J. Biol. Chem,
283, 2385-96 (2008).
Y. Ma, J. Qin, C. Wu and E. F. Plow, Kindlin-2 supports
talin for integrin activation, J. Cell Biol, 181, 439-46 (2008).
E. Goksoy, Y. Q. Ma, X. Kong, D. Perera, E. F. Plow and
J. Qin, Structural basis for the autoinhibition of talin in regulating integrin activation, Molecular Cell, 31, 124-133
(2008).
Xiang-ming Kong, A structural mechanism for spatial and
temporal localization of phosphatidylinositol-4,5-bisphosphate into focal adhesions and NMR technique improvement.
(D)
SILVERMAN, ROBERT H. (b.1948) CCF Professor. B.S, 1970, Michigan State University; Ph.D, 1977,
Iowa State University. Postdoctoral Fellow, 1977-1979,
Roche Institute for Molecular Biology; Postdoctoral Fellow, 1980-1981, Imperial Cancer Res. Fund. Biochemical pathways of interferon action; control of RNA turnover; innate immunity; prostate cancer pathogenesis, targeted therapy of human diseases. TEL: (216) 445-9650
FAX: (216) 445-6269
Web: www.lerner.ccf.org/pi/silverma.html
Email: [email protected]
Publication list has not been verified by the department.
Catherine Bisbal and Robert H. Silverman, Diverse functions of RNase L and implications in pathology, Biochimie,
89, 789-798 (2007).
Robert H. Silverman, A scientific journey through the 25A/RNase L system, Cytokine Growth Factor Rev, 18, 381388 (2007).
Robert H. Silverman, Viral encounters with 2’,5’-oligoadenylate synthetase and RNase L during the interferon antiviral
response, J. Virol, 81, 12720-12729 (2007).
Jian-Qiu Han, Hannah L. Townsend, Babal Kant Jha, Jayashree M. Paranjape, Robert H. Silverman and David J. Barton, A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L, J. Virol, 81, 5561-5572 (2007).
Scott E. Hensley, Ann S. Cun, Wynetta Giles-Davis, Yan
Li, Zhiquan Xiang, Marcio O. Lasaro, Bryan R. G. Williams,
Robert H. Silverman and Hildegund C. J. Ertl, Type I Interferon Inhibits Antibody Responses Induced by a Chimpanzee
Adenovirus Vector, Mol. Ther, 15, 393-403 (2007).
Ernest C. Borden, Ganes C. Sen, Gilles Uze, Robert H. Silverman, Richard M. Ransohoff, Graham R. Foster and
George R. Stark, Interferons at age 50: past, current and future impact on biomedicine, Nat. Rev. Drug Discovery, 6,
975-990 (2007).
Krishnamurthy Malathi, Beihua Dong, Michael Gale, Jr.
and Robert H. Silverman, Small self-RNA generated by
RNase L amplifies antiviral innate immunity, Nature (London, U. K.), 448, 816-819 (2007).
Hagen Cramer, James R. Okicki, Taikyun Rho, Xinning
Wang, Robert H. Silverman and Warren D. W. Heston, 2-5A
Ligands—A New Concept for the Treatment of Prostate Cancer, Nucleosides, Nucleotides Nucleic Acids, 26, 1471-1477
(2007).
Beihua Dong, Sanggu Kim, Seunghee Hong, Jaydip Das
Gupta, Krishnamurthy Malathi, Eric A. Klein, Don Ganem,
Joseph L. DeRisi, Samson A. Chow and Robert H. Silverman, An infectious retrovirus susceptible to an IFN antiviral
pathway from human prostate tumors, Proc. Natl. Acad. Sci.
U. S. A, 104, 1655-1660 (2007).
Chandar S. Thakur, Babal Kant Jha, Beihua Dong, Jaydip
Das Gupta, Kenneth M. Silverman, Hongxia Mao, Hiro Sawai, Akiko O. Nakamura, Amiya K. Banerjee, Andrei Gudkov and Robert H. Silverman, Small-molecule activators of
RNase L with broad-spectrum antiviral activity, Proc. Natl.
Acad. Sci. U. S. A, 104, 9585-9590 (2007).
Christopher L. Washenberger, Jian-Qiu Han, Katherina J.
Kechris, Babal Kant Jha, Robert H. Silverman and David J.
Barton, Hepatitis C virus RNA: Dinucleotide frequencies and
cleavage by RNase L, Virus Res, 130, 85-95 (2007).
Hongxia Mao, Chandar S. Thakur, Santanu Chattopadhyay, Robert H. Silverman, Andrei Gudkov and Amiya K.
Banerjee, Inhibition of human parainfluenza virus type 3 infection by novel small molecules, Antiviral Res, 77, 83-94
(2008).
Arindam Chakrabarti, Anthony J. Sadler, Niladri Kar, Howard A. Young, Robert H. Silverman and Bryan R. G. Williams, Protein Kinase R-dependent Regulation of Interleukin10 in Response to Double-stranded RNA, J. Biol. Chem, 283,
25132-25139 (2008).
Sanggu Kim, Namshin Kim, Beihua Dong, David Boren,
Serena A. Lee, Jaydip Das Gupta, Christina Gaughan, Eric
A. Klein, Christopher Lee, Robert H. Silverman and Samson
A. Chow, Integration site preference of xenotropic murine
leukemia virus-related virus, a new human retrovirus associated with prostate cancer, J. Virol, 82, 9964-9977 (2008).
Beihua Dong, Robert H. Silverman and Eugene S. Kandel,
A natural human retrovirus efficiently complements vectors
based on Murine Leukemia Virus, PLoS One, 3, No pp. given (2008).
Hannah L. Townsend, Babal K. Jha, Jian-Qiu Han, N. Karl
Maluf, Robert H. Silverman and David J. Barton, A viral
RNA competitively inhibits the antiviral endoribonuclease
domain of RNase L, RNA, 14, 1026-1036 (2008).
SILVERSTEIN, ROY (b.1953) Professor and Dept
Chair. B.Sc, 1975, Brown University; M.D, 1979, Emory
University. Fellow in Hematology/Oncology, 19821986, Cornell Medical College. Biochemistry; Cell Biology. We are interested in developmental vascular biology, particularly in the molecular pathogenesis of atherosclerosis, aberrant angiogenesis, inflammation, and
thrombosis. We are actively studying cellular phagocytic
and adhesion receptors, such as CD36, and are interested
in how cells regulate expression of these molecules, the
mechanisms by which these receptors transmit cellular
signals, and the structural basis of ligand recognition.
TEL: (216) 444-5220 FAX: (216) 444-9404
Web: www.lerner.ccf.org/cellbio/silverstein/
Email: [email protected]
Publication list has not been verified by the department.
Ella Guy, Sai Kuchibhotla, Roy Silverstein and Maria Febbraio, Continued inhibition of atherosclerotic lesion development in long term Western diet fed CD36°/apoE° mice, Atherosclerosis (Amsterdam, Neth.), 192, 123-130 (2007).
Elaine Y. Chung, Jianguo Liu, Yoichiro Homma, Yunhua
Zhang, Andrea Brendolan, Matilde Saggese, Jihong Han,
Roy Silverstein, Licia Selleri and Xiaojing Ma, Interleukin10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and
Prep-1, Immunity, 27, 952-964 (2007).
SMITH, JONATHAN (b.1955) CCF Professor. B.A,
1978, University of California, Santa Cruz; Ph.D, 1984,
Harvard. Postcoc, 1984-1991, Rockefeller University.
Biochemistry; Cell Biology. Cholesterol metabolism in
acrophages. Cholesterol and lipid efflux via ABCA1.
ApoAI structure, function, and HDL biogenesis and metabolism. Genes affecting atherosclerosis susceptibility
in mice, quantitative trait locus analysis. Expression microarrays and bioinformatic approach to disease gene
discovery. Drug discovery for the prevention of Alzheimer disease. TEL: (216) 444-2248 FAX: (216) 4449404
Web: www.lerner.ccf.org/cellbio/smith/
Email: [email protected]
Publication list has not been verified by the department.
Lia M. Haynes, Congrong Miao, Jennifer L. Harcourt, Joel
M. Montgomery, Mai Quynh Le, Sergey A. Dryga, Kurt I.
Kamrud, Bryan Rivers, Gregory J. Babcock, Jennifer Betts
Oliver, James A. Comer, Mary Reynolds, Timothy M. Uyeki,
Daniel Bausch, Thomas Ksiazek, William Thomas, Harold
Alterson, Jonathan Smith, Donna M. Ambrosino and Larry J.
Anderson, Recombinant protein-based assays for detection of
antibodies to severe acute respiratory syndrome coronavirus
spike and nucleocapsid proteins, Clin. Vaccine Immunol, 14,
331-333 (2007).
STARK, GEORGE ROBERT (b.1933) CCF Professor. A.B, 1955, Columbia College; Ph.D, 1959, Columbia University. Research Associate, 1959-1963, Rockefeller University. Biological chemistry; cell and molecular biology; analysis of signaling pathways in mammalian cells; techniques include genetics, biochemistry,
structural and functional analysis of proteins; pathways
studied include interferons, interleukin-1, tumor necrosis
factor, tumor suppressor p53. TEL: (216) 444-6062
FAX: (216) 444-3279
Web: www.lerner.ccf.org/molecbio/stark/
CLEVELAND STATE
Email: [email protected]
No publication information submitted for this edition.
STUEHR, DENNIS J. (b.1958) CCF Professor. B.Sc,
1980, Bowling Green State University; Ph.D, 1986, Massachusetts Institute of Technology. Postdoctoral Fellow,
1987-1989, Cornell University Medical College. Regulation of biological electron transfer, nitric oxide biosynthesis, studies on the mechanism and regulation of flavoheme enzymes like NO synthases and NADPH oxidases
using crystallography, molecular biology, mutagensis
and spectroscopy; mechanism of enzyme assembly in
cells, cofactor insertion and subunit interaction. TEL:
(216) 445-6950 FAX: (216) 444-9329
Email: [email protected]
Publication list has not been verified by the department.
Sougata Sinha Ray, Jesus Tejero, Zhi-Qiang Wang, Tanmay Dutta, Arindam Bhattacharjee, Michael Regulski, Tim
Tully, Sanjay Ghosh and Dennis J. Stuehr, Oxygenase Domain of Drosophila melanogaster Nitric Oxide Synthase:
Unique Kinetic Parameters Enable a More Efficient NO Release, Biochemistry, 46, 11857-11864 (2007).
Sougata Sinha Ray, Rajib Sengupta, Mauro Tiso, Mohammad Mahfuzul Haque, Rupam Sahoo, David W. Konas, Kulwant Aulak, Michael Regulski, Tim Tully, Dennis J. Stuehr
and Sanjay Ghosh, Reductase Domain of Drosophila melanogaster Nitric-Oxide Synthase: Redox Transformations, Regulation, and Similarity to Mammalian Homologues, Biochemistry, 46, 11865-11873 (2007).
Edward Beaumont, Jean-Christophe Lambry, Zhi-Qiang
Wang, Dennis J. Stuehr, Jean-Louis Martin and Anny SlamaSchwok, Distal Val346Ile Mutation in Inducible NO Synthase Promotes Substrate-Dependent NO Confinement, Biochemistry, 46, 13533-13540 (2007).
Mauro Tiso, Jesus Tejero, Koustubh Panda, Kulwant S.
Aulak and Dennis J. Stuehr, Versatile Regulation of Neuronal Nitric Oxide Synthase by Specific Regions of Its C-Terminal Tail, Biochemistry, 46, 14418-14428 (2007).
David Li, Mariam Kabir, Dennis J. Stuehr, Denis L. Rousseau and Syun-Ru Yeh, Substrate- and Isoform-Specific Dioxygen Complexes of Nitric Oxide Synthase, J. Am. Chem.
Soc, 129, 6943-6951 (2007).
Amandine Marechal, Tony A. Mattioli, Dennis J. Stuehr
and Jerome Santolini, Activation of Peroxynitrite by Inducible Nitric-oxide Synthase: A Direct Source of Nitrative
Stress, J. Biol. Chem, 282, 14101-14112 (2007).
Zhi-Qiang Wang, Rachel J. Lawson, Madhavan R. Buddha, Chin-Chuan Wei, Brian R. Crane, Andrew W. Munro
and Dennis J. Stuehr, Bacterial Flavodoxins Support Nitric
Oxide Production by Bacillus subtilis Nitric-oxide Synthase,
J. Biol. Chem, 282, 2196-2202 (2007).
Davin Jagnandan, Jarrod E. Church, Botond Banfi, Dennis
J. Stuehr, Mario B. Marrero and David J. R. Fulton, Novel
Mechanism of Activation of NADPH Oxidase 5: Calcium
sensitization via phosphorylation, J. Biol. Chem, 282, 64946507 (2007).
Weiling Xu, Thomas Koeck, Abigail R. Lara, Donald Neumann, Frank P. Difilippo, Michelle Koo, Allison J. Janocha,
Fares A. Masri, Alejandro C. Arroliga, Constance Jennings,
Raed A. Dweik, Rubin M. Tuder, Dennis J. Stuehr and Serpil
C. Erzurum, Alterations of cellular bioenergetics in pulmonary artery endothelial cells, Proc. Natl. Acad. Sci. U. S. A,
104, 1342-1347 (2007).
Mohammad Mahfuzul Haque, Koustubh Panda, Jesus
Tejero, Kulwant S. Aulak, Mohammed Adam Fadlalla, Anthony T. Mustovich and Dennis J. Stuehr, A connecting
hinge represses the activity of endothelial nitric oxide synthase, Proc. Natl. Acad. Sci. U. S. A, 104, 9254-9259 (2007).
Chin-Chuan Wei, Zhi-Qiang Wang, Jesus Tejero, Ya-Ping
Yang, Craig Hemann, Russ Hille and Dennis J. Stuehr, Catalytic reduction of a tetrahydrobiopterin radical within nitricoxide synthase, J. Biol. Chem, 283, 11734-11742 (2008).
Ivan Gusarov, Marina Starodubtseva, Zhi-Qiang Wang,
Lindsey McQuade, Stephen J. Lippard, Dennis J. Stuehr and
Evgeny Nudler, Bacterial Nitric-oxide Synthases Operate
without a Dedicated Redox Partner, J. Biol. Chem, 283,
13140-13147 (2008).
Ivan Gusarov, Marina Starodubtseva, Zhi-Qiang Wang,
Lindsey McQuade, Stephen J. Lippard, Dennis J. Stuehr and
Evgeny Nudler, Bacterial nitric-oxide synthases operate
without a dedicated redox partner. [Erratum to document cited in CA149:047515], J. Biol. Chem, 283, 19164 (2008).
Robielyn P. Ilagan, Mauro Tiso, David W. Konas, Craig
Hemann, Deborah Durra, Russ Hille and Dennis J. Stuehr,
Differences in a Conformational Equilibrium Distinguish Catalysis by the Endothelial and Neuronal Nitric-oxide Synthase Flavoproteins, J. Biol. Chem, 283, 19603-19615
(2008).
Mauro Tiso, Andreas Strub, Christian Hesslinger, Claire T.
Kenney, Rainer Boer and Dennis J. Stuehr, BYK191023 (2[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthase, Mol. Pharmacol, 73,
1244-1253 (2008).
SUN, XUE-LONG (b.1965) Associate Professor. B.S,
1988, ShenYang Pharmaceutical University; Ph.D, 1997,
Kitasato University. Special Research Fellow, 19972000, RIKEN; Research Associate, 2000-2002, Emory
University. Carbohydrate Chemistry; Medicinal and/or
Pharmaceutical Chemistry. The main research interests
in my lab are: To develop intelligent identification and
detection system for discovery of cardiovascular disease
biomarkers, and to explore vascular pathological and surgical interventional sites-local/targeted antithrombotic
drug delivery. TEL: (216) 687-3919 FAX: (216) 6879298
Web: www.csuohio.edu/chemsitry
Email: [email protected]
Cherie L. Stabler, Xue-Long Sun, Wanxing Cui, John T.
Wilson, Carolyn A. Haller and Elliot L. Chaikof, Surface Reengineering of Pancreatic Islets with Recombinant azidoThrombomodulin, Bioconjugate Chem, 18, 1713-1715
(2007).
Xue-Long Sun, Recent anti-influenza strategies in multivalent sialyloligosaccharides and sialylmimetics approaches,
Curr. Med. Chem, 14, 2304-2313 (2007).
Xue-Long Sun, Functional glyco-affinity precipitation for
enhanced glyco-proteomics, Current Proteomics, 5, 202-210
(2008).
Xue-Long Sun, LiuChun Yang and Elliot L. Chaikof, Chemoselective immobilization of biomolecules through aqueous
Diels-Alder and PEG chemistry, Tetrahedron Lett, 49, 25102513 (2008).
TRAPP, BRUCE D. (b.1950) CCF Professor. Ph.D,
1977, Loyola University, Stritch SOM. Staff Fellow,
1976-1980, Laboratory of Neuropathology and Neuroanatomical Sciences, NINCDS, NIH; Senior Staff Fellow,
1980-1984, Infectious Diseases Branch and Laboratory
of Molecular Genetics, NINCDS, NIH. The objective of
our research effort is two-fold. The first is to obtain a
better understanding of cellular and molecular events involved in glial cell development and myelin formation in
the central and peripheral nervous systems. The second
is to understand how myelin, myelin-forming cells, and
axons are destroyed in autoimmune demyelinating diseases and how gene mutations cause dysmyelination. A
common theme of these research programs is that novel
information about the normal function of myelin-forming
cells and myelin-axon interactions will help us understand the mechanisms involved in human diseases which
destroy myelin, myelin-forming cells, axons and neurons. TEL: (216) 444-7177 FAX: (216) 444-7927
Email: [email protected]
Publication list has not been verified by the department.
Joel A. Black, Jia Newcombe, Bruce D. Trapp and Stephen
G. Waxman, Sodium channel expression within chronic multiple sclerosis plaques, J. Neuropathol. Exp. Neurol, 66, 828837 (2007).
Bruce D. Trapp and Klaus-Armin Nave, Multiple sclerosis:
an immune or neurodegenerative disorder?, Annu. Rev. Neurosci, 31, 247-269 (2008).
Klaus-Armin Nave and Bruce D. Trapp, Axon-glial signaling and the glial support of axon function, Annu. Rev. Neurosci, 31, 535-561 (2008).
Bruce D. Trapp, Rescue of congenital hypomyelination by
progenitor cell transplantation, Cell Stem Cell, 2, 519-520
(2008).
Xiangyou Hu, Wanxia He, Claudiu Diaconu, Xiaoying
Tang, Grahame J. Kidd, Wendy B. Macklin, Bruce D. Trapp
and Riqiang Yan, Genetic deletion of BACE1 in mice affects
remyelination of sciatic nerves, FASEB J, 22, 2970-2980
(2008).
Xinghua Yin, Grahame J. Kidd, Klaus-Amin Nave and
Bruce D. Trapp, P0 protein is required for and can induce formation of Schmidt-Lantermann incisures in myelin internodes, J. Neurosci, 28, 7068-7073 (2008).
TURNER, JOHN F., II (b.1968) Associate Professor.
B.S, 1990, Youngstown State University; Ph.D, 1998,
University of Pittsburgh. Functional Chemical Imaging,
1998-1999, Carnegie Mellon University. Analytical
Chemistry; Biomaterials. Chemical Imaging (Widefield
Raman, fluorescence, UV-Vis, and IR); studies employ
novel electro-optic devices (Acousto-Optic Tunable Filters and Liquid Crystal Tunable Filters); applications include disease diagnosis and assessment, and growth and
repair mechanisms of tissues grown on artificial scaffolds; additional research areas include polymer and
semiconductor materials characterization, geological
mineral characterization, and new methods for data visualization and chemometric analysis. TEL: (216) 6872465 FAX: (216) 687-9298
Web: bigsky.asic.csuohio.edu/
Email: [email protected]
No publication information submitted for this edition.
WANG, QING K. (b.1965) CCF Professor. Ph.D,
1993, Cornell University. Associate, 1993-1996, Howard
Hughes Medical Institute and University of Utah. Biochemistry; Genetics. Protein-protein interactions, Gene
regulation, Structure and function of transcriptional factors, Structure and function of ion channels, Structure
and function of angiogenic factor AGGF1, Molecular ge-
7
netics of human disease. TEL: (216) 445-0570 FAX:
(216) 636-1231
Web: www.lri.ccf.org/moleccard/wang/
Email: [email protected]
Publication list has not been verified by the department.
Gong-Qing Shen, Lin Li, Domenico Girelli, Sara B. Seidelmann, Shaoqi Rao, Chun Fan, Jeong Euy Park, Quansheng Xi, Jing Li, Ying Hu, Oliviero Olivieri, Kandice Marchant, John Barnard, Roberto Corrocher, Robert Elston, June
Cassano, Susan Henderson, Stanley L. Hazen, Edward F.
Plow, Eric J. Topol and Qing K. Wang, An LRP8 variant is
associated with familial and premature coronary artery disease and myocardial infarction, Am. J. Hum. Genet, 81, 780791 (2007).
Sandro L. Yong, Ying Ni, Teng Zhang, David J. Tester,
Michael J. Ackerman and Qing K. Wang, Characterization of
the cardiac sodium channel SCN5A mutation, N1325S, in single murine ventricular myocytes, Biochem. Biophys. Res.
Commun, 352, 378-383 (2007).
Teng Zhang, Sandro L. Yong, Xiao-Li Tian and Qing K.
Wang, Cardiac-specific overexpression of SCN5A gene leads
to shorter P wave duration and PR interval in transgenic
mice, Biochem. Biophys. Res. Commun, 355, 444-450
(2007).
Ling Wu, Stephen R. Archacki, Teng Zhang and Qing K.
Wang, Induction of high STAT1 expression in transgenic
mice with LQTS and heart failure, Biochem. Biophys. Res.
Commun, 358, 449-454 (2007).
Xiao-Li Tian, Yuanna Cheng, Teng Zhang, Mei-Ling
Chang Liao, Sandro L. Yong and Qing K. Wang, Optical
mapping of ventricular arrhythmias in LQTS mice with
SCN5A mutation N1325S, Biochem. Biophys. Res. Commun,
352, 879-883 (2007).
Xianqin Zhang, Lanying Chen, Jingyu Liu, Zhen Zhao, Erjun Qu, Xiaotao Wang, Wei Chang, Chengqi Xu, Qing K.
Wang and Mugen Liu, A novel DSPP mutation is associated
with type II dentinogenesis Imperfecta in a Chinese family,
BMC Med. Genet, 8, No pp. given (2007).
Wei Chang, Qianbin Ding, Zhaohui Tang, Ping Liu, Fagang Jiang, Tie Ke, Xiang Ren, Zhi Wang, Jingyu Liu, Qing
K. Wang and Mugen Liu, A novel de novo frameshift mutation of RPGR ORF15 is associated with X-linked retinitis
pigmentosa in a Chinese family, Mol. Vision, 13, 1548-1554
(2007).
Gong-Qing Shen, Lin Li, Shaoqi Rao, Kalil G. Abdullah,
Ji Min Ban, Bok-Soo Lee, Jeong Euy Park and Qing K.
Wang, Four SNPs on Chromosome 9p21 in a South Korean
Population Implicate a Genetic Locus That Confers High
Cross-Race Risk for Development of Coronary Artery Disease, Arterioscler., Thromb., Vasc. Biol, 28, 360-365 (2008).
Jing Yu Liu, Xiaohua Dai, Jiqun Sheng, Xin Cui, Xu
Wang, Xueqing Jiang, Xin Tu, Zhaohui Tang, Yan Bai, Mugen Liu and Qing K. Wang, Identification and functional
characterization of a novel splicing mutation in RP gene
PRPF31, Biochem. Biophys. Res. Commun, 367, 420-426
(2008).
Hui Li, Chang Li, Qiulun Lu, Ting Su, Tie Ke, David
Wan-Cheng Li, Mingxiong Yuan, Jingyu Liu, Xiang Ren,
Zhihong Zhang, Shaoqiong Zeng, Qing K. Wang and Mugen
Liu, Cataract mutation P20S of ␣B-crystallin impairs chaperone activity of ␣A-crystallin and induces apoptosis of human
lens epithelial cells, Biochim. Biophys. Acta, Mol. Basis Dis,
1782, 303-309 (2008).
Ping Liu, Shouyan Zhang, Qi Yao, Xiangyang Liu, Xu
Wang, Changzheng Huang, Xinyuan Huang, Pengyun Wang,
Mingxiong Yuan, Jing Yu Liu, Qing K. Wang and Mugen
Liu, Identification of a genetic locus for autosomal dominant
disseminated superficial actinic porokeratosis on chromosome 1p31.3-p31.1, Hum. Genet, 123, 507-513 (2008).
Ping Liu, Qingyu Yang, Xu Wang, Aiping Feng, Tao
Yang, Rong Yang, Pengyun Wang, Mingxiong Yuang, Mugen Liu, Jing Yu Liu and Qing K. Wang, Identification of a
Genetic Locus for Ichthyosis Vulgaris on Chromosome
10q22.3-q24.2, J. Invest. Dermatol, 128, 1418-1422 (2008).
Shirong Zhang, Lejin Wang, Yansheng Hao, Pengyun
Wang, Ping Hao, Ke Yin, Qing K. Wang and Mugen Liu,
T14484C and T14502C in the mitochondrial ND6 gene are
associated with Leber’s hereditary optic neuropathy in a Chinese family, Mitochondrion, 8, 205-210 (2008).
WEI, ROBERT (b.1939) Associate Professor. A.B,
1961, George Washington University; Ph.D, 1972,
George Washington University. Clinical Chemistry,
1972-1974, Georgetown University. Degradation of halogenated organic compounds. TEL: (216) 687-2421
FAX: (216) 687-9298
Email: [email protected]
Publication list has not been verified by the department.
K. A. S. Pathiratne, O. C. P. De Silva, David Hehemann,
Ian Atkinson and Robert Wei, Occurrence and Distribution
of Polycyclic Aromatic Hydrocarbons (PAHs) in Bolgoda
and Beira Lakes, Sri Lanka, Bull. Environ. Contam. Toxicol,
79, 135-140 (2007).
M. Ellen Matthews, Ian Atkinson, Lubaina Presswala,
Omar Najjar, Nadine Gerhardstein, Robert Wei, Elizabeth
Rye and Alan T. Riga, Defining phase transitions and electrical behavior of Dand Lamino acids by thermal and analytical
methods, Proc. NATAS Annu. Conf. Therm. Anal. Appl, 35th,
04#333/1-10 (2007).
8
CLEVELAND STATE
Lubaina Presswala, M. Ellen Matthews, Ian Atkinson,
Omar Najjar, Nadine Gerhardstein, John Moran, Robert Wei
and Alan T. Riga, Hydration of crystalline amino acids with
bound and unbound water revealed by thermal analysis,
Proc. NATAS Annu. Conf. Therm. Anal. Appl, 35th, 04#533/
1-13 (2007).
Mary C. January, Teresa J. Cutright, Harry Van Keulen
and Robert Wei, Hydroponic phytoremediation of Cd, Cr, Ni,
As, and Fe: Can Helianthus annuus hyperaccumulate multiple heavy metals?, Chemosphere, 70, 531-537 (2008).
Harry van Keulen, Robert Wei and Teresa J. Cutright, Arsenate-induced expression of a class III chitinase in the dwarf
sunflower Helianthus annus, Environ. Exp. Bot, 63, 281-288
(2008).
XU, YAN (b.1958) Professor. B.S, 1982, Zhongshan
University; M.S, 1987, California State University, Fresno; Ph.D, 1991, University of Cincinnati. Visiting Scientist, 2000-2001, National Cancer Institute. Bioanalytical
Chemistry; Pharmacology. Development and validation
of analytical methods (i.e., LC-MS, GC-MS, CE, and immunoassays, etc) for pre-clinical and clinical evaluation
of pharmacokinetic and pharmacodynamic endpoints and
for mechanistic study of cancer. TEL: (216) 687-3991
FAX: (216) 687-9298
Email: [email protected]
Melissa McCulloch, Xiang Zhou, Yan Xu, Steve Brunell
and Linda Spear, Determination of endocannabinoid receptor
antagonist SR141716 (rimonabant) in plasma by liquid chromatograph tandem mass spectrometry, J. Chromatogr., B:
Anal. Technol. Biomed. Life Sci, 863, 258-265 (2008).
Adrian Grozav, Mass spectrometry based strategies in biomedicine: Phosphoproteomics of topoisomerase II isozymes.
(D)
Alina D. Bulgar, New insights into molecular mechanism
of fludarabine. (D)
YADAV, SATYA P. (b.1945) Adjunct Faculty.
B.Sc.Agrc, 1967, University of Udaipur, Udaipur, India;
M.Sc, 1969, Indian Agril Res. Inst., Delhi, India; Ph.D,
1974, Indian Agril Res. Inst., Delhi, India. Research Associate, 1974-1975, International Crops Research Institute (ICRISAT), Hyderabad, India; Post-doctoral fellow,
1988-1990, University of Miami. Biochemistry; Structural Biology. The Molecular Biotechnology Core laboratory provides consultation and research support in the following areas: Protein Chemistry, identification and Sequencing; Peptide chemistry and amino acid; Peptide design and modifications; Multiple Antigen Peptides
(MAPs) and mass spectrometry analysis of synthetic
peptides; Biomolecular interaction analysis by Surface
Plasmon Respnance. Dr. Yadav collaborates with several
laboratories in these areas. TEL: (216) 445-7095 FAX:
(216) 636-0556
Web: www.lerner.ccf.org/services/molecbiotech/
Email: [email protected]
Rebecca L. Rich, Giuseppe A. Papalia, Peter J. Flynn, Jamie Furneisen, John Quinn, Joshua S. Klein, Phini S. Katsamba, M. Brent Waddell, Michael Scott, Joshua Thompson, Judie Berlier, Schuyler Corry, Mireille Baltzinger, Gabrielle
Zeder-Lutz, Andreas Schoenemann, Anca Clabbers, Sebastien Wieckowski, Mary M. Murphy, Phillip Page, Thomas E.
Ryan, Jay Duffner, Tanmoy Ganguly, John Corbin, Satyen
Gautam, Gregor Anderluh, Andrej Bavdek, Dana Reichmann, Satya P. Yadav, Eric Hommema, Ewa Pol and Andrew Drake, A global benchmark study using affinity-based
biosensors, Analytical Biochemistry, (2008).
T. Y. Sam-Yellowe, T. L. Banks. H. Fujiko, J. A. Drazba
and S. P. Yadav, Plasmodium yoelii: Novel rhoptry proteins
identified within the body of merozoite rhoptries in rodent
Plasmodium malaria, Exptl Parasitol, 120, 113-117 (2008).
R. Jha, A. Agarwal, R. Mahfouz, U. Paasch, S. Grunewald,
E. Sabanegh, S. P. Yadav and R. H. Sharma, Determination
of Poly (ADP-Ribose) Polymerase (PARP) homologues in
human ejaculated sperm and its correlation with sperm maturation, Fertility and Sterility, 88, S362-S363 (2008).
ChangWoo Lee, Sumantha Bhatt, Anita Shukla, Russell
W. Desnoyer, Satya P. Yadav, Mijin Kim, Sei-Heon Jang
and Sadashiva S. Karnik, Site-specific cleavage of G proteincoupled receptor-engaged ␤-Arrestin: Influence of the AT1
receptor conformation on scissile site selection, J. Biol.
Chem, 283, 21612-21620 (2008).
S. P. Yadav, Highlights of Association for Biochemistry
and Molecular Biology Meeting During Experimental Biology 2008, Journal of Biotechnology, 19, 147-150 (2008).
ZHOU, AIMIN (b.1957) Assistant Professor. B.Sc,
1982, Zhongshan University; M.Sc, 1985, Institute of
Microbiology,CAS; Ph.D, 1998, Cleveland State University. Research follow, 1991-1995, Cleveland Clinic
Foundation; Research Associate, 1995-1999, Cleveland
Clinic Foundation; Project Scientist, 1999-2000, Cleveland Clinic Foundation. Research Interests: The main research interests of my laboratory are gene regulation by
2-5A dependent RNase L (RNase L) and the role of
RNase L in inflammatory diseases. RNase L is a mediator of interferon action against viral infection and cell
proliferation. Currently, we are exploring and investigating the regulation of expression of inflammatory genes
by RNase L, and using RNase L defective mice as a
model to study the role of RNase L in cancer and cardiovascular diseases. TEL: (216) 687-2416 FAX: (216) 6879298
Email: [email protected]
Publication list has not been verified by the department.
Wendy Liu, Shu-Ling Liang, Hongli Liu, Robert Silverman and Aimin Zhou, Tumour suppressor function of RNase
L in a mouse model, Eur. J. Cancer, 43, 202-209 (2007).
Lisam Shanjukumar Singh, Michael Berk, Rhonda Oates,
Zhenwen Zhao, Haiyan Tan, Ying Jiang, Aimin Zhou, Kashif
Kirmani, Rosemary Steinmetz, Daniel Lindner and Yan Xu,
Ovarian Cancer G Protein-Coupled Receptor 1, a New Metastasis Suppressor Gene in Prostate Cancer, J. Natl. Cancer
Inst, 99, 1313-1327 (2007).
Ning Wang, Chunhua Fu, Aimin Zhou and Zhaohua Sun,
Direct method for determining total organic acid in Xiaoshi
tablets for children by near infrared diffuse reflectance spectroscopy, Zhongguo Zhongyao Zazhi, 32, 1597-1598 (2007).
Yan Zhou, Crystal M. Weyman, Hongli Liu, Alexandru
Almassan and Aimin Zhou, IFN-␥ Induces Apoptosis in HL60 Cells Through Decreased Bcl-2 and Increased Bak Expression, J. Interferon Cytokine Res, 28, 65-72 (2008).
ZHOU, XIANG (b.1962) Mass Spectrometry Specialist. B.S, 1982, Jilin University, China; M.S, 1985, Chinese Academy of Sciences; Ph.D, 1989, Chinese Academy of Sciences. Research Associate, 1990-1995, Iowa
State University. Our laboratory’s research activities include: developing and using methods for drugs and metabolites in biological samples for pharmacokinetic and
other studies; investigating protein modifications (inhibition, oxidation, damage, mutation) and proteomics. The
major techniques that we use are chromatography and
mass spectrometry. TEL: (216) 523-7198 FAX: (216)
687-9298
Email: [email protected]
Publication list has not been verified by the department.
Xiang Zhou, Xiao-Bing Wang and Ling-Yi Kong, 4-Methyl-7-[3-(4-o-tolylpiperazin-1-yl)propoxy]-2H-chromen-2one, Acta Crystallogr., Sect. E: Struct. Rep. Online, E63,
o266-o267 (2007).
Xiaocheng Weng, Lige Ren, Liwei Weng, Jing Huang,
Shugao Zhu, Xiang Zhou and Linhong Weng, Synthesis and
biological studies of inducible DNA cross-linking agents,
Angew. Chem., Int. Ed, 46, 8020-8023 (2007).
Weihua Lin, Xiang Zhou, Guo Ping Wang and C. T. Chan,
Spatial Bloch oscillations of plasmons in nanoscale metal
waveguide arrays, Appl. Phys. Lett, 91, 243113/1-243113/3
(2007).
Lixia Zhang, Lige Ren, Minghui Bai, Liwei Weng, Jing
Huang, Lin Wu, Minggang Deng and Xiang Zhou, Synthesis
and biological activities of quinazoline derivatives with ortho-phenol-quaternary ammonium salt groups, Bioorg. Med.
Chem, 15, 6920-6926 (2007).
Li Yang, Feng Liang, Min Liu, Congyi Zheng, Shuhui
Wan, Xiaoqin Xiong, Xiaolian Zhang, Chao Shen and Xiang
Zhou, HeLa cells apoptosis induced by 1,7-dimethyl1,4,7,10-tetraazacyclododecane, Bioorg. Med. Chem. Lett,
17, 1818-1822 (2007).
Xiao-Cheng Weng, Jing Huang, Song Wu, Li-Ge Ren, LiWei Weng, Shu-Gao Zhu and Xiang Zhou, Specific recognition of loop DNA by dicationic porphyrins, Chem. Biodiversity, 4, 1501-1507 (2007).
An-Ming Zhang, Jing Huang, Xiao-Cheng Weng, Jin-Xi
Li, Li-Ge Ren, Zhi-Bin Song, Xiao-Qin Xiong, Xiang Zhou,
Xiao-Ping Cao and Yan Zhou, A water-soluble, octacationic
zinc phthalocyanine as molecular probe for nucleic acid secondary structure, Chem. Biodiversity, 4, 215-223 (2007).
Xiao-Qin Xiong, Feng Liang, Li Yang, Xiao-Lin Wang,
Xiang Zhou, Cong-Yi Zheng and Xiao-Ping Cao, Transcription-inhibition and antitumor activities of N-alkylated tetraazacyclododecanes, Chem. Biodiversity, 4, 2791-2797
(2007).
Xiao-Qin Xiong, Feng Liang, Li Yang, Xiang Zhou, CongYi Zheng and Xiao-Ping Cao, Synthesis and biological studies of N-alkylated cyclic diamines, Chem. Biodiversity, 4, 4351 (2007).
Tian Tian, Xiao-Cheng Weng, Yang Song, Li-Xia Zhang,
Xiang Zhou and Yi Wang, Medicinal studies of dimeric phenols with multiple quaternary-ammonium pendant arms,
Chem. Biodiversity, 4, 947-954 (2007).
Boqiao Fu, Jing Huang, Lige Ren, Xiaocheng Weng, Yangyang Zhou, Yuhao Du, Xiaojun Wu, Xiang Zhou and Guangfu Yang, Cationic corrole derivatives: a new family of Gquadruplex inducing and stabilizing ligands, Chem. Commun.
(Cambridge, U. K.), 3264-3266 (2007).
Yupei Shan, Xiaobing Wang, Xiang Zhou, Lingyi Kong
and Masatake Niwa, Two minor diterpene glycosides and an
eudesman sesquiterpene from Coleus forskohlii, Chem.
Pharm. Bull, 55, 376-381 (2007).
Lige Ren, Anming Zhang, Jing Huang, Ping Wang, Xiaocheng Weng, Lixia Zhang, Feng Liang, Zheng Tan and
Xiang Zhou, Quaternary ammonium zinc phthalocyanine: inhibiting telomerase by stabilizing G quadruplexes and induc-
ing G-quadruplex structure transition and formation, ChemBioChem, 8, 775-780 (2007).
Jia-Rong Lian, Yong-Bo Yuan and Xiang Zhou, Organic
light-emitting devices with a LiF hole blocking layer, Chin.
Phys. Lett, 24, 828-830 (2007).
Wen-li Zhu, Min Zhang, Xiang Zhou and Jin-long Cai, Effect of different desalting methods on quality changes of dehydrated Salicornia bigelovii, Ganzao Jishu Yu Shebei, 5,
293-298 (2007).
Xiang Zhou, Qingnan Zhao, Peng Wang and Xiujian Zhao,
Preparation of SnO2:Sb films on SiO2-coated soda-lime glass
by chemical vapor deposition method, Guisuanyan Xuebao,
35, 600-605 (2007).
Xiaocheng Weng, Liwei Weng, Minghui Bai, Yangyang
Zhou and Xiang Zhou, Studies of inducible DNA cross linking agents, Huaxue Jinzhan, 19, 1999-2005 (2007).
Hongqi Pang, Yongbo Yuan, Yunfei Zhou, Jiarong Lian,
Lingfang Cao, Jie Zhang and Xiang Zhou, ZnS/Ag/ZnS coating as transparent anode for organic light emitting diodes, J.
Lumin, 122, 587-589 (2007).
Yun-fei Zhou, Yong-bo Yuan, Ling-fang Cao, Jie Zhang,
Hong-qi Pang, Jia-rong Lian and Xiang Zhou, Improved stability of OLEDs with mild oxygen plasma treated PEDOT:
PSS, J. Lumin, 122, 602-604 (2007).
Jia-rong Lian, Yong-bo Yuan, Ling-fang Cao, Jie Zhang,
Hong-qi Pang, Yun-fei Zhou and Xiang Zhou, Improved efficiency in OLEDs with a thin Alq3 interlayer, J. Lumin, 122,
660-662 (2007).
Xiang Zhou, Wen-Jun Liu, Jian-Liang Ye and Pei-Qiang
Huang, Complementary Stereocontrolled Approaches to 2Pyrrolidinones Bearing a Vicinal Amino Diol Subunit with
Three Continuous Chiral Centers: A Formal Asymmetric
Synthesis of (-)-Detoxinine, J. Org. Chem, 72, 8904-8909
(2007).
Tian Tian, Xiang Zhou and Wing H. Chan, Design and
synthesis of Hg2+ sensing probe based on spirobenzopyran
derivatives, Lett. Org. Chem, 4, 362-365 (2007).
Xiang Zhou, Ya-ping Xu, Sheng-lin Ma, Jian-guo Feng
and Qi-chun Wei, The radiation-sensitizing effect of gefitinib
on non-small cell lung cancer A549 cell line, Linchuang
Zhongliuxue Zazhi, 12, 814-818, 821 (2007).
Xiang Zhou, J. Ramesh Babu, Susana da Silva, Qing Shu,
Isabella A. Graef, Tim Oliver, Toshifumi Tomoda, Tomomi
Tani, Marie W. Wooten and Fan Wang, Unc-51-like kinase
1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons, Proc. Natl. Acad. Sci.
U. S. A, 104, 5842-5847 (2007).
Hui-zhi Huang, Yi-lun Wu, Jiu-lai Tang, De Wu, Shi-bing
Yang, Xiao-rong Sheng, Xiao-yan Xu and Xiang Zhou, Effect of inoculating human cytomegalovirus pp65 DNA vaccine before pregnancy to block the intrauterine vertical transmission in mice, Shiyong Erke Linchuang Zazhi, 22, 777-779
(2007).
Xiang Zhou, Zhao-da Zhang, Bo-le Tian, Fang-hai Han,
Wei-ming Hu, Wei Jia and Hui-ming Lu, Experiment study
on the diagnostic value of bile K-ras gene mutation responsible to the hepatic metastasis of pancreatic cancer, Sichuan
Daxue Xuebao, Yixueban, 38, 309-311, 327 (2007).
Ling-xiang Meng, Wei-ming Hu, Zhao-da Zhang, Fang-hai
Han, Xiang Zhou, Wei Jia and Hui-min Lu, Experimental
study on immune tolerance induced by human Ad-CTLA-4Ig
in rats with pancreaticoduodenal transplantation, Sichuan
Daxue Xuebao, Yixueban, 38, 374-377 (2007).
Wei-ming Hu, Zhao-da Zhang, Fang-hai Han, Xiang Zhou,
Ling-xiang Meng and Neng-wen Ke, The Experimental research on the Perforin and Granzyme B expressions to the
early diagnostic value of acute rejection response after pancreatic transplantation, Sichuan Daxue Xuebao, Yixueban,
38, 88-92 (2007).
Xiang Zhou, Wen-Jun Liu, Jian-Liang Ye and Pei-Qiang
Huang, A versatile approach to pyrrolidine azasugars and homoazasugars based on a highly diastereoselective reductive
benzyloxymethylation of protected tartarimide, Tetrahedron,
63, 6346-6357 (2007).
Xiang Zhou, Wen-yuan Tang and Zheng-ming Zhu, Application of targeted molecular therapy and its drugs in treatment of glioblastoma, Xiandai Zhenduan Yu Zhiliao, 18, 106109 (2007).
Peng Wang, Qingnan Zhao, Xiang Zhou and Xiujian Zhao,
Influence of homo-buffer layer thickness on the structure and
optical and electrical properties of AZO thin films prepared
on glass substrates by magnetron sputtering, Xiyou Jinshu
Cailiao Yu Gongcheng, 36, 589-593 (2007).
Xiao-juan Zong, Hai-chang Wang, Xiang Zhou, Jin Yu,
Kang Cheng and Rong-hua Luan, Effects of oxidized lowdensity lipoprotein on proliferation, apoptosis and cell function of endothelial progenitor cells of bone marrow, Zhonghua Laonian Xin Nao Xueguanbing Zazhi, 9, 119-121
(2007).
Di Xu, Xiang Zhou and Xiangke Wang, Adsorption and
desorption of Ni2+ on Na-montmorillonite: Effect of pH, ionic strength, fulvic acid, humic acid and addition sequences,
Appl. Clay Sci, 39, 133-141 (2008).
Xiang Zhou, Qin Li, Heng Lu, Hao Chen, Yiqing Guo,
Hanhua Cheng and Rongjia Zhou, Fish specific duplication
of Dmrt2: Characterization of zebrafish Dmrt2b, Biochimie,
90, 878-887 (2008).
Baoping Zhai, Li Shuai, Li Yang, Xiaocheng Weng, Lin
Wu, Shaoru Wang, Tian Tian, Xiaojun Wu, Xiang Zhou and
Congyi Zheng, Octa-Substituted Anionic Porphyrins: Topo-
CLEVELAND STATE
isomerase I Inhibition and Tumor Cell Apoptosis Induction,
Bioconjugate Chem, 19, 1535-1542 (2008).
Lixia Zhang, Jing Huang, Lige Ren, Minghui Bai, Lin Wu,
Baoping Zhai and Xiang Zhou, Synthesis and evaluation of
cationic phthalocyanine derivatives as potential inhibitors of
telomerase, Bioorg. Med. Chem, 16, 303-312 (2008).
Xiang Zhou, Xiao-Bing Wang, Tao Wang and Ling-Yi
Kong, Design, synthesis, and acetylcholinesterase inhibitory
activity of novel coumarin analogues, Bioorg. Med. Chem,
16, 8011-8021 (2008).
Xiang Zhou, Pan-Yuan Zhang, Jian-Liang Ye and PeiQiang Huang, A versatile approach to (4S,5R)-4-benzyloxy5-(␣-hydroxyalkyl)-2-pyrrolidinones: Experimental evidences to the computational predictions, C. R. Chim, 11, 5-18
(2008).
Guorui Li, Jing Huang, Ming Zhang, Yangyang Zhou, Dan
Zhang, Zhiguo Wu, Shaoru Wang, Xiaocheng Weng, Xiang
Zhou and Guangfu Yang, Bis(benzimidazole)pyridine derivative as a new class of G-quadruplex inducing and stabilizing
ligand, Chem. Commun. (Cambridge, U. K.), 4564-4566
(2008).
Zhibin Song, Xiaocheng Weng, Liwei Weng, Jing Huang,
Xiaolin Wang, Minghui Bai, Yangyang Zhou, Guangfu Yang
and Xiang Zhou, Synthesis and oxidation-induced DNA
cross-linking capabilities of bis(catechol) quaternary ammonium derivatives, Chem.—Eur. J, 14, 5751-5754 (2008).
Yong-bo Yuan, Jia-rong Lian and Xiang Zhou, Effect of
hole blocking layer on lifetime of organic light-emitting
diodes, Dianzi Qijian, 31, 25-28 (2008).
Shu-ming Chen, Yong-bo Yuan, Jia-rong Lian and Xiang
Zhou, Inverted top-emitting OLEDs with an n-type Si as
cathode, Dianzi Qijian, 31, 33-35, 39 (2008).
Jia-rong Lian, Yong-bo Yuan and Xiang Zhou, Improved
efficiency in OLEDs with a LiF interlayer in hole transport
layer, Dianzi Qijian, 31, 36-39 (2008).
Minggang Deng, Dan Zhang, Yangyang Zhou and Xiang
Zhou, Highly Effective Colorimetric and Visual Detection of
Nucleic Acids Using an Asymmetrically Split Peroxidase
DNAzyme, J. Am. Chem. Soc, 130, 13095-13102 (2008).
Lian Shan, James A. Hribar, Xiang Zhou and David J. Anderson, Gradient Chromatofocusing-Mass Spectrometry: A
New Technique in Protein Analysis, J. Am. Soc. Mass Spectrom, 19, 1132-1137 (2008).
Lucie Canaff, Xiang Zhou and Geoffrey N. Hendy, The
Proinflammatory Cytokine, Interleukin-6, Up-regulates Calcium-sensing Receptor Gene Transcription via Stat1/3 and
Sp1/3, J. Biol. Chem, 283, 13586-13600 (2008).
Xiang Zhou, Weiqing Ren and Weinan E, Adaptive minimum action method for the study of rare events, J. Chem.
Phys, 128, 104111/1-104111/11 (2008).
Melissa McCulloch, Xiang Zhou, Yan Xu, Steve Brunell
and Linda Spear, Determination of endocannabinoid receptor
antagonist SR141716 (rimonabant) in plasma by liquid chromatograph tandem mass spectrometry, J. Chromatogr., B:
Anal. Technol. Biomed. Life Sci, 863, 258-265 (2008).
Weiping Deng, Suqin Chen, Chun Lu, Xiang Zhou, Bin
Hu, Minghua Chen, Wei Lai and Yiming Wang, A novel
p.Gly1700Asp mutation in COL7A1 responsible for dominant dystrophic epidermolysis bullosa: More severe phenotype in female members of a Chinese family, J. Dermatol.
Sci, 49, 166-169 (2008).
Yong-bo Yuan, Shu-ming Chen, Jia-rong Lian, Ze-feng
Xie and Xiang Zhou, Improved efficiency in top-emitting
OLEDs with p-type Si anode, Proc. SPIE, 6828, 68280P/168280P/8 (2008).
Yisheng Song, Xiang Zhou and Lina Chen, Protective effect of atorvastatin on oxidative damage in endothelial precursor cells, Shaanxi Yixue Zazhi, 37, 294-295 (2008).
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