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Product Safety Summary
SUBSTANCE NAME
CYTOP® 255 organophosphine
Dicyclopentylphosphine
Phosphine, dicyclopentyl-
GENERAL STATEMENT
Dicyclopentylphosphine is spontaneously flammable in air and may cause severe skin and eye burns.
CHEMICAL IDENTITY
EC Name:
EC-No. :
CAS-No. :
REACH Registration No.:
IUPAC name:
Molecular formula:
Structural formula:
NA
NA
39864-68-1
NA
Dicyclopentylphosphine
C 10 H 19 P
USES AND APPLICATIONS
CYTOP® 255 organophosphine is used as a processing aide for a variety of common reactions used in the
pharmaceutical and fine chemical industries. It is also used as a catalyst or intermediate in chemical reactions.
PHYSICAL CHEMICAL PROPERTIES
Appearance
Odor
Melting point
Boiling point/boiling range:
Vapor pressure:
Molecular Weight:
Specific gravity:
Flash point:
Flammability:
LogPow:
clear liquid
petroleum distillate - similar to a mild turpentine smell
not applicable
150 °C @ 40 mm Hg
2mm Hg at 60 °C
170
0.937g/cc @ 25 ⁰C
>213 °C
extremely flammable (catches fire if exposed to air)
not available
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Product Safety Summary
HEALTH EFFECTS
Dicyclopentylphosphine is a pyrophoric material and overexposure by the oral and inhalation route is
unlikely. The toxicological properties of this material have not been fully investigated. Based on the EU
classification system (REGULATION (EC) No 1272/2008) dicyclopentylphosphine is classified as a pyrophoric
material, causes skin burns and eye damage. Workers should be properly instructed and supervised in the
handling of the substance. CYTOP® 255 organophosphine may contain up to 2% toluene which may cause
effects in an unborn fetus. Significant exposure to toluene is not expected because exposure to
dicyclopentylphosphine will be avoided due to the potential for skin burns anf eye damage.
EFFECT ASSESSMENT
Acute Toxicity
(oral/dermal/inhalation)
Irritation/Corrosivity
(skin/eye/respiratory tract)
Sensitization
(skin/respiratory tract)
Repeated Exposure
Mutagenicity
Carcinogenicity
Reproductive Toxicity
ENVIRONMENTAL EFFECTS
EFFECT ASSESSMENT
Aquatic Toxicity
FATE AND BEHAVIOR
Biodegradation
Bioaccumulation potential
PBT/vPvB conclusion
RESULT
Not evaluated. Based on the pyrophoric property of this material,
overexposure by the oral and inhalation route may cause burns to
the mouth, throat or respiratory tract.
Dicyclopentylphosphine causes severe skin burns and eye damage.
Dicyclopentylphosphine is not known to be a skin sensitizer.
Not evaluated. Based on available data and/or professional
judgment, the classification criteria are not met.
Not evaluated. Based on available data and/or professional
judgment, the classification criteria are not met.
Not evaluated. Based on available data and/or professional
judgment, the classification criteria are not met.
Not evaluated. Based on available data and/or professional
judgment, the classification criteria are not met.
RESULT
Dicyclopentylphosphine has not been evaluated for aquatic effects.
RESULT
Not evaluated. Based on available data and/or professional
judgment, the classification criteria are not met.
Based on professional judgment, dicyclopentylphosphine has a
low potential for bio-accumulation.
Based on professional judgment, dicyclopentylphosphine is not
considered to be persistent or bioaccumulating. This substance is
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EXPOSURE
Product Safety Summary
not considered to be very persistent nor very bioaccumulating
(vPvB).
Human Health
Dicyclopentylphosphine is used solely in industrial facilities. When the recommended risk management
measures and required operational conditions are observed, worker exposures are expected to be minimal
during the manufacture and industrial use of dicyclopentylphosphine. There is no expected consumer
exposure to dicyclopentylphosphine, including handling of finished products.
Environment
Due to physical/chemical characteristics and professional judgment dicyclopentylphosphine has a low
potential for bioaccumulation or environmental persistence. No direct release of dicyclopentylphosphine to
soil is expected during manufacturing or industrial use. If a release does occur it is important to use
appropriate risk management procedures.
RISK MANAGEMENT RECOMMENDATIONS
Dicyclopentylphosphine is classified as a pyrophoric material which causes skin burns and eye damage.
Working with this substance requires the use of appropriate chemical resistant gloves and protective
clothing. Where inhalation exposure may occur, wear an approved, full-faced respirator. Industrial workers
should receive task specific training on how to use the protective equipment. Food, beverages, and tobacco
products should not be carried, stored, or consumed where this material is in use. Before eating, drinking, or
smoking, wash face and hands thoroughly with soap and water. The most effective fire extinguishing agent is
AFFF Foam. Dry chemical powder pressurized with nitrogen, sand or carbon dioxide are effective alternative
extinguishing media, however, reignition of material is likely. Immediate action should be taken to confine the
fire. If fire cannot be controlled with an extinguishing agent, keep a safe distance, protect adjacent property
and allow the product to burn until consumed. Human exposure should be prevented and nonessential
personnel evacuated from the immediate area. Breathing vapors from this material or its combustion
products should be avoided by using proper respiratory equipment. The following are first aid measures that
should be taken if exposure should occur:
•
•
•
•
Ingestion: If swallowed, call a physician immediately. Only induce vomiting at the instruction of a
physician. Never give anything by mouth to an unconscious person.
Skin Contact: Immediately take off all contaminated clothing. Wear impermeable gloves. Wash
immediately with plenty of water and soap. Pay particular attention to skin crevices, nail folds,
etc. Do not reuse contaminated clothing without laundering. Do not reuse contaminated leather
footwear.
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes and seek immediate
medical attention.
Inhalation: Remove to fresh air. If breathing is difficult, give oxygen. Apply artificial respiration if
patient is not breathing. Obtain medical attention immediately.
ENVIRONMENTAL PRECAUTIONS
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Exposure to air and other oxidizing material must be avoided. This material is a strong reducing agent and
may react with combustible substances creating a fire or explosion hazard. Store dicyclopentylphosphine
under an inert atmosphere such as nitrogen or carbon dioxide. Avoid contact with oxidizing agents,
chlorocarbons, and bromocarbons. Block off source of spill, extinguish fire with appropriate extinguishing
agent. Do not contact spill with paper cloth or vermiculite as spontaneous ignition will occur. Cover spill with
an inert absorbent clay (such as cat litter or similar material) and place in a sealable container, sized such that
free air volume is minimized. Seal under inert gas. Dispose of contents/container in accordance with local and
national regulations.
GOVERNMENT AGENCY REVIEW
Dicyclopentylphosphine is not listed on a Chemical Inventories for any country.
REGULATORY INFORMATION/CLASSIFICATION AND LABELING
Classification of the substance according to REGULATION (EC) No 1272/2008:
R17 - Spontaneously flammable in air.
R34 - Causes burns.
R41 - Risk of serious damage to eyes.
CONCLUSION
Dicyclopentylphosphine is used as a catalyst or intermediate in chemical reactions and as a processing aide
for a variety of common reactions used in the pharmaceutical and fine chemical industries. Before using this
material, all workers should review the Material Safety Data Sheet and receive training on safety and handling
procedures, and recommended personal protective equipment. Considering these precautions, the potential
level of exposure to dicyclopentylphosphine, in normal use, is considered to be very low.
CONTACT INFORMATION WITHIN COMPANY
For further information on this substance or product safety summaries in general, please contact:
Company:
Address:
Town/Country Postal code:
E-mail:
Worldwide Contact Info:
Cytec Industries
5 Garret Mountain Plaza
Woodland Park, NJ 07424 (USA)
[email protected]
www.cytec.com
GLOSSARY
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Acute toxicity
Biodegradation
Bioaccumulation
Carcinogenicity
Chronic toxicity
Flash point
Genotoxicity
Hydrolyze
Mutagenicity
PBT
Persistence
Reprotoxicity
Sensitizing
Sediment
Vapor pressure
vPvB
DATE OF ISSUE
Harmful effect resulting from a single or short
term exposure to a substance.
Decomposition or breakdown of a substance under
natural conditions (actions of micro organisms
etc).
Progressive accumulation in living organisms of a
chemical substance present in the environment.
Substance effects causing cancer.
Harmful effect after repeated exposures or long
term exposure to a substance.
The lowest temperature at which vapor of the
substance may form an ignitable mixture with air.
Substance effect that causes damage to genes,
including mutagenicity and clastogenicity.
Undergo hydrolysis; decompose by reacting with
water.
Substance effect that cause mutation on genes.
Persistent, bioaccumulative, toxic chemical.
Refers to the length of time a compound stays in
the environment, once introduced.
Including teratogenicity, embryotoxicity and
harmful effects on fertility.
Allergenic.
Topsoil, sand and minerals washed from land into
water forming in the end a layer at the bottom of
rivers and sea.
A measure of a substance’s property to evaporate.
Very persistent, very bioaccumulative.
September 2012
REVISION
Version 1.0
ADDITIONAL INFORMATION
Further information can be found in the MSDS.
DISCLAIMER
The information contained in this paper is intended as advice only and whilst the information is provided in
utmost good faith and has been based on the best information currently available, is to be relied upon at the
user’s own risk. No representations or warranties are made with regards to its completeness or accuracy and
no liability will be accepted by Cytec Industries for damages of any nature whatsoever resulting from the use
of or reliance on the information.
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