Proportionality factor
of the e↵ect sizes (⌘)
-1
-0.7
-0.5
-0.3
-0.2
-0.1
0
0.1
0.2
0.3
0.5
0.7
1
Absolute fold change
of the e↵ect sizes
1
1.43
2
3.33
5
10
inf
10
5
3.33
2
1.43
1
Absolute fold change
of the variance explained
1
2.04
4
11.11
25
100
inf
100
25
11.11
4
2.04
1
Relative direction
of the genetic signals
opposite
opposite
opposite
opposite
opposite
opposite
N/A
same
same
same
same
same
same
Supplementary Table 3 Relationship between the proportionality factor of the e↵ect sizes
used in simulations, fold change and relative direction of genetic e↵ects across contexts.
Shown is the relationship between the proportionality factor of the e↵ect sizes in the two simulated
contexts (⌘, x-axis in Fig. 2c), the corresponding fold change of the e↵ect sizes, the fold change of the
variance explained by the region and the relative directionality of the genetic signals. For 1 < ⌘ < 1,
the absolute fold change increases for small absolute values of ⌘ and tends to infinity in the limit ⌘ ! 0.
The range ⌘ < 0 corresponds to genetic e↵ect with opposite e↵ects. The setting ⌘ = 0 corresponds to
a local genetic e↵ect that is specific to one context (no e↵ect in the second context). Finally, ⌘ = 1
corresponds to no interaction (the fold change is zero and the direction of genetic e↵ects is the same).
Supplementary Table 4 Tabular summary of results from the monocyte gene expression analyses. The results table is provided as separate supplementary information file:
supp table 4 stimulus eQTL.xlsx
4