Webinar: Making Trials Work Harder
2 December 2015 at 12:00
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Webinar: Making Trials Work Harder
2 December 2015 at 12:00
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Meeting Information:
Chaired by Jo Rick and Peter Bower
Presentation followed by a discussion session
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Please note this webinar will be recorded
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How do we make the gains outweigh the
pain?
Part 1:
* What are embedded methodology trials & why do we need
them?
* ‘Here’s one we made earlier …’ Examples from York CTU and
the Healthlines studies
Questions?
Part 2:
* What have we learnt about doing embedded methodology
trials? – our experiences, findings from the SWANS study
* What support and resources are out there?
Questions and discussion
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* Testing RCT methodology
* One aspect of an RCT manipulated to test the impact of on
trial performance
* Examples include:
* Randomising participants to different methods of recruitment
* Randomising trial participants to different processes such as ways
of participating, format of reminders, use of incentives
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Aims:
* Usually to improve trial recruitment and/or retention
* Other aims include:
* Widening participation
* Accessing hard to reach groups
* Improving informed quality of consent
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Actual recruitment
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Target recruitment
* Trial recruitment can be
challenging
* Trials can fail to meet
recruitment targets for all
kinds of reasons
* Very little evidence about
effective recruitment
strategies in general…
* … 45 recruitment trials
identified
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* Retention can be equally
challenging…
* …and suffers from the
same lack of evidence
about effective methods
as recruitment –
currently 38 retention
trials
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* Healthlines - two linked trials of telehealth in depression
(Healthlines Depression) or cardiovascular risk (Healthlines CVD).
* The standard PIS optimised (see handout)
* Improved readability
* Improved navigation
* Participants randomised to receive either the standard or the
optimised PIS
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* Depression: 6.3 % (optimised) randomised, 4.0 % (standard)
* 4% recruitment = 15,000 invitations to recruit 600
6% recruitment = 10,000 invitations to recruit 600
* CVD: – no effect
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Moving from
* ‘Cottage industry’
* Individual studies
* One off interventions
Moving to
* Beyond individual studies
* Standardised interventions
* Repeated tests across
multiple trials
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To get involved in the discussion:
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• Activate the Participants panel by
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• If your discussion/question is
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* Embedded trial methodology:
* It is feasible (10 trials complete or in progress for
START)
* A number of barriers to implementing embedded
trial methodology
* SWANS is a Hub funded exploration of the
barriers and facilitators to the wider adoption
of embedded trials as a way of promoting
evidence based trials
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* Barriers & facilitators to embedded trials
Ideas to
test
Trial
development
Peer review
& ethics
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*Ideas to
test
“Where should
efforts be
concentrated?”
“We need coordination?”
“What is it
worth testing?”
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* TrialForge IQuaD initiative
* Retention intervention
* Promising results from one study
* No/low cost
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* Potential motivators
* Skill development
* Publications
* Lead authorship
* Any others…?
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To get involved in the discussion:
•
•
Either, if you have an audio connection
• Activate the Participants panel by
clicking here
• Alert the chair by clicking the
‘raise hand’ icon
• If you are selected, the chair will
unmute your microphone and
invite you to ask your question.
Or, if you do not have an audio
connection
• Please type a brief text in the
Chat panel
• Select ‘Host & Presenter’ from the
‘Send to’ drop-down menu
• If your discussion/question is
selected, the chair will read it out
on your behalf.
* Thinking about a trial you work on, what would be your
concerns about running an embedded methodology trial?
* What resources or types of support would help?
* why that type of support?;
* how should it be delivered?;
* by whom?/At what stage?
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* [email protected]
* [email protected]
* http://www.qub.ac.uk/sites/TheNorthernIrelandNetworkfor
TrialsMethodologyResearch/SWATSWARInformation/Repositor
ies/SWATStore/www.trialforge.org
* www.trialforge.org
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To get involved in the discussion:
•
•
Either, if you have an audio connection
• Activate the Participants panel by
clicking here
• Alert the chair by clicking the
‘raise hand’ icon
• If you are selected, the chair will
unmute your microphone and
invite you to ask your question.
Or, if you do not have an audio
connection
• Please type a brief text in the
Chat panel
• Select ‘Host & Presenter’ from the
‘Send to’ drop-down menu
• If your discussion/question is
selected, the chair will read it out
on your behalf.
* Thinking about a trial you work on, what would be your
concerns about running an embedded methodology trial?
* What resources or types of support would help?
* why that type of support?;
* how should it be delivered?;
* by whom?/At what stage?
*
* [email protected]
* [email protected]
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