OCCI Lecture
Speaker:
Dr. Mark Sumarah, Research Scientist,
Agriculture and Agri-Food Canada, London,
Ontario
Title:
Application of Analytical and Natural
Products Chemistry to Canadian Agricultural
Problems
Date, Time and Place: Friday, March 24, 2017, 10 am, TB 342
Fungi play important roles from both negative and positive perspectives in Canadian agriculture.
Pathogenic or bad fungi infect crops in the field or during storage; these fungi are capable of
producing secondary metabolites (mycotoxins) that can cause harm to humans and/or animals.
Beneficial fungal endophytes or good fungi form symbiotic relationships with plants and play an
important role in the defense of the host plant against pathogen and insect pests. The first part of
this talk will focus on the development and application of new non-targeted LC-MS/MS methods
using data independent acquisition (DIA) for the detection of emerging mycotoxins. The second
part will focus on a LC-MS/MS based metabolomics driven natural products discovery study of
secondary metabolites produced by endophytic fungi from fruit bearing plants.
Selected Publications:
Renaud JB, Sabourin L, Topp E, Sumarah MW (2017) A spectral counting approach to measure
selectivity of high resolution LC-MS methods for environmental analysis. Analytical Chemistry
89: 2747–2754.
Burgess KMN, Renaud JB, McDowell T, Sumarah MW (2016) Mechanistic Insight into the
Biosynthesis and Detoxification of Fumonisin Mycotoxins. ACS Chemical Biology 11: 26182625.
Renaud JB, Sumarah MW (2016) Data independent acquisition-digital archiving mass
spectrometry: application to single kernel mycotoxin analysis of Fusarium graminearum infected
maize. Analytical and Bioanalytical Chemistry 408: 3083–3091.