Glycoproducts for life sciences
Engineering and production
OligoTech
®
Key to catalog reading
1
2
GLY022
Lacto-N-neohexaose
LNnH
7
C40H68N2O31
FW 1072
GalE-4GlcNAcE-3GalE-4GlcNAcE-GalE-4Glc
3
[64003-52-7]
4
OH
OH
OH
O
5
HO
AcNH
HO
O
OH
OH
O
O
AcNH
HO
O
OH
O
OH
O
OH
Human Milk Oligosaccharide
Kunz et al., 2000. Ann Rev Nutr. 20, 699-722
6
O
OH
OH
9
OH
OH
O
O
HO
O
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
1
Product Code
5
Structure
7
Formula
2
Product Name
6
Reference
8
Formula Weight
3
Synonym or Acronym
9
Cas Number
4
Text Formula
10
Typical pack size
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INTERIEUR Catalogue OligoTech 2012.pdf 1
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10
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Glycoproducts for life sciences
Engineering and production
Table of contents
x
x
x
x
x
x
Key to catalogue reading
About OligoTech® - Catalogue, customized delivery and services
Products
Product Code Index
Product Name Index
Sale Terms and conditions
3
6
11
162
165
175
Products
x
4
Natural polysaccharides and oligosaccharides extracted from biomass
Glucan
13
Xanthan
Chitin / Chitosan
Ulvan
Fucoidan / Galactofucan
Xylan
Galactan
33
35
41
45
49
53
Mannan
59
Alginate
Galacturonan / Apiogalacturonan
Arabinan
Fructan
Spirulan
Heteroglycan
69
75
79
81
85
87
Xyloglucan
Cellodextrin / Maltodextrin
Laminaran
Lichenan / Isolichenan
Scleroglucan
Lentinan
Pustulan
Arabinogalactan
Carrageenan
Agar
Mannan
Xylomannan
Galactomannan
Glucomannan
Galactoglucomannan
Inulin
11
14
20
26
28
30
31
32
33
35
41
45
49
54
56
58
60
62
63
66
68
69
75
79
82
85
87
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Glycoproducts for life sciences
Engineering and production
x
Glycan oligosaccharides
89
Core structures
93
Blood groups and Lewis antigens
96
Fucosylated oligosaccharides
1099
Galα--3 oligosaccharides
1112
Sialylated oligosaccharides
1155
Ganglioside sugars (Ganglio--Series)
Globo--series (P antigens)
1188
1233
Glucuronylated oligosaccharides
Miscellaneous
1288
1299
Type 1
Type 4
Type 2
H (O )antigens
A antigens
B antigens
Lewis antigens
Lacto-series
3 Fucosyllactose core oligosaccharides
Galili and xeno antigens
Isoglobo-series
Type 1
Type 2
P blood group antigens and analogues
Globo-series
Stage-Specific Embryonic antigens
Forssman antigens
Trehalose-like sugars
Blood-group-related antigens
Globo-series analogues
IsoGlobo-series analogues
Ganglio-series antigens analogues
93
94
94
97
99
102
105
109
110
112
114
115
116
118
124
125
126
127
128
129
130
130
133
136
x
Monosaccharides, di-, tri, tetrasaccharides
137
x
GlycoBricks®: Functionalized Glycans
141
x
Glycosaminoglycans
151
Heparosan & Derived
Oligosaccharides
x
x
1522
Heparosan K5 polysaccharide
Heparosan-Derived oligosaccharides
152
153
Aminoglycoside derivatives
Human & Bacterial Lectins
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157
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Glycoproducts for life sciences
Engineering and production
About OligoTech®
Catalogue, customized delivery and services
Mission
Elicityl is a biotech company specialized in carbohydrate engineering and production that
offers a wide and unique collection of glycoproducts for research, development and for industrial
applications.
Elicityl provides a wide range of products and services for the rapidly growing field of research
and innovation in glycosciences through the OligoTech®.
Elicityl is customer-oriented and we evaluate all specific demand to accompany your project.
We use the appropriate methodologies of purification, characterization and quality control to
guarantee that our products meet customer needs.
Our original technology of production allows getting available specific carbohydrates in large
quantities at competitive cost.
OligoTech®: Glycoproducts for life sciences
The OligoTech® catalogue includes over 400 products for glycosciences and in particular for
biomedical, phytopharmaceutical, cosmetics and nutraceutics R&D.
x
Natural polysaccharides and oligosaccharides extracted from biomass
x
Glycan oligosaccharides
x
Monosaccharides, di-, tri-, tetrasaccharides
x
Glycobricks®: Functionalized Glycans
x
Glycosaminoglycans
x
Aminoglycoside derivatives
x
Lectins
Bulk quantities are available on specific demand.
6
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Glycoproducts for life sciences
Engineering and production
OligoTech ®
Catalogue, customized delivery and services
The OligoTech® offer
Catalogue
x Unique offer of Glycoproducts
x Reagents for research
x Order on-line –NEW-
Customized delivery
x
x
x
x
x
x
x
x
Feasibility study
Customized production
Production from the g, 100 g and multi kg scale
For development and/or production of specific needs
Targeted selections of carbohydrates for screening
Affinity adsorbents
Immobilizable oligosaccharides for spotting
Glycan array
Analysis services
x
x
x
x
Natural carbohydrate characterization & identification
Purification of samples for analysis
Structure, monomer composition, sulfation…
Purity determination
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Glycoproducts for life sciences
Engineering and production
OligoTech ®
Catalogue, customized delivery and services
OligoTech® know-how & capabilities
x
Elicityl supplies carbohydrates and glycoproducts manufactured in our facilities by
extraction, enzymatic processes and fermentation.
x
Elicityl develops industrial methods of production based on its expertise in carbohydrate
elaboration, purification and characterization.
Analysis and quality control
x
Elicityl develops standardized production processes
reproducibility and traceability of production batches.
in
a
QA/QC
policy
allowing
x
The products supplied are consistent with internal standards. They are analysed by
adapted and efficient technologies such as HPLC, HPAEC, NMR, Mass spectrometry or SEC.
x
Production traceability is guaranteed by individual production dossier for each Product.
x
Storage of reference samples at Elicityl for each batch of production.
x
Production processes are consistent with ISO9001 procedures.
Each product is supplied with its Certificate of Analysis.
8
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Glycoproducts for life sciences
Engineering and production
OligoTech ®
Catalogue, customized delivery and services
Elicityl distinctive points
x
Process know-how, development and production lines fully owned by Elicityl.
x
Exclusive license agreements for the exploitation of innovative technologies for large scale
oligosaccharide production.
x
Products available in large quantities.
x
Cooperative expertise network and partnerships for biological activity screening programs.
x
Selections of carbohydrates available in large quantities:
ÆHuman milk oligosaccharides (HMOs)
ÆTumor-associated carbohydrate antigens (TACAs)
ÆHisto-blood group antigens (ABH, Lewis and P systems)
ÆCosmetic applications following INCI
x
Flexibility
x
Confidentiality
Distribution
Elicityl’s OligoTech® is distributed in Japan by Ikeda Scientific (www.ikedarika.co.jp).
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OligoTech®
Natural Polysaccharides & Oligosaccharides
Extraction from Biomass
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OligoTech®
12
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www.e
licityl-oligo
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ontact@e
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OligoTech®
Glucan
Extraction from biomass
Xyloglucan
Cellodextrin / Maltodextrin
Laminaran
Lichenan / Isolichenan
Scleroglucan
Lentinan
Pustulan
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OligoTech®
Glucan
Xyloglucan
Extraction from biomass
STRUCTURAL DESCRIPTION
Xyloglucans are hemicellulosic polysaccharides present in the primary cell walls of all types of
higher plants.
Xyloglucans consist of a β-D-(1-4) glucan backbone with α-D-xylosyl residues attached to the
6-position of approximatively 75% of the glucosyl residues of the backbone. Some of the α-Dxylosyl residues are themselves substituted at the 2-position with E-galactosyl or α(1-2)
Fucosyl-β(1-2) galactosyl moieties.
Æ Xyloglucan oligosaccharides nomenclature according Fry et al. Plant Physiol. 1993 103:1-5.
β-D-Glc
α-D-Xyl
1
↓
6
β-D-Glc
β-D-Gal
1
↓
2
α-D-Xyl
1
↓
6
β-D-Glc
α-L-Fuc
1
↓
2
β-D-Gal
1
↓
2
α-D-Xyl
1
↓
6
β-D-Glc
α-L-Gal
1
↓
2
β-D-Gal
1
↓
2
α-D-Xyl
1
↓
6
β-D-Glc
α-L-Ara
1
↓
2
α-D-Xyl
1
↓
6
β-D-Glc
β-L-Ara
1
↓
2
α-L-Ara
1
↓
2
α-D-Xyl
1
↓
6
β-D-Glc
G
X
L
F
J
S
T
α-D-Xyl
1
↓
6
β-D-Glc
2
↑
1
α-L-Ara
α-D-Xyl
1
↓
6
β-D-Glc
2
↑
1
β-D-Xyl
α-D-Xyl
1
↓
6
β-D-Glc
2
↑
1
β-D-Xyl
3
↑
1
α-L-Ara
A
B
C
D-Glcol
Gol
POSSIBLE BIOMASS SOURCE(S)
Apple
Tamarind
Bilberry
Olive fruit…
ACTIVITIES AND USES
Xyloglucan is a source of biologically active oligosaccharides and polysaccharides. They
have been shown to control plant development and metabolism. Oligosaccharides issued from
apple and tamarind are considered as biofertilizers and elicitors of plant defences (Elicityl
Patents).
Additionally, Xyloglucans were indicated to possess immunomodulatory activity (Rosário
MM et al., Phytochemistry. 2008 Jan; 69(2):464-72) and are also likely to be used as
immunoprotective ingredients in sun creams.
Æ Recommended paper:
A. Lama-Muñoz et al. Food Hydrocolloids 28 (2012) 92-104
14
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OligoTech®
Glucan
Xyloglucan
Extraction from biomass
This group of fucosylated Xyloglucan oligosaccharides is produced by enzymatic engineering and is
extracted from apple. Each product is purified by semi-preparative HPLC.
GLU1000
Xyloglucan oligosaccharides
100% xyloglucan oligosaccharides extracted and purified from apple.
Obtained through enzymatic clivage and Solid Phase Extraction
Chromatography.
100 mg, 1 g, 10 g
GLU1110
XFG xyloglucan oligosaccharide (DP7)
100% xyloglucan oligosaccharides containing almost 80% of
XFG. Reducing end.
C40H68O33
FW 1076.94
α-L-Fuc
1
↓
2
β-D-Gal
1
↓
2
α-D-Xyl
α-D-Xyl
1
1
↓
↓
6
6
β-D-Glc1→4β-D-Glc1→4β-D-Glc
X
F
G
Product provided for the following study : Audfray et al., 2012. Fucose-binding Lectin
from Opportunistic Pathogen Burkholderia ambifaria binds to both Plant and Human
Oligosaccharidic Epitopes. Journal of Biol. Chem, vol 287. N°6.
GLU1111
10 mg, 100 mg, 1 g
Reduced XFG xyloglucan oligosaccharide (DP7)
XFGol
100% xyloglucan oligosaccharides containing almost 80% of
reduced XFG (XFGol).
α-L-Fuc
1
↓
2
β-D-Gal
1
↓
2
α-D-Xyl
α-D-Xyl
1
1
↓
↓
6
6
β-D-Glc1→4β-D-Glc1→4β-D-Gol
X
F
C40H70O33
FW 1078.95
[870721-81-6]
Gol
10 mg, 100 mg, 1 g
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OligoTech®
GLU1112
Acetylated XFG xyloglucan oligosaccharide (DP7)
XFG(Ac)
100% xyloglucan oligosaccharides containing almost 80% of
mono-acetylated and non-reduced XFG or XFG(Ac).
Mono acetylation
y
occurs on the galactosyl residue.
C42H70O34
FW 1118.98
10 mg, 100 mg, 1 g
GLU1160
XLFG xyloglucan oligosaccharide (DP10)
100% xyloglucan oligosaccharides containing almost 60% of
XLFG. Reducing
g end.
C57H96O47
FW 1533.33
10 mg, 100 mg, 1 g
GLU1161
Reduced XLFG xyloglucan oligosaccharide (DP10)
XLFGol
100% xyloglucan oligosaccharides containing almost 75% of
reduced XLFG or XLFGol.
C57H98O47
FW 1535.35
10 mg, 100 mg, 1 g
16
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OligoTech®
GLU1162
Acetylated XLFG xyloglucan oligosaccharide (DP10)
XLFG(Ac)
100% xyloglucan oligosaccharides containing almost 60% of
mono-acetylated and non-reduced XLFG or XLFG(Ac).
C59H98O48
FW 1575.37
10 mg, 100 mg, 1 g
GLU1180
XLLFG xyloglucan oligosaccharide (DP13)
100% xyloglucan oligosaccharides containing almost 55% of
non-reduced XLLFG.
C74H124O61
FW 1989.72
10 mg, 100 mg, 1 g
GLU1181
Reduced XLLFG xyloglucan oligosaccharide (DP13)
XLLFGol
100% xyloglucan oligosaccharides containing almost 55% of
reduced XLLFG or XLLFGol.
C74H126O61
FW 1991.74
10 mg, 100 mg, 1 g
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OligoTech®
GLU1182
Acetylated XLLFG xyloglucan oligosaccharide (DP13)
XLLFG(Ac)
100% xyloglucan oligosaccharides containing almost 55% of nonreduced and mono-acetylated XLLFG or XLLFGol(Ac).
C76H126O62
FW 2031.76
10 mg, 100 mg, 1 g
Other Xyloglucan oligosaccharides available upon request
Product Code
Product Name
GLU1100
XLG
oligosaccharide
GLU1101
Acetylated XLG
oligosaccharide
GLU1120
XXLG
oligosaccharide
GLU1121
Reduced XXLG
oligosaccharide
(XXLGol)
Reduced form of XXLG
with terminal glucitol
Degree of polymerization
DP8
C45H78O38
FW 1227.07
GLU1122
Acetylated XXLG
oligosaccharide
(XXLG(Ac))
Mono-acetylated form of XXLG
oligosaccharide
Degree of polymerization
DP8
C47H78O39
FW 1267.09
GLU1130
LFG
oligosaccharide
18
Structure
Degree of polymerization
DP 6
C34H58O29
FW 930.80
Mono-acetylated form of XLG
oligosaccharide
Degree of polymerization
DP6
C36H60O30
FW 972.84
Degree of polymerization
DP8
C45H76O38
FW 1225.05
Degree of polymerization
DP8
C46H78O38
FW 1239.08
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OligoTech®
Product
Code
Product Name
GLU1131
Reduced LFG
oligosaccharide
GLU1140
XLLG
oligosaccharide
GLU1141
Reduced XLLG
oligosaccharide
(XLLGol)
Reduced form of XLLG
with terminal glucitol
Degree of polymerization
DP 9
C51H88O43
FW 1389.21
GLU1142
Acetylated XLLG
oligosaccharide
(XLLG(Ac))
Mono-acetylated form of XLLG
Degree of polymerization
DP 9
C53H88O44
FW 1429.23
GLU1150
XXFG
oligosaccharide
GLU1151
Reduced XXFG
oligosaccharide
(XXFGol)
Reduced form of XXFG
with terminal glucitol
Degree of polymerization
DP 9
C51H88O43
FW 1373.21
GLU1152
Acetylated XXFG
oligosaccharide
(XLLG(Ac))
Mono-acetylated form of XXFG
Degree of polymerization
DP 9
C53H88O43
FW 1413.23
GLU1170
XLFGG
oligosaccharide
GLU1171
Reduced XLFGG
oligosaccharide
(XXLGol)
Structure
Reduced form of LFG
with terminal glucitol
Degree of polymerization
DP8
C46H80O38
FW 1241.09
Degree of polymerization
DP 9
C51H86O43
FW 1387.19
Degree of polymerization
DP 9
C51H86O42
FW 1371.19
Degree of polymerization
DP11
C63H106O52
FW 1695.47
Reduced form of XLFGG
with terminal glucitol
Degree of polymerization
DP11
C63H108O52
FW 1697.49
Available prepacks 10 mg, 100 mg, 1 g on request
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OligoTech®
Glucan
Extraction from biomass
Cellodextrin / Maltodextrin
STRUCTURAL DESCRIPTION
Cellodextrins are glucose polymers of two or more glucose monomers resulting from the
breakdown of cellulose (from cotton linters as raw material).
Cellodextrins consist of repeating β(1-4) linked D-glucose monomers. The most common
cellodextrins are:
x cellobiose (DP=2)
x cellotriaose (DP=3)
x cellotetraose (DP=4)
x cellopentaose (DP=5)
x cellohexaose (DP=6)
The degree of polymerization (DP) indicates the number of linked glucose monomers it
contains.
Maltodextrins are a group of low-molecular-weight sugar produced by the hydrolysis of
starch. Maltodextrins are a linear α(1-4) linked D-glucose polymer.
Industrial production is, in general, performed by acidic hydrolysis of potato starch.
ACTIVITIES AND USES
Cellodextrins are found a wide range of applications in functional food (probiotic benefits),
pharmaceutical and chemical industries as well as agriculture and environmental engineering.
Maltodextrins are used as:
x
x
x
crispness enhancer for food processing, in food batters, coatings and glazes, (E number
1400),
textile finishing agent to increase weight and stiffness of textile fabrics,
thickening and binding agent in pharmaceuticals and paper coatings.
Widely used as Analytical and Chromatographic tools enabling SEC calibration.
20
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OligoTech®
Glucan
Cellodextrin
Extraction from biomass
GLU300
Cellobiose
β(1-4) linked D-glucose
Degree of polymerization (DP): 2.
O
O
HO
O
OH
10 mg, 100 mg
OH
OH
GLU301
[528-50-7]
OH
OH
HO
HO
C12H22O11
FW 342.29
Cellotriose
β(1-4) linked D-glucose
Degree of polymerization (DP): 3.
C18H32O16
FW 504.43
[33404-34-1]
OH
O
HO
HO
HO
O
O
OH
GLU302
OH
OH
O
O
HO
OH
10 mg, 100 mg
OH
OH
Cellotetraose
β(1-4) linked D-glucose
Degree of polymerization (DP): 4.
C24H42O21
FW 666.57
[38819-01-1]
OH
OH
HO
HO
O
O
O
HO
HO
O
O
O
HO
O
OH
OH
OH
OH
OH
OH
OH
10 mg, 100 mg
GLU303
Cellopentaose
β(1-4) linked D-glucose
Degree of polymerization (DP): 5.
C30H52O26
FW 828.71
[2240-27-9]
OH
HO
O
O
OH
OH
OH
HO
O
O
OH
O
HO
O
OH
OH
2
10 mg, 100 mg
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OligoTech®
GLU304
Cellohexaose
β(1-4) linked D-glucose
Degree of polymerization (DP): 6.
O
O
HO
O
OH
OH
OH
GLU305
[2478-35-5]
OH
OH
HO
O
C36H62O31
FW 990.85
3
10 mg, 100 mg
Celloheptaose
β(1-4) linked D-glucose
Degree of polymerization (DP): 7.
OH
HO
O
O
HO
O
[52646-27-2]
OH
OH
O
O
HO
O
OH
GLU306
C42H72O36
FW 1152.99
OH
OH
OH
3
5 mg, 10 mg, 100 mg
Cellooctaose
β(1-4) linked D-glucose
Degree of polymerization (DP): 8.
OH
OH
HO
O
O
O
HO
OH
GLU308
C48H82O41
FW 1315.13
O
OH
OH
4
5 mg, 10 mg
High DP Cello-Oligosaccharides
β(1-4) linked D-glucose oligomers Mixture
containing 20% DP9 & 40% DP8 (HPAEC analysis)
5 mg, 10 mg
GLU309
Cello-Oligosaccharides Kit
Individually packaged Cello-oligosaccharide kit from
Cellobiose (DP2) to Celloheptaose (DP7).
NEW
22
Each proposed in first coming pack size
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OligoTech®
Glucan
Maltodextrin
Extraction from biomass
GLU310
Maltodextrin High DP oligosaccharide mixture
α(1-4) linked D-glucose / α(1-6) branching
Observed Degree of polymerization (DP): 10 to 40.
α(1-6) branching degree determined by 1H NMR
100 mg, 1 g, 10 g
GLU311
Maltodextrin oligosaccharide mixture
α(1-4) linked D-glucose / traces of α(1-6) branching
Observed Degree of polymerization (DP): 2 to 15.
α(1-6) branching degree determined by 1H NMR
100 mg, 1 g, 10 g
GLU312
Maltose
α(1-4) linked D-glucose
Degree of polymerization (DP): 2.
C12H22O11
FW 342.29
[6363-53-7]
OH
O
HO
HO
OH
OH
O
O
HO
OH
GLU313
100 mg, 1 g, 10 g
OH
Maltotriose
α(1-4) linked D-glucose
Degree of polymerization (DP): 3.
C18H32O16
FW 504.43
[1109-28-0]
OH
O
HO
HO
OH
OH
O
O
HO
OH
OH
O
O
HO
OH
GLU314
OH
100 mg, 1 g, 10 g
Maltotetraose
α(1-4) linked D-glucose
Degree of polymerization (DP): 4.
C24H42O21
FW 666.57
[34612-38-9]
OH
HO
HO
O
OH
OH
O
O
OH
HO
OH
O
O
HO
n=2
OH
OH
100 mg, 1 g, 10 g
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OligoTech®
GLU315
Maltopentaose
α(1-4) linked D-glucose / traces of α(1-6) branching
Degree of polymerization (DP): 5.
C30H52O26
FW 828.71
[34620-76-3]
OH
O
HO
HO
OH
OH
O
O
OH
HO
OH
O
O
HO
n=3
GLU316
OH
OH
100 mg, 1 g
Maltohexaose
α(1-4) linked D-glucose / traces of α(1-6) branching
Degree of polymerization (DP): 6.
C36H62O31
FW 990.85
[34620-77-4]
OH
O
HO
HO
OH
OH
O
O
OH
HO
OH
O
O
HO
OH
n=4
OH
100 mg, 1 g
GLU317
Maltoheptaose
α(1-4) linked D-glucose / traces of α(1-6) branching
Degree of polymerization (DP): 7.
C42H72O36
FW 1152.99
[34620-78-5]
OH
O
HO
HO
OH
OH
O
O
OH
HO
OH
O
O
HO
OH
n=5
GLU318
OH
100 mg, 1 g
Maltooctaose
α(1-4) linked D-glucose / traces of α(1-6) branching
Degree of polymerization (DP): 8.
C48H82O41
FW 1315.13
[6156-84-9]
OH
HO
HO
O
OH
OH
O
O
OH
HO
OH
O
O
HO
n=6
OH
OH
100 mg, 1 g
24
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OligoTech®
GLU319
Maltononaose
α(1-4) linked D-glucose / traces of α(1-6) branching
Degree of polymerization (DP): 9.
C54H92O46
FW 1477.27
[6471-60-9]
OH
O
HO
HO
OH
OH
O
O
OH
HO
OH
O
O
HO
OH
n=7
GLU320
OH
10 mg, 100 mg, 1 g
Maltodecaose
α(1-4) linked D-glucose / traces of α(1-6) branching
Degree of polymerization (DP): 10.
C60H102O51
FW 1639.41
[37331-89-8]
OH
O
HO
HO
OH
OH
O
O
OH
HO
OH
O
O
HO
OH
n=8
GLU322
OH
10 mg, 100 mg, 1 g
Malto-Oligosaccharides Kit
Individually packaged Malto-oligosaccharide kit from
Maltose (DP2) to Maltodecaose (DP10).
NEW
Each proposed in first coming pack size
GLU330
Starch
α(1-4) linked D-glucose / traces of α(1-6) branching
estimated by 1H NMR.
[9005-25-8]
OH
O
HO
HO
OH
O
O
HO
O
OH
OH
O
O
OH
HO
OH
O
O
HO
n
OH
OH
On request
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OligoTech®
Glucan
Laminaran
Extraction from biomass
STRUCTURAL DESCRIPTION
Laminaran (or laminarin) is a storage polysaccharide of Laminaria sp and other brown algae
such as Fucus vesiculosus, Saccharina longicruris and Ascophyllum nodosum. It is a linear
polysaccharide made up of β(1-3) glucan with some β(1-6) branch point.
The majority of laminarans contain polymeric chains of two types: one type is built only of Glcp
residues (G-chains), whereas the other type is terminated with 1-O-substituted D-mannitol
residues (M-chains).
EXAMPLES OF BIOMASS SOURCES
Laminaria digitata
Ascophyllum nodosum
ACTIVITIES AND USES
Laminaran is claimed to modulate immune responses in mammals. Sulfated laminaran has
been shown to have heparin-like properties and to be an elicitor of plant defense reactions
against viral infections. Laminaran also has dietary fiber properties.
Æ Recommended paper(s) : Rioux et al. / Phytochemistry 70 (2009) 1069–1075).
26
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OligoTech®
Glucan
Laminaran
Extraction from biomass
GLU500
Laminaran polysaccharide from Laminaria sp.
β(1-3) linked D-glucose extracted and purified from
Laminaria sp.
OH
O
OH
GLU510
OH
OH
O
O
HO
[9008-22-4]
O
HO
HO
O
O
OH
OH
n
100 mg, 1 g
Laminaran polysaccharide from Fucus v.
β(1-3) linked D-glucose extracted and purified from
Fucus vesiculosus
[9008-22-4]
100 mg, 1 g
GLU501
Laminaran oligosaccharide mixture (<10 kDa cut-off)
β(1-3) linked D-glucose oligosaccharides prepared and
purified from Laminaria sp. D-glucan polysaccharide
by 10 kDa cut-off Ultrafiltration
10 mg, 100 mg
Please contact us for custom Laminari-oligosaccharide length tailored to your need
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OligoTech®
Glucan
Lichenan / Isolichenan
Extraction from biomass
STRUCTURAL DESCRIPTION
Lichenan (lichenin) is a linear polysaccharide isolated from lichen (ex Cetraria islandica,
Evernia prunastri). It is a homologous (1-3) and (1-4) β-D-glucan. Lichenan structure is
similar to that of barley and oat β-D-glucan; but the proportion of 1-4 to 1-3 linkage is higher
(approximately 2:1).
OH
OH
O
HO
OH
O
O
HO
O
HO
O
O
HO
O
OH
OH
OH
O
OH
O
n
OH
Isolichenan (isolichenin), a cold-water-soluble linear (1-3) and (1-4) α-glucan, with different
linkage groups among diverse taxa of lichens.
OH
OH
OH
O
O
O
OH
HO
HO
O
O
OH
O
O
HO
HO
OH
O
OH
OH
n
EXAMPLES OF BIOMASS SOURCES
Cetraria islandica
Evernia prunastri
ACTIVITIES AND USES
Recent data showed that lichenan exhibits potential anticancer and antiviral properties.
Lichenan was also found to be a serious candidate for plant health product use (Stübler et al.,
1996. Journal of Phytopathology, 144, no1;. 37-43).
Æ Recommended paper : Freysdottir et al., 2008. Internat. Immunopharmacol., 8, 423–430.
28
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OligoTech®
Glucan
Lichenan / Isolichenan
Extraction from biomass
GLU600
Lichenan polysaccharide
(1-3) and (1-4) β-D-glucan
OH
OH
O
HO
[1402-10-4]
OH
O
O
HO
O
HO
O
O
OH
OH
OH
O
O
HO
O
OH
n
OH
1 g, 10 g
GLU601
Isolichenan polysaccharide
(1-3) and (1-4) α–D-glucan
[53025-03-9]
OH
OH
HO
OH
O
O
O
OH
HO
O
OH
O
HO
OH
O
HO
OH
O
O
OH
n
100 mg, 1 g, 10 g
GLU602
Lichenan & Isolichenan polysaccharide Native grade
(1-3) and (1-4) β-D-glucan, (1-3) and (1-4) α-D-glucan
1 g, 10 g
GLU610
Isolichenan oligosaccharides (Cut-off< 10kDa)
Oligosaccharide mixture with average DP 30 to 50
hydrolyzed and purified from isolichenan polysaccharides by
ultra-filtration
10 mg, 100 mg, 1 g
GLU611
Isolichenan oligosaccharides (Cut-off:3<->10 kDa)
Oligosaccharide mixture with average DP 10 to 20
hydrolyzed and purified from isolichenan polysaccharides
by successive ultra-filtration steps
10 mg, 100 mg, 1 g
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OligoTech®
Glucan
Scleroglucan
Extraction from biomass
STRUCTURAL DESCRIPTION
Scleroglucan is a natural polysaccharide produced by fermentation of the filamentous fungus
Sclerotium rolfsii. Its chemical structure consists of a linear β(1-3) D-glucose backbone with
one β(1-6) D-glucose side chain every three main residue.
EXAMPLES OF BIOMASS SOURCES
Sclerotium rolfsii
ACTIVITIES AND USES
Scleroglucan is intended for drug delivery system improvement (Coviello et al., 2005.
Molecules, 10(1), 6-33). More precisely, scleroglucan is suitable for the preparation of
sustained release tablets and ocular formulations. This peculiar Polysaccharide exhibits
antiviral activities against Herpes Virus.
Scleroglucan also has applications in formulation for agriculture. In a view to replace Xanthan
gum, Scleroglucan could be especially useful in food manufacturing where a heating process is
involved, because of thermal stability that it exhibits (Survase et al.,2007. Fermentative
Production of Scleroglucan, Food Technol. Biotechnol. 45 (2) 107–118).
GLU700
Scleroglucan polysaccharide
β(1-3) linked D-glucose with side chain of β(1-6)
glucose every three unit.
[37339-90-5]
HO HO
OH
OH
OH
O
HO
O
OH
O
O
HO
O
O
OH
OH
HO
O
O
O
OH
n
1 g, 10 g, 100 g
30
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OligoTech®
Glucan
Lentinan
Extraction from biomass
STRUCTURAL DESCRIPTION
Lentinan is a polysaccharide obtained from Lentinula edodes (Berk./ Pegler, 1976) which is
an edible mushroom popular in East Asia known as Shiitake. This mushroom is one of the
most popular edible mushrooms in the world, production globally being second only to the
button mushroom Agaricus bisporus.
Lentinan is a beta glucan and its structure is reported as a β(1-3) linked D-glucose with
β(1-6) branching point.
EXAMPLES OF BIOMASS SOURCES
Shiitake (Lentinula edodes)
ACTIVITIES AND USES
Lentinan interest is increasing because of its high nutritional value and medicinal properties,
traditionally acknowledged by oriental cultures, especially in China and Japan.
Lentinan is attributed to have many functional properties such as antitumour and antiviral
properties, as well as antimicrobial potential.
Lentinula has shown neither evidence of being acutely toxic nor of having serious side effects.
Æ Recommended paper:
R. Hearst et al., 2009. Complementary Therapies in Clinical Practice, 15; 5–7.
GLU800
Lentinan polysaccharide
β(1-3) linked D-glucose with 2 side chains of single
β(1-6) D-glucose every five unit.
HO
HO
HO
OH
OH
HO
O
HO
OH
HO
O
HO
HO
O
O
O
O
HO
O
OH
HO
HO
OH
[37339-90-5]
O
O
O
OH
HO
O
OH
O
OH
HO
O
O
OH
HO
O
5
O
O
OH
10 mg, 100 mg, 1 g
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OligoTech®
Glucan
Pustulan
Extraction from biomass
STRUCTURAL DESCRIPTION
Pustulan was first isolated from Lichen Lasallia pustulata and is a linear Glucan having β(1-6)
linkage. Pustulan contains up to 2% of O-Acetyl groups (1 acetyl group every 10/12 glucose
units). This polysaccharide is distributed in lichen group of Umbilicariaceae.
EXAMPLES OF BIOMASS SOURCES
Lasallia pustulata
ACTIVITIES AND USES
Gentiooligosaccharides are useful as a taste improver for certain beverages.
Gentiooligosaccharides (D.P. 2–3) have also been noted as prebiotic substances showing
bifidogenetic activity. Such characteristics suggest the further potential of these
gentiooligosaccharides in food and biology.
GLU900
Pustulan polysaccharide
β(1-6) linked D-glucose polysaccharide
[37331-28-5]
OH
HO
HO
O
O
OH
HO
OH
OH
O
O
HO
n
O
GLU910
OH
OH
OH
100 mg, 1 g, 10 g
Gentio-oligosaccharides mixture
β(1-6) linked D-glucose oligomers prepared by
partial hydrolysis of pustulan.
Mixture of gentiobiose, gentriose, gentiotetraose...
100 mg, 1 g, 10 g
32
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OligoTech®
Xanthan
Extraction from biomass
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OligoTech®
Xanthan
Extraction from biomass
STRUCTURAL DESCRIPTION
Xanthan gum is a bacterial polysaccharide produced by a process involving fermentation of
glucose by the Xanthomonas campestris bacterium.
Xanthan gum chain consists of repeating modules of five sugar units. The backbone of the
polysaccharide chain consists of two β-D-glucose units linked through the 1 and 4 positions
and the side chain consists of two mannose and one glucuronic acid. The side chain is linked to
every other glucose of the backbone at the 3 position. About half of the terminal mannose
units have a pyruvic acid group linked as a ketal to its 4 and 6 positions. The other mannose
unit has an acetyl group at the 6 positions.
EXAMPLES OF BIOMASS SOURCES
Xanthomonas campestris
ACTIVITIES AND USES
Xanthan gum is used as a food additive (thickener, stabilizer) and rheological modifier. It is
accepted as a safe food additive in the USA, Canada and Europe, with E number E415. In
cosmetics xanthan gum is used to prepare water gels usually in conjunction with bentonite
clays. It is also used in oil-in-water emulsions to help stabilise the oil droplets against
coalescence. It has some skin hydrating properties.
GLU200
Xanthan gum polysaccharide
[98112-77-7]
COO H3C
O
HO
O
O
HOOC
O
O
HO
HO
OH
H3COOC
O
HO
HO
OH
OH
O
O
HO
O
O
O
O
O
OH
OH
n
34
1 g, 10 g
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OligoTech®
Chitin / Chitosan
Extraction from biomass
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OligoTech®
Chitin / Chitosan
Extraction from biomass
STRUCTURAL DESCRIPTION
Chitin, the second most abundant natural biopolymer, is an unbranched chain of β(1-4) Nacetyl-D-glucosamine units. It is present in the cell walls of fungi and is the principal
component of arthropod and lower animal exoskeletons (insect, crab, and shrimp shells…).
Chitin is analogous in chemical structure to cellulose and it may be regarded as a derivative of
cellulose, in which the hydroxyl groups of the second carbon of each glucose unit have been
replaced with acetamido (-NH(C=O)-CH3) groups. The degree of acetylation (DA) is generally
over 90%.
Chitosan is obtained by removing the acetyl groups (CH3-CO-) of the chitin. This process,
called deacetylation, releases amine groups (NH) and gives the chitosan a cationic
characteristic. The degree of acetylation is generally lower than 20%.
EXAMPLES OF BIOMASS SOURCES
Agaricus bisporus
Aspergillus niger
Exoskeletons of Crustaceans
ACTIVITIES AND USES
Chitin and chitosan have been proven useful for several medical and industrial purposes
(Kumar et al., 2000. Reactive and Functional Polymers, 46, 1-27). Many of the biological
activities reported for Chitin/Chitosan are surrounding the fields of as antimicrobial, anticancer,
antioxidant, and immunostimulant effects depending on their physico-chemical properties (SeKwon Kim et al., 2005. Carbohydrate Polymers 62, 357–368).
Æ Recommended paper:
Dai-Nghiep Ngo et al. 2009, Journal of Functional Foods, Vol. 1, Issue 2, pp 188-198.
36
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OligoTech®
Chitin
Extraction from biomass
GLU410
Chitin polysaccharide
β(1-4) linked N-acetyl-D-glucosamine Polymer
DA>90%
[1398-61-4]
OH
NHAc
O
O
HO
HO
O
O
NHAc
OH
GLU411
1 g, 10 g, 100g
n
Colloidal Chitin polysaccharide
β(1-4) linked N-acetyl-D-glucosamine Polymer
Suitable for enzyme assay (chitinases, …)
[1398-61-4]
100 mg, 1 g, 10 g
GLU432
Chitin oligosaccharide DP2
Chitinbiose
β(1-4) linked N-acetylglucosamine; DP:2.
Dimer prepared by hydrolysis of chitin; DA: 100%.
[35061-50-8]
OH
AcNH
O
HO
HO
O
HO
OH
O
AcNH
OH
NEW
GLU433
C16H28N2O11
FW 424.40
10 mg, 100 mg, 1 g
Chitin oligosaccharide DP3
Chitintriaose
β(1-4) linked N-acetylglucosamine; DP:3.
Trimer prepared by hydrolysis of chitin; DA: 100%.
[38864-21-0]
OH
HO
O
O
O
HO
OH
HO
O
NHAc
NHAc
OH
NEW
GLU434
OH
NHAc
O
HO
C24H41N3O16
FW 627.59
10 mg, 100 mg, 1 g
Chitin oligosaccharide DP4
Chitintetraose
β(1-4) linked N-acetylglucosamine; DP:4.
Tetramer prepared by hydrolysis of chitin; DA: 100%.
OH
HO
HO
O
NHAc
NEW
OH
NHAc
O
O
O
HO
[2706-65-2]
OH
NHAc
O
C32H54N4O21
FW 830.78
HO
OH
O
HO
O
NHAc
OH
10 mg, 100 mg, 1 g
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OligoTech®
Chitin
Extraction from biomass
GLU435
Chitin oligosaccharide DP5
Chitinpentaose
β(1-4) linked N-acetylglucosamine; DP:5.
Pentamer prepared by hydrolysis of chitin; DA: 100%.
[36467-68-2]
OH
HO
O
O
O
HO
OH
NHAc
O
HO
C40H67N5O26
FW 1033.97
NHAc
OH
HO
O
NHAc
OH
3
NEW
10 mg, 100 mg, 1 g
GLU436
Chitin oligosaccharide DP6
Chitinhexaose
β(1-4) linked N-acetylglucosamine; DP:6.
Hexamer prepared by hydrolysis of chitin; DA: 100%.
[38854-46-5]
OH
HO
O
O
O
HO
OH
NHAc
O
HO
C48H80N6O31
FW 1237.16
NHAc
OH
HO
O
NHAc
OH
4
NEW
10 mg, 100 mg
GLU437
Chitin oligosaccharide DP7
Chitinheptaose
β(1-4) linked N-acetylglucosamine; DP:7.
Heptamer prepared by hydrolysis of chitin; DA: 100%.
[38854-46-5]
OH
HO
OH
NHAc
O
HO
O
O
O
HO
OH
NEW
OH
HO
O
NHAc
GLU440
C56H93N7O36
FW 1440.35
NHAc
5
10 mg, 100 mg
Chitin-Oligosaccharides Kit
Individually packaged Chitin-oligosaccharide kit from Chitinbiose
(DP2) to Chitinheptaose (DP7).
NEW
Each proposed in 10 mg pack size
Please contact us for custom oligosaccharide length and grade tailored to your need
38
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OligoTech®
Chitoosan
Extraction from biomass
GLU420
Chitosan polysaccharide
β(1-4) linked D-glucosamine polymer
DA<10%; Viscosimetry 50 Cps
[9012-76-4]
OH
O
HO
HO
O
NH2
GLU421
NH2
O
O
OH
1 g, 10 g, 100 g
n
Chitosan oligosaccharides mixture
β(1-4) linked D-glucosamine; average range DP:2 to 25.
Oligomer mixture prepared by hydrolysis of chitosan polymer.
DA<20%.
100 mg, 1 g, 10 g
GLU422
Chitosan oligosaccharides DP60
β(1-4) linked D-glucosamine; average DP:60
Oligomers prepared by hydrolysis of chitosan; DA<20%.
10 mg, 100 mg
GLU423
Chitosan oligosaccharides DP40
β(1-4) linked D-glucosamine; average DP:40
Oligomers prepared by hydrolysis of chitosan; DA<20%.
10 mg, 100 mg
GLU424
Chitosan oligosaccharides DP24
β(1-4) linked D-glucosamine; average DP:24
Oligomers prepared by hydrolysis of chitosan; DA<20%.
10 mg, 100 mg
GLU425
Chitosan oligosaccharides DP12
β(1-4) linked D-glucosamine; average DP:12
Oligomers prepared by hydrolysis of chitosan; DA<20%.
10 mg, 100 mg
GLU426
Chitosan oligosaccharides DP6
β(1-4) linked D-glucosamine; average DP:6
Oligomers prepared by hydrolysis of chitosan; DA<20%.
10 mg, 100 mg
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OligoTech®
Ulvan
Extraction from biomass
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OligoTech®
Ulvan
Extraction from biomass
STRUCTURAL DESCRIPTION
Ulvans are structural acid polysaccharides present in cell wall of green algae (Ulva and
Enteromorpha). They are highly sulphated and essentially composed with rhamnose 3-sulfate,
xylose, xylose 2-sulfate, glucuronic acid and iduronic acide units. The four recurrent units are:
x Ulvanobiuric 3-sulfate type A acid
x Ulvanobiuric 3-sulfate type B acid
x Ulvanobiose 3-sulfate acid
x Ulvanobiose 2’, 3 disulfate acid
Ulvanobiuric 3-sulfate type A acid
β(1-4) D-GlcA- α(1-4) L-Rha 3 sulfate
Ulvanobiose 3-sulfate acid
β(1-4)-D-Xyl- α(1-4)-L-Rha 3 sulfate
Ulvanobiuric 3-sulfate type B acid
β(1-4) L-IdoA- α(1-4)-L-Rha 3 sulfate
Ulvanobiose 2’, 3 disulfate acid
β(1-4) D-Xyl 2-sulfate- α(1-4)-L-Rha 3 sulfate
EXAMPLES OF BIOMASS SOURCES
Ulva sp.
Enteromorpha sp.
ACTIVITIES AND USES
Ulvan presents several potentially valuable biological properties for agricultural, food and
pharmaceutical applicationsamong which Anticoagulant activities (heparin like), Antioxydant
activities, Antihyperlipidemic activities, Antitumoral activities.
Æ Recommended paper: Lahaye and Robic, 2007. Biomacromolecules, vol. 8, N°6.
42
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OligoTech®
Ulvan
Extraction from biomass
ULV100
Ulvan polysaccharides from Ulva sp. Native grade
Polysaccharides extracted and purified from the green seaweed Ulva
armoricana.
Molecular weight generally observed from 90 to 500 kDa.
(SEC & 1H NMR characterization).
1 g, 10 g, 100 g
ULV102
Ulvan polysaccharides from Ulva sp. Fine Grade
Polysaccharide extracted from the green seaweed Ulva armoricana and purified
by Anion Affinity. Low Glucan content
Molecular weight generally observed over 300 kDa.
(SEC & 1H NMR characterization). Low Glucan content.
100 mg, 1 g, 10 g
ULV101
Ulvan polysaccharides from Enteromorpha sp. Native grade
Polysaccharides extracted and purified from the green seaweed Enteromorpha
intestinalis.
Molecular weight generally observed around 400 kDa.
(SEC & 1H NMR characterization).
1 g, 10 g, 100 g
ULV103
Ulvan polysaccharides from Enteromorpha sp. Fine grade
Polysaccharide extracted from the green seaweed Enteromorpha intestinalis
and purified by Anion Affinity. Low Glucan content.
Molecular weight generally observed over 300 kDa.
(SEC & 1H NMR characterization). Low Glucan content.
100 mg, 1 g, 10 g
ULV010
Ulvan oligosaccharides (cut-off<10kDa) from Ulva sp.
Oligosaccharides obtained from Ulva armoricana polysaccharide hydrolysis.
Purified by 10kDa cut-off ultrafiltration.
10 mg, 100 mg, 1 g
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OligoTech®
Ulvan
Extraction from biomass
ULV011
Ulvan oligosaccharides (cut-off<10kDa) from Enteromorpha sp.
Oligosaccharides obtained from Enteromorpha intestinalis polysaccharide
hydrolysis.
Purified by 10kDa cut-off ultrafiltration.
10 mg, 100 mg, 1 g
ULV001
Ulvan oligosaccharides (cut-off: 3<->5kDa) from Ulva sp.
Oligosaccharides obtained from Ulva armoricana polysaccharide hydrolysis.
Purified by 3kDa and 5kDa cut-off ultrafiltration steps.
10 mg, 100 mg, 1 g
ULV002
Ulvan oligosaccharides (cut-off: 1<->3kDa ) from Ulva sp
Oligosaccharides obtained from Ulva armoricana polysaccharide hydrolysis.
Purified by 1kDa and 3kDa cut-off ultrafiltration steps.
10 mg, 100 mg, 1 g
ULV003
Ulvan oligosaccharides (cut-off: 650 Da<->1kDa) from Ulva sp.
Oligosaccharides obtained from Ulva armoricana polysaccharide hydrolysis.
Purified by 650Da and 1kDa cut-off ultrafiltration steps.
10 mg, 100 mg, 1 g
ULV005
Ulvan oligosaccharides (cut-off: 3<->5kDa) from Enteromorpha sp.
Oligosaccharides obtained from Enteromorpha intestinalis polysaccharide
hydrolysis.
Purified by 3kDa and 5kDa cut-off ultrafiltration steps.
10 mg, 100 mg, 1 g
ULV006
Ulvan oligosaccharides (cut-off: 1<->3kDa ) from Enteromorpha sp.
Oligosaccharides obtained from Enteromorpha intestinalis polysaccharide
hydrolysis.
Purified by 1kDa and 3kDa cut-off ultrafiltration steps.
10 mg, 100 mg, 1 g
ULV007
Ulvan oligosaccharides (cut-off: 650 Da<->1kDa) from Enteromorpha
sp
Oligosaccharides obtained from Enteromorpha intestinalis polysaccharide
hydrolysis.
Purified by 650Da and 1kDa cut-off ultrafiltration steps.
10 mg, 100 mg, 1 g
Please contact us for custom ulvan oligosaccharide length tailored to your need
44
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OligoTech®
Fucooidann / Galactofucan
Extraction from biomass
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OligoTech®
Fucooidan / Galactofucan
Extraction from biomass
STRUCTURAL DESCRIPTION
Fucoidans are sulfated fucan polysaccharides occurring in brown marine seaweeds cell wall
(Phaeophyceae, mainly Fucales and Laminariales), in sea urchin egg gelatinous coat, and in
sea cucumber cuticule.
Numerous variations of the basic structure are found in different species of Phaeophycea. The
structure of fucan polysaccharide consists of α(1-3) linked sulphated L-fucose backbone in
some order (eg Laminariales) with alternating α(1-3) and α(1-4) linked residues in other
orders (eg Fucales). Other units (like galactose) and substitutions (acetate) also occur.
Galactofucan is a sulphated (10-30%) backbone dominated by both 3-linked α-fucopyranose
and β-galactopyranose moieties. Galactofucan can be extracted from the brown seaweed
Undaria pinnatifida and Saccharina longicruris.
O
O
OSO3OH
OH
O
O
OH
-
O3SO
O3SO
OH
OH
OH
O
OH
OH
-
O3SO
O
OH
-
O 3SO
OH
O
O
O
OH
OH
OH
O
O
OSO3-
OH
O
OH
O
O
OSO3-
OSO3-
O
O
O
OSO3-
O
O
OH
O
O
OSO3-
OSO3-
HO
OH
OH
HO
O
OH
O
O
O
O
OH
O
O
O
OH
-
OH
OSO3-
O
OSO3
O
O
O
O
-
HO
OH
OSO3-
O
OSO 3- OH
OSO3-
O
O
OSO3-
O
O
OSO3-
O
OH
OH
OH
Versatility of fucoidan structures
POSSIBLE BIOMASS SOURCES
Fucus vesiculosus Undaria pinnatifida Ascophyllum n. Durvillea antarctica
ACTIVITIES AND USES
Fucoidan and galactofucan exhibit numerous potential therapeutic activities. Noteworthy,
they have been shown to have anti-inflammatory, anticoagulant/heparin-like activities,
antiviral and antiparasitic activities. They can act has antiangiogenic and antitumoral agents.
Æ Recommended papers:
x
x
46
Synytsya et al., 2010. Carbohydrate Polymers, vol.81, pp 41-48.
Rioux et al., 2010. Phytochem., vol.71.
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OligoTech®
Fucooiddan / Galactofucan
Extraction from biomass
FUC100
Fucoidan polysaccharide from Fucus vesiculosus
Highly sulphated L-fucose polymer extracted and
purified
from
the
brown
seaweed
Fucus
vesiculosus. Non-reduced extremity.
1
H NMR characterization
[9072-19-9]
100 mg, 1 g, 10 g
FUC300
Fucoidan polysaccharide from Chorda filum
Highly sulphated L-fucose polymer extracted and
purified from the brown seaweed Chorda filum.
Non-reduced extremity.1H NMR characterization
[9072-19-9]
100 mg, 1 g, 10 g
FUC400
Fucoidan polysaccharide from Ascophyllum nodosum
Highly sulphated L-fucose polymer extracted and
purified from the brown seaweed Ascophyllum
nodosum.
Non-reduced extremity. 1H NMR characterization
[9072-19-9]
100 mg, 1 g, 10 g
FUC500
Fucoidan polysaccharide from Durvillea antarctica
Highly sulphated L-fucose polymer extracted and
purified from the brown seaweed Durvillea
antarctica.
Non-reduced extremity.1H NMR characterization
[9072-19-9]
100 mg, 1 g, 10 g
FUC200
Galactofucan polysaccharide from Undaria pinnatifida
Sulfated polymer of L-fucose and D-galactose
extracted and purified from the brown seaweed
Undaria pinnatifida.
Non-reduced extremity.1H NMR characterization
[9061-39-6]
100 mg, 1 g
FUC600
Fucoidan polysaccharide Kit
Individually packaged Highly sulphated L-fucose
polymer extracted and purified from 4 species of
brown seaweed.
NEW
Each proposed in 100 mg pack size
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OligoTech®
Fucooidan / Galactofucan
Extraction from biomass
FUC110
Fucoidan oligosaccharides (Cut-off<10kDa) from Fucus vesiculosus
Highly sulphated L-fucose oligomer obtained from the brown seaweed Fucus
vesiculosus polysaccharide hydrolysis.
Purified by 10kDa cut-off ultrafiltration.
10 mg, 100 mg, 1 g
FUC310
Fucoidan oligosaccharides (Cut-off<10kDa) from Chorda filum
Highly sulphated L-fucose oligomer obtained from the brown seaweed Chorda
filum polysaccharide hydrolysis.
Purified by 10kDa cut-off ultrafiltration.
10 mg, 100 mg, 1 g
FUC410
Fucoidan oligosaccharides (Cut-off<10kDa) from Ascophyllum n.
Highly sulphated L-fucose oligomer obtained from the brown seaweed
Ascophyllum nodosum polysaccharide hydrolysis.
Purified by 10kDa cut-off ultrafiltration.
10 mg, 100 mg, 1 g
FUC510
Fucoidan oligosaccharides (Cut-off<10kDa) from Durvillea a.
Highly sulphated L-fucose oligomer obtained from the brown seaweed
Durvillea Antarctica polysaccharide hydrolysis.
Purified by 10kDa cut-off ultrafiltration.
10 mg, 100 mg, 1 g
FUC210
Galactofucan oligosaccharides (Cut-off<10kDa) from Undaria
pinnatifida
Highly sulphated Galactofucan oligomer obtained from the brown seaweed
Undaria pinnatifida polysaccharide hydrolysis.
Purified by 10kDa cut-off ultrafiltration.
10 mg, 100 mg
Please contact us for custom oligosaccharide length and grade tailored to your need
48
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OligoTech®
Xylan
Extraction from biomass
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OligoTech®
Xylan
Extraction from biomass
STRUCTURAL DESCRIPTION
Xylan is a wide family of highly complex polysaccharides that are found in plant cell walls
(Hardwood such as birch, larch woods) and some algae. Xylan, the most abundant of the
hemicelluloses in plant cell walls, has a linear backbone structure consisting of β-D-(1-4) linked
xylosyl residues that, depending on its origin, may contain branches of L-arabinofuranosyl,
acetyl, D-glucuronosyl and 4-O-methylglucuronosyl residues.
Xylans are cell wall constituants:
x Of some green algae (mainly macrophytic siphonous genera, like Codium, Caulerpa or
Bryopsis Genus). The linear backbone structure is then based on β-D-(1-3)-xylose chain.
x Of some red algae (Nemaliales and Palmariales). According to their origins, they may be
made of β(1-3) and/or β(1-4)-D-xylose residues and may contain galactopyranosyl, uronic
acids, sulfate and phosphate residues.
POSSIBLE BIOMASS SOURCES
Palmaria palmata
ACTIVITIES AND USES
Xylan represents an interesting source of raw material for the preparation of modified
polysaccharides with novel biological activities. In particular, anticoagulant, antithrombotic and
antiviral activities has been shown for sulphated or phosphorylated xylan polysaccharides (P.
Mandal, et al., Int. J. Biol. Macromol.2010).
Æ Recommended paper:
E. Deniaud et al. International Journal of Biological Macromolecules ; 33 (2003) 9–18.
50
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Xylan
Extraction from biomass
XYL100
Xylan polysaccharide from Palmaria palmata
Xylan polysaccharide is extracted and purified from the red seaweed Palmaria
palmata. β(1-3) and β(1-4) D-xylose linked polymer.
β(1-3)/β(1-4) ratio 1:4
Xylose, ≥98% HPAEC
OH
OH
O
O
HO
O
OH
OH
HO
HO
O
O
O
HO
O
O
O
n
1 g, 10 g, 100 g
XYL101
Glucurono-Arabinoxylan polysaccharide from wheat bran
Glucurono-Arabinoxylan polysaccharide is extracted and purified from wheat
bran
β(1-4)-D-xylose linked polymer branched with arabinose and glucuronic acid.
100 mg, 1 g, 10 g
XYL110
Xylan oligosaccharides XOs (Cut-off<10kDa) from Palmaria p.
Xylan oligosaccharides (XOs) are obtained from Palmaria palmata
polysaccharide hydrolysis. Purified by 10kDa cut-off ultrafiltration.
Degree of polymerization (DP): generally observed from 2 to 25.
10 mg, 100 mg, 1 g
XYL111
Xylan oligosaccharides XOs (cut-off: 650Da<->3kDa) from Palmaria p.
Xylan oligosaccharides (XOs) are obtained from Palmaria palmata polysaccharide
hydrolysis.
Purified by 3kDa and 650 Da cut-off ultrafiltration steps.
10 mg, 100 mg, 1 g
Please contact us for custom Xylo-oligosaccharide length tailored to your need
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OligoTech®
Galactan
Extraction from biomass
Arabinogalactan
Carrageenan
Agar
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OligoTech®
Galactan
Arabinogalactan
Extraction from biomass
STRUCTURAL DESCRIPTION
Green seaweeds Codium fragile and Codium vermilara biosynthesize water-soluble sulfated
arabinogalactans (AG) and minor α(1-4) D-glucans and β(1-4) D-mannans. Arabinogalactan
polysaccharides are composed of 3-linked β-D-galactopyranose and β-L-arabinopyranose
residues; they are highly sulfated and potentially substituted with pyruvic acid ketals.
Moreover, it has been found that polysaccharide components cellulose, galactomannan and
arabinogalactan-proteins (AGPs) represent about 50% of dry weight of coffee beans, from
which AGPs constitute about 15%.
POSSIBLE BIOMASS SOURCES
Codium fragile
Coffee beans
ACTIVITIES AND USES
Arabinogalactan (AG) has a wide spectrum of possible uses. It can be employed, for
example, as an adhesion-promoting agent in cardboard production, binding agent for gouache
and watercolor, thickener in textile industry. AG has also been proposed for use in
pharmaceutical industry as a binder in pill production, emulsifying agent for stabilizing oil
emulsions (E number E409).
Arabinogalactans become important due to their prebiotic, cholesterol-lowering, emulsifying,
immunomodulatory, and other properties which make from these glycoconjugates
commercially important article for food and pharmaceutical industries (Capek et al., 2009.
Carbohydrate Polymers).
Æ Recommended paper:
M. Ciancia et al.; International Journal of Biological Macromolecules. 41, (2007), 641–649.
54
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Galactan
Extraction from biomass
GAL100
Arabinogalactan
Sulfated Arabinogalactan polysaccharide (from Codium f.) Native grade
Arabinogalactan polysaccharide is extracted and purified from the green
seaweed Codium fragile. The sulphated polysaccharide is composed of 3-linked
β-D-galactopyranose (C4 or C6 sulfated) and β-L-arabinopyranose (C2 or C3
sulfated) residues.
Polysaccharide extremity is non-reduced.
1 g, 10 g
GAL101
Sulfated Arabinogalactan polysaccharide (from Codium f.) Fine grade
Arabinogalactan polysaccharide is extracted from the green seaweed Codium
fragile and purified by Anion Affinity.
Low Mannan & Glucan content.
Polysaccharide extremity is non-reduced.
100 mg, 1g
GAL110
Sulfated Arabinogalactan oligosaccharides (Cut-off<10kDa)
Sulfated Arabinogalactan oligosaccharide obtained from the hydrolysis of green
seaweed Codium fragile polysaccharide.
Purified by 10kDa cut-off ultrafiltration
10 mg, 100 mg
GAL111
Sulfated Arabinogalactan oligosaccharides (Cut-off: 3kDa<->10kDa)
Sulfated Arabinogalactan oligosaccharide obtained from the hydrolysis of green
seaweed Codium fragile polysaccharide.
Purified by successive 10kDa and 3 kDa cut-off ultrafiltration
10 mg, 100 mg
GAL112
Sulfated Arabinogalactan oligosaccharides (Cut-off<3kDa)
Sulfated Arabinogalactan oligosaccharide obtained from the hydrolysis of green
seaweed Codium fragile polysaccharide.
Purified by 3 kDa cut-off ultrafiltration
10 mg, 100 mg
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Galactan
Carrageenan
Extraction from biomass
STRUCTURAL DESCRIPTION
Carrageenan is a generic term for several polysaccharides also extracted from red seaweeds
(Rhodophyceae). Carrageenan compounds differ from agar in that they have sulfate groups (OSO3-) in place of some hydroxyl groups. Carrageenans are water-soluble galactans extracted
from some red seaweeds (mainly Chondrus, Euchema and Gigartina Genuses). They have a
repeating backbone of 3-linked β-D-galactose (G-units) and 4-linked α-D-galactose (D-units),
containing a varying degree of sulphate (from 20 to 50% sulfation degree). 4-linked α-Dgalactose residues may also be found as 3’ and 6’ anhydro residues (DA-units).
The commercially important κ-carrageenan contains a 3,6-anhydro-D-galactopyranose
(AnGalp) in place of α-D-galactopyranose, giving it gelling properties.
The addition of a 2-O-sulfo group to the κ-carrageenan affords another commercially
important carrageenan, L-carrageenan.
Carrageenan classification is based on number, position of sulfo groups and presence of 3,6anhydro-D-galactopyranose (AnGalp) in place of α-D-galactopyranose (Nomenclature given in
Knutsen et al.1994. Botanica marina, 37, 163-169).
POSSIBLE BIOMASS SOURCES
Chondrus crispus
Agardhiella tenera
ACTIVITIES AND USES
In the food industry field, carageenan are thickening suspending, gelling and stabilizing
agents (Food additive with E number 407). Antiviral (HSV, HIV), Antitumor activities.
Cosmetics (anti-oxydant activity, antihyperlipidemic). Carrageenans have shown plant health
activities.
κ-carrageenans have shown immunomodulation and antitumor activities (H. Yuan et al.
2006/ Cancer Letters 243; 228–234).
Æ Recommended paper:
V.L. Campo et al. / Carbohydrate Polymers 77 (2009) 167–180
56
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Galactan
Carrageenan
Extraction from biomass
GAL200
Kappa-Carrageenan polysaccharides
Kappa (κ) group containing polysaccharides which
residues are C4-sulfated β-D-galactopyranosyl. B unit
contains 3,6 anhydo bridge.
[1114-20-8]
O
O
OSO 3- OH
O
O
OH
O
O
OH
On request
GAL300
Lambda-Carrageenan polysaccharides
Lambda (O) Group containing polysaccharides which
residues are C2 sulfated β-D-galactopyranosyl.
OH
[9064-57-7]
OH
O
OSO3-
O
OH
O
-
O3SO
O
O
OSO3-
On request
GAL400
Iota-Carrageenan polysaccharides
Iota (L) Group containing polysaccharides which residues
are C4 sulfated E-D-galactopyranosyl. G4S-DA2S
[9062-07-1]
O
O
OSO3- OH
O
O
-
O3SO
O
O
OH
On request
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Galactan
Agar
Extraction from biomass
STRUCTURAL DESCRIPTION
Agar is extracted from red seaweed (mainly from Gelidium and Gracilaria genera) and is used
in many foods as a gelling agent. Agar is a polymer of agarobiose, a disaccharide composed of
D-galactose and 3,6-anhydro-L-galactose.
POSSIBLE BIOMASS SOURCES
Gracilaria sp.
ACTIVITIES AND USES
Highly refined agarose is an industrially important high value material and is extensively used
in biotechnology and molecular biology applications (used as a medium for culturing bacteria,
cellular tissues, and for DNA fingerprinting).
In the food industry field, Agarose is widely used as stabilizer, gelling agent and thickener (E
number E406). Laxative properties and stabilizer of pharmaceutical products.
GAL500
Agar polysaccharides
Polysaccharide extracted from red seaweed Gracilaria
composed of β-D-Galactose and 3,6 anhydro-Lgalactose disaccharide repeating units
OH
O
OH
58
CH2
O
O
OH
[9002-18-0]
O
O
OH
On request
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OligoTech®
Mannan
Extraction from biomass
Mannan
Xylomannan
Galactomannan
Glucomannan
Galactoglucomannan
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Mannan
Mannan
Extraction from biomass
STRUCTURAL DESCRIPTION
Mannan that consists of β(1-4)-mannosyl residues is abundant in nature, and is obtained as a
pure homopolymer from the endosperm of the monocotyledonous (e.g. Arecaceae family),
such as ivory nuts (Phytelephas sp.), dates (Phoenix dactylifera), as well as from the cell walls
of several green algae belonging to the Codiaceae and Dasycladaceae families. It is also
distributed within some species from Apiaceae, Rubiaceae (Coffea sp.) and Asteraceae.
Mannan is found to be a major constituent of Mycobacteriae and yeast cell wall representing
principal surface antigen, with species-specific structure and composition. Saccharomyces
cerevisiae mannan differs, for example from that of C. albicans by side chain structure as well
as substitution frequency.
Mannan is often compared to another abundant natural polymer, cellulose, because of the
similarities in their chemical structures.
POSSIBLE BIOMASS SOURCES
Coffee beans
Ivory nuts
ACTIVITIES AND USES
Mannans are known as important biological response modifiers, which can exhibit a
remarkable range of immunopharmacological and therapeutic activities. Aloe species contain
O-acetyl-β-D-(1-4) mannan, which have been reported to show antiviral and antiproliferative
properties in vivo. Mannan from Aloe saponaria inhibits the proliferative response in normal
and tumoral cells (C.L.O. Petkowicz et al., 2007. Carbohydrate Polymers, 69, 659–664).
Æ Recommended paper:
R. Hori et al., 2007. Carbohydrate Polymers, 70, 298–303.
60
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Mannan
Mannan
Extraction from biomass
MAN800
Mannan polysaccharide (Ivory Nut or Tagua)
β(1-4) linked D-mannopyranosyl residues extracted
and purified from Ivory Nut (Tagua).
[37251-487-1]
Mannose content >90%
O
OH
HO O
OH
HO O
O
HO
O
HO
n
1 g, 10 g, 100 g
MAN801
Acemannan polysaccharide (Aloe vera)
β(1-4) linked D-mannopyranosyl residues partially O-acetylated extracted
and purified from Aloe vera.
10 mg, 100 mg
MAN810
Mannan oligosaccharides (cut-off<10kDa)
β(1-4) linked D-mannose oligosaccharides prepared by mannan or
galactomannan polysaccharide hydrolysis. Purified by 10 kDa cut-off
ultrafiltration.
Degree of polymerization (DP): generally observed from 2 to 24
O
OH
HO O
HO
OH
HO O
O
O
HO
n
n=1 to 12
10 mg, 100 mg, 1 g
Please contact us for custom Manno-oligosaccharide length tailored to your need
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Mannan
Xylomannan
Extraction from biomass
STRUCTURAL DESCRIPTION
The red seaweed Nothogenia fastigiata synthesizes a complex system of polysaccharides
comprising neutral xylans of the β-D-(1-3), β-D-(1-4)-mixed linkage type, sulfated xylogalactans of the agaroid type and a family of sulfated xylomannans. These polysaccharides
are α(1-3)-linked O-mannans with position 2- and 6-sulfated. The main mannose backbone has
β-D-(1-2)-linked O-xylose side chains.
POSSIBLE BIOMASS SOURCES
Nothogenia fastigiata
ACTIVITIES AND USES
Antiviral activity, Herpes simplex virus type 1 and 2 in vitro activity: inhibits replication of
Herpes simplex (HVS) 1 and 2, human cyclomegalovirus (HCLV), respiratory syncytial virus
(RSV), Influenza A & B, Junin virus, Tacaribe, Simian virus (P. Mandal et al., 2008.
Phytochem., vol. 69, 2193–2199).
Xylomannan is a newly discovered antifreeze molecule, found in the freeze-tolerant Alaskan
beetle Upis ceramboides (Walters KR Jr et al., 2009. PNAS; 106 (48):20210-5).
MAN100
Sulfated Xylomannan polysaccharides
Sulfated α(1-3) linked Mannose Polymers + Branched β(1-2)-Xylose
Mannopyranosyl residues: C2 and C4 sulfated.
HO
HO
HO
OSO3HO O
OH
O
HO
O
HO
O
OSO3O
OH O
HO
O
O
O
On request
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Mannan
Galactomannan
Extraction from biomass
STRUCTURAL DESCRIPTION
Among storage polysaccharides of higher plants, galactomannans constitute the second
most abundant group. They are found especially in legume seeds, and have different degrees
of side-chain substitution, molecular masses, and fine structures. Their structure consists of a
main chain of (1-4)-linked β-D-mannopyranosyl units substituted by α-D-galactopyranosyl
units and are distinguished by the content of D-mannopyranosyl units which ranges from 60
to 80%.
Galactomannans can also be found in Fungus species such as Aspergillus. Their related
structure consists of a linear α-linked mannan core with side chains of an average of five
β(1-5) linked galactofuranosyl residues.
POSSIBLE BIOMASS SOURCES
Galactomannan mainly found in leguminous seeds:
x
x
x
x
Fenugreek Gum, mannose:galactose Ratio~1:1
Guar Gum, mannose:galactose Ratio~2:1 – E412
Tara Gum, mannose:galactose Ratio~3:1 – E417
Carob Gum, mannose:galactose Ratio ~4:1 – E410
Fenugreek
Carob
Guar
ACTIVITIES AND USES
Galactomannans are polysaccharides widely used as emulsion stabilizers in the
pharmaceutical and food industries (monitoring the viscosity of the water phase) which are
mainly obtained from endosperm of leguminous seeds.
Given their low toxicity, they are also used in the cosmetic and biomedical industries,
either alone or conjugated to antimumoral drugs. Guar and Locust Bean Gum (LBG) are
commonly used in ice cream to improve texture and reduce ice cream meltdown.
Tara is seeing growing acceptability as a food ingredient but is still used to a much lesser
extent than guar or LBG. Guar has the highest usage in foods. Lubricants to improve eye
comfort. This polysaccharides from Caesalpinia spinosa also revealed immunoregulatory
activities in human DCs and could be possibly used as antitumoral adjuvant.
Æ Recommended paper :
S.P. Santander et al., International Immunopharmacology 11 (2011) 652–660.
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Mannan
Extraction from biomass
MAN200
Galactomannan
Galactomannan polysaccharides from Guar
β(1-4) linked D-mannopyranosyl units substituted by
α(1-6)-D-galactopyranosyl units. Ratio~2:1.
Viscosimetry (1%, H2O):2400-3400 cps
MAN201
[9000-30-0]
1 g, 10 g
Galactomannan polysaccharides from Carob (locust bean gum)
β(1-4) linked D-mannopyranosyl units substituted by
α(1-6)-D-galactopyranosyl units. Ratio~4:1.
Viscosimetry (1%, H2O):2500-3000 cps
MAN202
[9000-40-2]
1 g, 10 g
Galactomannan polysaccharides from Fenugreek
β(1-4) linked D-mannopyranosyl units substituted by
α(1-6)-D-galactopyranosyl units. Ratio~1:1.
[9000-40-2]
100mg, 1 g, 10 g
MAN213
Galactomannan oligosaccharides DP3 from Carob
Mixture of β(1-4) linked D-mannose oligosaccharides
Prepared by controlled hydrolysis from carob
Average DP: 3.
Average observed Man/Gal Ratio~ 4-7.
10 mg, 100 mg, 1 g
MAN215
Galactomannan oligosaccharides DP5 from Carob
Mixture of β(1-4) linked D-mannose oligosaccharides
Prepared by controlled hydrolysis from carob
Average DP: 5.
Average observed Man/Gal Ratio~ 4-7.
10 mg, 100 mg, 1 g
MAN219
Galactomannan oligosaccharides DP9 from Carob
Mixture of β(1-4) linked D-mannose oligosaccharides
Prepared by controlled hydrolysis from carob
Average DP: 9.
Average observed Man/Gal Ratio~ 4-7.
10 mg, 100 mg, 1 g
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Mannan
Galactomannan
Extraction from biomass
MAN300
α-Digalactosyl mannopentaose
Manβ1-4(Galα1-6)Manβ1-4(Galα1-6)Manβ1-4Manβ1-4Man
OH
OH
OH
OH
O
O
HO
HO
OH
OH
HO
O
O
OH
HO O
OH
HO O
O
O
HO
HO
OH
HO O
OHO
OHO
O
HO
O
HO
OH
HO
10 mg, 100 mg
MAN400
α-galactosyl Mannobiose & Mannotriose
Manβ1-4(Galα1-6)Man + Manβ1-4Manβ1-4Man
OH
OH
O
HO
OH
O
OH
HO O
HO
OHO
HO
O
HO
OH
OH
OH
HO O
HO
HO
OH
HO O
OH
O
O
O
HO
OH
HO
10 mg, 100 mg
MAN500
α-galactosyl Mannotriose
Manβ1-4Manβ1-4(Galα1-6)Man
OH
OH
O
HO
OH
O
HO
HO
OH
HO O
OH
HO O
O
OHO
O
HO
OH
HO
10 mg, 100 mg
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Mannan
Extraction from biomass
Glucomannan
STRUCTURAL DESCRIPTION
Glucomannan is a dietary fiber obtained from tubers of Amorphophallus konjac cultivated in
Asia. Flour from the konjac tubers is used to make Japanese shirataki noodles which are very
low in calories. The polysaccharide consists of glucose (G) and mannose (M) in a proportion of
5:8 joined by β(1-4) linkages. The basic polymeric repeating unit has the pattern:
GGMMGMMMMMGGM. Short side chains of 11-16 monosaccharides occur at intervals of 50-60
units of the main chain attached by β(1-3) linkages. Also, acetate groups on carbon 6 occur at
every 9-19 units of the main chain. Hydrolysis of the acetate groups favors the formation of
intermolecular hydrogen bonds that are responsible for the gelling action.
POSSIBLE BIOMASS SOURCES
Glucomannan comprises 40% by dry weight of the roots or corm of the konjac plant. It is
also a hemicellulose that is present in large amounts in the wood of conifers and in smaller
amounts in the wood of dicotyledons.
Konjac
Conifers
ACTIVITIES AND USES
As a food additive, glucomannan is used as an emulsifier and thickener. It has E number
E425(ii). Glucomannan is used as a hunger suppressant because it produces a feeling of
fullness by creating very viscous solutions that retard absorption of the nutrients in food. One
gram of this soluble polysaccharide can absorb up to 200 ml of water, so it is also used for
absorbent articles such as disposable diapers and sanitary napkins. Glucomannan also makes
up the majority of shirataki noodles.
Glucomannans show health benefits for: constipation, cholesterol, diabetes, obesity (An et
al., 2010. Carbohydrate Polymers).
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Mannan
Glucomannan
Extraction from biomass
MAN600
Glucomannan polysaccharide from Konjac
Portion (GGMM) of the glucomannan repeating unit randomly
distributed. The second glucose has an acetate group.
[37220-17-0]
DA (acetylation %) generally observed <15%. M/G ratio ~ 1.5
DA and Mannose/glucose ratio performed by HPAEC and 1H NMR
OH
OAc
OH
O
O
O
HO
O
HO
HO
O
O
OH
OH
OH
OH
O
O
HO
O
OH
1 g, 10 g
MAN610
Glucomannan oligosaccharides (Cut-off<10kDa)
Oligomers obtained from glucomannan polysaccharide hydrolysis and purified by
10kDa cut-off ultrafiltration.
DA and Mannose/glucose ratio performed by HPAEC and 1H NMR
O
O
HO
O
OH
OH
OAc
OH
O
HO
HO
O
O
OH
OH
O
HO
OH
O
O
OH
n
10 mg, 100 mg, 1 g
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Mannan
Galactoglucomannan
Extraction from biomass
STRUCTURAL DESCRIPTION
Galactoglucomannans are polysaccharides consisting of a mannose backbone with side
groups. Main chain is composed of β(1-4) linked D-mannopyranosyl units interspersed with a
lower number of β(1-4) linked D-glucopyranosyl units. Single (1-6)-linked α-galactopyranosyl
units are found as side groups branched to the mannopyranosyl units. In softwood, the GGMs
are O-acetylated at C-2 and C-3 of the mannosyl units. Their structures are numerous due to
their ability to be acetylated and due to their wide distribution among higher plants
(hemicellulose). They are soluble in alkali.
POSSIBLE BIOMASS SOURCES
Galactoglucomannans (i.e GGMs) are a large group of polysaccharides which are prominent
components of coniferous woods (almost 20% of dry matter from softwoods are hemicellulosic
galactoglucomannan).
GGMs are also found in other wood species as well as in the primary cell walls of other plants,
fruits, and seeds, such as flax, tobacco plants, or kiwifruit.
Spruce (Picea abies)
ACTIVITIES AND USES
Plant Health Product acting on growth development 㻌 (Kollarova et al. 2009. Plant Science 177
324–330).
Additives with immuno-potentiating and antioxidant properties in food products and
pharmaceutical formulations.
MAN700
Galactoglucomannan polysaccharide
OH
OH
O
HO
OH
OH
OH
R
R
O
O
O
R
R
O
...O
R
O
OH
OH
O
O HO
R
OH O
O
O HO
O...
OH
n
R= -OAC or OH
68
n
On request
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OligoTech®
Alginate
Extraction from biomass
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OligoTech®
Algiinate
Extraction from biomass
STRUCTURAL DESCRIPTION
Alginic acid (algin, alginate) is a polysaccharide that is abundant in the cell walls of brown
algae. (Pheophyceae, mainly laminariales and fucales) and in specific bacteria (acetylated
form). Chemically, it is a linear copolymer with homopolymeric blocks of (1-4)-linked β-Dmannuronate (M) and its C-5 epimer α-L-guluronate (G) residues, respectively, covalently
linked together in different sequences or blocks.
The monomers can appear in homopolymeric blocks of consecutive G-residues (G-blocks),
consecutive M-residues (M-blocks), alternating M and G-residues (MG-blocks) or randomly
organized blocks.
OH
-
OOC
O
OH
G
O
OH
-
OOC
O
OH
-
OOC
G
O
OH
G
O
HO
HO
O
HOOC
O
OOC
O
OH
O
HO
HOOC
HO
O
O
HOOC
OH
M
OH
-
OH
O
HOOC
O
OH
HOOC
O
O
OH
M
M
G
OH
O
HO
M
OH
O
OH
HOOC
HO
OH
O
HO
M
O
OH
-
OOC
O
O
HO
O
OH
M
G
Chemical Structures of Alginate
POSSIBLE BIOMASS SOURCES
Fucus vesiculosus
Laminaria japonica
ACTIVITIES AND USES
Alginates are widely used as waterproofing and fireproofing fabrics, as a gelling agent, for
thickening drinks, ice cream and cosmetics, as a detoxifier that can absorb poisonous metals
from the blood, as food additives (E number from E400 to E405), healthcare products
(rheological properties)…
Alginates also show health benefits as dermal fibroblast Modulators and antitumoral as well.
Finally, the so called compounds are described as products intended for agriculture applications
(Courtois, Current Opinion in Microbiology, 2009, 12:261–273).
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Alginate
Extraction from biomass
ALG100
Alginate polysaccharides (from Laminaria japonica)
Sodium salt alginates extracted and purified from
brown seaweed Laminaria japonica
[9005-38-3]
1 g, 10 g, 100 g
ALG101
Alginate polysaccharides (from Fucus vesiculosus)
Sodium salt alginates extracted and purified from
brown seaweed Fucus vesiculosus
[9005-38-3]
1 g, 10 g, 100 g
ALG102
Alginate polysaccharides (from Ascophyllum nodosum)
Sodium salt alginates extracted and purified from
brown seaweed Ascophyllum nodosum
[9005-38-3]
1 g, 10 g, 100 g
ALG103
Alginate polysaccharides (from Chorda filum)
Sodium salt alginates extracted and purified from
brown seaweed Chorda filum
[9005-38-3]
1 g, 10 g, 100 g
ALG104
Alginate polysaccharides (from Durvillaea antarctica)
Sodium salt alginates extracted and purified from
brown seaweed Durvillaea antarctica
[9005-38-3]
1 g, 10 g, 100 g
ALG105
Alginate polysaccharides Kit
NEW
Individually
packaged
Sodium
salt
alginates
extracted and purified from 5 species of brown
seaweeds
Each proposed in 100 mg pack size
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Algiinate
Extraction from biomass
ALG300
Guluronate oligosaccharides DP20 (sodium salt)
Oligosaccharides prepared by α(1-4) linked L-guluronate block hydrolysis.
Sodium salt.
Average Degree of polymerization (DP):20.
OH
OH
-
OOC
O
OH
O
OH
-
G
OOC
O
OH
O
n
OH
-
OOC
O
OH
M/G ratio<0.25
ALG310
O
OH
100 mg, 1 g, 10 g
Guluronate oligosaccharides DP10 (sodium salt)
Oligosaccharides prepared by α(1-4) linked L-guluronate block hydrolysis.
Sodium salt.
Average Degree of polymerization (DP): 10.
M/G ratio<0.25
ALG320
10 mg, 100 mg, 1 g
Guluronate oligosaccharides DP5 (sodium salt)
Oligosaccharides prepared by α(1-4) linked L-guluronate block hydrolysis.
Sodium salt.
Average Degree of polymerization (DP): 5.
M/G ratio<0.25
ALG330
10 mg, 100 mg, 1 g
Guluronate oligosaccharides DP3 (sodium salt)
Oligosaccharides prepared by α(1-4) linked L-guluronate block hydrolysis.
Sodium salt.
Average Degree of polymerization (DP): 3.
M/G ratio<0.30
10 mg, 100 mg, 1 g
Please contact us for custom oligosaccharide length and grade tailored to your need
Lower or higher M/G ratio can be obtained on demand
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Algiinate
Extraction from biomass
ALG500
Mannuronate oligosaccharides DP20 (sodium salt)
Oligosaccharides prepared by β(1-4) linked D-mannuronate block hydrolysis.
Sodium salt.
Average Degree of polymerization (DP): 20.
M
-
OOC
O
HO
O
-
O
OOC
OH
HO
OH
O
HO
O
O
O
-
OOC
n
OH
M/G ratio>4
100 mg, 1 g, 10 g
ALG510
Mannuronate oligosaccharides DP10 (sodium salt)
Oligosaccharides prepared by β(1-4) linked D-mannuronate block hydrolysis.
Sodium salt.
Average Degree of polymerization (DP): 10.
M/G ratio>4
ALG520
10 mg, 100 mg, 1 g
Mannuronate oligosaccharides DP5 (sodium salt)
Oligosaccharides prepared by β(1-4) linked D-mannuronate block hydrolysis.
Sodium salt.
Average Degree of polymerization (DP): 5.
M/G ratio>4
ALG530
10 mg, 100 mg, 1 g
Mannuronate oligosaccharides DP3 (sodium salt)
Oligosaccharides prepared by β(1-4) linked D-mannuronate block hydrolysis.
Sodium salt.
Average Degree of polymerization (DP): 3.
M/G ratio>4
10 mg, 100 mg, 1 g
Please contact us for custom oligosaccharide length and grade tailored to your need
Lower or higher M/G ratio can be obtained on demand
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OligoTech®
Galacturronan / Apiogalacturonan
Extraction from biomass
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Galacturonan / Apiogalacturonan
Extraction from biomass
STRUCTURAL DESCRIPTION
Pectic polysaccharides are a major part of the plant cell wall. They form a network
independent from the hemicellulose/cellulose network and influence cell wall properties such
as porosity or tensile strength. Pectins consist of three major structural elements:
galacturonan, which is a linear chain of α(1-4)-linked D-galacturonic acids,
rhamnogalacturonan I, which consists of a back bone of altering α-1,4-linked galacturonic
acid and α(1-2)-linked rhamnose units and the complex rhamnogalacturonan II (RG II). RG
II is a well-defined structural element of pectin. It is of low molecular weight. Its 12 different
sugars are connected via 20 different linkages. Attached to a backbone of 8–10 galacturonic
acid residues rhamnogalacturonan II contains four side chains with rare and therefore
diagnostic sugars: 2-O-methyl fucose, 2-O-methyl xylose, apiose, 3-C-carboxy-5-deoxy-Lxylose (aceric acid), 3-deoxy-D-lyxo-2-heptulosaric acid (DHA), and 3-deoxy-D-manno-2octulosonic acid (KDO).
Apiogalacturonans are present in the walls of some aquatic monocots including Lemna
minor and Zostera marina. The backbone is mainly made of α(1-4) linked D-galacturonic acid
substituted with single β-D-Apiose and β-D-Apiose-(1-5)-β-D-Apiose side chains at C2/C3
position. In the ramified region of the macromolecule, Arabinose, galactose, xylose and O-MeXylose are possible minor components of side chains.
POSSIBLE BIOMASS SOURCES
Apple Pectin
Lemon Pectin
Zostera marina (Apiogalacturonan)
ACTIVITIES AND USES
The main use for galacturonan (pectin) is as a gelling agent, thickening agent and stabilizer
in food. They have shown prebiotic activities as dietary fibers, anti-angiogenic and
immunomodulatory activities.
Oligogalacturonides (OGA) prepared by homogalacturonan hydrolysis (either by chemical
or enzymatic):
x Induce reponse involved in plant defenses (B.L. Ridley et al., 2001. Phytochem., 57; 929–
967)
x Have bifidogenic, prebiotic properties, inhibit the adherence of bacteria to epithelial
cells, the initial and crucial stage of infection. (DP2-DP7)
x Stimulate the apoptosis of colon cancer cells
x Might implicate an additional mechanism of immunologic protection provided by human
milk of the infants (Vos, A. P., Stahl, B., et al. 2007 Pediatric Allergy and Immuno., 18, 304312)
Apiogalacturonan are used as ingredient intended for skin care.
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Galacturonan / Apiogalacturonan
Extraction from biomass
GAT100
Galacturonate polysaccharides LM from apple (sodium salt)
Low methylated α(1-4) linked D-galacturonate extracted and
purified from apple pectins. Sodium salt.
Degree of esterification (DE)<5%.
HO
HO
O
O
O
OH
-
OOC
O
OH
-
OOC
-
OH
O
-
OOC
OOC
OH
O
O
O
HO
GAT101
[25990-10-7]
O
HO
1 g, 10 g, 100 g
Galacturonate polysaccharides HM from apple (sodium salt)
High methylated α(1-4) linked D-galacturonate extracted and
purified from apple pectins.
Degree of esterification (DE)>70%.
HO
HO
O
O
O
OH
MeOOC
O
GAT102
O
OH MeOOC
-
OOC
OH MeOOC
O
O
HO
[9000-69-5]
OH
O
O
HO
1 g, 10 g, 100 g
Galacturonate polysaccharides LM from citrus (sodium salt)
Low methylated α(1-4) linked D-galacturonate extracted and
purified from apple pectins. Sodium salt.
Degree of esterification (DE)<5%.
HO
HO
O
O
O
OH
-
OOC
O
OH
-
OOC
-
OH
O
OOC
-
OOC
OH
O
O
HO
GAT103
[9049-37-0]
O
O
HO
1 g, 10 g, 100 g
Galacturonate polysaccharides HM from citrus (sodium salt)
High methylated α(1-4) linked D-galacturonate extracted and
purified from citrus pectins. Sodium salt.
Degree of esterification (DE)>65%.
HO
HO
O
O
O
MeOOC
O
HO
OH
[9046-40-6]
-
OOC
OH MeOOC
O
O
HO
O
OH MeOOC
OH
O
O
1 g, 10 g, 100 g
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OligoTech®
Galacturonan / Apiogalacturonan
Extraction from biomass
GAT200
Apiogalacturonan polysaccharide (sodium salt)
Apiogalacturonan polysaccharide is extracted and purified from Zostera marina.
OH
HO
CH2OH
HO
O
O
HO
O
O
O
OH
-
-
OOC
O
OOC
-
O
O
OOC
-
OOC
OH
O
O
O
HO
O
O
HO
O
O
CH2OH
HO
HO
GAT300
OH
OH
10 mg, 100 mg, 1 g
Rhamnogalacturonan polysaccharide from gombo (sodium salt)
Acetylated and galactose branched Rhamnogalaturonate polysaccharide
extracted and purified from Gombo or Okra (Abelmoschus esculentus).
10 mg, 100 mg, 1 g
GAT110
Galacturonan oligosaccharide block (OGAs)
α(1-4) linked D-galacturonate oligosaccharides with mixed DP prepared by low
methylated galacturonate polysaccharide hydrolysis. Sodium salt.
Average observed DP: 25
100 mg, 1 g, 10 g
GAT111
Galacturonan oligosaccharides Mixture DP3/DP4
α(1-4) linked D-galacturonate oligosaccharides with mixed DP3/DP4 prepared
by galacturonate polysaccharide hydrolysis. Sodium salt.
HPAEC>99% galacturonic acid
10 mg, 100 mg, 1g
GAT112
Galacturonan oligosaccharides Mixture DP7/DP8
α(1-4) linked D-galacturonate oligosaccharides with mixed DP7/DP8 prepared
by galacturonate polysaccharide hydrolysis. Sodium salt.
HPAEC>99% galacturonic acid
10 mg, 100 mg, 1g
Please contact us for custom oligosaccharide length and grade tailored to your need
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OligoTech®
Arabinan
Extraction from biomass
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OligoTech®
Arabinan
Extraction from biomass
STRUCTURAL DESCRIPTION
The L-arabinose-rich polysaccharides are named arabinans. So called polymers have a main
structure of α(1-5)-linked L-arabinofuranose units, substituted at either O-2 or O-3 or at both
of these positions.
Arabinans are side chains of the complex rhamnogalacturonan I found in the hemicellulosic
part of dicotyledonous cell walls also called pectins.
Arabinans can also be found as a minor component of the mycobacterial cell walls. In this
peculiar case, arabinan glycosidic linkages are α(1-3), α(1-5) and β(1-2) and branched the
microbial galactan.
POSSIBLE BIOMASS SOURCES
Apple Pomace
Olive pomace
Sugar beet
ACTIVITIES AND USES
Arabinans were found to be immunobiological active compounds (F. Dourado et al., 2004.
Carbohydrate Research 339; 2555–2566) and have hypoglycemic properties. Used as
Prebiotic/dietary fibers.
ARB105
Arabinan polysaccharides from Apple
Linear Arabinan polysaccharide extracted and purified from apple pomace.
The polysaccharide is an α(1-5) linked L-arabinose homopolymer.
Arabinose content (HPAEC)>99%
O
O...
OH
O
O
OH
OH
...O
80
OH
n
1 g, 10 g, 100 g
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OligoTech®
Fructan
Extraction from biomass
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Inulin
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OligoTech®
Fructan
Inulin
Extraction from biomass
STRUCTURAL DESCRIPTION
Some plants store carbohydrates in the form of inulin as an alternative, or in addition, to
starch. Inulins are composed of β(2-1) linked fructose units having a typical terminal glucose.
Native inulin encompasses a family of linear structures varying in degree of polymerization
(DP) from 3 to 60 (average DP=10). Oligofructose is obtained by partial hydrolysis of inulin
and has a small DP ranging from 2 to 8 (average DP=4). Oligofructose nomenclature is given
by the formula GFn (Glucose and Fructose number).
POSSIBLE BIOMASS SOURCES
Inulins are present in many vegetables and fruits, including onions, leeks, garlic, bananas,
asparagus, chicory, and Jerusalem artichokes.
Common chicory
Jerusalem artichoke
ACTIVITIES AND USES
This polymer is a recognised source for the production of either ultra-high fructose or
oligofructose syrups. Hence, Fructan are widely used in Agrofood industry. Inulin and
oligofructose are used to replace fat or sugar and reduce the calories of foods like ice cream,
dairy products, confections and baked goods
Oligofructose (FOs) is a prebiotic, and its positive effect on human health has been widely
acknowledged (e.g. osteoporosis). Oligofructose has approximately 30 to 50 percent of the
sweetness of table sugar. Inulin is less soluble than oligofructose and has a smooth creamy
texture that provides a fat-like mouthfeel.
Æ Recommended papers:
x
x
82
Kaur et al., Applications of inulin and oligofructose in health and nutrition, Journal of
Bioscience, 27 (2002), pp. 703–714.
D. Bosscher et al., 2006. International Dairy Journal, 16, 1092–1097.
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OligoTech®
Fructan
Inulin
Extraction from biomass
FRU100
Inulin from chicory roots
Fruβ(2-1)-[Fruβ(2-1)]35-α(2-1)Glc.
[9005-80-5]
Inulin extracted and purified from chicory roots
1 g, 10 g, 100 g
FRU110
Fructo-oligosaccharides mixture from Jerusalem artichoke (Cut-off<
10 kDa)
Fructo-oligosaccharides prepared by inulin hydrolysis
Purified by 10 kDa cut-off Ultrafiltration
100 mg, 1 g, 10 g
FRU101
1-kestose (DP3)
GF2
Fruβ(2-1)-Fruα(2-1)-Glc
C18H32O16
FW 504.43
OH
[470-69-9]
O
HO
HO
OH
HOH2 C
O
O
HO
CH 2
OH
HOH 2 C
O
O
HO
OH
FRU102
CH 2OH
10 mg, 100 mg, 1 g
Nystose (DP4)
GF3
Fruβ(2-1)-Fruβ(2-1)-Fruα(2-1)-Glc
C24H42O21
FW 666.57
[13133-07-8]
10 mg, 100 mg, 1 g
FRU111
Fructo-oligosaccharide DP5
GF4 / Fructofuranosyl-Nystose
Fruβ(2-1)-[Fruβ(2-1)]3-α(2-1)Glc
C30H52O26
FW 828.71
10 mg, 100 mg, 1 g
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OligoTech®
FRU112
Fructo-oligosaccharide DP6
GF5 / 1-F-(1-β-fructofuranosyl)-2-nystose
Fruβ(2-1)-[Fruβ(2-1)]4-α(2-1)Glc
C36H62O31
FW 990.85
10 mg, 100 mg, 1 g
FRU113
Fructo-oligosaccharide DP7
GF6 / 1-F-(1-β-fructofuranosyl)-3-nystose
Fruβ(2-1)-[Fruβ(2-1)]5-α(2-1)Glc
C42H72O36
FW 1152.99
10 mg, 100 mg, 1 g
FRU114
Fructo-oligosaccharide DP8
GF7
Fruβ(2-1)-[Fruβ(2-1)]6-α(2-1)Glc
C48H82O41
FW 1315.13
10 mg, 100 mg, 1 g
FRU115
Fructo-oligosaccharide DP9
GF8
Fruβ(2-1)-[Fruβ(2-1)]7-α(2-1)Glc
NEW
C54H92O46
FW 1477.27
10 mg, 100 mg, 1 g
FRU116
Fructo-oligosaccharide DP10
GF9
Fruβ(2-1)-[Fruβ(2-1)]8-α(2-1)Glc
NEW
C60H102O51
FW 1639.41
10 mg, 100 mg
FRU117
Fructo-oligosaccharide DP11
GF10
Fruβ(2-1)-[Fruβ(2-1)]9-α(2-1)Glc
NEW
C66H112O56
FW 1801.55
10 mg, 100 mg
FRU118
Fructo-oligosaccharide DP12
GF11
Fruβ(2-1)-[Fruβ(2-1)]10-α(2-1)Glc
NEW
C72H122O61
FW 1963.69
10 mg, 100 mg
FRU130
Fructo-Oligosaccharides Kit
Individually packaged Fructo-oligosaccharide kit from 1-kestose
(DP2) to Fructo-oligo GF9 (DP10).
NEW
84
Each proposed in 10 mg pack size
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OligoTech®
Spirulan
Extraction from biomass
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OligoTech®
Spirulan
Extraction from biomass
STRUCTURAL DESCRIPTION
Spirulan (mostly found in its calcium form) is an acidic sulfated polysaccharide extracted from
Spirulina (Arthrospira platensis) which is a multicellular, filamentous cyanobacterium,
belonging to a blue-green alga of Cyanobacteria.
Spirulan is a sulfated polysaccharide which consists of two types of disaccharide repeating
units, O-hexuronosylrhamnose (aldobiuronic acid) and O-rhamnosyl-3-O-methylrhamnose
(acofriose) with sulfate groups substituting rhamnose and O-methyl rhamnose at respectively
C2 and C4 position, other minor saccharides and sodium ions.
POSSIBLE BIOMASS SOURCES
Arthrospira platensis
ACTIVITIES AND USES
Spirulina contains much good-quality protein as well as carotenoids, vitamins, and minerals. It
has received attention as a most promising and highly nutritious food source (dietary
supplement). It has exhibited various biological activities such as lowering plasma cholesterol
levels and blood pressure.
Calcium Spirulan is a potent inhibitor of thrombin through heparin cofactor II (Y. Hayakawa
et al., 1997.Biochimica et Biophysica Acta 1355; 241–247) and is thought to enhance antiviral
and anti-coagulation effects (J.-B. Lee et al., 2007.Carbohydrate Polymers 69; 651–658).
Æ Recommended paper:
x
J. Yasuhara-Bell, Y. Lu., 2010. Antiviral Research, 86, 231–240.
SPR100
Spirulan polysaccharides Fine Grade
Spirulan polysaccharides are extracted and purified from Arthrospira
O...
platensis.
O
HO
O
HOOC
OR
O
O
MeO
O
OH
O
R= -O-SO 3-
O
HO
OR
O
HO
...O
86
HO
O
RO
OR
10 mg, 100 mg, 1 g
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OligoTech®
Heteroglycan
Extraction from biomass
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OligoTech®
Heteroglycan
Extraction from biomass
STRUCTURAL DESCRIPTION
Caulerpa racemosa is green seaweed of great interest since it has been highlighted antiviral
and biological activity evidences.
Extracts from Caulerpa racemosa contain two major polysaccharides which are α(1-4) glucan
and sulphated xyloarabinogalactan.
POSSIBLE BIOMASS SOURCES
Caulerpa racemosa
ACTIVITIES AND USES
Antiviral effects (Chattopadhyay et al., 2007. Carbohydrate Polymers, 68; 407–415).
HGL100
Sulfated heteropolysaccharides native grade
Sulfated heteropolysaccharides and beta glucan are extracted and purified
from Caulerpa racemosa
100 mg, 1 g, 10 g
HGL101
Sulfated heteropolysaccharides fine grade
Sulfated heteropolysaccharides are extracted from Caulerpa racemosa
and purified by Anion affinity.
Low Glucan content.
10 mg, 100 mg, 1 g
88
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OligoTech®
Glycan Oligosaccharides
Production by bacterial fermentation
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OligoTech®
90
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icityl-oligotech.com
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OligoTech®
Glycan oligosaccharides
Production by bacterial fermentation
The offer
x
Elicityl’s OligoTech® encompasses a collection of almost 200 glycan-type bioactive
oligosaccharides involved in key biological pathways (cell adhesion, immunological
recognition, embryogenesis, oncogenesis, infection…).
x
The collection comprises a large diversity of bioactive oligosaccharides such as
carbohydrate determinants of human blood groups (ABH, Lewis, P) and carbohydrate
portions of the major glycosphingolipids (gangliosides, globosides).
x
These oligosaccharides have numerous potential applications in different fields as anticancer vaccines, anti-infective, anti-neurodegenerative, diagnosis or functional food.
x
Elicityl also provides Glycobricks®, functionalized oligosaccharides which could be used as
elementary building blocks for click chemistry.
x
The products are available from the mg to the multi-gram scale.
Production
x
Elicityl produces all OligoTech® oligosaccharides in its own laboratories.
x
Elicityl develops industrial methods of production based on
oligosaccharide elaboration, purification and characterization.
x
Glycan-type bioactive oligosaccharides production is based on the “living factory process”,
a unique patented technology consisting in bacterial fermentation of metabolically
engineered strains.
its
expertise
in
Analysis and Quality Control
x
Elicityl develops standardized production processes in a QA/QC policy allowing
reproducibility and traceability of production batches.
x
The products supplied are consistent with internal standards. They are analysed by
adapted and efficient technologies such as HPLC, HPAEC, NMR & Mass spectrometries.
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OligoTech®
Glycan oligosaccharides
Production by bacterial fermentation
Something to know about our glycans
x Our glycans are the carbohydrate moiety of complex Glycosphingolipids
Our Glycans
Phosphosphingolipids
β1-3
β1-
Ceramide
GlcCer
β1β1-4
β1-3
β1-3
β1-3
α2-3
α2-3
β1-3
Galactose
α2-8
N-Acetyl
Galactosamine
α2-3
α2-3/6
α2-6
β1-6
α1-3
GalCer
Isoglobo-Series
α2-3
Globo-Series
Neo-Lacto-Series
Lacto-Series
α2-8
Ganglio-Series
Glucose
N-Acetyl
Glucosamine
N-Acetyl Neuraminic Acid /
Sialic Acid
• Modified from the Consortium for Functional Glycomics
• CFG nomenclature
http://www.functionalglycomics.org/static/consortium/Nomenclature.shtml
x Decrypting the Structure and Biosynthesis of Antigens : The main precursors
Type 1
Type 2
Type 3
Type 4
Type 5
β3
β1-R
β4
• Found in N- or O-glycoproteins
• Found in Glycolipids of the Lacto-Series
β1-R
β3
α1-R
• Only found in O-Glycans (Core 1 subtype)
β1-R
• Found in glycolipids of Globo-Series
• Found in glycolipids of Ganglio-Series
β1-R
• Free lactose or lactosyl ceramide
β3
β4
• Iso & Forssman antigens precursor
92
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OligoTech®
Glycan oligosaccharides
Core Structures
Production by bacterial fermentation
We offer a range of glycan from type 1, 2 & 4 core structures. Some of them, namely type 1 and 2
core structures are elementary building blocks for Human (HMO) and mammalian milk
oligosaccharides (HMO).
For more information please refer to our Human milk oligosaccharides (HMO) brochure.
Core structures type 1
GLY009
Lacto-N-Biose
Galβ1-3GlcNAc
OH
C14H25NO11
FW 383.35
[50787-09-2]
OH
OH
O
HO
HO
O
OH
O
NHAc
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY005
Core type 1 triaose
Galβ1-3GlcNAcβ1-3Gal
OH
O
HO
HO
OH
O
O
O
O
OH
NHAc
OH
GLY010
OH
OH
OH
C20H35NO16
FW 545.48
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Lacto-N-tetraose
LNT
Galβ1-3GlcNAcβ1-3Galβ1-4Glc
OH
OH
OH
O
HO
OH
HO
C26H45NO21
FW 707.62
OH
[14116-68-8]
OH
O
O
O
O
NHAc
Human Milk Oligosaccharide
Kunz et al., 2000. Ann Rev Nutr. 20, 699-722
OH
OH
OH
HO
O
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
GLY011
Lacto-N-Triaose
LNT2
GlcNAcβ1-3Galβ1-4Glc
OH
OH
C20H35NO16
FW 545.48
OH
O
HO
HO
OH
HO
O
O
NHAc
[75645-27-1]
OH
O
O
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Core structures type 4
GLY126
Core type 4
Gb5 Triaose core structure
Galβ1-3GalNAcβ1-3Gal
OH
OH
OH
C20H35NO16
FW 545.48
OH
OH
OH
O
O
O
O
O
HO
OH
OH
NHAc
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Core structures type 2
GLY008
N-Acetyl-D-Lactosamine
LacNAc
Galβ1-4GlcNAc
OH
C14H25NO11
FW 383.35
OH
[32181-59-2]
NHAc
O
HO
O
HO
OH
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY006
Core type 2 triaose
Galβ1-4GlcNAcβ1-3Gal
OH
OH
O
HO
OH
AcNH
HO
O
OH
OH
O
O
O
OH
C20H35NO16
FW 545.48
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
94
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OligoTech®
GLY021
Lacto-N-neotetraose
LNnT / neo-LNT
Galβ1-4GlcNAcβ1-3Galβ1-4Glc
OH
OH
AcNH
O
HO
O
HO
OH
OH
O
O
OH
OH
OH
OH
OH
Human Milk Oligosaccharide
Boehm et al., 2007 J Nutr Mar;137(3 Suppl 2):847S
GLY022
[13007-32-4]
O
O
HO
O
OH
C26H45NO21
FW 707.62
5 mg, 25 mg, 100 mg, 1 g, 5 g
Para-Lacto-N-neohexaose
Para-LNnH
Galβ1-4GlcNAcβ1-3Galβ1-4GlcNAcβ1-3Galβ1-4Glc
C40H68N2O31
FW 1072.96
[64331-48-2]
OH
OH
OH
O
HO
OH
AcNH
HO
O
OH
O
O
AcNH
HO
O
O
OH
O
OH
O
O
HO
O
OH
OH
Human Milk Oligosaccharide
Kunz et al., 2000. Ann Rev Nutr. 20, 699-722
GLY023
OH
OH
O
OH
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Lacto-N-neooctaose
LNnO
C54H91N3O41
FW 1438.29
Galβ1-4GlcNAcβ1-3Galβ1-4GlcNAcβ1-3Galβ1-4GlcNAcβ1-3Galβ1-4Glc
OH
OH
OH
AcNH
O
HO
O
HO
OH
O
OH
O
HO
O
OH
OH
AcNH
HO
O
O
O
HO
OH
Human Milk Oligosaccharide
Kunz et al., 2000. Ann Rev Nutr. 20, 699-722
O
OH
AcNH
HO
O
O
OH
OH
OH
O
O
OH
O
HO
OH
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
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O
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OligoTech®
Glycan oligosaccharides
Blood group and Lewis antigens
Production by bacterial fermentation
Product description
Histo-Blood groups antigens also called HBGs (A, B, H) and related antigens are complex
carbohydrates present on the surface of red blood cells and mucosal epithelium of the respiratory,
genitourinary and digestive tracks. They are also present as free oligosaccharides in biologic fluids
such as saliva, intestinal content, milk (HMO) and blood.
x Secretor phenotype (Se): ABH antigens are expressed along the oro-gastrointestinal
mucosal of individuals of positive secretor status. Se individuals express the Secretor-fucosyl
transferase FUT2 producing the H antigen.
x Non secretor phenotype (Se0): Individuals of non secretor phenotype lack the
secretor-transferase and make shorter Lewisa antigen (Lea)
x Bombay phenotype: Individuals lack fucosylated ABH antigens on erythrocytes in
circulation (rare phenotype) due to mutation of FUT1 allele.
Sialyl type 1/ 2
Refer to GLY084-1 & 84-2 αST
FUT 3/4
α2-3
β3/4
Type 1/2
precursor
FUT2
Secretor
α2
α3/4
β3/4
H Type 1/2
β3/4
FUT3/4
Lewis Leb/y
A or B
enzymes
SialylLewis Le a/x
Non Secretor
α2
α2
α3
β3/4
A Type 1/2
α2
β3/4
B Type 1/2
FUT3/4
FUT3/4
α3
α3
α3/4
β3/4
ALeb/y
α2
α3
α3/4
β3/4
BLe b/y
Further readings:
x
x
x
96
Marionneau et al. 2001. ABH and Histo-blood Group antigens. Biochimie, 83; 565−573.
Tan et al. Norovirus and its HBGA receptors: an answer to historical puzzle. Trends in microbiology,
Vol.13 No.6 (2005)
For more information please refer to our HBGA blood group systems brochure
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OligoTech®
Blood group H antigens (Blood group O)
GLY030
Blood group H antigen disaccharide
Fucα1-2Gal
OH
C12H22O10
FW 326.29
OH
[16741-18-7]
[24656-24-4]
[146076-26-8]
O
OH
HO
O
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
HO OH
GLY031-1
Blood group H antigen triaose type 1
Fucα1-2Galβ1-3GlcNAc
OH
C20H35O15
FW 529.49
OH
OH
O
HO
HO
O
O
OH
NHAc
O
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
HO OH
GLY031-2
Blood group H antigen triaose type 2
Fucα1-2Galβ1-4GlcNAc
OH
OH
O
HO
C20H35O15
FW 529.49
AcNH
HO
O
O
OH
O
OH
O
OH
HO
GLY031-3
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Blood group H antigen triaose type 5
2’Fucosyllactose/ 2’FL
Fucα1-2Galβ1-4Glc
OH
OH
O
HO
O
OH
HO
O
C18H32O15
FW 488.43
OH
[41263-94-9]
O
OH
O
OH
HO OH
Human Milk Oligosaccharide
Kunz et al., 2000. Ann Rev Nutr. 20, 699-722
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
GLY032-1
Blood group H antigen tetraose type 1
Fucα1-2Galβ1-3GlcNAcβ1-3Gal
OH
OH
OH
O
HO
HO
C26H45NO20
FW 691.62
OH
OH
O
O
O
O
OH
NHAc
O
OH
O
OH
HO OH
GLY032-2
5 mg, 25 mg, 100 mg, 1 g, 5 g
Blood group H antigen tetraose type 2
Fucα1-2Galβ1-4GlcNAcβ1-3Gal
OH
OH
C26H45NO20
FW 691.62
AcNH
O
HO
O
HO
O
OH
OH
O
O
O
OH
OH
OH
O
OH
HO
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY127
Blood group H antigen tetraose type 4/ Globo H tetraose
Fucα1-2Galβ1-3GalNAcβ1-3Gal
OH
OH
OH
O
OH
OH
O
O
OH
O
O
HO
C26H45NO20
FW 691.62
OH
O
NHAc
OH
O
OH
HO OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY033-1
Blood group H antigen pentaose type 1
Lacto-N-fucopentaose I (LNFP I)
Fucα1-2Galβ1-3GlcNAcβ1-3Galβ1-4Glc
OH
OH
OH
OH
O
HO
HO
O
OH
O
O
O
O
C32H55NO25
FW 853.76
NHAc
OH
[7578-25-8]
OH
OH
HO
O
O
OH
O
OH
HO
OH
Human Milk Oligosaccharide
Kunz et al., 2000. Ann Rev Nutr. 20, 699-722
98
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
GLY033-2
Blood group H antigen pentaose type 2
Lacto-N-neofucopentaose I (LnNFP I)
Fucα1-2Galβ1-4GlcNAcβ1-3Galβ1-4Glc
OH
OH
AcNH
O
HO
O
HO
OH
OH
O
O
O
C32H55NO25
FW 853.76
O
OH
OH
O
HO
OH
O
OH
OH
O
OH
HO OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Blood group A antigens
GLY034
Blood group A antigen triaose
GalNAcα1-3(Fucα1-2)Gal
OH
C20H35NO15
FW 529.49
OH
[49777-13-1]
O
HO
OH
OH
O
AcHN
O
OH
O
O
OH
HO OH
GLY035-1
5 mg, 25 mg, 100 mg, 1 g, 5 g
Blood group A antigen tetraose type 1
GalNAcα1-3(Fucα1-2)Galβ1-3GlcNAc
OH
C28H48N2O20
FW 732.68
OH
O
HO
OH
AcHN
OH
OH
O
O
HO
O
O
OH
NHAc
O
O
OH
HO
GLY035-2
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Blood group A antigen tetraose type 2
GalNAcα1-3(Fucα1-2)Galβ1-4GlcNAc
OH OH
C28H48N2O20
FW 732.68
O
OH OH
HO
AcHN
O
O
O
O
HO OH
AcHN
HO
O
OH
O
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
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13/06/12 8:01:47
OligoTech®
GLY035-3
Blood group A antigen tetraose type 5
GalNAcα1-3(Fucα1-2)Galβ1-4Glc
OH
C26H45NO20
FW 691.62
OH
[59957-92-5]
O
HO
OH
OH
OH
O
AcHN
HO
O
O
OH
O
O
OH
O
OH
HO OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Blood group A Lewisb antigen pentaose type 1
GLY035-4
GalNAcα1-3(Fucα1-2)Galβ1-3(Fucα1-4)GlcNAc
OH
OH
OH
C34H58N2O24
FW 878.82
OH
HO
O
O
HO
OH
OH
OH
O
AcHN
O
O
O
O
OH
NHAc
O
O
OH
HO
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Blood group A LewisY antigen pentaose type 2
GLY035-5
GalNAcα1-3(Fucα1-2)Galβ1-4(Fucα1-3)GlcNAc
OH
OH OH
OH
HO
O
HO
O
AcHN
OH OH
O
AcHN
O
O
O
O
OH
O
O
OH
OH
HO OH
GLY036-1
C34H58N2O24
FW 878.82
5 mg, 25 mg, 100 mg, 1 g, 5 g
Blood group A antigen pentaose type 1
GalNAcα1-3(Fucα1-2)Galβ1-3GlcNAcβ1-3Gal
OH
C34H58N2O25
FW 894.82
[50624-46-9]
OH
O
HO
OH
OH
OH
O
AcHN
O
HO
O
OH
O
OH
O
O
O
NHAc
OH
OH
O
OH
HO OH
100
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
GLY036-2
Blood group A antigen pentaose type 2
GalNAcα1-3(Fucα1-2)Galβ1-4GlcNAcβ1-3Gal
OH
C34H58N2O25
FW 894.82
OH
O
OH
HO
OH
AcNH
O
AcHN
HO
O
O
OH
OH
O
O
O
O
OH
OH
OH
O
OH
OH
HO
GLY128
5 mg, 25 mg, 100 mg, 1 g, 5 g
Blood group A antigen pentaose type 4
GalNAcα1-3(Fucα1-2)Galβ1-3GalNAcβ1-3Gal
OH
C34H58N2O25
FW 894.82
OH
O
HO
OH
OH
OH
OH
OH
OH
O
O
AcHN
O
O
O
O
O
OH
NHAc
OH
O
OH
OH
HO
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY037-1
Blood group A antigen hexaose type 1
GalNAcα1-3(Fucα1-2)Galβ1-3GlcNAcβ1-3Galβ1-4Glc
OH
C40H68N2O30
FW 1056.96
OH
O
HO
OH
OH
OH
O
AcHN
O
HO
OH
OH
O
O
O
O
NHAc
O
OH
OH
HO
O
OH
O
OH
O
OH
HO OH
GLY037-2
5 mg, 25 mg, 100 mg, 1 g, 5 g
Blood group A antigen hexaose type 2
GalNAcα1-3(Fucα1-2)Galβ1-4GlcNAcβ1-3Galβ1-4Glc
OH
C40H68N2O30
FW 1056.96
OH
O
OH
HO
OH
O
AcHN
O
O
AcHN
HO
O
O
OH
OH
OH
O
O
OH
OH
O
HO
O
OH
OH
O
OH
HO OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
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13/06/12 8:01:47
OligoTech®
Blood group B antigens
GLY038-1
Blood group B antigen tetraose type 1
Galα1-3(Fucα1-2)Galβ1-3GlcNAc
OH
C26H45NO20
FW 691.62
OH
O
OH
HO
OH
OH
O
HO
HO
O
O
O
OH
NHAc
O
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
HO OH
GLY038-2
Blood group B antigen tetraose type 2
Galα1-3(Fucα1-2)Galβ1-4GlcNAc
OH
C26H45NO20
FW 691.62
OH
O
OH
HO
OH
OH
AcNH
O
HO
O
O
OH
O
O
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
HO OH
GLY038-3
Blood group B antigen tetraose type 5
Galα1-3(Fucα1-2)Galβ1-4Glc
OH
C24H42O20
FW 650.57
OH
O
OH
HO
OH
OH
O
OH
HO
O
O
OH
O
O
OH
O
OH
HO
GLY038-4
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Blood group B Lewisb antigen pentaose type 1
Galα1-3(Fucα1-2)Galβ1-3(Fucα1-4)GlcNAc
OH
OH
OH
C32H55NO24
FW 837.77
OH
HO
O
O
OH
HO
OH
OH
O
HO
O
O
O
O
O
OH
NHAc
O
OH
HO
102
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
GLY038-5
Blood group B LewisY antigen pentaose type 2
Galα1-3(Fucα1-2)Galβ1-4(Fucα1-3)GlcNAc
OH
OH
OH
HO
O
OH
HO
OH
OH
C32H55NO24
FW 837.77
OH
O
AcNH
O
O
OH
O
O
O
O
OH
O
OH
GLY039-1
5 mg, 25 mg, 100 mg, 1 g, 5 g
OH
HO
Blood group B antigen pentaose type 1
Galα1-3(Fucα1-2)Galβ1-3GlcNAcβ1-3Gal
OH
C32H55NO25
FW 853.76
OH
O
HO
OH
HO
OH
OH
O
O
HO
OH
O
O
O
O
OH
NHAc
O
OH
OH
O
OH
HO OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY039-2
Blood group B antigen pentaose type 2
Galα1-3(Fucα1-2)Galβ1-4GlcNAcβ1-3Gal
OH
C32H55NO25
FW 853.76
OH
O
OH
HO
OH
OH
O
O
O
AcNH
HO
O
OH
OH
O
O
O
OH
OH
OH
O
OH
HO
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
GLY129
Blood group B antigen pentaose type 4
Galα1-3(Fucα1-2)Galβ1-3GalNAcβ1-3Gal
OH
C32H55NO25
FW 853.76
OH
O
OH
HO
OH
OH
OH
OH
OH
OH
O
O
O
O
O
OH
O
O
OH
NHAc
O
OH
HO OH
GLY040-1
5 mg, 25 mg, 100 mg, 1 g, 5 g
Blood group B antigen hexaose type 1
Galα1-3(Fucα1-2)Galβ1-3GlcNAcβ1-3Galβ1-4Glc
OH
C38H65NO30
FW 1015.90
OH
O
HO
OH
OH
OH
O
HO
O
HO
OH
OH
O
OH
O
NHAc
O
OH
HO
O
O
O
O
OH
OH
O
OH
HO
GLY040-2
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Blood group B antigen hexaose type 2
Galα1-3(Fucα1-2)Galβ1-4GlcNAcβ1-3Galβ1-4Glc
OH
C38H65NO30
FW 1015.90
OH
O
OH
HO
OH
OH
O
O
O
AcNH
HO
O
O
O
OH
OH
OH
O
OH
OH
O
HO
O
OH
OH
O
OH
HO
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
104
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OligoTech®
Lewis antigens
GLY049
LewisX (LeX) triaose
SSEA-1 / CD15
Galβ1-4(Fucα1-3)GlcNAc
C20H35NO15
FW 529.49
OH
OH
[71208-06-5]
HO
O
OH
OH
AcNH
O
O
O
HO
OH
O
OH
GLY050
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
LewisX (LeX) tetraose
Galβ1-4(Fucα1-3)GlcNAcβ1-3Gal
C26H45NO20
FW 691.62
OH
OH
HO
O
OH
OH
AcNH
O
HO
O
O
OH
O
O
OH
GLY051
OH
O
OH
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
LewisX (LeX) hexaose
Lacto-N-neodifucohexaose (LNnDFH)
Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ1-4(Fucα1-3)Glc
OH
C38H65NO29
FW 999.90
OH
HO
O
OH
O
OH
AcNH
O
O
HO
OH
O
O
O
OH
OH
OH
O
OH
O
OH
OH
O
OH
O
OH
HO OH
Human Milk Oligosaccharide
Kunz et al., 2000. Ann Rev Nutr. 20, 699-722
Product provided for the following study :
“Structural basis for the interaction between human
milk oligosaccharide and the bacterial lectin PA-IIL of
Pseudomonas aeruginosa”
Perret S et al., 2005. Biochem J. Jul 15;389.
5 mg, 25 mg, 100 mg, 1 g, 5 g
www.elicityl-oligotech.com
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13/06/12 8:01:48
OligoTech®
GLY048
LewisY (LeY) tetraose
Fucα1-2Galβ1-4(Fucα1-3)GlcNAc
OH
C26H45NO19
FW 675.63
OH
[82993-43-9]
HO
O
OH
OH
AcNH
O
O
O
HO
OH
O
O
OH
O
OH
OH
HO
GLY052
5 mg, 25 mg, 100 mg, 1 g, 5 g
LewisY (LeY) pentaose
Fucα1-2Galβ1-4(Fucα1-3)GlcNAcβ1-3Gal
OH
C32H55NO24
FW 837.77
OH
HO
O
OH
OH
OH
AcNH
O
O
O
HO
O
OH
O
O
O
OH
OH
OH
O
OH
HO
GLY046
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Lewisa (Lea) triaose
Galβ1-3(Fucα1-4)GlcNAc
OH
HO
OH
[56570-03-7]
O
OH
OH
O
O
HO
O
O
OH
NHAc
OH
GLY054
C20H35NO15
FW 529.49
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Lewisa (Lea) tetraose
Galβ1-3(Fucα1-4)GlcNAcβ1-3Gal
OH
HO
OH
O
OH
OH
O
HO
OH
O
C26H45NO20
FW 837.77
OH
OH
O
O
OH
O
O
NHAc
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
106
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OligoTech®
GLY055
Lewisa (Lea) hexaose
Lacto-N-difucohexaose II (LNDFH II)
Galβ1-3(Fucα1-4)GlcNAcβ1-3Galβ1-4(Fucα1-3)Glc
OH
HO
OH
OH
O
OH
OH
O
HO
OH
OH
O
O
OH
O
O
O
NHAc
O
OH
OH
Human Milk Oligosaccharide
Kunz et al., 2000. Ann Rev Nutr. 20, 699-722
GLY045
[62258-12-2]
O
OH
O
O
OH
OH
OH
HO
C38H65NO29
FW 999.90
5 mg, 25 mg, 100 mg, 1 g, 5 g
Lewisb (Leb) tetraose
Fucα1-2Galβ1-3(Fucα1-4)GlcNAc
OH
HO
OH
C26H45NO19
FW 675.63
OH
[80081-06-7]
O
OH
OH
O
O
HO
O
O
OH
NHAc
O
O
OH
OH
HO
GLY056
5 mg, 25 mg, 100 mg, 1 g, 5 g
Lewisb (Leb) pentaose
Fucα1-2Galβ1-3(Fucα1-4)GlcNAcβ1-3Gal
OH
HO
OH
O
OH
OH
O
O
HO
C32H55NO24
FW 837.77
OH
OH
OH
O
O
O
O
OH
NHAc
O
OH
O
OH
HO OH
Receptor of gastric pathogenic strain
Becker DJ, Lowe JB. 2003. Glycobiology. Jul; 13(7): 41R53R
GLY047
5 mg, 25 mg, 100 mg, 1 g, 5 g
Sialyl LewisX (sLeX) tetraose
Sodium salt
Neu5Acα2-3Galβ1-4(Fucα1-3)GlcNAc
OH
C31H51N2O23Na
FW 842.72
OH
[98603-84-0]
HO
O
HOOC
OH
HO
O
HO
AcHN
OH
OH
OH
AcNH
O
O
OH
O
O
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
GLY053
Sialyl LewisX (sLeX) pentaose
Sodium salt
Neu5Acα2-3Galβ1-4(Fucα1-3)GlcNAcβ1-3Gal
OH
C37H61N2O28Na
FW 1004.86
OH
HO
O
HOOC
OH
HO
OH
AcNH
O
O
HO
AcHN
OH
O
O
O
OH
OH
Ligand of selectin-dependent leukocyte adhesion
Berg EL et al,. 1991. J Biol Chem. 266(23):14869-72
Tumor-associated-antigen (TACA)
Magnani JL. 1991. Glycobiology. Sep;1(4):318-20
GLY044
OH
O
O
OH
OH
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Sialyl Lewisa (sLea) tetraose
Sodium salt
Neu5Acα2-3Galβ1-3(Fucα1-4)GlcNAc
OH
C31H51N2O23Na
FW 842.73
OH
[92448-22-1]
HO
O
HOOC
OH
HO
O
HO
AcHN
OH
108
OH
OH
OH
O
O
OH
O
O
OH
O
NHAc
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
Glycan oligosaccharides
Fucosylated oligosaccharides
Production by bacterial fermentation
Lacto-Series
GLY060
3 Fucosyllactose
3-FL
Galβ1-4(Fucα1-3)Glc
OH
C18H32O15
FW 488.43
OH
[41312-47-4]
HO
Human Milk Oligosaccharide
Kunz et al., 2000. Ann Rev Nutr. 20, 699-722.
O
OH
OH
OH
O
HO
Product provided for the following study :
“Structural basis for the interaction between
human milk oligosaccharide and the bacterial
lectin PA-IIL of Pseudomonas aeruginosa”
Perret S et al., 2005. Biochem J. Jul 15;389
OH
O
O
O
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY066
Lactodifucotetraose
Difucosyllactose / DF-L
Fucα1-2Galβ1-4(Fucα1-3)Glc
OH
HO
OH
C24H42O19
FW 634.57
OH
[20768-11-0]
Human Milk Oligosaccharide
Kunz et al., 2000. Ann Rev Nutr. 20, 699722.
O
OH
OH
O
OH
O
O
HO
O
O
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
HO OH
GLY063
3’Sialyl-3Fucosyllactose
F-SL
Sodium salt
Neu5Acα2-3Galβ1-4(Fucα1-3)Glc
OH
C29H48NO23Na
FW 801.67
OH
HO
O
HOOC
OH
HO
O
HO
AcHN
OH
OH
OH
OH
O
O
OH
Human Milk Oligosaccharide
Kunz et al., 2000. Ann Rev Nutr. 20, 699-722.
OH
O
O
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
GLY061
Lacto-N-neofucopentaose
LNnFP-V/LNFP VI
Galβ1-4GlcNAcβ1-3Galβ1-4(Fucα1-3)Glc
OH
OH
AcNH
O
HO
HO
O
OH
OH
O
O
OH
OH
OH
OH
OH
O
Human milk oligosaccharide
Kunz et al., 2000. Ann Rev Nutr. 20, 699OH 722.
Rosenstein et al., 1992. Infect. Immun.
60:5078-5084.
O
O
O
O
OH
C32H55NO25
FW 853.76
Product provided for the following
study :
Perret S et al., 2005. Biochem J. Jul 15;389.
OH
HO
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY062
Lacto-N-fucopentaose V
LNFP V
Galβ1-3GlcNAcβ1-3Galβ1-4(Fucα1-3)Glc
OH OH
HO
OH
OH
OH
OH
O
HO
HO
OH
O
NHAc
OH
OH
O
O
O
O
[60254-64-0]
O
OH
O
C32H55NO25
FW 853.76
OH
O
OH
Human Milk Oligosaccharide
Kunz et al., 2000. Ann Rev Nutr. 20, 699-722.
5 mg, 25 mg, 100 mg, 1 g, 5 g
“3-Fucosyllactose core” Oligosaccharides
GLY064
α1-3Galactosyl-3Fucosyllactose
Galα1-3Galβ1-4(Fucα1-3)Glc
OH
OH
C24H42O20
FW 650.57
OH
HO
OH
O
O
OH
HO
HO
OH
OH
O
O
OH
OH
O
O
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
110
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OligoTech®
GLY065
α1-4Gal-3Fucosyllactose
Galα1-4Galβ1-4(Fucα1-3)Glc
OH
C24H42O20
FW 650.57
OH
O
OH
HO
HO
OH
O
HO
OH
O
OH
O
OH
O
O
HO
O
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY067
3-Fucosylated Blood group A tetraose
GalNAcα1-3(Fucα1-2)Galβ1-4(Fucα1-3)Glc
OH
OH
OH
C32H55NO24
FW 837.77
OH
HO
O
O
OH
HO
OH
OH
O
AcHN
O
O
OH
O
O
O
OH
O
OH
HO OH
GLY068
5 mg, 25 mg, 100 mg, 1 g, 5 g
3-Fucosylated Blood group B tetraose
Galα1-3(Fucα1-2)Galβ1-4(Fucα1-3)Glc
OH
OH
OH
C30H52O24
FW 796.71
OH
HO
O
O
OH
HO
OH
OH
O
OH
O
O
O
O
OH
O
OH
O
OH
HO OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
Glycan oligosaccharides
Galα-3Gal oligosaccharides
Production by bacterial fermentation
Xeno and Galili antigens are major antigens responsible for the hyperacute rejection and identified
as α-galactosyl epitopes. The first one identified was the Linear-B trisaccharide (Galili et al. 1985,
1987) namely Galα1-3Galβ1-4GlcNAc.
α-Gal epitopes are abundantly expressed on cells of non-primate mammals and new world
monkeys whereas humans, apes and old world monkeys lack this epitope but produce against it
large amounts of antibodies anti-Gal. This interaction between them is of major clinical significance
causing rejection of pig organ transplants in human and monkeys (Zhao Chun chen et al.,
Glycobiology,vol.11, 2001).
Further Reading(s): Caroline Gebus et al. Carbohydrate research, 2012.
Galili & Xeno antigens
GLY074-1
Xeno antigen type 1
Galα1-3Galβ1-3GlcNAc
OH
C20H35NO16
FW 545.48
OH
O
HO
OH
OH
OH
OH
O
O
HO
O
OH
O
OH
GLY074-2
5 mg, 25 mg, 100 mg, 1 g, 5 g
NHAc
Xeno antigen type 2
Galili antigen triaose/Galα-3 epitope/Linear B-2 trisaccharide
Galα1-3Galβ1-4GlcNAc
OH
C20H35NO16
FW 545.48
OH
O
OH
HO
OH
OH
NHAc
O
OH
HO
O
O
O
OH
OH
Major porcine antigen responsible for xenograft
rejection. Sarkar et al., Carbohydrate Research. 1992.
233 245-50.
Ligand for Bovine Norovirus Newbury2 Expected to
Prevent Cross-Species Transmission. Zakhour M, et al.
(2009) PLoS Pathog 5(7): e1000504.
GLY071
5 mg, 25 mg, 100 mg, 1 g, 5 g
Galili antigen pentaose
Galα1-3Galβ1-4GlcNAcβ1-3Galβ1-4Glc
OH
C32H55NO26
FW 869.76
OH
O
HO
OH
OH
OH
O
O
OH
AcNH
HO
O
O
OH
OH
OH
O
O
OH
OH
O
HO
O
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
112
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OligoTech®
GLY077
Galili antigen heptaose
Galα1-3[Galβ1-4GlcNAcβ1-3]2Galβ1-4Glc
OH
C46H78N2O36
FW 1235.09
OH
O
HO
OH
OH
OH
AcNH
O
HO
O
O
O
OH
O
OH
O
O
HO
OH
OH
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
2
GLY078
OH
OH
O
Galili antigen nonaose
Galα1-3[Galβ1-4GlcNAcβ1-3]3Galβ1-4Glc
OH
C60H101N3O46
FW 1600.42
OH
O
HO
OH
OH
OH
AcNH
O
HO
O
O
O
OH
O
HO
O
OH
OH
OH
O
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
3
GLY079
OH
OH
O
Galili antigen undecaose
Galα1-3[Galβ1-4GlcNAcβ1-3]4Galβ1-4Glc
OH
C74H124N4O56
FW 1964.76
OH
O
HO
OH
OH
OH
AcNH
O
HO
O
O
O
OH
O
OH
OH
OH
O
HO
O
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
4
GLY075
OH
OH
O
Xeno lewisX / α-Gal-LewisX
Galα1-3Galβ1-4(Fucα1-3)GlcNAc
OH
OH
OH
OH
HO
O
OH
HO
OH
C26H45NO20
FW 691.62
O
OH
NHAc
O
O
O
OH
O
O
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Xeno Lewisa / α-Gal-Lewisa
GLY076
Galα1-3Galβ1-3(Fucα1-4)GlcNAc
OH
OH
OH
HO
O
HO
OH
OH
C26H45NO20
FW 691.62
OH
O
OH
OH
O
O
O
O
O
OH
OH
NHAc
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
Isoglobo-Series
GLY070
Isoglobotriaose
iGb3/ linear B-6 trisaccharide
Galα1-3Galβ1-4Glc
OH
C18H32O16
FW 504.43
OH
[56038-36-9]
O
OH
HO
OH
OH
O
OH
OH
HO
O
O
O
OH
GLY072
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Isoglobotetraose
iGb4 / Cytolipin R
GalNAcβ1-3Galα1-3Galβ1-4Glc
OH
OH
OH
C26H45NO21
FW 707.62
OH
O
[75645-26-0]
O
HO
OH
O
NHAc
OH
OH
OH
O
OH
HO
O
O
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY073
Isoglobopentaose / iGb5
Galβ1-3GalNAcβ1-3Galα1-3Galβ1-4Glc
OH
OH
OH
O
OH
OH
O
O
HO
O
OH
O
NHAc
OH
C32H55NO26
FW 869.76
OH
OH
OH
O
O
OH
OH
HO
O
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY134
Isoforssman antigen pentaose
GalNAcα1-3GalNAcβ1-3Galα1-3Galβ1-4Glc
OH
C34H58N2O26
FW 910.82
OH
O
OH
HO
NHAc
O
OH
OH
O
OH
O
O
NHAc
OH
OH
O
OH
O
OH
OH
HO
O
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
114
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OligoTech®
Glycan oligosaccharides
Sialylated oligosaccharides
Production by bacterial fermentation
Type 1
GLY084-1
Sialylated triaose type 1
Sialyl Lea precursor
Sodium salt
Neu5Acα2-3Galβ1-3GlcNAc
C25H41N2O19Na
FW 696.58
HOOC
OH
HO
OH
OH
OH
O
O
HO
AcHN
HO
O
OH
O
OH
O
NHAc
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY080
Sialylated tetraose type 1
Sodium salt
Neu5Acα2-3Galβ1-3GlcNAcβ1-3Gal
HOOC
OH
HO
OH
HO
O
OH
GLY085-1
OH
OH
O
O
HO
AcHN
C31H51N2O24Na
FW 858.72
OH
OH
O
O
O
O
OH
NHAc
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Disialylated tetraose type 1
Sodium salt
NeuAcα2-8Neu5Acα2-3Galβ1-3GlcNAc
C36H57N3O27Na2
FW 1009.81
HOOC
OH
HO
O
HO
AcHN
OH
HOOC
O
OH
HO
O
O
OH
GLY086-1
OH
OH
O
HO
AcHN
HO
O
O
OH
NHAc
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Trisialylated pentaose type 1
Sodium salt
NeuAcα2-8NeuAcα2-8Neu5Acα2-3Galβ1-3GlcNAc
C47H73N4O35Na3
FW 1323.05
HOOC
OH
HO
O
HO
AcHN
OH
O
HO
HO
AcHN
HOOC
O
OH HO
HOOC
O
OH
HO
AcHN
OH
OH
O
O
O
OH
OH
HO
O
OH
O
NHAc
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
GLY081
LS-Tetrasaccharide a (LSTa)
Sialyl-lacto-N-tetraose a
Sodium salt
Neu5Acα2-3Galβ1-3GlcNAcβ1-3Galβ1-4Glc
C37H61N2O29Na
FW 1020.86
[64003-58-5]
HOOC
OH
HO
OH
OH
OH
O
O
HO
AcHN
OH
O
OH
HO
O
O
OH
O
NHAc
OH
OH
HO
O
O
O
OH
Human milk oligosaccharide
Kunz et al., 2000. Ann Rev Nutr. 20, 699-722
GLY172
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Disialylated pentaose type 1
Sodium salt
NeuAcα2-8Neu5Acα2-3Galβ1-3GlcNAcβ1-3Gal
HOOC
OH
HO
HO
AcHN
C42H67N3O32Na2
FW 1171.95
O
OHHO
HOOC
O
O
HO
AcHN
OH
O
O
HO
OH
O
O
O
O
OH
OH
OH
OH
OH
OH
NHAc
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Type 2
GLY084-2
Sialylated triaose type 2
3’-α-sialyl-N-Acetyl-Lactosamine/ Sialyl Le
Sodium salt
x
precursor
Neu5Acα2-3Galβ1-4GlcNAc
HOOC
OH
HO
OH
C25H41N2O19Na
FW 696.58
OH
O
O
HO
AcHN
O
OH
OH
[81693-22-3]
NHAc
HO
O
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY082
Sialylated tetraose type 2
Sodium salt
Neu5Acα2-3Galβ1-4GlcNAcβ1-3Gal
HOOC
OH
HO
O
HO
AcHN
OH
OH
C31H51N2O24Na
FW 858.72
OH
O
O
OH
AcNH
OH
O
HO
O
OH
O
O
OH
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
116
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OligoTech®
GLY085-2
Disialylated tetraose type 2
Sodium salt
NeuAcα2-8Neu5Acα2-3Galβ1-4GlcNAc
C36H57N3O27Na2
FW 1009.81
HOOC
OH
HO
O
HO
AcHN
OH
HOOC
O
HO
OH
OH
NHAc
O
O
HO
AcHN
HO
O
O
OH
O
OH
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY086-2
Trisialylated pentaose type 2
Sodium salt
NeuAcα2-8NeuAcα2-8Neu5Acα2-3Galβ1-4GlcNAc
C47H73N4O35Na3
FW 1323.05
HOOC
OH
HO
O
HO
AcHN
OH
HOOC
O
HO
O
HO
AcHN
HOOC
O
OH HO
OH
OH
NHAc
O
O
HO
AcHN
HO
O
O
OH
OH
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY083
LS-Tetrasaccharide d (LSTd)
Sialyl-lacto-N-tetraose d
Sodium salt
Neu5Acα2-3Galβ1-4GlcNAcβ1-3Galβ1-4Glc
C37H61N2O29Na
FW 1020.86
[100789-83-1]
OH
HOOC
OH
HO
OH
O
O
HO
AcHN
OH
OH
O
OH
O
HO
O
NHAc
OH
OH
O
O
HO
OH
O
OH
O
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
Glycan oligosaccharides
Ganglioside sugars (Ganglio-Series)
Production by bacterial fermentation
Product description
Gangliosides are complex glycosphingolipids (abbreviated GSL and also called glycolipids) that
contain a sialic acid. They are buildings blocks of cell membrane of vertebrates and play key roles
in cell to cell and cell to extracellular matrix communication (receptors for toxin, hormone, virus…)
As part of tumor pathogenesis, these molecules are proposed as vaccine targets.
Ganglioside sugar Nomenclature:
x G stands for Ganglioside
x M, D, T & Q stands for mono, di, tri, quadri number of sialic acids
x 1, 2 3 as the order of distance migration in thin layer chromatography
GQ3
α8
α8
α3
β4
c-series
Gangliosides
GT2
GT1c
GQ1c
GD2
GD1b
GT1b
GT3
α8
α3
β4
b-series
Gangliosides
GD3
α3
β4
a-series
Gangliosides
GM3
β4
GM2
GM1a
GD1a
GT1a
β3
β4
β4
β4
β4
GM1b
GD1c
Modified from Essentials of Glycobiology 2nd Edition
GlcCer LacCer
x
x
x
118
GA2
GA1
Varki A, Cummings RD, Esko JD, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009.
Further readings:
J. Heimburg-Molinaro et al., Vaccine 29 (2011) 8802-8826.
S. Hakomori. Biochimica etBiophysica Acta 1780 (2008) 325-346.
For more information please refer to our Tumor-associated carbohydrate antigens
(TACA) brochure
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OligoTech®
GLY090
GM3 Ganglioside sugar
3'Sialyllactose
Sodium salt
Neu5Acα2-3Galβ1-4Glc
HOOC
OH
HO
OH
OH
OH
O
O
HO
AcHN
HO
O
O
[35890-38-1]
OH
O
OH
OH
C23H38NO19Na
FW 655.53
OH
Human Milk Oligosaccharide
Kunz et al., 2000. Ann Rev Nutr 20, 699-722
Product provided for the following study:
“Chemoenzymatic
synthesis
of
GM3
and
GM2
gangliosides
containing
a
truncated
ceramide
functionalized for glycoconjugate synthesis and solid
phase applications”. Jacques S et al,. 2006. Org Biomol
Chem. 2006 Jan 7;4(1):142-54
GLY091
100 mg, 1 g, 5 g
GD3 Ganglioside sugar
Disialyl lactose / DS-L
Sodium salt
Neu5Acα2-8Neu5Acα2-3Galβ1-4Glc
HO
HO
AcHN
C34H54N2O27Na2
FW 968.76
HOOC
OH
O
HOOC
O
OH HO
OH
OH
OH
O
O
HO
AcHN
HO
O
O
OH
OH
OH
Tumor-associated carbohydrate antigen (TACA)
Birkle S et al. 2003. Biochimie. 85(3-4): 455-63
Bovine Milk & Colostrum
P. K. Gopal et al. British Journal of Nutrition (2000), 84,
Suppl 1, S69-S74
GLY092
OH
O
5 mg, 25 mg, 100 mg, 1 g, 5 g
GT3 Ganglioside sugar
Trisialyl lactose
Sodium salt
Neu5Acα2-8Neu5Acβ2-8Neu5Acα2-3Galβ1-4Glc
C45H70N3O35Na3
FW 1282.00
HOOC
OH
HO
O
HO
AcHN
OH
HOOC
O
HO
HO
AcHN
O
HOOC
O
OHHO
OH
OH
OH
O
O
HO
AcHN
HO
O
O
OH
OH
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY105
GQ3 Ganglioside sugar
Quadrisialyl lactose
Sodium salt
C56H86N4O43Na4
FW 1595.23
Neu5Acα2-8Neu5Acα2-8Neu5Acβ2-8Neu5Acα2-3Galβ1-4Glc
OH
HO
HO
AcHN
HOOC
O
OH HO
HOOC
O
O
HO
AcHN
OH
HOOC
O
HO
O
HO
AcHN
OH
HOOC
O
HO
O
HO
AcHN
OH
OH
OH
O
O
OH
OH
HO
O
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
GLY093
GM2 Ganglioside sugar
Sodium salt
GalNAcβ1-4(Neu5Acα2-3)Galβ1-4Glc
C31H51N2O24Na
FW 858.72
HO
NHAc
HO
OH O
HOOC
OH
O
OH
HO
HO
AcHN
OH
O
O
OH
HO
O
O
O
OH
OH
OH
Tumor-associated carbohydrate antigen (TACA)
Birkle S et al. 2003. Biochimie. 85(3-4): 455-63
GLY094
5 mg, 25 mg, 100 mg, 1 g, 5 g
GD2 Ganglioside sugar
Sodium salt
GalNAcβ1-4(Neu5Acα2-8Neu5Acα2-3)Galβ1-4Glc
C42H67N3O32 Na2
FW 1171.95
HO
NHAc
HOOC
OH
HO
HO
O
HO
AcHN
OH O
HOOC
O
HO
OH
OH
OH
O
O
HO
AcHN
O
OH
OH
OH
HO
O
O
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY095
GT2 Ganglioside sugar
Sodium salt
C53H83N4O40 Na3
FW 1485.19
GalNAcβ1-4(Neu5Acα2-8Neu5Acα2-8Neu5Acα2-3)Galβ1-4Glc
HO
HOOC
OH
HO
O
HO
AcHN
OH
NHAc
HOOC
O
HO
HO
AcHN
O
OH HO
HO
OH O
O
HOOC
O
OH
O
O
HO
AcHN
O
OH
OH
OH
HO
O
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY096
GM1a Ganglioside sugar
Sodium salt
Galβ1-3GalNAcβ1-4(Neu5Acα2-3)Galβ1-4Glc
HO
[67063-78-9]
OH
HO
OH
O
O
NHAc
HO
OH
OH O
HOOC
O
OH
HO
O
HO
AcHN
OH
120
C37H61N2O29 Na
FW 1020.86
O
O
OH
OH
HO
O
OH
Product provided for this study:
“Solid phase immunoadsorption for
therapeutic and analytical studies on
neuropathy-associated
anti-GM1
antibodies”
Townson K et al,. Glycobiology. 2007
Mar;17(3):294-303
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
GLY097
GM1b Ganglioside sugar
Sodium salt
Neu5Acα2-3Galβ1-3GalNAcβ1-4Galβ1-4Glc
C37H61N2O29Na
FW 1020.86
HOOC
OH
HO
NHAc
OH
O
HO
AcHN
O
O
O
OH
O
OH
OH
OH
OH
OH
O
O
OH
HO
O
HO
OH
O
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY098
GD1a Ganglioside sugar
Sodium salt
Neu5Acα2-3Galβ1-3GalNAcβ1-4(Neu5Acα2-3)Galβ1-4Glc
HO
C48H77N3O37Na2
FW 1334.09
HOOC
OH
O
HO
AcHN
O
NHAc
OH
OH
O
O O
OH OH
HOOC
O
OH OH
HO
OH
OH
OH
O
O
HO
AcHN
HO
O
O
OH
OH
OH
Functional ligands for myelin stability and the
control of nerve regeneration
Vyas, A et al., 2001. Biochimie. 83(7): 677-82.
GLY099
OH
O
5 mg, 25 mg, 100 mg, 1 g, 5 g
GD1b Ganglioside sugar
Sodium salt
Galβ1-3GalNAcβ1-4(Neu5Acα2-8Neu5Acα2-3)Galβ1-4Glc
C48H77N3O37Na2
FW 1334.09
HO
OH
HO
O
OH
O
NHAc
HOOC
OH
HO
HO
O
HO
AcHN
HO
OH
OH O
HOOC
O
O
OH
O
O
HO
AcHN
O
OH
HO
O
OH
O
OH
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY100
GT1a Ganglioside sugar
Sodium salt
Neu5Acα2-8Neu5Acα2-3Galβ1-3GalNAcβ1-4(Neu5Acα2-3)Galβ1-4Glc
OH
OH
HO
HO
AcHN
HO
HOOC
O
HO HO
O
HOOC
O
HO
AcHN
OH
O
HOOC
O
HO
AcHN
OH
OH
HO
OH
O
AcNH
O
O
OH OH
C59H93N4O45Na3
FW 1647.33
O
OH
O
O
OH
O
HO
OH
O
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
GLY101
GT1c Ganglioside sugar
Sodium salt
C59H93N4O45Na3
FW 1647.33
Galβ1-3GalNAcβ1-4(Neu5Acα2-8Neu5Acα2-8Neu5Acα2-3)Galβ1-4Glc
OH
HO
HOOC
O
HO
AcHN
O
HO HO
HOOC
HO
AcHN
O
HOOC
O
HO HO
O
HO
AcHN
OH
OH
HO
OH
O
O
O
OH OH
GLY102
O
AcNH
O
O
HO
OH OH
OH
OH
OH
O
OH
O
5 mg, 25 mg, 100 mg, 1 g, 5 g
aGM1 (asialo GM1) Ganglioside sugar / GA1
Galβ1-3GalNAcβ1-4Galβ1-4Glc
OH
HO
O
O
OH
OH
OH
[75645-24-8]
OH
O
O
HO
C26H45NO21
FW 707.62
NHAc
OH
O
HO
O
HO
OH
O
OH
GLY103
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Fucosyl GM1 Ganglioside sugar
Sodium salt
Fucα1-2Galβ1-3GalNAcβ1-4(Neu5Acα2-3)Galβ1-4Glc
OH
OH
C43H71N2O33Na
FW 1168.00
HO
O
HO
O
HO
OH
O
O
NHAc
HO
OH O
HOOC
OH
O
OH
HO
O
HO
AcHN
O
O
OH
HO
O
OH
O
OH
OH
OH
Tumor associated carbohydrate antigen expressed
in small cell lung cancer (TACA)
Dickler. MN et al,. Clin Cancer Res. 1999. Oct ; 5(10):
2773-9
GLY104
5 mg, 25 mg, 100 mg, 1 g, 5 g
aGM2 (asialo GM2) Ganglioside sugar / GA2
GalNAcβ1-4Galβ1-4Glc
C20H35NO16
FW 545.48
NHAc
HO
O
O
HO
OH
OH
O
HO
OH
122
OH
OH
HO
O
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
Glycan oligosaccharides
Globo-Series (P antigens)
Production by bacterial fermentation
Product description
Globosides are major components of human erythrocytes and were termed like this since it was
obtained as a globular precipitate. Glycosphingolipids (GLS’s) of the globo-series are membraneassociated antigens possessing as structural feature a Galα1-4Gal (galabiose-like) linkage which is
responsible for their specific roles in recognition and cell differentiation. They are recognized by
proteins of pathogenic E. coli in human epithelial cells of the urinary tract. They are also receptors
for Shiga toxin and verotoxin (Shiga-like toxin) and constitute the basis of the P-blood group
system. Many of them have been described as tumor-associated antigens.
Galα1-4Galβ1-4Glc
The inner carbohydrate core structure of all globo-series GSL
x
The P blood group antigens are expressed on glycolipids of the red cell membrane and in
tissues, including the urothelium.
x
The stage specific embryogenic antigens (also known as SSEA) are highly expressed in
early embryo or embryonal carcinoma of mouse, primates and humans and are assumed to
be important functional molecules involved in defining stage of stem cell development.
x
The Forssman antigens are glycolipids that very closely resembles the Globo H antigen as
they share an identical Gb4 tetrasaccharide core. It is species specific as expressed in some
mammals (e.g., sheep, dogs, horses, etc.) but not in others (rabbits, pigs, humans, etc.).
Interestingly, it is present in several forms of human cancers making it a potential
candidate for cancer therapy.
CFG nomenclature
http://www.functionalglycomics.org/static/consortium/Nomenclature.shtml
Globo-H
SSEA-3b
Fucose
α2
Galactose
N-Acetyl
Galactosamine
α2-3
β3
β3
Glucose
N-Acetyl
Glucosamine
N-Acetyl Neuraminic Acid /
Sialic Acid
α4
β4
β1-Ceramide
Globotriaose Gb3
Pk antigen
Globotetraose Gb4
P antigen
Globopentaose Gb5
SSEA-3a
Sialyl-Globopentaose Gb5
SSEA-4
x
x
Further readings:
A.J. Wright, P.W. Andrews. Stem Cell Research (2009) 3, 3-11.
For more information please refer to our Tumor-associated carbohydrate antigens
(TACA) brochure
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OligoTech®
P Blood group antigens & Analogues
GLY120
Globotriaose (Gb3)
Pk antigen
Galα1-4Galβ1-4Glc
OH
C18H32O16
FW 504.43
OH
[66580-68-5]
O
HO
OH
O
OH
OH
O
OH
HO
O
HO
O
OH
OH
Tumor associated antigen expressed in Burkitt's
lymphoma (TACA)
Wiels J et al., 1984. J Biol Chem. Dec
10;259(23):14783-7
GLY121
5 mg, 25 mg, 100 mg, 1 g, 5 g
Globotetraose (Gb4)
P antigen
GalNAcβ1-3Galα1-4Galβ1-4Glc
OH
OH
OH
C26H45NO21
FW 707.62
OH
O
[75660-79-6]
O
HO
O
NHAc
OH
O
OH
OH
O
OH
O
OH
Receptor of B19 parvovirus
Brown KE et al,. 1993. Science. 262 :114-117.
GLY135
OH
HO
O
HO
5 mg, 25 mg, 100 mg, 1 g, 5 g
Globotriaose analogue type 1
Galα1-4Galβ1-3GlcNAc
OH
C20H35NO16
FW 545.48
OH
O
HO
OH
O
OH
OH
O
O
HO
O
HO
OH
NHAc
OH
GLY136
5 mg, 25 mg, 100 mg, 1 g, 5 g
Globotriaose analogue type 2/ P1 antigen
Galα1-4Galβ1-4GlcNAc
OH
C20H35NO16
FW 545.48
OH
O
HO
OH
O
OH
O
HO
OH
124
NHAc
OH
HO
O
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
GLY171
Sialylated globotriaose/ 3Sialyl-Gb3
Sodium salt
Neu5Acα2-3Galα1-4Galβ1-4Glc
HOOC
OH
HO
OH
OH
O
O
HO
AcHN
C29H48NO24Na
FW 817.67
O
OH
OH
O
OH
OH
O
OH
HO
O
HO
O
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Globo-Series (Core structure type 4)
GLY127
Globo-H tetraose / Blood group H antigen tetraose type 4
Fucα1-2Galβ1-3GalNAcβ1-3Gal
OH
OH
OH
OH
OH
O
C26H45NO20
FW 691.62
OH
O
O
O
HO
OH
O
O
NHAc
OH
O
OH
HO OH
GLY124
5 mg, 25 mg, 100 mg, 1 g, 5 g
Globo-A heptaose
GalNAcα1-3(Fucα1-2)Galβ1-3GalNAcβ1-3Galα1-4Galβ1-4Glc
OH
C46H78N2O35
FW 1219.09
OH
O
OH
OH
OH
OH
OH
O
OH
O
O
O
AcHN
O
O
O
OH
NHAc
O
O
OH
HO
OH
OH
HO
O
HO
O
OH
Tumor associated antigen expressed in human
kidney cancer (TACA)
Breimer, M. and Jovall, P.A. 1985. FEBS Lett. 179,
165-172
GLY125
OH
O
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Globo-B heptaose
Galα1-3(Fucα1-2)Galβ1-3GalNAcβ1-3Galα1-4Galβ1-4Glc
OH
C44H75NO35
FW 1178.04
OH
O
OH
HO
OH
OH
O
OH
OH
O
O
OH
O
O
O
OH
O
NHAc
OH
O
O
HO OH
OH
O
OH
HO
OH
OH
OH
HO
O
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
Stage-specific embryonic antigens (SSEA-3 & 4)
GLY122
Globopentaose (Gb5)
Stage Specific Embryonic Antigen 3a (SSEA-3a)
Galβ1-3GalNAcβ1-3Galα1-4Galβ1-4Glc
OH
OH
OH
OH
OH
O
O
[71937-76-3]
O
O
HO
C32H55NO26
FW 869.76
OH
O
OH
NHAc
OH
O
OH
OH
O
OH
HO
O
HO
O
OH
OH
Tumor associated antigen expressed in testicular
cancer (TACA)
Olie et al,. Br J Cancer. 1996. 74, 133-140
GLY123
5 mg, 25 mg, 100 mg, 1 g, 5 g
Globo-H hexaose
Stage Specific Embryonic Antigen 3b (SSEA-3b)
Fucα1-2Galβ1-3GalNAcβ1-3Galα1-4Galβ1-4Glc
OH
OH
OH
OH
OH
OH
O
O
O
O
O
HO
O
NHAc
OH
O
O
OH
OH
HO
OH
O
OH
HO
O
HO
OH
Tumor associated antigen expressed in various
types of cancer (breast, prostate, ovarian)
Zhang et al., 1998. Clin Cancer Res. Feb; 4(2):295-302
Hakomori. 1990. Hum. Canc Immunol. 10:781-802
GLY130
C38H65NO30
FW 1015.90
O
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
SSEA-4 tetraose
Stage-Specific Embryonic Antigen-4
Sodium salt
Neu5Acα2-3Galβ1-3GalNAcβ1-3Gal
OH
COOH
OH
HO
O
HO
AcHN
OH
OH
OH
OH
OH
O
O
O
O
O
O
OH
C31H51N2O24Na
FW 858.72
OH
OH
NHAc
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY131
SSEA-4 hexaose
Stage-Specific Embryonic Antigen-4
Sodium salt
Neu5Acα2-3Galβ1-3GalNAcβ1-3Galα1-4Galβ1-4Glc
OH
COOH
OH
HO
O
HO
AcHN
OH
OH
OH
OH
OH
O
O
OH
C43H71N2O34Na
FW 1183.00
O
O
O
O
OH
NHAc
OH
O
OH
O
HO
OH
OH
OH
HO
O
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
126
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OligoTech®
Forssman antigens
GLY132
Forssman antigen pentaose
GalNAcα1-3GalNAcβ1-3Galα1-4Galβ1-4Glc
OH
C34H58N2O26
FW 910.82
OH
O
HO
NHAc
OH
OH
OH
OH
O
O
O
O
NHAc
OH
O
OH
O
HO
OH
OH
Tumor associated antigen expressed in gastric
cancer
Hirayama R et al,. 1989. Cancer. Apr 15;63(8):1528-33
GLY133
OH
HO
O
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Forssman antigen triaose
GalNAcα1-3GalNAcβ1-3Gal
OH
C22H38N2O16
FW 586.54
OH
O
OH
HO
NHAc
O
OH
OH
OH
O
O
O
NHAc
OH
OH
Tumor associated antigen expressed in gastric
cancer
Hirayama R et al,. 1989. Cancer. Apr 15;63(8):1528-33
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
Glycan oligosaccharides
Glucuronylated oligosaccharides
Production by bacterial fermentation
GLY180
Glucuronyl-lactose
HNK 1 epitope precursor
Sodium salt
GlcAβ1-3Galβ1-4Glc
C18H29O17Na
FW 540.00
COOH
HO
HO
OH
OH
O
O
O
OH
OH
OH
HO
O
OH
O
OH
precursor of the brain carbohydrate motif
HNK-1, involved in neural cell adhesion
5 mg, 25 mg, 100 mg, 1 g, 5
g
Glycobiology, 18, n°2, pp. 152–157, 2008
GLY181
Glucuronyl-LNT
Glucuronyl-Lacto-N-tetraose
Sodium salt
GlcAβ1-3Galβ1-3GlcNAcβ1-3Galβ1-4Glc
HO
HO
OH
COOH
O
OH
OH
O
O
OH
C32H52NO27 Na
FW 883.75
OH
HO
OH
OH
O
O
O
O
NHAc
OH
OH
OH
HO
O
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
128
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OligoTech®
Glycan oligosaccharides
Miscellaneous
Production by bacterial fermentation
Trehalose-like oligosaccharides
GLY160
Galactosyl-lactose
Galβ1-4Glcβ1-1βGal
OH
C18H32O16
FW 504.43
OH
OH
O
HO
O
HO
HO
O
OH
O
OH
O
OH
OH OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY161
Difucosylpentaose
Fucα1-2Galβ1-4Glcβ1-1βGalα2-1Fuc
C30H52O24
FW 796.71
OH OH
HO
O
OH
OH
O
HO
OH
HO
O
O
O
O
O
OH
O
OH
OH OH
O
OH
HO OH
GLY162
5 mg, 25 mg, 100 mg, 1 g, 5 g
Disialosylpentaose
Sodium salt
Neu5Acα2-3Galβ1-4Glcβ1-1βGalα2-3Neu5Ac
C40H64N2O32Na2
FW 1130.90
OH
AcH
N
OH
OH
HO
O
HOOC
OH
HO
O
HO
AcHN
OH
OH
OH
O
O
OH
OH
HO
O
O
OH
COOH
HO
O
O
O
OH OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
Blood group-related oligosaccharides
GLY163
2'2 DiFucosyllactose
Fucα1-2Galβ1-4(Fucα1-2)Glc
C24H42O19
FW 634.57
OH OH
HO
O
OH
OH
O
HO
O
HO
O
OH
O
O
OH
O
OH
HO
GLY164
5 mg, 25 mg, 100 mg, 1 g, 5 g
OH
Fucosylated A antigen type 5
GalNAcα1-3(Fucα1-2)Galβ1-4(Fucα1-2)Glc
OH
OH
HO
OH
C32H55NO24
FW 837.77
OH
O
O
HO
OH
OH
O
O
AcHN
O
OH
HO
O
O
O
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
HO OH
GLY165
Fucosylated B antigen type 5
Galα1-3(Fucα1-2)Galβ1-4(Fucα1-2)Glc
C30H52O24
FW 796.71
OH OH
OH
HO
OH
O
O
OH
HO
OH
O
OH
O
O
HO
O
OH
O
O
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
HO OH
Globo-Series analogues (Core structure type 1 & 2)
GLY190
Globotetraose analogue / Gb4 analogue
GlcNAcβ1-3Galα1-4Galβ1-4Glc
OH
OH
HO
HO
C26H45NO21
FW 707.62
OH
O
O
O
NHAc
OH
O
OH
O
HO
OH
130
OH
OH
HO
O
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
GLY191-1
Globopentaose analogue type 1
Gb5 analogue type 1
Galβ1-3GlcNAcβ1-3Galα1-4Galβ1-4Glc
OH
OH
OH
OH
O
HO
OH
O
O
HO
O
C32H55NO26
FW 869.76
O
OH
NHAc
OH
O
OH
OH
O
OH
HO
O
HO
O
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY191-2
Globopentaose analogue type 2
Gb5 analogue type 2
Galβ1-4GlcNAcβ1-3Galα1-4Galβ1-4Glc
OH
OH
OH
OH
AcNH
O
HO
O
HO
C32H55NO26
FW 869.76
O
O
O
OH
OH
OH
O
OH
OH
O
OH
HO
O
HO
O
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY192
Globotetraose Lewisa analogue
Gb4-Lewisa analogue
Galβ1-3(Fucα1-4)GlcNAcβ1-3Galα1-4Galβ1-4Glc
OH
HO
OH
O
OH
OH
OH
O
OH
O
O
O
O
HO
C38H65NO30
FW 1015.90
OH
O
OH
NHAc
OH
O
OH
O
HO
OH
OH
HO
O
O
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY193
Globotetraose Lewisx analogue
Gb4-Lewisx analogue
Galβ1-4(Fucα1-3)GlcNAcβ1-3Galα1-4Galβ1-4Glc
OH
HO
OH
OH
O
OH
AcNH
O
O
HO
OH
C38H65NO30
FW 1015.90
OH
O
OH
O
O
O
OH
OH
O
OH
O
HO
OH
OH
OH
HO
O
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
GLY194-1
Globo-H analogue type 1
Fucα1-2Galβ1-3GlcNAcβ1-3Galα1-4Galβ1-4Glc
OH
OH
OH
OH
O
O
O
HO
O
HO
C38H65NO30
FW 1015.90
OH
O
NHAc
O
OH
O
OH
OH
O
O
OH
HO OH
OH
HO
O
HO
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY194-2
Globo-H analogue type 2
Fucα1-2Galβ1-4GlcNAcβ1-3Galα1-4Galβ1-4Glc
OH
OH
OH
O
HO
AcNH
HO
O
O
O
O
O
OH
OH
O
OH
OH
O
O
OH
OH
HO
O
HO
OH
OH
C38H65NO30
FW 1015.90
OH
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY195-1
SSEA-4 hexaose analogue type 1
Sodium salt
NeuAcα2-3Galβ1-3GlcNAcβ1-3Galα1-4Galβ1-4Glc
HOOC
OH
HO
O
HO
AcHN
OH
O
O
OH
OH
OH
OH
HO
O
O
O
O
NHAc
OH
C43H71N2O34Na
FW 1183.00
OH
OH
O
OH
OH
O
OH
HO
O
HO
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY195-2
SSEA-4 hexaose analogue type 2
Sodium salt
NeuAcα2-3Galβ1-4GlcNAcβ1-3Galα1-4Galβ1-4Glc
OH
HOOC
OH
OH
HO
O
HO
AcHN
OH
OH
O
O
OH
AcNH
HO
O
C43H71N2O34Na
FW 1183.00
OH
O
O
O
OH
O
OH
OH
O
HO
OH
OH
OH
HO
O
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
132
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OligoTech®
GLY196-1
Sialylated-SSEA-4 hexaose analogue type 1
Sodium salt
C54H87N3O42Na2
FW 1496.23
NeuAcα2-8NeuAcα2-3Galβ1-3GlcNAcβ1-3Galα1-4Galβ1-4Glc
HOOC
OH
HO
O
HO
AcHN
OH HO
HOOC
O
OH
O
O
HO
AcHN
OH
O
HO
O
O
OH
OH
OH
OH
O
O
NHAc
OH
OH
O
OH
OH
O
OH
HO
O
HO
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY196-2
Sialylated-SSEA-4 hexaose analogue type 2
Sodium salt
C54H87N3O42Na2
FW 1496.23
NeuAcα2-8NeuAcα2-3Galβ1-4GlcNAcβ1-3Galα1-4Galβ1-4Glc
HOOC
OH
HO
O
HO
AcHN
OH
O
OH
HOOC
OH
OH
HO
O
O
HO
AcHN
O
OH
OH
AcNH
HO
O
O
O
O
OH
OH
O
OH
OH
O
HO
OH
OH
HO
O
O
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Isoglobo-Series analogues (Core structure type 1 & 2)
GLY197
Isoglobotetraose analogue / iGb4 analogue
GlcNAcβ1-3Galα1-3Galβ1-4Glc
OH
OH
OH
O
HO
HO
C26H45NO21
FW 707.62
O
OH
O
NHAc
OH
OH
OH
O
OH
HO
O
O
O
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY198-1
Isoglobopentaose analogue type 1/ iGb5 analogue type 1
Galβ1-3GlcNAcβ1-3Galα1-3Galβ1-4Glc
OH
OH
OH
OH
O
HO
OH
HO
O
O
C32H55NO26
FW 869.76
OH
O
OH
O
NHAc
OH
OH
O
O
OH
OH
OH
HO
O
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
GLY198-2
Isoglobopentaose analogue type 2 / iGb5 analogue type 2
Galβ1-4GlcNAcβ1-3Galα1-3Galβ1-4Glc
OH
OH
OH
OH
NHAc
O
HO
O
HO
C32H55NO26
FW 869.76
O
OH
O
O
OH
OH
OH
OH
OH
O
OH
HO
O
O
O
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY199
Isoglobotetraose Lewisa analogue
iGb4-Lewisa analogue
Galβ1-3(Fucα1-4)GlcNAcβ1-3Galα1-3Galβ1-4Glc
OH
HO
OH
O
OH
OH
OH
O
HO
C38H65NO30
FW 1015.90
OH
O
O
OH
O
O
OH
O
NHAc
OH
OH
OH
OH
O
OH
HO
O
O
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY200
Isoglobotetraose Lewisx analogue type 2
iGb4-Lewisx analogue type 2
Galβ1-4(Fucα1-3)GlcNAcβ1-3Galα1-3Galβ1-4Glc
OH
HO
OH
O
OH
OH
O
HO
OH
NHAc
O
OH
C38H65NO30
FW 1015.90
OH
O
O
OH
O
O
OH
OH
OH
O
O
OH
OH
HO
O
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY201-1
Isoglobo-H analogue type 1
Fucα1-2Galβ1-3GlcNAcβ1-3Galα1-3Galβ1-4Glc
OH
OH
HO
O
O
OH
HO OH
134
OH
OH
O
HO
O
OH
O
OH
O
O
NHAc
C38H65NO30
FW 1015.90
OH
OH
O
O
OH
OH
OH
HO
O
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
GLY201-2
Isoglobo-H analogue type 2
Fucα1-2Galβ1-4GlcNAcβ1-3Galα1-3Galβ1-4Glc
OH
OH
OH
O
HO
HO
O
O
OH
O
O
O
C38H65NO30
FW 1015.90
OH
AcNH
OH
OH
OH
O
OH
O
O
OH
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
HO OH
GLY202-1
OH
HO
O
O
Sialylated isoglobopentaose analogue type 1
Sialylated iGb5 analogue type 1
Sodium salt
NeuAcα2-3Galβ1-3GlcNAcβ1-3Galα1-3Galβ1-4Glc
C43H71N2O34Na
FW 1183.00
HOOC
OH
HO
OH
OH
O
HO
O
O
OH
OH
OH
O
O
HO
AcHN
OH
O
OH
O
NHAc
OH
OH
OH
O
OH
OH
HO
O
O
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY202-2
Sialylated isoglobopentaose analogue type 2
Sialylated iGb5 analogue type 2
Sodium salt
NeuAcα2-3Galβ1-4GlcNAcβ1-3Galα1-3Galβ1-4Glc
C43H71N2O34Na
FW 1183.00
HOOC
OH
HO
O
HO
AcHN
OH
OH
OH
NHAc
O
HO
O
O
O
OH
O
O
OH
OH
OH
OH
OH
OH
OH
O
OH
HO
O
O
O
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY203-1
Disialylated isoglobopentaose analogue type 1
Disialylated iGb5 analogue type 1
Sodium salt
C54H87N3O42Na2
FW 1496.23
NeuAcα2-8NeuAcα2-3Galβ1-3GlcNAcβ1-3Galα1-3Galβ1-4Glc
HOOC
OH
HO
O
HO
AcHN
OH HO
HOOC
O
OH
OH
OH
O
HO
O
O
OH
OH
OH
O
O
HO
AcHN
O
OH
O
NHAc
OH
OH
OH
OH
O
OH
HO
O
O
O
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY203-2
Disialylated isoglobopentaose analogue type 2
Disialylated iGb5 analogue type 2
Sodium salt
C54H87N3O42Na2
FW 1496.23
NeuAcα2-8NeuAcα2-3Galβ1-4GlcNAcβ1-3Galα1-3Galβ1-4Glc
HOOC
OH
HO
O
HO
AcHN
OH
HOOC
O
HO
O
HO
AcHN
OH
OH
OH
OH
NHAc
O
O
OH
HO
O
OH
O
OH
O
O
OH
OH
OH
O
O
OH
OH
HO
O
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
Ganglio-Series analogues
GLY111
GM2 Ganglioside sugar analogue
Sodium salt
Galβ1-4(Neu5Acα2-3)Galβ1-4Glc
C29H48NO24Na
FW 817.67
HOOC
OH
HO
O
HO
AcHN
OH
OH
O
OH
OH
O
HO
O
O
O
O
HO
OH
OH
OH
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY173
GalNAc-aGM1 (GalNAc-asialo GM1) Ganglioside sugar
GalNAcβ1-4Galβ1-3GalNAcβ1-4Galβ1-4Glc
NHAc
OH
OH
HO
OH
OH
OH
OH
O
O
O
HO
O
O
O
C34H58N2O26
FW 910.82
O
OH
HO
NHAc
OH
HO
O
OH
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY174
GalGalNac-aGM1 (GalGalNAc asialo GM1) Ganglioside sugar
Galβ1-3GalNAcβ1-4Galβ1-3GalNAcβ1-4Galβ1-4Glc
OH
OH
OH
O
HO
OH
O
HO
OH
O
O
NHAc
O
O
O
O
OH
C40H68N2O31
FW 1072.95
NHAc
OH
OH
OH
O
OH
HO
OH
OH
HO
O
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
136
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OligoTech®
Monosaccharides,
Di-, Tri-, Tetrasaccharides
Production by bacterial fermentation
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OligoTech®
Glycan oligosaccharides
Monosaccharides
Production by bacterial fermentation
GLY140
Sialic acid (N-acetylneuraminic acid)
NeuAc
HOOC
OH
HO
[131-48-6]
O
HO
AcHN
Sodium salt
C11H18NO9Na
FW 331.26
OH
OH
1 g, 5 g
GLY141
N-acetylgalactosamine
GalNAc
OH
C8H15NO6
FW 221.21
OH
[1811-31-0]
O
HO
OH
NHAc
1 g, 5 g
GLY142
N-acetylmannosamine
ManNAc
HO
HO
HO
C8H15NO6
FW 221.21
NHAc
O
[3615-17-6]
OH
1 g, 5 g
GLY143
L-fucose
Fuc
OH
C6H12O5
FW 164.15
[2438-80-4]
O
OH
HO OH
138
1 g, 5 g
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OligoTech®
Glycan oligosaccharides
Di-Tri-Tetrasaccharides
Production by bacterial fermentation
Disaccharides
GLY151
GalNAcβ1-3Gal / Gb4 Globoside terminal
OH
OH
OH
C14H25NO11
FW 383.35
OH
O
O
HO
OH
O
NHAc
OH
“Common oligosaccharide moieties inhibit the adherence of typical and
atypical respiratory pathogens”
R. Thomas and T. Brooks, Journal of Medical Microbiology (2004), 53, 833–
840
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY153
α1-3 galactobiose
Galα1-3Gal
OH
C12H22O11
FW 342.29
OH
[13168-24-6]
O
OH
HO
OH
O
OH
OH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY154
α1-4 galactobiose
Galα1-4Gal/ Galabiose
OH
C12H22O11
FW 342.29
OH
O
[80446-85-1]
HO
OH
O
OH
O
HO
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
OH
GLY155
GlcNAcβ1-3Gal
OH
OH
HO
HO
O
O
OH
O
NHAc
C14H25NO11
FW 383.35
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
GLY156
N,N’-diacetylchitobiose
Chitinbiose)
GlcNAcβ1-4GlcNAc
C16H28N2O11
FW 424.40
OH
HO
HO
HO
O
OH
O
AcNH
GLY157
[35061-50-8]
AcNH
O
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
3 Sialylgalactose
Sodium salt
Neu5Acα2-3Gal
C17H28NO14Na
FW 493.40
HOOC
OH
HO
HO
AcHN
OH
OH
O
O
O
OH
OH
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
Trisaccharides
GLY158
Galα1-4Galα1-4Gal
Galα1-4Galα1-4Gal
OH
C18H32O16
FW 504.43
OH
O
HO
OH
O
OH
O
HO
OH
O
OH
O
HO
OH
5 mg, 25 mg, 100 mg, 1 g, 5 g
OH
Tetrasaccharides
GLY159
Galα1-4Galα1-4Galα1-4Gal
Galα1-4Galα1-4Galα1-4Gal
OH
C24H42O21
FW 666.57
OH
O
HO
OH
O
OH
O
HO
OH
O
OH
O
HO
OH
O
OH
O
HO
OH
OH
140
5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
GlycoBricks®
Functionalized Glycans
Production by bacterial fermentation
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OligoTech®
GlycoBBricks®
Functionalized Glycans
About GlycoBricks®
x
GlycoBricks® are functionalized oligosaccharides derived from bioactive oligosaccharides
x
A choice of different types of activated groups is proposed at the reducing end of the
Glycobricks®:
Spacer+Propargyl
AminoPropyl
Spacer is to be defined following the request and can be an O, an N-Acetyl, or an aliphatic group
x
Any customized Glycobricks® request is evaluated covering all oligosaccharides disclosed in
this catalogue and beyond on demand.
x
The products are available from the mg to the multi-gram scale.
x
They are produced through manufacturable process to anticipate potential industrial
application
GlycoBricks® Applications
Affinity
adsorbents
GlycoBrick
142
®
• Beads / Resins
• Purification / removal of antibodies,
viruses, toxins, lectins
• Immunology studies
Click chemistry
• Building of macromolecular architectures
(glycoclusters, dendrimers...)
• Ready for glycan array immobilization
Labeled
oligosaccharides
• Fluorescent probes or biotin
• Imaging, analysis of interactions,
analysis by HPLC, targeting
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OligoTech®
GlycoBBricks®
Functionalized Glycans
Each glycan or natural oligosaccharide structures proposed in this catalogue can be potentially
functionalized by Aminopropyl and / or Propargyl reactive groups.
The following items are examples of glycobricks already made and available on the shelf.
GLY034AP
Blood group A antigen triaose-β-Aminopropyl
GalNAcα1-3(Fucα1-2)Galβ-O-(CH2)3-NH2
OH
C23H42N2O15
FW 586.58
OH
O
HO
OH
OH
O
AcHN
O
O
NH2
O
O
OH
HO OH
NEW
1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY036-1PR
Blood group A antigen pentaose type 1-β-Propargyl
GalNAcα1-3(Fucα1-2)Galβ1-3GlcNAcβ1-3Galβ-O-CH2-C{CH
OH
C37H60N2O25
FW 932.86
OH
O
HO
OH
OH
OH
O
AcHN
O
HO
OH
OH
O
O
O
O
O
NHAc
O
OH
O
OH
HO OH
NEW
1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY037-1NPR
OH
Blood group A antigen hexaose type 1-β-N-Acetyl Propargyl
GalNAcα1-3(Fucα1-2)Galβ1-3GlcNAcβ1-3Galβ1-4Glcβ-NAc-CH2-C{CH
OH
O
HO
OH
OH
OH
O
AcHN
O
HO
O
OH
OH
OH
O
O
NHAc
N
HO
O
O
O
C45H73N3O30
FW 1136.06
OH
O
Ac
OH
O
OH
HO
NEW
OH
1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
GLY058-AP
Blood group B antigen triaose-β-Aminopropyl
Galα1-3(Fucα1-2)Galβ-O-(CH2)3-NH2
OH
C21H39NO15
FW 545.53
OH
O
HO
OH
OH
O
OH
O
NH2
O
O
O
OH
HO OH
NEW
1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY040-1NPR
Blood group B antigen hexaose type 1-β-N-Acetyl
Propargyl
Galα1-3(Fucα1-2)Galβ1-3GlcNAcβ1-3Galβ1-4Glcβ-NAc-CH2-C{CH
OH
OH
C43H70N2O30
FW 1095.00
O
HO
OH
OH
OH
O
OH
O
HO
OH
OH
OH
O
O
O
NHAc
O
N
HO
O
O
O
OH
Ac
OH
O
OH
HO
OH
NEW
1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY050-PR
LewisX tetraose-β-Propargyl
Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ-O-CH2-C{CH
C29H47NO20
FW 729.67
OH
OH
HO
O
OH
OH
AcNH
O
HO
OH
O
O
O
O
O
O
OH
OH
OH
OH
NEW
1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g
GLY053-PR
Sialyl LewisX pentaose-β-Propargyl
Sodium salt
Neu5Acα2-3Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ-O-CH2-C{CH
OH
C40H63N2O28Na
FW 1042.91
OH
HO
O
HOOC
OH
HO
O
HO
AcHN
OH
NEW
144
OH
OH
AcNH
O
O
OH
OH
O
O
O
O
O
O
OH
OH
OH
1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
Lewisb pentaose-β-N-Acetyl Propargyl
GLY056NPR
Fucα1-2Galβ1-3(Fucα1-4)GlcNAcβ1-3Galβ-NAc-CH2-C{CH
OH
HO
OH
O
OH
OH
O
HO
C37H60N2O24
FW 913.87
OH
O
OH
OH
O
O
O
O
N
NHAc
O
Ac
OH
O
OH
NEW
HO
GLY090-AP
OH
1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g
3'Sialyllactose-β-Aminopropyl
GM3 Ganglioside sugar-β-Aminopropyl
Sodium salt
Neu5Acα2-3Galβ1-4Glcβ-O-(CH2)3-NH2
OH
HOOC
HO
HO
AcHN
OH
OH
O
O
C26H45N2O19Na
FW 712.62
O
OH
HO
O
OH
OH
NH2
O
O
OH
1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g
NEW
GLY090NPR
3'Sialyllactose-β-N-Acetyl Propargyl
GM3 Ganglioside sugar-β-N-Acetyl Propargyl
Sodium salt
Neu5Acα2-3Galβ1-4Glcβ-NAc-CH2-C{CH
OH
HOOC
HO
OH
O
O
HO
AcHN
C28H43N2O19Na
FW 734.63
OH
O
OH
HO
O
N
O
OH
OH
Ac
OH
1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g
NEW
GLY094NPR
GD2 Ganglioside sugar-β-N-Acetyl Propargyl
Sodium salt
GalNAcβ1-4(Neu5Acα2-8Neu5Acα2-3)Galβ1-4Glcβ-NAc-CH2-C{CH
C47H72N4O32Na2
FW 1251.05
HO
OH
HO
HO
AcHN
NHAc
HOOC
O
HO
OH
HO
O
OH O
HOOC
O
HO
AcHN
OH
O
OH
O
O
OH
OH
HO
O
N
O
OH
Ac
1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g
NEW
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OligoTech®
GLY096-AP
GM1a Ganglioside sugar-β-Aminopropyl
Sodium salt
Galβ1-3GalNAcβ1-4(Neu5Acα2-3)Galβ1-4Glcβ-O-(CH2)3-NH2
C40H68N3O29 Na
FW 1077.95
HO
OH
HO
O
OH
O
NHAc
HO
OH O
HOOC
OH
O
OH
HO
OH
O
O
HO
AcHN
HO
O
O
OH
OH
NH2
O
O
OH
1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g
NEW
GLY096NPR
GM1a Ganglioside sugar-β-N-Acetyl Propargyl
Sodium salt
Galβ1-3GalNAcβ1-4(Neu5Acα2-3)Galβ1-4Glcβ-NAc-CH2-C{CH
C42H66N3O29Na
FW 1099.96
HO
OH
HO
OH
O
O
NHAc
HO
OH
OH O
HOOC
O
OH
HO
OH
O
O
HO
AcHN
HO
O
O
OH
OH
Ac
OH
1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g
NEW
GLY098NPR
N
O
GD1a Ganglioside sugar-β-N-Acetyl Propargyl
Sodium salt
Neu5Acα2-3Galβ1-3GalNAcβ1-4(Neu5Acα2-3)Galβ1-4Glcβ-NAc-CH2-C{CH
HO
C53H82N4O37Na2
FW 1413.19
HOOC
OH
O
HO
AcHN
O
NHAc
OH
OH
O
O
OH OH
HO
OH
O O
OH OH
HOOC
O
HO
AcHN
OH
O
O
OH
OH
N
HO
O
O
Ac
OH
1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g
NEW
146
OH
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OligoTech®
GLY120NPR
Globotriaose /Gb3-β-N-Acetyl Propargyl
Pk antigen-β-N-Acetyl Propargyl
Galα1-4Galβ1-4Glcβ-NAc-CH2-C{CH
OH
C23H37NO16
FW 588.53
OH
O
HO
OH
O
OH
OH
O
N
HO
O
HO
O
OH
Ac
OH
1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g
NEW
GLY123NPR
Globo-H-β-N-Acetyl Propargyl
SSEA-3b-β-N-Acetyl Propargyl
Fucα1-2Galβ1-3GalNAcβ1-3Galα1-4Galβ1-4Glcβ-NAc-CH2-C{CH
OH
OH
OH
OH
OH
OH
O
O
O
O
O
HO
C43H70N2O30
FW 1095.00
O
NHAc
OH
O
O
OH
O
OH
HO
HO OH
OH
OH
N
HO
O
O
Ac
OH
1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g
NEW
GLY220-NPR
Lactose-β-N-Acetyl Propargyl
Galβ1-4Glcβ-NAc-CH2-C{CH
OH
OH
OH
O
OH
GLY221-AP
N
HO
O
HO
NEW
C17H27NO11
FW 421.39
O
Ac
OH
1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g
Galactose-β-Aminopropyl
Galβ-O-(CH2)3-NH2
OH
C9H19N1O6
FW 237.25
OH
O
O
HO
OH
NEW
GLY221-PR
NH2
1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g
Galactose-β-Propargyl
Galβ-O-CH2-C{CH
OH
C9H14O6
FW 218.20
OH
O
O
HO
NEW
OH
1 mg, 5 mg, 25 mg, 100 mg, 1 g, 5 g
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OligoTech®
Other functionalized Mono-Disaccharides available upon request
Available prepacks on request
Product
code
Product name
GLY141-PR
N-acetylgalactosamineα-propargyl
Structure
Text formula
GalNAc-α-O-CH{CH
(Tn antigen analogue-αpropargyl)
GLY141-Ab
N-acetylgalactosamineβ-aminooxy
N-GlcNAc-β-O-NH2
(Tn antigen analogue-βaminooxy)
GLY141-Aa
N-acetylgalactosamineα-aminooxy
N-GlcNAc-α-O-NH2
GLY143-Ab
L-Fucose-β-aminooxy
Fuc-β-O-NH2
GLY143-Aa
L-Fucose-α-aminooxy
Fuc-α-O-NH2
GLY143-PR
L-Fucose-α-propargyl
L-Fuc-α-O-CH{CH
GLY220-PR
Lactose-β-propargyl
Galβ1-4Glc-β-OCH{CH
GLY220-Aa
Lactose-β-aminooxy
Galβ1-4Glc-β-O-NH2
GLY221-Ab
Galactose-β-aminooxy
Gal-β-O-NH2
GLY222-Ab
Glucose-β-aminooxy
Glc-β-O-NH2
GLY222-PR
Glucose-β-propargyl
Glc-β-O-CH{CH
148
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OligoTech®
Other functionalized Mono-Disaccharides available upon request
Available prepacks on request
Product
code
Product name
GLY223-AM
Mannose-α-aminooxy
Man-α-O-NH2
GLY223-PR
Mannose-α-propargyl
Man-α-O-CH{CH
GLY224-PR
N-acetylglucosamine-βpropargyl
GlcNAc-β-O-CH{CH
GLY224-Ab
N-acetylglucosamine-βaminooxy
GlcNAc-β-O-NH2
GLY224-Aa
N-acetylglucosamine-αaminooxy
GlcNAc-α-O-NH2
GLY225-PR
Galβ1-3Gal-α-propargyl
Galβ1-3Gal-α-OCH{CH
(TF antigen analogue-αpropargyl)
GLY225-Aa
Galβ1-3Gal-α-aminooxy
Structure
Text formula
Galβ1-3Gal-α-O-NH2
(TF antigen analogue-αaminooxy)
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OligoTech®
Glycosaminoglycans
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OligoTech®
Glycosaminoglycans
Heparosan & derived oligosaccharides
Production by bacterial fermentation
x
Heparosan from E. coli K12 Strain
STRUCTURAL DESCRIPTION
Heparosan is a bacterial glycosaminoglycan composed of regular repeats of 4-β-glucuronyl(1o4)-α-N-acetylglucosaminyl-1 produced and found in the capsule of some pathogenic
bacteria such as Escherichia coli K5 and Pasteurella multocida.
The heparosan skeleton is a precursor of heparin synthesis, and bacterial heparosan itself can
serve as a precursor for the synthesis of non-animal sourced heparin-like products.
GAG070
Heparosan K5 polysaccharide
Sodium salt
Polysaccharide produced by fermentation in engineered E coli K-12 Strain
Average MW: 105 kDa (~DP500)
Osamine/ uronic acids ratio: ~ 1
-
OH
OOC
O
HO
O
O HO
HO
OH
-
NHAc
OH
OOC
O
O
O
O HO
HO
OH
n
NEW
x
NHAc
OH
100 mg, 1 g, 10 g
Heparosan-derived oligosaccharides
STRUCTURAL DESCRIPTION
Heparosan-derived oligosaccharides are produced by bacterial fermentation in engineered
bacteria by Lyase degrading enzyme expression.
We offer a range of oligosaccharides from Dp 2 to Dp 10 (degree of polymerization).
General Formula : ΔGlcAβ(1-4)[GlcNAcα(1-4)GlcAβ(1-4)]nGlcNAc
Glucuronic acid GlcA is unsaturated at the non-reducing end of the oligosaccharides due to
Lyase activity. The C4-C5 double bond absorbs strongly at 232 nm and can be used for
monitoring the oligosaccharides in various separation system.
GAG071
Heparosan-derived oligosaccharide DP2
Sodium salt
ΔGlcAβ(1-4)GlcNAc
-
O
OH
152
O
O HO
HO
NEW
C14H20NO11
FW 401.30
OH
OOC
OH
NHAc
5 mg, 25 mg
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OligoTech®
GAG072
Heparosan-derived oligosaccharide DP4
Sodium salt
ΔGlcAβ(1-4)GlcNAcα(1-4)GlcAβ(1-4)GlcNAc
-
C28H40N2O22Na2
FW 802.59
OH
OOC
O
O
O HO
HO
OH
-
NHAc
OH
OOC
O
O
O
O HO
HO
OH
OH
NHAc
NEW
GAG073
5 mg, 25 mg
Heparosan-derived oligosaccharide DP6
Sodium salt
ΔGlcAβ(1-4)[GlcNAcα(1-4)GlcAβ(1-4)]2GlcNAc
-
C42H60N3O33Na3
FW 1203.89
OH
OOC
O
O
O HO
HO
OH
-
NHAc
OH
OOC
O
O
O
O HO
HO
OH
OH
NHAc
2
NEW
GAG074
5 mg, 25 mg
Heparosan-derived oligosaccharide DP8
Sodium salt
ΔGlcAβ(1-4)[GlcNAcα(1-4)GlcAβ(1-4)]3GlcNAc
-
C56H80N4O44Na4
FW 1605.18
OH
OOC
O
O
O HO
HO
OH
-
NHAc
OH
OOC
O
O
O
O HO
HO
OH
OH
NHAc
3
NEW
GAG075
5 mg, 25 mg
Heparosan-derived oligosaccharide DP10
Sodium salt
ΔGlcAβ(1-4)[GlcNAcα(1-4)GlcAβ(1-4)]4GlcNAc
C70H100N5O55Na5
FW 2006.48
-
OH
OOC
O
O
O HO
HO
OH
-
NHAc
OH
OOC
O
O
O
O HO
HO
OH
NEW
4
OH
NHAc
5 mg, 25 mg
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OligoTech®
Aminoglycoside derivatives
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OligoTech®
Aminoglycoside derivatives
Beyond antibacterial applications, aminoglycoside derivatives are of large interest as a source
of new molecules for the research community for example for dynamic combinatorial
chemistry. Indeed, these compounds can receive many applications (such as potential antiviral
agents, transfection agents or agents useful in chiral -exchange chromatography).
AMG001
Aminoglycoside platform 1
R1=H
R2=H
NHTr
O
R1O
R1O
TrHN
TrHN
O
*
AMG002
NHTr
O
R2
OR1
5
R1=PMB* with:
R2=(CH2)6Br or
(CH2)6N3 or
(CH2)6NH2 or
(CH2)6NHC(O)(CH2)2COOH
5 mg, 25 mg, 100 mg, 1 g, 5 g
PMB=para-methoxybenzyl, Tr=Trityl
Aminoglycoside platform 2
R2=H: neamine
NH2
O
HO
HO
H2N
H2N
O
R2
NH2
O
5
OH
R2=(CH2)nBr or
(CH2)nN3 or
(CH2)nNH2 or
(CH2)6NHC(O)(CH2)2COOH or
(CH2)n-CH3
(n≥ 6)
5 mg, 25 mg, 100 mg, 1 g, 5 g
AMG003
Aminoglycoside platform 3
R2
NHTr
4'
O
O
R1O
TrHN
TrHN
O
HO
NHTr
OR1
*
AMG004
PMB=para-methoxybenzyl, Tr=Trityl
R1=PMB with:
R2=H or
(CH2)nBr or
(CH2)nN3 or
(CH2)nNH2 or
(CH2)nNHC(O)(CH2)2COOH
(n≥ 6)
5 mg, 25 mg, 100 mg, 1 g, 5 g
Aminoglycoside platform 4
NH2
4'
R2
O
O
HO
H2N
H2N
O
HO
NH2
OH
R2=(CH2)nBr or
(CH2)nN3 or
(CH2)nNH2 or
(CH2)nNHC(O)(CH2)2COOH or
(CH2)n-CH3
(n≥ 4)
5 mg, 25 mg, 100 mg, 1 g, 5 g
156
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OligoTech®
Human & Bacterial Lectins
Production by bacterial fermentation
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OligoTech®
Human & Bacterial Lectins
Production by bacterial fermentation
Our Lectin offer
Produced by bacterial fermentation
Ensuring repeatability and reliability of production and structure. heavy metals free, no
glycosylated lectins.
This process allows any scale-up demand fitting your need.
High affinity for ligands
Very low Kd from micromolar range giving a better sensitivity to the ligand.
Fully Characterized, QA/QC policies
Monitoring by ITC (isothermal titration calorimetry) ensuring reliability of calculated Kd for a
given lectin, affinity checking.
Tested on microarray developped by CFG (Consortium for Functional Glycomics). Product
information is also available from CFG web Site.
http://www.functionalglycomics.org/static/consortium/resources.shtml
Crystal structure is available for each lectin.
Calcium dependent (from 5 out of 6 proposed lectins)
Calcium is required for the carbohydrate attachment which is an Asset for using these items
as biotechnology tools for affinity chromatography.
Available with biotine or fluorophore labels on demand (FITC, Cy…)
No alterations of binding properties despite presence of labeling.
Lectin Uses and Applications
158
x
Biomedical research
x
Carbohydrate recognition studies
x
Biochemical tools (glycoproteins purification, …)
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OligoTech®
LEC101
LecB (PA-IIL) from Pseudomonas aeruginosa
Molecular weight
12.75 kDa (monomer)
Oligomerization
Tetramer
Appearance
Lyophilized
Sugar specificity
Fucose
Sugar affinity
Kd for αMeFuc : 0.41 μM
Other known specificity
Lewisa > αMeFuc > Fuc> Man
Properties
Calcium dependent
Caution
Standard conditions of use
LEC102
LecA (PA-IL) from Pseudomonas aeruginosa
Molecular weight
11.73 kDa (monomer)
Oligomerization
Tetramer
Appearance
Lyophilized
Sugar specificity
αGalactose
Sugar affinity
Kd for αMeGal: 50 μM
Other known specificity
αGal disaccharides > αMeGal > βMelGal
Properties
Calcium dependent
Caution
Cytotoxic/requires trained and qualified personnel
LEC202
RSL from Ralstonia solanacearum
Molecular weight
Oligomerization
9.9 kDa (monomer)
Trimer (with 6 fucose binding sites)
Appearance
Lyophilized
Sugar specificity
Fucose
Sugar affinity
Kd for aMeFuc: 0.74 μM
Other known specificity
αFuc1-2Gal > αFuc1-6GlcNAC > αFuc1-4GlcNAC…
Properties
Caution
Pack size
1, 5, 10 mg
Pack size
1, 5, 10 mg
Pack size
Standard conditions of use
1, 5, 10 mg
LEC301
BC2LA from Burkholderia cenocepacia
Molecular weight
13.76 kDa (monomer)
Oligomerization
Dimer
Appearance
Lyophilized
Sugar specificity
Mannose
Sugar affinity
Other known specificity
Kd for aMeMan: 2.75 μM
All αMan- terminating oligosaccharides
Properties
Calcium dependent
Caution
Standard conditions of use
Pack size
1, 5, 10 mg
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OligoTech®
LEC302
BC2LC-Nt from Burkholderia cenocepacia
Molecular weight
19.26 kDa (monomer)
Oligomerization
Trimer
Appearance
Solution in Tris buffer
Sugar specificity
Sugar affinity
Fucose
Kd for Lewisy: 2.4 μM
Other known specificity
Properties
Pack size
Kd for Fuc: 2.7 mM
y
Lewis > H type 1 > Lewisa > ...> Fuc
-
Caution
Standard conditions of use
1 mg/mL
DC-SIGN ECD (extra-cellular domain)
LEC401
Pack size
Human protein produced in E.coli
Molecular weight
38.8 kDa (monomer)
Oligomerization
Tetramer
Solution in 150 mM NaCl, 25 mM
M Tri
Tris
s pH 8,4 mM
CaCl2 buffer
Appearance
Sugar specificity
High Mannose
Other known specificity
Various pathogen surface glycoconjugates
conjugates
(HIV, HCV, CMV, Ebola, Dengue,,
M. tuberculosis...)
Fucose, Lewisx , Lewisy
Properties
Calcium dependent
Caution
Standard conditions of use
Known interaction
0.2 mg, 1 mg
Langerin ECD (extra-cellular domain)
LEC402
Pack size
Human protein produced in E.coli
Molecular weight
Oligomerization
Appearance
Sugar specificity
29.4 kDa (monomer)
Trimer
Solution in 150 mM NaCl, 25 mM Tris pH
H 8,4 mM
CaCl2 buffer
High Mannose
Known interaction
Other known
specificity
Properties
gp120 (HIV), Keratan sulfate
Caution
Standard conditions of use
Sulfated sugars (Sulfated Lewisx , sulfated galactose )
Calcium dependent
0.2 mg, 1 mg
160
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OligoTech®
Index Product code & Product name
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OligoTech®
Product code index
A
ALG100 · 71
ALG101 · 71
ALG102 · 71
ALG103 · 71
ALG104 · 71
ALG105 · 71
ALG300 · 72
ALG310 · 72
ALG320 · 72
ALG330 · 72
ALG500 · 73
ALG510 · 73
ALG520 · 73
ALG530 · 73
AMG001 · 156
AMG002 · 156
AMG003 · 156
AMG004 · 156
ARB105 · 80
F
FRU100 · 83
FRU101 · 83
FRU102 · 83
FRU110 · 83
FRU111 · 83
FRU112 · 84
FRU113 · 84
FRU114 · 84
FRU115 · 84
FRU116 · 84
FRU117 · 84
FRU118 · 84
FRU130 · 84
FUC100 · 47
FUC110 · 48
FUC200 · 47
FUC210 · 48
FUC300 · 47
FUC310 · 48
FUC400 · 47
FUC410 · 48
FUC500 · 47
FUC510 · 48
FUC600 · 47
G
GAG070 · 152
GAG071 · 152
162
GAG072 · 153
GAG073 · 153
GAG074 · 153
GAL100 · 55
GAL101 · 55
GAL110 · 55
GAL111 · 55
GAL112 · 55
GAL200 · 57
GAL300 · 57
GAL400 · 57
GAL500 · 58
GAT100 · 77
GAT101 · 77
GAT102 · 77
GAT103 · 77
GAT110 · 78
GAT111 · 78
GAT112 · 78
GAT200 · 78
GAT300 · 78
GLU1000 · 15
GLU1100 · 18
GLU1101 · 18
GLU1110 · 15
GLU1111 · 15
GLU1112 · 16
GLU1120 · 18
GLU1121 · 18
GLU1122 · 18
GLU1131 · 19
GLU1140 · 19
GLU1141 · 19
GLU1142 · 19
GLU1150 · 19
GLU1151 · 19
GLU1152 · 19
GLU1160 · 16
GLU1161 · 16
GLU1162 · 17
GLU1170 · 19
GLU1171 · 19
GLU1180 · 17
GLU1181 · 17
GLU1182 · 18
GLU200 · 34
GLU300 · 21
GLU301 · 21
GLU302 · 21
GLU303 · 21
GLU304 · 22
GLU305 · 22
GLU306 · 22
GLU308 · 22
GLU309 · 22
GLU311 · 23
GLU312 · 23
GLU313 · 23
GLU314 · 23
GLU315 · 24
GLU316 · 24
GLU317 · 24
GLU318 · 24
GLU319 · 25
GLU320 · 25
GLU322 · 25
GLU330 · 25
GLU340 · 38
GLU410 · 37
GLU411 · 37
GLU420 · 39
GLU421 · 39
GLU422 · 39
GLU423 · 39
GLU424 · 39
GLU425 · 39
GLU426 · 39
GLU432 · 37
GLU433 · 37
GLU434 · 37
GLU435 · 38
GLU436 · 38
GLU437 · 38
GLU500 · 27
GLU501 · 27
GLU510 · 27
GLU600 · 29
GLU601 · 29
GLU602 · 29
GLU610 · 29
GLU611 · 29
GLU700 · 30
GLU800 · 31
GLU900 · 32
GLU910 · 32
GLY005 · 93
GLY006 · 94
GLY008 · 94
GLY009 · 93
GLY010 · 93
GLY011 · 94
GLY021 · 95
GLY022 · 95
GLY023 · 95
GLY030 · 97
GLY031-1 · 97
GLY031-2 · 97
GLY031-3 · 97
GLY032-1 · 98
GLY032-2 · 98
GLY033-1 · 98
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OligoTech®
GLY033-2 · 99
GLY034 · 99
GLY034-AP · 143
GLY035-1 · 99
GLY035-2 · 99
GLY035-3 · 100
GLY035-4 · 100
GLY035-5 · 100
GLY036-1 · 100
GLY036-1-PR · 143
GLY036-2 · 101
GLY037-1 · 101
GLY037-1-NPR · 143
GLY037-2 · 101
GLY038-1 · 102
GLY038-2 · 102
GLY038-3 · 102
GLY038-4 · 102
GLY038-5 · 103
GLY039-1 · 103
GLY039-2 · 103
GLY040-1 · 104
GLY040-1-NPR · 144
GLY040-2 · 104
GLY044 · 108
GLY045 · 107
GLY046 · 106
GLY047 · 107
GLY048 · 106
GLY049 · 105
GLY050 · 105
GLY050-PR · 144
GLY051 · 105
GLY052 · 106
GLY053 · 108
GLY053-PR · 144
GLY054 · 106
GLY055 · 107
GLY056 · 107
GLY056-NPR · 145
GLY058-AP · 144
GLY060 · 109
GLY061 · 110
GLY062 · 110
GLY063 · 109
GLY064 · 110
GLY065 · 111
GLY066 · 109
GLY067 · 111
GLY068 · 111
GLY070 · 114
GLY071 · 112
GLY072 · 114
GLY073 · 114
GLY074-1 · 112
GLY074-2 · 112
GLY075 · 113
GLY076 · 113
GLY077 · 113
GLY078 · 113
GLY079 · 113
GLY080 · 115
GLY081 · 116
GLY082 · 116
GLY083 · 117
GLY084-1 · 115
GLY084-2 · 116
GLY085-1 · 115
GLY085-2 · 117
GLY086-1 · 115
GLY086-2 · 117
GLY090 · 119
GLY090-AP · 145
GLY090-NPR · 145
GLY091 · 119
GLY092 · 119
GLY093 · 120
GLY094 · 120
GLY094-NPR · 145
GLY095 · 120
GLY096 · 120
GLY096-AP · 146
GLY096-NPR · 146
GLY097 · 121
GLY098 · 121
GLY098-NPR · 146
GLY099 · 121
GLY100 · 121
GLY101 · 122
GLY102 · 122
GLY103 · 122
GLY104 · 122
GLY105 · 119
GLY111 · 136
GLY120 · 124
GLY120-NPR · 147
GLY121 · 124
GLY122 · 126
GLY123 · 126
GLY123-NPR · 147
GLY124 · 125
GLY125 · 125
GLY126 · 94
GLY127 · 98, 125
GLY128 · 101
GLY129 · 104
GLY130 · 126
GLY131 · 126
GLY132 · 127
GLY133 · 127
GLY134 · 114
GLY135 · 124
GLY136 · 124
GLY140 · 138
GLY141 · 138
GLY141-Aa · 148
GLY141-Ab · 148
GLY141-PR · 148
GLY142 · 138
GLY143 · 138
GLY143-Aa · 148
GLY143-Ab · 148
GLY143-PR · 148
GLY151 · 139
GLY153 · 139
GLY154 · 139
GLY155 · 139
GLY156 · 140
GLY157 · 140
GLY158 · 140
GLY159 · 140
GLY160 · 129
GLY161 · 129
GLY162 · 129
GLY163 · 130
GLY164 · 130
GLY165 · 130
GLY171 · 125
GLY172 · 116
GLY173 · 136
GLY174 · 136
GLY180 · 128
GLY181 · 128
GLY190 · 130
GLY191-1 · 131
GLY191-2 · 131
GLY192 · 131
GLY193 · 131
GLY194-1 · 132
GLY194-2 · 132
GLY195-1 · 132
GLY195-2 · 132
GLY196-1 · 133
GLY196-2 · 133
GLY197 · 133
GLY198-1 · 133
GLY198-2 · 134
GLY199 · 134
GLY200 · 134
GLY201-1 · 134
GLY201-2 · 135
GLY202-1 · 135
GLY202-2 · 135
GLY203-1 · 135
GLY203-2 · 135
GLY220-NPR · 147
GLY220-PR · 148
GLY221-Ab · 148
GLY221-AP · 147
GLY221-PR · 147
GLY222-Ab · 148
GLY222-PR · 148
GLY223-AM · 149
GLY223-PR · 149
GLY224-Aa · 149
GLY224-Ab · 149
GLY224-PR · 149
GLY225-Aa · 149
GLY225-PR · 149
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OligoTech®
H
HGL100 · 88
HGL101 · 88
L
LEC101 · 159
LEC102 · 159
LEC202 · 159
LEC301 · 159
LEC302 · 160
LEC401 · 160
LEC402 · 160
MAN213 · 64
MAN215 · 64
MAN219 · 64
MAN300 · 65
MAN400 · 65
MAN500 · 65
MAN600 · 67
MAN610 · 67
MAN700 · 68
MAN800 · 61
MAN801 · 61
MAN810 · 61
ULV003 · 44
ULV005 · 44
ULV006 · 44
ULV007 · 44
ULV010 · 43
ULV011 · 44
ULV100 · 43
ULV101 · 43
ULV102 · 43
ULV103 · 43
S
XYL100 · 51
XYL101 · 51
XYL110 · 51
XYL111 · 51
SPR100 · 86
M
MAN100 · 62
MAN200 · 64
MAN201 · 64
MAN202 · 64
164
X
U
ULV001 · 44
ULV002 · 44
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Product name index A-B
1-F-(1-β-fructofuranosyl)-2-nystose .....................................................................................84
1-F-(1-β-fructofuranosyl)-3-nystose .....................................................................................84
1-kestose (DP3) .................................................................................................................83
2’FL ..................................................................................................................................97
2’Fucosyllactose .................................................................................................................97
2'2 DiFucosyllactose ......................................................................................................... 130
3 Fucosyllactose ............................................................................................................... 109
3 Sialylgalactose .............................................................................................................. 140
3’Sialyl-3Fucosyllactose..................................................................................................... 109
3’-α-sialyl-N-Acetyl-Lactosamine ........................................................................................ 116
3-FL................................................................................................................................ 109
3-Fucosylated Blood group A tetraose ................................................................................. 111
3-Fucosylated Blood group B tetraose ................................................................................. 111
3Sialyl-Gb3...................................................................................................................... 125
3'Sialyllactose .................................................................................................................. 119
3'Sialyllactose-β-Aminopropyl ............................................................................................ 145
3'Sialyllactose-β-N-Acetyl Propargyl.................................................................................... 145
Acemannan polysaccharide (Aloe vera) .................................................................................61
Acetylated XFG xyloglucan oligosaccharide (DP7) ...................................................................16
Acetylated XLFG xyloglucan oligosaccharide (DP10) ................................................................17
Acetylated XLG oligosaccharide ............................................................................................18
Acetylated XLLFG xyloglucan oligosaccharide (DP13) ..............................................................18
Acetylated XLLG oligosaccharide...........................................................................................19
Acetylated XXFG oligosaccharide ..........................................................................................19
Acetylated XXLG oligosaccharide (XXLG(Ac)) .........................................................................18
Agar polysaccharides ..........................................................................................................58
aGM1 (asialo GM1) Ganglioside sugar ................................................................................. 122
aGM2 (asialo GM2) Ganglioside sugar ................................................................................. 122
Alginate polysaccharides (from Ascophyllum nodosum) ...........................................................71
Alginate polysaccharides (from Chorda filum) ........................................................................71
Alginate polysaccharides (from Durvillaea antarctica)..............................................................71
Alginate polysaccharides (from Fucus vesiculosus)..................................................................71
Alginate polysaccharides (from Laminaria) .............................................................................71
Alginate polysaccharides Kit.................................................................................................71
Aminoglycoside platform 1 ................................................................................................ 156
Aminoglycoside platform 2 ................................................................................................ 156
Aminoglycoside platform 3 ................................................................................................ 156
Aminoglycoside platform 4 ................................................................................................ 156
Apiogalacturonan polysaccharide (sodium salt) ......................................................................78
Arabinan polysaccharides from Apple ....................................................................................80
BC2LA from Burkholderia cenocepacia ................................................................................. 159
BC2LC-Nt from Burkholderia cenocepacia ............................................................................ 160
Blood group A antigen hexaose type 1 ................................................................................ 101
Blood group A antigen hexaose type 1-β-N-Acetyl Propargyl .................................................. 143
Blood group A antigen hexaose type 2 ................................................................................ 101
Blood group A antigen pentaose type 1 ............................................................................... 100
Blood group A antigen pentaose type 1-β-Propargyl.............................................................. 143
Blood group A antigen pentaose type 2 ............................................................................... 101
Blood group A antigen pentaose type 4 ............................................................................... 101
Blood group A antigen tetraose type 1 ..................................................................................99
Blood group A antigen tetraose type 2 ..................................................................................99
Blood group A antigen tetraose type 5 ................................................................................ 100
Blood group A antigen triaose ..............................................................................................99
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Product name index B-C
Blood group A antigen triaose-β-Aminopropyl ...................................................................... 143
Blood group A Lewisb antigen pentaose type 1 ..................................................................... 100
Blood group A LewisY antigen pentaose type 2 ..................................................................... 100
Blood group B antigen hexaose type 1 ................................................................................ 104
Blood group B antigen hexaose type 1-β-N-Acetyl Propargyl .................................................. 144
Blood group B antigen hexaose type 2 ................................................................................ 104
Blood group B antigen pentaose type 1 ............................................................................... 103
Blood group B antigen pentaose type 2 ............................................................................... 103
Blood group B antigen pentaose type 4 ............................................................................... 104
Blood group B antigen tetraose type 1 ................................................................................ 102
Blood group B antigen tetraose type 2 ................................................................................ 102
Blood group B antigen tetraose type 5 ................................................................................ 102
Blood group B antigen triaose-β-Aminopropyl ...................................................................... 144
Blood group B Lewisb antigen pentaose type 1 ..................................................................... 102
Blood group B LewisY antigen pentaose type 2 ..................................................................... 103
Blood group H antigen disaccharide ......................................................................................97
Blood group H antigen pentaose type 1 .................................................................................98
Blood group H antigen pentaose type 2 .................................................................................99
Blood group H antigen tetraose type 1 ..................................................................................98
Blood group H antigen tetraose type 2 ..................................................................................98
Blood group H antigen tetraose type 4 .......................................................................... 98, 125
Blood group H antigen triaose type 1 ....................................................................................97
Blood group H antigen triaose type 2 ....................................................................................97
Blood group H antigen triaose type 5 ....................................................................................97
CD15 .............................................................................................................................. 105
Cellobiose ..........................................................................................................................21
Celloheptaose ....................................................................................................................22
Cellohexaose .....................................................................................................................22
Cellooctaose ......................................................................................................................22
Cello-Oligosaccharides Kit....................................................................................................22
Cellopentaose ....................................................................................................................21
Cellotetraose .....................................................................................................................21
Cellotriose .........................................................................................................................21
Chitin oligosaccharide DP2 ...................................................................................................37
Chitin oligosaccharide DP3 ...................................................................................................37
Chitin oligosaccharide DP4 ...................................................................................................37
Chitin oligosaccharide DP5 ...................................................................................................38
Chitin oligosaccharide DP6 ...................................................................................................38
Chitin oligosaccharide DP7 ...................................................................................................38
Chitin polysaccharide ..........................................................................................................37
Chitinbiose ................................................................................................................ 37, 140
Chitinheptaose ...................................................................................................................38
Chitinhexaose ....................................................................................................................38
Chitin-Oligosaccharides Kit ..................................................................................................38
Chitinpentaose ...................................................................................................................38
Chitintetraose ....................................................................................................................37
Chitintriaose ......................................................................................................................37
Chitosan oligosaccharides DP12 ...........................................................................................39
Chitosan oligosaccharides DP40 ...........................................................................................39
Chitosan oligosaccharides DP6 .............................................................................................39
Chitosan oligosaccharides DP60 ...........................................................................................39
Chitosan oligosaccharides mixture ........................................................................................39
Chitosan polysaccharide ......................................................................................................39
166
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Product name index C-G
Colloidal Chitin polysaccharide .............................................................................................37
Core type 1 triaose .............................................................................................................93
Core type 2 triaose .............................................................................................................94
Core type 4 .......................................................................................................................94
Cytolipin R ....................................................................................................................... 114
DC-SIGN ECD (extra-cellular domain) ................................................................................. 160
DF-L ............................................................................................................................... 109
Difucosyllactose ............................................................................................................... 109
Difucosylpentaose ............................................................................................................ 129
Disialosylpentaose ............................................................................................................ 129
Disialyl lactose / DS-L ....................................................................................................... 119
Disialylated iGb5 analogue type 1 ....................................................................................... 135
Disialylated iGb5 analogue type 2 ....................................................................................... 135
Disialylated isoglobopentaose analogue type 1 ..................................................................... 135
Disialylated isoglobopentaose analogue type 2 ..................................................................... 135
Disialylated pentaose type 1 .............................................................................................. 116
Disialylated tetraose type 1 ............................................................................................... 115
Disialylated tetraose type 2 ............................................................................................... 117
Forssman antigen pentaose ............................................................................................... 127
Forssman antigen triaose .................................................................................................. 127
Fructofuranosyl-Nystose ......................................................................................................83
Fructo-oligosaccharide DP10 ................................................................................................84
Fructo-oligosaccharide DP11 ................................................................................................84
Fructo-oligosaccharide DP12 ................................................................................................84
Fructo-oligosaccharide DP5 ..................................................................................................83
Fructo-oligosaccharide DP6 ..................................................................................................84
Fructo-oligosaccharide DP7 ..................................................................................................84
Fructo-oligosaccharide DP8 ..................................................................................................84
Fructo-oligosaccharide DP9 ..................................................................................................84
Fructo-Oligosaccharides Kit..................................................................................................84
Fructo-oligosaccharides mixture from Jerusalem artichoke (Cut-off< 10 kDa) ............................83
F-SL ............................................................................................................................... 109
Fucoidan oligosaccharides (Cut-off<10kDa) from Ascophyllum n. .............................................48
Fucoidan oligosaccharides (Cut-off<10kDa) from Chorda filum .................................................48
Fucoidan oligosaccharides (Cut-off<10kDa) from Durvillea a....................................................48
Fucoidan oligosaccharides (Cut-off<10kDa) from Fucus vesiculosus ..........................................48
Fucoidan polysaccharide from Ascophyllum nodosum ..............................................................47
Fucoidan polysaccharide from Chorda filum ...........................................................................47
Fucoidan polysaccharide from Durvillea antarctica ..................................................................47
Fucoidan polysaccharide from Fucus vesiculosus ....................................................................47
Fucoidan polysaccharide Kit .................................................................................................47
Fucosyl GM1 Ganglioside sugar .......................................................................................... 122
Fucosylated A antigen type 5 ............................................................................................. 130
Fucosylated B antigen type 5 ............................................................................................. 130
GA1 ................................................................................................................................ 122
GA2 ................................................................................................................................ 122
Galabiose ........................................................................................................................ 139
Galactofucan oligosaccharides (Cut-off<10kDa) from Undaria pinnatifida ..................................48
Galactofucan polysaccharide from Undaria pinnatifida .............................................................47
Galactoglucomannan polysaccharide .....................................................................................68
Galactomannan oligosaccharides DP3 from Carob ...................................................................64
Galactomannan oligosaccharides DP5 from Carob ...................................................................64
Galactomannan oligosaccharides DP9 from Carob ...................................................................64
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Product name index G
Galactomannan polysaccharides from Carob (locust bean gum) ...............................................64
Galactomannan polysaccharides from Fenugreek ....................................................................64
Galactomannan polysaccharides from Guar ............................................................................64
Galactose-β-aminooxy ...................................................................................................... 148
Galactose-β-Aminopropyl .................................................................................................. 147
Galactose-β-Propargyl ....................................................................................................... 147
Galactosyl-lactose ............................................................................................................ 129
Galacturonan oligosaccharide block(OGAs) ............................................................................78
Galacturonan oligosaccharides Mixture DP3/DP4 ....................................................................78
Galacturonan oligosaccharides Mixture DP7/DP8 ....................................................................78
Galacturonate polysaccharides HM from apple (sodium salt) ....................................................77
Galacturonate polysaccharides HM from citrus (sodium salt) ....................................................77
Galacturonate polysaccharides LM from apple (sodium salt) .....................................................77
Galacturonate polysaccharides LM from citrus (sodium salt) ....................................................77
GalGalNac-aGM1 (GalGalNAc asialo GM1) Ganglioside sugar .................................................. 136
Galili antigen heptaose ...................................................................................................... 113
Galili antigen nonaose ....................................................................................................... 113
Galili antigen pentaose ...................................................................................................... 112
Galili antigen triaose ......................................................................................................... 112
Galili antigen undecaose .................................................................................................... 113
GalNAc-aGM1 (GalNAc-asialo GM1) Ganglioside sugar ........................................................... 136
GalNAcβ1-3Gal ................................................................................................................. 139
Galα1-3Gal ...................................................................................................................... 139
Galα1-4Gal ...................................................................................................................... 139
Galα1-4Galα1-4Gal ........................................................................................................... 140
Galα1-4Galα1-4Galα1-4Gal ................................................................................................ 140
Galα-3 epitope ................................................................................................................. 112
Galβ1-3Gal-α-aminooxy .................................................................................................... 149
Galβ1-3Gal-α-propargyl .................................................................................................... 149
Gb3 ................................................................................................................................. 124
Gb4 ................................................................................................................................. 124
Gb4 analogue ................................................................................................................... 130
Gb4 Globoside terminal ..................................................................................................... 139
Gb4-Lewisa analogue ......................................................................................................... 131
Gb4-Lewisx analogue ......................................................................................................... 131
Gb5 analogue type 1 ......................................................................................................... 131
Gb5 analogue type 2 ......................................................................................................... 131
Gb5 Triaose core structure ..................................................................................................94
GD1a Ganglioside sugar .................................................................................................... 121
GD1a Ganglioside sugar-β-N-Acetyl Propargyl ...................................................................... 146
GD1b Ganglioside sugar .................................................................................................... 121
GD2 Ganglioside sugar ...................................................................................................... 120
GD2 Ganglioside sugar-β-N-Acetyl Propargyl ....................................................................... 145
GD3 Ganglioside sugar ...................................................................................................... 119
Gentio-oligosaccharides mixture ...........................................................................................32
GF10 ..................................................................................................................................84
GF11 ..................................................................................................................................84
GF2 ...................................................................................................................................83
GF3 ...................................................................................................................................83
GF4 ...................................................................................................................................83
GF5 ...................................................................................................................................84
GF6 ...................................................................................................................................84
GF7 ...................................................................................................................................84
168
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Product name index G-H
GF8 ...................................................................................................................................84
GF9 ...................................................................................................................................84
GlcNAcβ1-3Gal ................................................................................................................. 139
Globo -H tetraose ............................................................................................................. 125
Globo-A........................................................................................................................... 125
Globo-B .......................................................................................................................... 125
Globo-H .......................................................................................................................... 126
Globo-H analogue type 1 ................................................................................................... 132
Globo-H analogue type 2 ................................................................................................... 132
Globo-H-β-N-Acetyl Propargyl ............................................................................................ 147
Globopentaose (Gb5) ........................................................................................................ 126
Globopentaose analogue type 1 ......................................................................................... 131
Globopentaose analogue type 2 ......................................................................................... 131
Globotetraose .................................................................................................................. 124
Globotetraose analogue..................................................................................................... 130
Globotetraose Lewisa analogue ........................................................................................... 131
Globotetraose Lewisx analogue ........................................................................................... 131
Globotriaose .................................................................................................................... 124
Globotriaose /Gb3-β-N-Acetyl Propargyl............................................................................... 147
Globotriaose analogue type 1 ............................................................................................. 124
Globotriaose analogue type 2 ............................................................................................. 124
Glucomannan oligosaccharides (Cut-off<10kDa) ....................................................................67
Glucomannan polysaccharide from Konjac .............................................................................67
Glucose-β-aminooxy ......................................................................................................... 148
Glucose-β-propargyl ......................................................................................................... 148
Glucurono-Arabinoxylan polysaccharide from wheat bran ........................................................51
Glucuronyl-Lacto-N-tetraose .............................................................................................. 128
Glucuronyl-lactose ............................................................................................................ 128
Glucuronyl-LNT ................................................................................................................ 128
GM1a Ganglioside sugar .................................................................................................... 120
GM1a Ganglioside sugar-β-Aminopropyl .............................................................................. 146
GM1a Ganglioside sugar-β-N-Acetyl Propargyl ...................................................................... 146
GM1b Ganglioside sugar .................................................................................................... 121
GM2 Ganglioside sugar ...................................................................................................... 120
GM2 Ganglioside sugar analogue ........................................................................................ 136
GM3 Ganglioside sugar ...................................................................................................... 119
GM3 Ganglioside sugar-β-Aminopropyl ................................................................................ 145
GM3 Ganglioside sugar-β-N-Acetyl Propargyl ....................................................................... 145
GQ3 Ganglioside sugar ...................................................................................................... 119
GT1a Ganglioside sugar..................................................................................................... 121
GT1c Ganglioside sugar ..................................................................................................... 122
GT2 Ganglioside sugar ...................................................................................................... 120
GT3 Ganglioside sugar ...................................................................................................... 119
Guluronate oligosaccharides DP10 (sodium salt).....................................................................72
Guluronate oligosaccharides DP20 (sodium salt).....................................................................72
Guluronate oligosaccharides DP3 (sodium salt) ......................................................................72
Guluronate oligosaccharides DP5 (sodium salt) ......................................................................72
Heparosan K5 polysaccharide............................................................................................. 152
Heparosan-derived oligosaccharide DP10 ............................................................................ 153
Heparosan-derived oligosaccharide DP2 .............................................................................. 152
Heparosan-derived oligosaccharide DP4 .............................................................................. 153
Heparosan-derived oligosaccharide DP6 .............................................................................. 153
Heparosan-derived oligosaccharide DP8 .............................................................................. 153
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Product name index H-L
High DP Cello-Oligosaccharides ............................................................................................22
HNK 1 epitope precursor ................................................................................................... 128
iGb3 ............................................................................................................................... 114
iGb4 ............................................................................................................................... 114
iGb4 analogue .................................................................................................................. 133
iGb4-Lewisa analogue ........................................................................................................ 134
iGb4-Lewisx analogue type 2 .............................................................................................. 134
iGb5 ............................................................................................................................... 114
iGb5 analogue type 2 ........................................................................................................ 134
Inulin from chicory roots .....................................................................................................83
Iota-Carrageenan polysaccharides ........................................................................................57
Isoforssman antigen pentaose ........................................................................................... 114
Isoglobo-H analogue type 1 ............................................................................................... 134
Isoglobo-H analogue type 2 ............................................................................................... 135
Isoglobopentaose ............................................................................................................. 114
Isoglobopentaose analogue type 1 ...................................................................................... 133
Isoglobotetraose .............................................................................................................. 114
Isoglobotetraose analogue ................................................................................................. 133
Isoglobotetraose Lewisa analogue ....................................................................................... 134
Isoglobotetraose Lewisx analogue type 2 ............................................................................. 134
Isoglobotriaose ................................................................................................................ 114
Isolichenan oligosaccharides (Cut-off:3<->10 kDa) ................................................................29
Isolichenan oligosaccharides (Cut-off< 10kDa).......................................................................29
Isolichenan polysaccharide ..................................................................................................29
Kappa-Carrageenan polysaccharides .....................................................................................57
LacNAc ..............................................................................................................................94
Lactodifucotetraose .......................................................................................................... 109
Lacto-N-Biose ....................................................................................................................93
Lacto-N-difucohexaose II .................................................................................................. 107
Lacto-N-fucopentaose I .......................................................................................................98
Lacto-N-fucopentaose V .................................................................................................... 110
Lacto-N-neodifucohexaose ................................................................................................. 105
Lacto-N-neofucopentaose .................................................................................................. 110
Lacto-N-neofucopentaose I ..................................................................................................99
Lacto-N-neooctaose ............................................................................................................95
Lacto-N-neotetraose ...........................................................................................................95
Lacto-N-tetraose ................................................................................................................93
Lacto-N-Triaose..................................................................................................................94
Lactose-β-aminooxy ......................................................................................................... 148
Lactose-β-N-Acetyl Propargyl ............................................................................................. 147
Lactose-β-propargyl.......................................................................................................... 148
Lambda-Carrageenan polysaccharides ..................................................................................57
Laminaran oligosaccharide mixture (<10 kDa cut-off) .............................................................27
Laminaran polysaccharide from Fucus v. ...............................................................................27
Laminaran polysaccharide from Laminaria sp. ........................................................................27
Langerin ECD (extra-cellular domain) ................................................................................. 160
LEC401 ........................................................................................................................... 160
LecA (PA-IL) from Pseudomonas aeruginosa ........................................................................ 159
LecB (PA-IIL) from Pseudomonas aeruginosa ....................................................................... 159
Lentinan polysaccharide ......................................................................................................31
Lewisa (Lea) hexaose ......................................................................................................... 107
Lewisa (Lea) tetraose ......................................................................................................... 106
Lewisa (Lea) triaose ........................................................................................................... 106
170
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Product name index L-N
Lewisb (Leb) pentaose ....................................................................................................... 107
Lewisb (Leb) tetraose ......................................................................................................... 107
Lewisb pentaose-β-N-Acetyl Propargyl ................................................................................. 145
LewisX (LeX) hexaose ........................................................................................................ 105
LewisX (LeX) tetraose ........................................................................................................ 105
LewisX (LeX) triaose .......................................................................................................... 105
LewisX tetraose-β-Propargyl ............................................................................................... 144
LewisY (LeY) pentaose ....................................................................................................... 106
LewisY (LeY) tetraose ......................................................................................................... 106
LFG oligosaccharide ............................................................................................................18
L-fucose .......................................................................................................................... 138
L-Fucose-α-aminooxy ....................................................................................................... 148
L-Fucose-α-propargyl ........................................................................................................ 148
L-Fucose-β-aminooxy ....................................................................................................... 148
Lichenan & Isolichenan polysaccharide Native grade ...............................................................29
Lichenan polysaccharide ......................................................................................................29
Linear B-2 trisaccharide .................................................................................................... 112
linear B-6 trisaccharide ..................................................................................................... 114
LNDFH II ......................................................................................................................... 107
LNFP I ...............................................................................................................................98
LNFP V ............................................................................................................................ 110
LNFP VI ........................................................................................................................... 110
LNnDFH .......................................................................................................................... 105
LnNFP I .............................................................................................................................99
LNnFP-V .......................................................................................................................... 110
LNnO ................................................................................................................................95
LNnT .................................................................................................................................95
LNT ..................................................................................................................................93
LNT2 .................................................................................................................................94
LSTa ............................................................................................................................... 116
LSTd ............................................................................................................................... 117
LS-Tetrasaccharide a ........................................................................................................ 116
LS-Tetrasaccharide d ........................................................................................................ 117
Maltodecaose .....................................................................................................................25
Maltodextrin oligosaccharide mixture ....................................................................................23
Maltoheptaose ...................................................................................................................24
Maltohexaose .....................................................................................................................24
Maltononaose ....................................................................................................................25
Maltooctaose .....................................................................................................................24
Malto-Oligosaccharides Kit ...................................................................................................25
Maltopentaose ...................................................................................................................24
Maltose .............................................................................................................................23
Maltotetraose .....................................................................................................................23
Maltotriose ........................................................................................................................23
Mannan oligosaccharides (cut-off<10kDa) .............................................................................61
Mannan polysaccharide (Ivory Nut or Tagua) .........................................................................61
Mannose-α-aminooxy........................................................................................................ 149
Mannose-α-propargyl ........................................................................................................ 149
Mannuronate oligosaccharides DP10 (sodium salt) ..................................................................73
Mannuronate oligosaccharides DP20 (sodium salt) ..................................................................73
Mannuronate oligosaccharides DP3 (sodium salt) ...................................................................73
Mannuronate oligosaccharides DP5 (sodium salt) ...................................................................73
N,N’-diacetylchitobiose ...................................................................................................... 140
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Product name index N-S
N-Acetyl-D-Lactosamine ......................................................................................................94
N-acetylgalactosamine ...................................................................................................... 138
N-acetylgalactosamine-α-aminooxy .................................................................................... 148
N-acetylgalactosamine-α-propargyl .................................................................................... 148
N-acetylgalactosamine-β-aminooxy .................................................................................... 148
N-acetylglucosamine-α-aminooxy ....................................................................................... 149
N-acetylglucosamine-β-aminooxy ....................................................................................... 149
N-acetylglucosamine-β-propargyl ....................................................................................... 149
N-acetylmannosamine....................................................................................................... 138
N-acetylneuraminic acid .................................................................................................... 138
neo-LNT ............................................................................................................................95
Nystose (DP4) ....................................................................................................................83
P antigen ......................................................................................................................... 124
P1 antigen ....................................................................................................................... 124
Para-Lacto-N-neohexaose....................................................................................................95
Para-LNnH .........................................................................................................................95
Pk antigen........................................................................................................................ 124
Pk antigen-β-N-Acetyl Propargyl ......................................................................................... 147
Pustulan polysaccharide ......................................................................................................32
Quadrisialyl lactose ........................................................................................................... 119
Reduced LFG......................................................................................................................19
Reduced XFG xyloglucan oligosaccharide (DP7) ......................................................................15
Reduced XLFGG oligosaccharide (XXLGol) ..............................................................................19
Reduced XLLFG xyloglucan oligosaccharide (DP13) .................................................................17
Reduced XLLG oligosaccharide .............................................................................................19
Reduced XXFG oligosaccharide .............................................................................................19
Reduced XXLG oligosaccharide (XXLGol) ...............................................................................18
Rhamnogalacturonan polysaccharide from gombo (sodium salt) ...............................................78
RSL from Ralstonia solanacearum ....................................................................................... 159
Scleroglucan polysaccharide ................................................................................................30
Sialic acid ........................................................................................................................ 138
Sialyl Le x precursor .......................................................................................................... 116
Sialyl Lea precursor ........................................................................................................... 115
Sialyl Lewisa (sLea) tetraose ............................................................................................... 108
Sialyl LewisX (sLeX) pentaose ............................................................................................. 108
Sialyl LewisX (sLeX) tetraose .............................................................................................. 107
Sialyl LewisX pentaose-β-Propargyl ..................................................................................... 144
Sialylated globotriaose ...................................................................................................... 125
Sialylated iGb5 analogue type 1 .......................................................................................... 135
Sialylated iGb5 analogue type 2 .......................................................................................... 135
Sialylated isoglobopentaose analogue type 1 ....................................................................... 135
Sialylated isoglobopentaose analogue type 2 ....................................................................... 135
Sialylated tetraose type 1 .................................................................................................. 115
Sialylated tetraose type 2 .................................................................................................. 116
Sialylated triaose type 1 .................................................................................................... 115
Sialylated triaose type 2 .................................................................................................... 116
Sialylated-SSEA-4 hexaose analogue type 1 ........................................................................ 133
Sialylated-SSEA-4 hexaose analogue type 2 ........................................................................ 133
Sialyl-lacto-N-tetraose a.................................................................................................... 116
Sialyl-lacto-N-tetraose d ................................................................................................... 117
Spirulan polysaccharides Fine Grade .....................................................................................86
SSEA-1 ........................................................................................................................... 105
SSEA-3b-β-N-Acetyl Propargyl ........................................................................................... 147
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Product name index S-X
SSEA-4 hexaose ............................................................................................................... 126
SSEA-4 hexaose analogue type 1 ....................................................................................... 132
SSEA-4 hexaose analogue type 2 ....................................................................................... 132
SSEA-4 tetraose ............................................................................................................... 126
Stage Specific Embryonic Antigen 3a (SSEA-3a) ................................................................... 126
Stage Specific Embryonic Antigen 3b (SSEA-3b)................................................................... 126
Stage-Specific Embryonic Antigen-4 ................................................................................... 126
Starch ...............................................................................................................................25
Sulfated Arabinogalactan oligosaccharides (Cut-off: 3kDa<->10kDa) .......................................55
Sulfated Arabinogalactan oligosaccharides (Cut-off<10kDa) ....................................................55
Sulfated Arabinogalactan oligosaccharides (Cut-off<3kDa) ......................................................55
Sulfated Arabinogalactan polysaccharide (from Codium f.) Fine grade .......................................55
Sulfated Arabinogalactan polysaccharide (from Codium f.) Native grade ....................................55
Sulfated heteropolysaccharides fine grade .............................................................................88
Sulfated heteropolysaccharides native grade..........................................................................88
Sulfated Xylomannan polysaccharides ...................................................................................62
TF antigen analogue-α-aminooxy ....................................................................................... 149
TF antigen analogue-α-propargyl ........................................................................................ 149
Tn antigen analogue-α-propargyl........................................................................................ 148
Tn antigen analogue-β-aminooxy ....................................................................................... 148
Trisialyl lactose ................................................................................................................ 119
Trisialylated pentaose type 1 ............................................................................................. 115
Trisialylated pentaose type 2 ............................................................................................. 117
Ulvan oligosaccharides (cut-off: 1<->3kDa ) from Enteromorpha sp. ........................................44
Ulvan oligosaccharides (cut-off: 1<->3kDa ) from Ulva sp.......................................................44
Ulvan oligosaccharides (cut-off: 3<->5kDa) from Enteromorpha sp. .........................................44
Ulvan oligosaccharides (cut-off: 3<->5kDa) from Ulva sp. ......................................................44
Ulvan oligosaccharides (cut-off: 650 Da<->1kDa) from Enteromorpha sp .................................44
Ulvan oligosaccharides (cut-off: 650 Da<->1kDa) from Ulva sp. ..............................................44
Ulvan oligosaccharides (cut-off<10kDa) from Enteromorpha sp. ..............................................44
Ulvan oligosaccharides (cut-off<10kDa) from Ulva sp. ............................................................43
Ulvan polysaccharides from Enteromorpha sp. Fine grade........................................................43
Ulvan polysaccharides from Enteromorpha sp. Native grade ....................................................43
Ulvan polysaccharides from Ulva sp. Fine Grade .....................................................................43
Ulvan polysaccharides from Ulva sp. Native grade ..................................................................43
Xanthan gum polysaccharide ...............................................................................................34
Xeno antigen type 1 ......................................................................................................... 112
Xeno antigen type 2 ......................................................................................................... 112
Xeno Lewisa ..................................................................................................................... 113
Xeno lewisX...................................................................................................................... 113
XFG xyloglucan oligosaccharide (DP7) ...................................................................................15
XFG(Ac) ............................................................................................................................16
XFGol ................................................................................................................................15
XLFG xyloglucan oligosaccharide (DP10) ...............................................................................16
XLFG(Ac) ...........................................................................................................................17
XLFGG oligosaccharide ........................................................................................................19
XLG oligosaccharide ............................................................................................................18
XLLFG xyloglucan oligosaccharide (DP13) ..............................................................................17
XLLFG(Ac) .........................................................................................................................18
XLLFGol ............................................................................................................................17
XLLG oligosaccharide ..........................................................................................................19
XXFG oligosaccharide ..........................................................................................................19
XXLG oligosaccharide ..........................................................................................................18
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OligoTech®
Product name index X-α
Xylan oligosaccharides XOs (cut-off: 650Da<->3kDa) from Palmaria p. ....................................51
Xylan oligosaccharides XOs (Cut-off<10kDa) from Palmaria p. .................................................51
Xylan polysaccharide from Palmaria palmata..........................................................................51
Xyloglucan oligosaccharides .................................................................................................15
Xyloglucan oligosaccharides available upon request ................................................................18
α1-3 galactobiose ............................................................................................................. 139
α1-3Galactosyl-3Fucosyllactose .......................................................................................... 110
α1-4 galactobiose ............................................................................................................. 139
α1-4Gal-3Fucosyllactose ................................................................................................... 111
α-Digalactosyl mannopentaose .............................................................................................65
α-galactosyl Mannobiose & Mannotriose ................................................................................65
α-galactosyl Mannotriose .....................................................................................................65
α-Gal-Lewisa .................................................................................................................... 113
α-Gal-LewisX .................................................................................................................... 113
174
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OligoTech®
Sale Terms & Conditions
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OligoTech®
Glycoproducts for life sciences
Engineering and production
OligoTech
®
Sale Terms and Conditions (1/2)
These conditions apply to all sales of goods by Elicityl (The Seller) to any Purchaser (The Buyer), whatever is
the nationality of the Buyer. In placing its order with the Supplier, the Buyer has accepted all of the general
terms & conditions of sale as described herein, notwithstanding any proposed change in terms contained in its
own purchasing documents.
Ordering. We will only accept orders from Companies, Universities and Colleges, Research Institutes,
Hospitals, Government Agencies. We cannot supply retailers, wholesalers, brokers or individuals. The Buyer
agrees that the Products sold and delivered to the Buyer hereunder are to be used solely for Buyer's proper
use and are not to be resold or used by customer for any other purpose or in any other manner whatsoever.
Buyer’s orders are thereafter subject to our written acceptance, and, prior to such acceptance, may be
refused or canceled by us for any reason, including our inability to supply, or if the customer could not be
identified.
Orders may be placed by mail, fax, e-mail, through our website (www.elicityl-oligotech.com). Orders should
be accompanied by a delivery and invoicing address, a Purchase Order Number, a confirmation of the
acceptation of the price of products, delivery cost and our present Terms and Conditions. Elicityl validates the
order by sending an acknowledgement receipt of order. Ordering by e-mail at [email protected]. Ordering by
fax on +33 (0)4 76 45 59 50. Customers can order by mail to the following address: Elicityl, 746 avenue
Ambroise Croizat, F-38920 Crolles, France.
Products. Our products are supplied solely for research purpose and for use in the laboratory by experienced
and qualified personnel. They are not intended for human consumption; in particular they are not for
nutritional, drug use or human experimentation. They are not intended for resale. Any other use has to be
approved and confirmed in written by Elicityl.
All or products should be handled by qualified personnel only; trained in laboratory procedures, and familiar
with potential hazards. Information is not available on the possible hazards of many compounds. The absence
of a warning must not be interpreted as indication of safety. The ultimate responsibility for the proper
handling of any product lies with the user.
Prices. All prices are listed in Euros. Duty, applicable taxes, freight charges and any special packaging
charges are excluded and will be added to the invoice. Products and prices are correct at the time of printing
and order on the web site but are subject to change without notice. The prices payable for the goods shall be
those contained in the Seller’s price list current at the time of dispatch, or confirmed on request by the Seller.
Quotations are valid for 60 days from the date on the quotation. Prices for orders placed after this period must
be re-confirmed by the Seller. We overcharge transportation cost and any applicable taxes to the customer.
Local custom fees and VAT will be separately invoiced by Transport Company or forwarding agent.
Payment. Prepaid orders (credit card or checks): Elicityl generally ships the product within two open days,
customer receiving the product within one week (Europe) to two weeks when the stock is available. See also
Availability.
Credit orders: For new customers, credit acceptance has to be confirmed by Elicityl prior to shipment. Our
payment terms are usually within 30 days of the date of invoice. Payment may be made in Euros by Credit
Card through Paypal, electronic transfer or cheque to Elicityl or to our current factoring agent, as mentioned
on the invoice. We will not accept deduction of the customer’s own bank charges. Unpaid balances shall be
subject to interest at the rate of 3 times the French applicable legal rate from the invoice date. In addition,
the Supplier may, after giving eight (8) days written notice, suspend the supply of any Products without
liability until all past due accounts (including fees and accrued interest) have been paid. The Supplier does no
pay any rebate for early payment.
Data Sheets. All orders dispatched will be accompanied by product data sheets. The specifications are made
on the base of our best knowledge and the seller shall have no liability for any deviation from this. The seller
accepts no liability for any errors. To complete the data sheet and in accordance with the regulation, the
Buyer shall provide assistance to the Supplier in connection with the collection of Information in connection
with the Products complete and deliver on first request, a “Information Form” provided by the Supplier.
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OligoTech®
Glycoproducts for life sciences
Engineering and production
OligoTech
®
Sale Terms and Conditions (2/2)
Shipping. Delivery dates mentioned in any quotation, acknowledgement of order or elsewhere are
approximate only and not of any contractual effect and the Seller shall not be under any liability to the Buyer
in respect of any failure to deliver on any particular date or dates. In case of inability of the Seller to deliver
the products eight (8) weeks after the Purchase Order, the Buyer will be informed. Small orders will be sent
by mail or registered mail. Most orders will be sent by international registered courier. The Buyer shall meet
the cost of any special packaging requested by the Buyer for any packaging rendered necessary for delivery
by any means other than the Seller’s normal means of delivery. Whenever authorizations concerning import,
exchange transactions or other formalities are required for the importation of our Products into the country of
destination, or for the payment thereof, the obtaining of such authorizations and compliance therewith within
the applicable time period is at the sole expense and complete responsibility of the Buyer. Partial shipment:
In the event that a complete order cannot be shipped, a partial shipment will be made at our discretion.
Customer must indicate at the time an order is placed in the event that a partial shipment is not acceptable.
An invoice will be processed for each partial shipment. Shipping fees will be invoiced only once, on the first
invoice.
Storage. Our products are mainly sold as freeze dried. Most products are stable for some years at ambient
temperature, provided they are not opened and the seal is not broken.
Variation. The Seller shall be determined to have fulfilled its contractual obligations in respect of any delivery
though the quantity may be up to 10% more or less than the quantity specified in the contract and in such
event the Buyer shall pay for the actual quantity delivered.
Availability. Some products require lengthy re-make periods and sometimes are derived from raw materials
which have uncertain or intermittent availability. They may therefore be unavailable for considerable periods
of time. The buyer cannot drive any right from any delay, which is no longer than two months (one month in
case of prepayment). Thereafter, the buyer’s rights are limited to cancellation of the undelivered part of the
order, prepayments are refunded.
Distribution. Some products could be delivered by local distributors. In this case the Seller informs the
Purchaser of the name and the contact of the distributor.
Warranty. In case of proven default in a product or delivery, the Seller’s responsibility cannot exceed the
replacement of the delivered product by a conform one. The Supplier shall not in no event be liable for any
lost, damage, delay, costs, diminished profits, revenues, or opportunities; or any other incidental, special,
indirect, or consequential damages of any kind or nature whatsoever arising from the contract supported by
the Buyer. Buyer must notify the Seller within five days after the products have been received or such
products shall be deemed to have been accepted. Any return of product is subject to prior agreement between
the Buyer and the Seller. Any product return without such agreement will be kept in custody and will not give
rise to any reimbursement. All costs and expenses connected to such return will be charged to the Buyer.
Intellectual Property. The Buyer shall not use the Seller’s Intellectual Property Rights in a manner that
disparages the other party or its products or services, blurs, dilutes or otherwise diminishes the Seller's trade
names, trademarks, service marks or other intellectual property, or portrays the Seller or its products or
services in a false, competitively adverse or poor light. The Buyer shall comply with the Seller's requests as to
the use of the Seller’s Property Rights and will avoid any action that diminishes the value of such marks.
Without limiting the foregoing, the Buyer shall not, without written permission from the Seller use any of the
Seller's brand names, keywords or derivations of either of the above for any purpose.
Governing Law. This contract shall be governed in all respects by the French laws and the parties hereby
submit to the jurisdiction of the Grenoble Court.
Derogation. Any derogation to these terms and conditions are specified in written in the quotation signed by
Elicityl.
These Sale Terms and conditions are subject to change without notice.
178
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746 avenue Ambroise Croizat
F-38920 Crolles - France
tel: +33 (0) 4 76 40 71 61
fax: +33 (0) 4 76 45 59 50
[email protected]
www.elicityl-oligotech.com
SA à Directoire et Conseil de Surveillance
Siret: 442 055 893 00022. Code APE: 7211Z
Intra-community VAT number: FR 844 420 558 93
© 2012 Elicityl SA. All rights reserved. Oligotech Product catalogue 4th Edition, July 2012.
Printed on 100% recycled paper with vegetable-based inks
Imprimerie Notre-Dame France