Informative notes for qualified persons in the medical field, related to "ActiMaris®" gel and solution containing: literature & research application & usage Literature & research What is ActiMaris® and how is it made? Thanks to a newly developed technology by the scientific team of QuantumMedis, so-called atomic, nascent or active oxygen (O1) is bound and stabilized to seawater. Here atomic oxygen (O1) is inserted between the sodium and the chloride atom, so that only in contact with solid matter, such as skin or mucous membrane, activated oxygen frees itself and proceeds with its activity. (This is not the same as the industrial hypochloride!) As it is above already mentioned, there are different terms for this "split" oxygen atom (O1): "atomic", "activated" and/or "nascent" oxygen. In Latin also "oxigenii in statu nascendi", plainly translated: "Oxygen in a new-born state". The new-born or activated oxygen can also be created by separating out of an ozone molecule O3 in O2 and O or out of an oxygen molecule O2 in O+O through physical influence like UV-light or electrical discharge. The creation of ozone O2+O=O3 or oxygen from the air O+O=O2 are also natural reactions. Such processes happen in nature daily every second, billions of reactions. Activated oxygen is very "active" as its name states it, and therefore it has a strong tendency to connect and react with nearby atoms or molecules by exchanging electrons. It has a very strong «redox» potential. Activated, atomic or nascent oxygen is not a new discovery, because this is also in fact the active agent in medical ozone therapy, which has successfully been applied for more than l00 years for all possible indications. According to The German Medical Association there is more than 5,5 million registered applications, that have been documented and estasblished by treating as many as 500.000 patients with ozone, hence activated oxygen. Side effects have been as low as 0,000005 % ! There are no documented studies, where there is such a low percentege in side effects. This is not unusual if you consider that activitated oxygen is a very important part of life that happens in and around us. Published text in "The Cosmetic Journal" Nr. 2, February 5th l99l, by Dr. Klaus Gaebelein The activated Oxygen Nowadays there is the possibility by means of ozone technology to get activated oxygen into natural oils and other plant outputs - a process that is again constantly present in traces, in free nature. An idea, that such additives in traces also could be used for skin care, is new, and especially therefore attractive, when in this area the therapies have showed good results in observations. The first critic was: What brings us the activation of oxygen, what happens in case of overdosing, is it in a general sense necessary to improve skin nutrition? Well, over the years this has been tested, some opinions have been stated about the interaction with bacteria and viruses, but it demanded as well some dermatological opinions. Particularly the metabolic exchange with oxygen has been researched on the level of knowledge at that time, and finally a conclusion was underlined that it could be useful for the skin to be supported by such a common natural agent. Here must be fundamentally presupposed that the activitated oxygen has always been a part of our cellular exchange cycle. Every inhaled oxygen(O2) is delivered through the circulation, but is "activated" just before the oxydation-process, so that the oxygen radicals can step into function. A great deal of these radicals are in function for the oxydation of nutritional matter, but a minor part is connected to proteins and allow to appear as important ferments, catalases, decarboxylases and hundreds of peroxydases, without which life cannot function. The activated oxygen is not a new discovery of the mentioned procedure, but it is still plays a constitual part in the evolution and existance of life. Once Warburg said that the cancer problem can only be a result of a disturbed oxygen exchange in the cell, where in case of cancer and sarcoms, in the sick tissues these peroxydic substances are totally missing. So there are people who are just short of, or miss these peroxydic substances, and therefore they get ill in one way or another. Critical Control Apart from these for life important free oxygen radicals, there are also other peroxydes,whose condition of radical activity is too agressive, so they "oxydate" too strongly. One very often harmful component, which we meet daily in our life, brings us the sun light. But particularly aggressive to the skin has shown to be the industrial peroxyde, and also hydrogen peroxyde itself. Therefore we must determin if we have a medical or cosmetic preparation that is friendly to human cells, or a very aggressive peroxyde. (See the lab safety tests for „ActiMaris®“). Finally it can be stated, that the activated oxygen is a fully valuable enrichment for skin care, if its activity is tested. Publishing continued in "The Cosmetics Journal"" Nr. 2 from February l99l The Activated Oxygen by Dr. Klaus Gaebelein The dissolvement of nutritional matter in our body is only possible if oxygen from the air is activated in our cells. Oxygen from the air is not activated yet when it binds itself to haemoglobin. The first activation happens through the mitochondrial ferments, where temporarly the toxic hydroperoxyde is built. Now through the simultaniously existing and dissolving proteins, there occurs a binding with hydroperoxydes, resulting in the creation of biological highly valuable enzymes, peroxydases like catalase, decarboxylase and many other peroxydes, without which dissolving of protein and the generation of new energy would not be granted. Recently it was established that even 3 % of haemoglobin and urinary acid are submitted to this severe oxydation process. Besides, one can proove that by the oxydative dissolvement of cholesterol also the important sexual hormones are synthesized. Therefore we can conclude that there is quite an importance in a properly functioning peroxydic system. This oxydative potential is caused by a peroxyde-bridge, where two oxygen atoms are linked in one molecule. Now there are also bonds within the biological environment that can implement oxydative strength without peroxydic bridges and in a softer intensity. A good example is vitamin C, because it can take over an oxydative quality of a peroxydase and pass it on in a softer form. And such mild oxydative agents can remain longer in the organism before they start acting. Now the question puts itself: Can also artificially created peroxydes, for preserving or also for revival of tissue, for example burnt skin, restore and animate growth? This question can be answered with a «Yes», if we first determin the safety of a preparation and confirm that there is no hazardous potential to endanger cells by the oxydation process. Lab tests for safety and efficiency Lab tests have been carried out with Confarma Ltd., represented in Switzerland, France and Germany, in the period from April to June 2006. Confarma Ltd. is listed by Swissmedic (the Swiss FDA). ActiMaris® has been tested for efficiency as a disinfectant, for cytotoxicity (L 929-proliferation), and for irritation potential on the skin and mucous membrane. (studies can be seen on our FTP-server) Summary: ------------Laboratory and clinical studies have confirmed, that the ActiMaris® substance (gel&solution), have a very wide spectrum of antiseptic action (bacteria,viruses and fungi), while there is no skin irritation potential, no mucous membrane irritation potential and even no cell toxicity potential. At the same time it showed a significant shortening of the bleeding and coagulation time when cuts were treated. Clinical studies confirmed the ability, only after few weeks, that ActiMaris® can close even chronic, diabetic and necrotic wounds. For the wide spectrum of application see following pages. ActiMaris® ---------------------- *Sea water + activated oxygen *Clean sea water (3g salt/litre or 3%); the sea salt comes from the Croatian island of Pag and is extracted by the old celtic tradition and skill, namely by means of wind and sun. The extracted sea salt is again dissolved in distilled water. Now the pure sea water is enriched with activated oxygen and stabilized, so that only upon contact with solid matter, like skin or mucous membrane, the activated oxygen is released and proceeds its wide spectrum of action. We are very proud of this technology, because we have developed a natural substance which shows the widest spectrum of antibacterial, antiviral and fungicidal activity and at the same time it shows no toxicity for human cells and no irritation potential for skin and mucous membrane. At the same time ActiMaris® shows a clinically confirmed shortening of bleeding and coagulation time. ActiMaris® finds its application in a very wide field: - Cosmetics Dermatology Gynaecology Surgery ENT Dental medicine Wound management Veterinary medicine On the following pages you can find more detailed application instructions for the above mentioned fields. Cosmetics - Before and after microdermabrasion Acne, furuncles, blackheads (pimples), irritated skin and redness All sorts of skin and nail fungi After depilation and shaving(disinfects,reduces redness and irritation) For disinfection after manicure and pedicure Before and after piercing (prevents infections) Shortens bleeding and coagulation time Has a cooling effect After treatment by a Diode laser or an IPL Dermatology - All sorts of skin fungi and scaly eczems Viral skin disease, like warts Allergies and irritations of the skin Apply on cuts and scratches For burns (cools), prevents blistering Shortens bleeding time and disinfects open wounds Speeds up healing process of infected open wounds Relieves symptoms of psoriasis, eczema and neurodermitis Relieves all kind of insect stings and bite wounds Relieves itching Gynaecology - Vaginitis Candida HPV (human papilloma virus) Herpes genitalis All kinds of bacterial, viral and fungal infections Surgery - Before and after a surgical operation Maintains and speeds up wound healing Shortens bleeding and coagulation time Reduces swelling and haematoms Disinfection of skin surface and open wounds Disinfection of catheters, instruments and endoscopical optics For treatment of haemorrhoids ENT - Stuffed, running and crusty nose In case of nose bleeding For allergic rhinitis as complementary treatment As supportive therapy for rhino-sinusitis Different forms of glossitis Bacterial, viral or fungal infections Reduces swelling Removes infections from mouth and pharynx Applied intra- and postoperatively Dental medicine - Can be used as mouth wash Gingivitis Bleeding gums Parodontitis, aphtae Disinfection of mouth cavity Disinfection of tooth pockets For tooth cleansing and hygene Wound management - Ulcus cruris Decubitus Necrotic open wounds Infected open wounds Has anti-inflammatory properties Open wounds from diabetes Bruised and swollen spots Burns, cuts and stab wounds VETERINARY MEDICINE The same indications as in humane medicine. Application / Instruction: ActiMaris® may be applied several times a day on the skin, mucous membrane and open wounds. If necessary a plaster, gauze or a bandage may be put on the treated place. In comparisson with iodine or alcohol it does not burn, but sensitive people can feel a slight burning sensation on behalf of the contained sea salt. No side-effects or irritations have been clinically detected. For disinfection: first clean spot, then apply ActiMaris® and leave on for at least 2-3 minutes. ActimMaris® can be used on babies, adults and the elderly. It can be also applied in veterinary medicine for pets and other animals. This preparation is intended for external application and not for digestion. In case that ActiMaris® gets onto an unwanted place, simply rinse with water. Important: Please avoid any direct contact with colored textile, because the activated oxygen herein can easely bleach colours!
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