Test 2 Slide 1 - Tissue from a zebra.
Test 2 Slide 1 - Tissue from a zebra.
Skeletal muscle
Test 2 Slide 1 - Tissue from a zebra.
Myofiber degeneration and necrosis – list
changes!
Test 2 Slide 1 - Tissue from a zebra.
Mineralization
Infiltration by phagocytes, hypertrophy of
satellite nuclei and fibroblasts
Test 2 Slide 1 - Tissue from a zebra.
Test 2 Slide1 – Tissue from a zebra.
Morphologic Diagnosis:
Skeletal muscle: Degeneration and necrosis, diffuse, severe, with
mineralization. (3 pt.)
NAME THREE POSSIBLE CAUSES: Capture myopathy, Cassia or
other toxic plant, Vit/E selenium imbalance, ionophore toxicity (3
pt.)
NAME ANOTHER LESION THAT YOU MAY FIND IN THIS
ANIMAL: Acute renal tubular necrosis with myoglobinuria (2 pt.)
O/C: (1pt.)
Hemorrhage
1
Test 2, Slide 2. Tissue from a mouse.
Test 2, Slide 2. Tissue from a mouse.
Liver
Test 2, Slide 2. Tissue from a mouse.
Cells swollen by glycogen and lipid – obscures
sinusoids.
Test 2, Slide 2. Tissue from a mouse.
Whoa!
Test 2, Slide 2. Tissue from a mouse.
Brown pigment within Kupffer cells (bile?)
Scattered hepatocellular necrosis
Test 2, Slide 2. Tissue from a mouse.
Biliary hyperplasia
2
Test 2 Slide 3 – Tissue from a dog.
Test 2 Slide 2 – Tissue from a horse.
Morphologic Diagnosis:
Liver: Degeneration, hepatocellular, diffuse,
moderate with lymphoplasmacytic cholangitis,
bile duct hyperplasia and dysplasia, and
piecemeal hepatocellular necrosis. (3pt.)
CAUSE(S): Helicobacter hepaticus (2pt.)
O/C: (1pt.)
Uterus
Test 2 Slide 3 – Tissue from a dog.
Three distinct layers to the endometrium
Test 2 Slide 3 – Tissue from a dog.
Attenuated glandular endothelium, with some
lymphocytes and plasma cells
Test 2 Slide 3 – Tissue from a dog.
Innermost layer – widely dilated endometrial glands.
Test 2 Slide 3 – Tissue from a dog.
Thick layer of collagen and fibroblasts between
innermost layers.
3
Test 2 Slide 3 – Tissue from a dog.
Intermediate layer of dilated (lower) and tortuous
glands (upper)
Test 2 Slide 3 – Tissue from a dog.
Innermost layer is tortuous glands lined by
columnar epithelium
Test 2 Slide 3 – Tissue from a dog.
Upper layer of intermediate zone with tortuous
glands
Test 2 Slide 3 – Tissue from a dog.
Innermost zone lined by tall palisading columnar
cells
Test 2 Slide 3 – Tissue from a dog.
Test 2 Slide 3 – Tissue from a dog.
Morphologic Diagnosis:
MORPHOLOGIC DIAGNOSIS: Uterus, endometrium:
Hyperplasia, pseudoplacentational, diffuse, severe. (3pt)
O/C: (1pt.)
Necrosis of innermost layer close to lumen
4
Test 2 Slide 4 – Tissue from a ferret.
Test 2 Slide 4 – Tissue from a ferret.
Lung
Test 2 Slide 4 – Tissue from a ferret.
Septal necrosis,
Test 2 Slide 4 – Tissue from a ferret.
Minimal airway inflammation, contents refluxed
from alveoli
Multifocal areas of loss of pulmonary
architecture and lucency
Test 2 Slide 4 – Tissue from a ferret.
Alveolar contents
Test 2 Slide 4 – Tissue from a ferret.
Extension of inflammation into pleura and
pleural changes
5
Test 2 Slide 4 – Tissue from a ferret.
Test 2 Slide 5 – Tissue from a black-necked swan.
Morphologic Diagnosis:
Lung: Pleuropneumonia, fibrinosuppurative,
diffuse, marked with numerous intra-and
extracellular bacilli. (3 pt)
CAUSE(s): Pseudomonas luteola (Klebsiella
OK)- full credit for either of these genera (1 pt)
O/C: (1pt.)
Kidney
Test 2 Slide 5 – Tissue from a black-necked swan.
Test 2 Slide 5 – Tissue from a black-necked swan.
Changes at all levels of the nephron
Glomerular changes
Test 2 Slide 5 – Tissue from a black-necked swan.
Test 2 Slide 5 – Tissue from a black-necked swan.
Tubular and interstitial changes
Interstitial amyloid
6
Test 2 Slide 5 – Tissue from a black-necked swan.
Test 2 Slide 5 – Tissue from a black-necked swan.
Gouty tophi
Mineralization
Test 2 Slide 5 – Tissue from a black-necked
swan.
Test 2 Slide 6 – FNA from a horse testis.
MORPHOLOGIC DIAGNOSIS:
Kidney: Glomerular amyloidosis, diffuse, global and
segmental, severe, with interstitial amyloid, chronic
interstitial nephritis, tubular degeneration, necrosis and
regeneration and rare gouty tophi.
O/C: (1pt.)
Test 2 Slide 6 – FNA from a horse testis.
Test 2 Slide 6 – FNA from a horse testis.
7
Test 2 Slide 6 – FNA from a horse testis.
Test 2 Slide 6 – FNA from a horse testis.
Test 2 Slide 6 – FNA from a horse testis.
CYTOLOGIC INTERPRETATION: Seminoma (2.5
pt)) with mild to moderate lymphocytic inflammation (0.5
pt)
O/C: (1 pt)
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