Electronic Supplementary Material (ESI) for Molecular BioSystems.
This journal is © The Royal Society of Chemistry 2014
Table 4: Identified proteins in microvesicles from activated VSMCs
Paragon Score
10
36,41
29,45
%Cov(95)
50,59
19,82
36,91
Accession
P10668
P26234
P79385
Entry Name
COF1_PIG
VINC_PIG
MFGM_PIG
2
24,29
4,619
19,05
Q9GKE8
Q9GLP0
CD47_PIG
ITB1_PIG
2,96
10,69
3,432
24,94
A5A8V7
P28491
HS71L_PIG
CALR_PIG
6,33
18,7
P34935
GRP78_PIG
8,01
7,75
2,01
2
8,04
43,9
6,965
2,991
12,38
20,76
P62936
Q29092
B6CVD7
P82460
Q5S1U1
PPIA_PIG
ENPL_PIG
ERO1A_PIG
THIO_PIG
HSPB1_PIG
1,44
1,49
2,771
2,449
P29797
P37176
GNAS_PIG
EGLN_PIG
2
2,03
8,901
4,493
Q007T2
Q6RVA9
CDC42_PIG
CAV1_PIG
1,28
16,36
82,65
14,52
2
22,5
6
6,859
25,69
74,88
28,09
30,95
17,49
22,66
A0PFK7
P02540
P02543
P02554
P21753
P26042
P29269
CAPZB_PIG
DESM_PIG
VIME_PIG
TBB_PIG
TYB10_PIG
MOES_PIG
MYL9_PIG
Name
Cofilin-1
Vinculin
Lactadherin
Leukocyte surface antigen
CD47
Integrin beta-1
Heat shock 70 kDa protein
1-like
Calreticulin
78 kDa glucose-regulated
protein (Fragment)
Peptidyl-prolyl cis-trans
isomerase A
Endoplasmin
ER 1-like protein alpha
Thioredoxin
Heat shock protein beta-1
Guanine nucleotidebinding protein G(s)
subunit alpha
Endoglin
Cell division control
protein 42 homolog
Caveolin-1
F-actin-capping protein
subunit beta
Desmin
Vimentin
Tubulin beta chain
Thymosin beta-10
Moesin
Myosin regulatory light
Peptides(95%)
5
20
15
Biological
Processes
CA
CA
CA
Cellular
localizatio
Cyt /Nucleus
Cyt /Membr
Sec/Membr
SecretomeP
Sec nc
NP
Sec nc
1
18
CA
CA
Membr
memb
Sec nc
NP
Exo
2
7
CH
CH
Cyt
ER
NP
NP
Exo
Exo
4
CH
ER
Sec nc
5
4
1
1
4
CH
CH
CH/MP
CH/MP
CH/MP
Sec
ER
ER
Sec/Nucleus
Cyt /Nucleus
NP
Sec c
Sec c
Sec nc
Sec nc
1
1
CS
CS
Membr
Membr
Sec nc
Sec c
Exo
1
1
CS
CS
Membr
Golgi
Sec nc
Sec nc
Exo
2
17
61
8
1
13
3
Cyt Org
Cyt Org
Cyt Org
Cyt Org
Cyt Org
Cyt Org
Cyt Org
Cyt
Cyt
Cyt
Cyt
Cyt
Cyt /Membr
Cyt
Sec nc
Sec nc
Sec nc
Sec nc
Sec nc
Sec nc
Sec nc
Exocarta
Exo
Exo
Exo
Exo
Exo
Exo
Exo
Exo
Exo
17,6
12,01
32,39
50,98
P42639
P60662
TPM1_PIG
MYL6_PIG
15,69
40,72
P67937
TPM4_PIG
38,26
2
53,04
4,713
P68137
Q08092
ACTS_PIG
CNN1_PIG
2
6,02
35,76
16,68
2,21
3,497
16,62
47,99
31,52
31,81
Q29221
Q2XVP4
Q6QAQ1
Q767L7
Q95274
CAZA2_PIG
TBA1B_PIG
ACTB_PIG
TBB5_PIG
TYB4_PIG
4,74
10,04
3,49
6
5,026
5,296
14
35,55
O02668
P15145
P20112
Q49I35
ITIH2_PIG
AMPN_PIG
SPRC_PIG
LEG1_PIG
8,01
7,647
D2WKD8
AT1A2_PIG
28,64
4
2,38
15,18
35,64
25
P05024
P0CG68
P46405
AT1A1_PIG
UBC_PIG
RS12_PIG
4
22,66
P63053
RL40_PIG
4
26,96
Q29315
RLA2_PIG
4,02
11,28
Q29371
TPIS_PIG
0,46
0,913
A8I499
CTR2_PIG
6,13
12,9
P00355
G3P_PIG
polypeptide 9
Tropomyosin alpha-1
chain
Myosin light polypeptide 6
Tropomyosin alpha-4
chain
Actin, alpha skeletal
muscle
Calponin-1
F-actin-capping protein
subunit alpha-2
Tubulin alpha-1B chain
Actin, cytoplasmic 1
Tubulin beta chain
Thymosin beta-4
Inter-alpha-trypsin
inhibitor heavy chain H2
Aminopeptidase N
SPARC
Galectin-1
Sodium/potassiumtransporting ATPase
subunit alpha-2
Sodium/potassiumtransporting ATPase
subunit alpha-1
Polyubiquitin-C
40S ribosomal protein S12
Ubiquitin-60S ribosomal
protein L40
60S acidic ribosomal
protein P2
Triosephosphate
isomerase
Low affinity cationic amino
acid transporter 2
Glyceraldehyde-3phosphate dehydrogenase
10
7
Cyt Org
Cyt Org
Cyt
Cyt
Sec nc
NP
Exo
9
Cyt Org
Cyt
NP
Exo
40
1
Cyt Org
Cyt Org
Cyt
Cyt
Sec nc
Sec nc
Exo
1
5
37
9
1
Cyt Org
Cyt Org
Cyt Org
Cyt Org
Cyt Org
Cyt
Cyt
Cyt
Cyt
Cyt
NP
NP
NP
Sec nc
Sec nc
5
5
3
4
ECM & rel
ECM & rel
ECM & rel
ECM & rel
Sec
Membr
ECM/Sec
ECM
Sec c
sec c
Sec c
NP
5
HK
Membr
Sec nc
15
2
2
HK
HK
HK
Membr
Cyt /Nucleus
Cyt
Sec nc
NP
Sec nc
2
HK
Cyt /Nucleus
Sec nc
3
HK
Cyt
NP
2
HK
Mito
NP
1
HK/MP
Membr
Sec nc
4
HK/MP
Cyt /Nucleus
Sec nc
Exo
Exo
Exo
Exo
Exo
Exo
10,27
16,58
P20303
GTR1_PIG
1,78
6,01
2,13
10,59
P23220
Q1KYT0
AT2B1_PIG
ENOB_PIG
2
2,993
P00336
LDHB_PIG
2,01
3,012
P00339
LDHA_PIG
0,35
4,411
P83686
NB5R3_PIG
4,31
2
1,34
26,4
36,32
10,94
2,576
6,897
39,87
54,28
Q9MZ16
Q767L6
P08132
P19619
P19620
VDAC1_PIG
FLOT1_PIG
ANXA4_PIG
ANXA1_PIG
ANXA2_PIG
2,01
4,188
Q29101
CXA1_PIG
2,13
4,05
4
2,472
15,6
14,29
Q6Q7J2
P01965
P02067
GDIB_PIG
HBA_PIG
HBB_PIG
2
2
27,14
18,23
12,01
2,01
2,84
2
13,89
7,86
6,802
6,848
25,36
11,34
20,37
2,838
11,4
5,156
13,77
3,675
P02101
P04246
P08835
P09571
P18648
P18650
P50447
Q29549
Q8MJ76
Q9GLP1
HBE_PIG
HBT_PIG
ALBU_PIG
TRFE_PIG
APOA1_PIG
APOE_PIG
A1AT_PIG
CLUS_PIG
FETA_PIG
FA5_PIG
Solute carrier family 2,
facilitated glucose
transporter member 1
(Fragment)
Plasma membrane
calcium-transporting
ATPase 1
Beta-enolase
L-lactate dehydrogenase B
chain
L-lactate dehydrogenase A
chain
NADH-cytochrome b5
reductase 3 (Fragment)
Voltage-dependent anionselective channel protein 1
Flotillin-1
Annexin A4
Annexin A1
Annexin A2
Gap junction alpha-1
protein
Rab GDP dissociation
inhibitor beta
Hemoglobin subunit alpha
Hemoglobin subunit beta
Hemoglobin subunit
epsilon
Hemoglobin subunit theta
Serum albumin
Serotransferrin
Apolipoprotein A-I
Apolipoprotein E
Alpha-1-antitrypsin
Clusterin
Alpha-fetoprotein
Coagulation factor V
7
HK/MP
Membr
NP
Exo
2
3
HK/MP
HK/MP
Membr
Cyt
NP
NP
Exo
1
MP
Cyt
Sec nc
1
MP
Cyt
Sec nc
1
MP
ER
NP
3
1
2
16
22
MP
Vtra/CS
Vtraf
Vtraf
Vtraf
Mito
Membr
Membr
Cyt /Nucleus
ECM/Sec
NP
NP
NP
Sec nc
Sec nc
1
Vtraf
Membr
NP
1
2
2
Vtraf
Cyt /Membr
Plasma
Plasma
NP
NP
NP
Plasma
Plasma
Plasma
Sec
Plasma
Sec
Sec
ECM
Plasma
Sec
NP
NP
Sec c
Sec nc
Sec c
Sec c
Sec c
Sec c
Sec c
Sec c
1
1
40
14
6
1
6
2
14
6
Exo
Exo
Exo
Exo
Exo
Exo