MenoStrong™
with geniVida®
ence hot flashes and/or night sweats, which are caused by the drop in estrogen levels. Science shows that genistein, the primary isoflavone found
in soy foods, can help to reduce the incidence and duration of hot flashes
and night sweats and may help lessen the discomfort of other menopausal
symptoms. Genistein belongs to a class of plant compounds called phytoestrogens and phytoestrogens functionally mimic the role that estrogen plays in our body. geniVida® has been clinically shown to reduce
hot flashes by over 50%.* geniVida®, a pure, nature identical form of
genistein, has been shown in a double blind placebo controlled randomized clinical study to help reduce both the number and duration of hot
flashes in healthy menopausal women.*
CLINICAL STUDIES:
INGREDIENTS
Genistein is one of the most abundant isoflavones in soy. Isoflavones belong to the group of flavonoids. Because of its similar structure to that of
human estrogen it is also called a phytoestrogen. Genistein has been the
focus of scientific research that have shown that it can bind to the same
receptor sites as estrogen.
Doctor’s Best MenoStrong with geniVida® effectively helps relieve menopausal symptoms.* It is a hormone-free, clinically proven product that
works safely to minimize night sweats and hot flashes in women*. It is a
menopause relief product that is free from allergens and hormones. The
active ingredient, geniVida®, which is a soy-free, pure genistein that is
formulated from a special patented process, is a powerful supplement that
works to minimize the common symptoms of menopause.* geniVida®, is
a non-soy genistein and has a chemical structure analogous to that of an
organic form of genistein.
Every year, millions of women transition into menopause causing them to
experience a variety of symptoms including vasomotor complaints, psychosomatic problems, loss of libido, joint pain, vaginal dryness and sleep
disturbances. Of all the menopausal symptoms, however, hot flashes have
been reported as the most bothersome.1, 2 Hot flashes in menopause are
a vasomotor response to a lack of estrogen and present as a feeling of
intermittent intense heat. Hot flashes are typically felt and seen as redness of the upper face, neck, and torso created by peripheral vasodilation,
increased skin temperature, and increased blood flow.1,2 These irritating
symptoms range in severity from a minor inconvenience to a major disruption in the quality of life.3,4
Most therapies designed to combat menopause-related hot flashes aim to restore hormone balance.3, 5 Because of concern over potential adverse effects of hormone therapy, alternatives have been
researched. One such alternative is genistein, a soy isoflavone
that belongs to a class of compounds known as phytoestrogens.
These phytochemicals are structurally similar to estrogen and are
BENEFITS
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MenoStrong with geniVida® helps alleviate common
menopausal symptoms*
MenoStrong with geniVida® helps reduce hot flashes and night
sweats associated with menopause*
MenoStrong with geniVida® helps reduce both the number and
severity of menopausal hot flashes*
MenoStrong with geniVida® helps improve long term bone mineral density*
Non-GMO, Soy Free, Gluten Free, Estrogen Free
During and post menopause, the estrogen levels tend to drop down in a
woman’s body triggering uncomfortable symptoms such as mood changes,
hot flashes, reduced bone density resulting in bone health issues and night
sweats as well. Doctor’s Best MenoStrong with geniVida contains genistein,
which stabilizes the reduced estrogen levels in the body and helps relieve
women from these menopausal symptoms.* The efficacy of genistein
has long been proven clinically to alleviate the menopausal symptoms in
women and in preserving the strength and composition of bone mineral.
During menopause, about two-thirds of North American women experi-
* These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.
known to interact with estrogen receptors in animals and humans3,6.
Various studies have reported that genistein significantly improves the
frequency of hot flashes when compared with placebo.1 In these studies, genistein doses ranged from 30mg to 60mg per day and duration of treatment ranged from twelve weeks to two years. There was
a mean percentage reduction in daily hot flashes from baseline ranging
from 41% to 61% with genistein in comparison with a mean reduction
ranging from 7% to 29% with placebo.1, 8, 9 Two investigations of shorter duration (twelve weeks) found no evidence that the severity or intensity of hot flashes differed between genistein and placebo groups;
but, a study of longer duration (two years) reported that hot flash
severity declined significantly when compared with placebo.1, 8, 10
Osteoporosis is a major public health problem in the elderly population affecting men and women around the world. In the United States,
over 10 million individuals have osteoporosis, and 18 million more
have low bone mass, placing them at increased risk for this disorder. 11
Women in particular are at higher risk of developing osteoporosis after menopause. Postmenopausal bone loss is caused primarily by the
sharp decrease in estrogen levels that is essential to menopause. 12, 13
In the past years, there has been an increase in the interest of the potential health effects of dietary phytoestrogens with the findings that hormone replacement therapy (HRT) is not as safe or effective as previously
thought.14 Among the numerous alternatives currently under investigation,
phytoestrogens are showing the most potential for the prevention of bone
loss and improving bone health in postmenopausal women.* 15, 16 The most
extensively studied phytoestrogen groups are isoflavones and include
genistein, structurally similar to 17β-estradiol and is considered as one of
the most potential alternative to estrogen replacement therapy. Hence
many studies have been conducted to reveal the beneficial role and the
dosage of genistein in bone protection in animal models and postmenopausal women.17, 18 Based on several studies, the optimal dose compatible with safety ranges from 12-110 mg/daily.19, 20 In several clinical trials
performed on healthy postmenopausal women, genistein helped increase
significantly the BMD (Bone Mineral Density) in that population. This study
confirms the genistein-positive effects on bone loss.*21, 22, 23
SCIENTIFIC REFERENCES
1.
Ferrari A. Soy extract phytoestrogens with high dose of isoflavones for menopausal symptoms. J Obstet Gynaecol Res
2009:35(6):1083-90.
2. Avis NE, Stellato R, Crawford S, others. Is there a menopausal
syndrome? Menopausal status and symptoms across racial/ethnic groups. Soc Sci Med 2001:52(3):345-56.
3. Williamson-Hughes PS, Flickinger BD, Messina MJ, others. Isoflavone supplements containing predominantly genistein reduce
hot flash symptoms: a critical review of published studies. Menopause 2006:13(5):831-9.
4. Freedman RR. Pathophysiology and treatment of menopausal
hot flashes. Semin Reprod Med 2005:23(2):117-25.
5. Sikon A and Thacker HL. Treatment options for menopausal hot
flashes. Cleve Clin J Med 2004:71(7):578-82.
6. Cassidy A. Physiological effects of phyto-oestrogens in relation to cancer and other human health risks. Proc Nutr Soc
1996:55(1B):399-417.
7. Lethaby A, Marjoribanks J, Kronenberg F, others. Phytoestrogens
for menopausal vasomotor symptoms. Cochrane Database Syst
Rev 2013:12:CD001395.
8. D’Anna R, Cannata ML, Atteritano M, others. Effects of the phytoestrogen genistein on hot flushes, endometrium, and vaginal
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epithelium in postmenopausal women: a 1-year
randomized,
double-blind,
placebo-controlled
study.
Menopause 2007:14(4):64855.
Evans M, Elliott JG, Sharma P,
others. The effect of synthetic genistein on menopause
symptom management in healthy postmenopausal women: a
multi-center, randomized, placebo-controlled study. Maturitas
2011:68(2):189-96.
D’Anna R, Cannata ML, Marini H, others. Effects of the phytoestrogen genistein on hot flushes, endometrium, and vaginal epithelium in postmenopausal women: a 2-year randomized, double-blind, placebo-controlled study. Menopause
2009:16(2):301-6.
http://consensus.nih.gov/2000/2000Osteoporosis111PDF.pdf
Nakamura T, Imai Y, Matsumoto T, Sato S, Takeuchi K, et al. Estrogen Prevents Bone Loss via Estrogen Receptor a and Induction of
Fas Ligand in Osteoclasts. Cell 130, 811–823, September 7, 2007.
Khosla S, Oursler MJ, Monroe DG. Estrogen and the skeleton.
Trends in Endocrinology and Metabolism November 2012, Vol.
23, No. 11.
Hays J, Ockene JK, Brunner RL, Kotchen JM, et al. Effects of estrogen plus progestin on health-related quality of life. N. Engl. J.
Med., 348 (2003), pp. 1835–1837.
Messina M. Soyfoods and soybean phytoestrogens (isoflavones)
as possible alternatives to hormone replacement therapy (HRT).
European Journal of Cancer 36 (2000) S71-S77
Kushwaha M. Role of soy isoflavones in human health. IJCBS Review Paper VOL. 1 [ISSUE 2] MAY, 2014
Setchell KD and Lydeking-Olsen E. (2003) Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo,
human observational, and dietary intervention studies. Am J Clin
Nutr. 78(suppl):593S–609S.
Miao Q, Li JG, Miao S, Hu N et al, The bone-protective effect of
genistein in the animal model of bilateral ovariectomy: Roles of
phytoestrogens and PTH/PTHR1 against post-menopausal osteoporosis. Int. J. Mol. Sci. 2012, 13,56-70
Branca F. Dietary phyto-oestrogens and bone health. Proceedings of the Nutrition Society (2003), 62, 877–887
Ma DF, Qin LQ, Wang PY and Katoh R. Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials
European Journal of Clinical Nutrition (2008) 62, 155–161
Morabito N, Crisafulli A, Vergara C et al. Effects of Genistein
and Hormone-Replacement Therapy on Bone Loss in Early
Postmenopausal Women: A Randomized Double-Blind Placebo-Controlled Study. J Bone and Mineral Res. Volume 17, Number
10, 2002
Dang ZC and Lowik C. Dose-dependent effects of phytoestrogens on bone. Trends in Endocrinology and Metabolism Vol.16
No.5 July 2005.
Zeng X, Feng Y, Yang L, et al. Single- and multiple-dose pharmacokinetics of genistein capsules in healthy Chinese subjects: A
phase I, randomized, open-label study. Current Therapeutic Research Volume 69, Issue 4, August 2008, Pages 318–333
* These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.
Doctor’s Best, Inc
phone: 800-333-6977 • fax: 949-498-3952 • www.drbvitamins.com
©Doctor’s Best, Inc. Revised 01/16