THE PROFESSOR’S FEATURES NO. 35; AUTUMN 2011 Lack of Sleep. Could it be… …the big sleeper in weight gain – and chronic disease? It’s common knowledge that lack of exercise and a poor diet are major problems in advanced countries where people should know better. But here’s another problem that seems to have slipped under everybody’s (except the Professor’s) radar – poor and or inadequate sleep. Sleep is the big sleeper when it comes to what ails us in modern health. Too little, or poor quality sleep has a direct link with Type 2 diabetes and heart disease, as well as other problems. What is not well known however is the link between poor sleep and obesity. The overweight have poor sleeping patterns, including obstructive sleep apnea (OSA) and snoring. But do poor sleeping patterns cause overweight – or is it the opposite? That’s the basis of much recent research, the results of which are so far, far from clear. To make it clearer, here’s the Professor’s rundown of the situation to date. Sleep and body weight — the latest Sleep is something we know all mammals need – although we don’t know why. It could be to restore used brain circuitry, It could be just to recover. Some sleep theorists even think that all wakefulness is just delayed sleep. The fact that the longest a human has ever gone without sleep is about 8 days, suggest that it is even more important than food. So how much do we really need? There’s a variation around a normal curve, which generally defines this. Some people need only 2-3 hours a night – but they’re the extremes. Others go for 10 or 11 hours – again, at the other extreme. On average, it’s believed we need about 7 – 8.5 hours every 24, but that after about 10 hours it becomes potentially unhealthy again. (continued on page 3) The Professor’s cunning plan for getting back to sleep Early waking is a problem for many people whose thought processes then go crazy, stopping them from getting back to sleep, and thus suffering the next day. To help overcome this it’s important understand how it happens. Sleep cycles Sleep occurs in several stages from very light to deep, then back to light. These cycles occur for up to 2-3 hours and can happen 4-5 times during the night. is recovered, it becomes easy to move from the rapid eye movement (REM), or dream state of deep sleep, to a lighter and more conscious aware state. Initially it’s difficult to differentiate between dreams and thoughts, but as consciousness increases, one thought leads to another, thus increasing the level of wakefulness. Usually in the dead of night such thoughts are also exaggerated forms of worry – about the tax bills, what the wife said yesterday, etc. The Professor’s cunning secret is to stop thoughts spiralling before they increase wakefulness to the point where it is difficult to get back to sleep. This can be done by: l Focusing, with eyes closed, on the bridge of the nose, l Concentrating on a black screen in the consciousness. Each time a thought arises, it should be left to drift off the screen and disappear, returning to the blackness or nothingness of the screen. l The sooner this occurs in early wakefulness, the quicker you’ll return to the sleep cycle and wake feeling more rested. Whether this affects weight loss or not is another matter – but let’s take things one at a time. l In the early night, when sleep debt needs to be recovered, the deep stages are stronger and longer, and the cycles are more difficult to come out of. During the early morning however, as much of that sleep Sleeping with the Professor Your commonly asked questions about sleep put to rest Is the 8-9 hours a night recommended sleep just time in bed, or deep sleep? If it was just time in bed, Charlie Sheen would be the healthiest man alive. Unfortunately, this also relates to the quality of sleep. Deep sleep is what you are after, and fewer hours of this are much more valuable than more hours of tossing and turning. Do dreams mean good or bad sleep? Generally the dream state occurs in a phase called the rapid eye movement (REM) phase of sleep, which is one of the deeper levels, so unless the dreams are nightmares or disturbing, they are an indication of good, healthy, deep sleep. Don’t knock your dreams: as far as we know you don’t have them when you’re dead. Can you recover sleep debt with short naps? The answer is ‘yes’ – and probably better with short naps (10-20 mins) than longer than this during the day. Very short ‘power naps’ on the other hand, don’t seem to work. As put by one sleep specialist, ‘the bank that deals in sleep debt doesn’t take small deposits.’ Can you sleep too much? It seems like more than about 10 hours a night’s sleep can be just as unhealthy as too little ie. less than 7 hours. But it’s difficult to know this for sure because those people who do usually sleep this long often have an illness, hence confounding the research. It does seem though that too much sleep amongst the healthy, may not help to keep them that way. If you only sleep 2-3 hours a night, with no daytime tiredness, is this a problem? As explained above there’s a wide variation in the amount of sleep needed by individuals. Some people can cope with less than 3 hours, some can cope with more than 10. In general, it’s around 7-8.5 hrs that’s required. The best measure is daytime functioning. If this is not happening properly, you’re probably not getting enough sleep. Is snoring a problem – for anyone but the sleeping partner? It is – and much more so than one might think. The gasps of air that snorers take during the night (apneas) are an attempt to regain the oxygen that’s lost through long periods of not breathing. This can raise blood pressure and indirectly affect the heart – and not in a good way. Are all snorers fat? Not all, but most. And there is a reason for this. Apart from the belly, one of the first parts of the body to gain fat is the tongue and this occludes the windpipe, causing that ZZZZZ sound. You do get lean snorers, but this is generally due to a mechanical problem which needs to be looked at by a good sleep specialist. Is it better to keep the room warm for better sleep? It’s actually better to be slightly cool. Constant air temperature is now being seen as a potential risk for weight gain because the body’s metabolism never changes. Going from warm to cool to hot to cold is something humans have done for eons. This has only changed recently since the development of air conditioning. And that must tell you something. Does it matter where you sleep? Not if it’s good quality deep sleep – it’s the quality of sleep that is important. And while your sleeping architecture might cause a stiff neck, bad back and pains in the butt. It won’t stop you from getting that well needed sleep response. Devices measure sleep quality By definition, it’s difficult for anybody who is asleep to know the quality of that sleep. You could be having hundreds of apneas, or small periods of wakefulness without knowing it, making you tired during the day. Until recently it was difficult to test this except by paying hundreds of dollars and going into a sleep clinic overnight to have a test sent back to your doctor. Technological advances have now made tests more feasible and accessible to the average person. Professor Ron Grunstein, a world acknowledged sleep expert from the Woolock Institute in Sydney has now developed the ‘Flow Wizz”, a small device attainable through your doctor on Medicare, with an attachment for the nostrils that is left on during the night. This feeds in to a computer chip, which is sent back to the Institute for analysis. The analysis is then returned to your doctor, giving a full set of data to show how deep your sleep was, when periods of wakefulness or apneas occurred, and any other problems. A more simple measure is also attainable through activity devices such as the Bodyfit Media, a new movement sensor which is worn on the arm, and which feeds movement levels back into a computer. Not only does it tell you how active you are during the day, but can show how good your sleep is at night. The cost of one of these is around $900, but can provide great results for monitoring activity levels as well as improving sleep. (continued from page 1) We know that average sleep times have dropped dramatically over the last 30 years. Eighteen percent of under 20 year-olds for example got less than 7 hours a night sleep 30 years ago, but according to the US Sleep Foundation that figure has now leapt to 36%. Why? Entertainment and development in electronics have no doubt played a major part, going back to the discovery of electricity. We know that young children who sleep less than 7 hours a night have a greater risk of obesity than those who sleep 8+ hours. But again, is this cause or effect? Obese adults suffer from sleep apnea and snore more than the lean. This leads to disruption of sleep patterns and poor sleep, but does the obesity, or the poor sleep come first? Cause and effect Many of these questions have been recently looked at through an analysis of all the existing research, or ‘metaanalysis’, on sleep and obesity. This shows that it is not the lack of sleep per se, that leads to weight gain, but the fact that lack of sleep leads to excessive day-time tiredness, which then decreases physical activity levels, which in turn, can lead to weight gain. Snoring causes several little awakenings or apneas during the night, and although the snorer may not be aware of being awake, these periods of wakefulness need to be recovered during the day. The association between lack of sleep and obesity in children could also have a confounder. If the extra waking hours are spent on passive entertainment (computer games, TV etc), this can be accompanied by extra eating (as well as lack of large movement) . As this is unlikely to be of the type recommended by the National Heart Foundation, just being awake, might thus make you fat! Summing up Irrespective of the direct causal link, there’s now clear evidence that lack of sleep is not good for body weight maintenance. Sleep deprivation can also cause a type of ‘inflammation’, which can then go on to cause type 2 diabetes. Twelve hours lack of sleep is the equivalent in driving skills reduction of a blood alcohol content of 0.05% and 24 hours of 0.1%. So driving a vehicle makes a poor sleeper a lethal weapon on the road. Which ever way you cut it, poor or inadequate sleep is unhealthy. Do political systems make you fat? It’s food and activity that make individuals fat at the individual level, but what makes whole populations fat? Although it seems to be a ‘no brainer’, it has taken some time for obesity researchers to understand the importance of the environment in determining obesity. If you have to walk to work and have to dig in the fields for food, there’s less chance of being fat than if machines do all this for you. So, how does this relate to the different political and economic systems that determine population levels of obesity? University of Sussex researchers Richard Wilinson and Kate Pickett hit on the importance of the social environment in their book ‘The Spirit Level’, when they showed that the fattest countries are those with greater inequality between the rich and the poor. Although they admit to not knowing why this is so, they say it could be due to the stress that’s created as a result of income differentials leading to greater eating and less activity ie. not venturing outdoors for fear of crime. Surprisingly, it’s the rich as well as the poor, who do worse in unequal countries like the US (and even Australia), where everyone is fatter than their equivalents in European countries. Oxford researcher, Dr Avner Offer and his associates have recently added to this by looking more deeply at the economic conditions that create obesity. Offner claims that it’s economic insecurity, rather than inequality that makes people fat, and that this comes from the different forms of market systems that dominate in a country. Using four measures of economic insecurity (security from unemployment, illness, single parent poverty, and poverty in old age), Offer found that in countries where these are highest, the population is more likely to be obese. This is the case in countries like the US, UK, Canada, Australia, NZ and Ireland. Where there is more economic security, in countries like Sweden, Norway, Denmark, Finland, Germany and France, the populations do not seem to be as fat. The question then becomes what drives economic insecurity? Economic insecurity and economic growth In some, as yet unpublished research, colleagues of the Professor have found that the gap between ‘economically secure’ and insecure countries and consequent obesity levels, only exists at the highest levels of income, or average GDP. Below this, increases in wealth do add to average body weight, but all within a healthy range. The main driver it seems, is the non-regulated drive for economic growth, beyond a point of development. As Sam Kekovitch might say: “You know it makes sense.” As we all get richer, we have to do less physical work and there is more fatty food available to eat. And if we feel insecure about keeping up with the Jones’, we actually tend to eat more and move less. So, if you really want to lose weight, eat an economist. They may not be too tasty. But you could be saving yourself – and the planet! World’s Best Contraceptive Rolled Out Hunger vs Appetite In the latest sally in the all-out war on runaway population growth, the Center for Biological Diversity has launched an apparel product guaranteed to reduce overbreeding: The new Endangered Species sockand-sandal sets, the world’s most powerful contraceptives. When it comes to issues of lifestyle, some medical workers are beyond the eight ball. Look up a medical dictionary for example for a definition of ‘hunger’ and ‘appetite’, and you’ll find basically the same thing. But look up any English dictionary definition and you’ll see they are quite different in ways that are important for anyone interested in weight control ie: The Macquarie Dictionary defines hunger as: Learning to recognise the difference and how it can help your weight “ The pain sensation or state of exhaustion caused by the need of food”, and appetite as: “A desire for food or drink.” According to the CBD, the SASS, as they call them, work by neutralizing the sex pheromones humans traditionally emit to attract mates. Studies have shown that once the sock-and-sandal sets are donned, outgoing pheromones simply drop to the floor, where they lie limp and passive and are soon trampled. Stray incoming pheromones, which may still be emitted accidentally in a low-light setting such as a bar or restaurant, cling only briefly to the wearer of the sock-and-sandal set; their half-life is short and incoming pheromones typically cease once potential mates fully perceive the presence of the sock/sandal combo. The sets -- made of recycled hybrid tires and 100-percent organic cotton grown in the shade by aging socialists -- were originally designed with men in mind, but are also available in unisex. Please note: The SASS are not effective in Tasmania. Distinguishing hunger from appetite Basically, hunger is the biological need to have to eat. It is a constant, urging drive to seek out food, which doesn’t go away with distraction. Appetite on the other hand, is a learned desire to want to eat, that develops largely through learning. It can go away when distracted (eg. if scared) and is therefore generally easier to deal with than genuine hunger when trying to reduce one’s food intake. How do you tell the difference? Genuine hunger should be rated on a scale from 1 to 8, where 1 is ‘ravenously hungry’ and 8 is ‘full to the point of wanting to throw up’. Anything beyond about 6 is likely to be genuine hunger, whereas anything less than 4 is just a learned need. Appetite develops from experience. If it is the normal experience to eat a three course meal every day at a certain time, whether hungry or not, the appetite for a meal at that time is likely to increase – irrespective of hunger. Like Pavlov’s dog, this can be de-conditioned by changing the meal, or not having the meal at that time. Snacks are probably even more importantly influenced by appetite. A cup of tea, coffee or a glass of beer for example, if accompanied by nuts, chips, or anything else that is enjoyable, will usually lead to a pairing of those two stimuli (classical conditioning). Ultimately, this means every time you have a drink, you’ll get a craving for that type of snack. Appetite is the simple one of the twin eating problems to deal with. One of the Professor’s renowned cunning plans for dealing with this is to show a supposedly hungry man, a centrefold from Playboy magazine. If hunger is still the over-riding drive, then it’s genuine. If not, it’s probably just appetite. Hunger, on the other hand, is much more difficult to deal with. Because it’s biological, it needs to be satisfied, but this can be done in all the wrong ways eg. with high, energy-dense foods. The trick is to fool the body: Foods that are high in fibre, protein, low-glycaemic index content, and even water, tend to reduce the energy, or calories taken in, whilst satisfying hunger. Summary: Tip 1 is to recognise the difference between appetite and hunger; Tip 2 is to satisfy genuine hunger with low energy-dense, filling foods. You can actually lose weight by eating more, using this method. The Professor’s Guaranteed Weight Loss programs Everyone else is doing it - selling weird and wonderful weight loss programs - and making a fortune out of it, so why not the Professor? Here are some ideas that are likely to be more effective than anything you’ll read in the women’s magazines: 1.The ‘Move-Away’ Diet: For a little over $1000 you can purchase a oneway ticket to Bangladesh, where living with the locals is guaranteed to help you lose more weight than you’ve ever dreamed of. Maintenance is not a problem – provided you never move back to a country like Australia or the US. Rating: How much more ‘natural’ a treatment can you get? 2. The ‘Messiah’ program: To date there are no respectable messiahs who have become so without a fast of at least 40 days and 40 nights in the desert. This is guaranteed to have bariatric effects, along with the psychological highs and delusions of grandeur that come from an elevated endorphin level. Long-term maintenance however is likely to be accomplished by sudden and extreme loss of friends. Rating: Good not just for this life, but also the next. 3. The ‘Smoke-like-a-chimney’ diet: It’s been castigated for it’s disadvantages, but smoking DOES aid weight loss by: 1. Increasing metabolic rate 2. Altering taste sensation, and 3. Giving you something to do with your hands. Long-term (permanent) weight loss is even more guaranteed. Unfortunately, going off the program leads to a quick rebound of ~5kg a year, but this is easily overcome by not quitting. You’ll be dead before you know it anyway. Rating: A bit drastic, but very effective. 4. The Mafia weight loss plan: Employ a Mafia hit-man to take off a finger every time you eat more than you should, or skip an exercise session. If that doesn’t work, get him to ‘waste’ one of your kids and tell your wife why it might happen. Rating: Cruel, but fair. Provided you play the game. TRIM’S TUMMY TICKLERS 5. The ‘Travel Diet’: Travel through Indonesia eating and drinking everything that looks and tastes good. It won’t be long before it all comes out the other end, with great hunks of fat from the belly, chin and other places of storage. This is likely to be coupled with the desire to never eat food again, a sure fire way of losing kilos without effort. Rating: Highly competitive on price although longterm maintenance is uncomfortable. 6. The ‘more sex’ program: Unexpectedly, this is not because of the energy burned during the act (you have to be a bedroom Olympian for this to have an impact!). The logic is more convoluted: Almost invariably, after modern western women have babies, they stack on the lard. So it stands to reason (vis. The second law of thermo-dynamics that “…energy is neither gained or lost, it just changes form”) that the act of giving a female a baby should help a man take off weight. Rating: It’s not foolproof, but it’s better than most alternatives. (In any case it’s a good chat-up line). are not all FAT Why vegetarians lean, mean FACTS and hungry looking? There’s a feeling that going vegetarian means going low energy. Hence eating just plants is likely to have a weight loss effect. But the devil is in the detail. Depending on how vegetarian foods are prepared and cooked, the energy intake may be just as high as if it came from a nonvegetarian source. Oil, ghee, lard and foods like coconut, have a high-energy content. If a vegetarian diet includes animals products, such as cheese, and these are eaten in large amounts, a vegetarian diet can be even more fattening than lots of dead animal. TRIMLINES Current conundrums in weight loss Readers of this esteemed publication, along with Donald Rumsfield, know that there are known knowns and there are known unknowns. However there are unknown knowns and…… oh bugger it. You known what we mean! And the same applies to the facts about weight loss. Here are some of the facts in the field we’re just not sure about… Does exercise overpower nutrition for weight loss in old age? Although it’s been going for some 2030 years, research into weight loss and obesity is relatively novel, and while we know the basics, there are certain questions that remain unanswered, such as changing dynamics with age. In the early years, it was promoted as doctrine that a decrease in food intake combined with an increase in exercise are equally important in the weight loss equation. But what happens as we get older? Does the relationship between exercise and nutrition stay the same? We know that gaining weight is easier with age, and keeping weight off, at least in the modern environment, more difficult. But there are physiological differences that occur with age that can alter the balance between energy intake and expenditure. Metabolic rate for example, decreases by about 2% per decade, which means that a 60 year old is burning about 10% less energy than he was at 20, just being alive. Under these circumstances, food is likely to be stored more easily in the older person as fat. On the other hand, exercise, because it raises metabolic rate, is more likely to have the opposite effect. So is exercise relatively more important for weight maintenance with age than diet? The truth is, we don’t know the answer – but it’s likely to spark a PhD thesis or two. How does bariatric, lap-banding surgery work? The idea of putting a band around the top of the stomach and restricting food intake, was originally thought to work by doing just that – reducing food intake. Then it was found to have a more subtle effect. People who had been banded tended to have less craving for food and therefore eat less soon after having the operation. It was thought that just the physical pressure of the band around the stomach wall could have an effect on hunger hormones in the brain, which reduced the genuine desire to eat. This all seemed perfectly explainable. Then some smart researcher found that these hormones actually increased in a way that would make hunger MORE rather than LESS likely. And although we know that hunger is a complex interplay between chemical levels in the brain, our knowledge to date doesn’t provide us with the answer to how lap-banding surgery works. If a calorie is a calorie, why do different types of oils have different effects on weight loss? The second law of thermo-dynamics states that energy is neither gained not lost, it just changes form. So irrespective of the form in which a calorie is consumed, it should have the same effect on body weight. Some time ago this was refuted by research that showed that men on a Mediterranean diet using olive oil, lost more weight than men on a diet of another form of equally calorific oil. And while we know that the energy balance equation is not a ‘physics’ equation, but a biological one – and hence is dependent on feedback, the reason for this, is nowhere near clear. Is it because people feel better after eating olive oil and therefore tend to become more active, hence burning up more energy? We wait in anxious anticipation for a definitive answer. Why do people respond differently to different diets? The argument has raged for the last decade or so about whether low carbohydrate, low fat, low protein or low alcohol is best for weight loss. And while it is almost impossible to predict what is best for an individual, it’s probably true that all are effective to some level in some people. There’s little doubt that the primary influence on energy intake for weight loss, is the total volume (in terms of calories or kilojoules) of food and drink. But it may be that some people crave carbohydrate, store fat, burn protein or metabolise alcohol more readily than others, therefore leading to individual specific weight loss effects. To date we’re unable to determine which diet suits which person best, but it’s likely to be a question that will be better answered in the future. Why does a reduction in total food intake help people live longer? For 2-3 decades now it’s been known that all mammals, including humans, tend to live longer if they have less, rather than more access to food; that is, provided they have enough to survive. The general estimate is that a decrease of around 30% of food intake that would be eaten in an ad-lib food environment, can add up to 2-3 years of life. But why? We don’t know, but here are some thoughts: Parts of the genome known to be associated with longevity, tend to change with decreased food intake. It’s also possible that the more food to which we are exposed, the higher the likelihood of oxidative stress from free radicals that form from oxygen broken down in food. For an estimated 15,000 free radical ‘hits’ a day in the average person, a decrease of even 1/3 of this, would help decrease the ‘rusting’ that comes with old age. But in truth, we don’t know. The next scam: Indigenous foods for weight loss If native foods are good for you, can they help you lose weight? Jojoba (Simmondsia chinensis) In their desire to keep turning over a buck, entrepreneurs are always on the look-out for new products to flog. It’s even better if these have some semblance of health or sustainability attached to them so they can be flogged in an environmentally friendly way. It’s no surprise therefore to see that one of the latest trends in medicine ie. the use of native plants for health, is about to be taken up in weight control – pushing native plant products used by Indigenous people, for healthy weight loss. But step back with the Professor for a moment to examine the logic behind this. Native plants and health There’s little doubt that native plants have medicinal properties: Indigenous people have used them as such for thousands of years, no doubt with enormous success. Pharmacologists have tapped the rich source of nutriceuticals in such products, and used them, either in natural or synthetic form, to create efficient medications. It’s also probably not unexpected that Indigenous people and powerful, healthy plant products have evolved together. It could even help to explain the ability of humans to evolve to the level they have. But why would such plants be needed to help native peoples lose weight? They never had a weight problem. The problem throughout evolution has generally been to gain weight in the good periods and keep it on in the bad periods. It makes little sense to have a plant that makes one lose weight. Hunger reduction There is a case perhaps for suggesting a temporary ability to reduce hunger. This would help hunters who have to go long periods stalking prey without food to not get desperate and fire an arrow in haste, where it might miss its mark. Indeed, the Jojoba plant of the southern African desert was supposed to have just such an effect on the Hottentot people of the African desert. With that in mind, it was picked up by a major multinational drug company to sell as a weight loss treatment. But the effect was transitory. While Jojoba extract worked on Hottentots, and possibly even for short periods in westerners, it had no long-term impact on weight loss in clinical trials. Mother Nature appears efficient in her ability to develop useful synergies between plants and animals. But evolution has determined that the main advantage of this is to survive. Weight loss in contrast to weight gain, is not a survival technique, at least not in lean hunter-gathers. So don’t wait up for the natural weight loss plant. THE PROFESSOR’S POINTS Why are some natural foods healthy, but their ‘de-natured’ or processed equivalents unhealthy? Again, this is in the realms of speculation, but recent research suggests that markers of inflammation are increased in the blood immediately after eating a de-natured’ food (eg. processed white rice), compared with its natural equivalent (eg. unprocessed brown rice). thus de-naturing the original, the body could see this as a foreign invader and react accordingly. It’s early days, but this process has now been considered as an underlying cause of modern chronic diseases. Is it more difficult to keep weight off after losing if obesity has been long term? A typical response to weight loss in people who have been big for some time, is a regain over time. Indeed, this seems to require much less of a change in energy to put on weight than for someone of the same weight who has never been overweight before. A simple answer to why this may be to, the more hungry you seem to get. so is ‘fat memory’. Like muscle memory, There are chemicals in the body that where body builders who have are associated with this. But these tend stopped weight lifting, find it easier to to explain how it happens, rather than regain the muscle lost than someone why. It’s likely that there is an answer who never was a body builder, the hidden somewhere deep down in the brain seems to want to return to a brain, but at the moment we don’t level of fatness it once had, possibly know what it is. to increase the chances of survival in a famine. We know these changes are manifest through physiological changes, such as changes in metabolic rate, hunger levels etc., but we don’t know why. Is there a switch in the brain that flicks over with weight gain and flicks off more quickly with weight loss? Inflammation is generally a response That question remains to be answered. to a foreign body or injury, like a Why are some people perpetually more hungry than others? bacteria or virus. But a new form of inflammation discovered in the last decade, suggests that it can also occur, albeit at a lower level, to different Again, the simple answer is probably types of foods with which the body genes. But it’s not the whole answer. hasn’t evolved. Humans have eaten We know that hunger levels can also brown rice for thousands of years, change throughout life – and these as an example, and hence, the body can be influenced by experiences, such sees this as a ‘friend’. When the germ is as availability of food. taken off brown rice to make it white, Ironically, the more you have access Why do some people FAT get fat just looking at FACTS food, and others stay lean and trim while eating like a horse? To paraphrase Bob Dylan: The answer, my friend is written in the genes. But genes have to have an effect on either ‘energy in’, or ‘energy out’, if they are to change body fat storage. The effect is through a range of feedback mechanisms like metabolic rate, hunger level, energy use of exercise etc. There is not one gene, but possibly hundreds that have these individual effects. Some people have some. Some have them all. Hence, it’s very easy for those with a host of fat genes to put on weight, particularly in an obesogenic environment. If you’re lucky enough not to have any, you can probably eat til your heart is content, without weight gain. But just pray there’s no famine. Because If that happens, you’ll be one of the first casualties of starvation.
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