NICARAGUA Figure 1. Malaria by Annual Parasite Index (API) at municipality level (ADM2), Nicaragua, 2014 Malaria is endemic in the Moskitia area along the Atlantic coast in the northwestern part of the country that shares a border with Honduras (Figure 1). In 2014, Nicaragua had reported 1,163 cases of malaria and no deaths (Figure 2). The department of North Caribbean Coast Autonomous Region (RACCN) has the highest amount of cases and is home to some of the country’s most affected municipalities such as Waspan (26.2% of all 2014 malaria cases), Rosita (22.6%), Puerto Cabezas (15.4%), and Prinzapolka (9.8%) (Figure 3). However, malaria is also present in other parts of the country including along the northern Pacific coast in the department of Chinandega where sugar-cane plantations are areas of mosquito proliferation. The department of South Caribbean Coast Autonomous Region (RACCS) has had an increase in the past few years. Cases in Desembocadura de la Cruz de Rio Grande Honduras Nicaragua API per 1,000 people No cases ≤ 0.1 0.11 - 1 1.01 - 5 Figure 2. Number of cases and deaths due to malaria in Nicaragua, 2000-2014 5.01 - 10 10.01 - 50 25,000 10 20,000 10 6 20,000 2014 2013 2012 2011 2010 2008 2009 2007 2004 2006 0 5,000 P. falciparum & Mixed Deaths ■ P. falciparum &0mixed ■ Confirmed cases ■ Deaths Confirmed Cases 2014 2013 2012 2011 2010 2009 2008 2007 P. falciparum & Mixed Deaths Department 336 the highest398 305 cases in Nicaragua, 2012-2014 RACCN3. ** Municipalities with Figure number of malaria Waspan 115 RACCN ** Puerto Cabezas P rinzapol ka Bonanza Municipality RACCN ** 238 Department 253 Waspan RACCN ** Rosita RACCN ** Puerto Cabezas RACCS‡ 86RACCN ** RACCN 135 ** 32 RACCN ** RACCN ** 2 Wiwili de Jinotega P rinzapol Jinotegaka Bonanza RACCN ** 93 El Viejo C hinandega Desembocadura* 37 RACCS‡ Siuna RACCN** Desembocadura* de Jinotega9 Laguna d e Perlas Wiwili RACCS‡ El Viejo 0 Decrease Siuna Increase Laguna d e Perlas Decrease Increase 171 35 115127 17 686 253 135 78 32 23 2 1 93 C hinandega 200 400 0 37 RACCN** 2012 9 RACCS‡ Jinotega 200 2013 263 179 114 398 336 51 50 171 35 40 32127 17 28 6 15 78 400 0 23 305 238 263 179 114 51 50 40 200 2014 32 400 28 1 15 *Desembocadura de Rio Grande Caribbean Coast Region 0**North200 400 0 Autonomous 200 400 0 ‡South2012 Caribbean Coast Autonomous Region 2013 200 2014 400 *Desembocadura de Rio Grande **North Caribbean Coast Autonomous Region ‡South Caribbean Coast Autonomous Region 86 86 - 84 - 2006 2005 2004 2003 2002 2001 2000 Confirmed Cases Rosita 25 50 ® 100 Kilometers Longitude/Latitude Datum WGS84 Source: PAHO/CHA/VT municipality almost tripled in 2014 from the previous 8 year. Together, RACCN and RACCS account for 90% of all malaria cases in Nicaragua. During 2012-2014, 6 there were 7 municipalities reporting more than 1 case per 1,000 inhabitants in one or more years (stratum 4 (Figure 4). Main factors contributing to malaria in 3) Nicaragua are migration, natural disasters (floods), and 2 drug trafficking. Improved surveillance has also led to the detection of more cases. Approximately 2% of cases 0 were reported imported in 2014. On the contrary, Costa Rica has reported five imported cases from Nicaragua since 2011. Deaths 2 10,000 2005 2001 2000 0 4 15,000 2003 10,000 Deaths 15,000 5,000 Municipality 0 8 25,000 2002 Number of cases Number of cases >50 Costa Rica onon thethe Situation of Malaria in the 2000-2014 (DRAFT V.3) V.3) Situation of Malaria inAmericas, the Americas, 2000-2014 (DRAFT Figure 4. Number of municipalities (ADM2) by strata in Nicaragua, 2012-2014 Figure 5. Malaria cases by age and sex in Nicaragua, 2014 90 Stratum 2 56 Stratum 2 Stratum 3 Stratum 3 7 7 0 Age groups 50+ 50+ 45-49 years 20 80 45-49 years Female 40-44 years Male 40-44 years 100 35-39 years Female Male 80 100 35-39 years 30-34 years Number of municipalities on the Situation Malaria in the Americas, 2000-2014 (DRAFT V.3) 30-34 years *Stratum 1: No autochthonous malaria case inof2012-2014; 25-29 years Stratum1:2:No <1 autochthonous case per 1,000 inhabitants in 2012-2014; *Stratum malaria case in 2012-2014; 25-29 years 20-24 years Stratum 3:2: >1<1 case perper 1,000 inhabitants in 2012-2014. Stratum case 1,000 in 2012-2014; on inhabitants the Situation of Malaria in the Americas, 2000-2014 (DRAFT V.3) years years Stratum 3: >1 case per 1,000 inhabitants in 2012-2014.15-19 20-24 Age groups 90 50+ Stratum 1 MenStratum were45-49 more affected than women in 2014 56 (Figure 5), Female 2 years 6 Age groups 56 40 60 20 (DRAFT 40of municipalities 60 Number 2000-2014 V.3) 0 Situation of Malaria in the Americas, 90 90 10-14 15-19 years years Age groups 5-9 10-14 years years 50+ Under 5 years 5-9 years Age groups 90 45-49 Unknown Under 5 40-44 years 50+ Unknown 100 45-49 years 35-39 years 100 100 100 75 25 50 50 0 75 25 25 75 50 75 50 0 25 25 50 25 0 25 0 25 50 50 75 75 75 100 100 2014 2013 2012 2010 2011 2009 2008 2007 2006 2005 2004 2002 2003 2014 2012 2013 2011 2010 2009 2008 * First line treatment data is unavailable for 2001-2004. 2014 2013 2013 2014 2012 2011 2012 Others 2014 2013 2012 2011 2009 2007 Others 2008 2006 2005 2004 2003 0.0M 3.0M 4.0M 2014 2010 2011 2013 2009 2010 2009 2008 2007 2010 2011 2009 2006 2004 2005 2008 2003 2007 2002 2006 2005 2000 2001 0.0M * First line treatment data is unavailable for 2001-2004. 0.0M 2.0M 2012 0.5M 2010 1.0M 3.0M 2008 0.5M 1.0M 2.0M 4.0M 0.0M $ (in millions) 2014 2013 2012 2011 2009 3.0M Confirmed Cases 1.0M 1.5M 3.0M 2.0M *Funding information is not available for 2001-2005. People protected by ITNs People protected by IRS Government Global Fund USAID People protected by ITNs 1.0M 2.0M 2010 2008 2007 2006 1.0M 2005 0.0M 2004 1.0M 1.0M Confirmed Cases First-line treatments 1.5Mtreatment 2.0M data is unavailable for 2001-2004. * First line 4.0M *Funding 1.0M information is not available for 2001-2005. 4.0M Government Global Fund USAID People protected by IRS 1.5M 2.5M 2002 SPR (%) Cases per 100,000 people 100 75 100 0% SPR (%) Blood Slides Examined 1.5M 2.0M 0.0M 2012 2011 2013 2012 2014 2013 2013 2014 2014 2003 2002 2006 Blood Slides Examined RDTs Examined 2001 3.0M 0.5M 2009 2007 2009 2008 2010 2010 2009 2011 2011 2010 2012 0 RDTs Examined 4.0M 0.0M 1.0M 2003 2005 2004 2006 2007 2005 2007 2008 2006 2008 2000 2002 2004 2001 2003 2005 2002 2004 2001 2000 * 1.5M First line treatment 200,000data is unavailable for 2001-2004. 2% People protected by 0 0%IRS 0.5M People protected by ITNs First-line treatments 2004 4% 0.0M 2.0M 2002 2013 2012 2010 2011 2009 2008 2007 2006 2005 2004 2003 People protected by ITNs 2% 0.5M 2003 2014 2013 2011 2009 2010 2008 2007 2006 2004 2005 2012 SPR (%) People protected by IRS 5-9 10-14 15-19 20-24 25-29 30-34 35-39 40-44 45-49 50+ yrs yrs yrs yrs yrs yrs yrs yrs yrs yrs Figure 8. Number of malaria cases and those treated with first-line treatment in Nicaragua, 2000-2014 * First line treatment 2.5M data is unavailable for 2001-2004. 6% 4% Unde r5 2001 2014 2012 2013 2011 2009 2010 2008 2007 2006 2004 2005 2003 2002 6% SPR (%) Blood Slides Examined 2002 2001 200,000 2003 2002 2001 People examined 2000 2000 1.0M 2% Confirmed Cases 0% 2003 rotected by ITNs 400,000 0.5M 1.5M RDTs Examined 0.0M 400,000 2002 rotected by IRS Blood Slides Examined 600,000 2001 PR (%) 0 1.0M 2000 0% 600,000 1.5M RDTs Examined 2000 n millions) 2% Slide Positivity Rate (SPR) 4% 2001 2.0M 200,000 6% 2000 Figure 7. Blood slides examined, RDTs examined, 2.5M First-line and SPR in Nicaragua, 2000-2014 0 0% treatments 0.0M 1.0M Number of people (in millions) 2000 2000 2001 2001 2002 2002 2003 2003 2004 2004 2005 2005 2006 2006 2007 2007 2% 4% 2001 200,000 400,000 Cases per 100,000 people Unde 5-9 10-14 15-19 20-24 25-29 30-34 35-39 40-44 45-49 50+ 4% 400,000 r 5 600,000 yrs yrs yrs yrs yrs yrs yrs yrs 6%yrs yrs 2000 Slide Positivity Rate (SPR) 0 2001 9 8 6% 2000 11 10 600,000 5 8 Confirmed cases 9 Diagnosis and Treatment 11 0 10 35Microscopy 8 Unde 5-9 10-14 15-19 20-24 25-29 30-34 35-39 40-44 45-49 50+ is the primary method of diagnosis in the 30 5 Female r 530 yrs yrs yrs yrs yrs yrs yrs yrs though RDTsyrswere introduced inyrs2006 for use in 0 country, Male 35 that are difficult to access (Figure 7). Nicaragua’s 30 Female 25places Unde 5-9 10-14 15-19 20-24 25-29 30-34 35-39 40-44 45-49 50+ 30 26 is r5 yrs treatment yrs yrs yrschloroquine yrs yrs and yrs primaquine yrs yrs yrs first-line for Male 20 21 both25P. falciparum and P. vivax infections. An observed 2.5M and primaquine (30 mg/kg/day) 15dosage of chloroquine 26 First-line treatments 13 20 21 2.0M is given over the course of 7 days for treatment of P. vivax 10 11 Confirmed Cases 9 15 10 in Nicaragua as compared to a 15 mg/kg/day dosage 13 8 1.5M 2.5M5 First-line treatments for 14 days that is given in Honduras. The difference in 10 11 9 2.0M0dosage10 may cause confusion along the borderCases for those 8 Confirmed 1.0M 5 5-9 10-14 15-19 20-24 25-29 30-34 35-39 40-44 45-49 50+ Unde with P. vivax infections due to the varying treatment 1.5M r 50 yrs yrs yrs yrs yrs yrs yrs yrs yrs yrs 0.5M schemes. US$ (in millions) 13 10 2014 Slide Positivity Rate (SPR) Slide Positivity Number of people (in millions) US$ (in millions)Rate (SPR) 21 13 10 2000 26 20 5 Number of people (in millions) US$ (in Slide millions) Positivity Rate (SPR) Number of people (in millions) Cases per 100,000 people Female Male 25 People protectedPeople (in millions) People examined protected (in millions) People examined Number of people (in millions) US$ (in millions) cted (in millions) People examined 100 Cases per 100,000 people 75 50 25 0 25 50 30 30 15 75 100 Cases per 100,000 people 35 2014 2013 80 50 40-44 years Stratum 1to7 have incidence rates of 17.7 andMale and were found 14.9 Female Stratum 3 100 years cases per35-39 100,000 people, respectively. Analysis by56age Stratum 2 Male 20 40 30-34 0 years men groups shows incidence60at most 80 Female Stratumthat 3 7 have higher Number of municipalities s malaria case in 2012-2014; Confirmed cases 40-44 years 30-34 years 25-29 6). years ages (Figure Children (10-14) and adolescents (15Male 000 inhabitants in 2012-2014; 0 201: No autochthonous 40 60 case in 2012-2014; 80 100 *Stratum malaria 35-39 years 20-24highest years Confirmed cases 000 inhabitants in 2012-2014. 19) had the incidence of2:malaria. There were an in 2012-2014; 25-29 years Number of1,000 municipalities Stratum <1 case per inhabitants 30-34 years 15-19 20-24 years Stratum >1 case perpregnancies 1,000 inhabitants in 2012-2014. estimated 17years malaria cases per3:100,000 *Stratum 1: No autochthonous malaria case in 2012-2014; 25-29 years 10-14 years 15-19 years 35 in 2012-2014; in 2014, which was similar to the 2: incidence in1,000 nonStratum <1 case per inhabitants 30 years Female 20-24 Priority Groups 5-9 years 10-14 years Stratum 3: >1 case per 1,000 inhabitants in 2012-2014. 30 pregnant women of child-bearing age, implying that Male 35 The Miskito 15-19 years of Nicaragua are disproportionally people Under 5 5-9 years 30 Female pregnant women were not at a higher risk of having 25 30 10-14 Unknown Under 5 years due to poverty, underdevelopment, affected by malaria 26 malaria. Male 5-9 years to healthcare compared to the rest Unknown 20 and limited access 21 25 UnderThe 5 of the country. area they inhabit traverses the 26 Confirmed Figure 6. Malaria incidence by age and cases sex in 15 Unknown which poses a problem for disease 1320 Honduran border, 21 Confirmed cases Nicaragua, 2014 10 11 9 10 15 tracking. 60 alities 100 Stratum 1 Stratum 1 - 85 - 5 US$ (in millions) Number of people (in millions) 1.5M Funding 2.5M 1.0M Governmental 2.0M 2014 2013 2013 2014 2012 2013 *Funding information is not available for 2001-2005. 2014 2013 2012 2011 2010 2008 2009 2007 2006 2004 2005 2003 2002 0.0M 2001 2014 2012 2013 2012 2011 2011 2010 Government Global Fund USAID Others 2014 2008 2012 2011 2010 2009 Others 2008 2007 2006 USAID 2005 2004 2003 2002 2001 2000 Global Fund 2009 2007 2006 2005 2004 2002 0.0M2.0M 0.0M Government 2014 2013 2012 2011 2009 2010 2008 2007 2006 2005 2004 2003 2002 2001 2000 2011 2010 2009 3.0M 1.0M 1.0M *Funding information is not available for 2001-2005. 0.0M 0.5M 2010 2008 2009 2008 2007 2005 2007 2006 2004 2006 2004 2005 2003 2002 2003 2002 2001 2000 2001 2000 2.0M4.0M 2003 People protected by ITNs Figure 10. Funding for malaria control in 2000-2014 3.0M Nicaragua, 2000 People protected by IRS 0.5M 1.0M Confirmed Cases 2001 2014 2012 2013 2011 2009 2010 2008 2007 2006 2004 2005 2002 2003 Blood Slides Examined SPR (%) People protected by IRS 1.5M First-line treatments *4.0M First line treatment data is unavailable for 2001-2004. People protected by ITNs 2000 - 86 - 2001 2000 RDTs Examined 5-9 10-14 15-19 20-24 25-29 30-34 35-39 40-44 45-49 50+ yrs yrs yrs yrs yrs yrs yrs yrs yrs yrs treatments funding for malaria at the First-line national level Confirmed Cases has varied from one year to the other. In 2014, it was 0.5M 1.5M less than that in 2013, but higher than any year during 0.0M 2010-2012. The Global Fund has been the main 1.0M contributor of external resources since 2006 through national grants as well as providing resources through 0.5M * First line treatment data is unavailable for 2001-2004. the EMMIE initiative (Figure 10). Other external funders 0.0M include USAID via the AMI/RAVREDA project and PAHO/ WHO. 0% 1.0M People protected (in millions) People protected (in millions) RDTs Blood Slides Examined SPR (%) Figure 9.Examined People protected by IRS and by ITNs in 0 Nicaragua, 2000-2014 1.5M Slide Positivity Rate (SPR) 2% 2.5M Unde r5 2.0M US$ (in millions) 2014 2013 2011 2012 2009 2010 2007 2008 2006 2004 2005 2003 2002 200,000 2001 2000 People examined People examined Vector Control 4%by Nearly 95,000 people are estimated to be protected 400,000 6% 600,000 IRS in Nicaragua, which has decreased steadily since 2007 (Figure 9). Tests conducted in 2012-2014 found both200,000 An. albimanus and An. pseudopunctipennis to2%be 4% 400,000 susceptible to pyrethroids. More people are estimated to be protected by ITNs that IRS in 2014, with ITNs 0 0% protecting 173,000 people. Slide Positivity Rate (SPR) 6% 600,000 Number of people (in millions) 0
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