case-Based review Obsessive-Compulsive Disorder in Children and Adolescents Case Study and Commentary, Phoebe S. Moore, PhD, Suzanne U. Allard, BA, and Martin E. Franklin, PhD Abstract • Objective: To review the application of cognitive behavioral therapy (CBT) for the treatment of obsessive-compulsive disorder (OCD) in children and adolescents. • Methods: Presentation of treatment model with example dialogue. • Results: Pediatric OCD is a prevalent, distressing, and functionally impairing anxiety disorder. The psychosocial treatment for OCD that has the most empirical support is CBT using an exposure and response prevention technique, in which the child gradually exposes him- or herself to OCD-related anxiety or discomfort and then resists ritualizing. As the child learns experientially that anxiety associated with OCD is tolerable and remits over time, more challenging tasks can be accomplished, leading to improvements in symptom severity. Both the child and family learn about the neurobehavioral basis of OCD and form a team with the CBT clinician to “battle” the disease entity. • Conclusion: Hierarchical use of exposure and re sponse prevention in a supportive environment permits habituation to and eventual mastery of OCD symptoms. P ediatric obsessive-compulsive disorder (OCD) is a prevalent, distressing, and functionally impairing anxiety disorder. By late adolescence, the lifetime prevalence of childhood OCD is estimated to be 2% to 3% [1], while point prevalence estimates are between 0.5% and 1% of the pediatric population [2]. In many to most untreated cases, OCD tends to persist in a waxing and waning course through adolescence and into adulthood, indicating a need for early intervention [3]. With treatment, symptoms can often be reduced to subclinical levels, and relapses are less frequent and less intense. OCD is characterized by 2 main symptoms: obsessions and compulsions. Obsessions are recurrent and persistent thoughts, images, or impulses that are ego-dystonic, intrusive, and, for the most part, acknowledged as senseless. Obsessions are generally accompanied by negative affects, such as fear, www.turner-white.com disgust, doubt, or a feeling of incompleteness and are distressing to the affected individual. Young persons with OCD typically attempt to ignore, suppress, or neutralize obsessive thoughts and associated feelings by performing compulsions, which are repetitive, purposeful behaviors performed in response to an obsession, often according to certain rules or in a stereotyped fashion. Compulsions, which can be observable repetitive behaviors, such as washing, or covert mental acts, such as counting, exist at least in part because they serve to neutralize or alleviate obsessions and accompanying distress in the short run. Compulsions can relieve the anxiety or sense of discomfort caused by obsessions, and in this case the compulsive behaviors are strengthened through a process of negative reinforcement. Occasionally, compulsions occur in the absence of reportable obsessions and are experienced as a response to an urge or feeling that one simply must do the ritual; the relief that ensues can also be a negative reinforcer. In children and adolescents, it is common for compulsions to include family members (eg, reassurance seeking). In addition, in contrast to most adults with OCD, children (especially young children) may lack insight into the irrational nature of the obsessions and compulsions [4]. OCD can interfere severely with role functioning, causing impairment in school performance, friendships, family relationships, and vocational functioning [5,6]. For example, children and adolescents may drop out of activities they used to enjoy, avoid social contact, experience academic problems as a result of ritualizing, and lose sleep when obsessions are more salient at night. Thus, in addition to the risk of OCD symptoms persisting into adulthood and causing impairment, pediatric OCD can severely divert the course of normal development, leading to long-term deficits across many areas of functioning. There are a variety of effective treatments for children and adolescents with OCD [7]. Pharmacotherapeutic From the Program in Child and Adolescent Anxiety Disorders, Departments of Psychiatry and Psychology, Duke University Medical Center, Durham, NC (Dr. Moore and Ms. Allard); and the Center for the Treatment and Study of Anxiety, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA (Dr. Franklin). Vol. 13, No. 7 July 2006 JCOM 405 OCD in children and adolescents approaches that have garnered empirical support from multicenter randomized controlled trials include clomipramine [8], fluvoxamine [9], sertraline [10], and fluoxetine [11]. However, the typical response to medication treatment is a 30% to 40% reduction in symptoms, which usually results in clinically significant residual impairment [12]. Cognitive behavior therapy (CBT), particularly models including exposure with response prevention, has also been supported in randomized controlled trials for pediatric OCD [7,13,14]. The effect of CBT may be even larger than that of medication, although methodologic differences between pharmacotherapy and psychotherapy trials make direct comparisons challenging [15]. The maximum benefit may come from a combination of the 2 treatments, and experts recommend that children with OCD be started either with CBT alone or with the combination of CBT and medication [7]. The psychosocial treatment for OCD that has the most empirical support is CBT using a specific technique known as exposure and response prevention (EX/RP). The current version of the treatment [7,16] typically involves 14 sessions over 12 weeks. The first 4 sessions focus on psychoeducation and cognitive training, with an emphasis on the externalization of the OCD as a neurobehavioral problem independent of the child’s self. Using this knowledge—that OCD is “not me” but an external force that is vulnerable to the child’s attempts to regain control—a hierarchy of exposure tasks is developed, starting with easy ways to resist compulsions (eg, touching a bathroom wall at home and not washing), and building up to very challenging EX/RP tasks (eg, touching a toilet seat in a public restroom and not washing). The child is encouraged to “poke OCD with a stick” by doing activities that provoke OCD-related anxiety or discomfort and then resist the ritual that OCD demands be performed. EX/RP tasks are completed in session and as homework, and the child charts his or her anxiety/discomfort level over time using a “fear thermometer” ranging from 1 (easy) to 10 (hardest ever). As the child learns that the anxiety associated with OCD is tolerable and remits over time regardless of ritual performance, more and more challenging tasks can be accomplished. The process of habituation that occurs during the exposures facilitates a sense of control for the patient, and also tends to reduce both the frequency and the intensity of the child’s obsessions and urges to ritualize. In many cases (up to one third of children treated with CBT and up to a half of children receiving CBT plus medication), subclinical status can be attained within the 12 weeks. The family context has special importance in the treatment of pediatric OCD. The messages that the affected child receives from parents and siblings have great impact on how the disorder evolves. For example, many parents believe that the child is being defiant or does not want to resist OCD, leading to a patient-blaming stance and a punitive environ406 JCOM July 2006 Vol. 13, No. 7 ment. In contrast, other families respond to OCD with attempts to placate, resulting in entire families accommodating OCD-related patient discomfort with extra cleaning rituals, avoiding “contaminated” areas, or other adaptations. CASE STUDY Initial Presentation Emily, age 15, presents with her parents to the university clinic with the initial complaint of family conflict. In the course of the intake evaluation, it becomes evident that Emily is experiencing intrusive images (obsessions) of herself harming her younger sister, Kayla, age 8. History When these images occur, usually in the context of feeling angry at Kayla over some small issue, Emily becomes upset and locks herself in her room crying. Her parents are inferring from her behavior that Emily harbors “repressed anger” toward Kayla and that she actually has an intention to hurt her, and they respond by taking Kayla out of the house when conflict appears to be brewing. In addition, they are taking extreme measures to “maintain safety” in the home, keeping all sharp objects and “potential weapons” locked in a kitchen cabinet. Emily is deeply distressed by these obsessions and by her parents’ interpretation, as she reports no wish to harm her sister. The parents’ goal at the initial session is to understand why Emily feels so much anger toward her sister. Emily’s goal is to make her parents understand that she does not wish ill toward her sister and to get help “getting the pictures out of [her] head.” A detailed exploration of the nature of the obsessions is indicated, and the clinician interviews the patient alone. • What are the goals of the patient interview? In this interview, it is important to establish the unwanted nature of the violent image. The clinician should rule out the case where the patient is excited by violent images or expresses intention toward acting out the images. In addition, the presence of any psychotic symptoms should be evaluated; while uncommon, it is important to ensure that there is no disturbance of thought process or reality testing. A careful evaluation of how the image interacts with the patient’s anger level is also important in this case, as the intrusions are sometimes triggered by angry affect on the part of the patient. The clinician should carefully disentangle normative, ego-syntonic fantasies that occur in the context of anger (eg, thinking “I’d like to just hit her!” or imagining a minor violent act) from obsessional, ego-dystonic content (eg, intrusive and more elaborated images of extreme or gruesome www.turner-white.com case-Based review violence). The tendency to try to neutralize or get rid of the violent images is a cardinal feature of this subtype of OCD, whereas intentionally elaborating on the image for pleasure or gratification is not consistent with the diagnosis of OCD. The clinician’s stance in this interview is important. The clinician should be matter-of-fact about the patient’s obsessions, conveying the message that the clinician has heard such things before, even in much more frightening variations from other patients—that is, the patient’s experience is “old hat” to the clinician. For example: Clinician: I’ve met a lot of kids like you, who get thoughts they don’t like or want to have. Sometimes the thoughts can be pretty scary. Can you tell me about the thoughts you have about your sister? Emily: It’s hard to talk about. Clinician: I know that it can be hard to talk about it. How ever, I also know that what your brain is coming up with in these moments has nothing to do with what you want or wish. Emily: I really don’t want it! That’s why I go in my room. There’s just something wrong with me, that I think these things! Clinician: What I think is happening here is that you are getting something called an obsession, which is a medical term for a kind of brain hiccup that some kids have. Obsessions are thoughts that you don’t want to have, that have nothing to do with who you are or what you want. I’ve seen kids who get all kinds of scary images—images about hurting their family members or pets, about hurting themselves, or wrecking things. They don’t want to get these thoughts; it’s just that their brain is kind of misfiring and giving them these images. Is that what you are experiencing? Emily: Yes. I have these images of hurting my sister with knives or hitting her with things. Do other kids really get thoughts like that? Clinician: Absolutely. I’ve heard all kinds of things like that from other kids. And you know what? None of them has ever done anything violent like the images that bother them! This element of normalization, combined with some reassurance by the clinician about the low risk of simply having obsessions, can be very helpful for instilling hope and allowing the patient to share important information with the clinician. The clinician makes it clear early with her words and behavior that the patient’s intrusive thoughts, while upsetting, are not meaningful in terms of her motivations, wishes, desires, or personality nor do they make her a risk to her sister. www.turner-white.com Table. Common Symptoms of Obsessive-Compulsive Disorder in Children and Adolescents Common Obsessions Common Compulsions Contamination Harm to self or others Aggressive themes Sexual ideas/urges Scrupulosity/religiosity Symmetry urges Need to tell, ask, confess Washing Repeating Checking Touching Counting Ordering/arranging Hoarding Praying In patients with obsessions and compulsions, it is important to assess for any additional symptoms of OCD (Table). An assessment tool such as the Children’s Yale-Brown Obsessive Compulsive Scale [17] can be useful. Further Workup An assessment of Emily’s OCD reveals that she has some additional symptoms beyond the violent intrusions. She frequently does visual checks to make sure her sister is physically OK and becomes distressed if her sister is hard to locate. She also has some symptoms of doubt, frequently feeling unsure of herself and repeatedly asking her parents for reassurance about whether she is correct (eg, about homework assignments, family rules). Finally, she has some mild contamination symptoms, fearing that she will spread toxins to her family members, and she avoids touching surfaces that may have chemicals on them and washes for 5 to 6 minutes when she does touch something that she thinks may have a toxic residue. The clinician also evaluates for the presence of other anxiety disorders, mood disorders, attentional and behavioral issues, and trauma/violence/abuse history using the Anxiety Disorders Interview Schedule for children and parents [18]. Emily has some distress and sad mood associated with her OCD symptoms but no full-blown mood disorder nor any comorbid anxiety disorders or trauma history. • What are next steps in evaluation and treatment of OCD? Once symptoms of OCD are identified, they should be separated into domains (in this case, harm images, checking rituals, and contamination concerns), and the patient should reflect upon the degree of control she feels over each domain. Children and adolescents often have more control over OCD symptoms than they initially realize. For Vol. 13, No. 7 July 2006 JCOM 407 OCD in children and adolescents example, Emily can often resist checking on Kayla if Emily is engaged in other activities, such as talking on the phone with friends. In other situations, however, it is too hard for Emily to resist. The circumstances that make compulsions easier or harder to resist should be delineated. This information is then used to build the hierarchy, which is essentially a list of exposure and response prevention tasks that the child can complete, in order from easiest to most difficult. Starting with easier tasks (eg, in response to an urge to check, delaying a visual check on her sister for a few moments) and working her way up (eg, fully resisting the urge to check), the patient can practice experiencing obsessions (exposure) and then resisting rituals (response prevention). Most symptom domains require a hierarchical approach in order to keep the patient’s distress at a tolerable level. However, if the child already has experienced nearly complete success in refraining from compulsions in a particular domain, an efficient strategy may be to “start at the top” (ie, fully resist compulsions in that domain). • How can one make a hierarchy for a symptom such as Emily’s violent intrusions? The idea of staying in the room with her sister in the presence of the violent obsessions is a “10” on Emily’s feelings thermometer. The key to making the hierarchy is finding items below this “10” rating. This is a situation where the use of imaginal exposure can be useful. Imaginal exposure involves the use of the patient’s imagination to develop the full obsession in the form of mental imagery. In Emily’s case, imaginal exposure would involve creating, via discussion, a fully developed mental image of her violent obsession about Kayla (eg, “What is OCD telling you will happen if you get the scary thoughts about Kayla and you don’t leave the room?”). While this sounds counterintuitive to many clinicians, exposure to the content of this violent intrusion can promote habituation and thus reduce the urge to ritualize in response to the violent obsessions. In order to be most effective, the clinician must get the important details of the story. In doing so, the clinician can also convey to the patient that the content of her obsessions, no matter how violent or gruesome, is unimportant. The message that the clinician has “heard it all before” can enhance patient comfort level. For example: Clinician: Now, you and your parents have all alluded to upsetting and violent images that OCD some times gives you. Kids with OCD have different kinds of upsetting thoughts; sometimes they are really gruesome, like out of a horror movie. 408 JCOM July 2006 Vol. 13, No. 7 Emily: Clinician: Emily: Clinician: Emily: Clinician: Emily: Clinician: Emily: Clinician: Emily: One thing that is important to know is: what is the scariest thing that OCD is showing you? For some kids, the scary part is the violence—like seeing an image of themselves stabbing a family member, and the details of that, like the blood and the scared reaction of the family member, are the worst. For other kids, the worst part is the consequence of the violent act—like getting sent to prison, going to hell, or having their other family members stop loving them. Which of these is more like what your OCD throws at you? I don’t think it’s about the consequence. It’s just so scary when I think about hurting Kayla. OK, that helps us, because we need to know the scariest part of what OCD is showing you in order to make it boring. Make it boring! How could it ever be boring? Well, imagine with me for a minute the scariest movie you’ve ever seen. What movie was it? I saw “The Ring” about a year ago at a friend’s house. I couldn’t get the image of that girl com ing out of the TV out of my head for weeks! OK, perfect. So the first time you saw that scene, with the girl crawling out of the TV, you were scared. But what do you think would happen if you watched that scene 10 times in a row? I don’t know; I might still be scared. How about if you watched it 50 times, over and over. Do you think it would still be scary? I don’t know. Actually, I think I’d probably get a little bored of it. Exactly. So let’s pin down OCD together, today, and make OCD tell its story. Then we’ll watch the “OCD video” 50 times together, in our imag inations. What do you think will happen then? Maybe the OCD image won’t scare me so much…? The clinician and Emily put together the story for the imaginal exposure carefully, making sure it is well developed with sensory and emotional details (including, for a stabbing image, the spurting blood, Kayla’s fearful facial expression, and Emily’s feelings of anger, fear, and intense feelings of remorse). They practice exposing Emily to the story, told by the clinician, repeatedly. Repeatedly checking on Emily’s fear level using the feelings thermometer shows empirically the rate of habituation. A hierarchical approach can be used for imaginal exposure as well. If Emily felt that the full content of her obsession was too hard to consider, then an imaginary, OCD-like image containing less scary details (maybe an image of hitting her sister or tripping her) can be illustrative. The key components of learning that occur in these therapeutic www.turner-white.com case-Based review exercises are (1) that the thoughts, no matter how scary, eventually can be made boring, and (2) that thinking about the OCD images, even in elaborated detail, does not make the patient take violent action. Eventually, the images will recede in threat level enough to make in vivo (real life) exposures a possibility. Imaginal exposures will make it easier for Emily to try staying in the room with her sister when obsessions are present, and eventually to stay in the room with her sister while holding a potential weapon (eg, dinner knife; baseball bat). Once the highest levels of exposure are tolerated, the OCD is generally under the patient’s control and tends to fade in intensity and frequency. • What if the patient resists doing the EX/RP tasks? For most child and adolescent patients, a challenge awaits the clinician: assisting the patient in finding the motivation to take on the exposure tasks. Resistance or reluctance can occur at any stage in treatment—when conceptualizing OCD, when mapping and planning the hierarchies, when beginning EX/RP tasks, and when the EX/RP tasks reach a level of high challenge. At each step, the clinician can assist the patient in finding the motivation to move forward. First, as alluded to earlier, it is important for the clinician to be completely accepting of the child and his/her symptoms. In addition, EX/RP tasks should start at a level that is not too challenging for the patient but provokes enough anxiety for the patient to understand the habituation process and to begin to believe in the efficacy of EX/RP. Careful evaluation around failures to complete homework and resistance in session can help identify the reason for reluctance. If the task is too hard, brainstorming ways to make it easier and giving the child control over the level of difficulty can be helpful. The clinician can draw an analogy to physical training: the exposures are important because they build “muscle” or strength in the battle against OCD, just like lifting heavy weights or running sprints. Sharing examples of other hypothetical patients with the same concern can also be useful. Finally, the use of contingent rewards can be motivating for children who lack internal motivation or who are feeling discouraged; small rewards (eg, stickers) can be useful, as can token systems that allow the child to earn a larger reward. Effort at attempting exposures, engaging in response prevention, and in using cognitive coping techniques, rather than success, should be rewarded; rewarding only successes can be discouraging, especially for particularly challenging EX/RP tasks. An excellent motivator can be a discussion of what role OCD has played in the child’s life story so far and what the www.turner-white.com child’s story could be like in the future without OCD as a major character. In Emily’s case, the projected story could include a better relationship with her sister, less conflict at home, more self-trust and self-esteem, and a sense of control and autonomy around her own thoughts rather than a feeling of being victimized by them. Sometimes children and adolescents possess low motivation to complete the therapeutic work because they perceive the effort involved in resisting OCD to be more challenging than the effort involved in experiencing obsessions and performing compulsions. This can be common in families that work hard to minimize OCD-related distress, that is, families with high levels of accommodation. In this case, the distress is felt by family members more than by the patient, and thus the family resorts to assisting with OCD rituals. Thus, the therapeutic work must be done in the family format. The withdrawal of family support for symptoms is placed on the hierarchy and approached in that manner. If the patient completely refuses to participate, the parents can withdraw their support gradually. This often will change the contingencies enough to increase patient motivation to control their OCD symptoms. • What if family processes impede treatment progress? The first step in family work for OCD is psychoeducation. Family members need to realize that OCD is a separate phenomenon from the patient, and the clinician can assist the patient and her family members to “form a team” together to resist OCD symptoms. There is often a shift in parent reaction once the biobehavioral model for OCD is presented. It is important to explain to parents that OCD is illogical and meaningless in its content, no matter how morally loaded the content seems to be. Emily’s parents view her violent images as “repressed anger” and view her as a danger to Kayla. It will be important that the clinician help the parents to change their view and instead see the obsessions simply as meaningless “brain hiccups.” Up until now, the family had been taking steps to keep Kayla safe (removing her from the house, removing “weapons” from Emily’s access), and the clinician must insist that the family stop these behaviors and replace them with behaviors that show that they trust Emily and realize that Emily is not a danger to Kayla. Thus, allowing Emily to babysit for Kayla when Emily feels ready will be an important part of the treatment. It shows support for Emily and reinforces the message that, in the absence of any history of violence or any pleasure taken in the thoughts about harming her sister, the obsessions she experiences are meaningless. Finally, parents or other family members are often drawn Vol. 13, No. 7 July 2006 JCOM 409 OCD in children and adolescents into compulsions in a pattern called family accommodation. Parents are often called upon to give reassurance, for example. Other common compulsions that involve family members include bedtime rituals (parents must read a certain story), giving forgiveness, or assisting the patient with checking or cleaning rituals. Again, when family members are embedded in the ritual, withdrawing their involvement needs to be included as part of the hierarchical approach to treatment. Further Course Partway through treatment, Emily has gotten into the habit of asking her mom to reassure her that the violent thoughts are “just OCD.” Her mother is responding with reassurance and hugs for Emily, which is supportive, but it soon becomes apparent that this is a new checking ritual. If reassurance is withheld, Emily becomes distressed. The clinician and Emily discuss the situation, and Emily decides that she is ready for her mother to give just 1 reassurance. Emily will try to resist asking for extra reassurance, but if she does ask, she wants her mother to ignore the question. Over the course of 14 sessions, Emily habituates to the violent intrusions via imaginal exposures and then works on in vivo exposures with response prevention, staying in the room near her sister (resisting the compulsion to leave the room), even in the presence of violent intrusions. She comes to understand that “OCD’s thoughts” (ie, her obsessions) are not meaningful and that she does not need to accommodate her behavior to “OCD’s rules” (compulsions). She also is able to stop her visual checks on her sister, and through a few targeted contamination exposures with prevention of washing rituals, she regains control over her obsessions about toxins and cleaning rituals. At the end of treatment, she reports that she controls 98% of her emotional and behavioral “territory” and that her OCD controls a scant 2%. • How are recurrences prevented? It is common for children and adolescents to still report some level of OCD symptoms, usually occasional obsessions, at the end of treatment. For many children and adolescents, OCD symptoms tend to take a waxing and waning course, and even successfully treated symptoms may recur in the context of stress or developmental changes. Thus, it is important to spend time over the last few sessions of CBT to discuss this possibility and plan for the future. When patients have a firm knowledge of the principles guiding the fight against OCD, they are usually able to intervene early and successfully against recurring obsessive or compulsive symptoms. We often use a “case consultation” model in 410 JCOM July 2006 Vol. 13, No. 7 which we ask the patient, now an expert the EX/RP model, to consult with us on treatment approach for other hypothetical youngsters with different presentations of OCD. Using this case-based approach, the clinician can evaluate how well the patient understands (1) externalizing OCD, (2) differentiating obsessions from compulsions, (3) the tool kit for fighting OCD, (4) the hierarchical approach to exposures, and (5) the principles underlying EX/RP. Any areas of knowledge deficit can be shored up through this mechanism, as noted below: Clinician: I have a patient who feels like his shoes need to be lined up perfectly in his closet; his OCD tells him that they need to be perfect or he’ll be uncomfortable for the rest of the day. What would you recommend for him? Emily: Well, he could try throwing his shoes all over the place and leaving them like that, all messy. Clinician: That would certainly be resisting OCD! How do you think I can convince him to do that? He’s just starting treatment, and he really thinks that OCD might be telling him the truth. Emily: Well, maybe he could do something a little easier? Clinician: What would you recommend? Emily: I guess he could use the feelings thermometer to figure out what might be easier. Maybe if he just moved 1 shoe out of line a little bit? Or maybe he could start a little harder, like 1 pair messed up but the rest lined up. In this way, the clinician draws Emily’s attention to the importance of the hierarchical approach to exposures and thus increases her probability of success in the face of recurring OCD symptoms. SUMMARY Understanding therapeutic principles, first by the clinician and then by the patient, is vital for improvement and maintenance of treatment gains. The first step is careful and thorough assessment, with systematic evaluation of comorbidity and differential diagnosis. Once pediatric OCD is identified, the child and family learn about the neurobehavioral basis of OCD and thus form a team with the CBT clinician to battle the disease entity. Carefully planned, hierarchical use of EX/RP in this supportive environment will then permit habituation to and eventual mastery of OCD symptoms, feelings, and behaviors. Finally, training in relapse prevention and as-needed consult and booster sessions with the CBT clinician can prevent OCD from recurring at anything beyond a mild intensity. Corresponding author: Phoebe S. Moore, PhD, Duke Child and www.turner-white.com case-Based review Family Study Center, 718 Rutherford St., Durham, NC 27705, [email protected]. Financial disclosures: None. 9. Author contributions: conception and design, PSM, MEF; drafting of the article, PSM, MEF; critical revision of the article, SMA, MEF; administrative or technical support, SMA. 10. References 1. Rapoport JL, Inoff-Germain G, Weissman MM, et al. 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J Am Acad Child Adolesc Psychiatry 1998;37:1022–9. Abramowitz JS, Whiteside SP, Deacon BJ. The effectiveness of treatment for pediatric obsessive-compulsive disorder: a meta-analysis. Behav Ther 2005;36:55–63. March JS, Mulle K. OCD in children and adolescents: a cognitive-behavioral treatment manual. New York: Guilford Press; 1998. Scahill L, Riddle MA, McSwiggin-Hardin M, et al. Children’s Yale-Brown Obsessive Compulsive Scale: reliability and validity. J Am Acad Child Adolesc Psychiatry 1997;36:844–52. Silverman WK, Albano AM. Anxiety disorders interview schedule (ADIS-IV) for DSM-IV: child and parent versions. New York: Oxford University Press; 1996. Copyright 2006 by Turner White Communications Inc., Wayne, PA. All rights reserved. www.turner-white.com Vol. 13, No. 7 July 2006 JCOM 411
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