Homo sapiens taste receptor, type 2, member
38 (TAS2R38), mRNA
NCBI Reference Sequence: NM_176817.4
FASTA Graphics
nuccore
1
genbank
Go to:
LOCUS
2012
DEFINITION
ACCESSION
VERSION
KEYWORDS
SOURCE
ORGANISM
REFERENCE
AUTHORS
TITLE
JOURNAL
PUBMED
REMARK
NM_176817
1143 bp
mRNA
linear
PRI 23-SEP-
Homo sapiens taste receptor, type 2, member 38 (TAS2R38), mRNA.
NM_176817
NM_176817.4 GI:261490644
.
Homo sapiens (human)
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
1 (bases 1 to 1143)
Campbell,M.C., Ranciaro,A., Froment,A., Hirbo,J., Omar,S.,
Bodo,J.M., Nyambo,T., Lema,G., Zinshteyn,D., Drayna,D.,
Breslin,P.A. and Tishkoff,S.A.
Evolution of functionally diverse alleles associated with PTC
bitter taste sensitivity in Africa
Mol. Biol. Evol. 29 (4), 1141-1153 (2012)
22130969
GeneRIF: Report striking patterns of variation at TAS2R38,
including a significant excess of novel rare nonsynonymous
polymorphisms that recently arose only in Africa, high
frequencies
of haplotypes in Africa associated with intermediate bitter taste
sensitivity.
REFERENCE
2 (bases 1 to 1143)
AUTHORS
Lipchock,S.V., Reed,D.R. and Mennella,J.A.
TITLE
Relationship between bitter-taste receptor genotype and solid
medication formulation usage among young children: a
retrospective
analysis
JOURNAL
Clin Ther 34 (3), 728-733 (2012)
PUBMED
22440514
REMARK
GeneRIF: Children with >/=1 bitter-sensitive allele (TAS2R38 PP
or
AP genotype) were more likely to have taken medication in solid
formulation than were bitter-insensitive (AA genotype) children.
REFERENCE
3 (bases 1 to 1143)
AUTHORS
Colares-Bento,F.C., Souza,V.C., Toledo,J.O., Moraes,C.F.,
Alho,C.S., Lima,R.M., Cordova,C. and Nobrega,O.T.
TITLE
Implication of the G145C polymorphism (rs713598) of the TAS2r38
gene on food consumption by Brazilian older women
JOURNAL
Arch Gerontol Geriatr 54 (2), E13-E18 (2012)
PUBMED
REMARK
REFERENCE
AUTHORS
TITLE
JOURNAL
PUBMED
REMARK
REFERENCE
AUTHORS
Naylor,C.,
TITLE
natural
JOURNAL
PUBMED
REMARK
variation
REFERENCE
AUTHORS
TITLE
cells
JOURNAL
PUBMED
REFERENCE
AUTHORS
TITLE
JOURNAL
PUBMED
REFERENCE
AUTHORS
TITLE
JOURNAL
PUBMED
REMARK
REFERENCE
AUTHORS
TITLE
JOURNAL
PUBMED
REMARK
REFERENCE
AUTHORS
21763010
GeneRIF: G145C polymorphism (rs713598) related to taste and food
preferences and habits
4 (bases 1 to 1143)
Calo,C., Padiglia,A., Zonza,A., Corrias,L., Contu,P., Tepper,B.J.
and Barbarossa,I.T.
Polymorphisms in TAS2R38 and the taste bud trophic factor, gustin
gene co-operate in modulating PROP taste phenotype
Physiol. Behav. 104 (5), 1065-1071 (2011)
21712049
GeneRIF: The data of this study showed how the combination of the
TAS2R38 and gustin gene genotypes modulate PROP phenotype.
5 (bases 1 to 1143)
Lucock,M., Ng,X., Boyd,L., Skinner,V., Wai,R., Tang,S.,
Yates,Z., Choi,J.H., Roach,P. and Veysey,M.
TAS2R38 bitter taste genetics, dietary vitamin C, and both
and synthetic dietary folic acid predict folate status, a key
micronutrient in the pathoaetiology of adenomatous polyps
Food Funct 2 (8), 457-465 (2011)
21769326
GeneRIF: study examined bitter taste genetics and whether
in the TAS2R38 gene at three polymorphic loci (A49P, V262A and
I296V) could alter dietary and systemic folate levels and dietary
vitamin C intake
6 (bases 1 to 1143)
Zhang,Y., Hoon,M.A., Chandrashekar,J., Mueller,K.L., Cook,B.,
Wu,D., Zuker,C.S. and Ryba,N.J.
Coding of sweet, bitter, and umami tastes: different receptor
sharing similar signaling pathways
Cell 112 (3), 293-301 (2003)
12581520
7 (bases 1 to 1143)
Bufe,B., Hofmann,T., Krautwurst,D., Raguse,J.D. and Meyerhof,W.
The human TAS2R16 receptor mediates bitter taste in response to
beta-glucopyranosides
Nat. Genet. 32 (3), 397-401 (2002)
12379855
8 (bases 1 to 1143)
Montmayeur,J.P. and Matsunami,H.
Receptors for bitter and sweet taste
Curr. Opin. Neurobiol. 12 (4), 366-371 (2002)
12139982
Review article
9 (bases 1 to 1143)
Margolskee,R.F.
Molecular mechanisms of bitter and sweet taste transduction
J. Biol. Chem. 277 (1), 1-4 (2002)
11696554
Review article
10 (bases 1 to 1143)
Anne-Spence,M., Falk,C.T., Neiswanger,K., Field,L.L.,
Marazita,M.L., Allen,F.H. Jr., Siervogel,R.M., Roche,A.F.,
Crandall,B.F. and Sparkes,R.S.
TITLE
JOURNAL
PUBMED
COMMENT
Estimating the recombination frequency for the PTC-Kell linkage
Hum. Genet. 67 (2), 183-186 (1984)
6745938
REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC104933.1.
This sequence is a reference standard in the RefSeqGene project.
On Oct 17, 2009 this sequence version replaced gi:223278414.
Summary: This gene encodes a seven-transmembrane G protein-
coupled
receptor that controls the ability to taste glucosinolates, a
family of bitter-tasting compounds found in plants of the
Brassica
sp. Synthetic compounds phenylthiocarbamide (PTC) and
6-n-propylthiouracil (PROP) have been identified as ligands for
this receptor and have been used to test the genetic diversity of
this gene. Although several allelic forms of this gene have been
identified worldwide, there are two predominant common forms
(taster and non-taster) found outside of Africa. These alleles
differ at three nucleotide positions resulting in amino acid
changes in the protein (A49P, A262V, and V296I) with the amino
acid
combination PAV identifying the taster variant (and AVI
identifying
the non-taster variant). [provided by RefSeq, Oct 2009].
Sequence Note: This RefSeq represents the non-taster AVI allele
which is defined by polymorphic variation at three positions
(A49P,
A262V, and V296I).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the
Gene
record to access additional publications.
REFSEQ_SPAN
PRIMARY_IDENTIFIER PRIMARY_SPAN
1-1143
BC104933.1
1-1143
FEATURES
Location/Qualifiers
source
1..1143
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q34"
gene
1..1143
/gene="TAS2R38"
/gene_synonym="PTC; T2R38; T2R61"
/note="taste receptor, type 2, member 38"
/db_xref="GeneID:5726"
/db_xref="HGNC:9584"
/db_xref="HPRD:09672"
/db_xref="MIM:607751"
exon
1..1143
/gene="TAS2R38"
/gene_synonym="PTC; T2R38; T2R61"
/inference="alignment:Splign"
/number=1
PRIMARY
COMP
STS
misc_feature
CDS
1..1143
/gene="TAS2R38"
/gene_synonym="PTC; T2R38; T2R61"
/db_xref="UniSTS:490162"
70..72
/gene="TAS2R38"
/gene_synonym="PTC; T2R38; T2R61"
/note="upstream in-frame stop codon"
85..1086
/gene="TAS2R38"
/gene_synonym="PTC; T2R38; T2R61"
/note="PTC bitter taste receptor; taste receptor type 2
member 61"
/codon_start=1
/product="taste receptor type 2 member 38"
/protein_id="NP_789787.4"
/db_xref="GI:261490645"
/db_xref="CCDS:CCDS34765.1"
/db_xref="GeneID:5726"
/db_xref="HGNC:9584"
/db_xref="HPRD:09672"
/db_xref="MIM:607751"
/translation="MLTLTRIRTVSYEVRSTFLFISVLEFAVGFLTNAFVFLVNFWDV
VKRQALSNSDCVLLCLSISRLFLHGLLFLSAIQLTHFQKLSEPLNHSYQAIIMLWMIA
NQANLWLAACLSLLYCSKLIRFSHTFLICLASWVSRKISQMLLGIILCSCICTVLCVW
CFFSRPHFTVTTVLFMNNNTRLNWQIKDLNLFYSFLFCYLWSVPPFLLFLVSSGMLTV
SLGRHMRTMKVYTRNSRDPSLEAHIKALKSLVSFFCFFVISSCVAFISVPLLILWRDK
IGVMVCVGIMAACPSGHAAILISGNAKLRRAVMTILLWAQSSLKVRADHKADSRTLC"
misc_feature
136..198
/gene="TAS2R38"
/gene_synonym="PTC; T2R38; T2R61"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P59533.3);
transmembrane region"
misc_feature
142..210
/gene="TAS2R38"
/gene_synonym="PTC; T2R38; T2R61"
/inference="protein motif:TMHMM:2.0"
/note="Region: transmembrane helix"
misc_feature
247..315
/gene="TAS2R38"
/gene_synonym="PTC; T2R38; T2R61"
/inference="protein motif:TMHMM:2.0"
/note="Region: transmembrane helix"
misc_feature
250..312
/gene="TAS2R38"
/gene_synonym="PTC; T2R38; T2R61"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P59533.3);
misc_feature
misc_feature
misc_feature
misc_feature
misc_feature
misc_feature
misc_feature
misc_feature
misc_feature
misc_feature
transmembrane region"
367..435
/gene="TAS2R38"
/gene_synonym="PTC; T2R38; T2R61"
/inference="protein motif:TMHMM:2.0"
/note="Region: transmembrane helix"
367..429
/gene="TAS2R38"
/gene_synonym="PTC; T2R38; T2R61"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P59533.3);
transmembrane region"
511..573
/gene="TAS2R38"
/gene_synonym="PTC; T2R38; T2R61"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P59533.3);
transmembrane region"
514..582
/gene="TAS2R38"
/gene_synonym="PTC; T2R38; T2R61"
/inference="protein motif:TMHMM:2.0"
/note="Region: transmembrane helix"
655..717
/gene="TAS2R38"
/gene_synonym="PTC; T2R38; T2R61"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P59533.3);
transmembrane region"
679..747
/gene="TAS2R38"
/gene_synonym="PTC; T2R38; T2R61"
/inference="protein motif:TMHMM:2.0"
/note="Region: transmembrane helix"
832..900
/gene="TAS2R38"
/gene_synonym="PTC; T2R38; T2R61"
/inference="protein motif:TMHMM:2.0"
/note="Region: transmembrane helix"
838..900
/gene="TAS2R38"
/gene_synonym="PTC; T2R38; T2R61"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P59533.3);
transmembrane region"
913..981
/gene="TAS2R38"
/gene_synonym="PTC; T2R38; T2R61"
/inference="protein motif:TMHMM:2.0"
/note="Region: transmembrane helix"
913..975
/gene="TAS2R38"
/gene_synonym="PTC; T2R38; T2R61"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P59533.3);
transmembrane region"
192..464
/gene="TAS2R38"
/gene_synonym="PTC; T2R38; T2R61"
/standard_name="G63092"
/db_xref="UniSTS:140067"
STS
ORIGIN
//
1
61
121
181
cctttctgca
atagccaatt
gaagtcagga
aatgccttcg
ccttcg
ctgggtggca
agagaagtga
gtacatttct
ttttcttggt
ttttcttggt
accaggtctt
catcatgttg
gttcatttca
gaatttttgg
gaatttttgg
tagattagcc
actctaactc
gtcctggagt
gatgtagtga
gatgtagtga
aactagagaa gagaagtaga
gcatccgcac tgtgtcctat
ttgcagtggg gtttctgacc
agaggcaggc actgagcaac
agaggcgg Primer Forward
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
agtgattgtg
ctgagtgcta
caagccatca
ctcagcctgc
gcaagctggg
atctgcactg
gtgctattca
tattcctttc
tctgggatgc
aactctcgtg
ttctgcttct
tggcgcgaca
catgcagcca
ctctgggctc
tgctgagaat
gcc
tgctgctgtg
tccagcttac
tcatgctatg
tttactgctc
tctccaggaa
tcctctgtgt
tgaataacaa
tcttctgcta
tgactgtctc
accccagcct
ttgtgatatc
aaataggggt
tcctgatctc
agagcagcct
ggacatgaaa
tctcagcatc
ccacttccag
gatgattgca
caagctcatc
gatctcccag
ttggtgcttt
tacaaggctc
tctgtggtct
cctgggaagg
ggaggcccac
atcctgtgtt
gatggtttgt
aggcaatgcc
gaaggtaaga
tgagctcttc
agccggcttt
aagttgagtg
aaccaagcca
cgtttctctc
atgctcctgg
tttagcagac
aactggcaga
gtgcctcctt
cacatgagga
attaaagccc
gccttcatct
gttgggataa
aagttgagga
gccgaccaca
attaatacgc
tcctgcatgg
aaccactgaa
acctctggct
acaccttcct
gtattattct
ctcacttcac
ttaaagatct
tcctattgtt
caatgaaggt
tcaagtctct
ctgtgcccct
tggcagcttg
gagctgtgat
aggcagattc
ctgtgagtct
actgctgttc
ccacagctac
tgctgcctgc
gatctgcttg
ttgctcctgc
agtcacaact
caatttattt
tctggtttct
ctataccaga
tgtctccttt
actgattctg
tccctctggg
gaccattctg
ccggacactg
tcataaatat
Homo sapiens taste receptor, type 2, member 38 (TAS2R38), mRNA
NCBI Reference Sequence: NM_176817.4
nuccore
LOCUS
DEFINITION
ACCESSION
VERSION
FEATURES
source
gene
exon
CDS
1
genbank
NM_176817
1143 bp
mRNA
linear
PRI 23-SEP-2012
Homo sapiens taste receptor, type 2, member 38 (TAS2R38), mRNA.
NM_176817
NM_176817.4 GI:261490644
Location/Qualifiers
1..1143
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q34"
1..1143
/gene="TAS2R38"
/gene_synonym="PTC; T2R38; T2R61"
/note="taste receptor, type 2, member 38"
1..1143
/gene="TAS2R38"
/gene_synonym="PTC; T2R38; T2R61"
/inference="alignment:Splign"
/number=1
85..1086
/gene="TAS2R38"
/gene_synonym="PTC; T2R38; T2R61"
/note="PTC bitter taste receptor; taste receptor type 2
member 61"
/codon_start=1
/product="taste receptor type 2 member 38"
/protein_id="NP_789787.4"
/db_xref="GI:261490645"
/db_xref="CCDS:CCDS34765.1"
/db_xref="GeneID:5726"
/db_xref="HGNC:9584"
/db_xref="HPRD:09672"
/db_xref="MIM:607751"
/translation="MLTLTRIRTVSYEVRSTFLFISVLEFAVGFLTNAFVFLVNFWDV
VKRQALSNSDCVLLCLSISRLFLHGLLFLSAIQLTHFQKLSEPLNHSYQAIIMLWMIA
NQANLWLAACLSLLYCSKLIRFSHTFLICLASWVSRKISQMLLGIILCSCICTVLCVW
CFFSRPHFTVTTVLFMNNNTRLNWQIKDLNLFYSFLFCYLWSVPPFLLFLVSSGMLTV
SLGRHMRTMKVYTRNSRDPSLEAHIKALKSLVSFFCFFVISSCVAFISVPLLILWRDK
IGVMVCVGIMAACPSGHAAILISGNAKLRRAVMTILLWAQSSLKVRADHKADSRTLC"
ORIGIN
//
1
61
121
181
cctttctgca
atagccaatt
gaagtcagga
aatgccttcg
ccttcg
ctgggtggca
agagaagtga
gtacatttct
ttttcttggt
ttttcttggt
accaggtctt
catcatgttg
gttcatttca
gaatttttgg
gaatttttgg
tagattagcc
actctaactc
gtcctggagt
gatgtagtga
gatgtagtga
aactagagaa gagaagtaga
gcatccgcac tgtgtcctat
ttgcagtggg gtttctgacc
agaggcaggc actgagcaac
agaggcgg Primer Forward
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
agtgattgtg
ctgagtgcta
caagccatca
ctcagcctgc
gcaagctggg
atctgcactg
gtgctattca
tattcctttc
tctgggatgc
aactctcgtg
ttctgcttct
tggcgcgaca
catgcagcca
ctctgggctc
tgctgagaat
gcc
tgctgctgtg
tccagcttac
tcatgctatg
tttactgctc
tctccaggaa
tcctctgtgt
tgaataacaa
tcttctgcta
tgactgtctc
accccagcct
ttgtgatatc
aaataggggt
tcctgatctc
agagcagcct
ggacatgaaa
tctcagcatc
ccacttccag
gatgattgca
caagctcatc
gatctcccag
ttggtgcttt
tacaaggctc
tctgtggtct
cctgggaagg
ggaggcccac
atcctgtgtt
gatggtttgt
aggcaatgcc
gaaggtaaga
tgagctcttc
agccggcttt
aagttgagtg
aaccaagcca
cgtttctctc
atgctcctgg
tttagcagac
aactggcaga
gtgcctcctt
cacatgagga
attaaagccc
gccttcatct
gttgggataa
aagttgagga
gccgaccaca
attaatacgc
tcctgcatgg
aaccactgaa
acctctggct
acaccttcct
gtattattct
ctcacttcac
ttaaagatct
tcctattgtt
caatgaaggt
tcaagtctct
ctgtgcccct
tggcagcttg
gagctgtgat
aggcagattc
ctgtgagtct
actgctgttc
ccacagctac
tgctgcctgc
gatctgcttg
ttgctcctgc
agtcacaact
caatttattt
tctggtttct
ctataccaga
tgtctccttt
actgattctg
tccctctggg
gaccattctg
ccggacactg
tcataaatat