SUPERCEDES: n/a
EHS SOP #: 004
EFFECTIVE DATE: November 2013
VERSION NO.: 1.0
LAST REVISED: November 12, 2013
PREPARED BY: Michael Long
Standard Operating Procedure For Formaldehyde Solution Use in Small Animal Perfusion PURPOSE:
Formaldehyde is a colorless, highly toxic, and flammable gas at room temperature. It is a strong
smelling chemical which is commonly used in research and medical laboratories as an aqueous
solution. This document establishes procedures for the safe handling and use of formaldehyde,
formalin, and paraformaldehyde solutions used in perfusions. Formalin is a 40% formaldehyde
solution while paraformaldehyde is a polymerized form of formaldehyde that depolymerises
when heated. A 4% formaldehyde solution is typically used in animal perfusion. Note that 10%
neutral buffered formalin is approximately 4% formaldehyde.
HEALTH EFFECTS:
Formaldehyde can act as a sensitizing agent and is a known human carcinogen that is linked to
nasal cancer and lung cancer. Acute exposure is highly irritating to the respiratory system and
can cause headaches and eye and throat irritation at very low concentrations.
Signs of acute exposure: Nasal, throat, and pulmonary irritation.
Signs of chronic exposure: Headaches, rhinitis, drowsiness, respiratory impairment, kidney
injury, pulmonary sensitization, and tissue damage. May also cause neuropsychological effects
such as sleep disorders, irritability, altered sense of balance, memory deficits, loss of
concentration, and mood alterations.
REGULATORY LIMITS: The OSHA Formaldehyde standard (29CFR 1910.148) protects
workers exposed to formaldehyde and apply to all occupational exposures to formaldehyde gas,
its solutions, and materials that release formaldehyde.
The permissible exposure limit (PEL) for formaldehyde is 0.75 parts per million (ppm) of
air as an 8 hour time weighted average (TWA). The short term exposure limit (STEL) is 2ppm
maximum exposure over a 15 minute period. OSHA also defines an action level of 0.5ppm
when calculated as an 8-hour TWA which requires increased monitoring and initiation of worker
medical surveillance.
Air Monitoring:
 Area monitoring can be requested to assess potential exposures in the general laboratory
work area. The monitoring is performed using a direct read instrument to give
concentrations in room during perfusions.
 Personal monitoring can be requested to determine potential exposures for individual
employees who work with formaldehyde. The monitoring is performed using a passive
dosimeter that the employee wears in their breathing zone to quantify potential exposure.
 Air monitoring can be requested by contacting Environment, Health & Safety (EHS) at
919-962-5507.
REQUIREMENTS:
Based on the risk associated with the use of formaldehyde solutions, the safety procedures
outlined below are required by all research staff when working with formaldehyde.
Administrative Controls:
 IACUC protocols that include formaldehyde should reference this SOP to verify that the
standard operating procedures are being followed.
 Anyone who uses formaldehyde solutions in perfusions is required to review this SOP
and the attached Safety Data Sheet (SDS) prior to work.
 Storage should take place in a cool, ventilated area, with a tightly closed container.
 An eye wash should be available in the room with a safety shower accessible nearby.
 Employees who use, or may be exposed to, formaldehyde solutions are required to have
formaldehyde training.
Engineering Controls:
 Formaldehyde solutions used in perfusions should be used in a chemical fume hood,
ducted biological safety cabinet, or downdraft table to achieve formaldehyde levels less
than the TWA or STEL.
Personal Protective Equipment (PPE):
 Nitrile gloves, a lab coat, and safety glasses.
 When in rodent barrier facilities, PPE use must be consistent with the facility policy.
Waste Disposal:
 Unused solutions of formaldehyde will be disposed of as a hazardous material through
EHS (HazMat Pickup login)
 Do not discard perfusion waste down the sink.
Accidents or Injuries:
2


If formaldehyde is splashed on an individual or in eyes, flush for 15 minutes with copious
quantities of water and contact the University Employee Occupational Health Clinic
(919-966-9119).
Spill procedures:
o Do not attempt to clean-up if you feel unsure of your ability to do so or if you
perceive the risk to be greater than normal laboratory operations.
o If a small spill occurs rapidly absorb any liquid with absorbent pads or paper
towels and place in chemical fume hood for safe evaporation.
o If a large spill occurs notify others in the area and evacuate room immediately.
Contact EHS (919-962-5507) during working hours and 911 if after hours.
3
SIGMA-ALDRICH
sigma-aldrich.com
Material Safety Data Sheet
Version 4.9
Revision Date 04/26/2012
Print Date 12/06/2013
1. PRODUCT AND COMPANY IDENTIFICATION
Product name
:
Paraformaldehyde
Product Number
Brand
:
:
P6148
Sigma-Aldrich
Supplier
:
Telephone
Fax
Emergency Phone # (For
both supplier and
manufacturer)
Preparation Information
:
:
:
Sigma-Aldrich
3050 Spruce Street
SAINT LOUIS MO 63103
USA
+1 800-325-5832
+1 800-325-5052
(314) 776-6555
:
Sigma-Aldrich Corporation
Product Safety - Americas Region
1-800-521-8956
2. HAZARDS IDENTIFICATION
Emergency Overview
OSHA Hazards
Flammable solid, Target Organ Effect, Toxic by inhalation., Harmful by ingestion., Skin sensitiser, Irritant
Flammable solid, Target Organ Effect, Toxic by inhalation., Harmful by ingestion., Skin sensitiser, Irritant, Carcinogen
Target Organs
Eyes, Kidney, Liver, HeartEyes, Kidney, Liver, Heart
GHS Classification
Flammable solids (Category 2)
Acute toxicity, Oral (Category 4)
Acute toxicity, Inhalation (Category 4)
Skin irritation (Category 2)
Serious eye damage (Category 1)
Skin sensitization (Category 1)
Carcinogenicity (Category 2)
Specific target organ toxicity - single exposure (Category 3)
Acute aquatic toxicity (Category 3)
GHS Label elements, including precautionary statements
Pictogram
Signal word
Hazard statement(s)
H228
H302 + H332
H315
H317
H318
H335
Sigma-Aldrich - P6148
Danger
Flammable solid.
Harmful if swallowed or if inhaled
Causes skin irritation.
May cause an allergic skin reaction.
Causes serious eye damage.
May cause respiratory irritation.
Page 1 of 8
H351
H402
Precautionary statement(s)
P210
P261
P280
P305 + P351 + P338
Suspected of causing cancer.
Harmful to aquatic life.
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
Wear protective gloves/ eye protection/ face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing.
HMIS Classification
Health hazard:
Chronic Health Hazard:
Flammability:
Physical hazards:
2
*
2
2
NFPA Rating
Health hazard:
Fire:
Reactivity Hazard:
2
2
2
Potential Health Effects
Inhalation
Skin
Eyes
Ingestion
Toxic if inhaled. Causes respiratory tract irritation.
Harmful if absorbed through skin. Causes skin irritation.
Causes eye irritation.
Harmful if swallowed.
3. COMPOSITION/INFORMATION ON INGREDIENTS
Synonyms
:
Polyoxymethylene
Formula
Molecular Weight
:
:
HO(CH2O)nH
30.03 g/mol
Component
Paraformaldehyde
CAS-No.
Concentration
30525-89-4
-
4. FIRST AID MEASURES
General advice
Move out of dangerous area.Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a
physician.
5. FIREFIGHTING MEASURES
Conditions of flammability
Flammable in the presence of a source of ignition, through friction or retained heat. Keep away from heat/sparks/open
flame/hot surface. No smoking.
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Sigma-Aldrich - P6148
Page 2 of 8
Special protective equipment for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Hazardous combustion products
Hazardous decomposition products formed under fire conditions. - Carbon oxides
Further information
Use water spray to cool unopened containers.
6. ACCIDENTAL RELEASE MEASURES
Personal precautions
Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate
ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Avoid breathing dust.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment
must be avoided.
Methods and materials for containment and cleaning up
Sweep up and shovel. Contain spillage, and then collect with an electrically protected vacuum cleaner or by wetbrushing and place in container for disposal according to local regulations (see section 13). Keep in suitable, closed
containers for disposal. Contain spillage, pick up with an electrically protected vacuum cleaner or by wet-brushing and
transfer to a container for disposal according to local regulations (see section 13).
7. HANDLING AND STORAGE
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed. Keep away from sources of ignition - No
smoking. Take measures to prevent the build up of electrostatic charge.
Conditions for safe storage
Keep container tightly closed in a dry and well-ventilated place.
Recommended storage temperature: 2 - 8 °C
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Contains no substances with occupational exposure limit values.
Personal protective equipment
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100
(US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole
means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved
under appropriate government standards such as NIOSH (US) or CEN (EU).
Hand protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching
glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in
accordance with applicable laws and good laboratory practices. Wash and dry hands.
Immersion protection
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: > 480 min
Material tested:Dermatril® (Aldrich Z677272, Size M)
Splash protection
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: > 30 min
Material tested:Dermatril® (Aldrich Z677272, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 873000, e-mail [email protected], test method:
EN374
Sigma-Aldrich - P6148
Page 3 of 8
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the
supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an Industrial
Hygienist familiar with the specific situation of anticipated use by our customers. It should not be construed as
offering an approval for any specific use scenario.
Eye protection
Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate
government standards such as NIOSH (US) or EN 166(EU).
Skin and body protection
Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type of protective
equipment must be selected according to the concentration and amount of the dangerous substance at the specific
workplace.
Hygiene measures
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of
workday.
9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance
Form
crystalline
Colour
no data available
Safety data
pH
4.0 - 5.5
Melting
point/freezing point
Melting point/range: 120 - 170 °C (248 - 338 °F) - lit.
Boiling point
no data available
Flash point
70 °C (158 °F) - closed cup
Flammability (solid,
gas)
The substance or mixture is a flammable solid with the category 2.
Ignition temperature
370 °C (698 °F)
Autoignition
temperature
no data available
Lower explosion limit
no data available
Upper explosion limit
no data available
Vapour pressure
no data available
Density
0.88 g/cm3 at 25 °C (77 °F)
Water solubility
insoluble
Partition coefficient:
n-octanol/water
no data available
Relative vapour
density
no data available
Odour
pungent
Odour Threshold
no data available
Evaporation rate
no data available
10. STABILITY AND REACTIVITY
Chemical stability
Stable under recommended storage conditions.
Sigma-Aldrich - P6148
Page 4 of 8
Possibility of hazardous reactions
no data available
Conditions to avoid
Exposure to moisture.
Heat, flames and sparks. Extremes of temperature and direct sunlight.
Materials to avoid
Brass, Steel (all types and surface treatments), Copper, Acid anhydrides, Strong oxidizing agents, Strong reducing
agents
Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides
Other decomposition products - no data available
11. TOXICOLOGICAL INFORMATION
Acute toxicity
Oral LD50
LD50 Oral - rat - 592 mg/kg
Inhalation LC50
LC50 Inhalation - rat - 4 h - 1,070 mg/m3
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and Taste):Eye:Lacrimation. Lungs, Thorax, or
Respiration:Dyspnea.
Dermal LD50
LDLO Dermal - rat - 10,000 mg/kg
Other information on acute toxicity
no data available
Skin corrosion/irritation
Serious eye damage/eye irritation
Eyes - rabbit - Severe eye irritation
Respiratory or skin sensitization
May cause allergic skin reaction.
Germ cell mutagenicity
no data available
Carcinogenicity
Formaldehyde, the decomposition product of paraformaldehyde, has been listed as a carcinogen by NTP and IARC.
Limited evidence of carcinogenicity in animal studies
IARC:
No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
ACGIH:
No component of this product present at levels greater than or equal to 0.1% is identified as a
carcinogen or potential carcinogen by ACGIH.
NTP:
No component of this product present at levels greater than or equal to 0.1% is identified as a
known or anticipated carcinogen by NTP.
OSHA:
No component of this product present at levels greater than or equal to 0.1% is identified as a
carcinogen or potential carcinogen by OSHA.
Reproductive toxicity
Sigma-Aldrich - P6148
Page 5 of 8
no data available
Teratogenicity
no data available
Specific target organ toxicity - single exposure (Globally Harmonized System)
Inhalation - May cause respiratory irritation.
Specific target organ toxicity - repeated exposure (Globally Harmonized System)
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation
Ingestion
Skin
Eyes
Toxic if inhaled. Causes respiratory tract irritation.
Harmful if swallowed.
Harmful if absorbed through skin. Causes skin irritation.
Causes eye irritation.
Signs and Symptoms of Exposure
May cause irreversible eye damage.
Synergistic effects
no data available
Additional Information
RTECS: RV0540000
12. ECOLOGICAL INFORMATION
Toxicity
Toxicity to daphnia
and other aquatic
invertebrates
EC50 - Daphnia magna (Water flea) - 42 mg/l - 24 h
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
PBT and vPvB assessment
no data available
Other adverse effects
An environmental hazard cannot be excluded in the event of unprofessional handling or disposal.
Harmful to aquatic life.
no data available
13. DISPOSAL CONSIDERATIONS
Sigma-Aldrich - P6148
Page 6 of 8
Product
Contact a licensed professional waste disposal service to dispose of this material. Burn in a chemical incinerator
equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer
surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging
Dispose of as unused product.
14. TRANSPORT INFORMATION
DOT (US)
UN number: 2213 Class: 4.1
Proper shipping name: Paraformaldehyde
Reportable Quantity (RQ): 1000 lbs
Marine pollutant: No
Poison Inhalation Hazard: No
Packing group: III
IMDG
UN number: 2213 Class: 4.1
Packing group: III
Proper shipping name: PARAFORMALDEHYDE
Marine pollutant: No
IATA
UN number: 2213 Class: 4.1
Proper shipping name: Paraformaldehyde
EMS-No: F-A, S-G
Packing group: III
15. REGULATORY INFORMATION
OSHA Hazards
Flammable solid, Target Organ Effect, Toxic by inhalation., Harmful by ingestion., Skin sensitiser, IrritantFlammable solid,
Target Organ Effect, Toxic by inhalation., Harmful by ingestion., Skin sensitiser, Irritant, Carcinogen
SARA 302 Components
SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components
SARA 313: This material does not contain any chemical components with known CAS numbers that exceed the threshold
(De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards
Fire Hazard, Acute Health Hazard, Chronic Health Hazard
Massachusetts Right To Know Components
Paraformaldehyde
CAS-No.
30525-89-4
Revision Date
2007-03-01
CAS-No.
30525-89-4
Revision Date
2007-03-01
CAS-No.
30525-89-4
Revision Date
2007-03-01
Pennsylvania Right To Know Components
Paraformaldehyde
New Jersey Right To Know Components
Paraformaldehyde
California Prop. 65 Components
This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other
reproductive harm.
16. OTHER INFORMATION
Further information
Copyright 2012 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only.
Sigma-Aldrich - P6148
Page 7 of 8
The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a
guide. The information in this document is based on the present state of our knowledge and is applicable to the
product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the
product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or
from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for
additional terms and conditions of sale.
Sigma-Aldrich - P6148
Page 8 of 8
SIGMA-ALDRICH
sigma-aldrich.com
Material Safety Data Sheet
Version 4.2
Revision Date 04/19/2013
Print Date 12/06/2013
1. PRODUCT AND COMPANY IDENTIFICATION
Product name
:
Formalin solution, neutral buffered, 10%
Product Number
Brand
:
:
HT501128
Sigma
Supplier
:
Telephone
Fax
Emergency Phone # (For
both supplier and
manufacturer)
Preparation Information
:
:
:
Sigma-Aldrich
3050 Spruce Street
SAINT LOUIS MO 63103
USA
+1 800-325-5832
+1 800-325-5052
(314) 776-6555
:
Sigma-Aldrich Corporation
Product Safety - Americas Region
1-800-521-8956
2. HAZARDS IDENTIFICATION
Emergency Overview
OSHA Hazards
Combustible Liquid, Carcinogen, Target Organ Effect, Toxic by inhalation., Toxic by ingestion, Toxic by skin
absorption, Skin sensitiser, Irritant, Corrosive
Target Organs
Eyes, Kidney, Liver, Heart, Central nervous system
GHS Classification
Flammable liquids (Category 4)
Acute toxicity, Oral (Category 4)
Skin irritation (Category 2)
Serious eye damage (Category 1)
Skin sensitisation (Category 1)
Carcinogenicity (Category 2)
Specific target organ toxicity - single exposure (Category 1)
GHS Label elements, including precautionary statements
Pictogram
Signal word
Hazard statement(s)
H227
H302
H315
H317
H318
H351
H370
Danger
Combustible liquid
Harmful if swallowed.
Causes skin irritation.
May cause an allergic skin reaction.
Causes serious eye damage.
Suspected of causing cancer.
Causes damage to organs.
Precautionary statement(s)
P260
Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
Sigma - HT501128
Page 1 of 8
P280
P305 + P351 + P338
P307 + P311
Wear protective gloves/ eye protection/ face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing.
IF exposed: Call a POISON CENTER or doctor/ physician.
HMIS Classification
Health hazard:
Chronic Health Hazard:
Flammability:
Physical hazards:
3
*
2
0
NFPA Rating
Health hazard:
Fire:
Reactivity Hazard:
3
2
0
Potential Health Effects
Inhalation
Skin
Eyes
Ingestion
Toxic if inhaled. Material is extremely destructive to the tissue of the mucous
membranes and upper respiratory tract. Causes respiratory tract irritation.
Toxic if absorbed through skin. Causes skin burns. Causes skin irritation.
Causes eye burns. Causes eye irritation.
Toxic if swallowed.
3. COMPOSITION/INFORMATION ON INGREDIENTS
Component
Classification
Concentration
Formaldehyde
CAS-No.
EC-No.
Index-No.
50-00-0
200-001-8
605-001-00-5
Acute Tox. 3; Skin Corr. 1B;
Skin Sens. 1; Carc. 2; H301 +
H311 + H331, H314, H317,
H351
1-5%
Methanol
CAS-No.
EC-No.
Index-No.
Registration number
67-56-1
200-659-6
603-001-00-X
01-2119433307-44-XXXX
Flam. Liq. 2; Acute Tox. 3;
STOT SE 1; H225, H301 +
H311 + H331, H370
1-5%
For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16
4. FIRST AID MEASURES
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.Move out of dangerous area.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.Continue rinsing eyes during
transport to hospital.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a
physician.
5. FIREFIGHTING MEASURES
Conditions of flammability
Flammable in the presence of a source of ignition when the temperature is above the flash point. Keep away from
heat/sparks/open flame/hot surface. No smoking.
Sigma - HT501128
Page 2 of 8
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special protective equipment for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Hazardous combustion products
Hazardous decomposition products formed under fire conditions. - Carbon oxides
Further information
Use water spray to cool unopened containers.
6. ACCIDENTAL RELEASE MEASURES
Personal precautions
Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all
sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive
concentrations. Vapours can accumulate in low areas.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in
container for disposal according to local regulations (see section 13). Keep in suitable, closed containers for disposal.
7. HANDLING AND STORAGE
Precautions for safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.
Conditions for safe storage
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed
and kept upright to prevent leakage.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Components with workplace control parameters
Components
CAS-No.
Value
Control
parameters
0.3 ppm
Basis
Formaldehyde
50-00-0
C
Remarks
Eye & Upper Respiratory Tract irritation Suspected human carcinogen Sensitizer
USA. ACGIH Threshold Limit Values (TLV)
Substance listed; for more information see OSHA document 1910.1048
Substance listed; for more information see OSHA document 1910.1048
See 1910.1048
TWA
0.016 ppm
USA. NIOSH Recommended Exposure Limits
Potential Occupational Carcinogen See Appendix A
C
0.1 ppm
USA. NIOSH Recommended Exposure Limits
Potential Occupational Carcinogen See Appendix A 15 minute ceiling value
TWA
0.016 ppm
USA. NIOSH Recommended Exposure Limits
Potential Occupational Carcinogen Formalin is an aqueous solution that is 37% formaldehyde by
weight; inhibited solutions usually contain 6-12% methyl alcohol. Also see specific listings for
Sigma - HT501128
Page 3 of 8
Formaldehyde and Methyl alcohol. See Appendix A
C
0.1 ppm
USA. NIOSH Recommended Exposure Limits
Potential Occupational Carcinogen Formalin is an aqueous solution that is 37% formaldehyde by
weight; inhibited solutions usually contain 6-12% methyl alcohol. Also see specific listings for
Formaldehyde and Methyl alcohol. See Appendix A 15 minute ceiling value
Methanol
67-56-1
TWA
Remarks
Headache Eye damage Substances for which there is a Biological Exposure Index or Indices (see
BEI® section) Danger of cutaneous absorption
STEL
200 ppm
250 ppm
USA. ACGIH Threshold Limit Values (TLV)
USA. ACGIH Threshold Limit Values (TLV)
Headache Eye damage Substances for which there is a Biological Exposure Index or Indices (see
BEI® section) Danger of cutaneous absorption
TWA
200 ppm
260 mg/m3
USA. OSHA - TABLE Z-1 Limits for Air Contaminants 1910.1000
STEL
250 ppm
325 mg/m3
USA. OSHA - TABLE Z-1 Limits for Air Contaminants 1910.1000
Skin notation
Skin notation
TWA
200 ppm
260 mg/m3
The value in mg/m3 is approximate.
USA. Occupational Exposure Limits (OSHA) - Table Z-1
Limits for Air Contaminants
TWA
USA. NIOSH Recommended Exposure Limits
ST
USA. NIOSH Recommended Exposure Limits
200 ppm
260 mg/m3
Potential for dermal absorption
250 ppm
325 mg/m3
Potential for dermal absorption
Personal protective equipment
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose
combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the
respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components
tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Hand protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching
glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in
accordance with applicable laws and good laboratory practices. Wash and dry hands.
Eye protection
Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved
under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin and body protection
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the
concentration and amount of the dangerous substance at the specific workplace.
Hygiene measures
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of
workday.
Sigma - HT501128
Page 4 of 8
9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance
Form
liquid
Colour
no data available
Safety data
pH
no data available
Melting
point/freezing point
no data available
Boiling point
100 °C (212 °F) at 1,013 hPa (760 mmHg)
Flash point
85 °C (185 °F)
Ignition temperature
no data available
Auto-ignition
temperature
no data available
Lower explosion limit
7 %(V)
Upper explosion limit
70 %(V)
Vapour pressure
53 hPa (40 mmHg) at 39 °C (102 °F)
Density
1.080 g/cm3
Water solubility
completely miscible
Partition coefficient:
n-octanol/water
no data available
Relative vapour
density
no data available
Odour
no data available
Odour Threshold
no data available
Evapouration rate
no data available
10. STABILITY AND REACTIVITY
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
no data available
Conditions to avoid
Heat, flames and sparks.
Materials to avoid
Strong bases, Acids, Oxidizing agents, Alkali metals, Strong oxidizing agents, Amines, Strong acids, Acid chlorides, Acid
anhydrides, Reducing agents, Peroxides, Isocyanates, Phenol, Aniline
Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides
Other decomposition products - no data available
11. TOXICOLOGICAL INFORMATION
Acute toxicity
Oral LD50
no data available
Inhalation LC50
no data available
Sigma - HT501128
Page 5 of 8
Dermal LD50
no data available
Other information on acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
Eyes: no data available
Respiratory or skin sensitisation
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC:
1 - Group 1: Carcinogenic to humans (Formaldehyde)
NTP:
Known to be human carcinogen (Formaldehyde)
Reproductive toxicity
no data available
Teratogenicity
no data available
Specific target organ toxicity - single exposure (Globally Harmonized System)
no data available
Specific target organ toxicity - repeated exposure (Globally Harmonized System)
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation
Ingestion
Skin
Eyes
Toxic if inhaled. Material is extremely destructive to the tissue of the mucous membranes
and upper respiratory tract. Causes respiratory tract irritation.
Toxic if swallowed.
Toxic if absorbed through skin. Causes skin burns. Causes skin irritation.
Causes eye burns. Causes eye irritation.
Signs and Symptoms of Exposure
Methyl alcohol may be fatal or cause blindness if swallowed., Cannot be made non-poisonous., Effects due to ingestion
may include:, Nausea, Dizziness, Gastrointestinal disturbance, Weakness, Confusion., Drowsiness, Unconsciousness,
May cause convulsions.
Synergistic effects
no data available
Additional Information
RTECS: Not available
12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Sigma - HT501128
Page 6 of 8
Bioaccumulative potential
no data available
Mobility in soil
no data available
PBT and vPvB assessment
no data available
Other adverse effects
no data available
13. DISPOSAL CONSIDERATIONS
Product
This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber. Offer
surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal
service to dispose of this material.
Contaminated packaging
Dispose of as unused product.
14. TRANSPORT INFORMATION
DOT (US)
NA-Number: 1993 Class: CBL
Packing group: III
Proper shipping name: Combustible liquid, n.o.s. (Formaldehyde, Methanol)
Reportable Quantity (RQ): 2500 lbs
Marine pollutant: No
Poison Inhalation Hazard: No
IMDG
Not dangerous goods
IATA
Not dangerous goods
15. REGULATORY INFORMATION
OSHA Hazards
Combustible Liquid, Carcinogen, Target Organ Effect, Toxic by inhalation., Toxic by ingestion, Toxic by skin absorption,
Skin sensitiser, Irritant, Corrosive
SARA 302 Components
The following components are subject to reporting levels established by SARA Title III, Section 302:
CAS-No.
Revision Date
Formaldehyde
50-00-0
2007-07-01
SARA 313 Components
The following components are subject to reporting levels established by SARA Title III, Section 313:
CAS-No.
Revision Date
Methanol
67-56-1
2007-07-01
Formaldehyde
50-00-0
2007-07-01
SARA 311/312 Hazards
Fire Hazard, Acute Health Hazard, Chronic Health Hazard
Massachusetts Right To Know Components
Formaldehyde
Methanol
CAS-No.
50-00-0
67-56-1
Revision Date
2007-07-01
2007-07-01
CAS-No.
7732-18-5
Revision Date
Pennsylvania Right To Know Components
Water
Sigma - HT501128
Page 7 of 8
Formaldehyde
Methanol
Disodium hydrogenorthophosphate
50-00-0
67-56-1
7558-79-4
2007-07-01
2007-07-01
2007-03-01
CAS-No.
7732-18-5
50-00-0
67-56-1
Revision Date
CAS-No.
50-00-0
Revision Date
2007-09-28
New Jersey Right To Know Components
Water
Formaldehyde
Methanol
California Prop. 65 Components
WARNING! This product contains a chemical known to the State of
California to cause cancer.
Formaldehyde
2007-07-01
2007-07-01
16. OTHER INFORMATION
Text of H-code(s) and R-phrase(s) mentioned in Section 3
Acute Tox.
Carc.
Flam. Liq.
H225
H301 + H311 +
H331
H314
H317
H351
H370
Skin Corr.
Skin Sens.
STOT SE
Acute toxicity
Carcinogenicity
Flammable liquids
Highly flammable liquid and vapour.
Toxic if swallowed, in contact with skin or if inhaled
Causes severe skin burns and eye damage.
May cause an allergic skin reaction.
Suspected of causing cancer.
Causes damage to organs.
Skin corrosion
Skin sensitisation
Specific target organ toxicity - single exposure
Further information
Copyright 2013 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only.
The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a
guide. The information in this document is based on the present state of our knowledge and is applicable to the
product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the
product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or
from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for
additional terms and conditions of sale.
Sigma - HT501128
Page 8 of 8
SIGMA-ALDRICH
sigma-aldrich.com
Material Safety Data Sheet
Version 4.5
Revision Date 05/10/2012
Print Date 12/06/2013
1. PRODUCT AND COMPANY IDENTIFICATION
Product name
:
Formaldehyde solution
Product Number
Brand
:
:
433284
Aldrich
Supplier
:
Telephone
Fax
Emergency Phone # (For
both supplier and
manufacturer)
Preparation Information
:
:
:
Sigma-Aldrich
3050 Spruce Street
SAINT LOUIS MO 63103
USA
+1 800-325-5832
+1 800-325-5052
(314) 776-6555
:
Sigma-Aldrich Corporation
Product Safety - Americas Region
1-800-521-8956
2. HAZARDS IDENTIFICATION
Emergency Overview
OSHA Hazards
Combustible Liquid, Skin sensitiser, Carcinogen, Target Organ Effect, Toxic by inhalation., Toxic by ingestion, Toxic
by skin absorption, Corrosive
Target Organs
Eyes, Kidney, Liver, Heart, Central nervous system
GHS Classification
Flammable liquids (Category 4)
Acute toxicity, Oral (Category 3)
Acute toxicity, Inhalation (Category 3)
Acute toxicity, Dermal (Category 3)
Skin irritation (Category 2)
Serious eye damage (Category 1)
Respiratory sensitization (Category 1)
Skin sensitization (Category 1)
Carcinogenicity (Category 2)
Specific target organ toxicity - single exposure (Category 1)
Acute aquatic toxicity (Category 3)
GHS Label elements, including precautionary statements
Pictogram
Signal word
Hazard statement(s)
H227
H301 + H311 + H331
H315
H317
H318
Aldrich - 433284
Danger
Combustible liquid
Toxic if swallowed, in contact with skin or if inhaled
Causes skin irritation.
May cause an allergic skin reaction.
Causes serious eye damage.
Page 1 of 8
H334
H351
H370
H402
Precautionary statement(s)
P260
P280
P301 + P310
P305 + P351 + P338
P307 + P311
May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Suspected of causing cancer.
Causes damage to organs.
Harmful to aquatic life.
Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
Wear protective gloves/ eye protection/ face protection.
IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing.
IF exposed: Call a POISON CENTER or doctor/ physician.
HMIS Classification
Health hazard:
Chronic Health Hazard:
Flammability:
Physical hazards:
3
*
2
0
NFPA Rating
Health hazard:
Fire:
Reactivity Hazard:
3
2
0
Potential Health Effects
Inhalation
Skin
Eyes
Ingestion
Toxic if inhaled. Material is extremely destructive to the tissue of the mucous
membranes and upper respiratory tract.
Toxic if absorbed through skin. Causes skin burns.
Causes eye burns.
Toxic if swallowed.
3. COMPOSITION/INFORMATION ON INGREDIENTS
Synonyms
:
Formalin
Molecular Weight
:
30.03 g/mol
Component
Classification
Concentration
Formaldehyde
CAS-No.
EC-No.
Index-No.
50-00-0
200-001-8
605-001-00-5
Acute Tox. 3; Skin Corr. 1B;
Skin Sens. 1; Carc. 2; H301 +
H311 + H331, H314, H317,
H351
30 - 50 %
Methanol
CAS-No.
EC-No.
Index-No.
Registration number
67-56-1
200-659-6
603-001-00-X
01-2119433307-44-XXXX
Flam. Liq. 2; Acute Tox. 3;
STOT SE 1; H225, H301 +
H311 + H331, H370
10 - 30 %
For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16
4. FIRST AID MEASURES
General advice
Move out of dangerous area.Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.
In case of eye contact
Continue rinsing eyes during transport to hospital.Rinse thoroughly with plenty of water for at least 15 minutes and
consult a physician.
Aldrich - 433284
Page 2 of 8
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a
physician.
5. FIREFIGHTING MEASURES
Conditions of flammability
Flammable in the presence of a source of ignition when the temperature is above the flash point. Keep away from
heat/sparks/open flame/hot surface. No smoking.
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special protective equipment for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Hazardous combustion products
Hazardous decomposition products formed under fire conditions. - Carbon oxides
Further information
Use water spray to cool unopened containers.
6. ACCIDENTAL RELEASE MEASURES
Personal precautions
Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of
ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours
can accumulate in low areas.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment
must be avoided.
Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in
container for disposal according to local regulations (see section 13). Keep in suitable, closed containers for disposal.
7. HANDLING AND STORAGE
Precautions for safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.
Conditions for safe storage
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed
and kept upright to prevent leakage.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Components with workplace control parameters
Components
CAS-No.
Value
Control
parameters
0.3 ppm
Basis
Formaldehyde
50-00-0
C
Remarks
Eye & Upper Respiratory Tract irritation Suspected human carcinogen Sensitizer
USA. ACGIH Threshold Limit Values (TLV)
Substance listed; for more information see OSHA document 1910.1048
Substance listed; for more information see OSHA document 1910.1048
See 1910.1048
TWA
Aldrich - 433284
0.016 ppm
USA. NIOSH Recommended Exposure Limits
Page 3 of 8
Potential Occupational Carcinogen See Appendix A 15 minute ceiling value
C
0.1 ppm
USA. NIOSH Recommended Exposure Limits
Potential Occupational Carcinogen See Appendix A 15 minute ceiling value
TWA
0.016 ppm
USA. NIOSH Recommended Exposure Limits
Potential Occupational Carcinogen Formalin is an aqueous solution that is 37% formaldehyde by
weight; inhibited solutions usually contain 6-12% methyl alcohol. Also see specific listings for
Formaldehyde and Methyl alcohol. See Appendix A 15 minute ceiling value
C
0.1 ppm
USA. NIOSH Recommended Exposure Limits
Potential Occupational Carcinogen Formalin is an aqueous solution that is 37% formaldehyde by
weight; inhibited solutions usually contain 6-12% methyl alcohol. Also see specific listings for
Formaldehyde and Methyl alcohol. See Appendix A 15 minute ceiling value
Methanol
67-56-1
TWA
Remarks
Headache Eye damage Substances for which there is a Biological Exposure Index or Indices (see
BEI® section) Danger of cutaneous absorption
STEL
200 ppm
250 ppm
USA. ACGIH Threshold Limit Values (TLV)
USA. ACGIH Threshold Limit Values (TLV)
Headache Eye damage Substances for which there is a Biological Exposure Index or Indices (see
BEI® section) Danger of cutaneous absorption
TWA
200 ppm
260 mg/m3
USA. OSHA - TABLE Z-1 Limits for Air Contaminants 1910.1000
STEL
250 ppm
325 mg/m3
USA. OSHA - TABLE Z-1 Limits for Air Contaminants 1910.1000
Skin notation
Skin notation
TWA
200 ppm
260 mg/m3
The value in mg/m3 is approximate.
USA. Occupational Exposure Limits (OSHA) - Table Z-1
Limits for Air Contaminants
TWA
USA. NIOSH Recommended Exposure Limits
ST
USA. NIOSH Recommended Exposure Limits
200 ppm
260 mg/m3
Potential for dermal absorption
250 ppm
325 mg/m3
Potential for dermal absorption
Personal protective equipment
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose
combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the
respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components
tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Hand protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching
glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in
accordance with applicable laws and good laboratory practices. Wash and dry hands.
Aldrich - 433284
Page 4 of 8
Eye protection
Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved
under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin and body protection
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the
concentration and amount of the dangerous substance at the specific workplace.
Hygiene measures
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.
9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance
Form
liquid, clear
Colour
colourless
Safety data
pH
no data available
Melting
point/freezing point
no data available
Boiling point
100 °C (212 °F)
Flash point
64 °C (147 °F) - closed cup
Ignition temperature
420 °C (788 °F)
Autoignition
temperature
no data available
Lower explosion limit
7 %(V)
Upper explosion limit
70 %(V)
Vapour pressure
53 hPa (40 mmHg) at 39 °C (102 °F)
Density
1.090 g/cm3
Water solubility
completely soluble
Partition coefficient:
n-octanol/water
log Pow: 0.35
Relative vapour
density
1.04
- (Air = 1.0)
Odour
pungent
Odour Threshold
no data available
Evaporation rate
1
10. STABILITY AND REACTIVITY
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
no data available
Conditions to avoid
Heat, flames and sparks.
Materials to avoid
Strong oxidizing agents, Aniline, Phenol, Isocyanates, Acid anhydrides, Strong acids, Strong bases, Amines, Peroxides,
Acid chlorides, Alkali metals, Reducing agents
Aldrich - 433284
Page 5 of 8
Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides
Other decomposition products - no data available
11. TOXICOLOGICAL INFORMATION
Acute toxicity
Oral LD50
no data available
Inhalation LC50
no data available
Dermal LD50
no data available
Other information on acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
Eyes: no data available
Respiratory or skin sensitization
May cause allergic skin reaction.
Germ cell mutagenicity
no data available
Carcinogenicity
IARC:
1 - Group 1: Carcinogenic to humans (Formaldehyde)
NTP:
Reasonably anticipated to be a human carcinogen (Formaldehyde)
Reproductive toxicity
no data available
Teratogenicity
no data available
Specific target organ toxicity - single exposure (Globally Harmonized System)
no data available
Specific target organ toxicity - repeated exposure (Globally Harmonized System)
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation
Ingestion
Skin
Eyes
Toxic if inhaled. Material is extremely destructive to the tissue of the mucous membranes
and upper respiratory tract.
Toxic if swallowed.
Toxic if absorbed through skin. Causes skin burns.
Causes eye burns.
Signs and Symptoms of Exposure
burning sensation, Cough, wheezing, laryngitis, Shortness of breath, spasm, inflammation and edema of the larynx,
spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, Material is extremely destructive to
tissue of the mucous membranes and upper respiratory tract, eyes, and skin.
Aldrich - 433284
Page 6 of 8
Synergistic effects
no data available
Additional Information
RTECS: Not available
12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
PBT and vPvB assessment
no data available
Other adverse effects
An environmental hazard cannot be excluded in the event of unprofessional handling or disposal.
Harmful to aquatic life.
13. DISPOSAL CONSIDERATIONS
Product
This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber. Offer
surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal
service to dispose of this material.
Contaminated packaging
Dispose of as unused product.
14. TRANSPORT INFORMATION
DOT (US)
UN number: 2209 Class: 8
Packing group: III
Proper shipping name: Formaldehyde solutions
Reportable Quantity (RQ): 286 lbs
Marine pollutant: No
Poison Inhalation Hazard: No
IMDG
UN number: 2209 Class: 8
Packing group: III
Proper shipping name: FORMALDEHYDE SOLUTION
Marine pollutant: No
EMS-No: F-A, S-B
IATA
UN number: 2209 Class: 8
Packing group: III
Proper shipping name: Formaldehyde solution
15. REGULATORY INFORMATION
OSHA Hazards
Combustible Liquid, Skin sensitiser, Carcinogen, Target Organ Effect, Toxic by inhalation., Toxic by ingestion, Toxic by
skin absorption, Corrosive
SARA 302 Components
The following components are subject to reporting levels established by SARA Title III, Section 302:
CAS-No.
Revision Date
Formaldehyde
50-00-0
2007-07-01
Aldrich - 433284
Page 7 of 8
SARA 313 Components
The following components are subject to reporting levels established by SARA Title III, Section 313:
CAS-No.
Revision Date
Methanol
67-56-1
2007-07-01
Formaldehyde
50-00-0
2007-07-01
SARA 311/312 Hazards
Fire Hazard, Acute Health Hazard, Chronic Health Hazard
Massachusetts Right To Know Components
Formaldehyde
Methanol
CAS-No.
50-00-0
67-56-1
Revision Date
2007-07-01
2007-07-01
CAS-No.
7732-18-5
50-00-0
67-56-1
Revision Date
CAS-No.
7732-18-5
50-00-0
67-56-1
Revision Date
CAS-No.
50-00-0
Revision Date
2007-09-28
Pennsylvania Right To Know Components
Water
Formaldehyde
Methanol
2007-07-01
2007-07-01
New Jersey Right To Know Components
Water
Formaldehyde
Methanol
California Prop. 65 Components
WARNING! This product contains a chemical known to the State of
California to cause cancer.
Formaldehyde
2007-07-01
2007-07-01
16. OTHER INFORMATION
Text of H-code(s) and R-phrase(s) mentioned in Section 3
Acute Tox.
Carc.
Flam. Liq.
H225
H301 + H311 +
H331
H314
H317
H351
H370
Skin Corr.
Skin Sens.
STOT SE
Acute toxicity
Carcinogenicity
Flammable liquids
Highly flammable liquid and vapour.
Toxic if swallowed, in contact with skin or if inhaled
Causes severe skin burns and eye damage.
May cause an allergic skin reaction.
Suspected of causing cancer.
Causes damage to organs.
Skin corrosion
Skin sensitization
Specific target organ toxicity - single exposure
Further information
Copyright 2012 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only.
The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a
guide. The information in this document is based on the present state of our knowledge and is applicable to the
product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the
product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or
from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for
additional terms and conditions of sale.
Aldrich - 433284
Page 8 of 8