HORSE GENE MAP
A FIRST GENERATION RADIATION HYBRID MAP AND A HORSE-HUMAN-MOUSE COMPARATIVE MAP
Synteny
map
FISH
map
0
1CA44
20
1CA30
0
18
17
16
CHA1
1CA44
1CA30
ACTA2
PAX2
RBP4/ASB41
DNTT
COL17A1
LEX020?
CYP17
14.3
14.2
14.1
FES
IGF1R
INSR
MYH6
MYH7
13
SLC30A4
COR059
UCD487
VHL134
OAT
12.3
12.2
12.1
11
11
12
1CA16
1CA20
1CA24
1CA25
1CA30
ASB08
SG02/SG25
AHT021/1CA20
MEF2A/FES
PACE
AHT040/1CA41
16
COR006
COR046
COR053
COR046
LEX058
TJP1
17.1
COR059
COR063
17.2
COR079
17.3
COR100
TKY002
1CA43
1CA25
21.1
HMS07
PK3
21.2
HTG12
LEX20
21.3
LEX30
LEX39
LEX58
LEX77
UM004
ANXA2
MYO5A
GRP58
THBS1
SORD
COR006
HMS7
MYH6
TGM1
ACTC
NP
MGAT2
23
UCD440
UCD487
UCD493
24
UM002
25
UM004
26
27
28
UM043
VHL134
VIAS-H34
LEX020
1CA22
22
100
29
NV031
COR059
0
50
0
20
50
0
50
10
UCD487
VHL134
PLAU
UM002
ANXA7
1CA20
ACTA2
RBP4
DNTT
PAX2
COL17A1
CYP17
OAT
PLAU
ANXA7
TKY007
ASB12
TKY015
TKY013
RET
SG25
AHT040
AHT021
UM041
PACE
FES
1CA32
ASB08
LEX077
1CA41
1CA24
COR046
100
COMT
16.8
16
17.8
89.5
94.2
96.9
101.3
33.8
37.7
40.7
44.6
74.6
19
19
19
19
19
19
7
14
73.9
14
COR079
COR100
RET
104.6
103.4
125.0
150
200
15.9
40
15.5
0
0
50
HFABP-L
MEF2A
FES
PACE
96.8
87.6
87.6
7
7
7
56.6
69.8*
69.8*
IGF1R
95.8
7
57.4
TJP1
25.4
7
54.7
0
13
12
11
11
12
A-14
ASB13
1CA28
COR035
TJP1
COR037
CYP1A2
PK3
PKM2
ANXA2
MYO5A
SORD
GRP58
THBS1
ACTC
HTG12
70.9
68.2
68.2
9
9
9
58.2
56.1
48.1
40.6
39.4
35.2
30.4
9
9
2
2
2
2
70.0
75.7
123.2*
122.3
119.0
114.9
60.2
60.2*
COR043
COR049
COR051
COR094
TKY003
UCD380
14
MYH6
CMA1
MYH6
TGM1
NP
MGAT2
22.3
21.2
22.0
18.3
47.4
14
14
14
12
47.0
46.0
46.7
42.8
12
0
20
1
TKY024
100
HDAC1
150
AHT035
GPR3
HMS54
ASB17
UM007
200
HMS51
ALPL
ECE1
HP1-BP74
250
EIF4G3
23.7
30.9
32.5
23.6
27.8
15.1
21.4
25.2
28.7
21.1
20.6
20.7
67.4
126.7
116.9
133.5*
128.4
127.0
133.5
130.7*
15
139.5
135.3
132.4
13
135.5*
135.8
135.6*
ADH3
4
4
143.3*
144.5*
FGFR3
KARS
MTP
3
100.7
CLU
27.2
57.0
FGG
FABP3
200
4
COR094
3
156.3
31.6
SMARCA5
IL2
4
83.7
124.2
UCD437
80.3*
37.0
20
14.3
ALB
PDGFRA
F11 ?
KIT
22.1
22.2
22.3
350
FN1
INHA
15
14
FN1
13
GAPD
IFNG
SCG2
12
UGT1A1
MAP2
11
11
12
PAX3
PFKM
50
CSN1,2
50
150
0
ASB23
UCHL1
TPI1
MAP2
2
CUL3
COR010
150
LEX065
214.4
208.7
218.4
1
1
1
72.2
66.9
76.3
PAX3
SCG2
CUL3
UGT1A1
CHRNG
221.1
1
1
1
1
1
78.9
0
13
50
222.4
223.3
232.6
231.4
80.3
81.1
88.6
87.6
TXK
CCK
ADD1
24
25
26
100
COR026
5.9
100
21.3
150
HTG31
RKJ06
TRA1
22
LEX65
UCD465
IFNG
SILV
23
UM015
14.3
14.2
14.1
200
250
UM015
COR004
12
TKY111
PFKM
48.5
NV081
15
99.0
UCD465
TRA1
103.4
10
86.8
COR070
PKFM
IFNG
MAN1
WIF1
SILV
68.0
10
10
10
10
118.5
RKJ06
64.9
64.9
56.2
350
0
TKY272
50
LEX045
14
SG28
15
19
121.2
121.2
129.3
18
7
MAN1
WIF1
SG28
150
17
IFNG
TKY282
COX8
16
115.6
19.5
121.2
119.0
119.0
17
9
9
9
9
9
9
7
9
9
9
UMNe74
11
HBB
HBB
HBE1
POU2F2
OPCML
LYVE-1
INSL3
CNTF
PAX6
BDNF
WT1
Mouse
Human Draft
sequence Chromosome &
Draft sequence
location
location
FISH
map
Synteny
map
RH
map
57.7
8 105.0
KCC1
58.6
8 105.7
GLG1
KARS
65.4
66.5
8 111.0
8 111.9
DPEP1
MC1R
81.0
81.3
8 123.2
8 123.4
Human
homology
Mouse
Human Draft
sequence chromosome &
Draft sequence
location
location
ADH2/ADH3
LOC51170
EN2
4
3 138.9
3 138.7
3 141.7
LOC51170
HNRPDL
88.4
COR089
83.2
5 101.6*
5 97.5
CCNI
77.8
5
HMS09
ALB
PDGFRA
KIT
CCNI
TCRG
100.4
100.5
96.9
73.9
54.8
55.3
5
5
5
92.8
90.0
74.4
74.8
COR047
HMS06
CSN1,2
UCHL1
ASB23
UCHL1
3
TXK
CCK
ADD1
21.2
LEX33
41.3
5
65.7
LEX50
41.5
2.8
5
71.8
9 122.9
5 33.2
ASB03
HGF
LAMB1
0
200
TUB
LYVE-1
250
19
PTH
19
300
AHT019
350
11
NR1H2
TYR
COX8
WT1
OPCML
HBB
HBE1
POU2F2
TUB
LYVE-1
PTH
INSL3
CNTF
PAX6
BDNF
51.5
91.2
66.1
34.0
134.4
5.9
6.0
43.2
8.8
11.5
14.7
18.4
60.7
33.4
29.0
PAX6
7
7
19
2
9
7
7
7
7
7
7
8
19
2
2
BCR
AHT025
CCND2
LIMK2
LIF
NOS1
SART3
17
16
15
TCF1
TYMS
AHT05
34.1
77.1
ASB14
COR003
COR012
106.0
28.5*
93.4
93.6
17.3
98.5
100.4
102.9
COR056
COR097
LEX23
LEX29
SG32
UCD046
UM033
12.2
106.5
110.6
UM070
14
13
12
11
11
12
HPD
LEX023
ASB38
TYMS
NPC1
13
LAMA3
CDH2
DSG2
14
15
16
SG32
21.1
21.2
21.3
22
23
100
150
0
50
100
150
0
50
PAI2
8
150
13
18.7
GCK
43.8
11 71.1
AT3
ASB03
UMNe54
COR089
HGF
COL1A2
79.8
92.5
5
6
14.9
4.2
LEX033
LAMB1
106.0
12
LAMC1
18
17
TKY041
LAMC2
16
AHT024
15
PTGS2
LAMB3
HMS76
NGFB
14
VCAM1
13
11
11
12
AHT013
LEX050
7
COR023
ASB29
HMS05
HTG09
200
HMS19
CFTR
HTG09
AKR1B1
CFTR
LEP
0
CLCN1
OPN1SW
EN2
SG23
HTG15
COL1A2
HMS09
COR047
HMS62
CLCN1
50
LEP
MEST
AKR1B1
126.3
128.6
132.4
6 29.0
6 30.7*
6 34.4
OPN1SW
CLCN1
EN2
126.8
141.3
153.4
6 29.3
6 42.4*
5 26.6
6 18.1
ATP1A1
VCAM1
IGL@
TSHB
13
14
LEX14
0
UBE2L3
AHT025
22
TCF1
SART3
UMNe70
UCD046
12
FLJ11021
LEX023
UBE2L3
BCR
LIF
LIMK2
CCND2
TCF1
NOS1
SART3
HPD
FLJ11021
18.6
20.2
27.3
28.3
4.1
120.2
116.6
108.0
121.1
121.6
16 16.6
10 75.4*
11 4.1
1 3.2
6
5
5
5
5
5
128.0
112.9
115.8
111.6
50
UOX
UCD304 16
LEX014
PTGS2
VHL66
0
PKLR
GBA
50
CTSK
0
ARPC3
10.0
17 64.6
TYMS
0.9
5 28.5
COR013
NPC1
21.0
18 12.2
COR093
VAPA
LAMA3
21.3
18 12.3
COR098
ASB14
TYMS
CDH2
DSC2
DSG2
25.4
29.1
29.1
18 16.6
18 20.1
18 20.1
18
12
11
11
12
13
COR008
LEX029
GALR1
74.5
18 82.9
CDH2
HSPC039
44.9
18 77.3*
DSC2
NARS
55.6
18 64.8*
PAI2
61.3
LPL
DEFB1
PLAT
14
HMS03
ANK1
15
100
HTG15
200
0
50
250
50
HMS03
150
LEX19
16
MYC
ASB05
UM037
17
VHL126
COR013
HTG08
SG32
200
250
9
1 108.1*
15
14
ARG1
LEX070
NKX3A
LPL
COR098
COR093
8
HSPC038
OAZIN
AHT053
NOV
18
12
CRH
66.2
3
19.4*
CGA
PRKDC
NKX3A
SFTPC
LPL
DEFB1
PLAT
ANK1
47.8
23.2
15.1*
60.3
CKM
21.7
19.6
6.7
41.4
16
14
14
8
8
8
41.9
8
21.7
HSPC038
OAZIN
NOV
MYC
TG
101.2
102.8
119.4
127.7
132.6
15
15
15
15
15
ARPC3
109.8
61.4
68.2
20.5
21.4
38.6
55.1
62.4
67.1
5 120.4
ASB21
LEX019
300
TG
ASB05
250
SLC7A10
RYR1
GPI
XRCC1
COR045
UCD482
COR048
AHT015
ASB06
LHB/CKM
SG30
COR015
SG20
UM028
COR083
UCD412
LEX062
LEX066
ERCC2
ME1
VHL126
UM037
100
350
GALR1
ASB10
LEX034
205.6
1 131.8
LAMC2
AT3
LAMC1
PRG4
PTGS2
LAMB3
PKLR
GBA
CTSK
VDUP1
GJA5
S100A6
L16464
CD2
NFIA
ATP1A1
NGFB
180.6
171.4
180.5
183.7
184.1
208.4
153.1
153.0
148.6
143.9
145.4
146.47
154.9
117.8
61.4
117.4
116.2
1
1
1
1
1
1
3
3
3
3
3
3
154.0
162.1
154.1
151.3
150.9
194.8
89.9
90.0
95.7
96.8
97.3
91.4
101.3
95.5
101.6
102.5
VCAM1
IGL@
3
4
3
3
101.9
3
19.2
16
TSHB
NRAS
SH3GLB1
115.9
115.6
87.7
3 102.8
3 103.1
3 45.2
3 147.1
UOX
22
116.4
18.5
DIA1
39.6
15
SLC7A10
GPI
RYR1
XRCC1
CKM
LHB
ERCC2
34.3
35.4
39.5
44.6
46.4
50.1
46.4
7
7
7
7
7
7
7
25.6
24.6
21.2
16.7
14.4
34.9
14.3
CGA
ME1
AMD1
4
4
9
111.0 10
32.2
34.5
87.5
COL10A1
116.2
10 34.3
ARG1
131.5
10 24.8
PEX7
136.7
10 19.7
83.9
LEX014
RYR1
COR045
AHT096
SFTPC
0
VCAM1
SH3GLB1
0
HTG08
LEX70
COR012
CRH
TKY006?
PRKDC
SFTPC
UCD304
HMS05
300
5
AMD1
13
NGFB
COR023
50
EN2
150
TG
1
IL10
AHT061
AHT042
14
DNAPK
121.2
121.8*
VAPA
100
GJA5
CD2
DIA1
17
COR008
TKY023?
16
15
LAMC1
NRAS
15
HTG22
AT3
PRG4
150
LEX04
LEX34
MEST
0
CFTR
115.5
150
LEX004
VDUP1
VDUP1
S100A6
L16464
CD2
NFIA
12
25.3
HMB6
4
200
SILV
TKY284
37.8
100
SG23
LAMA3
100
TCRG
150
AHT005
UM034
50
16.0
ASB22
HMS19
23
24
26
27
AHT097
50
5
AHT024
GBA
LEX061
22
COR005
78.9
UMNe063
0
SG23
19.4
250
21.3
LEX61
5
HTG07
HMS22
87.2
75.7
200
ASB22
HTG07
HMS06
PTPN12
SEMA3C
GCK
14
21.1
5
150
GCK
13
HMS19
70.7
48.1
50
TCRG
100
HTG09
ALB
KIT
TCRG
12
11
11
12
MEST
ADH2
ADH3
PDHA2
AHT048
16
15
COL1A2
14
CSF2 13
TKY041
IL10
SEMA3C
100
LEP
HMS61
0
AHT043
AHT084
COR097
56.2
21.8
8.8
7.2
46.4
52.2
49.6
36.4
44.3
46.4
46.4
COR095
100
LEX015
6.7
11.3
103.1
105.0
119.0
112.5
LEX045
TYR
13
11
TKY005
HTG33
C3
LDLR
PGR
MMP13
APOA4
FDX1
DRD2
LDHA
THY1
APOC3
APOA1
COR004
TKY005
NR1H2
19
6
TKY34
TKY35
DRD2
TKY12
LEX015
THY1
APOC3
LEX038
TKY283
0
12
11
11
12
24
300
CBFB
50
COR043
0
13
6 126.4
COR010
COR070
15
COR095
21.2
8 8 95.6
8 104.7
LEX057
MC1R
LEX007
3
COR035
19
C3
LDLR
PGR
MMP13
APOA4
TKY034/035
TKY012
FDX1
LDHA
APOC3
APOA1
16
HMS55
VWF
21.1
COR019
APOA4
C3
DRD2
HBB
PTH
THY1
TUB
TYR
CHRNG
VWF
SILV
GLG1
37.9
49.1
57.6
HTG02
0
NV082
200
16
KCC1
HNRPDL
100
COR019
FN1
MAP2
INHA
Human
homology
PTPN12
0
PAX3
100
CBFB
AHT090
50
SMARCA5
0
SG18
KARS
0
23
UMNe 76
0
COR033
UCD437
21
SG18
127.8
8
3
145.2
PHKB
GOT2
CES2
COR005
LEX57
FGG
FABP3
300
PDHA2
COR033
4
1
COR028
14.2
COR028
ASB13
20
FN1
CHRNG
RH
map
NV029
AHT022
14.1
138.5
14
250
400
SPARCL1
4
200
HTG31
0
FISH
map
AHT036
GOT2
SG33
13
LEX07
IL2
11
11
12
CCNI
CLU
150
GLG1
KARS
DPEP1
MC1R
12
ALB
AHT012
2
AHT022
ADD1
4
4
4
150
SG18
14
ADH2
11.9*
10.4
AHT036
GOT2
CES2
16
A-14
21.3
Synteny
map
0
100
FGG
SMARCA5
Mouse
Human Draft
sequence Chromosome &
Draft sequence
location
location
100
MC1R
8
ASB13
21.2
1CA16
COR053
1CA40
COR063
1
4
4
4
4
4
4
4
4
4
4
209.3
32.9
COR049
50
21.1
ACADL
RBBP4
SLC2A1
FUCA1
MATN1
HDAC1
HMGCL
GPR3
ELA2A
ALPL
RHD
D29580
ECE1
HP1-BP74
EIF4G3
NPPA
PGD
A-14(ms)
14.3
NP
1
50
0
22
23
24
25
63.8*
2
HTG19
RBBP4
COR037
COR090
TKY003
COR078
COR078
COR090
50
COR051
14.2
Human
homology
PHKB
ASB18
NPPA
14.1
RH
map
0
300
MTP
FISH
map
Synteny
map
COR041
UCD380
13
COR041
UM007
CMA1
50
15.1
14
COR026
AHT058
150
15.3
NPPA
IGF1R
UM004
ANXA2
UCD440
MY05A
COR006
HMS07
16
ASB17
PKM2
100
18
17
118.9
42.8
ACADL
SLC2A1
FUCA1
MATN1
TKY003
COR078
TKY024
AHT035
HMGCL
GPR3
ASB17
ELA2A/ALPL
RHD/NPPA
D29580
PGD
Mouse
Human Draft
sequence Chromosome &
Draft sequence
location
location
Human
homology
COR065
20
FGG
TKY002
1CA43
1CA25
TKY106
UCD493
CYP1A2
UM043
PK3
RH
map
0
CNK
15
FISH
map
Synteny
map
47.5
46.5
122.5
LEX058
PKM2
22
SG25
0
ASB12
14
15
1CA43
LEX039
0
13
1CA32
50
50
Mouse
Human Draft
Chromosome &
sequence
Draft sequence
location
location
VIASH34
LEX030
ASB41
COMT
15
CYPIA2
Human
homology
RH
map
ARPC3
13
COL10A
PEX7
AHT086
ASB06
ASB09
COR015
COR020
COR045
COR048
COR083
COR085
HMS02
LEX08
LEX09
LEX62
NV067
SG17
SG30
UCD412
UCD482
UM028
12
11
11
12
13
14
100
0
22
PEX7
CGA?
10
AHT015
ASB06
NV018
CKM
50
19
SG30
COR015
100
LEX008
SG20
150
0
COL10A1
SG17
AMD1
ASB09
UM040
21
UCD482
COR048
150
200
15
16
17
COR020
UM028
COR083
UCD412
LEX062/066
CASP8AP2
CGA
CASP8AP2
6
ME1
0
NV007
COL10A1
90.4
87.7
83.8
SG17
50
AMD1
ASB09
100
0
HMS02
40.3
UM040
LEX009
COR085
50
NV067
300
350
COR003
HSPC039
400
Human chromosome color index
0
ALAS2
P4HB
BGN
50
0
ACE
SG22
FASN
UCD039
DDX5
UCD439
TK1
LEX068
MYL4
ACE
SG24
D-8
MYH2
SG13
TKY032/033
TKY010
ACACA
GAS
NF1
OMG
14
ACTG1
EV12A
GH
13
SCN4A
12.3
12.2
12.1
11
11
12
MYL4
NF1
OMG
P4HB
SUI1
13
D-8
14.1
HLM2
14.2
14.3
LEX68
SG13
SG22
UCD439
UCD457
15
16
11
PNMT
SSTR2
RCV1
MAPT
HLM2
GUCY2D
FASN
ACTG1
UCD039
UCD439
NV040
50
0
LEX068
MYL4
ACE
SCN4A
50
0
0
17
GH1
SG24
D-8
SG13
COL1A1
TRAP240
USP6
50
ASB35
TKY033/32
100
NV090
TKY010
EVI2A
150
ZNF207
OMG
75.9
65.8
44.7
61.2
61.6
61.6
11
11
11
11
11
11
MYH2
COL1A1
TRAP240
USP6
ZNF207
GAS
ACACA
EVI2A
NF1
OMG
10.7
47.8
59.7
54.5
30.4
39.4
34.8
29.6
29.6
29.6
11 67.6
- 13 99.4
11 85.6*
11 81.0
11 101.1
11 84.8*
11 80.1
11 80.0
11 80.1
TIM22
SKIP
RCV1
0.9
1.5
10.1
11
11
11
PNMT
MAPT
SSTR2
37.3
43.5
71.0
11 99.1
11 105.0
11 114.5
GUCY2D
TP53
NF1
200
250
P4HB
PDE6G
FASN
ACTG1
TK1
DDX5
MYL4
ACE
SCN4A
GH1
79.2
-
79.4
8.3
8.0
1
11 121.3
11 121.3
11 121.6
11
11
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17 18
19
20
21
22
X
Y
CLCN4
CXorf6
77.0
76.2*
68.2
69.8
70.1
G6PD
ARSC1
XIST
ZFX
ADRBK1
CD20
IGF2
COR009
COR030
COR058
15
14
13
SG10
AHT027
12
11
11
12
50
0
50
AHT045
13
TKY286
SG10
EIF3S8
RKJ12
ELN
AHT027
UCD497
GUSB
HBA
11
CD20
ROM1
SG08
100
ROM1
CHRM1
COOR009
SG10
UCD411
UCD497
AHT027?
CHRM1
IGF2
14
12
TIM22
SKIP
ADRBK1
COR030
150
UCD411
IGF2
ADRBK1
200
CD20
62.2
64.8
65.1
69.5
19
19
19
19
10.5
8.2
8.0
6.5
7 133.0
0.5
ASB01
ASB37
TKY031
MT2A
POR
ELN
CBLN1
15
14
13
12
11
11
12
ASB37
SG03
VHL161
100
0
19
0
20
14
PRM1
15
16
COR058
COR069
VHL161
TKY031
EIF3S8
13
COR069
LEX41
50
0
16
7
MT2A
POR
ELN
47.0
74.1*
72.0
8 93.8
5 134.2
5 133.3
GUSB
64.0
5 128.4
CBLN1
39.7
8
UM030
ELN
GUSB
LEX041
VHL047
ASB37
PRM1
87.1
DMD
OTC
CRSP2
ALAS2
EIF3S8
27.8
7 116.4*
NV098
HBA1
50
AHT099
CLCN4
UCD428
COR074
PRM1
11.1
16
10.2
0
21
HBA1
0.2
11
32.2
HBA1
23
24
25
26
LEX27
LEX28
SG31
VHL081
0
400
SLC6A3
RASA1
AHT029
MGAT1
COR103/104
12
13
14
ADRB2
UM010
SPARC
ADRB2
DPYSL3
UM032
15
CAMK4
16
CSF1R
FGF1
IL3
21
AHT029
CANX
50
COR103/104
UM010
0
50
ADRB2
DPYSL3
UM032
100
VHL209
LEX047
5
HTG29
22.1
COR002
LEX43
22.2
LEX47
22.3
0
LOX
23
CAMK4
VHL209
50
25
27
14
149.3
148.2
13 70.6
13
11
11
11
82.3
49.6
50.7
55.8
18 61.5
18 62.4*
DPYSL3
146.7
18 43.4
FGF1
141.8
18 39.0
IL3
130.9
11 54.7
LOX
121.1
18 52.7
SOD2ps
11
IL1B
PAX8
SPTBN1
SDNSF
AHT02
ASB02
ASB15
0
12
EN1
IL1RN
IL1B
13
14
B-8
LCT
ASB15
21.1
21.2
21.3
COR014
SPTBN1
SDNSF
ASB02
SG21
FSHR
SG06
ASB19
COR042
COR014
23
COR042
CAMK4
110.1
18 33.1
COR075
HMS01
CSPG2
CRTL1
LEX078
HEXB
HMGCR
81.5
81.7
72.7
73.4
13
13
13
13
86.7
86.6
94.5
93.9
100
LEX51
0
50
SG21
IL1RN
IL1B
111.0
110.7
2 24.6
2 130.3
134.2
1 129.0*
6 73.1*
85.7
NV083
2
MDH1
SPTBN1
SDNSF
SDNSF
SG21
FSHR
11 21.5
11 30.0*
63.9
54.7
47.1
17 86.5*
17 88.3
49.2
26
0
27
HTG06
ODC1
11
CP
12
GLB1
13
RARB
RHO
15
TF
16
COR075
HMS01 A
COR014
AHT02
29.7*
3.8
21.1
12
7.8
APOB
ODC1
COR042
25.3
5
12
27.3
10.3
12
17.6
UMPS
50
TFDP2
RARB
TGFBR2
GLB1
CRTAP
AHT038
HRH1
GPX1
LTF
ACAA1
ACPP
ZNF148
ASB42
RBP1
CPA3
NCK1
21.1
COR039
COR052
I-18
LEX48
0
HTG03
AHT037
TGFBR2
HTG13
CAD
POMC
100
14
SLC21A2
HTG03
ASB19
COR077
TKY104
21.2
21.3
22.1
22.2
22.3
100
LEX59
MPZ002
UCD505
23.1
23.2
23.3
24
25
16
TF
KNG ?
I-18
AGTR1
CP
GYG
0
50
11
12
EDN1
F13A1
13
14
CLPS
COL9A1
DOB
ITPR3
HSPA1A
ELA-DRA
TNFA
16
LEX52
21.2
LEX71
UM011
50
ITPR3
UMNe65
100
UM011
21.3
CYP21A2
C4
GSTA1
0
ITPR3
CSNK2B
MUT
50
BF
6
24
20
PIM1
COL9A1
HMS42
CD164
109.5
10 41.5
HSPA1A
31.8
HLA-DRA 32.4
17 34.0
17 33.4
TNFA
31.6
17 34.3
CYP21A2
C4
32.0
33.7
17 33.9
17 33.8
HLA-DQA
HLA-DOB
HLA-DMA
ITPR3
52.6
32.7
32.7
32.9
33.5
MUT
SGP28
CSNK2B
BF
HMS04
49.4
49.6
31.6
31.9
17
17
17
17
33.3*
33.4
33.2
26.3
17 39.9
17 39.7
17 34.2
17 33.9*
LEX071
PIM1
COL9A1
HMS42
37.1
70.8
RHO
TFDP2
126.0
138.6
16
COR091
MG61
47.1
X
4.4
150
ALAS2
XIST
68.8
X
86.2
72.9
200
MAGE-E1
RBM3
ALDH2ps
XIST
UM038
SG31
PGK1
13.9
X 89.0
X 88.8
X 23.9
X 80.9
X 142.2*
98.3
X 116.0
COL4A5
FACL4
PAK3
103.0
104.1
105.6
X 120.7
X 121.5
X 122.9
IGSF1
GPC3
HPRT1
125.0
127.3
35.4*
37.8
128.2
X
X
X
F9
133.1
X
43.0
CXorf6
BGN
G6PD
143.9
146.8
147.8
X
X
X
54.3*
56.7
57.6
4.3
250
50
X
MNK
UMNe60
TKY039
PLP1
LEX013
LEX024
UM001
TKY038
COL4A5
FACL4
150
PAK3
GPC3
HPRT1
LEX003
TKY020
CXorf6
100
72.7
114.3
62.9
VHL081
AHT087
LEX022
IGSF1
50
PGK1
MNK
LAMP2
AR
GLRA2
Figure 1 The first-generation whole-genome radiation hybrid (RH) map in the horse along with a comparative overview of the map in relation
to human and mouse gene maps. (Chowdhary et al.) Genome Res. 13 (4). Each diagram of a chromosome shows a G-banded ideogram (ISCNH 1997).
To the left of the ideogram, all new (red; the present study) and available synteny data are shown. Alphabetically arranged Type I (proximal group) and
Type II (distal group) loci are separated by a gap. To the right of the ideogram, all new (red; this study) and available FISH data are shown. For both synteny
and FISH data, only those Type II loci are shown that are also present on the RH map. The vertical rounded bars in the RH map represent RH groups
(RHMAP 2pt; lod ≥7) are either cytogenetically aligned with anchor markers (shaded) or placed according to available meiotic map results (white). CentiRay
(cR) distances are shown to the left of the bars, and the deduced order of mapped loci is to the right. Framework markers are depicted in bold italics.
Following this, regional homology of individual horse chromosomes (based on mapped Type I loci) with the human genome is shown (colored vertical bars;
see human chromosome color index). Next to the bars, an ordered assembly of all RH (bold italics) and FISH-mappedType I loci in the horse is shown,
along with the golden path location of human and mouse orthologs in the respective draft sequences (http://genome.ucsc.edu; version June 2002 in human
and February 2002 in mouse). Orthologs showing conserved locus order compared to the derived order of equine genes are grouped in boxes demonstrating the degree of gene order conservation (conserved linkages) in human and mouse compared to that seen in the horse. Mouse chromosome number
is shown in bold before the sequence location of each locus. Yellow-shaded horizontal regions represent loci that have preserved gene order (or are
clustered together) in horse, human, and mouse. These clusters signify core ancestral segments. A ? denotes loci with controversial cytogenetic location;
* denotes position of mouse loci deducted fromtightly linked markers.
TKY020
CXorf6
BGN
G6PD
Acknowledgements: This project was funded by grants from the Texas Higher Education Board (ARP 010366-0162-2001), NRICGP/USDA Grant
2000-03510 (LCS), Texas Equine Research Foundation (BPC, LCS), Link Endowment (BPC, LCS), The Morris Animal Foundation and the Dorothy
Russell Havemeyer Foundation (main sponsor of the poster). Additional support was available from the NRSP-8 Coordinators Fund. We are
extremely thankful to Drs. Richard Brandon, Gabriella Lindgren and Imke Tammen for providing equine primer pairs for various markers (see
Table 1). Dee Honeycutt is gratefully
acknowledged for her excellent management of the horse RH panel.
38.6
33.7
6 116.7
9 96.7*
25.1
32.4
14 11.9
9 117.3
9 115.5
9 115.5
GLB1
PDCD6IP
33.1
9 114.7
CRTAP
HRH1
PB1
GPX1
LTF
ACAA1
11.2
51.7
48.7
45.7
AHT014
COR052
LEX048
TGFBR2
3
30.2
32.3
38.0
6
14
9
9
9
115.3
26.2*
109.2
112.1
120.5
ACPP
ZNF148
128.9
9 105.0
121.7
16 33.1
145.5
UCD505
CPA3
RBP1
136.1
3
9
SLC21A2
NCK1
133.5
9 101.0
LEX056
SLC21A2
130.6
9 103.7
LTF
0
50
100
11
12
13
EDNRB
MTMR6
RNF6
ALOX5AP
14
RB1
ASB42
TF
MPZ002
130.4
19.9
98.9
0
50
100
COR032 21.2
0
COR067
21.3
50
BRCA2
HMS41
SGCG
HMS25
HMS41
LEX55
22
LEX76
NV24
23
COR032
UCD014
24
EDNRB
25
100
NV024
AGTR1
145.3
3
MBNL
CP
GYG
145.8
145.6
3
3
19.6
19.8
MBNL
148.9
3
61.1
RNF6
24.8
14
51.3*
CXCR4
5 145.1*
HDAC1?
14
ALOX5AP 29.8
5 148.2*
HOXD
MSTN
BRCA2
5 149.7
NEB
15
31.4
0
PROC
13
TKY019
13
SGCG
21.7
14
52.3
CA014
GLI2
CXCR4
SG07
NEB
COR096
RB1
LEX055
46.8
14
64.1
CXCR4
50
100
HMS46
150
0
COR032
HMS25
EDNRB
76.4
14
95.0
DCT
CHRNA
DZIP1
DCT
93.4
14 109.2
DZIP1
94.5
14 110.1*
150
1 129.1
11
CXCR4
134.5
1 129.3
12
GLI2
UMNe50
SST
200
250
SG07
25
TKY017
AOX1
CD28
MSTN
26
1 119.4
ASB11
2
100
POH1
POH1
HTG28
GCG
150.0
160.2
161.0
2
52.8
2
62.4
2
63.1
TTN
HTG17
COR101
COL3A1
MSTN
COR062
HMS08
I-12
13
AHT041
14
RPS6
15
MITF
ASB07
16
17
SOX2
CHRNA
173.6
2
TTN
COL3A1
MSTN
AOX1
177.4
187.9
189.1
45.9*
53.6
199.6
2
1
1
1
CD28
202.7
1
61.3
74.4
LEX40
TKY004
NDUFS8 ?
21
ASB25
TKY009
25
PROS1
19
HLM3
AHT041
100
19.7
4
84.1
166.9
3
30.6*
MITF
68.5
6
98.8
SOX2
178.1*
3
34.5
SST
184.2
16
23.6
KNG
183.2
16
22.8
16
63.1*
RPS6
TLOC1
AHT094
AHT052
HTG23
150
MPZ03
3
TLOC1
ASB07
HTG24
0
50
LEX040
LEX073
SST
LEX035
100
22
23
24
58.5
I-12
LEX036
LEX73
MPZ003
COR062
9
50
18
LEX36
UCD387
18
I-12
COR092
LEX35
CHRNA
TKY017
150
COR044
NEB
COR096
50
UCD136
118.7
0
ASB07
NEB
TTN
LEX54
UCD387
134.2
HMS46
0
24
SG07
MCM6
32.2
LEX054
GCG
23
HTG28
125.4
AHT080
22
HLM3
MCM6
18
PROC
NV077
TTN
17
20.0*
AHT060
CP
23.8
21
27
COR064
MTMR6
HTG17
HMS25
26
9 103.9
LEX076
TKY102
HMS41
RB1
COR067
12
CHRNA
COR007
COR105
TKY287
MTMR6
COR072
BRCA2
COR007
UCD136
PROC
RNF6
21.1
0
11
UMNe52
15
I-18
150
COR007
MTMR6
COR072
GPX1
0
50
KNG
TKY004
COR044
HMS08
ASB25
NV011
ZNF-U69274 98.0
COR092
PROS1
90.3
ASB11
100
TKY009
ZNF-U69274
AHT055
0
17 28.7
1 24.5
50
AHT030
AHT095
0
0
CTLA3
GHR
IL7R
COR068
TKY021
SG14
SG16
12
13
LEX37
14
AHT020
CTLA3
GHR
C9
NPR3
IL7R
BASP1
16
17
18
50
KIAA0073
100
LEX060
GHR
5
54.5
13
HMGCS1
43.5
13
110.6
GHRH
TKY280
GHR
42.8
15
3.1
C9
39.4
15
6.2
BASP1
LEX037
FLJ14054
NPR3
32.5
13
AHT030
COR087
11.8*
32.4
15
15
11.8
COR022
IL7R
36.0
15
9.5
BASP1
17.2
15
25.4*
HMS47
HTG14
14
PDYN
TKY040??
STS-D29077 ?
PRNP
ASIP
16
18
SG01
19
22
AHT078
1.9
4.6
2 130.6
2 132.9
HTG14
BMP2
6.7
2 134.5
HMS47
SG19
AHT031
COR022
AHCY
20
UMNe77
ASIP
32.6
RPN2
LEX002
150
IFNB1
13
ASIP
HTG21
RPN2
SG01
COR055
32.6
2 155.8
35.5
2 158.1
COR084
LEX63
SG04
ADA
42.9
2 164.6
UM022
UM027
17
18
19
23
GNAS1
GNAS1
EDN3
SG19
300
57.1
57.6
IFNB1
IFNA1
MTAP
SPIN
SIGMAR1
SG04
UMNe51
ASB39
LEX063
UM027
9
13 61.6
CDKN2A
22.2
4 86.7
TYRP1
12.8
4 78.1
NUMB
2.7
19
26.9
IFNB1
21.4
4
85.9
IFNA1
21.7
4 86.2
MTAP
22.1
4 86.5
SIGMAR1
SPIN
82.0
SG04
SIGMAR1 34.9
LEX053
IFNB1
MTAP
IFNA1
COR084
SPIN
13
TKY036
COX4P1
AHT032
AHT004
TGFB3
SPTB
TKY036
TKY037
13
AHT04
COR024
14
AHT032
LEX42
LEX74
UM012
50.4
200
FLRT2
14
COR061
LEX074
CALM1
COR087
LEX32
EA2C4
150
15
FLRT2
16.1
16.2
16.3
PI/AAT7
300
NUMB
HIF1A
71.2
59.4
12 78.4
12 68.5
SPTB
62.5
12 71.2
TGFB3
73.9
12 80.7
FLRT2
83.5
12 89.9*
CALM1
88.3
12 94.3
HSPA5
TXN
SERPINA1 92.3
12
XPA
13
COR018
50
100
15
GGTA1
COR080
UCD405
UCD464
16
EPB72
17
18
-
0
ABL1
AHT051
50
XPA
91.2
4
45.0
ABL1
124.6
2
32.1*
HSPA5
119.1
2
35.1
2
35.8
NV043
HSPA5
9
AHT007
UCD405
GGTA1
COR018
EPB72
115.2
2
35.7
TXN
103.8
4
56.8
UCD464
DBH
127.5
2
27.3
PLG
PLG
160.4
17
11.7
IGF2R
159.8
17
11.9
VIP
152.6
10
5.4
PCMT1
149.6
10
7.4
ESR1
151.6
10
4.5
TXN
DBH
UCD464
19
350
COR080
25
COR024
400
2 175.5
0
14
14
LEX032
(SERPINA1)
24
4 41.5
250
SERPINA1
11
-
12
100
COR061
VLDLR
AHT004
TKY037
COX4P1
12
COR025
UM022
0
50
11
19 14.0*
19 20.2
UMNe69
0
16
ADA
HMS47
ALDH1A1
200
88.1
TLE4
73.3
ALDH1A1 66.5
100
ASB39
VLDLR
15
LEX53
UM019
COR016
CDKN2A
TYPR1
FBP1
TLE4
150
200
250
FBP1
14
2 155.8
50
100
IFNA1
AHT039
12
TYRP1
AHCY
0
0
50
11
CNFTR
BMP2
RPN2
17
LEX002
PDYN
PRNP
LEX042
HIF1A
AHT039
150
15
COR016
50
21
100
COR060
COR055
UM019
50
11
12
GNAS1
COR001
FLJ14054
HTG32
IL7R
19.2
CTLA3
EDN3
PRNP
C9
150
ADA
65.0
ASIP
SG16
HTG10
CTLA3
COR068
HMGCS1
0
SG14
SG16
0
0
COR001
TKY285
COR073
KIAA0073
COR073
HTG10
TKY021
SG14
11
LEX60
NV021
121.1
HTG13
100
0
C9
COL9A1
150
7.3
9.8
UM012
MUT
COR050
SGP28
22
X
X
AHT091
15
SGP28
100
13 41.8
GSTA1
DMA
UMNe56
21.1
HMS42
HTG05
0
CD164
15
ELA-DRA
COR050
100
COR029
HTG05
NV005
AHT018
EDN1
UMNe64
UMNe67
LEX052
LEX064
DQA
12.3
6.1
UMPS
RARB
TGFBR2
GLB1
CRTAP
PB1
50
250
EDN1
F13A1
COR039
RARB
LEX059
200
AHT100
AHT037
PDCD6IP
AHT038
LEX56
15
0
TKY279
RHO
COR064
ASB02
SG06
APOB
SG06
1 121.3
B-8
ASB15
0
LEX46
116.8
LCT
SFTPB
SFTPB
TKY011
CAD
POMC
25
EN1
LEX051
COR076
COR077
CSPG2
CRTL1
HEXB
HMGCR
24
IL1B
COR076
MDH1
22
LEX046
IL1RN
50
150
B-8
COR075
CSPG2
LEX078
COR002
HEXB
HMGCR
24
26
85.4
180.3
179.2
151.1
AHT088
SOD2ps
UM010
1.4
RASA1
MGAT1
CANX
SPARC
CAMK4
AHT083
0
LEX78
SLC6A3
PDE6A
ADRB2
SPARC
PDE6A
HEXB
SPARC
HTG03
50
0
36.3
AHT081
GUCY2D
TP53
11
OTC
CRSP2
X
X
AHT063
65.9
46.8
0
29
HLM2
X
RBM3
28
350
29.6
LEX010
IGSF1
GPC3
F9
UM038
RCV1
LEX028
UMNe58
LEX027
OTC
X 109.4
X 81.8
100
27
300
DMD
AHT086
4.5
52.0
ALAS2
MAGE-E1 49.1
TKY038
UCD428
UCD502
UCD502
0.9
2.6*
AHT079
PLP1
LEX10
22
34.2
9.1
X
XY
7
ANT3
ARSC1
CLCN4
CRSP2
50
0
LEX26
PEX7
100
MG61
XIST
UM038
SG31
PGK1
AHT028
LAMP2
AR
GLRA2
ARG1
LEX026
150
COR091
LEX24
100
NV075
100
LEX22
16
ASB01
ARSC1
ALDH2ps
17
COR074
LEX03
13
IGF2
16
15
13
12
11
11
12
13
14
15
16
PAK3
0
21
TKY039
14
F9
118.7
107.5
105.3
106.7
107.1
107.0
0
ARSC1
ANT3
CLCN4
COR074
NARS
UM033
COR056
SG22
PDE6G
25
24
23
22
0
UCD467
2 176.0
450
COR025
0
HNRPU
AHT031
EDN3
LEX018
11
12
DCSR1
ETS2
A-17
0
13
A-17
14
LEX044
KRTAP8
50
COR071
LEX044
TKY275
COR099
EB2E8
A-17
EB2E8
EB2E8
15
DSCR1
COR071
LEX44
SOD1
16
17
26
ETS2
MX1
CRYAA
100
DSCR1
NV070
ASB38
21
SOD1
DSCR1
ETS2
MX1
CRYAA
29.6
32.4
36.7
39.3
41.1
16 90.8
COR017
16 93.0
COR040
16 96.6
16 98.6
17 30.8
11
12
12
0
13
16 89.5
KRTAP8
11
HMS45
14
50
15
100
HMS45
LEX005
16
COR040
ARSA
HMS45
CYP2D
F11
IGF1
LEX005
F11
188.2
8 44.4
MGF1
UCD425
COR017
17
4
AHT082
150
KITLG
13
CA005
LEX05
UCD005
ASB38
UM003
TKY018
TMPO
14
15
27
UM003
50
IGF1
IGF1
12
16
150
CYP2D@
BLG1/2
UCD425
28
88.1
10 100.2
AKR1C3
TMPO
98.3
10
VIM
91.3
UCD425
TIMP3
22
12
100
13
101.8
10
CYP2D@
ARSA
BLG1/2
29.8
39.0
47.5
10
88.0
15
15
86.4
83.1
83.2
COR027
LEX025
COR082
15
150
CTSLL
COR027
VIM
200
LOC91452
10
VIM
TXNL2
LOC91452
COR082
VIAS-H39
AKR1C3
ASB43
16
29
46.5
17.2
130.7
27.2
LEX25
2
7
2
13.6
127.5
23.3*
250
AKR1C3
ASB43
HTG27
HNRPU
242.9
1 179.6
100
HMS18
AKR1C3
5.1
13
3.8*
UCD455
ESR1
1
13
PLG
UMNe78
0
LEX75
HMS18
14
TGFB2
217.1
PLG
13
50
14
AHT033
VIAS-H21
15
50
VHL20
AHT023
15
100
30
AHT023
LEX075
UCD455
(POSTER SUPPORTED BY FUNDING FROM THE DOROTHY RUSSELL HAVEMEYER FOUNDATION)
0
IGF2R
1 187.7
COR038
VIAS-H21
TGFB2
VHL020
11
12
AHT062
12
VIASH39
TXNL2
50
11
TKY112
CTSLL
COR021
ARSA
0
50
14
CYP2D@
TIMP3
17
KITLG
IGF1
100
18
18
0
11
HTG30
COR021
AHT034
ESR1
16
17
31
100
AHT033
TKY274
COR038
VIP
VIAS-H21
PCMT1
AHT034
150
TKY278
TKY105
6