CURRICULUM VITAE
I. GENERAL INFORMATION
Name:
Sarah Perry Thayer, MD, PhD
Associate Director for Clinical Affairs and
Physician-In-Chief, Fred & Pamela Buffett Cancer Center
Chief, Division of Surgical Oncology
Office:
University of Nebraska Medical Center (UNMC), Division of Surgical Oncology,
986345 Nebraska Medical Center, Omaha, NE 68198-6345
E-Mail:
[email protected]
Telephone: 402-559-7298
Fax: 402-559-7900
Education:
1985
1987
1991
1994-1999
BA
MS
MD
PhD
Earlham College, Richmond, IN
Georgetown University, Washington, DC, Physiology and Biophysics
University of Virginia School of Medicine, Charlottesville, VA
Cornell University Graduate School of Medical Sciences, Dept. of
Neuroscience, New York, NY. (Thesis work done in the laboratory of
Dr. Kathleen Scotto, Department of Eukaryotic Transcription, Memorial
Sloan-Kettering Cancer Center, Rockefeller Research Laboratory)
Continuing Education:
2013-2014
Executive Education Program, Managing Health Care Delivery, Harvard
Business School, Boston, MA
Postdoctoral Training:
Internship and Residencies:
1991-1992
General Surgery Internship, Massachusetts General Hospital (MGH), Boston,
MA
General Surgery Junior Resident, MGH, Boston, MA
Surgical Research Fellow, Cornell University/Memorial Sloan-Kettering
Cancer Center, New York, NY
General Surgery Senior Resident, MGH, Boston, MA
1992-1994
1994-1998
1998-2000
Fellowships:
1994-1995
1995-1999
2000-2001
The Varazted H. Kazanjian Research Fellowship, MGH, Boston, MA
Memorial Sloan-Kettering Cancer Center, New York, NY
Chief of Churchill Service, Instructor in Surgery, additional post-doctoral
training position focused on complex surgical oncology procedures, MGH,
Boston, MA
Licensure and Certification:
1991-
Commonwealth of Massachusetts License (No. 203874)
Sarah P. Thayer, M.D., Ph.D.
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1994-1996
2001-2012
2010-2022
2014-
State of New York License (No. 197481)
American Board of Surgery Certification (No. 46560)
American Board of Surgery Recertification (No. 046560)
State of Nebraska License (No. 27762)
Academic Appointments:
2001-2004
2004-2009
2010-2014
20142014-
Instructor in Surgery, Harvard Medical School
Assistant Professor of Surgery, Harvard Medical School
Associate Professor of Surgery, Harvard Medical School
Merle M. Musselman Centennial Professor of Surgery, UNMC
Professor, Eppley Institute for Research in Cancer, UNMC, Joint Appointment
Hospital Appointments:
2000–2001
2001–2003
2003-2009
2008-2014
2009-2014
2014-2016
201420142014-
Chief, Surgical Services, Assistant in Surgery, MGH, Boston, MA
Assistant in Surgery, Surgery Service, MGH, Boston, MA
Assistant Surgeon, Surgery Service, MGH, Boston, MA
Director, Pancreatic Biology Laboratory, MGH, Boston, MA
Associate Visiting Surgeon, Surgery Service, MGH, Boston, MA
Visiting Scientist, MGH, Boston, MA
Active Academic Staff Surgeon, Nebraska Medicine, Omaha, NE
Chief, Division Surgical Oncology, Nebraska Medicine, Omaha, NE
Physician-In-Chief and Associate Director for Clinical Affairs for the Fred &
Pamela Buffett Cancer Center (F&PBCC), Nebraska Medicine, Omaha, NE
Major Administrative Responsibilities:
2000-2001
2008-2014
20142014201420142014201420142014
20152015201520162016-
Organized all weekly teaching conferences, including Surgical Grand Rounds,
Oncology Conference, Gastrointestinal Conference, and Thoracic Conference,
MGH
Director, Pancreatic Biology Laboratory, MGH, Boston, MA
Director, Thayer Research Laboratory, UNMC, Omaha, NE
Chief, Division Surgical Oncology, Nebraska Medicine, Omaha, NE
Physician-In-Chief and Associate Director for Clinical Affairs for the F&PBCC,
Nebraska Medicine, Omaha, NE
Executive Committee for the Cancer Center Project, Nebraska Medicine,
Omaha, NE
Cancer Center Senior Leadership Council, Nebraska Medicine, Omaha, NE
Cancer Center Governance Committee, Nebraska Medicine, Omaha, NE
Chancellor’s Diversity Advisory Steering Committee, Nebraska Medicine,
Omaha, NE
Medical Director, Comprehensive Breast Cancer Service, UNMC, Omaha, NE
Clinical Operations Council, Nebraska Medicine, Omaha, NE
Cancer Clinical Operations Group, Nebraska Medicine, Omaha, NE
Patient Access Oversight Council, UNMC, Omaha, NE
Chair, Women’s Cancer Center Council, UNMC, Omaha, NE
Lead, F&PBCC Electronic Filing Committee, UNMC, Omaha, NE
Sarah P. Thayer, M.D., Ph.D.
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2016-
F&PBCC Strategic Events Committee, UNMC, Omaha, NE
Major Committee Assignments:
UNMC and F&PBCC:
2016201620162016201620162015201520152015201520152014 20142014201420142014201420142014-2015
Chair, Women’s Cancer Center Council
Member, F&PBCC Strategic Events Committee
Member, F&PBCC Utilization Management Committee
Lead, F&PBCC Electronic Filing Committee
Member, F&PBCC Donor Naming & Public Wayfinding/Signage Committee
Member, F&PBCC Senior Clinical & Operations Advisory Committee
Internal Advisory Board (IAB) 2016 Pancreatic SPORE
Internal Advisory Board (IAB) 2016 GI SPORE
Clinical Operations Council
Patient Access Oversight Council
Cancer Clinical Operations Group
Cancer Prevention and Control Program
Cancer Center Governance Committee
Practice Committee
Executive Committee for the Cancer Center Project
Healing Arts Program Committee
Surgical Subject Matter Experts Team
Intensive Care Unit Subject Matter Experts Team
Cancer Center Senior Leadership Council
Chancellor’s Diversity Advisory Steering Committee
Academic Variable Compensation Committee
Massachusetts General Hospital:
2001-2014
2003-2005
2004, 2011
2005-2014
2005-2014
2007-2014
2008-2009
2008-2014
2011-2014
Member, Executive Committee, Women’s Health Coordinating Council
Member, Executive Committee on Research Subcommittee on Review of
Research Proposals, Fund for Medical Discovery Study Section
Member, Physician Nominating Committee of the MGH Physician
Organization (MGPO) Executive Committee
Member, Surgical Research Council
Member, Resident Training and Education Committee, Surgical Research
Council
Associate Faculty, Center for Human Genetic Research, MGH & Harvard
Medical School
Member, Physician Nominating Committee of the MGPO Executive
Committee
Member, Clinical Referral Management Improvement Initiative Steering
Committee
Fellowship Award Committee, MGH Department of Surgery
Sarah P. Thayer, M.D., Ph.D.
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Harvard Medical School:
2004-2008
2005-2009
Member, Committee on Admissions
Faculty Advisor, Oncology Interest Group Research Committee
Affiliated Institutions:
2002-2012
PI, Project 1, NIH GI SPORE Project, “Improved Peri-Operative Staging of
Pancreatic Cancer,” Dana-Farber Cancer Institute (DFCI)
Member and Principal MGH Scientific Contact, DFCI/Harvard Cancer
Center, Gastrointestinal Cancer Program, Pancreatic Program Working
Group
Member, DFCI Gastrointestinal Cancer Center Clinical Research Committee
Director, BioBank Core, NIH Consortium Project, “Genetics and Biology of
Pancreatic Duct Adenocarcinoma” (DFCI/MD Anderson)
2003-2014
2007-2014
2006-2014
Regional/National:
2008-2014
2008-2014
2008-2011
2008-2014
Guidelines Panel, National Comprehensive Cancer Network (NCCN)
Program Committee, Pancreas Club
Committee on Social and Legislative Issues, Society of University Surgeons
Scientific Advisory Board, The Lustgarten Foundation for Pancreatic Cancer
Research
Strategic Planning Committee, American Pancreatic Association (APA)
Scientific Review Board, The Lustgarten Foundation for Pancreatic Cancer
Research
Clinical and Translational Cancer Research Committee, Cancer Prevention &
Research Institute of Texas
Pancreatic Cancer Action Network-AACR Career Development Awards
Scientific Review Committee
NCCN Panel for Pancreatic Adenocarcinoma
2009201220132015
2015International:
2008-
International Cancer Genome Consortium
Community:
2008-2014
Advisor, Students on the Forefront of Science Program, Brooks School
Editorial Boards:
2007-2014
Editorial Board, Pancreatology
Professional Societies:
1998199820002002200220022002-
American Medical Association (AMA)
MGH Surgical Alumni Society
APA
American Association for the Advancement of Science (AAAS)
International Association of Pancreatology (IAP)
New York Academy of Sciences
Society of Laparoendoscopic Surgeons (SLS)
Sarah P. Thayer, M.D., Ph.D.
Page 5
200520062006-2014
200620062007200720092012201420152015-
American College of Surgeons (ACS), Fellow
American Hepato-Pancreato-Biliary Association (AHPBA)
NCI Cancer and Leukemia Group B (CALGB)
Society of University Surgeons
Boston Pancreas Study Group
Boston Surgical Society
Pancreas Club
New England Surgical Society
Society for Surgery of the Alimentary Tract (SSAT)
American Society of Clinical Oncology (ASCO)
Society of Surgical Oncology (SSO)
American Society of Breast Surgeons (ASBS)
Awards and Honors:
1989
1991
1991
1991
2000
2002
2003
2004
2002-2014
20142016
2017
Alpha Omega Alpha, University of Virginia School of Medicine
Sandoz Award in recognition of superior academic achievement and
contribution to health care
Janet M. Glasgow Memorial Award of the American Medical Women’s
Association
Valedictorian, University of Virginia School of Medicine
Resident/Fellow Award for Excellence in Clinical Teaching in Surgery,
Harvard Medical School
Phillip H. Meyers, MD, Annual Research Grant (award) from the Society of
Gastrointestinal Radiologists, for Visionary Research in Medical Imaging
(Acute Mesenteric Ischemia) using Multi-Detector CT and CT Angiography
Hirshberg Award for Best Presentation, Annual Meeting APA, Chicago, IL
Investigator Award for Outstanding Publication (Nature 2003; 425 [Oct. 23]:851856), Santa Cruz Biotechnology
W. Gerald Austen Scholar in Academic Surgery, MGH and Harvard Medical
School
Merle M. Musselman Centennial Professor of Surgery, UNMC
NESS Paper of the Year Award for, “Prognosis of invasive intraductal papillary
mucinous neoplasms depends on histological and precursor epithelial
subtypes”
UNMC Distinguished Scientist/New Investigator Award for 2016. Ceremony
held on 01/17/2017
II. RESEARCH, TEACHING, AND CLINICAL CONTRIBUTIONS
A. Current Research Activities:
The focus of the Thayer laboratory has been to investigate the genes that may contribute to
the initiation, progression and regulation of pancreatic cancer. My early work focused on
the early and late role of a developmental gene, Shh, in pancreatic cancer (Nature 2003). This
work revealed that Shh is upregulated early in pancreatic carcinogenesis and in response to
chronic inflammatory injury. Although Shh plays an important later role in the biology of
pancreatic cancer, it has an equally important early role as an initiator, driving the formation
of mucinous ductal lesions resembling early precursor lesions to cancer. My lab has since
Sarah P. Thayer, M.D., Ph.D.
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focused further on characterizing the cell of origin responsive to Shh and the mechanism
behind pancreatic regeneration in response to inflammatory injury, and how these may
contribute to the formation of pancreatic cancer precursor lesions, and ultimately to cancer.
My group was the first to categorize and classify three distinct forms of metaplastic ductal
lesions formed in the regenerative response to chronic inflammation (PNAS 2007) and their
role in regeneration and cancer. Using a chronic inflammatory injury model in combination
with in vivo lineage tagging, we demonstrated that the beta cell (PNAS 2007) and acinar cell
(Gastroenterology 2007) compartments regenerate by self-renewal. We went on to
demonstrate that these compartments do not transdifferentiate and do not contribute to the
formation of metaplastic ductal lesions, and thus are an unlikely cell of origin for pancreatic
cancer. Most recently, investigation of Shh has called our attention to a novel pancreatic
epithelial compartment which we have termed pancreatic duct glands (PDGs)
(Gastroenterology 2010). This work shows that PDGs are mucinous compartment with a
distinct molecular signature, expressing many developmental genes believed to mark stem
cell compartments. Subsequent work revealed that PDGs are a unipotential epithelial
progenitor stem cell niche (Stem Cell Res 2015) that undergoes a Shh-mediated mucinous
gastrointestinal metaplasia resembling certain features of pancreatic cancer precursor
lesions. Work recently accepted suggests that the PDGs may be the compartment of origin
for pancreatic cystic neoplasm (Gastroenterology).
B. Patents:
1. Method for Inducing Beta Cell Neogenesis from Epithelial Cells
Q&B Ref: 125141.00165
MGH Ref: 3767.02
C. Grants:
Active
Title:
ID Number:
Funding Agency:
Project Period:
Total Dollars:
Role:
Title:
Targeting the Metabolic Basis of Cachexia in Pancreatic Cancer
1R01CA210439-01A1
DHHS/NIH/NCI
2016-2021
$2,270,325
Co-Investigator, PI Pankaj K. Singh, PhD
Pathobiological Implications of Secretory Mucin MUC5AC in Pancreatic
Cancer
ID Number:
Funding Agency:
Project Period:
Total Dollars:
Role:
DHHS/NIH/NCI
2017-2020
$138,540
Co-Investigator, PI Sukhwinder Kaur, PhD
Title:
ID Number:
Funding Agency:
Project Period:
Total Dollars:
Role:
Multimodal contrast agents for preoperative and intraoperative imaging
2017-41
NE DHHS LB506
2016-2017
$50,000
Co-Investigator, PI Aaron M. Mohs, PhD
Sarah P. Thayer, M.D., Ph.D.
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Title:
ID Number:
Funding Agency:
Project Period:
Total Dollars:
Role:
F&PBCC Support Grant
P30CA036727
DHHS/NIH/NCI
2016-2021
$35,672,339
Program Leader GI Cancer Program (GICP)
Title:
Metabolic Regulation of Tumor Progression, Metastasis and
Chemoresistance by SIRT5/ELK3 Signaling in Pancreatic Cancer
ID Number:
Funding Agency:
Project Period:
Total Dollars:
Direct Costs:
Role:
Title:
ID Number:
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Role:
Title:
ID Number:
Funding Agency:
Project Period:
Total Dollars:
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Role:
Title:
DHHS/NIH
2017-2022
$2,883,905
$1,916,215
Co-Investigator, PI Pankaj K. Singh, PhD
CTCs as predictors of primary and metastatic tumor genetics and biology
of PDAC
1R21CA201886-01
DHHS/NIH/NCI
09/01/2015 – 08/31/2017
$413.875.00
$413,875.00
PI
Polymeric Nanomedicines of Hedgehog Inhibitor and miRNA for
Treating Pancreatic Cancer
1R01GM113166-01A1
DHHS/NIH/NIGMS
2015 - 2019
$1,424,348
$237,000
Co-Investigator, PI Ram Mahato, PhD
ID Number:
Funding Agency:
Project Period:
Total Dollars:
Direct Cost:
Role:
PDG Links Stem Cell Niche to Pancreatic Epithelial Renewal, Repair and
Cancer
5R01CA169086-03
DHHS/NIH/NCI
2013 - 2018
$1,363,661
$207,500
PI
Title:
Funding Agency:
LB595 Tobacco Tax Center Research Grant
NE DHHS - LB595
Sarah P. Thayer, M.D., Ph.D.
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Project Period:
Total Dollars:
Direct Cost:
Role:
Pending
Title:
ID Number:
Funding Agency:
Project Period:
Total Dollars:
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Role:
Title:
ID Number:
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Project Period:
Total Dollars:
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Role:
Title:
ID Number:
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Role:
Title:
ID Number:
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Total Dollars:
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Role:
Submitted
Title:
Funding Agency:
Project Period:
Total Dollars:
Direct Cost:
Role:
2015 - 2019
$30,004,831
$1,300,000
Co-Investigator, PI Ken Cowan, MD, PhD
Troika for the Diagnosis/Prognosis of Pancreatic Cancer
Sanguine Diagnostics and Therapeutics, Inc.
2017-2019
$764,000
$507,641
Co-Investigator, PI Sukhwinder Kaur, PhD
Pancreatic Cancer Metastasis
DHHS/NIH
2017-2022
$9,776,795
$6,500,000
Co-Investigator, PI Surinder Batra
Role of PD2/Paf1 in Pancreatic Acinar to Ductal Metaplasia
DHHS/NIH
2017-2022
$450,389
$300,000
Co-Investigator, PI Moorthy Palanimuthu Ponnusam, PhD
Lutetium-177 labeled genetically-engineered theranostics against
pancreatic cancer
1R01CA206215-01
DHHS/NIH/NCI
2016 - 2021
$2,253,715
$1,500,000
Co-Investigator, PI Maneesh Jain, PhD
Isolation and genetic characterization of breast cancer circulating tumor
cells
NIH/NIGMS “Great Plains IDeA CTR”
03/01/2017-02/28/2018
$50,000
$50,000
PI
Sarah P. Thayer, M.D., Ph.D.
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Title:
Funding Agency:
Project Period:
Total Dollars:
Direct Cost:
Role:
Isolation and genetic characterization of circulating tumor cells as
predictive biomarkers in high-risk early stage breast cancer
NIH/NCI
12/01/2017 – 11/30/2019
$413,875
$275,000
PI
Submitted not funded:
Title:
Funding Agency:
Project Period:
Total Dollars:
Direct Cost:
Role:
Variant-specific functions of DPYSL3 in pancreatic cancer. Applications
for Collaborative Pilot Project Grants-NCCS, Years 3-4 of Phase III
DHHS/NIH/NCI
08/17/2015 –
$100,000
$100,000
PI
Completed:
Title:
ID Number:
Funding Agency:
Project Period:
Total Dollars:
Direct Costs:
Role:
UNMC Eppley Cancer Center Support Grant
3P30CA036727-29S1
DHHS/NIH/NCI
2011-2016
$34,613,080
$1,059,259
Program Leader-PI
D. Teaching/Invited Lectures:
2001
04/11/2002
05/09/2002
2002-2014
10/30/2002
11/01/2002
Lecture, “Gall bladder and bile duct cancer,” Chief's Rounds, Department
of Surgery, MGH, Boston, MA
Lecture, “Lymphangioma and lymphatic malformation,” Grand Rounds,
Department of Surgery, MGH/ Harvard Medical School, Boston, MA
Lecture, “Abnormal expression of developmental signaling pathways in
pancreatic cancer: The role of Sonic hedgehog,” Grand Rounds,
Department of Surgery, MGH, Boston, MA
Preceptor, Introduction to Clinical Medicine — MGH Department of
Surgery, Patient-Doctor II Course for second-year Harvard Medical School
medical students, Boston, MA
Lecture, “Abnormal expression of developmental signaling pathways in
pancreatic cancer: The role of Sonic hedgehog,” Melton Laboratory of
Molecular Embryology, Department of Molecular and Cell Biology,
Harvard University, Boston, MA
Lecture, “Abnormal expression of developmental signaling pathways in
pancreatic cancer: The role of Sonic hedgehog,” Gastrointestinal SPORE
Group Series, MGH, Boston, MA
Sarah P. Thayer, M.D., Ph.D.
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09/04/2003
09/30/2003
10/21/2003
11/04/2003
11/18/2003
03/30/2004
04/08/2004
05/16/2004
09/27/2004
11/18/2004
12/2-3/2004
04/20/2005
05/17/2005
06/11/2005
08/11/2005
09/24/2005
10/04/2005
Lecture, “Sonic hedgehog and the genetics of pancreatic cancer,” Halsted
Society, 77th Annual Meeting, Boston, MA
Lecture, “The ICU consult for abdominal pain,” Post-graduate course in
general surgery, Harvard Medical School Department of Continuing
Education (presented by the Department of Surgery, MGH), Boston, MA
Discussant, Surgical Oncology II Session, Surgical Forum Program, 89th
Annual Clinical Congress, ACS, Chicago, IL
Lecture, “Pancreatic cancer: Future challenges for the clinician and
scientist,” Pancreatic Think Tank, DFCI, Boston, MA
Lectures: (1) “Pancreatic cancer: Future challenges for the clinician and
scientist;” (2) “Sonic hedgehog and pancreatic cancer,” DFCI/Harvard
Cancer Center, Gastrointestinal Cancer Program/Pancreatic Program
Working Group, Boston, MA
Invited speaker, “A translational approach to pancreatic cancer therapy,”
session, “New concepts in organ-site research” (Ronald DePinho and
Margaret Tempero, Co-Chairs) 95th Annual Meeting AACR, Orlando, FL
Lecture, “Abdominal catastrophes in the ICU patient,” Grand Rounds,
Department of Surgery, MGH, Boston, MA
Invited speaker, “Sonic hedgehog and pancreatic cancer,” Digestive
Disease Week (DDW), New Orleans, LA
Post-graduate course in general surgery, Harvard Medical School
Department of Continuing Education (presented by the Department of
Surgery, MGH), Boston, MA
Lecture, “Pancreatic cancer: Unmasking the mysteries,” Surgical Grand
Rounds, Division of General Surgery, MGH, Boston, MA
Invited speaker, “Pancreatic cancer in mice and men: The Penn
Workshop,” sponsored by NCI Mouse Model of Human Cancer
Consortium (MMHCC) and University of Pennsylvania, Philadelphia, PA
Invited Speaker, “Developmental pathways and pancreatic cancer,”
session, New Concepts in Organ-Site Research: Toward Effective
Management of Pancreatic Cancer, 96th Annual Meeting AACR, Anaheim,
CA
Co-chair (with Steven Leach), Research Symposium, “PANIn lesions,”
American Gastroenterological Association/DDW, Chicago, IL
Invited speaker, “Developmental genes and pancreatic cancer,” MGH
Surgical Society Reunion, Boston, MA
Lecture, “The role of developmental genes in pancreatic cancer,” Grand
Rounds, Department of Anesthesia and Critical Care, MGH, Boston, MA
Invited speaker, “Hedgehog and pancreatic cancer,” 5th Annual Dartmouth
Conference on Liver, Pancreas, and Biliary Disease, Dartmouth-Hitchcock
Medical Center, Lebanon, NH
Co-chair (with Ed Whang), Oral Session 4: Pancreatic Cancer II, 36th
Annual Meeting, APA, Chicago, IL
Sarah P. Thayer, M.D., Ph.D.
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03/11/2006
(Same meeting)
06/26-27/2006
09/19/2006
10/09/2006
10/15/2006
04/21/2007
05/03/2007
06/06/2007
10/03/2007
10/03/2007
04/13/2008
05/14/2008
05/15/2008
10/03/2008
11/08/2008
Invited speaker, “Targeting developmental signaling pathways,” Basic
Science Update Symposium: Translational Biotherapies in HPB
Malignancy, AHPBA Annual Meeting, Miami Beach, FL
Discussant, “Pilot study of novel mouse model of human pancreas
adenocarcinoma,” Paper Session IV: Basic Science
Invited speaker, “Developmental genes and pancreatic cancer,”
Lustgarten Foundation for Pancreatic Cancer Research, 8th Annual Scientific
Conference, “Pancreatic Cancer: Early Detection and Novel Therapies,”
Chapel Hill, NC
Invited speaker, “Pancreatic cancer,” MGH/ Harvard Medical School
postgraduate course in general surgery, “Advances in Gastrointestinal
Surgery,” Boston, MA
Co-moderator (with Ed Whang), surgical forum session, “Alimentary tract
I: Stomach, hepatobiliary and pancreas,” 92nd Clinical Congress, ACS,
Chicago, IL
Keynote speaker, 1st Boston Walk for Pancreatic Cancer, Lustgarten
Foundation for Pancreatic Cancer Research, Boston, MA
Moderator, Basic Science Session and Biliary II Session, AHPBA Annual
Meeting, Las Vegas, NV
Invited speaker, “The surgical management of early pancreatic cancer
and/or lesions with malignant potential,” MGH Inaugural PancreaticBiliary Day, MGH Digestive Health Care Center, Boston, MA
“The surgical management of pancreatic cancer,” Chief’s Rounds,
Department of Surgery, MGH, Boston, MA
Invited speaker, “What is the cell of origin of pancreatic neoplasia: Acinar,
islet, duct or stem cells?” APA/Lustgarten Foundation Symposium “Stem
Cells, the Pancreas, and Pancreatic Cancer,” following the APA Annual
Meeting, Chicago, IL
Co-moderator (with Steven Leach, MD), session, “Model Organisms,”
APA/Lustgarten Foundation Symposium, “Stem cells, the pancreas, and
pancreatic cancer,” following the APA Annual Meeting, Chicago, IL
Genetics and Biology of Pancreatic Duct Adenocarcinoma – “Core C:
Biobank core,” Pancreatic Ductal Adenocarcinoma (PDAC) P01 Program
Retreat, Annual Meeting AACR, San Diego, CA
“Pancreatic cancer: From bench to bedside,” Friends of the MGH Cancer
Center, Boston, MA
“Cell of origin of pancreatic cancer,” symposium, “Gastrointestinal Cancer
Research at Harvard,” sponsored by DFCI/Harvard Cancer Center
Gastrointestinal Malignancies Program, Harvard Club, Boston, MA
“Pancreatic cancer: Collaborative opportunities” (Representing
DFCI/Partners P01 Project on Pancreatic Adenocarcinoma, BioBank Core)
Scientific Advisory Board meeting, Genomics and Biocomputing Platforms,
International Human Cancer Genome Project, Ontario Institute for Cancer
Research, Toronto, Canada
Moderator of sessions, “Early Events in Disease Development” and
“Animal Models of Chronic Pancreatitis and Pancreatic Cancer,“
Sarah P. Thayer, M.D., Ph.D.
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05/22/2009
11/04/2009
11/07/2009
11/14/2009
03/06/2010
03/21-23/2010
05/10/2010
11/04/2010
05-09/2011
06/14/2011
10/26/2011
11/04/2011
11/08/2012
11/12-15/2012
02/13/2013
04/22/2013
APA/Lustgarten Foundation Symposium, “The Chronic Pancreatitis to
Pancreatic Cancer Continuum,” following the APA Annual Meeting,
Chicago, IL
“Pancreatic cancer: Possible research strategies and solutions,”
Department of Surgery, Medical College of Wisconsin, Milwaukee, WI
“Pancreatic cancer: Enrichment and advances in sample acquisition”
International Cancer Genome Consortium (ICGC) Meeting, Honolulu, HI
“Invasive IPMC vs. PDAC: Are they biologically and genetically distinct?”
Mini-symposium 5 on IPMN, APA & Japan Pancreas Society, Honolulu, HI
“Pancreatic cancer: Approaches to future therapies,” course, “Pancreatic
Cancer: Early Diagnosis and Innovative Treatments,” Washington
University School of Medicine/Siteman Cancer Center, St. Louis, MO
“Potential drugs and targets along the hedgehog signaling cascade in
pancreatic cancer and other solid tumors,” session, “Potential Therapeutic
Targets for Clinical Trials,” 63rd Cancer Symposium, SSO, St. Louis, MO
Invited participant, Third Scientific Workshop of the ICGC, Madrid, Spain
Presentation, “The role of Shh in pancreatic metaplasia and malignancy,”
11th Annual Symposium, “The Biology of Pancreatic Development,
Regeneration and Malignancy,” NIH Center for Molecular Studies in
Digestive and Liver Diseases and the Penn/CHOP Center for Digestive,
Liver and Pancreatic Medicine, Division of Gastroenterology, University of
Pennsylvania, Philadelphia, PA
Moderator of session, “Pancreatic Cancer,” APA Annual Meeting, Chicago,
IL
“Duct cell progenitors,” research symposium, “Pancreatic Stem Cells”
American Gastroenterological Association, DDW, Chicago, IL
“Hedgehog signaling,” Harvard Catalyst Clinical and Translational Science
Center, Harvard Medical School, Boston, MA
“Observation: Which pancreatic cystic lesions can be safely followed?”
Session, “Management of Cystic Lesions of the Pancreas,” 97th Annual
Clinical Congress, ACS, San Francisco, CA
Moderator of session, “Basic and Clinical Pancreatic Cancer,” APA Annual
Meeting, Chicago, IL
Invited speaker, “Pancreatic cancer risks and solutions,” Dr. Oz Show
broadcast, “Your Biggest Cancer Risks: The Biggest Solution,” New York,
NY
Invited participant, 3rd Annual Meeting World Circulating Tumor Cells
(CTC) Summit, Boston, MA
Invited speaker, “The capture, growth and genetic analysis of CTC in
PDAC,” session chair, “Circulating Tumor Cells: Future of Cancer
Management,” Cambridge Healthtech Institute Molecular Medicine TriConference, San Francisco, CA
Invited speaker, “Diagnosis can be achieved by screen cell CTC cytology”
Screen Cell, Paris, France
Sarah P. Thayer, M.D., Ph.D.
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04/24/2013
05/13/2013
07/21-26/2013
10/2-3/2014
10/26-30/2014
11/05/2014
11/07/2014
03/03/2015
07/08/2015
09/11-15/2015
09/13/2015
10/09/2015
03/5/2016
07/13/2016
08/09/2016
08/15/2016
08/15/2016
08/16/2016
10/07/2016
10/24/2016
Invited speaker, “The capture, growth and genetic analysis of CTC in
PDAC,” session, “Latest Insights on Capture, Enumeration and
Characterization,” World CTC, April 24-25, Berlin, Germany
Invited speaker, “Pancreatic duct glands (PDG), an epithelial progenitor
compartment important in regeneration and cancer,” Harvard Pancreas
Group Dinner, Harvard Club, Boston, MA
Invited speaker, “Pancreatic duct glands (PDG): An epithelial progenitor
stem cell compartment important in regeneration and cancer,” Gordon
Research Conference: Pancreatic Diseases 2013, Mount Holyoke College,
South Hadley, MA
“Update in the management of pancreatic cystic neoplasms,” 9th Annual
Fall Midwest Thoracic and GI Oncology Conference, Omaha, NE
Co-moderator, “Necrotizing pancreatitis: The devil is in the details,” ACS
Clinical Congress, San Francisco, CA
Co-presenter, “Biomarkers for early detection,” Early Detection of Sporadic
Pancreatic Cancer Summit Conference, Big Island, HI
Moderator, “Innovation in pancreatic cancer treatment,” APA 45th
Anniversary Meeting, Big Island, HI
Testimony before the Appropriations Committee of the Nebraska
Legislature, Lincoln, NE
UNMC Grand Rounds, Service Introduction by Chiefs, Omaha, NE
Presentation at the 7th Muscat International Oncology and 4th Oman Cancer
Association Conference, Muscat, Oman
Invited Speaker, “Breast cancer is a global disease: Is global screening
appropriate for all?” 7th Muscat International Oncology & 4th Oman Cancer
Association, Muscat, Oman
Invited Speaker, “Operative treatment for pancreatic cancer patients with
metastatic disease,” 10th Annual Fall Midwest Thoracic and GI Oncology
Conference, Omaha, NE
Invited Speaker, Winter Workshop of the Nebraska State Assembly for
Surgical Technologists. College of Public Health, UNMC, Omaha, NE
Invited Speaker, 7th Extraordinary Innovations and Emerging Trends in
Transplantation and Oncology from Nebraska Medicine, Optum Health
Conference. Presentation entitled, “Current Management of Breast Cancer:
A Multidisciplinary Approach,” Century Link Center, Omaha, NE
Invited Speaker, Telehealth Presentation: “Update of the Fred & Pamela
Buffett Cancer Center,” Omaha, NE
Presentation concerning the Gastrointestinal Cancer Program to attendees
at the Senior Leadership Council Retreat, Omaha, NE
Presentation concerning the Strategic Investment Group (SIG) to attendees
at the Senior Leadership Council Retreat, Omaha, NE
Presentation concerning the Women’s Cancer Center for the University of
Nebraska Foundation, Happy Hollow Country Club, Omaha, NE
Presentation at the GI Oncology Conference, Scott Conference Center,
University of Nebraska Omaha, Omaha, NE
Presentation for the Board of Counselor’s Meeting, UNMC, Omaha, NE
Sarah P. Thayer, M.D., Ph.D.
Page 14
11/30/2016
12/13/2016
03/31/2017
Introduction for the Miller Lecture and Dr. Douglas Evans
Breast Education Presentation to the 9 North Nurses at UNMC
Presentation at the 69th Annual Meeting & Scientific Assembly of the
Nebraska Academy of Family Physicians (NAFP), La Vista, NE
Teaching Awards:
2000
Resident and Fellow Award for Excellence in Clinical Teaching in Surgery,
Harvard Medical School
Mentoring/Advising:
2002–2005
2003–2005
2004–2006
2005–2007
2005–2007
2006
2006–2007
2006–2008
2006–2008
2007–2009
2007–2010
2008
HMS
Research Fellow
Research Fellow (T32)
Research Fellow
Research Fellow (T32)
Summer student
HMS
Research Fellow
Research Fellow
Research Fellow
Research Fellow
Summer student
2008–2009
2009
Research Fellow
Summer student
2009–2011
2009–2014
2010-2012
2010–2013
2010
Research Fellow
Research Fellow
Research Fellow
Research Fellow
Summer student
2011
2012
Research Fellow
Summer student
2012–2013
2012
2012
Research Fellow
Research Fellow
Summer student
2012
Summer student
2012
Intern
2013-2014
2013–2014
Intern
Research Fellow
David E. Rosow, MD
Oliver Strobel, MD (Heidelberg University)
Denise Long, MD (Georgetown University)
Elena Rakhlin, MD (Harvard University)
Janivette Alsina, MD, PhD (UMDNJ)
Steven Poon (Tufts University 2008)
Yin Pun (Rex) Hung (2009)
Jennifer LaFemina, MD (UCLA)
Stefan Fritz, MD (Heidelberg University)
Vasiliki Androutsopoulos, MD (Venezuela)
Dirk Bausch, MD (University of Freiburg)
Michael Hendrickson (Brooks School ’09, program
“Students on the Frontiers of Science”)
Avais M. Chatha, MD (University of Lahore)
Brian Bernier (Brooks School ’10, program
“Students on the Frontiers of Science”)
Joo Kyung Park, MD (Seoul, Korea)
Andrew S. Liss, PhD (University of Texas, Austin)
Nakul Valsangkar, MD (New Delhi, India)
Junpei Yamaguchi, MD (Nagoya, Japan)
Cheng Hui Bryan Chang (Brooks School ’11,
program “Students on the Frontiers of Science”)
Birte Kulemann, MD (University of Freiburg)
Cécile Harmange (Brooks School ’12, program
“Students on the Frontiers of Science”)
Jiahua Zhou, MD, PhD (Nanjing, China)
Naoki Ikenaga, MD, PhD (Fukuoka, Japan)
Lorena Ceci, BS (University of Massachusetts
Medical School)
Gabriel DiNatale (undergraduate, Dickinson
College)
Alexandra Sontheimer (medical student, University
of Freiburg)
Curtis Adams (undergraduate, Tufts University)
Akifumi Nakagawa, MD, PhD (Nagoya, Japan)
Sarah P. Thayer, M.D., Ph.D.
Page 15
2013
2013-2014
2013-2014
Intern
Research Fellow
Research Fellow
2014-2015
20142014201420152015201620162016-
PhD
PhD
Post-doc
Post-doc
MD/PhD Candidate
MD/PhD Candidate
MD/PhD Candidate
PhD Candidate
MD/PhD Candidate
III.
Joachim Vaturi (Lycée Français de New York)
James Perkins, MD (Pennsylvania State University)
Yinshi Huang, MD (Shanghai, China) (starting
11/2013)
Sanjib Chowdhury, PhD (UNMC)
Dulce Maroni Veiga, PhD (UNMC)
Pinaki Mondal, PhD (University of Calcutta)
Xiang Liu, PhD (UNMC)
Richard Sleightholm (UNMC)
Beth Clymer (UNMC)
Andrew C. Cannon (UNMC)
Jaime Abrego, (UNMC)
Cassie Liu, (UNMC)
BIBLIOGRAPHY
Original Articles:
Dubois M, Chen J, Thayer SP, Narang P, Kaufman J, Hatendi A. Pharmacokinetics of
alfentanil continuous IV infusion in neurosurgical patients. Anesth Analg 1987; 66:S44.
2.
Thayer SP, Fernandez-del Castillo C, Balcom JH, Warshaw AL. Complete dorsal
pancreatectomy with preservation of the ventral pancreas: a new surgical technique.
Surgery. 2002;131(5):577-80. PMID: 12019413.
3.
Fernandez-del Castillo C, Targarona J, Thayer SP, Rattner DW, Brugge WR, Warshaw
AL. Incidental pancreatic cysts: clinicopathologic characteristics and comparison with
symptomatic patients. Arch Surg. 2003;138(4):427-3; discussion 33-4. doi:
10.1001/archsurg.138.4.427. PMID: 12686529; PMCID: PMC4403874.
4.
Thayer SP, di Magliano MP, Heiser PW, Nielsen CM, Roberts DJ, Lauwers GY, Qi YP,
Gysin S, Fernandez-del Castillo C, Yajnik V, Antoniu B, McMahon M, Warshaw AL,
Hebrok M. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis.
Nature. 2003;425(6960):851-6. doi: 10.1038/nature02009. PMID: 14520413; PMCID:
3688051.
5.
Thayer S. The emerging role of the hedgehog signaling pathway in gastrointestinal
cancers. Clin Adv Hematol Oncol. 2004;2(1):17, 20, 63. PMID: 16163153.
6.
Salvia R, Fernandez-del Castillo C, Bassi C, Thayer SP, Falconi M, Mantovani W,
Pederzoli P, Warshaw AL. Main-duct intraductal papillary mucinous neoplasms of the
pancreas: clinical predictors of malignancy and long-term survival following resection.
Ann Surg. 2004;239(5):678-85; discussion 85-7. PMID: 15082972; PMCID: 1356276.
7.
Warshaw AL, Thayer SP. Pancreaticoduodenectomy. J Gastrointest Surg. 2004;8(6):73341. doi: 10.1016/j.gassur.2004.03.005. PubMed PMID: 15358336; PMCID: 3811050.
8.
Alsfasser G, Antoniu B, Thayer SP, Warshaw AL, Fernandez-del Castillo C. Degradation
and inactivation of plasma tumor necrosis factor-alpha by pancreatic proteases in
experimental acute pancreatitis. Pancreatology: official journal of the International
Association of Pancreatology. 2005;5(1):37-43; discussion doi: 10.1159/000084489. PMID:
15775698; PMCID: PMC3817566.
9.
Ferrone CR, Kattan MW, Tomlinson JS, Thayer SP, Brennan MF, Warshaw AL.
Validation of a postresection pancreatic adenocarcinoma nomogram for disease-specific
1.
Sarah P. Thayer, M.D., Ph.D.
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survival. J Clin Oncol. 2005;23(30):7529-35. doi: 10.1200/JCO.2005.01.8101. PMID:
16234519; PMCID: 3903268.
Rosow DE, Sahani D, Strobel O, Kalva S, Mino-Kenudson M, Holalkere NS, Alsfasser G,
Saini S, Lee SI, Mueller PR, Fernandez-del Castillo C, Warshaw AL, Thayer SP. Imaging
of acute mesenteric ischemia using multidetector CT and CT angiography in a porcine
model. J Gastrointest Surg. 2005;9(9):1262-74; discussion 74-5. Epub 2005/12/08. doi:
10.1016/j.gassur.2005.07.034. PubMed PMID: 16332482; PMCID: PMC3807105.
Rodriguez JR, Soto Germes S, Pandharipande PV, Gazelle GS, Thayer SP, Warshaw AL,
Fernández-del Castillo C. Implications and cost of pancreatic leak following distal
pancreatic resection. Arch Surg 2006; 141(4):361-365; discussion 366. PMID: 16618893;
PMCID; PMC3998722.
Ferrone CR, Finkelstein D, Thayer SP, Muzikansky A, Fernández-del Castillo C,
Warshaw AL. Perioperative CA19-9 levels can predict stage and survival in patients
with resectable pancreatic adenocarcinoma. J Clin Oncol 2006; Jun 20;24(18):2897-2902.
doi: 10.1200/JCO.2005.05.3934. PMID: 16782929.
Alsfasser G, Warshaw AL, Thayer SP, Antoniu B, Laposata M, Lewandrowski KB,
Fernández-del Castillo C. Decreased inflammation and improved survival with
recombinant human activated protein C treatment in experimental acute pancreatitis.
Arch Surg 2006;141(7):670-676; discussion 670-676. doi: 10.1001/archsurg.141.7.670
PMID: 16847238; PMCID: PMC3972126.
Kwak EL, Jankowski J, Thayer SP, Lauwers GY, Brannigan BW, Harris PL, Okimoto RA,
Haserlat SM, Driscoll DR, Ferry D, Muir B, Settleman J, Fuchs CS, Kulke MH, Ryan DP,
Clark JW, Sgroi DC, Haber DA, Bell DW. Epidermal growth factor receptor kinase
domain mutations in esophageal and pancreatic adenocarcinomas. Clin Cancer Res
2006;12(14 Pt 1):4283-4287. doi: 10.1158/1078-0432.CCR-06-0189. PMID: 16857803;
PMID: 16857803.
Mao J, Ligon KL, Rakhlin EY, Thayer SP, Bronson RT, Rowitch D, McMahon AP. A
novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog
pathway. Cancer Res 2006; 66(20):10171-10178. doi: 10.1158/0008-5472.CAN-06-0657.
PMID: 17047082; PMCID: PMC3806052.
Strobel O, Dor Y, Stirman A, Trainor A, Fernández-del Castillo C, Warshaw AL, Thayer
SP. β cell transdifferentiation does not contribute to preneoplastic/metaplastic ductal
lesions of the pancreas by genetic lineage tracing in vivo. PNAS 2007; 104:4419-4424. doi:
10.1073/pnas.0605248104 PMID: 1736053; PMCID: PMC1815470.
Vagefi PA, Razo O, Deshpande V, McGrath DJ, Lauwers GY, Thayer SP, Warshaw AL,
Fernández-del Castillo C. Evolving patterns in the detection and outcomes of pancreatic
neuroendocrine neoplasms. Arch Surg 2007; 142:347-354. doi:
10.1001/archsurg.142.4.347. PMID: 17438169; PMCID: PMC3979851.
Crippa S, Bassi C, Warshaw AL, Falconi M, Partelli S, Thayer SP, Pederzoli P,
Fernández-del Castillo C. Middle pancreatectomy: Indications, short- and long-term
operative outcomes. Ann Surg 2007; 246(1):69-76. doi:
10.1097/01.sla.0000262790.51512.57. PMID: 17592293; PMCID: PMC1899210.
Rodriguez JR, Salvia R, Crippa S, Warshaw AL, Bassi C, Falconi M, Thayer SP, Lauwers
GY, Capelli P, Mino-Kenudson M, McGrath D, Pederzoli P, Fernández-del Castillo C.
Branch-duct intraductal papillary mucinous neoplasms: observations in 145 resected
Sarah P. Thayer, M.D., Ph.D.
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patients. Gastroenterology 2007; 133:72-79. doi: 10.1053/j.gastro.2007.05.010. PMID:
17631133; PMCID: PMC3807096.
Rodriguez JR, Madanat MG, Healy BC, Thayer SP, Warshaw AL, Fernández-del Castillo
C. Distal pancreatectomy with splenic preservation revisited. Surgery 2007; 141:619-625.
doi: 10.1016/j.surg.2006.09.020 PMID: 17462461; PMCID: PMC3807103.
Strobel O, Dor Y, Alsina J, Stirman A, Lauwers G, Trainor A, Fernández-del Castillo C,
Warshaw AL, Thayer SP. In vivo lineage tracing defines the role of acinar-to-ductal
transdifferentiation in inflammatory ductal metaplasia. Gastroenterol 2007; 133:1999-2009.
doi: 10.1053/j.gastro.2007.09.009. PMID: 18054571; PMCID: PMC2254582.
Nikfarjam M, Warshaw AL, Axelrod L, Deshpande V, Thayer SP, Ferrone CR,
Fernández-del Castillo C. Improved contemporary surgical management of insulinomas:
a 25-year experience at the Massachusetts General Hospital. Ann Surg 2008; 247(1):165172. doi: 10.1097/SLA.0b013e31815792ed PMID: 18156937; PMCID: PMC3806046.
Rodriguez JR, Razo AO, Targarona J, Thayer SP, Rattner DW, Warshaw AL, Fernandezdel Castillo C. Debridement and closed packing for sterile or infected necrotizing
pancreatitis: insights into indications and outcomes in 167 patients. Ann Surg.
2008;247(2):294-9. Epub 2008/01/25. doi: 10.1097/SLA.0b013e31815b6976. PMID:
18216536; PMCID: PMC3806106.
Crippa S, Salvia R, Warshaw AL, Dominguez I, Bassi C, Falconi M, Thayer SP, Zamboni
G, Lauwers GY, Mino-Kenudson M, Capelli P, Pederzoli P, Castillo CF. Mucinous cystic
neoplasm of the pancreas is not an aggressive entity: lessons from 163 resected patients.
Ann Surg. 2008;247(4):571-9. doi: 10.1097/SLA.0b013e31811f4449. PMID: 18362619;
PMCID: 3806104.
Veillette G, Dominguez I, Ferrone C, Thayer SP, McGrath D, Warshaw AL, Fernandezdel Castillo C. Implications and management of pancreatic fistulas following
pancreaticoduodenectomy: the Massachusetts General Hospital experience. Arch Surg.
2008;143(5):476-81. Epub 2008/05/21. doi: 10.1001/archsurg.143.5.476. PMID: 18490557;
PMCID: PMC3806102.
Dominguez I, Crippa S, Thayer SP, Hung YP, Ferrone CR, Warshaw AL, Fernandez-Del
Castillo C. Preoperative platelet count and survival prognosis in resected pancreatic
ductal adenocarcinoma. World J Surg. 2008;32(6):1051-6. doi: 10.1007/s00268-007-9423-6.
PMID: 18224462; PMCID: 3806089.
Crippa S, Dominguez I, Rodriguez JR, Razo O, Thayer SP, Ryan DP, Warshaw AL,
Fernandez-del Castillo C. Quality of life in pancreatic cancer: analysis by stage and
treatment. J Gastrointest Surg. 2008;12(5):783-93; discussion 93-4. doi: 10.1007/s11605-0070391-9. PMID: 18317851; PMCID: 3806099.
Guimaraes AR, Rakhlin E, Weissleder R, Thayer SP. Magnetic resonance imaging
monitors physiological changes with antihedgehog therapy in pancreatic
adenocarcinoma xenograft model. Pancreas. 2008;37(4):440-4. doi:
10.1097/MPA.0b013e31817c5113. PMID: 18953259; PMCID: 3806135.
Ferrone CR, Warshaw AL, Rattner DW, Berger D, Zheng H, Rawal B, Rodriguez R,
Thayer SP, Fernandez-del Castillo C. Pancreatic fistula rates after 462 distal
pancreatectomies: staplers do not decrease fistula rates. J Gastrointest Surg.
2008;12(10):1691-7; discussion 7-8. doi: 10.1007/s11605-008-0636-2. PMID: 18704597;
PMCID: 3806097.
Sarah P. Thayer, M.D., Ph.D.
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34.
35.
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37.
38.
39.
40.
Fritz S, Fernandez-del Castillo C, Mino-Kenudson M, Crippa S, Deshpande V, Lauwers
GY, Warshaw AL, Thayer SP, Iafrate AJ. Global genomic analysis of intraductal
papillary mucinous neoplasms of the pancreas reveals significant molecular differences
compared to ductal adenocarcinoma. Ann Surg. 2009;249(3):440-7. doi:
10.1097/SLA.0b013e31819a6e16. PMID: 19247032; PMCID: 3957431.
Fritz S, Warshaw AL, Thayer SP. Management of mucin-producing cystic neoplasms of
the pancreas. Oncologist. 2009;14(2):125-36. doi: 10.1634/theoncologist.2008-0200. PMID:
19211618; PMCID: 3806054.
LaFemina J, Roberts PA, Hung YP, Gusella JF, Sahani D, Fernandez-del Castillo C,
Warshaw AL, Thayer SP. Identification of a novel kindred with familial pancreatitis and
pancreatic cancer. Pancreatology : official journal of the International Association of
Pancreatology. 2009;9(3):273-9. doi: 10.1159/000201553. PMID: 19407482; PMCID:
3713708.
Bausch D, Mino-Kenudson M, Fernandez-Del Castillo C, Warshaw AL, Kelly KA,
Thayer SP. Plectin-1 is a biomarker of malignant pancreatic intraductal papillary
mucinous neoplasms. J Gastrointest Surg. 2009;13(11):1948-54; discussion 54. doi:
10.1007/s11605-009-1001-9. PMID: 19760374; PMCID: 3806105.
Ferrone CR, Correa-Gallego C, Warshaw AL, Brugge WR, Forcione DG, Thayer SP,
Fernandez-del Castillo C. Current trends in pancreatic cystic neoplasms. Arch Surg.
2009;144(5):448-54. doi: 10.1001/archsurg.2009.36. PMID: 19451487; PMCID: 3806091.
Strobel O, Rosow DE, Rakhlin EY, Lauwers GY, Trainor AG, Alsina J, Fernandez-Del
Castillo C, Warshaw AL, Thayer SP. Pancreatic duct glands are distinct ductal
compartments that react to chronic injury and mediate Shh-induced metaplasia.
Gastroenterology. 2010;138(3):1166-77. doi: 10.1053/j.gastro.2009.12.005. PMID: 20026066;
PMCID: 3806111.
Fritz S, Fernandez-del Castillo C, Iafrate AJ, Mino-Kenudson M, Neyhard N, LaFemina
J, Stirman A, Warshaw AL, Thayer SP. Novel xenograft and cell line derived from an
invasive intraductal papillary mucinous neoplasm of the pancreas give new insights into
molecular mechanisms. Pancreas. 2010;39(3):308-14. doi:
10.1097/MPA.0b013e3181bd5c10. PMID: 19924021; PMCID: 3086384.
Rovira M, Scott SG, Liss AS, Jensen J, Thayer SP, Leach SD. Isolation and
characterization of centroacinar/terminal ductal progenitor cells in adult mouse
pancreas. Proc Natl Acad Sci U S A. 2010;107(1):75-80. doi: 10.1073/pnas.0912589107.
PMID: 20018761; PMCID: 2806716.
Iyer VR, Hahn PF, Blaszkowsky LS, Thayer SP, Halpern EF, Harisinghani MG. Added
value of selected images embedded into radiology reports to referring clinicians. Journal
of the American College of Radiology : JACR. 2010;7(3):205-10. doi:
10.1016/j.jacr.2009.10.014. PMID: 20193926; PMCID: 3086392.
Crippa S, Fernandez-Del Castillo C, Salvia R, Finkelstein D, Bassi C, Dominguez I,
Muzikansky A, Thayer SP, Falconi M, Mino-Kenudson M, Capelli P, Lauwers GY,
Partelli S, Pederzoli P, Warshaw AL. Mucin-producing neoplasms of the pancreas: an
analysis of distinguishing clinical and epidemiologic characteristics. Clin Gastroenterol
Hepatol. 2010;8(2):213-9. doi: 10.1016/j.cgh.2009.10.001. PMID: 19835989; PMCID:
3135334.
Konstantinidis IT, Deshpande V, Zheng H, Wargo JA, Fernandez-del Castillo C, Thayer
SP, Androutsopoulos V, Lauwers GY, Warshaw AL, Ferrone CR. Does the mechanism
Sarah P. Thayer, M.D., Ph.D.
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of lymph node invasion affect survival in patients with pancreatic ductal
adenocarcinoma? J Gastrointest Surg. 2010;14(2):261-7. doi: 10.1007/s11605-009-1096-z.
PMID: 19937477; PMCID: 3135335.
Partelli S, Fernandez-Del Castillo C, Bassi C, Mantovani W, Thayer SP, Crippa S,
Ferrone CR, Falconi M, Pederzoli P, Warshaw AL, Salvia R. Invasive intraductal
papillary mucinous carcinomas of the pancreas: predictors of survival and the role of
lymph node ratio. Ann Surg. 2010;251(3):477-82. doi: 10.1097/SLA.0b013e3181cf9155.
PMID: 20142730; PMCID: 3135381.
International Cancer Genome Consortium (collective authorship, Hudson TJ et al.,
including Thayer SP). International network of cancer genome projects. Nature.
2010;464(7291):993-8. doi: 10.1038/nature08987. PMID: 20393554; PMCID: 2902243.
Correa-Gallego C, Ferrone CR, Thayer SP, Wargo JA, Warshaw AL, Fernandez-Del
Castillo C. Incidental pancreatic cysts: do we really know what we are watching?
Pancreatology : official journal of the International Association of Pancreatology. 2010;10(23):144-50. doi: 10.1159/000243733. PMID: 20484954; PMCID: 3214832.
Tempero MA, Arnoletti JP, Behrman S, Ben-Josef E, Benson AB, 3rd, Berlin JD, Cameron
JL, Casper ES, Cohen SJ, Duff M, Ellenhorn JD, Hawkins WG, Hoffman JP, Kuvshinoff
BW, 2nd, Malafa MP, Muscarella P, 2nd, Nakakura EK, Sasson AR, Thayer SP, Tyler DS,
Warren RS, Whiting S, Willett C, Wolff RA, Adenocarcinoma NP. Pancreatic
adenocarcinoma. J Natl Compr Canc Netw. 2010;8(9):972-1017. PMID: 20876541; PMCID:
3135380.
Konstantinidis IT, Dursun A, Zheng H, Wargo JA, Thayer SP, Fernandez-del Castillo C,
Warshaw AL, Ferrone CR. Metastatic tumors in the pancreas in the modern era. J Am
Coll Surg. 2010;211(6):749-53. doi: 10.1016/j.jamcollsurg.2010.08.017. PMID: 21109158;
PMCID: 3135384.
Bausch D, Thomas S, Mino-Kenudson M, Fernández-del Castillo C, Bauer TW, Williams
M, Warshaw AL, Thayer SP, Kelly KA. Plectin-1 as a novel biomarker for pancreatic
cancer. Clin Cancer Res 2011 Jan 15; 17(2):302-309. Epub 2010 Nov 23. doi: 10.1158/10780432.CCR-10-0999. PMID: 21098698; PMCID: PMC3044444.
Bausch D, Pausch T, Krauss T, Hopt UT, Fernandez-del-Castillo C, Warshaw AL, Thayer
SP, Keck T. Neutrophil granulocyte derived MMP-9 is a VEGF independent functional
component of the angiogenic switch in pancreatic ductal adenocarcinoma. Angiogenesis.
2011;14(3):235-43. doi: 10.1007/s10456-011-9207-3. PMID: 21442180; PMCID: 3688040.
Haynes AB, Deshpande V, Ingkakul T, Vagefi PA, Szymonifka J, Thayer SP, Ferrone CR,
Wargo JA, Warshaw AL, Fernandez-del Castillo C. Implications of incidentally
discovered, nonfunctioning pancreatic endocrine tumors: short-term and long-term
patient outcomes. Arch Surg. 2011;146(5):534-8. doi: 10.1001/archsurg.2011.102. PMID:
21576607; PMCID: 3688044.
Mino-Kenudson M, Fernandez-del Castillo C, Baba Y, Valsangkar NP, Liss AS, Hsu M,
Correa-Gallego C, Ingkakul T, Perez Johnston R, Turner BG, Androutsopoulos V,
Deshpande V, McGrath D, Sahani DV, Brugge WR, Ogino S, Pitman MB, Warshaw AL,
Thayer SP. Prognosis of invasive intraductal papillary mucinous neoplasm depends on
histological and precursor epithelial subtypes. Gut. 2011;60(12):1712-20. doi:
10.1136/gut.2010.232272. PMID: 21508421; PMCID: 3806085.
Genevay M, Mino-Kenudson M, Yaeger K, Konstantinidis IT, Ferrone CR, Thayer S,
Castillo CF, Sahani D, Bounds B, Forcione D, Brugge WR, Pitman MB. Cytology adds
Sarah P. Thayer, M.D., Ph.D.
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53.
54.
55.
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value to imaging studies for risk assessment of malignancy in pancreatic mucinous
cysts. Ann Surg. 2011;254(6):977-83. doi: 10.1097/SLA.0b013e3182383118. PMID:
22041510; PMCID: 3817564.
Ying H, Elpek KG, Vinjamoori A, Zimmerman SM, Chu GC, Yan H, Fletcher-Sananikone
E, Zhang H, Liu Y, Wang W, Ren X, Zheng H, Kimmelman AC, Paik JH, Lim C, Perry
SR, Jiang S, Malinn B, Protopopov A, Colla S, Xiao Y, Hezel AF, Bardeesy N, Turley SJ,
Wang YA, Chin L, Thayer SP, DePinho RA. PTEN is a major tumor suppressor in
pancreatic ductal adenocarcinoma and regulates an NF-kappaB-cytokine network.
Cancer Discov. 2011;1(2):158-69. doi: 10.1158/2159-8290.CD-11-0031. PMID: 21984975;
PMCID: 3186945.
Tempero MA, Arnoletti JP, Behrman SW, Ben-Josef E, Benson AB, 3rd, Casper ES, Cohen
SJ, Czito B, Ellenhorn JD, Hawkins WG, Herman J, Hoffman JP, Ko A, Komanduri S,
Koong A, Ma WW, Malafa MP, Merchant NB, Mulvihill SJ, Muscarella P, 2nd, Nakakura
EK, Obando J, Pitman MB, Sasson AR, Tally A, Thayer SP, Whiting S, Wolff RA, Wolpin
BM, Freedman-Cass DA, Shead DA, National Comprehensive Cancer N. Pancreatic
Adenocarcinoma, version 2.2012: featured updates to the NCCN Guidelines. J Natl
Compr Canc Netw. 2012;10(6):703-13. PMID: 22679115; PMCID: 3807091.
Scherber C, Aranyosi AJ, Kulemann B, Thayer SP, Toner M, Iliopoulos O, Irimia D.
Epithelial cell guidance by self-generated EGF gradients. Integr Biol (Camb).
2012;4(3):259-69. doi: 10.1039/c2ib00106c. PMID: 22314635; PMCID: 3440622.
Nehra D, Oyarvide VM, Mino-Kenudson M, Thayer SP, Ferrone CR, Wargo JA,
Muzikansky A, Finkelstein D, Warshaw AL, Castillo CF. Intraductal papillary mucinous
neoplasms: does a family history of pancreatic cancer matter? Pancreatology : official
journal of the International Association of Pancreatology. 2012;12(4):358-63. doi:
10.1016/j.pan.2012.05.011. PMID: 22898638; PMCID: 3806100.
Valsangkar NP, Morales-Oyarvide V, Thayer SP, Ferrone CR, Wargo JA, Warshaw AL,
Fernandez-del Castillo C. 851 resected cystic tumors of the pancreas: a 33-year
experience at the Massachusetts General Hospital. Surgery. 2012;152(3 Suppl 1):S4-12.
doi: 10.1016/j.surg.2012.05.033. PMID: 22770958; PMCID: 3806101.
Cogdill AP, Frederick DT, Cooper ZA, Garber HR, Ferrone CR, Fiedler A, Rosenberg L,
Thayer SP, Warshaw AL, Wargo JA. Targeting the MAGE A3 antigen in pancreatic
cancer. Surgery. 2012;152(3 Suppl 1):S13-8. doi: 10.1016/j.surg.2012.05.031. PMID:
22770803; PMCID: 3806055.
Ferrone CR, Pieretti-Vanmarcke R, Bloom JP, Zheng H, Szymonifka J, Wargo JA, Thayer
SP, Lauwers GY, Deshpande V, Mino-Kenudson M, Fernandez-del Castillo C, Lillemoe
KD, Warshaw AL. Pancreatic ductal adenocarcinoma: long-term survival does not equal
cure. Surgery. 2012;152(3 Suppl 1):S43-9. doi: 10.1016/j.surg.2012.05.020. PMID:
22763261; PMCID: 3806092.
Fernandez-del Castillo C, Morales-Oyarvide V, McGrath D, Wargo JA, Ferrone CR,
Thayer SP, Lillemoe KD, Warshaw AL. Evolution of the Whipple procedure at the
Massachusetts General Hospital. Surgery. 2012;152(3 Suppl 1):S56-63. doi:
10.1016/j.surg.2012.05.022. PMID: 22770961; PMCID: 3806095.
Rosow DE, Liss AS, Strobel O, Fritz S, Bausch D, Valsangkar NP, Alsina J, Kulemann B,
Park JK, Yamaguchi J, LaFemina J, Thayer SP. Sonic Hedgehog in pancreatic cancer:
from bench to bedside, then back to the bench. Surgery. 2012;152(3 Suppl 1):S19-32. doi:
10.1016/j.surg.2012.05.030. PMID: 22770959; PMCID: 3806061.
Sarah P. Thayer, M.D., Ph.D.
Page 21
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Valsangkar NP, Bush DM, Michaelson JS, Ferrone CR, Wargo JA, Lillemoe KD,
Fernandez-del Castillo C, Warshaw AL, Thayer SP. N0/N1, PNL, or LNR? The effect of
lymph node number on accurate survival prediction in pancreatic ductal
adenocarcinoma. J Gastrointest Surg. 2013;17(2):257-66. doi: 10.1007/s11605-012-1974-7.
PMID: 23229885; PMCID: 3806050.
Faris JE, Blaszkowsky LS, McDermott S, Guimaraes AR, Szymonifka J, Huynh MA,
Ferrone CR, Wargo JA, Allen JN, Dias LE, Kwak EL, Lillemoe KD, Thayer SP, Murphy
JE, Zhu AX, Sahani DV, Wo JY, Clark JW, Fernandez-del Castillo C, Ryan DP, Hong TS.
FOLFIRINOX in locally advanced pancreatic cancer: the Massachusetts General Hospital
Cancer Center experience. Oncologist. 2013;18(5):543-8. doi: 10.1634/theoncologist.20120435. PMID: 23657686; PMCID: 3662845.
Sahora K, Mino-Kenudson M, Brugge W, Thayer SP, Ferrone CR, Sahani D, Pitman MB,
Warshaw AL, Lillemoe KD, Fernandez-del Castillo CF. Branch duct intraductal
papillary mucinous neoplasms: does cyst size change the tip of the scale? A critical
analysis of the revised international consensus guidelines in a large single-institutional
series. Ann Surg. 2013;258(3):466-75. doi: 10.1097/SLA.0b013e3182a18f48. PMID:
24022439.
Cai S, Hong TS, Goldberg SI, Fernandez-del Castillo C, Thayer SP, Ferrone CR, Ryan
DP, Blaszkowsky LS, Kwak EL, Willett CG, Lillemoe KD, Warshaw AL, Wo JY. Updated
long-term outcomes and prognostic factors for patients with unresectable locally
advanced pancreatic cancer treated with intraoperative radiotherapy at the
Massachusetts General Hospital, 1978 to 2010. Cancer. 2013;119(23):4196-204. doi:
10.1002/cncr.28329. PMID: 24006012.
Fong ZV, Ferrone CR, Thayer SP, Wargo JA, Sahora K, Seefeld KJ, Warshaw AL,
Lillemoe KD, Hutter MM, Fernandez-Del Castillo C. Understanding hospital
readmissions after pancreaticoduodenectomy: can we prevent them?: a 10-year
contemporary experience with 1,173 patients at the Massachusetts General Hospital. J
Gastrointest Surg. 2014;18(1):137-44; discussion 44-5. doi: 10.1007/s11605-013-2336-9.
PMID: 24002770.
Fernandez-del Castillo CF, Thayer SP, Ferrone CR, Wargo J. Surgery for small and
asymptomatic branch-duct IPMNs. Ann Surg. 2014;259(3):e47. doi:
10.1097/SLA.0000000000000270. PMID: 24096750.
McDermott S, Thayer SP, Fernandez-Del Castillo C, Mino-Kenudson M, Weissleder R,
Harisinghani MG. Accurate prediction of nodal status in preoperative patients with
pancreatic ductal adenocarcinoma using next-gen nanoparticle. Transl Oncol.
2013;6(6):670-5. PMID: 24466369; PMCID: 3890701.
Hedgire SS, Mino-Kenudson M, Elmi A, Thayer S, Fernandez-del Castillo C,
Harisinghani MG. Enhanced primary tumor delineation in pancreatic adenocarcinoma
using ultrasmall super paramagnetic iron oxide nanoparticle-ferumoxytol: an initial
experience with histopathologic correlation. Int J Nanomed. 2014;9:1891-6. doi:
10.2147/IJN.S59788. PMID: 24790431; PMCID: 4000182.
Lee GC, Fong ZV, Ferrone CR, Thayer SP, Warshaw AL, Lillemoe KD, Fernandez-Del
Castillo C. High Performing Whipple Patients: Factors Associated with Short Length of
Stay after Open Pancreaticoduodenectomy. J Gastrointest Surg. 2014. doi:
10.1007/s11605-014-2604-3. PMID: 25091843.
Sarah P. Thayer, M.D., Ph.D.
Page 22
69.
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71.
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73.
74.
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Marchegiani G, Mino-Kenudson M, Sahora K, Morales-Oyarvide V, Thayer S, Ferrone
C, Warshaw AL, Lillemoe KD, Fernandez-Del Castillo C. IPMN Involving the Main
Pancreatic Duct: Biology, Epidemiology, and Long-Term Outcomes Following
Resection. Ann Surg. 2014. doi: 10.1097/SLA.0000000000000813. PMID: 24979607.
Sahora K, Morales-Oyarvide V, Thayer SP, Ferrone CR, Warshaw AL, Lillemoe KD,
Fernandez-Del Castillo C. The effect of antecolic versus retrocolic reconstruction on
delayed gastric emptying after classic non-pylorus-preserving
pancreaticoduodenectomy. Am J Surg. 2014. doi: 10.1016/j.amjsurg.2014.04.015. PMID:
25124295.
Sahora K, Castillo CF, Dong F, Marchegiani G, Thayer SP, Ferrone CR, Sahani DV,
Brugge WR, Warshaw AL, Lillemoe KD, Mino-Kenudson M. Not all mixed-type
intraductal papillary mucinous neoplasms behave like main-duct lesions: Implications
of minimal involvement of the main pancreatic duct. Surgery. 2014;156(3):611-21. doi:
10.1016/j.surg.2014.04.023. PMID: 25081232.
Tempero MA, Malafa MP, Behrman SW, Benson AB, 3rd, Casper ES, Chiorean EG,
Chung V, Cohen SJ, Czito B, Engebretson A, Feng M, Hawkins WG, Herman J, Hoffman
JP, Ko A, Komanduri S, Koong A, Lowy AM, Ma WW, Merchant NB, Mulvihill SJ,
Muscarella P, 2nd, Nakakura EK, Obando J, Pitman MB, Reddy S, Sasson AR, Thayer
SP, Weekes CD, Wolff RA, Wolpin BM, Burns JL, Freedman-Cass DA. Pancreatic
adenocarcinoma, version 2.2014: featured updates to the NCCN guidelines. J Natl Compr
Canc Netw. 2014;12(8):1083-93. PMID: 25099441.
Naraghi L, Peev MP, Esteve R, Chang Y, Berger DL, Thayer SP, Rattner DW, Lillemoe
KD, Kaafarani H, Yeh DD, de Moya MA, Fagenholz PJ, Velmahos GS, King DR. The
influence of anesthesia on heart rate complexity during elective and urgent surgery in
128 patients. J Crit Care. 2015;30(1):145-9. doi: 10.1016/j.jcrc.2014.08.008. PMID: 25239820.
Valsangkar NP, Ingkakul T, Correa-Gallego C, Mino-Kenudson M, Masia R, Lillemoe
KD, Castillo CF, Warshaw AL, Liss AS, Thayer SP. Survival in ampullary cancer:
Potential role of different KRAS mutations. Surgery. 2015;157(2):260-8. doi:
10.1016/j.surg.2014.08.092. PMID: 25616942.
Kulemann B, Pitman MB, Liss AS, Valsangkar N, Fernandez-Del Castillo C, Lillemoe
KD, Hoeppner J, Mino-Kenudson M, Warshaw AL, Thayer SP. Circulating tumor cells
found in patients with localized and advanced pancreatic cancer. Pancreas.
2015;44(4):547-50. doi: 10.1097/MPA.0000000000000324. PMID: 25822154.
Herman JM, Hoffman JP, Thayer SP, Wolff RA. Management of the Primary Tumor and
Limited Metastases in Patients With Metastatic Pancreatic Cancer. J Natl Compr Canc
Netw. 2015;13(5):e29-36. Epub 2015/07/15. PMID: 26158133.
Yamaguchi J, Liss AS, Sontheimer A, Mino-Kenudson M, Castillo CF, Warshaw AL,
Thayer SP. Pancreatic duct glands (PDGs) are a progenitor compartment responsible for
pancreatic ductal epithelial repair. Stem cell research. 2015;15(1):190-202. Epub
2015/06/24. doi: 10.1016/j.scr.2015.05.006. PMID: 26100232.
Chari ST, Kelly K, Hollingsworth MA, Thayer SP, Ahlquist DA, Andersen DK, Batra SK,
Brentnall TA, Canto M, Cleeter DF, Firpo MA, Gambhir SS, Go VL, Hines OJ, Kenner BJ,
Klimstra DS, Lerch MM, Levy MJ, Maitra A, Mulvihill SJ, Petersen GM, Rhim AD,
Simeone DM, Srivastava S, Tanaka M, Vinik AI, Wong D. Early detection of sporadic
pancreatic cancer: summative review. Pancreas. 2015;44(5):693-712. Epub 2015/05/02.
doi: 10.1097/mpa.0000000000000368. PMID: 25931254; PMCID: PMC4467589.
Sarah P. Thayer, M.D., Ph.D.
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Cauley CE, Pitman MB, Zhou J, Perkins J, Kuleman B, Liss AS, Fernandez-Del Castillo C,
Warshaw AL, Lillemoe KD, Thayer SP. Circulating Epithelial Cells in Patients with
Pancreatic Lesions: Clinical and Pathologic Findings. J Am Coll Surg. 2015;221(3):699-707.
Epub 2015/07/26. doi: 10.1016/j.jamcollsurg.2015.05.014. PMID: 26209458; PMCID:
Pmc4546900.
Huang Y, Nahar S, Nakagawa A, Fernandez-Barrena MG, Mertz JA, Bryant BM, Adams
CE, Mino-Kenudson M, Von Alt KN, Chang K, Conery AR, Hatton C, Sims RJ, 3rd,
Fernandez-Zapico ME, Wang X, Lillemoe KD, Fernandez-Del Castillo C, Warshaw AL,
Thayer SP, Liss AS. Regulation of GLI Underlies a Role for BET Bromodomains in
Pancreatic Cancer Growth and the Tumor Microenvironment. Clin Cancer Res. 2016 May
11. Epub ahead of print. doi: 10.1158/1078-0432.CCR-15-2068. PMID: 27169995.
Sahora K, Morales-Oyarvide V, Thayer SP, Ferrone CR, Warshaw AL, Lillemoe KD,
Fernandez-Del Castillo C. The effect of antecolic versus retrocolic reconstruction on
delayed gastric emptying after classic non-pylorus-preserving
pancreaticoduodenectomy. Am J Surg. 2014. doi: 10.1016/j.amjsurg.2014.04.015. PMID:
25124295.
Yamaguchi J, Mino-Kenudson M, Liss AS, Chowdhury S, Wang, TC, Fernandez-del
Castillo C, Lillemoe, KD, Warshaw AL, Thayer SP. Loss of trefoil factor 2 from
pancreatic duct glands accelerates formation of intraductal papillary mucinous
neoplasms. Gastroenterology. 2016. Dec;151(6):1232-1244.e10. doi:
10.1053/j.gastro.2016.07.045. PubMed PMID: 27523981. Epub 2016 Aug 12.
Conner A, Denroche R, Jang GH, Timms L, Kalimuthu S, Selander I, McPherson T,
Wilson G, Chan-Seng-Yue M, Borozan I, Ferretti V, Grant R, Lungu I, Costello-Goldring
E, Greenhalf W, Palmer D, Ghaneh P, Neoptolemos J, Buchler M, Petersen G, Thayer S,
Hollingsworth M, Sherker A, Durocher D, Dhani N, Hedley D, Serra S, Pollett A, Roehrl
M, Bavi P, Bartlett J, Cleary S, Wilson J, Alexandrov L, Moore M, Wouters B, McPherson
J, Notta Faiyaz, Stein L, Gallinger S. Distinct mutational signatures are associated with
correlates of increased immune activity in pancreatic ductal adenocarcinoma. JAMA
Oncology. 2016 Oct 20. doi: 10.1001/jamaoncol.2016.3916. [Epub ahead of print]
Saung MT, Sharei A, Adalsteinsson VA, Cho N, Kamath T, Ruiz C, Kirkpatrick J, Petal
N, Mino-Kenudson M, Thayer SP, Langer R, Jensen KF, Liss AS, Love JC. A sizeselective intracellular delivery platform. Small. 2016. Sep 4. doi: 10.1002/smll.201601155.
[Epub ahead of print].
Rosembaum M; Cauley C; Kulemann B; Liss A; Fernandez C; Warshaw A; Lillemoe K;
Thayer S; Pitman M. Cytologic Characteristics of Circulating Epithelioid Cells in
Pancreatic Disease. Accepted Cancer Cytopathology, January 26, 2017.
Submitted:
1.
Geller LT; Barzily-Rokni M; Danino T; Jonas OH; Shental N; Nejman D; Cooper ZA;
Shee K; Thaiss CA; Reuben A; Livny J; Avraham R; Frederick DT; Ligorio M; Chatman
K; Johnston SE; Mosher CM; Smith DA; Skalak M; Bu J; Michaud M; Traugher SA;
Flaherty KT; Mandinova A; Garrett WS; Thayer SP; Ferrone CR; Huttenhower C; Bhatia
SN; Gevers D; Wargo JA; Golub TR; Straussman R. Intra-tumor bacteria elicit drug
resistance in pancreatic ductal adenocarcinoma. Submitted to Science 06/2016
Sarah P. Thayer, M.D., Ph.D.
Page 24
Reviews, Chapters, and Editorials:
1.
2.
3.
4.
5.
6.
7.
Thayer SP, Warshaw AL. “Periampullary Cancer” (chapter). 8th Edition, Current Surgical
Therapy (John L. Cameron, Editor). Philadelphia: Elsevier Mosby, 2004, pp. 494-504.
Alsfasser G, Warshaw AL, Thayer SP, Antoniu B, Laposata M, Lewandrowski K, Klar E,
Fernández-del Castillo C. “Aktiviertes Protein C hemmt die Entzündungsreaktion und
verbessert das Überleben bei experimenteller akuter Pankreatitis“ [Activated Protein C
decreases inflammation and improves survival in experimental acute pancreatitis].
Chirurgisches Forum 2005 (M. Rothmund, K.-W. Jauch and H. Bauer, Editors).
Berlin/Heidelberg, Springer, 2005, pp. 235-236.
Thayer SP. “Commentary on: Lin JW, Leach SD. Pancreatic development.” Chapter 5 in
Pancreatic Cancer (R. H. Ruban et al., Editors). Sudbury, MA: Jones and Bartlett
Publishers, 2005, pp. 84-86.
Boland GM, Thayer SP. “Molecular signaling pathways in pancreatic cancer.” Chapter
11 in Pancreatic Cancer (Andrew Lowy, Steven Leach, and Philip Philip, Editors). New
York: Springer, 2008, pp. 181-228.
Alsina J, Thayer SP. “Hereditary pancreatic cancer.” Chapter in MGH Guide to Clinical
Cancer Genetics (Daniel Chung, Editor). New York: Springer, 2010, pp. 89-96.
Liss AS, Thayer SP. Therapeutic targeting of pancreatic stroma. Chapter 9 in: Pancreatic
Cancer and the Tumor Microenvironment: Mesenchyme’s Role in Pancreatic Carcinogenesis
(Paul J. Grippo and Hidayatullah G. Munshi, Editors). Trivandrum (India): Transworld
Research Network, 2012. PMID: 22876383.
Thayer SP, Nakul V. Acute Pancreatitis. Chapter 11 in Current Surgical Therapy, 11th
Edition (Andrew Cameron, Editor). New York: Elsevier, 2013, pp. 431-39.
Doctoral Dissertation:
1.
Thayer SP. “Transcriptional activation of the MDR1 gene in retinoic acid stimulated
neuroblastoma cells involves derepression and activation by multiple Sp family
members.“ Ithaca, NY: Cornell University, 1999.
Abstracts and Presentations:
1. Lee V, Chen J, Dubois M, Thayer SP, McNamara S. Continuous muscle relaxant infusion
with EMG monitoring. Annual Meeting, Southern Medical Association, Atlanta, GA,
1986.
2. Thayer SP. “An upstream binding element is required for retinoic acid-stimulated
transcription of the MDR1 promoter in human neuroblastoma cells.” Presentation,
Annual Meeting, AACR, San Diego, CA, April 12-16, 1997.
3. Friedman D, Thayer SP, Scotto KW. “Activation of MDR1 gene in retinoic acidstimulated neuroblastoma cells involves derepression and activation by multiple Sp
family members.“ Presentation, Annual Meeting, AACR, Philadelphia, PA, April 10-14,
1999.
4. Balcom JH, Keck T, Warshaw AL, Thayer SP, Antoniu B, Graeme-Cook F, Fernandezdel-Castillo C. “Prevention of clinically significant pancreatic fistulae with a new,
absorbable hydrogel sealant after distal pancreatectomy in the dog.” Poster, Annual
Meeting SSAT, Atlanta, GA, May 21, 2001.
Sarah P. Thayer, M.D., Ph.D.
Page 25
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
15.
Fernández-del Castillo C, Targarona J, Thayer SP, Brugge WR, Warshaw AL.
“Incidental pancreatic cysts: Clinicopathological characteristics and comparison to
symptomatic patients.” 2002 Annual Meeting, New England Surgical Society, Dixville,
NH, September 27-29, 2002.
Thayer SP, Roberts D, Nielsen C, Fernández-del Castillo C, Warshaw AL. “The
developmental signaling factor Sonic Hedgehog is abnormally expressed in neoplastic
pancreata and drives an intestinal metaplasia of the adult human pancreas.” Poster,
Annual Meeting APA, Chicago, IL, November 14-15, 2002.
Stein SL, Warshaw AL, Fernández-del Castillo C, Lauwers GY, Sahani D, Thayer SP.
Autoimmune pancreatitis masquerading as pancreatic cancer: A diagnostic dilemma.
84th Annual Meeting, New England Surgical Society, September 19-23, 2003, Newport,
RI.
Thayer SP, Roberts D, Nielsen C, Fernández-del Castillo C, Warshaw AL. “To
characterize the contribution of Sonic hedgehog to pancreatic neoplasia.” Scientific
Advisory Committee Symposium MGH, Boston, MA, February 5, 2003.
Salvia R, Fernández-del Castillo C, Bassi C, Thayer S, Falconi M, Pederzoli P, Warshaw
AL. “Can malignancy be predicted in main duct intraductal papillary mucinous tumors
of the pancreas (IPMNs)?” Pancreas Club, Orlando, FL, May 18, 2003.
Alsfasser G, Targarona J, Thayer SP, Warshaw AL, Fernández-del Castillo C. “Is serum
CA-19-9 useful in the evaluation of patients with cystic lesions of the pancreas?” Poster,
Annual Meeting APA, Chicago, IL, November 6-7, 2003.
Thayer SP, Roberts DJ, Nielsen CM, Lauwers GY, Fernández-del Castillo C, Antoniu B,
Yajnik V, Alsfasser G, Warshaw AL. “Hedgehog, an early mediator of pancreatic cancer
tumorigenesis, links altered developmental programs to pancreatic neoplasia.”
Presentation, Annual Meeting APA, Chicago, IL, November 6-7, 2003 (Hirshberg Award
for Best Presentation).
Rosow DE, Balcom JH, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Chemically
induced pancreatic ductal adenocarcinomas in mice express Sonic hedgehog.” Poster,
94th Annual Meeting, Molecular Targets and Cancer Therapeutics, AACR, Boston, MA,
November 17-21, 2003.
Salvia R, Fernández-del Castillo C, Bassi C, Thayer SP, Falconi M, Pederzoli P, Warshaw
AL. “Main duct intraductal papillary mucinous neoplasms (IPMNs) of the pancreas:
Clinical predictors of malignancy and long-term survival following resection.”
Presentation, Annual Meeting, Southern Surgical Association, Hot Springs, VA,
December 1-3, 2003.
Rosow DE, Balcom JH, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Chemically
induced pancreatic ductal adenocarcinomas in mice misexpress the Sonic hedgehog
pathway.” Poster, Scientific Advisory Committee Symposium, February 5, 2004, MGH,
Boston, MA.
Rosow DE, Balcom JH, Trainor AG, Strobel O, Antoniu B, Li L, Fernández-del Castillo C,
Warshaw AL, Thayer SP. “Sonic hedgehog is abnormally expressed in
dimethylbenzanthracene (DMBA)-induced pancreatic neoplasia and drives a
gastrointestinal metaplasia of the adult mouse pancreas.” Poster, 95th Annual Meeting
AACR, Orlando, FL, March 27-31, 2004.
Strobel O, Trainor A, Li L, Antoniu B, Rosow DE, Fernández-del Castillo C, Warshaw
AL, Thayer SP. Sonic hedgehog is misexpressed in the epithelium of branches of the
Sarah P. Thayer, M.D., Ph.D.
Page 26
16.
17.
18.
19.
20.
21.
22.
23.
24.
pancreatic main duct in response to inflammation: Role in pancreatic carcinogenesis.
Poster, 95th Annual Meeting AACR, Orlando, FL, March 27-31, 2004.
Thayer SP, Roberts DJ, Nielsen CM, Lauwers GY, Strobel O, Rosow DE, Fernández-del
Castillo C, Warshaw AL. “The Hedgehog pathway: an initiator and maintenance factor
for pancreatic cancer.” Poster, Lustgarten Foundation for Pancreatic Cancer
Research/AACR Meeting “Pancreatic Cancer 2004: Advances and Challenges,” San
Francisco, CA, June 25-26, 2004.
Rosow D, Balcom JH, Trainor AG, Strobel O, Antoniu B, Li L, Fernández-del Castillo C,
Warshaw AL, Thayer SP. “Implantation of dimethylbenzanthracene in mice induces
pancreatic ductal adenocarcinomas that misexpress the sonic hedgehog pathway.”
Poster, Joint Meeting, 11th Meeting of the International Association of Pancreatology and
35th Annual Meeting of the Japan Pancreas Society, Sendai, Japan, July 11-14, 2004.
Published in Journal of the Japan Pancreas Society 19(3):285 (2004).
Strobel O, Trainor A, Li L, Antoniu B, Rosow DE, Fernández-del Castillo C, Warshaw
AL, Thayer SP. “Sonic hedgehog is upregulated in response to inflammation in the
epithelium of main duct branches: role in pancreatic carcinogenesis.” Poster, Joint
Meeting, 11th Meeting of the International Association of Pancreatology and 35th Annual
Meeting of the Japan Pancreas Society, Sendai, Japan, July 11-14, 2004. Published in
Journal of the Japan Pancreas Society 19(3):241-242 (2004).
Thayer SP, Dor Y, Melton D, Strobel O, Rosow DE, Fernández-del Castillo C, Trainor A,
Li L, Warshaw AL. “Carcinogen-induced tubular formations are not of islet cell origin.”
Presentation, Joint Meeting, 11th Meeting of the IAP and 35th Annual Meeting of the
Japan Pancreas Society, Sendai, Japan, July 11-14, 2004. Published in Journal of the Japan
Pancreas Society 19(3):241 (2004).
Alsfasser G, Warshaw AL, Thayer SP, Laposata M, Lewandrowski KB, Fernández-del
Castillo C. “Activated protein C decreases inflammation and improves survival in
experimental acute pancreatitis.” Presentation, Joint Meeting, 11th Meeting of the
International Association of Pancreatology and 35th Annual Meeting of the Japan
Pancreas Society, Sendai, Japan, July 11-14, 2004.
Rosow DE, Strobel O, Trainor AG, Fernández-del Castillo C, Warshaw AL, Thayer SP.
“Hedgehog and its pathway members are misexpressed and active in the majority of
sporadic human pancreatic adenocarcinomas: A biologically important pathway and
potential therapeutic target.” Presentation, Annual Meeting, APA, Chicago, IL,
November 4-5, 2004. Published in Pancreas 29(4):338, November 2004.
Strobel O, Rosow DE, Trainor AG, Lauwers AG, Li L, Antoniu B, Fernández-del Castillo
C, Warshaw AL, Thayer SP. “Duct glands of the pancreatic head up-regulate Shh, GI
mucins and rate of proliferation in response to chronic injury and inflammation: Possible
origin of pancreatic cancer?” Poster, Annual Meeting, APA, Chicago, IL, November 4-5,
2004. Published in Pancreas 29(4):338-339 (2004).
Strobel O, Rosow DE, Trainor AG, Lauwers GY, Fernández-del Castillo C, Warshaw AL,
Thayer SP. “Duct glands of the pancreatic head upregulate sonic hedgehog and GIspecific mucins in response to chronic injury: stem cells of pancreatic cancer?” Poster,
96th Annual Meeting, AACR, Anaheim, CA, April 16-20, 2005.
Ferrone CP, Thayer SP, Finkelstein DM, Muzikansky A, Mino-Kenudson M, Lauwers G,
Warshaw AL. “A decrease in preoperative to postoperative CA19-9 level is a significant
predictor of survival in patients with pancreatic adenocarcinoma.” Poster and
Sarah P. Thayer, M.D., Ph.D.
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25.
26.
27.
28.
29.
30.
31.
32.
33.
Presentation (Merit Award winner), Annual Meeting, ASCO, Orlando, FL, May 13-17,
2005. Published in J Clin Oncol 2005 ASCO Annual Meeting Proceedings 23:4034.
Strobel O, Rosow DE, Trainor AG, Lauwers GY, Fernández-del Castillo C, Warshaw AL,
Thayer SP. “Duct glands of the pancreatic head upregulate sonic hedgehog as well as
gastric and intestinal mucins in response to chronic inflammation: Gastrointestinal
metaplasia an early event in pancreatic carcinogenesis.” Poster presentation, American
Gastroenterological Association, DDW, Chicago, IL, May 14-19, 2005.
Rosow DE, Sahani DV, Strobel O, Alsfasser G, Mino-Kenudson M, Kalva S, Saini S, Lee
SI, Wittenberg J, Mueller PR, Fernández-del Castillo C, Warshaw AL, Thayer SP.
“Imaging of acute mesenteric ischemia using 16-multi-detector row CT and CT
angiography in a porcine model: description of disease evolution with surgical
correlation.” Presentation, Presidential Plenary Session, SSAT, DDW, Chicago, IL, May
14-19, 2005 (published in J Gastrointest Surg).
Thayer SP, Dor Y, Melton D, Strobel O, Mino-Kenudson M, Lauwers G, Rosow DE,
Fernández-del Castillo C, Warshaw AL. “Carcinogen-induced tubular formations are
not of acinar cell origin.” Presentation, Pancreas Club, DDW, Chicago, IL, May 14-19,
2005.
Strobel O, Lauwers GY, Fernández-del Castillo C, Warshaw AL, Thayer SP.
“Differential expression of the developmental factors Sonic Hedgehog and Pdx-1
appears to determine the phenotype of pancreatic ductal epithelium in response to
chronic injury.” Poster and Presentation, Pancreas Cancer 2005: State-of-the-Art,
Lustgarten Foundation for Pancreatic Cancer Research/Memorial Sloan-Kettering
Cancer Center, New York, NY, June 23-24, 2005.
Rodriguez R, Soto Germes S, Pandharipande PV, Gazelle GS, Thayer SP, Warshaw AL,
Fernández-del Castillo C. “Implications and cost of pancreatic leak following distal
pancreatic resection.” 12th Annual Surgical Resident and Fellow Research Presentation
Day, New England Surgical Society, Boston, MA, May 27, 2005; awarded First Place for
Best Clinical Presentation and presented at the Society's 86th Annual Meeting, Bretton
Woods, NH, September 30, 2005.
Long DD, Munn LL, Mino-Kenudson M, Antoniu B, Strobel O, Fernández-del Castillo C,
Warshaw AL, Thayer SP. “Sonic hedgehog (Shh): A potent angiogenic factor necessary
for tumor growth?” Presentation, Annual Meeting, APA, Chicago, IL, November 3-4,
2005.
Stirman A, Strobel O, Mikhaylova E, Fernández-del Castillo C, Warshaw AL, Thayer SP.
“Generation of a mouse model, Pdx-Shh, which develops precursor lesions of pancreatic
cancer (PanINs) from normal ducts.” Poster, Annual Meeting, APA, Chicago, IL,
November 3-4, 2005.
Strobel O, Dor Y, Stirman A, Mikhaylova E, Trainor A, Fernández-del Castillo C,
Warshaw AL, Thayer SP. “Tubular complexes are not of β-cell origin: genetic lineage
tracing in a mouse model of pancreatitis.” Poster, Annual Meeting, APA, Chicago, IL,
November 3-4, 2005.
Strobel O, Lauwers GY, Fernández-del Castillo C, Warshaw AL, Thayer SP. “PanIN 1A
or duct glands of the pancreas?” Anatomic proof and characterization of a specialized
compartment of the ductal system. Poster, Annual Meeting, APA, Chicago, IL,
November 3-4, 2005. Published in Pancreas 31(4):471-472 (2005).
Sarah P. Thayer, M.D., Ph.D.
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Rakhlin EY, Rosow DE, Mino-Kenudson M, Stirman AM, Mikhaylova EA, Long D,
Fernández-del Castillo C, Warshaw AL, Thayer SP. “Differentiation status may predict
response to Hedgehog pathway inhibition in pancreatic adenocarcinoma.” Poster,
Annual Meeting, APA, Chicago, IL, November 3-4, 2005. Published in Pancreas 31(4):464
(2005).
Rakhlin EY, Mino-Kenudson M, Warshaw AL, Thayer SP. “Characterization of Sonic
hedgehog expression and Hedgehog pathway activity in Barrett's esophagus and
esophageal adenocarcinoma.” Poster, 97th Annual Meeting, AACR, Washington, DC,
April 1-5, 2006.
Hung YP, Thayer SP. “Familial pancreatic disease study.” Presentation, Soma Weiss
Day, Harvard Medical School, Boston, MA, September 2006.
Vagefi PA, Razo O, Deshpande V, McGrath DJ, Lauwers GY, Thayer SP, Warshaw AL,
Fernández-del Castillo C. “Evolving patterns in the detection of pancreatic
neuroendocrine tumors (PNETs): The Massachusetts General Hospital experience.”
Podium presentation, 2006 Annual Meeting, New England Surgical Society, Groton, CT,
September 15-17, 2006.
Vagefi PA, Razo O, Deshpande V, McGrath DJ, Lauwers GY, Thayer SP, Warshaw AL,
Fernández-del Castillo C. “Evolving patterns in the detection of pancreatic
neuroendocrine tumors (PNETs): The Massachusetts General Hospital experience.”
Poster, 2006 APA-IAP Joint Meeting, Chicago, IL, November 1-4, 2006.
Alsina J, Stirman A, Mino-Kenudson M, Fernández-del Castillo C, Warshaw A, Thayer
SP. “Shh misexpression in the adult pancreas results in the expansion of both a
mucinous ductal metaplasia and a fibrosing mesenchyme.” Poster, 2006 APA-IAP Joint
Meeting, Chicago, IL, November 1-4, 2006. Published in Pancreas 33(4):443 (2006).
Guimaraes AR, Rakhlin EY, Long D, Weissleder R, Thayer SP. “Noninvasive MRI
imaging: A sensitive indicator of physiologic changes accompanied with anti-hedgehog
therapy in a pancreatic ductal adenocarcinoma (PDAC) xenograft model.” Poster, 2006
APA-IAP Joint Meeting, Chicago, IL, November 1-4, 2006. Published in Pancreas
33(4):465-466 (2006).
LaFemina J, Stirman A, Alsina J, Mino-Kenudson M, Fernández-del Castillo C, Warshaw
AL, Thayer SP. “Challenging the role of the p16 mutation in the development of
pancreatic adenocarcinoma.“ Presentation, 41st Annual Meeting, Pancreas Club,
Washington, DC, May 20, 2007.
Alsina J, Stirman A, Mino-Kenudson M, Fernández-del Castillo C, Warshaw A, Thayer
SP. “Sonic hedgehog misexpression directs epithelial and mesenchymal changes
important in initiation of the pancreatic cancer phenotype.” 41st Annual Meeting,
Pancreas Club, Washington, DC, May 20, 2007.
Crippa S, Salvia R, Warshaw AL, Dominguez I, Bassi C, Falconi M, Thayer SP, Zamboni
G, Lauwers G, Mino-Kenudson M, Pederzoli P, Fernández-del Castillo C. “Mucinous
cystic neoplasm of the pancreas is not an aggressive entity.” Lessons from 163 resected
patients. 41st Annual Meeting, Pancreas Club, Washington, DC, May 20, 2007.
LaFemina J, Roberts P, Hung Y, Gusella J, Sahani D, Fernández-del Castillo C, Warshaw
A, Thayer SP. “Identification of a novel kindred with familial pancreatitis and
pancreatic cancer.” Poster, DDW& SSAT, Washington, DC, May 21, 2007 (Poster of
Distinction).
Sarah P. Thayer, M.D., Ph.D.
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LaFemina J, Roberts P, Hung Y, Gusella J, Sahani D, Fernández-del Castillo C, Warshaw
A, Thayer SP. “Identification of a novel kindred with familial pancreatitis and
pancreatic cancer.” MGH Research Fellows’ Poster Celebration, Boston, MA, June 1,
2007 (Honorable Mention).
Fritz S. “Pancreatic cancer tumor response to Hedgehog pathway inhibition in a
xenograft model.” Presentation, Karin Grunebaum Research Foundation, Harvard
Medical School, Boston, MA, June 8, 2007.
Strobel O, Dor Y, Alsina J, Stirman A, Lauwers G, Trainor A, Fernández-del Castillo C,
Warshaw A, Thayer S. “In vivo lineage tracing defines the role of acinar-to-ductal
transdifferentiation in inflammation-mediated ductal metaplasia.” Presentation, Annual
Meeting, APA, Chicago, IL, November 1-3, 2007.
LaFemina J, Stirman A, Alsina J, Mino-Kenudson M, Fernández-del Castillo C, Warshaw
AL, Thayer SP. “Paradoxical inhibition of ductal proliferation due to SHH
misexpression with p16-/- is accompanied by pluripotential cell expansion.”
Presentation, Annual Meeting, APA (Pancreatic Cancer 2007: Stem Cells in the Pancreas
and Pancreatic Cancer), Chicago, IL, November 3, 2007; published in Pancreas 2007:
35(4):409-410.
LaFemina J, Stirman A, Alsina J, Mino-Kenudson M, Fernández-del Castillo C, Warshaw
A, Thayer S. “Shh misexpression with p16-/- results in stimulation of pancreatic
progenitor cells and paradoxical normalization of pancreatic neoplastic phenotype.”
Poster, 54th Annual Meeting, Massachusetts Chapter, ACS, Boston, MA, December 8,
2007.
Fritz S, Fernández-del Castillo C, Mino-Kenudson M, Crippa S, Batten JM, Nguyen AT,
Thayer SP, Deshpande V, Lauwers GY, Warshaw AL, Iafrate AJ. “Current
chromosomal aberrations in intraductal papillary mucinous neoplasms (IPMNs).”
Presentation, 42nd Annual Meeting, Pancreas Club, San Diego, CA, May 18, 2008.
Fritz S, Fernández-del Castillo C, Mino-Kenudson M, Crippa S, Miller JM, Thayer SP,
Deshpande V, Lauwers GY, Warshaw AL, Iafrate AJ. “Detection of chromosomal
aberrations in intraductal papillary mucinous neoplasms by comparative genomic
hybridization.” Poster, DDW & 49th Annual Meeting SSAT, San Diego, CA, May 21,
2008.
Fritz S, Fernández-del Castillo C, Iafrate AJ, Mino-Kenudson M, Neyhard N, LaFemina
J, Stirman A, Warshaw AL, Thayer SP. “A xenograft model and cell line deriving from
invasive intraductal papillary mucinous neoplasm of the pancreas.” Poster, DDW & 49th
Annual Meeting SSAT, San Diego, CA, May 19, 2008.
Ferrone CR, Warshaw AL, Rodriguez JR, Thayer SP, Fernández-del Castillo C.
“Pancreatic fistula rates after 442 distal pancreatectomies: staplers do not decrease fistula
rates.” Presentation, 49th Annual Meeting SSAT, San Diego, CA, May 20, 2008.
LaFemina J, Roberts P, Hung Y, Gusella J, Sahani D, Fernández-del Castillo C, Warshaw
A, Thayer S. “Identification of a novel kindred with familial pancreatitis and pancreatic
cancer.” Poster, 42nd Annual Meeting, Pancreas Club, San Diego, CA, May 18, 2008.
Strobel O, Rosow DE, Rakhlin EY, Lauwers GY, Trainor AG, Fernández-del Castillo C,
Warshaw AL, Thayer SP. “Pancreatic duct glands, a specialized ductal compartment
reactive to chronic injury and involved in Shh-driven mucinous metaplasia.” Presented
to the Joint Meeting of the European Pancreatic Club (EPC) and the IAP, Lodz, Poland,
June 26, 2008.
Sarah P. Thayer, M.D., Ph.D.
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Androutsopoulos V, Dominguez I, Ferrone C, Fernández-del Castillo C, Warshaw AL,
Thayer SP. “Does gemcitabine improve survival in resected pancreatic cancer patients?”
Poster, Annual Meeting, APA, Chicago, IL, November 6-8, 2008.
Nehra D, Mino-Kenudson M, Thayer SP, Ferrone C, Finkelstein D, Silver M, Warshaw
AL, Fernández-del Castillo C. “Intraductal papillary mucinous neoplasms: A genetic
disease?” Poster, Annual Meeting, APA, Chicago, IL, November 6-8, 2008.
Konstantinidis I, Deshpande V, Catalano OA, Forcione DG, Sahani D, Fernández-del
Castillo C, Thayer SP, Warshaw AL, Ferrone CR. “Lymphoepithelial cysts of the
pancreas: Report of a single institution experience of 8 cases.” Poster, Annual Meeting,
APA, Chicago, IL, November 6-8, 2008.
Correa-Gallego C, Ferrone C, Sahani D, Forcione D, Brugge W, Thayer SP, Warshaw AL,
Fernández-del Castillo C. “Incidentally discovered pancreatic cysts: What evaluation is
useful?” Presentation, Annual Meeting, APA, Chicago, IL, November 6-8, 2008.
Bausch D, Mino-Kenudson M, Warshaw AL, Thayer SP, Kelly K. “Plectin-1 as a novel
imaging marker in pancreatic cancer.” Presentation, Annual Meeting, APA, Chicago, IL,
Nov. 6-8, 2008.
Bausch D, Mino-Kenudson M, Fernández-del Castillo C, Warshaw AL, Thayer SP, Kelly
K. “Plectin-1 as a novel imaging biomarker for pancreatic cancer.” Presentation,
Pancreas Club, Chicago, IL, May 30, 2009.
Correa-Gallego C, Ferrone C, Thayer SP, Wargo JA, Warshaw AL, Fernández-del
Castillo C. “Incidental pancreatic cysts: Do we really know what we are watching?”
Presentation, Pancreas Club, Chicago, IL, May 30, 2009.
Androutsopoulos V, Thayer SP. “Does Gemzar improve survival in resected pancreatic
cancer patients?” Presentation, Pancreas Club, Chicago, IL, May 31, 2009.
Konstantinidis I, Genevay M, Brugge WR, Thayer SP, Ferrone CR, Fernández-del
Castillo C, Lauwers GY, Deshpande V. “Cytology plays a key role in the identification of
malignancy in pancreatic cysts.” In analysis of 175 histologically confirmed cases.
Presentation, DDW 2009, Chicago, IL (S1294).
Konstantinidis I, Deshpande V, Fernández-del Castillo C, Warshaw AL, Lauwers GY,
Androutsopoulos V, Thayer SP, Ferrone CR. “Does the mechanism of lymph node
invasion affect survival in patients with pancreatic cancer?” Presentation, DDW 2009,
Chicago, IL (T1587).
Crippa S, Fernández-del Castillo C, Salvia R, Finkelstein DM, Bassi C, Dominguez I,
Capelli P, Mino-Kenudson M, Lauwers TY, Falconi M, Thayer SP, Partelli S, Pederzoli,
Warshaw AL. “Main-duct and combined IPMNs are the same clinical entity and distinct
from branch-duct IPMNs.” Presentation, DDW 2009, Chicago, IL (967).
Fritz S, Fernández-del Castillo C, Mino-Kenudson M, Crippa S, Miller JM, Thayer SP,
Deshpande V, Lauwers GY, Warshaw AL, Iafrate AJ. “Detection of chromosomal
aberrations in intraductal papillary mucinous neoplasms by comparative genomic
hybridization.” Presentation, DDW 2009, Chicago, IL (W1414).
Fritz S, Fernández-del Castillo C, Iafrate AJ, Mino-Kenudson M, Neyhard NL, LaFemina
J, Stirman A, Warshaw AL, Thayer SP. “A xenograft model and cell line deriving from
invasive intraductal papillary mucinous neoplasm of the pancreas.” Presentation, DDW,
Chicago, IL, June 3, 2009.
Sarah P. Thayer, M.D., Ph.D.
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Bausch D, Mino-Kenudson M, Fernández-del Castillo C, Warshaw AL, Kelly K, Thayer
SP. Plectin-1 as a biomarker in malignant pancreatic intraductal papillary mucinous
tumors. Presentation, SSAT, DDW, Chicago, IL, June 3, 2009.
Boni A, Thayer SP, Ferrone C, Bausch D, Neyhard N, Cogdill A, Fernández-del Castillo
C, Warshaw AL, Wargo JA. “Immunotherapeutic and epigenetic approaches targeting
cancer-testis antigens in the treatment of pancreatic cancer.” Poster, Annual Meeting
APA and Japanese Pancreas Society, Honolulu, HI, November 4-7, 2009.
Konstantinidis IT, Dursun A, Bordeianou L, Wargo J, Thayer SP, Fernández-del Castillo
C, Warshaw AL, Ferrone CR. Metastatic tumors to the pancreas in the modern era.
Poster, Annual Meeting APA and Japanese Pancreas Society, Honolulu, HI, November 47, 2009.
Ferrone CR, Konstantinidis IT, Fernández-del Castillo C, Wargo J, Thayer SP, Warshaw
AL. “Fifteen years of the Warshaw technique.” Poster, Annual Meeting APA and
Japanese Pancreas Society, Honolulu, HI, November 4-7, 2009.
Correa-Gallego C, Ferrone CR, Thayer SP, Wargo JA, Warshaw AL, Fernández-del
Castillo C. “Are multifocal pancreatic cysts an indolent condition?” Poster, Annual
Meeting APA and Japanese Pancreas Society, Honolulu, HI, November 4-7, 2009.
Correa-Gallego C, Mino-Kenudson M, Ferrone C, Thayer SP, Wargo JA, Warshaw AL,
Fernández-del Castillo C. “Non-neoplastic cysts comprise 8% of resected pancreatic
cysts presumed to be neoplastic.” Poster, Annual Meeting APA and Japanese Pancreas
Society, Honolulu, HI, November 4-7, 2009.
Bausch D, Pausch T, Hopt UT, Fernández-del Castillo C, Warshaw AL, Thayer SP, Keck
T. “Granulocyte MMP-9 is a VEGF-independent component of the angiogenic switch in
PDAC.” Presentation, Annual Meeting APA and Japanese Pancreas Society, Honolulu,
HI, November 4-7, 2009.
Bausch D, Fritz S, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Inhibition of
hedgehog signaling in a PDAC xenograft model inhibits the tumor and its
microenvironment.” Accepted for presentation (with Young Investigator Award), Joint
Meeting, IAP and Japan Pancreas Society, Fukuoka, Japan, July 11-13, 2010.
Park JK, Irimia D, Toner M, Bausch D, Liss A, Fernández-del Castillo C, Warshaw AL,
Thayer SP. “Differences in migration between primary and metastatic PDAC cells.”
Presentation (with Young Investigator Award), Joint Meeting IAP and Japan Pancreas
Society Fukuoka, Japan, July 11-13, 2010.
Park JK, Toner M, Nagrath S, Komen J, Bausch D, Liss A, Fernández-del Castillo C,
Warshaw AL, Thayer SP. “Detection of circulating tumor cells (CTCs) in pancreatic
ductal adenocarcinoma (PDAC).” Presentation (with Young Investigator Award), Joint
Meeting IAP and Japan Pancreas Society Fukuoka, Japan, July 11-13, 2010.
Bausch D, Fritz S, Fernández-del Castillo C, Warshaw AL, Thayer SP. “Inhibition of
hedgehog signaling in a PDAC xenograft model inhibits the tumor and its
microenvironment.” Presentation, Annual Meeting APA, Chicago, IL, November 3-6,
2010.
Park J, Irimia D, Toner M, Bausch D, Liss A, Fernández-del Castillo C, Warshaw AL,
Thayer SP. “Differences in migration between PDAC stem cells and non-stem cells.”
Poster, Annual Meeting, APA, Chicago, IL, November 3-6, 2010.
Sarah P. Thayer, M.D., Ph.D.
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Valsangkar NP, Bush DM, Michaelson JS, Fernández-del Castillo C, Warshaw AL,
Thayer SP. “Race does not substantially affect outcomes in patients with pancreatic
cancer.” Poster, Annual Meeting, APA, Chicago, Nov. 3-6, 2010.
Valsangkar NP, Bush DM, Michaelson JS, Fernández-del Castillo C, Warshaw AL,
Thayer SP. “Prognostic value of lymph node ratio increases with number of lymph
nodes examined: A concomitant review of SEER and a single institution’s patients.”
Poster, 52nd Annual Meeting SSAT, DDW, Chicago, IL, May 6-10, 2011.
Valsangkar NP, Bush DM, Michaelson JS, Fernández-del Castillo C, Warshaw AL,
Thayer SP. “Predicting survival in pancreatic cancer: A comparison of lymph node ratio
with number of metastatic nodes.” Presentation (short), Pancreas Club, DDW, Chicago,
IL, May 6-10, 2011.
Bausch D, Fritz S, Liss A, Fernández-del Castillo C, Warshaw AL, Thayer SP.
“Hedgehog signaling is required for tumor stroma maintenance and tumor angiogenesis
in pancreatic cancer.” Presentation (long), Pancreas Club, DDW, Chicago, IL, May 6-10,
2011.
Mino-Kenudson M, Fernández-del Castillo C, Baba Y, Hsu M, Correa-Gallego C,
Ingkakul T, Perez Johnston R, Turner BG, Androutsopoulos V, McGrath D, Sahani DV,
Brugge WR, Ogino S, Pitman MB, Warshaw AL, Thayer SP. “Prognostic significance of
histologic and precursor epithelial subtypes of invasive intraductal papillary mucinous
neoplasm: improved survival rates compared to pancreatic ductal adenocarcinoma are
limited to indolent colloid and oncocytic types.” Presentation (long), Pancreas Club,
DDW, Chicago, IL, May 6-10, 2011.
Valsangkar NP, Ingkakul T, Correa-Gallego C, Warshaw AL, Fernández-del Castillo C,
Liss AS, Thayer SP. “The G12D mutation of KRAS predicts early recurrence and poor
overall survival in ampullary adenocarcinoma.” Presented, Annual Meeting APA,
Chicago, IL, November 2-5, 2011.
Yamaguchi J, Mino-Kenudson M, Liss AS, Fernández-del Castillo C, Warshaw AL,
Thayer SP. “Pancreatic duct glands (PDG) are the origin of gastric-type IPMN.” Poster,
Annual Meeting APA, Chicago, IL, November 2-5, 2011.
Valsangkar NP, Ingkakul T, Correa-Gallego C, Liss AS, Mino-Kenudson M, Fernándezdel Castillo C, Warshaw AL, Thayer SP. “The prognostic implication of KRAS mutation
in ampullary adenocarcinoma: only the KRASG12D genotype predicts poor survival.”
Presentation, 46th Annual Meeting, Pancreas Club, San Diego, CA, May 18-19, 2012.
Yamaguchi J, Mino-Kenudson M, Liss AS, Lillemoe KD, Fernández-del Castillo C,
Warshaw AL, Thayer SP. “Pancreatic duct glands (PDG) are the origin of gastric-type
IPMN.” Presentation, 46th Annual Meeting, Pancreas Club, San Diego, CA, May 18-19,
2012.
Liss AS, Nahar S, Mertz JA, Sims RJ, Fernández-del Castillo C, Lillemoe KD, Warshaw
AL, Thayer SP. “The BET family of chromatin adaptors are key regulators of cell growth
and Shh expression in pancreatic ductal adenocarcinoma.” Presentation and Poster of
Distinction, 46th Annual Meeting, Pancreas Club, San Diego, CA, May 18-19, 2012.
Kulemann B, Liss AS, Valsangkar NP, Fernández-del Castillo C, Lillemoe KD, MinoKenudson M, Warshaw AL, Pitman MB, Thayer SP. “The capture of CTC for
cytological, molecular and cell culture evaluation in patients with pancreatic cancer.”
Poster of Distinction, 46th Annual Meeting, Pancreas Club, San Diego, CA, May 18-19,
2012.
Sarah P. Thayer, M.D., Ph.D.
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Hedgire Sandeep S, Fernández-del Castillo Carlos, Thayer Sarah, Mino-Kenudson Mari,
Weissleder Ralph, Harisinghani Mukesh G. “Delineating the tumor in pancreatic
adenocarcinoma using USPIO-ferumoxytol: Preliminary findings.” Annual Meeting,
Society of Computed Body Tomography and Magnetic Resonance, Boston, MA, October
6, 2012. Best Translational Science Poster Award.
Yamaguchi J, Mino-Kenudson M, Liss AS, Lillemoe KD, Fernández-del Castillo C,
Warshaw AL, Thayer SP. “Pancreatic duct glands (PDG), a progenitor stem cell niche
responsible for pancreatic epithelial renewal and repair in response to inflammatory
injury.” Poster, Joint Meeting, APA and IAP, Miami, FL, October 31-November 3, 2012.
Sahora K, Mino-Kenudson M, Thayer S, Ferrone C, Brugge W, Sahani D, Pitman M,
Warshaw A, Lillemoe K, Fernández-del Castillo C. “Branch duct intraductal papillary
mucinous neoplasms: Does cyst size change at the tip of the scale? A critical analysis of
the revised international consensus guidelines in a large single-institutional series.”
Presentation, American Surgical Association, 133rd Annual Meeting, Atlanta, GA, April
4-6, 2013.
Ven FZ, Klaus S, Seefeld KJ, Wargo JA Ferrone CR, Thayer SP, Warshaw AL, Lillemoe
KD, Hutter MM, Fernández-del Castillo C. “Understanding hospital readmissions after
pancreaticoduodenectomy: can we prevent them? A 10-year contemporary experience
with 1173 patients at the Massachusetts General Hospital.” Plenary presentation, Annual
Meeting SSAT, Orlando, FL, May 17, 2013.
Goldberg S, Hong TS, Fernández-del Castillo C, Thayer SP, Ferrone CR, Willett C,
Warshaw AL, Ryan DP, Cai S. “IORT prognostic factors for locally advanced pancreatic
cancer.” Poster, American Society for Radiation Oncology (ASTRO), 55th Annual
Meeting, Atlanta, GA, Sept. 22-24, 2013.
Cauley CE, Pittman M, Zhou J, Valsangkar N, Liss A, Fernández-del Castillo C,
Warshaw AL, Lillemoe KD, Thayer SP. “Prognostic value of circulating tumor cells in
patients with pancreatic adenocarcinoma.” 44th Annual Meeting APA, Miami Beach, FL,
Oct. 31-Nov. 2, 2013.
Yamaguchi J, Mino-Kenudson M, Liss AS, Lillemoe KD, Fernández-del Castillo C,
Warshaw AL, Thayer SP. “Loss of TFF2 in pancreatic duct glands (PDG) results in the
formation of IPMN, suggesting TFF2 may function as a tumor suppressor.” 44th Annual
Meeting APA, Miami Beach, FL, October 31-November 2, 2013.
Marchegiani G, Mino-Kenudson M, Morales-Oyarvide V, Thayer S, Ferrone C,
Warshaw AL, Lillemoe K, Fernández-del Castillo C. “IPMN involving the main
pancreatic duct: biology, epidemiology, and long-term outcomes following resection.”
44th Annual Meeting APA, Miami Beach, FL, October 31-November 2, 2013.
Liss AS, Nahar S, Mertz J, Bryant B, Sims R III, Fernández-del Castillo C, Lillemoe K,
Warshaw AL, Thayer SP. “BET proteins are key mediators of tumor cell growth and the
microenvironment in pancreatic cancer.” 44th Annual Meeting APA, Miami Beach, FL,
October 31-November 2, 2013.
Chowdhury S, Klinkebiel D, Yamaguchi J, Liss AS, and Thayer SP. “TFF2/Smad4 tumor
suppressor signaling in pancreatic cancer is regulated by promoter methylation.” 46th
APA Annual Meeting, San Diego, CA, November 4-7, 2015 (Poster of Distinction)
Chowdhury S, Ali M, Yamaguchi J, Liss AS, Sontheimer A, and Thayer SP. “Novel
TFF2/DPYSL3 interaction in Smad4-mediated tumor suppressor signaling in pancreatic
cancer.” 46th APA Annual Meeting, San Diego, CA, November 4-7, 2015.
Sarah P. Thayer, M.D., Ph.D.
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104.
Chowdhury S, Ali M, Maroni D, Woods N, and Thayer SP. “DPYSL3 variant 1 regulates
cell survival in pancreatic cancer.” 46th American Pancreatic Association (APA) Annual
Meeting, San Diego, CA, November 4-7, 2015.
Thayer SP. “The ampulla is a reservoir for Lgr5-derived secretory cells that migrate to
the pancreas following injury,” 46th Annual Meeting of APA, San Diego, CA, November
4-7, 2015
Professional and Public Service Engagements
Nov 2014
“Interview with an Expert: Surgery.” Published in Cure Pancreatic
Cancer, Lustgarten Foundation. www.lustgarten.org
Jan 20, 2015
Opening remarks at the Pre-radio-thon Meeting for NRG Media, Omaha,
NE
Mar 2, 2015
Interview for video for NRG Media Radio-thon
Mar 2, 2015
Interview for NET program, “Living with Cancer in Nebraska”
Mar 7, 2015
Represented the F&PBCC at the Team Jack Gala in Lincoln, NE
Mar 21, 2015
Attended the Ambassador of Hope Gala
Mar 25, 2015
Participated in a Panel Discussion for NET program on cancer in
Nebraska
Apr 17, 2015
Represented the F&PBCC at Kicks for a Cure
Apr 18, 2015
Represented the F&PBCC at the Omaha Symphony Gala
Oct 9, 2015
Interview for the Midlands Business Journal
Oct 27, 2015
Participated/Photos for the UNe Campaign
Jan 13, 2016
Interviewed by the Omaha World Herald for an article which appeared
on Jan 14, 2016
Jan 13, 2016
Interviewed by KETV for video story: “Cancer cure plays important role
with local family”
Jan 20, 2015
Opening remarks at the Pre-Radio-Thon Meeting for NRG Media
Mar 2, 2015
Interview for video for NRG Media Radio-Thon
Mar 2, 2015
Interview for NET TV Program, “Living with Cancer in Nebraska”
Mar 7, 2015
Represented the F&PBCC at the Team Jack Gala in Lincoln, NE
Mar 21, 2015
Represented the F&PBCC at the Ambassador of Hope Gala
Mar 25, 2015
Participated in a Panel Discussion in Lincoln, NE, for an NET Program on
cancer in Nebraska
Apr 17, 2015
Represented the F&PBCC at Kicks for a Cure
Apr 18, 2015
Represented the F&PBCC at the Omaha Symphony Gala, Omaha, NE
Oct 9, 2015
Provided a statement and photo for the “Midlands Business Journal”
Oct 27, 2015
Participated in a UNe campaign
Oct 28, 2015
Interviewed with Sue Myer for a new F&PBCC publication
Jan 13, 2016
Interviewed by the Omaha World Herald for an article which appeared on
January 14, 2016, entitled, “Education Cure is a ‘mighty word,’ but
emerging science, Obama’s encouragement holds promise for cancer
patients, Omaha docs say.”
Jan 13, 2016
Interviewed by TV station, KETV, for video story: “Cancer cure effort
plays important role with local family.”
Feb 2, 2016
Participated in a marketing photoshoot for the Multidisciplinary Clinic
(MDC)
Sarah P. Thayer, M.D., Ph.D.
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Feb 13-15, 2016
Mar 8, 2016
Apr 25, 2016
May 17, 2016
July 13, 2016
July 22, 2016
Sept 12, 2016
Oct 3, 2016
Oct 1, 2016
Oct 2016
Presentation concerning the F&PBCC at the NU Foundation event in
Scottsdale, AZ
Participated in a physician recruitment video shoot for Provider Network
Services
Participated in an outreach dinner with St. Francis Medical Center, Grand
Island, NE
Attended the Mother/Daughter Brunch to discuss women’s cancer
services, Omaha, NE
Presented at the Optum Health Conference, Century Link Center,
Omaha, NE
Attended the American Cancer Society’s Hope in the Heartland Gala at
Baxter Arena, Omaha, NE
Attended an outreach dinner with Heartland Oncology & Hematology.
Traveled to Lincoln, NE, to provide an update to Senators and President
Hank Bounds concerning the F&PBCC during pre-game activities. Also
presented brief remarks on the Half Time Radio Network with Dr.
Bounds concerning the current status of the cancer center’s opening, as
well as cancer research and care
Social share, “The Buffett Cancer Center is recruiting the best of the
best—researchers and physicians in top positions at national-level
programs and prestigious institutions. They see what we’re doing for
cancer care and research, and they want to be part of it.”
Included in an advertisement for the University of Nebraska to detail the
F&PBCC, https://nebraska.edu/impact/.