Section 1 - General Information
Chemical Name:
Cyclosporin A-d4
CAS Reg. Number:
Catalog Number:
sc-217987
Supplier:
Santa Cruz Biotechnology, Inc.
2145 Delaware Avenue
Santa Cruz, CA 95060
800.457.3801 or 831.457.3800
Emergency:
ChemWatch
Within the US & Canada: 877-715-9305
Outside the US & Canada: +800 2436 2255
(1-800-CHEMCALL) or call +613 9573 3112
Section 2 - Hazardous Ingredients/Identity Information
HMIS ClassificationHealth Hazard: 1: Chronic Health Hazard: *: Flammability: 0 :Physical hazards: 0
Section 3 - Physical/Chemical Characteristics
Boiling Point:
N/A
Apearance and Odor:
White Powder
Vapor Pressure:
N/A
Specific Gravity(H2O=1):
N/A
Solubility in Water:
N/A
Melting Point:
133-136º C
Evaporation Rate (ButylAcetate=1):
N/A
Vapor Density:
N/A
Section 4 - Reactive Data
Stability:
STABLE
Incompatability (Materials to Avoid):
Alkali metals, Aluminum, Strong oxidizing agents
Conditions to Avoid:
Strong oxidizers, Heat
Hazardous Decomposition or Byproducts:
CARBON MONOXIDE, CARBON DIOXIDE, NITROGEN OXIDES
Hazardous Polymerization:
WILL NOT OCCUR
Section 5 - Control Measures
Respiratory Protection:
Niosh/Msha approved respirator
Ventilation:
HOOD
Protective Gloves:
RUBBER GLOVES
Eye Protection:
SAFETY GOGGLES
Other Protective Clothing:
LAB COAT/APRON
Other Protection:
SAFETY EYE WASH
Section 6 - First Aid Measures
Inhalation:
IF INHALED, REMOVE TO FRESH AIR. IF BREATHING BECOMES DIFFICULT, CALL A PHYSICIAN.
Skin:
IN CASE OF SKIN CONTACT, FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15
MINUTES. REMOVE CONTAMINATED CLOTHING AND SHOES.
Ingestion:
IN SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS. CALL A
PHYSICIAN.
Eyes:
IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15
MIN.. ASSURE ADEQUATE FLUSHING BY SEPARATING EYELIDS.
Section 7 - Health Hazard Data
Health Hazards (Acute and Chronic):
ROUTE OF EXPOSURE Skin Contact: May cause skin irritation. Skin Absorption: May be harmful if
absorbed through the skin. Eye Contact: May cause eye irritation. Inhalation: May be harmful if inhaled.
Material may be irritating to mucous membranes and upper respiratory tract. Ingestion: May be
harmful if swallowed. TARGET ORGAN(S) OR SYSTEM(S) Immune system. Kidneys. Liver. Blood. SIGNS
AND SYMPTOMS OF EXPOSURE Cyclosporin A is a powerful immunosuppressant. Exposure may be
associated with the development of lymphomas. Other symptoms of exposure may include hirsutism,
rashes, gum hypertrophy, angio-oedema, mild tremor, and hypertension. Absorption into the body
leads to the formation of methemoglobin which in sufficient concentration causes cyanosis. Onset may
be delayed 2 to 4 hours or longer. Exposure can cause: Headache. Nausea. Vomiting. Tremors.
Diarrhea. Exposure may cause a rise in blood pressure. To the best of our knowledge, the chemical,
physical, and the toxicological properties have not been thoroughly investigated. TOXICITY DATA Oral
Rat 1480 mg/kg LD50 Remarks: Behavioral:Muscle contraction or spasticity.
Gastrointestinal:Hypermotility, diarrhea. Skin and Appendages: Other: Hair. Intraperitoneal Rat 147
MG/KG LD50 Subcutaneous Rat 286 MG/KG LD50 Intravenous Rat 24 MG/KG LD50 Oral Mouse 2329
mg/kg LD50 Remarks: Behavioral:Muscle contraction or spasticity. Gastrointestinal:Hypermotility,
diarrhea. Skin and Appendages: Other: Hair. Intravenous Mouse 96 MG/KG LD50 Oral Rabbit > 1000
mg/kg LD50 Remarks: Behavioral:Muscle contraction or spasticity. Gastrointestinal:Hypermotility,
diarrhea. Skin and Appendages: Other: Hair. Intravenous Rabbit 10 MG/KG LD50 CHRONIC EXPOSURE
- CARCINOGEN Species: Man Route of Application: Oral Dose: 259 MG/KG Exposure Time: 2W
Frequency: C Result: Tumorigenic:Carcinogenic by RTECS criteria. Blood:Lymphomas including
Hodgkin's disease. IARC CARCINOGEN LIST Rating: Group 1 NTP CARCINOGEN LIST Rating: Known to
be carcinogenic. CHRONIC EXPOSURE - TERATOGEN Result: Laboratory experiments have shown
teratogenic effects. CHRONIC EXPOSURE - MUTAGEN Species: Human Dose: 50 MG/L Cell Type:
lymphocyte Mutation test: Other mutation test systems Species: Human Dose: 1 MG/L Cell Type:
lymphocyte Mutation test: Sister chromatid exchange CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: May cause reproductive disorders. Species: Rat Dose: 166 MG/KG Route of Application:
Subcutaneous Exposure Time: (45D MALE) Result: Paternal Effects: Spermatogenesis (including
genetic material, sperm morphology,motility, and count) Paternal Effects: Other effects on male.
Effects on Fertility: Male fertility index (e.g., # males impregnating females per # males exposed to
fertile nonpregnant females). Species: Rat Dose: 420 MG/KG Route of Application: Subcutaneous
Exposure Time: (14D MALE) Result: Paternal Effects: Spermatogenesis (including genetic material,
sperm morphology,motility, and count) Species: Rat Dose: 560 MG/KG Route of Application:
Subcutaneous Exposure Time: (14D MALE) Result:Paternal Effects: Spermatogenesis (including
genetic material, sperm morphology,motility, and count) Paternal Effects: Testes, epididymis, sperm
duct. Paternal Effects: Other effects on male. Species: Mouse Dose: 90 MG/KG Route of Application:
Intraperitoneal Exposure Time: (6-8D PREG) Result: Effects on Fertility: Post-implantation mortality
(e.g., dead and/or resorbed implants per total number of implants). Effects on Embryo or Fetus: Fetal
death. Species: Mouse Dose: 50 MG/KG Route of Application: Intraperitoneal Exposure Time: (12D
PREG) Result: Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per
total number of implants). Specific Developmental Abnormalities: Craniofacial (including nose and
tongue). Species: Rabbit Dose: 210 MG/KG Route of Application: Intramuscular Exposure Time: (14D
PRE) Result: Maternal Effects: Ovaries, fallopian tubes. Effects on Fertility: Other measures of fertility
Medical Conditions Generally Aggravated by Exposure:
To the best of our knowledge the chemical, physical, and toxicological properties have not been
thoroughly investigated. Exercise due care.
Section 8 - Precautions for Safe Handling and Use
Steps to be Taken in Case Material is Released or Spilled:
WEAR PROTECTIVE EQUIPMENT. SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
AVOID RAISING DUST. VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS
COMPLETE.
Waste Disposal Method:
DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A CHEMICAL
INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE
AND LOCAL ENVIRONMENTAL REGULATIONS.
Precautions to Be Taken in Handling and Storage:
MECHANICAL EXHAUST REQUIRED. DO NOT BREATH DUST. AVOID CONTACT WITH EYES, SKIN AND
CLOTHING. KEEP TIGHTLY CLOSED. STORE IN A COOL DRY PLACE.
Section 9 - Fire and Explosion Hazard Data
Extinguishing Media:
WATER SPRAY. CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
Special Fire Fighting Procedures:
WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO PREVENT
CONTACT WITH SKIN AND EYES.
Unusual Fire and Explosion Hazards:
Emits Toxic Fumes under Fire Conditions.
Section 10 - Transportation Information and regulatory information
DOT
Proper Shipping Name: None Non-Hazardous for Transport: This substance is considered to be nonhazardous for transport.
IATA
Non-Hazardous for Air Transport: Non-hazardous for air transport.
The above information is believed to be correct but does not purport to be complete and
should be used only as a guide. The burden of safe use of this material rests entirely with the
user.
6/25/2010