ÖZGEÇMİŞ VE ESERLER LİSTESİ
ÖZGEÇMİŞ
Adı Soyadı: Ahmet Okay ÇAĞLAYAN
Öğrenim Durumu:
Derece
Bölüm/Program
Üniversite
Yıl
Y. Lisans
Tıp Fakültesi
Osmangazi Üniversitesi, Tıp
Fakültesi
2001
Doktora/S.Yeterlik/
Tıpta Uzmanlık
Tıbbi Genetik
Erciyes Üniversitesi,
Fakültesi
2007
Docentlik
Tıbbi Genetik
Tıp
2012
Görevler:
Görev Unvanı
Görev Yeri
Yıl
Dr. Ar. Gör.
Erciyes Üniversitesi, Tıp Fakültesi
2003-2007
Uz. Dr.
Kayseri Eğitim ve Araştırma Hastanesi
2008-2013
Doktora Sonrası
Arastırmacı Dr.
Yale Üniversitesi
2010-2011
Öğretim Görevlisi
Yale Üniversitesi
2012-2015
Doç. Dr.
İstanbul Bilim Üniversitesi
2015-
Bilimsel Kuruluşlara Üyelikler :
2015 – American Association for Science and Technology
2008 – European Biotechnology Thematic Network Association
2007 – Türkiye Diabet, Obezite ve Beslenme Derneği
2006 – Tıbbi Genetik Derneği
Editöryal Hizmetler
2014- Halen Editorial Board, Austin Journal of Autism and Related Disorders
2014- Halen Editorial Board, Austin Journal of Clinical Neurology
2012- Halen Editorial Board, Journal of Genomes and Exomes
2010- Halen Associate Editor, Frontiers in Child and Neurodevelopmental Psychiatry
2009- 2014
Assistant Editor, Journal of Pediatric Neurology
2009- 2010
Co-Editor, Türkiye Tıbbi Genetik Derneği Bülteni
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ARAŞTIRMA MAKALELERİ (SCI DERGİLERDE)
Dundar, M., O. Caglayan, C. Saatci, H. Karaca, M. Baskol, S. Tahiri, Y. Ozkul, “How the I1307K
Adenomatous Polyposis Coli Gene Variant Contributes in the Assessment of Risk of
Colorectal Cancer, but not Stomach Cancer, in a Turkish Population”, Cancer Genet.
Cytogenet., 2007;177: 95-97.
Eggermann, T., E. Meyer, O. Caglayan, M. Dundar, N. Schönherr, “ICR1 epimutations in
11p15 are restricted to patients with Silver-Russell syndrome features”, J. Pediatr.
Endocrinol. Metab., 2008;21: 59-62.
Saatci, C, Y. Ozkul, S. Tahiri, A.O. Caglayan, A.B. Turhan, M. Dundar, “The effect of maras
powder on DNA methylation and micronucleus formation in human buccal tissue”, J.
Toxicol. Environ. Health. A., 2008;71: 396-404.
Unger, S., F. Antoniazzi, M. Brugnara, Y. Alanay, A. Caglayan, K. Lachlan, S. Ikegawa, G.
Nishimura, B. Zabel, J. Spranger, A. Superti-Furga, “Clinical and radiographic delineation of
odontochondrodysplasia”, Am. J. Med. Genet. A., 2008;146: 770-778.
Dundar, M., K. Erkilic, M. Agun, A.O. Caglayan, P. Comeglio, G. Matyas, A.H. Child, “Scoliosis,
blindness and arachnodactyly in a large Turkish Family: Is it new syndrome?”, Genet. Couns.,
2008;19: 319-330.
Tanriverdi, F., S. Taheri, H. Ulutabanca, A.O. Caglayan, Y. Ozkul, M. Dundar, A. Selcuklu, K.
Unluhizarci, F.F. Casanueva, F. Kelestimur, “Apolipoprotein E3/E3 genotype decreases the
risk of pituitary dysfunction after traumatic brain injury due to various causes: preliminary
data”, J. Neurotrauma, 2008;25: 1071-1077
Yalcin, A.A., N. Kalay, A.O. Caglayan, F. Kayaalti, M. Duran, I. Ozdogru, M.T. Inanc, A. Dogan,
E. Basar, A. Oguzhan, “The Relationship between Slow Coronary Flow and Angiotensin
Converting Enzyme and ATIIR1 Gene Polymorphisms”, J. Natl. Med. Assoc., 2009;101: 40-45
Saatci, C., A.O. Caglayan, Y. Ozkul, S. Tahiri, A.B. Turhan, M. Dundar, “Detection of p16
promotor hypermethylation in "Maras powder" and tobacco users”, Cancer Epidemiology,
2009;33: 47-50
Caglayan, O., N. Kalay, C. Saatci, A. Yalcın, H. Akalın, M. Dundar, “Lack of Association of the
Glu298Asp Polymorphism of Endothelial Nitric Oxide Synthase with Coronary Slow Flow in
the Turkish Population”, Canadian J. Cardiology, 2009;25: e69-72.
Kalay, N., A.O. Caglayan, H. Akkaya, I. Ozdogru, A. Dogan, M.T. Inanc, M.G. Kaya, A. Ergin, R.
Topsakal, N.K. Eryol, A. Oguzhan, M.Dundar, “The Relation Between The Acute Aortic
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dissection and The Angiotensin Converting Enzyme Gene Polymorphism”, The Tohoku
Journal of Experimental Medicine, 2009;219: 33-37.
Saatci, C., A.O. Caglayan, I. Kocyigit, H. Akalin, L.G. Kaynar, F. Altuntas, B. Eser, M. Demir, M.
Cetin, Y. Ozkul, “No Significant Expression of WT1 Gene In Multiple Myeloma Patients At
Diagnosis: Is WT1 Gene Expression Useful Marker In Multiple Myeloma?”, Hematology,
2010;15(1): 39-42
Caglayan, A.O., I. Ozyazgan, F. Demiryilmaz, M.T. Ozgun, “Are Heterochromatin
Polymorphisms Affect Recurrent Miscarriage?: Cytogenetic Results of 336 Patients With
Recurrent Spontaneous Abortions in Middle Anatolia in Turkey”, Journal of Obstetrics and
Gynecology Research, 2010;36(4):774-776
Caglayan, A.O., I. Ozyazgan, F. Demiryilmaz, H. Gumus, “MEFV Gene Compound
Heterozygous Mutations In Familial Mediterranean Fever Phenotype: A Retrospective
Clinical and Molecular Study”, Nephrology Dialysis Transplantation, 2010;25(8): 2520-2523.
Bahi-Buisson, N., Poirier, K., Boddaert, N., Fallet-Bianco, C., Specchio, N.,
Bertini, E.,
Caglayan, O., Lascelles, K., Elie, C., Rambaud, J., Baulac, M., An, I., Dias, P., des Portes, V.,
Moutard, M.L., Soufflet, C., El Maleh, M., Beldjord, C., Villard, L., Chelly, J. “GPR56-related
bilateral frontoparietal polymicrogyria: further evidence for an overlap with the cobblestone
complex.”, Brain, 2010;133(11): 3194-3209.
Bilgüvar, K., Oztürk, A.K., Louvi, A., Kwan, K.Y., Choi, M., Tatli, B., Yalnizoğlu, D., Tüysüz, B.,
Cağlayan, A.O., Gökben, S., Kaymakçalan, H., Barak, T., Bakircioğlu, M., Yasuno, K., Ho, W.,
Sanders, S., Zhu, Y., Yilmaz, S., Dinçer, A., Johnson, M.H., Bronen, R.A., Koçer, N., Per, H.,
Mane, S., Pamir, M.N., Yalçinkaya, C., Kumandaş, S., Topçu, M., Ozmen, M., Sestan, N.,
Lifton, R.P., State, M.W., Günel, M. “Whole-exome sequencing identifies recessive WDR62
mutations in severe brain malformations.”, Nature, 2010;467(7312): 207-210.
Bakircioglu, M., O.P. Carvalho, M. Khurshid, J.J. Cox, B. Tuysuz, T. Barak, S. Yilmaz, O.
Caglayan, A. Dincer, A.K. Nicholas, O. Quarrell, K. Springell, G. Karbani, S. Malik, C. Gannon,
E. Sheridan, M. Crosier, S.N. Lisgo, S. Lindsay, K. Bilguvar, F. Gergely, M. Gunel, C.G. Woods,
“The Essential Role of Centrosomal NDE1 in Human Cerebral Cortex Neurogenesis”, Am. J.
Hum. Genet., 2011;88(5): 523-535.
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Caglayan, A.O, M. Dundar, F. Tanriverdi, N. A. Baysal, K. Unluhizarci, Y. Ozkul, M. Borlu, C.
Batukan, F. Kelestimur, “Can Decreased Aromatase and 5-alpha reductase expressions can
be responsible for idiopathic hirsutism?”, Fertil. Steril. 2011;96(2): 479-482.
Barak, T., K.Y. Kwan, A. Louvi, V. Demirbilek, S. Saygı, B. Tüysüz, M. Choi, H. Boyacı, K.
Doerschner, Y. Zhu, H. Kaymakçalan, S. Yılmaz, M. Bakırcıoğlu, A.O. Cağlayan, A.K. Oztürk, K.
Yasuno, W.J. Brunken, E. Atalar, C. Yalçınkaya, A. Dinçer, R.A. Bronen, S. Mane, T. Ozçelik,
R.P. Lifton, N. Sestan, K. Bilgüvar, M. Günel, “Recessive LAMC3 mutations cause
malformations of occipital cortical development”, Nat. Genet., 2011;43(6): 590-594.
Kalb, S., A.O. Caglayan, A. Degerliyurt, S. Schmid, S. Ceylaner, G. Utermann, N. Hatipoglu, K.
Hinderhofer, H. Rehder, S. Kurtoglu, G. Ceylaner, J. Zschocke, M. Witsch-Baumgartner,” High
Frequency of p.Thr93Met in Smith-Lemli-Opitz Syndrome Patients in Turkey”, Clin. Genet.,
2012;81(6): 598-601.
Bilguvar, K., N.K. Tyagi, C. Ozkara, B. Tuysuz, M. Bakircioglu, M. Choi, S. Delil, A.O. Caglayan,
J.F. Baranoski, O. Erturk, C. Yalcinkaya, M. Karacorlu, A. Dincer, M.H. Johnson, S. Mane, S.S.
Chandra, A. Louvi, T.J. Boggon, R.P. Lifton, A.L. Horwich, M. Gunel. “Recessive loss of
function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive
neurodegeneration”, PNAS, 2013;110(9): 3489-3494.
Clark, V.E., E.Z. Erson-Omay, A. Serin, J. Yin, J. Cotney, K. Ozduman, T. Avşar J. Li, P.B.
Murray, O. Henegariu, S. Yilmaz, J.M. Günel, G. Carrión-Grant, B. Yilmaz, C. Grady, B.
Tanrikulu, M. Bakircioğlu, H. Kaymakçalan, A.O. Caglayan, L. Sencar, E. Ceyhun, A.F. Atik, Y.
Bayri, H. Bai, L.E. Kolb, R.M. Hebert, S.B. Omay, K. Mishra-Gorur, M. Choi, J.D. Overton, E.C.
Holland, S. Mane, M.W. State, K. Bilgüvar, J.M. Baehring, P.H. Gutin, J.M. Piepmeier, A.
Vortmeyer, C.W. Brennan, M.N. Pamir, T. Kiliç, R.P. Lifton, J.P. Noonan, K. Yasuno, M. Günel.
“Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and
SMO”, Science, 2013;339(6123): 1077-1080.
Radmanesh, F.,* Caglayan A.O.,* L.J. Silhavy, C. Yilmaz, V. Cantagrel, T. Omar, B. Rosti, H.
Kaymakcalan, S. Gabriel, M. Li, N. Šestan, K. Bilguvar, W.B. Dobyns, M.S. Zaki, M. Gunel, J.G.
Gleeson, “Mutations in LAMB1 Cause Cobblestone Brain Malformation without Muscular or
Ocular Abnormalities”, Am. J. Hum. Genet., 2013;92(3): 468-474.
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Novarino, G., Fenstermaker, A.G., Zaki, M.S., Hofree, M., Silhavy, J.L., Heiberg, A.D.,
Abdellateef, M., Rosti, B., Scott, E., Mansour, L., Masri, A., Kayserili, H., Al-Aama, J.Y., AbdelSalam, G.M., Karminejad, A., Kara, M., Kara, B., Bozorgmehri, B., Ben-Omran, T., Mojahedi,
F., Mahmoud, I.G., Bouslam, N., Bouhouche, A., Benomar, A., Hanein, S., Raymond, L.,
Forlani, S., Mascaro, M., Selim, L., Shehata, N., Al-Allawi, N., Bindu, P.S., Azam, M., Gunel,
M., Caglayan, A., Bilguvar, K., Tolun, A., Issa, M.Y., Schroth, J., Spencer, E.G., Rosti, R.O.,
Akizu, N., Vaux, K.K., Johansen, A., Koh, A.A., Megahed, H., Durr, A., Brice, A., Stevanin, G.,
Gabriel, S.B., Ideker, T., Gleeson, J.G., “Exome sequencing links corticospinal motor neuron
disease to common neurodegenerative disorders.”, Science, 2014;343(6170): 506-511.
Schaffer, A.E., Eggens, V.R., Caglayan, A.O., Reuter, M.S., Scott, E., Coufal, N.G., Silhavy, J.L.,
Xue, Y., Kayserili, H., Yasuno, K., Rostim R,O,, Abdellateef, M., Caglar, C., Kasher, P.R.,
Cazemier, J.L., Weterman, M.A., Cantagrel, V., Cai, N., Zweier, C., Altunoglu, U., Satkin, N.B.,
Aktar, F., Tuysuz, B., Yalcinkaya, C., Caksen, H., Bilguvar, K., Fu, X.D., Trotta, C.R., Gabriel, S.,
Reis, A., Gunel, M., Baas, F., Gleeson, J.G., “CLP1 Founder Mutation Links tRNA Splicing and
Maturation to Cerebellar Development and Neurodegeneration.”, Cell, 2014;157(3): 651663.
Tüysüz, B., K. Bilguvar, N. Koçer, C. Yalçınkaya, O. Cağlayan, E. Gül, S. Sahin, S. Comu, M.
Günel. “Autosomal recessive spastic tetraplegia caused by AP4M1 and AP4B1 gene
mutation: Expansion of the facial and neuroimaging features”, Am J Med Genet A.,
2014;164(7): 1677-1685.
Caglayan, A.O., J.F. Baranoski, F. Aktar., W. Han, B. Tuysuz, A. Guzel, B. Guclu, H.
Kaymakcalan, B. Aktekin, G.T. Akgumus, P.B. Murray, E.Z. Erson-Omay, C. Caglar, M.
Bakircioglu, Y.B. Sakalar, E. Guzel, N. Demir, O. Tuncer, S. Senturk, B. Ekici, F.J. Minja, N.
Šestan, K. Yasuno, K. Bilguvar, H. Caksen, M. Gunel. “Brain Malformations Associated with
Knobloch Syndrome – Review of Literature, Expanding Clinical Spectrum and Identification
of Novel Mutations”, Pediatric Neurology, 2014;51(6): 806-813.e8.
Mishra-Gorur K.,* Caglayan, A.O.,* A.E. Schaffer, C. Chabu, O. Henegariu, F. Vonhoff, G.T.
Akgümüş, S. Nishimura, W. Han, S. Tu, B. Baran, H. Gümüş, C. Dilber, M.S. Zaki, H.A.A.
Hossni, J-B Rivière, H. Kayserili, E.G. Spencer, R.Ö. Rosti, J. Schroth, H. Per, C. Çağlar, Ç.
Çağlar, D. Dölen, J.F. Baranoski, S. Kumandaş, F.J. Minja, E.Z. Erson-Omay, S.M. Mane, R.P.
Lifton, T. Xu, H. Keshishian, W.B. Dobyns, N.C. Chi, N. Šestan, A. Louvi, K. Bilgüvar, K. Yasuno,
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J.G. Gleeson, M. Günel. Mutations in KATNB1 Cause Complex Cerebral Malformations by
Disrupting Asymmetrically Dividing Neural Progenitors. 2014;84(6): 1226–1239.
Erson-Omay E.Z.,* Caglayan, A.O.,* N. Schultz, N. Weinhold, S.B. Omay, K. Ozduman, Y.
Koksal, J. Li, A.S. Harmancı, V. Clark, G. Carrio´n-Grant, J. Baranoski, C. Caglar, T. Barak, S.
Coskun, B. Baran, D. Kose, J. Sun, M. Bakırcıog lu, J.M. Gunel, M.N. Pamir, K. Mishra-Gorur,
K. Bilguvar, K. Yasuno, A. Vortmeyer, A.J. Huttner, C. Sander, M. Gunel. Somatic POLE
mutations cause an ultramutated giant cell high-grade glioma subtype with better
prognosis. Neuro-Oncology 2015; 0, 1–9, doi:10.1093/neuonc/nov027
*Co-first authorship
KİTAP BÖLÜMLERİ
Dundar, M. ve A.O. Çağlayan, Andreoli and Carpenter’s Cecil Essentials of Medicine, ed.
C.C.J. Carpenter, R.C. Griggs and I.J. Benjamin, 7th Edition, 2-15, Nobel Tıp, İstanbul, 2007
(Translation).
Dündar, M. ve A. O. Çağlayan, Lomber Dejeneratif Disk Hastalığı, ed. R.K. Koç, Türk
Neroşirürji Derneği Spinal ve Periferik Sinir Cerrahisi Grubu Yayınları No:8, Buluş Tasarım ve
Matbaacılık, 16-28, Ankara, 2008 (Chapter of the book).
Şanlıoğlu, S. ve A.O. Çağlayan, “Gen Tedavisi”, ed. M. Dündar, H. Bağış, Erciyes Üniversitesi
Yayınları No:180, 631-644, Kayseri, 2010 (Chapter of the book).
Çağlayan, A.O., J.F. Baranoski, A. Arzeno, “Dysmorphology and Databases”, Atlas of
Dysmorphology and Diagnosis, ed. Munis Dundar, Erciyes University Publications No:197,
499-510, Kayseri, 2015 (Chapter of the book).
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