3/24/2015 1 Lower Extremity Strength and Cardiovascular Training in the Post-Stroke Population: Interpreting and Applying the Evidence Melanie Lomaglio, PT, MSc., NCS [email protected] Lindsay Perry, PT, DPT, NCS [email protected] 2 Course Objectives: Differentiate between the terms: muscle strength, muscle force, joint torque, and muscle power Differentiate between mechanical and neurological components of normal and abnormal muscle force generation Review the length tension relationship and force velocity curves and relate them to joint torque and the post stroke population Understand the influence of strength training on spasticity Explain the relationship between muscle strength and function for both healthy adults and post stroke adults 3 Course Objectives Understand maximal, submaximal exercise testing, and the alternative objective measures of the cardiovascular system (i.e. VO2 peak, 6 minute walk test) Explore various treatment options to improve strength and cardiovascular function Explore the relationships between cardiovascular fitness, quality of life, and functional mobility Prescribe an appropriate muscle strengthening and aerobic exercise program for an individual post stroke 4 Course Outline Introduction Provide a rational for our topic selection Part I: Strength Training Mechanisms of force production and post stroke weakness AHA/ASH, ACSM and CDC recommendations Practical treatment ideas for various modes of strength training Clinical cases/Discussion Part II: Cardiovascular Training Differentiate between Physical Activity and Exercise Assessment of the Cardiorespiratory system Identify challenges of implementing an aerobic program Review the evidence supporting aerobic training guidelines for patients post stroke Discuss Clinical Case 5 Rational for session 1 3/24/2015 There is strong evidence to recommend low to moderate intensity aerobic activity, muscle strengthening, and a reduction of sedentary behavior for post stroke care (Billinger et al., 2014) Aerobic and resistance exercise is currently underutilized in post-stroke care Let’s make a change 6 Muscle Strength DOES STRENGTH = MUSCLE FORCE? Muscle force is extremely difficult to measure: 7 Muscle Strength Lieber: STRENGTH = JOINT TORQUE = Muscle Force (N) x Moment Arm (m) 8 Muscle Force Mechanical Properties Cross sectional area Muscle Fiber type Length tension relationship Force-Velocity relationship Neurological Properties Central Motor Drive Rate coding 9 Length-tension Relationship: predicts the amount of force generated 10 Force-velocity relationship 11 Weakness Following Stroke: HISTORICALLY: Weakness overlooked by clinician Strength training not believed to be effective in people with brain damage High effort and resistance training thought to worsen spasticity (Bobath: 1990) 2 3/24/2015 12 Weakness Following Stroke TODAY: Weakness is recognized as a primary impairment Strength and functional performance are strongly correlated (Kim and Eng 2003, Lomaglio and Eng 2004, Ng and Hui-Chan 2012, Dorsch et al. 2012, Patten et al. 2013) Strength training is effective (Morris et al. 2004, Pak and Patten 2008, Billinger 2014) Resistance training does NOT worsen spasticity (Morris et al., 2004, Patten et al. 2004, Ada et al. 2006, Pak and Patten 2008, Flansbjer et al. 2008) 13 Weakness Following Stroke Impaired central motor drive Reduced firing rates and impaired rate coding Compensate with additional motor unit recruitment Abnormal Co-contraction of antagonist Active restraint to agonist force production Narrowed firing thresholds Slower speed of contraction (54 % slower) Type II fiber atrophy Evidence of bilateral weakness (“less affected” side) 14 Weakness Following Stroke Shorter and stiffer muscle fibers Reduced sarcomeres in series, infiltration of connective tissue Passive restraint to the agonist Relative preservation of eccentric torque occurs bilaterally (Eng et al., 2009) Concentric torque-velocity curve altered With increasing speed, paretic limb torque decreases at a greater rate than the nonparetic side 40-60% for paretic UE vs 10-15% for nonparetic as speed increased from 30-120 deg/s (Patten 2004) Isometric torque-angle curve altered Exaggerated weakness at short muscle lengths with relative preservation at long lengths 15 Torque-angle curve in the paretic knee extensors 16 Descriptive Research Suggests Passive stretching to prevent stiffness Prevent atrophy via strength training Strengthen paretic muscles over short lengths 3 3/24/2015 Harness eccentric strength preservation More efficient and higher force production Incorporate exercises that increase speed of contraction for power Incorporate exercises that work on slow contractions to increase force Address the non-paretic limb to prevent weakness and to promote cross education 17 American College of Sports Medicine (ACSM) Scientific Recommendations for Sedentary Older Adult (Garber et al. 2011) 1 set of 10-15 reps of each major ms group 40-50% of 1RM (very light to light intensity) 2-3 d/week Rest ≥48hrs Gradual progression to: 2-4 sets Rest 2-3mins between 60-70% of 1RM for novice to intermediate ≥ 80% of 1RM for experienced < 50% 1 RM and 15-20 reps for endurance 18 American Heart and Stroke Association (AHA/ASA) Scientific Recommendations for Stroke Survivors (Billinger et al., 2014) At least 1 set of 10-15 reps of 8-10 exercises (torso, upper and lower extremities) 50-80% of 1 RM 2-3 days/week Progress to 2-3 sets Note: There are no specific protocols to guide physical activity prescription in the first 48 hours post stroke but muscular strength and endurance is recommended for in-patient rehabilitation and out-patient settings once the patient is medically stable Exercise programs should be developed by trained exercise professionals and should be offered early after stroke 19 Centers for Disease Control & Prevention (CDC): older adult recommendations: supervised not ≥ 2 days/week ≥ 1 set of 8-12 reps (more benefit with 2-3 sets) Rest 2-3 min between sets Begin with no weight and re-assess bi-weekly If you can lift the wt >12 times with good form it’s time to increase weight 4 3/24/2015 If you can’t do ≥8 reps then you should reduce the weight Work all major muscle groups (program online) Legs, hips, back, chest, abdomen, shoulders, and arms W/u 5-10mins Cool down with stretching (30-60s for older adult) 20 Pre-Screening Important Complete medical history Assess strength, balance, cognition, behavior, communication Medical Clearance Physical Readiness Questionnaire (PAR-Q) Obtain medical clearance for patients with cardiac co-morbidities Assess vitals Assess BP before Supine, sitting, standing 21 Calculating 1 RM indirectly with submax estimation online calculator 22 Calculating by hand with coefficients 23 Estimating 1RM based on 10RM (may take some trial and error) 10 reps to fatigue (can do NO more) ≈ 75% of the 1 RM (Brzycki 1998) If patient can perform 10 reps (and NO more) of knee extension with 7 lbs we can determine his 1 RM 1 RM = 7 lbs/.75 1RM = wt lifted/%1RM 1 RM = 9 lbs Now you can select whatever % is appropriate for training 24 Successful and Safe PRT protocols from the RCT literature 1 Ouellette et al., 2004: Chronic stroke 3x/week for 12 weeks, Keiser pneumatic leg press, knee and ankle flex and ext Warm up: 1 set of 4 reps at 25% 1RM 3 sets of 8 to 10 reps at 70% 1RM Intensity increased bi-weekly by determining the 1RM 2 Flansbjer et al., 2008: Chronic stroke 2x/week for 10 weeks, pneumatic device, knee flex and ext Warm up: 5mins on bike, 1 set of 5 reps 0 weight 1set of 5 reps at 25% 2 sets of 6-8 reps at 80% 1 RM 2 min rest between 5 3/24/2015 Intensity increased bi-weekly Stretching to cool down 25 Eccentric only training: No superior benefit over other training modes have been demonstrated yet but carry over to function looks promising (Fernandez-Gonzalo et al., 2014, Clark and Patten 2012) Potent training stimulus More efficient Relative preservation (train at higher loads) Research is limited 26 Power Training: Concentric phase as quick as possible/Eccentric phase controlled over 2-4 sec Fall prevention Alerted torque-velocity curve Promising in the paretic UE (Patten et al. 2013) and older adult for improving functional performance (Sayers 2007) Start at a lower intensity and progress (Puthoff CSM 2015) Must develop a base first, then increase speed 8-12 reps, 1-3 sets 20-40% of 1RM to start, increase to 60-70% 1 RM Weight bearing / function based exercise, shuttle, and pneumantic Keiser devices Weighted vests (start at 2% of body weight and add 1-2% as able) and theraband 27 Functional Training: Repeated standing up and sitting down Lower seat height Bias weaker extremity +/- use of UE’s for different phases of movement Step ups/downs/ lateral Raise step height Heel raises Lunges Squats/mini squats Walking against resistance Part task practice Ex: trailing leg position with theraband 28 Functional Training Cook et al. 2014 Limited research on functional progressive repetitive training Cook et al. (2014) compared 102 acute post stroke patients on: 6 3/24/2015 CPT vs CPT+FST vs CPT+CPT Both extra therapy groups (1+hr) showed greater improvement in gait speed compared to the control No group differences for strength SAMPLE FST: 5 reps of STS from 40 ◦ Once 5 sets of 10 achieved, ht was lowered Progressed to 5 sets of 10 from 120◦ Stair climbing similar protocol Other activities included transfer training, gait and BWSTT 29 Cross-Education Training Clark and Patten (2012) reported a significant transfer effect to nonparetic untrained LE after both concentric (12%) and eccentric (14%) isokinetic power training of the paretic LE Gragert and Zehr (2013) reported a 31% increase in torque in the paretic untrained dorsiflexors and a 35% in the nonparetic trained dorsiflexors after isometric training with no significant difference in the amount of increase Implications for the severely weak 30 RISKS of Progressive Resistance Training (PRT) Morris et al (2004) systematic review of PRT reported no major adverse events (N = 201) 2 subjects reported musculoskeletal pain in knee and back No missed sessions and no analgesia needed Burr et al. (2012) “Adverse events during resistance training are nearly non-existent” Falls Valsalva / transient HTN Delayed onset muscle soreness (DOMS) 31 Other considerations: Strength training in the very weak (<3/5) Consider open-chain Consider eccentric training Electrical-stim with or without voluntary contraction Biofeedback Mental imagery 32 Do improvements in strength cause improvements in function? There is conflicting evidence that changes in strength result in improvements in ADL 7 3/24/2015 performance, distance walked or gait speed (refer to ebrsr.com for a review) Systematic reviews also conflict: Pak and Patten 2008: +ve strength, + function, + participation Ada et al 2006*: +ve strength, + function Morris et al 2004: +ve strength, –ve function *Ada et al., 2006 included studies with mental imagery, biofeedback and muscle re-education repetitive training 33 Possible explanations: Many studies examine isometric torque only Gait is complex Non-linear relationship between gait and function has been demonstrated in both healthy (Buchner et al. 1996) and post-stroke subjects (Carvalho et al. 2013) 34 Other considerations: Capacity and Capability via Multi-modal Exercise 1 Prevent atrophy and increase strength Increase physical fitness Reduce osteoporosis Reduce fatigue Decrease cardiovascular risk Increase mobility Reduce depression and social isolation 2 Strength, endurance, and possibly power training for fall prevention Aerobic Circuit Training Flexibility Neuromuscular (balance coordination) Functional training 35 Key References and Resources Position Statements: Billinger SA, Arena R, Bernhardt J et al. Physical Activity and Exercise Recommendations for Stroke Survivors. A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2014;45:2532-2553. 8 3/24/2015 Garber CE, Blissmer B, Deschenes MR, et al. Quantity and Quality of Exercise for Developing and Maintaining Cardiorespiratory, Musculoskeletal, and Neuromotor Fitness in Apparently Healthy Adults: Guidance for Prescribing Exercise. Med Sci Sports Exerc. 2011;43:1334-1359. http://www.cdc.gov/physicalactivity/everyone/guidelines/adults.html. accessed March 16, 2015. Critical and Systematic Reviews: Ada L, Dorsch S, Canning CG. Strengthening interventions increase strength and improve activity after stroke: a systematic review. 2006;52:241-248. Gray V, Rice C, Garland SJ. Factors that Influence Muscle Weakness Following Stroke and Their Clinical Implications: A Critical Review. Physiother Can. 2012;64;415-426. Morris SL, Dodd KJ, Morris ME. Outcomes of Progressive Resistance Strength Training Following Stroke: A systematic Review. Clin Rehabil. 2004;18:27-39. Pak, S and Patten, C. Strengthening to Promote functional recovery poststroke: An Evidence Based Review. Top Stroke Rehabil. 2008;15: 177-199. Evidenced-Based Review of Stroke Rehabilitation: www. ebrsr.com 36 Clinical Cases / Lab / Discussion 37 Cardiovascular (CV) Training They What, Why and How AKA… Exercise Training, Cardiorespiratory fitness, Aerobic Training, Physical Activity, Functional Training, Exercise Prescription 38 Risks for primary (and secondary) stroke Non Modifiable Factors Age, gender, genes Modifiable Behavior, sedentary lifestyle Health choices: smoking, food intake, exercise Higher stroke severity is strongly correlated with sedentary behavior Survivors of mild severity Stroke spend 81% of day sedentary 1 year post stroke (Tieges, et al 2014) Despite relatively good functional recovery Interrupted versus Total sedentary time 39 Effect of Stroke on the systems Increased risk for fatigue Chronic fatigue Exertional Fatigue Negative cycles created and reinforced: 9 3/24/2015 Motor impairments limit function, increase energy expenditure functional limitations limit activity sedentary lifestyle increases risk for fatigue fatigue limits desire to be physically active more fatigue generated and more impaired CV and strength systems Mental Health Increased risk of Depression Will impact compliance and motivation with an exercise program 40 Effects of Stroke on Muscle Composition Wasting Intramuscular fat Change from slow to fast twitch Inflammatory cytokines Reduced capillaries per muscle fiber 41 Effect of stroke on Cardiovascular System Increased levels of pro-inflammatory markers Abnormal glucose and insulin metabolism Impaired autonomic control Respiratory dysfunction 42 Adhering to Exercise: Limitations Self- efficacy Family involvement may play a key role (Galvin 2011) Behavior modification/change required Transtheoretical model (Prochaska, 1997) Do you consider not doing your exercise to be a problem? Are you bothered by not doing the exercise? Are you interested in doing the exercise? Are you prepared to do something to start doing the exercise? 43 Physical Fitness: A set of measurable health and skill related attributes including; ability to carry out daily activities without undue fatigue. Physical Activity Defined: “Any bodily movement produced by skeletal muscles that results in energy expenditure” *therapeutic activities* 10 3/24/2015 Exercise Defined: “A subset of physical activity that is structured, planned, and repetitive and has a final or intermediate objective for the improvement or maintenance of physical fitness”. Exercise is intentional. *therapeutic exercise* Physical Therapists are Movement Specialists: But do/should we define ourselves as Exercise Specialists? 44 Goals of Exercise Training Prevent secondary complications after acute stroke: Learned disuse Metabolic dysfunctions of the multiple organ systems Regain pre-stroke levels of activity as soon as possible Interventions for motor recovery should include strength and CV training (CPG DOD, 2010) Increase in submax exercise tolerance improves ADL function Lower energy cost during functional mobility Self-management: confidence, empowerment Physical activity counseling intervention plan (Joubert et al, 2009) 45 Task Specific Training of the CV system: Challenges Risk of a cardiovascular event, or second stroke Limited time in therapy: Priorities Mode of aerobic exercise Physical limitations Social Support Access to equipment Limited knowledge of therapist regarding: Testing capacity of cardiorespiratory fitness Implementing and progressing programs 46 Considerations of Risks of exercise training post Stroke Secondary Stroke? Myocardial Infarction? Muscular Injury? Limited evidence regarding sentinel events during exercise tolerance testing (Zehr, 2011) 75 % survivors have concomitant CV disease (Billinger 2014) 11 3/24/2015 47 48 Measuring CV capacity Exercise tolerance testing (ETT): (Zehr, et al) (Billinger et al 2014) Maximal Tolerance Testing Bruce Protocol: Treadmill Submaximal Tolerance Testing https://youtu.be/wZe9TJQVc1Q YMCA Protocol ETT Guides prescription of intensity as a function of Max HR (HRmax) or % of Heart Rate Reserve Low Moderate Vigorous 49 50 How do I measure my patient’s CV system/endurance? Resting Heart Rate (RHR): Karvonen Formula* Consider limiting factors of accurate assessment: Beta Blockers Blood pressure SpO2 2, 6 or 12 minute walk test Can correlate to Peak VO2 with low to moderate reliability (Courbon, 2006, Tang, 2006) MCID 6MWT: 50 meters in mixed population (Perera et al.) VO 2 Max/peak via metabolic cart Normal values needed for independent living: 15-18 mlkg.min-1 Measuring Effort BORG: 12 to 14 on the Borg Scale suggest a moderate level of intensity of physical activity (Ammann et al, 2014) 51 52 Heart Rate Calculations Heart Rate Reserve: Heart Rate Max (HRmax) – Resting Heart Rate (HRrest) Estimated Max Heart Rate: 220-age Predicted Max Heart Rate 206.9-(.67 x age) Estimated Max HR on Beta Blocker 164-(.7 x age) 12 3/24/2015 Targer Heart Rate (THR) HRrest + (%age of HRR) 53 Parameters of a CV exercise program Volume 500-1,000 METS per week Intensities Low Moderate Vigorous Frequency 3-5 days/week Duration per day 20 minutes, 30 minutes, 60 minutes (pending intensity) Multiple 10 minute bouts Steady State versus Interval Training 54 55 Calculating VO2 Max VO2 max (mL·kg(-1)·min(-1)) = 70.161 + (0.023 × 6MWT [m]) - (0.276 × weight [kg]) - (6.79 × sex, where m = 0, f = 1) - (0.193 × resting HR [beats per minute]) - (0.191 × age [y]). 6 minute walk as a predictor of VO2 Max 56 Exercise Intensity 57 Exercise Intensity 58 ACSM Cardiovascular Guidelines: Older Adult 30 minutes minimum of Moderate intensity, 5 days a week 20 minutes of vigorous intensity, 3 days a week 59 Prescription considerations Aerobic instensity: VO2, Heart Rate, BP Neuromuscular intensity: Speed, Watts, reps/time: Rate Intensity within this system promotes neuroplasticity Aerobic reflects NM intensity Hornby, 2011 Intensity leads to greater production of Brain Derived Neurotrophic Factors (BDNF) (Mang 2013) 60 Clinical Case/ Lab/ Discussion 61 Quick References Guide 13 3/24/2015 Position Statements: Billinger SA, Arena R, Bernhardt J et al. Physical Activity and Exercise Recommendations for Stroke Survivors. A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2014;45:2532-2553. Garber CE, Blissmer B, Deschenes MR, et al. Quantity and Quality of Exercise for Developing and Maintaining Cardiorespiratory, Musculoskeletal, and Neuromotor Fitness in Apparently Healthy Adults: Guidance for Prescribing Exercise. Med Sci Sports Exerc. 2011;43:1334-1359. http://www.cdc.gov/physicalactivity/everyone/guidelines/olderadults.html Critical Analysis/ Systematic Reviews AEROBICS Best Practice Recommendations: http://strokebestpractices.ca/wpcontent/uploads/2013/07/AEROBICS-FINAL-July-2013.pdf Amman et al. Application of exercise principles in subacute and Chronic Stroke survivors: a systematic review. BMC Neurology 2014: 14:167 14 FPTA Spring Conference 2015: Lower Extremity Strength and Cardiovascular Training in the Post-Stroke Population: Interpreting and Applying the Evidence CASE 1: A 65 year old male is referred to outpatient physical therapy 6 months post R MCA ischemic stroke. The patient reports that he has fallen twice in the last 3 months. The patient has a history of HTN but no other significant co-morbidities. The patient played golf prior to his stroke but he was not an avid exerciser. The physician has cleared him for vigorous exercise. Patient Goals: Reduce fall risk, improve walking speed and strength BP: sitting 135/87, Standing 133/85, HTN controlled with Atenolol Resting HR: 75bpm Gait: mod I with single point cane for household distances. Mod I with single point cane on level terrain, supervision / min A for curbs and uneven terrain. During swing phase, intermittent foot drag occurs with reduced knee flexion during early swing. During stance phase the knee remains in 20degrees of flexion from initial contact through mid stance. 10m walk test: 0.50m/s (limited community ambulation speed) 6min walk test: 395m (572m is norm for age) Fugl-Meyer Motor Function: UE 45/66 (moderate impairment), LE: 24/34 (mild impairment) Sample strength testing for determination of 1RM: During long arc knee extension with a 5 lb cuff weight on the more affected side the patient completed 6 reps with good form but is unable to complete the 7th. During unilateral leg press the patient can push 15 lbs on the more affected side 20 times and no more, and 50 lbs on the less affected side 16 times and no more. Functional strength testing: Sit to Stand from standard height chair with arm rests (45cm/18inches): accomplishes task without the use of UEs but with slow movement speed and genu recurvatum of more affected knee at termination. Patient is able to demonstrate a controlled decent with stand to sit. Pt can repeat this 19 times with good form but unable to complete a 20th rep. 5xSTS test: 12sec (indicates fall risk and further balance assessment is needed) Stair climbing: Patient requires UE assist to climb a full flight of stairs with non-reciprocal pattern, left knee wobble noted Functional squat (retrieve object from floor): decreased weight acceptance on more affected LE For the above case please answer the following two questions: For long arc knee extension and leg press determine the appropriate load, reps, and initial training parameters. Explain your progression plan: FPTA Spring Conference 2015: Lower Extremity Strength and Cardiovascular Training in the Post-Stroke Population: Interpreting and Applying the Evidence Based on the patient’s functional strength assessment, what other resistance training exercises would you include: Consider all training modes, training parameters, and a progression plan. Note a rational for your choices. CASE 2: A 66 year old female is 3 weeks status post Right ACA ischemic stroke and is being seen in an inpatient rehabilitation setting. The patient is medically stable. The patient has a history of HTN and previous MI 6 years prior. The patient completed a cardiac rehab program post MI. Patient Goals: stand and transfer independently, walk within the home, get stronger BP: sitting 125/82, Standing 118/77, HTN controlled with Lozol (Indapamide) Resting HR: 75bpm Gait: moderate assistance required for 130 feet. The patient can initiate swing but with decreased force production and assist needed to achieve initial contact. Pt has reduced knee flexion to 30 degrees during initial swing. Stance phase requires stability assist at both the knee and hip to control against the effects of gravity. BERG: 28/56 (high fall risk) Fugl-Meyer Motor Function: UE 35/66 (moderate impairment), LE: 15/34 (moderate to severe impairment, able to flex knee and ankle in sitting) Functional strength testing: Sit to Stand from standard height chair with arm rests (45cm/18inches): patient accomplishes task with contact guard to min assist with heavy reliance of the less affected UE and LE throughout the execution phase. The patient is able to demonstrate a controlled decent with stand to sit but with asymmetrical limb loading and use of the less affected UE. The patient is unable to complete a 6th repetition without physical lifting assistance. Stair climbing: Patient requires UE assist for climbing a 6” step with the more affected LE. Patient is able to repeat this 4 times with good form and no more. For the above two functional exercises determine the appropriate load, reps and initial training parameters. Explain your progression plan: What other strengthening exercises would you include: Consider all training modes, training parameters, and a progression plan. Note a rational for your choices. FPTA Spring Conference 2015: Lower Extremity Strength and Cardiovascular Training in the Post-Stroke Population: Interpreting and Applying the Evidence Based on the above Case 1, answer the following questions: Will you perform and exercise tolerance test? Why or why not? If so, which protocol would you choose? Calculate the patient’s age predicted max heart rate. Calculate 40%, 65% and 85% max heart rate values. Based on this patients current functional status and medical history please provide a plan of care addressing how you will improve cardiovascular health. Consider all options regarding volume of energy expenditure, frequency, intensity and duration. Please provide a rationale. Would you expect to find any limitations in assessing the patient’s response to exercise? If so, how else can you assess patient’s aerobic effort? Based on the above case 2, answer the following questions: Will you perform and exercise tolerance test? Why or why not? If so, which protocol would you choose? Calculate the patient’s age predicted max heart rate. Calculate 40%, 65% and 85% max heart rate values Based on this patients current functional status and medical history please provide a plan of care addressing how you will improve cardiovascular health. Consider all options regarding volume of energy expenditure, frequency, intensity and duration. Include mode of training. Please provide a rationale. BORG Scale 0-10 <5 5-6 7-8 % HR max <64% 64-76% 77-93% 60-84% 3.0-5.9 >/= 6.0 Moderate Vigorous 40-59% 1.1-2.9 Created by: Melanie Lomaglio, PT, MSc, NCS Lindsay Perry, PT, DPT, NCS <40% An evidenced based reference tool for aerobic and resistance training: risk assessment, screening, and implementation guidelines for physical therapists. Low %HRR (relative) METS (Absolute) Scientific statement from the American Heart and Stroke Association (2014). “Physical Activity and exercise prescription should be incorporated into the management of stroke survivors. The promotion of physical activity in stroke survivors should emphasize low– to moderate–intensity aerobic activity, muscle strengthening, reduction of sedentary behavior, and risk management for secondary prevention of stroke.”1 A clinical guide to exercise prescription post stroke Intensity The benefits of exercise post stroke outweigh the risks1 AHA/ASA/ACSM Resistance training recommendations1,2 In medically stable patients post stroke, muscle strengthening and muscle endurance training is recommended for both in-patient rehab and outpatient rehab settings and it should be offered early.1 In sedentary patients begin with: WHY Exercise Training? Secondary prevention of stroke and other CVD Build aerobic capacity to perform ADL Improve quality of life and mobility Begin with 50% 1RM (light intensity) Progress bi-weekly up to 80% 1RM Progress to 2-3 sets with 2-3 mins rest Maintain target load via bi-weekly assessment of the 1RM Estimating the 1RM 1 rep = 1 RM 2 reps = .94 3 reps = .91 4 reps = .88 5 reps = .86 6 reps = .83 7 reps = .81 8 reps = .79 9 reps = .77 10 reps = .75 11 reps = .72 12 reps = .70 13 reps = .69 14 reps = .68 15 reps = .66 16 reps = .65 Count number of reps to failure with a selected weight (body weight can be used). From the table select the corresponding decimal percentage associated with the number of reps completed. 1 RM = weight lifted / %RM 1 RM x.50 = target load for sedentary beginner Structured aerobic exercise programs for stroke survivors are strongly recommended by level 1 evidence. 1 Build Cardiorespiratory fitness Volume: 500-1000 METS/week Reduce depression and social isolation Intensity: 40-59% HRR for moderate, 6084%HRR for vigorous 1 set of 10-15 reps of 8-10 exercises 2-3 days per week ASA/AHA Aerobic training recommendations Before beginning a physical exercise program that exceeds low intensity (40%HRR), medical clearance via stress test is recommended. In lieu of a stress test, submax tests may be considered in the following order: YMCA/TBRS submax exercise test 6 minute walk test (correlate VO2 max) Use of BORG RPE scale Contraindications3 Medical instability of diabetes, angina, arrhythmias Uncontrolled HRrest, >100 bpm or <50 bpm Resting Systolic BP >200 mmHg or < 90mmHg Resting Diastolic BP >110mmHg Oxygen Saturation < 90% Duration: 150 min/week at moderate OR 75 min/week at vigorous intensity. **Can also perform multiple 10 minute bouts** Frequency: 3-5x/week Estimating Target HR (THR) Calculate resting heart rate Calculate Max HR = 220-age Heart rate reserve = (% THRX) X (HRmax—HRrest) + HRrest References 1. Billinger, SA et al. Stroke. 2014; 45:2532-53. 2. Garber CE et al. Med Sci Sports Exercise. 2011;43:1334-59. 3. Fletcher BJ et al. Cardiac precautions for non acute inpatient setting. Am. J. Phys Med Rehabil. 1993. 72:140-143. 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