GPS Product Safety Summary
Document Number: GPSSR-136
C12-14 Alkyl-N,N-dimethyl-N-(2-hydroxyethyl)ammonium chloride.
GENERAL STATEMENT
GPS summary is intended to provide a general overview of the chemical substances in context of ICCA Global
Product Strategy. The information in the summary is general information about the chemical properties &
hazards involved to human & environment. Additional information is available through the relevant Safety Data
Sheet, which should be consulted before use of the chemical.
The substance C12-18 Alkyl-N,N-dimethyl-N-(2-hydroxyethyl)ammonium chloride is a UVCB substance
CHEMICAL IDENTITY
Name
:
C12-14 Alkyl-N,N-dimethyl-N-(2-hydroxyethyl)ammonium chloride
Common Name
:
Chemical Name (IUPAC)
:
EC Number
:
Quaternary ammonium compounds, C12-14,
even numbered, alkyl(hydroxyethyl) dimethyl, chlorides (HYEQS).
N-(2-hydroxyethyl)-N,N-dimethyl alkyl-C12-14-(even numbered)-1aminium chloride
288-474-7
CAS Number
:
85736-63-6
Molecular Formula
:
(CnH2n+1)(CH3)2(HOCH2CH2)N+Cl- with n = 12 - 14
Molecular Weight Range
:
294 to 323
Structure
:
USES AND APPLICATIONS
The substance C12-14 Alkyl-N,N-dimethyl-N-(2-hydroxyethyl)ammonium chloride is used as a surface active
agent and is raw material for detergents (mainly washing and cleaning products in form of regular and compact
powder).
PHYSICAL/CHEMICAL PROPERTIES
Property
Form
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Value
Waxy solid with characteristic odour
GPS Product Safety Summary
Physical state
Solid
Colour
colorless
Melting point
195 °C
Explosive properties
no explosive properties to be expected
Water solubility
1400 mg/L at 25 °C
Octanol-water
partition coefficient
(Log Kow)
2.3 at 25 °C
Vapour Pressure
< 0.001 Pa at 20°C
Relative density
1 g/L (= kg/m³) at 20°C
Self ignition
temperature
no self ignition temperature up to 400°C
Oxidising properties
no oxidising properties to be expected
Flammability
Not classified as flammable
HEALTH EFFECTS
Human Health Safety Assessment
Effect Assessment
Acute Toxicity
Oral / inhalation /
dermal
Irritant effect on skin
& eyes
Sensitisation
Toxicity after
repeated exposure
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Results
Harmful if swallowed
Causes severe skin burns and eye damage
skin sensitization testing was not conducted with HYEQS as the test substance
is corrosive. Testing was performed with preparations of HYEQS
demonstrating no skin sensitization potential under known conditions of use.
May cause damage to gastro-intestinal tract epithelium through prolonged or
repeated exposure by oral route
Genotoxicity /
Mutagenicity
Not mutagenic
Carcinogenicity
No carcinogenicity to be expected
Toxicity for
reproduction
No reproductive toxicity to be expected
GPS Product Safety Summary
ENVIRONMENTAL EFFECTS
Environment Safety Assessment
Effect Assessment
Aquatic toxicity
Results
Very toxic to aquatic life
Fate and Behaviour
Results
Biodegradation
Readily biodegradable
Bioaccumulation
potential
low bioaccumulation potential
PBT / vPvB conclusion
neither a PBT nor a vPvB substances
EXPOSURE
Human health (combined for all exposure routes)
Consumer: The assessment of the uses of Quaternary ammonium compounds, C12-14, even numbered
alkyl(hydroxyethyl)dimethyl, chlorides (HYEQS) within the relevant product category (Washing and Cleaning
Products) revealed for all expected exposures and for all relevant exposure routes (dermal, inhalation, oral) safe
use conditions. Based on the very low exposure levels revealed, the derived RCC values are well below any
concern levels which demonstrate that HYEQS in household consumer products do not pose any health risk.
Workers: Quaternary ammonium compounds, C12-14, even numbered, alkyl(hydroxyethyl) dimethyl,
chlorides (HYEQS) is produced batchwise in closed systems in a controlled reactor under pressure and under inert
conditions. Afterwards the product - substance as approx. 40% aqueous solution – is transferred directly via pipe
into the storage tank. Production includes material transfers and mixing (dilution) in closed systems. Related
operational activities include material transfers, dilution, mixing, drying, quality control sampling and large scale
and small scale packaging. The assessment for all relevant process categories identified for this exposure scenario
revealed that all activities related to inhalation and/or dermal exposure are controlled to exposure levels which
represent no concern.
Environment
The environmental exposure and risk during manufacturing, formulation, professional and consumer use of
Quaternary ammonium compounds, C12-14, even numbered, alkyl(hydroxyethyl) dimethyl,chlorides (HYEQS) is
determined by the wide dispersive use consumer use of detergent powder with HYEQS. The environmental risk
characterisation ratio for production, formulation, professional and consumer use is well below 1 for the tonnage
used in the EU. Based on the assessment safe uses for all environmental scenarios have been identified.
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GPS Product Safety Summary
RISK MANAGEMENT RECOMMENDATIONS
Appropriate risk management measures are in use for manufacturing and downstream use of Quaternary
ammonium compounds, C12-14, even numbered, alkyl(hydroxyethyl) dimethyl, chlorides (HYEQS). These include
the use of closed manufacturing systems, appropriate ventilation systems (as needed) and personal protective
equipment (as appropriate).
STATE AGENCY REVIEW
This substance has been registered under REACH.
REGULATORY INFORMATION / CLASSIFICATION AND LABELLING
Labelling according CLP regulation:
Hazard pictogram:
GHS05: corrosion
GHS09: environment
Hazard statements:
H314: Causes severe skin burns and eye damage.
H302: Harmful if swallowed.
H400: Very toxic to aquatic life.
Precautionary statements:
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash thoroughly after handling.
P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container
Signal Word:
Danger
CONCLUSION
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GPS Product Safety Summary
CONTACT INFORMATION WITHIN COMPANY
Clariant Produkte (Deutschland) GmbH
65926 Frankfurt am Main
Telephone no. : +49 69 305 18000
GLOSSARY
Acute toxicity: harmful effects after a single exposure
Biodegradable: breakdown of materials by a physiological environment
Bioaccumulation : accumulation of substances in the environment
Carcinogenicity: effects causing cancer
Chronic toxicity: harmful effects after repeated exposures
Clastogen: a substance that causes breaks in chromosomes
Embryotoxicity: harmful effects on foetal health
GHS: Global Harmonized System
Hazard: situation bearing a threat to health and environment
Mutagenicity: effects that change genes
Reprotoxicity: combining teratogenicity, embryotoxicity and harmful effects on fertility
Sensitising: allergenic
Teratogenic: effects on foetal morphology
DATE OF ISSUE
November 2011
REVISION
ADDITIONAL INFORMATION
DISCLAIMER
The information contained in this paper is intended as advice only and whilst the information is provided in
utmost good faith and has been based on the best information currently available, is to be relied upon at the
user’s own risk.
No representations or warranties are made with regards to its completeness or accuracy and no liability will be
accepted by Clariant for damages of any nature whatsoever resulting from the use of or reliance on the
information.
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