Santosh Kumar, Ph.D. July 2014
CURRICULUM VITAE
NAME: SANTOSH KUMAR, Ph. D.
DATE: 07/2014
h-index: 19
i-10-index: 29
CURRENT POSITION AND ADDRESS
Associate Professor
Department of Pharmaceutical Sciences
College of Pharmacy
University of Tennessee Health Science Center
881 Madison Ave.
Memphis, TN 38163
Phone: 901-448-7157 (off)
Phone: 409-370-1664 (cell)
Email: [email protected]
EDUCATION
06/1998
06/1993
01/1991
Ph. D. Biotechnology, Biotechnology Center, Indian Institute of Technology (IIT),
Bombay 400076, India
M. S. Biotechnology, Biotechnology Center, IIT, Bombay 400076, India
B. S. Chemistry, ARSD College, University of Delhi, New Delhi 110021, India
PROFESSIONAL APPOINTMENTS
UTHSC
06/2008 - Current
Associate Professor, Department of Pharmaceutical Sciences, College of
Pharmacy, University of Tennessee Health Science Cet
UMKC
09/2008 - 06/2008
Assistant Professor, Division of Pharmacology and Toxicology, School of
Pharmacy, University of Missouri-Kansas City (UMKC)
Prior to UMKC
03/2008 - 08/2008
06/2005 - 02/2008
08/2002 - 05/2005
07/1998 - 07/2001
Assistant Research Scientist, Department of Pharmacy and Pharmaceutical
Sciences University of California San Diego, San Diego, CA 92093
Research Assistant Professor, Department of Pharmacology and Toxicology,
University of Texas Medical Branch (UTMB), Galveston, TX 77555
Research Instructor, Department of Pharmacology and Toxicology, UTMB,
Galveston, TX 77555
Post-Doctoral Fellow, School of Biological Sciences, (UMKC), Kansas city, MO
64110
PROFESSIONAL DEVELOPMENT
UTHSC
1. Special Populations Research Development Seminar Series, National Institute of Drug Abuse,
Bethesda, MA, 2013-14: Phase II workshop (mock review of a 12-page R01) on June 26-27.
1
Santosh Kumar, Ph.D. July 2014
UMKC
1. Professional Development Conference, Johnson College Community College, May 15, 2009: One
day workshop by the experts in the field.
2. FACET Teaching Skills Development Symposium, UMKC, 2010: One day workshop by the
experts in the field
3. Non-native Speaking Faculty Workshop by Michael Dix, UMKC, 2011: One day workshop.
4. NIH Grant Writing Workshop by David Morrison, UMKC 2011: One day combined workshop
followed by one-one-one discussion on my R01 grant proposal.
4. Professional Development Conference, Johnson College Community College, May 23, 2012: One
day workshop by expert in the field.
5. Special Populations Research Development Seminar Series, National Institute of Drug Abuse,
Bethesda, MA, 2013-14: It was a two day workshop in to promote R01 grant proposal to new
investigators. I presented a R01 concept paper (6- pages) and had one-onone discussion with two mock reviewers. They selected my project for
phase II workshop (mock review of a 12-page R01, Jun e 26-27).
UTMB
1. Teaching improvement project system (TIPS) for health care educators, Sep 2006, UTMB: Two
days workshop by UTMB personnel. I received the best teaching
assessment as a “Coach”.
2. NIH workshop for grant writing, Oct 2007, UTMB: One Day workshop by NIH personnel.
MEMBERSHIP IN SCIENTIFIC SOCIETIES
UMKC
04/2012 – 03/2013
08/2010 - current
11/2009 - current
04/2003 - current
International Society for Neurovirology (ISNV)
American Association of College of Pharmacy (AACP)
Society on NeuroImmune Pharmacology (SNIP)
American Society for Pharmacology and Experimental Therapeutics (ASPET)
UTMB
03/2003 - 2008
American Society for Biochemistry and Molecular Biology (ASBMB)
HONORS AND AWARDS
UTHSC
08/2014
Faculty Row, The Official Home Of America's Top Faculty™
UMKC
Honors and Awards
05/2014
12/2013
11/2013
11/2013
“Teacher of the Year award” Runner up from the class of 2015, School of
Pharmacy, UMKC
Mahatma Gandhi Pravasi (Non-resident Indian (NRI)) Samman (Honor). This is
presented to 30 NRIs every year to recognize their contribution in the field.
Nomination for Burroughs Wellcome Fund for “Investigators in the
Pathogenesis of Infectious Diseases”
Nomination for Chancellor’s Early Career Award for Excellence in Teaching
2
Santosh Kumar, Ph.D. July 2014
07/2013
03/2013
01/2013
11/2012
09/2012
08/2012
07/2012
07/2012
06/2012
06/2012
05/2012
04/2012
03/2012
12/2011
08/2011
06/2009
10/2008
Selected to participate in the National Institute on Drug Abuse (NIDA) Special
Populations Research Development Seminar Series on September 19-20, 2013
in Bethesda, Maryland
Invited as contributing member of ‘FACULTY OF 1000 (F1000)': Invitation
accepted
Invited to write a book chapter in Industrial Biocatalysis, Pan Stanford
Publishing Pte. Ltd., Singapore: Invitation accepted
Invited to write a review in Expert Opinion on Drug Metabolism and Toxicology
(IF = 3.1): Invitation accepted, manuscript in review
Invited to write a review in Mini Reviews in Organic Chemistry (IF = 2.4):
Invitation accepted, manuscript in review
Invited renowned speaker of a symposium, “HIV-1, Substance abuse, and
NeuoAIDS”, 3rd World Congress in Biotechnology, Sep 13-15
Editor of special issue entitled: "Cytochrome P450: Drug interactions” for
Journal of Drug Metabolism and Toxicology, OMICS publications
NIDA/AAPI Travel Fellowship Award, Tobacco/smoking, HIV/AIDS, and Cancer
Workshop, 7th Annual Texas Conference on Health Disparities, 2012
Editor of special issue entitled: "Enzymatic degradation of environmental
pollutants using transgenic plants” for Journal of Petroleum and Environmental
Biotechnology, OMICS publications
Elected Chair: Early Stage Investigator Committee-Society of NeuroImmune
Pharmacology (ESIC-SNIP)
NIDA Young Investigator travel award for HIV in the Nervous System and the
11th International Symposium on Neurovirology, 2012
Nomination for UMKC Outstanding Faculty Award for iPhD student mentoring
Invited to write a review in Expert Opinion on Drug Metabolism and Toxicology
(IF = 3.1)
Invited Guest speaker and Co-chair of a symposium, 44th Annual Indian
pharmacological Society Conference (IPSCON), Dec 19-21
Invited for Young Investigator Committee-SNIP member
Invited to write a review in Expert Opinion on Drug Metabolism and Toxicology
(IF = 3.5)
Biography in Who's Who in the World
UTMB
2008
2007
2007
2006
2003
1998
1995
Biography in Who's Who in America
Special invitation to facilitate a problem-based learning (PBL) on Gastrointestinal nutrition
Biography in Who's Who in Science and Engineering
Highest score as a Teacher/Facilitator in the category of Instructional set,
Teacher tactics, and Verbal and nonverbal behaviors in a Teaching Workshop
ASPET Drug Metabolism Division Post-doctoral Best Paper Award
Nomination for the Best Thesis Award (The President Gold Medal Award)
Vice-President of SYMBIOTEK (Society for the young member of
Biotechnology), Biotechnology Center, IIT, Bombay - 400076
COMMITTEE
A. National and International
UTHSC (2014 - Current)
Ad-hoc reviewer for many scientific journals
3
Santosh Kumar, Ph.D. July 2014
2014
PLoS ONE
UMKC (2009 - 2014)
03/2013 - current
Member: Toxicology section of Pharmacology and Drug Discovery, FACULTY
OF 1000 (F1000)
Recommended eight research articles
07/2012 - current
Editor: Special issue entitled: "Cytochrome P450: Drug interactions” for Journal
of Drug Metabolism and Toxicology, OMICS publications
06/2012 - current
Editor: Special issue entitled: "Enzymatic degradation of environmental
pollutants using transgenic plants” for Journal of Petroleum and Environmental
Biotechnology, OMICS publications
06/2012 – 04/2015
Elected Chair: Early Career Investigator Committee-Society of NeuroImmune
Pharmacology (ECIC-SNIP)
Role:
1. Selection for Travel award to attend SNIP meeting: Total applicants: ~75
2. Organization of poster sessions and selection for best poster awards in SNIP
meeting: Total posters: ~90
3. Organize and Co-chair of Early Career Investigator Symposium: Total
speakers: 6
4. Organize Meet-the-Mentor Lunch: Total attendees: ~140
03/2012- current
Executive Editor: Petroleum and Environmental Biotechnology
09/2011 - current
Member: Early Career Investigator Committee-Society of NeuroImmune
Pharmacology (ECIC-SNIP)
11/2010 - current
Associate Editor: The Journal of Drug Metabolism and Toxicology (Open
access Bioinfo publications)
07/2010 - current
Ad-hoc Editor: Journal of Drug Metabolism and Toxicology, Petroleum and
Environmental Biotechnology. (Open access OMICS publication)
01/2011 - current
Advisory Editorial Board for International Journal of life Science and Pharma
Reviews
03/2011 - current
Member: Editorial Board of Pakistan Journal of Scientific and Industrial
Research, Series B: Biological Sciences
01/2008 - current
Ad-hoc reviewer for many scientific journals
2008
1. Drug Metab. Dispos.
(Total 1)
2009
Drug Metab. Dispos.
Chem. Res. Toxicol.
Protein Eng. Des. Selec.
Mol. Biol. Evol.
Free Rad. Biol. Med.
(Total 5)
2010
Exp. Opin. Drug Metab. Toxicol.
Int. J. Neurosci
PloS One
Alcoholism: Clin. Exp. Res.
4
Santosh Kumar, Ph.D. July 2014
J. Antiv. Antiretrov.
Bulletin for Environmental Toxicology
J. Amino Acids
Bulletin for Environmental Contamination and Toxicology
Trends in Biotechnology
(Total 9)
2011
Alcoholism: Clin Exp. Res.
J. Antiv. Antiretrov.
Free Rad. Biol. Med.
Pakistan Journal of Scientific & Industrial Research
J. Antiv. Antiretrov.
Xenobiotica
J. NeuroImmune Pharmacology
(Total 7)
2012
Current HIV research
Drug metabolism letters
J. Antiv. Antiretrov.
Bull. Environ. Contamin. Toxicol. (2)
Int. J. Mol. Sci.
Drug Alcohol Dependence
Mol. Cell. Biochem.
Free Rad. Biol. Med.
J. AIDS Clin. Res.
Int. J. Mol. Sci.
Mol. Cell Biochem.
Drug Metab. Dispos.
Cancer Lett.
(Total 14)
2013
PLOS ONE (4)
AIDS Clin. Res. (2)
Free Rad. Biol. Med.
Enz. Microb. Technol.
Frontiers Biosci.
Brit. J. Clin. Pharmacol.
J. Proteomic Res
J. AIDS Clin. Res.
Drug Metab. Dispos.
Virology Journal
Clinical Pharmacology: Advances and Applications
Toxicology and Applied Pharmacology
PLoS ONE (2)
Molecular Cancer
Drug Metabolism and Disposition (2)
2014
UTMB
08/2005 - 2008
Drug Metab. Dispos.
Chem. Res. Toxicol.
Arch. Biochem. Biophys.
Enz. Microb. Technol.
Protein Eng. Des. Selec.
Chem. Biol. Interact.
5
Santosh Kumar, Ph.D. July 2014
(Total 6)
GRANT REVIEWER
UTHSC (2014 – Current)
1. Institutional Pilot Project Program, Ponce University, School of Medicine
2.
UMKC (2009 - current)
1. American Association of College of Pharmacy (AACP): one grant
2. University of Missouri Research Board (UMRB): two grants
3. National Institute of Health: NeuroAIDS and other end organ diseases
(NAED): 4 grants
UTMB (2007-2008)
4. Austrian Science Fund (FWF): one grant
5. University of Houston Research Council GEAR Grant: one grant
B. UMKC COMMITEES
09/2008 - 08/2009
1. Member, Graduate Program Committee, School of Pharmacy
3. Member, Assessment Sub-committee, School of Pharmacy
2. Member, Research Strategic Committee, Pharmacology and Toxicology
09/2009 - 08/2010
1. Member, Graduate Program Committee, School of Pharmacy
2. Member, School of Pharmacy representative to the Undergraduate
Curriculum Committee, UMKC
3. Member, Research Strategic Committee, Pharmacology and Toxicology
09/2010 - 08/2011
1. Member, Graduate Program Committee, School of Pharmacy
2. Member, School of Pharmacy representative to the Undergraduate
Curriculum Committee
3. Member, Hazardous Material Oversight, School of Pharmacy
09/2011 - 08/2012
1. Member, Graduate Program Committee, School of Pharmacy
2. Member, Information Technology, School of Pharmacy
3. Member, School of Pharmacy representative to UMKC senator committee
(Elected)
09/2012 - 08/2013
1. Member, Graduate Program Committee, School of Pharmacy
2. Member, Research Advisory Council, School of Pharmacy (Elected)
3. Faculty Development Committee
4. Member, School of Pharmacy representative to UMKC senator committee
(Elected)
09/2013 - 08/2014
1. Member, Graduate Program Committee, School of Pharmacy
2. Member, Research Advisory Council, School of Pharmacy (Elected)
3. Member, Information Technology
4. Member, School of Pharmacy representative to UMKC senator committee
(Elected)
5. Member, Professionalism
6. Alternate Chair, Honor council (Elected)
6
Santosh Kumar, Ph.D. July 2014
09/2013 - Current
Faculty advisor of two Pharmacy students of class of 2017: 1. Yuna Eun, 2.
Cecilia Vu
09/2012 - Current
Faculty advisor of four Pharmacy students of class of 2016: 1. Kelsi Ezell, 2.
Jonathan Gregory, 3. Tim Miller, and 4. Tuan Vu
08/2012 - 09/2012
Faculty search committee: Clinical Assistant Professor in the Division of
Pharmacy Practice and Administration
11/2012 - Current
Faculty search committee: Assistant/Associate Professor in the Division of
Pharmacology and Toxicology
09/2009 - Current
1. Doctoral faculty, School of Pharmacy
2. Graduate faculty, School of Pharmacy
09/2010 - Current
Supervisory Committee Member for iPhD Students (Coordinating discipline)
Name
Plan of study Comprehensive
Thesis
Placement
1. Nanda Mandava
May 2010
May 2011
Sep 2013
2. Sandeep Putty
March 2011
Nov 2011
May 2014
Senior scientist
Pharmacopoeia
Scientist
Bristol-Myer
3.
4.
5.
6.
May 2011
May 2011
July 2011
Sep 2011
Dec 2012
April 2012
Jan 2012
Feb 2014
March 2014
Jan 2013
7. Mitan Gokulgandhi
Sep 2011
May 2012
Aug 2013
8. Mitesh Patel
9. Ankit Shah
Nov 2011
Nov 2011
Dec 2012
April 2012
Nov 2013
PDF, SOP, UMKC
10. Sudheer Bobba
Jan 2012
March 2012
May 2013
Scientist, Covance
Laboratories
11. Ravi Shukla
Feb 2012
May 2013
May 2014
PDF,John Hopkins
12. Animikh Ray
13. Xun Lu
14. Jake McQuire
15. Amruta Ronghe
16. Anwesha Chatterjee
17. VKC Ponnaluri
18. Divya T Vavilala
19. Mohit Gangwani
20. Lu Cao
21. Anantha Nookala
22. Harika Vemula
23. Wei Jin
Aug 2012
Aug 2012
Feb 2012
Oct 2012
Oct 2012
Nov 2012
Nov 2012
April 2013
May 2013
Sep 2013
Nov 2013
Dec 2013
Nov 2013
March 2014
Oct 2012
Jan 2014
Dec 2013
Jan 2013
Aug 2013
June 2014
Julia C. Reis
Ashaben Patel
Ramya Badlapatla
Megha Barot
Five students have graduated.
7
Scientist
Pharmacopoeia
Scientist
Pharmacopoeia
June 2014
May 2014
May 2014
PDF
PDF
Santosh Kumar, Ph.D. July 2014
09/2009 - Current
Chair, Supervisor/Mentor of iPhD Students from Pharm/Tox
Name
Plan of study Comprehensive
Thesis
Placement
1. Mengyao Jin
May 2011
Dec 2012
PDF, UNCChapel Hill
2. Anusha Ande
Oct 2012
March 2012
One student has graduated.
C. UTMB
2005 - 2006
1. Supervisory Committee Chair/Mentor for a MS student (Cynthia Hernandez),
Graduate School of Biomedical Sciences (GSBS)
2. Medical Student Interview Panel, School of Medicine (SOM)
3. Summer Medical Student Poster’s Judging Panel, SOM
2003 - 2007
2003 - 2007
COMMUNITY SERVIVE
A. Local
06/2011
Seminar/Workshop for High School students titled “Common Drug Metabolism,
Clearance, and Toxicity”, School of Pharmacy, UMKC
TEACHING: CLASSROOM
A. UMKC
1. School of Pharmacy
01/2008 - current
PHARMACY 7361/5519 (Pharmacology I, Fall and Summer): Team taught
course. Summer course includes self-study examinations.
PHARMACY 7362/5520 (Pharmacology II, Spring and Summer): Team taught
course. Summer course includes self-study examinations.
Assistant coordinator: Spring 2012 and 2013
Coordinator: Spring 2014
PHARMACY 7463/5509 (Toxicology, Spring): Team taught course
Drug interactions/Adverse reactions, Adrenergic agonists/antagonists,
Introduction to chemotherapy, Cell wall synthesis inhibitors, Sulfonamides,
Quinolones, Antivirals, Anti-tuberculosis, Antineoplastics, Drugs for Asthma,
Thyroid and anti-thyroid drugs, Insulin and Oral hypoglycemics, Dietary
Supplements and Herbal Medicine
Credits: ~3/year
01/2008 - Current
PHARMA 5616: Methods in Pharmacology and Toxicology
Credits: ~3 (2-3 students/year)
09/2011 - Current
01/2013 - Current
Developed, coordinates, and teaches (sole Instructor) a new Elective
Graduate and Pharmacy Course: Fall Semester
Pharmacy 5630
Cytochrome P450: Drug Metabolism, Bioavailability, Interactions, and Toxicity
(CYP: DMBIT)
Credits: 3
Pharmacy 7497D Directed individual study for Pharm D students
8
Santosh Kumar, Ph.D. July 2014
1. Bradley Stockard, P3 Pharm D. Spring 2012, Credits: 2
2. Morgan Kohls, P2 Pharm D. Spring 2013, Credits; 2 (scheduled)
Performance evaluation overall score
Mandatory Pharmacy and Graduate course: ~155 students
Spring 2009
Pharmacology II
4.14/5
Fall 2009
Pharmacology I
4.18/5
Spring 2010
Pharmacology II
4.14/5
Fall 2010
Pharmacology I
4.20/5
Spring 2011
Pharmacology II
4.22/5
Fall 2011
Pharmacology I
4.07/5
Spring 2012
Pharmacology II
4.28/5
Fall 2012
Pharmacology I
4.37/5
Spring 2013
Pharmacology II
4.53/5
Fall 2013
Pharmacology I
4.71/5
Elective Graduate and Pharmacy course: 6-10 students
Fall 2011
CYP: DBMIT
4.60/5
Fall 2012
CYP: DBMIT
4.77/5
B. UCSD
1. Skaggs School of Pharmacy and Pharmaceutical Sciences
03/2008-06/2008
Taught Drug metabolism in Pharmaceutical Biochemistry: Drug Target
Mechanism.
B. UTMB
1. School of Medicine
2007 - 2008
Taught Cell wall synthesis inhibitors, Sulfonamides, Quinolones in Graduate
Pharmacology Survey Course: Special Topics - PHTX 6000.
2005 - 2007
Facilitated problem-based learning (PBL) courses Gastro-intestinal Nutrition
and Cardiovascular and Pulmonary for the 2nd year Medical students.
Performance evaluation overall score
2005:
Cardiovascular and Pulmonary:
2006:
Gastro-intestinal nutrition:
2007:
Gastro-intestinal nutrition:
01/2007
4.0/5
4.7/5
3.7/5
Taught lectures on “Antibiotics and its Pharmacology” for Graduate
Pharmacology Survey Course: PHTX 6000 (ECT-Endo/ Chemo/Tox Pharm).
C. IITB
1995 - 1997
1995 - 1996
Taught Biochemistry and Enzymology to MS students, Biotechnology Center
Taught Biochemistry and Biotechnology to BS students, Dept. of Biotechnology,
V. G. Vaze College of Arts, Commerce & Science, Mulund (E), Bombay
MENTORING/TRAINING: RESEARCH AND SCHOLARSHIP
A. UMKC
Post-doctorate fellows
9
Santosh Kumar, Ph.D. July 2014
1. Ravinder Earla
June 2010 - June 2014
2. P.S. Shantanu Rao
March 2014 - current
Graduate students (iPhD.)
1. Mengyao Jin (2009-2012):
Dean Student Award 2011
Travel Award “Society of NeuroImmune Pharmacology” 2011
Travel Award “Society of NeuroImmune Pharmacology” 2012
Women Council Award 2012
2. Anusha Ande (2011-current): Women Council Award 2012
Best Student of the Year Award 2012
Women Council Award 2013
Dean Student Award 2013
Travel Award “Society of NeuroImmune Pharmacology (SNIP)”
2013
Preparing Future Faculty Scholar Award 2013-14
Travel Award and Plateform Speaker, SNIP 2014
3. Ken McFarlin (2011-current): Richard and Paula Johnson Pharmacy Graduate Student
Scholarship 2012
Graduate students in Laboratory Methods course
1. Gautham Kodakandla
2. Stephani Stancil
3. Zhang Yan
4. Kshitij Verma
5. James Weemhoff
6. Ananth Nookala
7. Lu Cao
8. Mohit Gangawani
9. Anusha Ande
10. Priyanka Arya
11. Xun Liu
12. Shruti Kamath
13. Amruta Ronghe
14. Gautham Rao
Research Assistant
1. Namita Sinha
Summer undergraduate students
1. Ken Marvin McFarlin
High school students
1. Parnita Harsh
Year
2013
2012
2012
2012
2011
2011
2011
2011
2010
2009
2009
2009
2009
2008
Grade
A
A
A
A
A
A
A
B
A
A
B
A
B
B
Year
10/11 - 05/12
Year
06/11 - 07/11
Year
07/13 (three weeks)
B. UTMB
Graduate students (MS)
1. Cynthia Hernandez (2005-2007): Best poster award at 5th SWP450 meeting; second place.
Graduate Laboratory Rotation students Year
Grade
10
Santosh Kumar, Ph.D. July 2014
1. Fan Yi
2. Robert Malmstrom
3. Tori Strong
2005
2004
2004
B
A
A
Year
Award
1. Alva Gullstrand
2. Yan Larson
2006
2005
3. Jeeba Kuriakose
2004
None
Best poster, 1st Place
Joined UTMB for PhD in 2006
Best poster, 1st Place
Joined UTMB for PhD in 2005
Summer Undergraduate students
Post-doctorate fellows (trained)
Year
1. Wataru Honma
2. Harshica Farnando
3. Jyothi Talakad
2005
2006
2007
Research Associate (trained)
Year
1. Ling Sun
2005
Trained lab personnel
1. Hazard Communication Act
2. Laboratory Safety
3. Radioactive Safety Program
C. UMKC
Graduate laboratory rotation student
1. Kanwarjit Singh Chadha (SBS)
Year
Grade
2000
A
RESEARCH INTERESTS
A. Alcoholism is highly prevalent in HIV-1-infected individuals. Alcohol consumption is known to
enhance HIV-1 replication. In addition, alcohol is known to decrease the response to
antiretroviral drugs. However, the mechanism by which these occur is not known. We propose
that alcohol-mediated increase in HIV-1 replication occurs through cytochrome P450 (CYP),
especially CYP2E1-mediated oxidative stress. Similarly, we propose that alcohol-mediated
decrease in response to antiretrovirals occurs through CYP3A4 pathway. Our ongoing project
is “Role of cytochrome P450 in alcohol-mediated HIV-1 pathogenesis and antiretroviral
therapy”. This project is funded by NIH/NIAAA R01 grant until Aug 2018 (percentile 2).
B. Smoking is highly prevalent in HIV-1-infected individuals. Smoking is known to enhance HIV-1
replication. However, the mechanism by which it occurs is not known. We propose that
tobacco-mediated increase in HIV-1 replication occurs through cytochrome P450 (CYP),
especially CYP2A6-mediated oxidative stress. Our ongoing project is Tobacco/nicotine, CYPs,
and HIV-1. This project is funded by NIH/NIDA R21 grant until April 2014.
C. CYP enzymes are of considerable interest for the: i) synthesis of novel drugs and drug
metabolites, ii) targeted cancer gene therapy, iii) biosensor design, and iv) bioremediation.
However, their applications are limited because cytochrome P450, especially mammalian
P450 enzymes, show a low turnover rate and stability, and require a complex source of
electrons through cytochrome P450 reductase and NADPH. Our ongoing projects are
Engineering CYP enzymes to study structure-function relationships.
11
Santosh Kumar, Ph.D. July 2014
GRANT SUPPORT
UTHSC: ONGOING
1. Start-up fund:
(PI: Kumar, S.)
06/01/2014 - 05/31/2017
$500,000/ 3 years
School of Pharmacy, UMKC
Title: Cytochrome P450 engineering, drug interactions, alcohol abuse, and HIV-1
2. R01
(PI: Kumar, S. 25% effort) 06/01/2014 - 05/31/2014
$960,000/ 4 years
National Institute of Alcohol Addiction and Alcoholism (NIAAA)
Title: Role of cytochrome P450 in alcohol-mediated HIV-1 pathogenesis and antiretroviral therapy
UMKC: COMPLETED
1. Start-up fund:
(PI: Kumar, S.)
09/01/2008 - 08/31/2012
$250,000/ 4 years
School of Pharmacy, UMKC
Title: Cytochrome P450 engineering, drug interactions, alcohol abuse, and HIV-1
2. New Investigator Grant: (PI: Kumar, S.)
08/01/2010 - 07/31/2012
University of Missouri Research Board (UMRB)
Title: Effect of Alcohol & HIV Drugs on Cytochrome P450
$28,000/ 2 year
3. Bridge funding: (PI: Kumar, S.)
10/01/2012 - 09/30/2013
$14,860/ 1 year
School of Pharmacy
Title: Role of cytochrome P450 in alcohol-mediated HIV-1 pathogenesis and antiretroviral therapy.
The funding is to generate additional preliminary data to revise the following scored (29) NIAAA/NIH
R01 proposal.
3. R21
(PI: Kumar, S. 20% effort)
05/01/2011 - 04/30/2014
National Institute of Drug Abuse (NIDA)
Title: Tobacco/nicotine, Cytochrome P450, and HIV-1
$275,000/ 3 years
4. R01
(Co-investigator: Kumar, S. 10% effort) 09/01/12 - 08/31/17
National Institute of Alcohol Addiction and Alcoholism (NIAAA)
Title: Alcohol abuse and HIV-mediated neurotoxicity (PI: Kumar, A.)
$1,000,000/ 5 years
5. R01
(PI: Kumar, S. 25% effort) 09/01/2013 - 05/31/2014
$1,125,000/ 5 years
National Institute of Alcohol Addiction and Alcoholism (NIAAA)
Title: Role of cytochrome P450 in alcohol-mediated HIV-1 pathogenesis and antiretroviral therapy
6 Bridge funding: (PI: Kumar, S.)
11/01/2013 - 10/31/2014
School of Pharmacy
Title: Role of cytochrome P450 in tobacco-mediated HIV-1 pathogenesis.
The funding is to generate preliminary data to submit a R01 grant to NIDA.
$14,881/ 1 year
SUBMITTED (Scored and Discussed, but not funded)
1. R03
(PI: Kumar, S.)
04/16/2009
National Institute of alcohol abuse and alcoholism (NIAAA)
Title: Interactions between alcohol and anti-retroviral drugs
Priority Score: 280
$200,000/ 2 years
2. R21
(PI: Kumar, S.)
12/19/2010
$275,000/ 2 years
National Cancer Institute (NCI)
Title: Engineering CYP2C18 for enhanced cytotoxicity of the anti-cancer prodrug cyclophosphamide
Priority Score: 58
3. R01
(PI: Kumar, S.)
10/10/2011
$1,250,000/ 5 years
National Institute of Genral Medical Sciences (NIGMS)
Title: Examination of the role of E-H helix region in CYP structure-function using alternate approaches
Priority Score: 34; Percentile: 31
12
Santosh Kumar, Ph.D. July 2014
4. Investigator in Pathogenesis
(PI: Kumar, S. 20% effort) 11/01/2013
Burroughs Wellcome Fund
Title: Cytochrome P450 pathways in tobacco-mediated HIV-1 pathogenesis
$500,000/ 5 years
UTMB: COMPLETED
1. 05/01/03 – 04/30/04 (Completed): Pilot Grant, ES06676, (PI: Kumar, S.)
$10,000/ 1 year
National Institute of Environmental Health Sciences (NIEHS) Center Grant, UTMB, Galveston, TX
77555
Title: Development of a directed evolution approach for mammalian cytochrome P450s
RESEARCH COLLABORATIONS: ONGOING AT UMKC-UTHSC
1. Dr. Anil Kumar, Professor and Chairman, Pharmacology and Toxicology, School of Pharmacy,
University of Missouri-Kansas City
Tel: (816) 235-1792, Email: [email protected]
Title: Substance abuse, anti-retroviral therapy, and NeouroAIDS
Thirteen publications (S. Kumar: Eight as lead author and five as supporting author)
2. Dr. Ashim K. Mitra, Professor and Chairman, Pharmaceutical Sciences, School of Pharmacy,
University of Missouri-Kansas City
Tel: (816) 235-1615, Email: [email protected]
Title: Tobacco, anti-retroviral drugs, and Cytochrome P450
Three publications (S. Kumar: All three as lead author)
3. Dr. Carole McArthur, Professor, Department of Oral Biology, School of Dentistry, University of
Missouri-Kansas City
Tel: (816) 235-2175, Email: [email protected]
Title: Tobacco/Nicotine, Cytochrome P450, and HIV-1
One publication (S. Kumar: As supporting author)
RESEARCH COLLABORATIONS: COMPLETED AT UMKC-UTMB
1. Dr. Leszek Wojnowski, Professor, Institut für Pharmakologie, Johannes Gutenberg-Universität,
Obere Zahlbacher Str. Mainz, Germany
Tel: (+49) 6131 39 33460, Web-Fax: (+49) 941 5992 36727, E-mail: [email protected]
Title: Structural basis of the functional diversity of ancestral and chimpanzee CYP3A4 compared with
the human CYP3A4
One publication
2. Dr. Dmitri Davydov, Associate Professor, Skaggs School of Pharmacy and Pharmaceutical
Sciences, University of California, san Diego
Tel: (858) 822-7804; Email: [email protected]
Title: Cooperativity of bacterial P450eryF
Two publications
3. Dr. Mary Moslen-Treinen, Professor, Director Toxicology Program, Department of Pathology and
Department of Pharmacology and Toxicology, University of Texas Medical Branch
Tel: (409) 772-3650; Email: [email protected]
Title: Efficient high performance liquid chromatography/ultraviolet method for determination of
diclofenac and 4’hydroxydiclofenac in rat serum
One publication
13
Santosh Kumar, Ph.D. July 2014
4. Dr. B. K. Muralidhara, Senior Scientist, Pfizer Inc., PhRD-Global Biologics, St. Louis
Tel: (713) 582-4869; Email: [email protected]; [email protected]
Title: P450 stability and structure-function using CD, fluorescence, and isothermal titration calorimetry
Three publications
5. Dr. Hong Liu, Professor, Shanghai Institute of Materia Medica, Chinese Academy of Sciences,
Drug Discovery and Design Center, Shanghai, P.R. China; Email: [email protected]
Title: Molecular modeling of P450 using protein dynamics and substrate docking
Three publications
6. Dr. Werner Braun, Professor, Department of Biochemistry and Molecular Biology and The Sealy
Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch
Tel: (409) 747-6810; Email: [email protected]
Title: Identification and structural and functional analyses of conserved sequence motifs in
mammalian cytochrome P450
One publication
7. Dr. Dan Rock, Senior Scientist, Pharmacokinetics & Drug Metabolism, Amgen, Seattle
Tel: (206) 265-7139; Email: [email protected]
Title: Differential time dependent inhibition of P450 3A4 and P450 3A5 by raloxifene: A key role for
C239 in quenching reactive intermediates
One publication
8. Dr. David J. Waxman, Professor, Department of Biology, Boston University,
Tel: (617) 353-7403, Email: [email protected]
Title: Engineering of cytochromes P450 2B and 2C for enhanced metabolism of the anti-cancer
prodrugs CPA and IFA
Three publications
INVITED LECTURES
UMKC
1. Role of cytochrome P450 pathways in alcohol- and tobacco-mediated HIV-1 pathogenesis,
School of Pharmacy, Texas Tech Health Science Center, Amarillo, TX, January 12, 2014
2. Role of cytochrome P450 pathways in alcohol- and tobacco-mediated HIV-1 pathogenesis,
College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN,
December 16, 2013
3. Role of cytochrome P450 in alcohol-mediated oxidative stress and HIV-1 pathogenesis, The
Department of Immunology, Institute of Neuroimmune pharmacology, and Center for
Personalized Nanomedicine, Herbert Wertheim College of Medicine, Florida International
University, July 18, 2013
4. Role of cytochrome P450 enzymes in tobacco/nicotine-mediated effects on HIV-1 model
systems, Symposium: Physiological and Pathological role of nicotinic receptors, Society of
Neuroimmune Pharmacology, San Juan, PR, April 3-6, 2013
5. Role of cytochrome P450 enzymes in alcohol-mediated effects on antiretroviral and HIV-1,
Division of Pharmaceutical Sciences, School of Pharmacy, UMKC February 12, 2013.
6. Role of cytochrome P450 enzymes in alcolhol-mediated effects on antiretroviral and HIV-1,
The Department of Pharmacology, Toxicology &Therapeutics, University of Kansas Medical
Center, Nov 20, 2012.
14
Santosh Kumar, Ph.D. July 2014
7. Central role of cytochrome P450 2A6 in tobacco-mediated oxidative stress in maccrophages
and astrocytes: implications with HIV-1 pathogenesis and neuroAIDS, Symposium: HIV-1,
Substance abuse, and NeuoAIDS, 3rd World Congress in Biotechnology, Hyderabad, India,
Sep 13-15, 2012.
8. Central role of cytochromes P450 in alcohol and tobacco-mediated oxidative stress in
maccrophages and astrocytes: implications with HIV-1 pathogenesis and neuroAIDS,
Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India, Sep 18,
2012.
9. Central role of cytochrome P450 2A6 in tobacco-mediated oxidative stress in maccrophages
and astrocytes: implications with HIV-1 pathogenesis and neuroAIDS, Tobacco/smoking,
HIV/AIDS, and Cancer Workshop, 7th Annual Texas Conference on Health Disparities, 2012.
10. Central role of cytochromes P450 2A6 in tobacco-mediated oxidative stress in maccrophages
and astrocytes: implications with HIV-1 pathogenesis and neuroAIDS, HIV in the Nervous
System and the 11th International Symposium on Neurovirology, 2012.
11. Tobacco/alcohol, Cytochrome P450, and HIV-1, Division of Oral Biology, School of Dentistry,
UMKC March 07, 2012.
12. Reengineering of Cytochrome P450 for Medicine and Biotechnology, National Institute of
Pharmaceutical Education and Research (NIPER), Dec 23rd, 2011.
13. Tobacco/alcohol, Cytochrome P450, and HIV-1, 44th Annual Conference of Indian
Pharmacological Society, Manipal, India; December 19-21, 2011.
14. Role of cytochrome P450 in alcohol/nicotine-mediated oxidative stress and alcoholantiretrovirals interaction, Division of Pharmacology and Toxicology, School of Pharmacy,
UMKC February 03, 2011.
15. Effect of alcohol and antiretroviral therapeutics on cytochrome P450s in macrophages:
Relevance to alcoholic HIV-1 patients. Division of Pharmaceutical Sciences, School of
Pharmacy, UMKC February 09, 2010.
16. Cytochrome P450-mediated drug interactions and adverse effects, International Conference
on Integrative & Personalized Medicine and 42nd Annual Conference of Indian
Pharmacological Society, Kolkata, India; December 12, 2009.
17. Conserved sequence motifs as an approach to study structure-function relationships of
mammalian cytochromes P450, 8th SWP450 meeting, Camp Allen, Navasota, TX; May 2009.
UTMB
18. Engineering xenobiotic-metabolizing mammalian cytochromes P450 to study structure-function
and generating biocatalysts, NIEHS Center Seminar Series at UTMB, Galveston, TX; 2008.
(Invited)
19. Designing mammalian cytochromes P450 for enhanced activity and stability. 6th SWP450
meeting, Camp Allen, Navasota, TX, 2007. (Invited)
20. Engineering of xenobiotic-metabolizing mammalian cytochromes P450 using directed
evolution. Biotransformation Seminar Series, UTMB, Galveston, TX; 2006. (Invited)
21. Use of directed evolution of mammalian cytochromes P450 for investigating the molecular
basis of enzyme function and generating novel biocatalysts. 5rd SWP450 meeting, Camp
Allen, Navasota, TX, 2006.
22. Use of directed evolution of mammalian cytochromes P450 for investigating the molecular
basis of enzyme function and generating novel biocatalysts. NIEHS Center Seminar Series at
UTMB, Galveston, TX; 2005. (Invited)
15
Santosh Kumar, Ph.D. July 2014
23. Engineering cytochrome P450 2B1: rational vs. irrational approach. Department of
Pharmacology and Toxicology, University of Texas Medical Branch, Galveston TX; 2004.
24. Directed evolution approach to engineer mammalian cytochromes P450 for enhanced/altered
biological functions. IUBMB/ASBMS 2004, Boston, MA; 2004. (Invited)
25. Allosteric modulation of CYP3A4 by -naphthoflavone and cytochrome b5: evidence by H2O2supported 7-benzyloxyquinoline oxidation, substrate binding, heme-depletion assays. 3rd
SWP450 meeting, Camp Allen, Navasota, TX; 2004. (Invited)
26. Analysis of H2O2-supported 7-benzyloxyquinoline debenzylation by CYP3A4: effect of the naphthoflavone and cytochrome b5. Biotransformation Seminar Series, UTMB, Galveston, TX;
2004. (Invited)
27. Mammalian cytochromes P450: rational vs. irrational design, NIEHS Center Seminar Series at
UTMB, Galveston, TX; 2003. (Invited)
28. Engineering of cytochrome P450 2B1 for progesterone 21-hydroxylase activity. Drug
Metabolism Division Platform Session, EB2004, San Diego, CA; 2003. (Invited)
29. Systematic approach to convert cytochrome P450 regioselectivity across
Biotransformation group seminar series, UTMB, Galveston, TX; 2002. (Invited)
subfamilies,
30. Engineering of cytochrome P450 2B1 for progesterone 21-hydroxylase activity. 2nd SWP450
meeting, Camp Allen, Navasota, TX; 2002.
31. Cytoplasmic dynein molecular motor: its clutch, gear, accelerator, brake, and cargo. SIUC 6 th
Annual Molecular and Cellular Biology, Symposium, Southern Illinois University, Carbondale,
IL; 2000. (Invited)
BIBLIOGRAPHY
A. THESIS UNDER MY SUPERVISION (UMKC)
Role of cytochrome P450 enzymes on alcohol/nicotine-mediated oxidative stress and cytotoxicity
in monocytes/astrocytes: Implications for HIV-infected alcohol/tobacco users
Jin, Mengyao (University of Missouri--Kansas City, 2013-03-13) http://hdl.handle.net/10355/33199
B.
ARTICLES/REVIEWS IN PEER-REVIEWED JOURNALS
Citations: 869 (548 since 2009)
h-index: 19 (14 since 2009)
i10-index: 29 (26 since 2009)
UMKC
1. Earla, R., Ande, A., McArthur, C., Kumar, A., Kumar, S. Enhanced nicotine metabolism in HIV1-infected smokers than uninfected smokers: Simultaneous determination of nicotine and its
four metabolites in plasma using a simple and sensitive ESI-LC-MS/MS, Drug Metab. Dispos.
42, 282-293, 2014 (IF - 3.7, Citation - 0).
2. Silverstein, P., Kumar, A., Kumar, S. Alcohol, antiretroviral therapy, HIV-1, HCV, and
neurotoxicity. Curr. HIV Res. Accepted (IF - 2.0, Citation - 0)
16
Santosh Kumar, Ph.D. July 2014
3. Shah, A., Kumar, S., Simon, S.D., Singh, D.P., and Kumar, A. HIVgp120 and
methamphetamine-mediated oxidative stress increases astrocyte apoptosis via cytochrome
P450 2E1. Cell Death and Disease, 4, e850, 2013 (IF - 5.3, Citation - 0)
4. Ande, A., McArthur, C., Kumar A., Kumar, S., Tobacco smoking effect on HIV-1
pathogenesis: Role of cytochrome P450 isozymes. Exp. Opin. Drug Metab. Toxicol. 9,14531464, 2013 (IF - 3.1, Citation – 0)
5. Ande, A., McFarlin, K., Kumar, S., Smoking, alcohol consumption, and oxidative stress. MiniRev. Org. Chem. Accepted (IF - 2.4, Citation - 0)
6. Kumar, S., Phytoremediation of explosives using transgenic plants, Petroleum and
Environment Biotechnology. S4, 001, 2013.(IF - 3.4, Citation - 0)
7. Jin, M., Ande, A., Kumar, A., Kumar, S., Regulation of Cytochrome P450 2E1 Expression by
Ethanol: Role of Oxidative Stress-mediated PKC/JNK Pathway. Cell Death Disease (Nature
publication), 4, e554 2013 (Corresponding author, S. Kumar) (IF - 5.3, Citation - 1)
8. Shah A., Silverstein, P.A. Kumar, S., Singh, D.P., Kumar, A. Synergistic cooperation between
methamphetamine and HIV-1GP120 through the PI3K/AKT pathway induces IL-6 but not IL-8
expression in astrocytes. PLoS ONE, 7, e52060, 2012 (IF - 4.4, Citation - 2)
9. Kumar, S., Challenges and Opportunities of Cytochrome P450-Mediated Phytoremediation.
Petrol. Envir., Biotechnol. 4, 1-2, 2012. (IF - 3.1, Citation - 1), Editorial article
10. Kumar, S. Jin, M., Ande, A., Sinha, N., Silverstein, P., Kumar, A., Alcohol consumption effect
on antiretroviral therapy and HIV-1 pathogenesis: Role of cytochrome P450 isozymes. Exp.
Opin. Drug Metab. Toxicol. 8, 1363-1375, 2012. (IF - 3.1, Citation - 2)
11. Kumar, S., Jin, M., Weemhoff, J., Cytochrome P450-mediated phytoremediation using
transgenic plants: A need for engineered cytochrome P450 enzymes. Petrol. Envir.,
Biotechnol. 3, 1-5, 2012. ( (IF - 3.1, Citation - 5)
12. Jin, M., Kumar, A., Kumar, S., Ethanol mediated induction of cytochrome P450 2A6: Role of
oxidative stress-mediated PKC/MEK-Nrf2 pathway. PLoS ONE, 7, e35505, 2012. (IF - 4.4,
Citation - 5)
13. Kumar, S. Role of cytochrome P450 in substance abuse mediated HIV-1 pathogenesis and
neuroAIDS. J. Drug Metab. Toxicol., 3, 1-4, 2012. (IF - 1.3, Citation - 1), Editorial article
14. 1Ande, A., 1Earla, R., Jin, M., Silverstein, P.S., Mitra, A.K., Kumar, A., Kumar, S., An LCMS/MS Method for Concurrent Determination of Nicotine Metabolites and the Role of CYP2A6
in Nicotine Metabolite-mediated Oxidative Stress in SVGA Astrocytes. Alcohol and drug
dependence, 125, 49-59, 2012. (IF - 4.0, Citation - 4). Highlighted in Global Medical
Discovery News, Dec 18, 2012 and Psychology progress, Feb 19, 2013.
15. Silverstein, P.S., Shah, A., Weemhoff, J., Kumar, S., Singh, D.P., Kumar, A., HIV-1 gp120 and
Drugs of Abuse: Interactions in the Central Nervous System. Current HIV Research, 10, 369383, 2012. (IF - 2.0, Citation - 0)
16. Bristow, C.L., Babayeva, M.A., Modarresi, R., McArthur, C.P., Kumar, S., Awasom, C., Ayuk,
L., Njinda, A., Achu, P., Winston, R. The α-test: Rapid Cell-free CD4 Enumeration Using
Whole Saliva. The Journal of Visualized Experiments, e3999, 2012. (On line Journal, IF - NA,
Citation - NA) video: http://www.jove.com/details.php?id=3999&status=a6005k
17. 1Jin, M., 1Earla, R. Shah, A., Rajya L. Earla, Gupte, R., Mitra, A. K., Kumar, A., and Kumar,
S., A LC-MS/MS method for concurrent determination of CYP2A6-mediated nicotine
metabolites and analysis of nicotine-mediated oxidative stress in U937 macrophages. J.
NeuroImmune Pharmacol. 7, 289-299, 2012. (IF - 3.5, Citation - 6)
18. Oezguen, N., Kumar, S., Analysis of cytochrome P450 conserved sequence motifs between
helices E and H: Prediction of critical residues for enzyme functions. J. Drug Metab. Toxicol. 2,
110-114, 2011. (IF - 1.3, Citation - 1)
19. Silverstein, P., Shah, A., Gupte, R., Liu, X., Piepho, R., Kumar, S., and Kumar A.
Methamphetamine Toxicity and its Implications During HIV-1 Infection. J. Neurorovirology. 17,
401-415, 2011. (IF - 1.2, Citation - 9)
17
Santosh Kumar, Ph.D. July 2014
20. Kumar S. and Kumar, A., Effect of ethanol on spectral binding and inhibition of CYP3A4 with
protease inhibitors: An analysis of CYP3A4-potease inhibitors interactions. Alcohol: Clin. Exp.
Res. 35, 2121-2127, 2011 (IF - 3.4, Citation - 2)
21. Jin, M., Arya, P. Patel, K., Singh, B., Silverstein, P., Bhat, H., Kumar, A., and Kumar, S.,
Effect of alcohol on drug efflux protein and drug metabolic enzymes in U937 macrophages.
Alcohol Clin. Exp. Res., 35, 1-8, 2011. (IF - 3.4, Citation - 12)
22. Kumar, S., Earla, R., Jin, M., Mitra, A. K., and Kumar, A., Effect of ethanol on spectral
binding, inhibition, and activity of CYP3A4 with an antiretroviral drug nelfinavir. Biochem.
Biophys. Res. Commun., 402, 163-167, 2010. (IF - 2.7, Citation - 7)
23. Rivera-Amil, V. Kumar, R., Noel Jr., R. J., Garcia, Y., Rodriguez, I. V., Martinez, M., Sariol, C.,
Kraiselburd, E., Iszard, M., Mukherji, M., Kumar, S., Giavedoni, L. D., and Kumar, A., Lack of
Immune Response in Rapid Progressor Morphine-Dependent and SIV/SHIV-infected Rhesus
Macaques is Correlated with Down-regulation of TH1 Cytokine. AIDS Research and Human
Retroviruses, 26, 919-922, 2010. (IF - 2.1, Citation - 3)
24. Rivera-Amill, V., Silverstein, P. S., Noel, R.J., Kumar, S., and Kumar, A., Morphine and rapid
disease progression in non-human primate model of AIDS: Inverse correlation between
disease progression and virus evolution. J. NeuroImmune. Pharmacol. 5, 122-132, 2010. (IF 3.7, Citation - 5)
25. Talakad, J. C., Wilderman, R. P., Davydov, D. R., Kumar, S., and Halpert, J. R., Engineering
cytochromes P450 2B6 and 2B11: An insight into the role of residue 334 for stability. Arch.
Biophys. Biochem. 494, 152-158, 2010. (IF - 2.9, Citation - 11)
26. Kumar, S., Engineering cytochrome P450 biocatalysts for biotechnology, medicine, and
bioremediation. Exp. Opin. Metabol. Toxicol. 6: 1-17, 2010. (IF - 3.5, Citation - 33)
27. Kumar, S., Qiu, H., Oezguen, N., Herlyn, H., Halpert, J. R., and Wojnowski, L., Ligand
diversity of human and chimpanzee CYP3A4: Activation of human CYP3A4 by lithocholic acid
results from positive selection. Drug Metab. Dispos. 37, 1328-1333, 2009. (IF - 3.7, Citation 2)
28. Sun, H., Moore, C., Dansette, P. M., Kumar, S., Halpert, J. R., and Yost, G. S.
Dehydrogenation of the indoline-containing drug, indapamide, by CYP3A4: Correlation with in
silico predictions. Drug Metab. Dispos. 37: 672-684, 2009. (IF - 3.7, Citation - 15)
Note: Among the above publications, eighteen are from my projects, seven are from Dr. A.
Kumar’s projects, two are from Dr. Halpert’s project, one is from Dr. Wojnowski’s project, and
one is from Dr. McArthur’s project.
Current total citation is approximately 950.
Prior to UMKC
29. Talakad, J. C., Kumar S., Halpert, J. R., Decreased susceptibility of the cytochrome P450
2B6 variant K262R to inhibition by several clinically important drugs. Drug Metab. Dispos. 37,
644-650, 2009. (IF - 3.7, Citation - 18)
30. 1Oezguen, N., 1Kumar, S., Hindupur, A., Braun, W. Muralidhara, B. K., and Halpert, J. R.
Identification and analysis of conserved motifs in cytochrome P450 family 2: Functional role of
a motif 187RFDYKD192 in P450 2B enzymes. J. Biol. Chem. 283, 21808-21816, 2008. (IF - 5.3,
Citation - 10)
31. Pearson, J. T., Wahlstrom, J. L., Dickmann, L. J. Kumar, S., Halpert, J. R. Wienkers, L. C.,
Foti, R. S., and Rock, D. A. Differential time-dependent inhibition of P450 3A4 and P450 3A5
by raloxifene: A key role for C239 in quenching reactive intermediates. Chem. Res. Toxicol.
20, 1778-786, 2007. (IF - 4.1, Citation - 30)
32. Kumar, S. Zhao, Y., Sun, L., Halpert, J. R, and Muralidhara, B. K., Engineering human
cytochrome P450 2B6 for
enhanced expression and stability: Importance of Leu264Phe
substitution. Mol. Pharmacol. 46, 11559-11567, 2007. (IF - 4.1, Citation - 17)
18
Santosh Kumar, Ph.D. July 2014
33. Zhao, Y., Sun, L., Muralidhara, B. K., Kumar, S., White, M., Stout, D. C., Halpert, J. R.
Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to
cytochrome P450 2B4. Biochemistry, 281, 5973-5981, 2007. (IF - 3.2, Citation - 36)
34. Kumar, S. Identification of a novel laser dye substrate of mammalian cytochromes P450:
Application in rapid kinetic analysis, inhibitor screening, and directed evolution. J. Biomol.
Screen. 12, 677-682, 2007. (IF - 2.5, Citation - 3)
35. Sun, L., Chen, C. S., Waxman, D. J., Hong Liu, and Halpert, J. R., and Kumar, S. Reengineering cytochrome P450 2B11dH for enhanced metabolism of several substrates
including the anti-cancer prodrugs cyclophosphamide and ifosfamide. Arch. Biochem.
Biophys., 458, 167-174, 2007. (IF - 2.9, Citation - 19)
36. Kumar, S. and Halpert, J. R. Use of directed evolution of mammalian cytochromes P450 for
investigating the molecular basis of enzyme function and generating novel biocatalysts.
Biochem. Biophys. Res. Commun. 336, 456-464, 2005. (IF - 2.7, Citation - 30)
37. Kumar, S., Sun, L., Muralidhara, B. K., and Halpert, J. R. Engineering mammalian
cytochrome P450 2B1 by directed evolution for enhanced catalytic tolerance to temperature
and dimethyl sulfoxide. Protein Eng. Des. Selection, 19, 547-554, 2006. This article’s figure
was accepted for the cover page caption. (IF - 3.0, Citation - 36)
38. Kumar, S. Liu, H., and Halpert, J. R. Engineering of cytochrome P450 3A4 for enhanced
peroxide-mediated substrate oxidation using directed evolution and site-directed mutagenesis.
Drug Metab. Dispos. 34, 1958-1965, 2006. (IF - 3.7, Citation - 31)
39. Hernandez, C. E., Kumar, S. Liu, H., and Halpert, J. R. Investigating the role of active site
residues of the ligand-bound cytochrome P450 2B4dH/H226Y on ligand binding and substrate
metabolism. Arch. Biochem. Biophys. 455, 61-67, 2006. (IF - 2.9, Citation - 15)
40. Kaphalia, L., Kaphalia, B., Kumar, S., Kanz, M. F., and Moslen, M. T. Efficient high
performance liquid chromatography/ultraviolet method for determination of diclofenac and
4’hydroxydiclofenac in rat serum. Journal of Chromatography B, 830, 231-237, 2006. (IF - 4.1,
Citation - 22)
41. Kumar, S., Davydov, D. R., and Halpert, J. R. Role of cytochrome b5 in modulating peroxidesupported CYP3A4 activity: evidence for a conformational transition and P450 heterogeneity.
Drug Metab. Dispos. 33, 1131-1136, 2005. (IF - 3.7, Citation - 29)
42. Kumar, S., Chen, C. S., Waxman, D. J., and Halpert, J. R. Directed evolution of mammalian
cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several
substrates including the anticancer prodrugs cyclophosphamide and ifosfamide. J. Biol.
Chem. 280, 19569-19575, 2005. (IF - 5.9, Citation - 61) Reprinted in a special issue
“Cytochrome P450 Today”, J. Biol. Chem., 2009.
43. Davydov, D. R, Botchkareva. A. E., Kumar, S., He, Y. Q., and Halpert, J. R. An electrostatic
driven conformational transition is involved in the mechanism of substrate binding in
cytochrome P450eryf. Biochemistry 43, 6475-6485, 2004. (IF - 3.2, Citation - 31)
44. Kumar, S., Scott, E. E., Liu, H., and Halpert, J. R. A rational approach to re-engineer
cytochrome P450 2B1 regioselectivity based on the crystal structure of P450 2C5. J. Biol.
Chem. 178, 17178-17184, 2003. (IF - 5.9, Citation - 54)
45. Davydov, D. R., Kumar, S., and Halpert, J. R. Allosteric mechanisms in P450eryF with 1pyrenebutanol: a novel fluorescent probe. Biochem. Biophys. Res. Commun. 294, 806-812,
2002. (IF - 2.7, Citation - 28)
46. Kumar, S., Zhou Y., and Plamann, M. Dynactin-membrane interaction is regulated by the CGlued
. EMBO Reports 2, 939-944, 2001. (IF - 10, Citation - 21)
terminal domains of p150
47. Lee, I. H., Kumar, S., and Plamann, M. Null mutants of the Neurospora crassa Arp1 pointedend complex show distinct phenotypes. Mol. Biol. Cell. 12, 2195-2206, 2001. (IF - 6.1, Citation
- 33)
48. Kumar, S., Lee, I. H., and Plamann, M. Cytoplasmic dynein ATPase is regulated by dynactindependent phosphorylation. J. Biol. Chem. 275, 31798-31804, 2000. (IF - 6.7, Citation - 38)
19
Santosh Kumar, Ph.D. July 2014
49. Kumar, S., Lee, I. H., and Plamann, M. Two approaches to isolate dynein ATPase from
Neurospora crassa. Biochimie 82, 229-236, 2000. (IF - 3.8, Citation - 3)
50. Kumar, S., Punekar, N. S., Satyanarayan, V., and Venkatesh, K. V. Metabolic fate of
glutamate and evaluation of flux through the 4-Aminobutyrate (GABA) shunt in Aspergillus
niger. Biotechnol. Bioeng. 67, 575-584, 2000. (IF - 3.7, Citation - 32)
51. Kumar, S., Punekar, N. S. Inhibitor of succinic semialdehyde dehydrogenease by Nformylglycine. J. Enz. Inhib. 13, 369-176, 1998. (IF - 1.6, Citation - 1)
52. Kumar, S. Muscular dystrophy: A genetic disorder. BRIDGE June report, 1998. (IF - NA,
Citation - NA)
53. Kumar, S. Enzymes Vs Extremozymes. RESONANCE: J. Sci. Edu. 3, 32-40, 1998. (IF - NA,
Citation - 3)
54. Kumar, S., Punekar, N. S. The metabolism of 4-aminobutyrate (GABA) in fungi. Mycol. Res.
101, 403-409, 1997. (IF- 2.9, Citation - 28)
55. Punekar, N. S., Meera G., Sudarshana, S., and Kumar, S. Mechanism of acidogenesis in
Aspergillus niger: Status of nitrogen metabolism. In "Microbes for better living", Proc. MICON94, 9-12, 1994. (IF - NA, Citation - NA)

Corresponding author
contributions

Unofficial 2011 Impact Factors were established by dividing the number of articles published in 2010
and 2011 were cited in 2011 based on a search of the Google Scholar Citation Index database, by the
number of articles published in the previous two years (2010 and 2011).
IF: Impact factor
1Equal
C. BOOK CHAPTERS
1. Santosh Kumar, Cytochrome P450 Biocatalysts - Current Applications and Future Prospects
(2013) In “Industrial Biocatalysis”, Pan Stanford Publishing, Singapore (USA: Boca Raton, FL)
B. ABSTRACTS
UMKC
1. Earla, R., Ande, A., Mitra, A.K., Kumar, A., Kumar, S. Role of CYP2A6 in nicotine metabolism
studied using newly developed LC-MS/MS-SPE method in hiv-1 models monocytes and
astrocytes, and plasma from HIV-infected smokers. 19th SNIP Conference, San Juan, PR, April
3-6, 2013.
2. Ande, A., Sinha, N. McArthur, C., Kumar, S. Role of cytochrome P450 (CYP) in smoking and
alcohol mediated oxidative stress: implications with HIV-1 pathogenesis. 19th SNIP
Conference, San Juan, PR, April 3-6, 2013.
3. Jin, M., Ande, A., Kumar, A., Kumar, S. Regulation of cytochrome P450 2E1 expression by
ethanol: role of oxidative stress-mediated PKC/JNK/SP1 pathway. 19th SNIP Conference, San
Juan, PR, April 3-6, 2013.
4. Kumar, S., Role of cytochrome P450 enzymes in tobacco/nicotine-mediated effects on HIV-1
model systems. 19th SNIP Conference, San Juan, PR, April 3-6, 2013.
5. Earla, R., Ande, A., Jin, M., Silverstein P.S., Mitra, A.K., Kumar, A., and Kumar, S., Nicotine
Metabolism-mediated Oxidative Stress in Astrocytes and Macrophage Studied by using 3200
QTRAP Tandem Mass Spectrometry, American Association of Pharmaceutical Scientists,
Chicago, IL, Oct 14-18, 2012.
6. Kumar, S. Central role of cytochromes P450 in tobacco-mediated oxidative stress in
maccrophages and astrocytes: implications with HIV-1 pathogenesis and neuroAIDS, 3rd
World Congress in Biotechnology, Hyderabad, India, Sep 13-15, 2012.
20
Santosh Kumar, Ph.D. July 2014
7. Ande, A., Sinha, N., McArthur, C., Kumar, S. Central role of cytochromes P450 2A6 in
tobacco-mediated oxidative stress in macrophages and astrocytes: implications with hiv-1
pathogenesis and neuroAIDS, 9th ISNV Conference, New York, NY, May 29-June 02, 2012.
8. Kumar, S., Ande, A., Sinha, N., McArthur, C. Central role of cytochromes P450 2A6 in
tobacco-mediated oxidative stress in macrophages and astrocytes: implications with hiv-1
pathogenesis and neuroAIDS, 7th Smoking, HIV/AIDS, and Cancer in Health Disparity, Fort
Worth, TX, July 11-13, 2012.
9. Ande A., Jin, M., McArthur, C., Kumar A., and Kumar, S., Role of CYP2A6 in nicotine
metabolism mediated oxidative stress in monocytes and astrocytes: Implications in HIV-1,18th
SNIP Conference, Honolulu, HI, April 25-28, 2012.
10. Jin, M., Kumar A., and Kumar, S., CYP2E1-mediated alcohol metabolism induces expressions
of CYP2A6 and CYP2E1 through oxidative stress-induced PKC signaling cascades in
monocytes and astrocytes, 18th SNIP Conference, Honolulu, HI, April 25-28, 2012.
11. Kumar, S. and Jin, M., Central role of Cytochromes P450 (CYP) in alcohol-mediated oxidative
stress and alcohol-antiretroviral therapy (ART) interactions, 18th SNIP Conference, Honolulu,
HI, April 25-28, 2012.
12. Kumar, S. and Kumar, A., Tobacco/alcohol, Cytochrome P450, and HIV-1. 44th Annual
Conference of Indian Pharmacological Society, Manipal, India, Dec 20-22, 2011.
13. Earla, R., Jin, M., Shah, A., Rajya L. Earla, Gupte, R., Mitra, A. K., Kumar, A., and Kumar, S.,
A LC-MS/MS method for concurrent determination of CYP2A6-mediated nicotine metabolites
and analysis of nicotine-mediated oxidative stress in U937 macrophages, American Society of
Mass Spectrometry, Denver, CO, June 5-9, 2011
14. Kumar, S. and Kumar, A., Effect of ethanol on CYP3A4-protease inhibitors physical
interactions as determined by spectral binding and enzyme inhibition, 17th SNIP Conference,
Clearwater Beach, FL, April 6-10, 2011.
15. Gupte, R., Shah, A., Kumar, S., Kumar, A., Acute ethanol exposure induced upregulation of
IL-6and IL-8 in astrocytes is mediated by NFκB pathway, 17th SNIP Conference, Clearwater
Beach, FL, April 6-10, 2011.
16. Jin, M., Earla, R., Shah, A., Gupte, R., Mitra, A.K., Kumar, A., Kumar, S., The role of
cytochrome P450 on alcohol/nicotine-mediated oxidative stress in U937 macrophages, ;
1School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO 64108-0000. 17th
SNIP Conference, Clearwater Beach, FL, April 6-10, 2011.
17. Kumar, S., Jin, M., Silverstein, P., Kumar, A., Effect of alcohol on cytochrome P450 in
monocytes/macrophages: Implications in anti-retroviral therapy and oxidative stress, 16th SNIP
Conference, Manhattan Beach, CA, April 130-17, 2010.
18. Jin, M., Silverstein, P., Kumar, A., Kumar, S., Cytochrome P450-mediated drug interactions
and adverse effects, International Conference on Integrative & Personalized Medicine and
42nd Annual Conference of Indian Pharmacological Society, Kolkata, India, Dec 12-15, 2009.
19. Wojnowski, L., Kumar, S., Qiu, H., Oezguen, N., Herlyn, H., Halpert, J. R., Ligand diversity of
human and chimpanzee CYP3A4: Activation of human CYP3A4 by lithocholic acid results from
positive selection, Annual Meeting of the German Society of Pharmacology, Mainz, Germany,
2009.
20. Kumar, S., Oezguen, N., Braun, W., and Halpert, J.R. Conserved sequence motifs as an
approach to study structure-function relationships of mammalian cytochromes P450, 8th
SWP450 meeting, Camp Allen, Navasota, TX; 2009.
Prior to UMKC
21. Talakad, J. C., Sun, L., Kumar, S. and Halpert, J.R. Characterization of the P450 2B6 genetic
variant K262R for temperature stability and drug binding, EB/ASPET, San Diego, CA, 2008.
22. Kumar, S., Talakad, J.C., Sun, L., and Halpert, J.R. Engineering of cytochrome P450 2B6 for
enhanced expression, stability, and functional studies of the wild-type and genetic variants,
EB/ASPET, San Diego, CA, 2008.
21
Santosh Kumar, Ph.D. July 2014
23. Kumar, S., Sun L., Chen, C. S., Waxman, D. J. and Halpert, J. R. Designing mammalian
cytochromes P450 for enhanced activity and stability. 6th SW P450 meeting, Camp Allen,
Navasota, TX, 2007.
24. Kumar, S., Sun L., Chen, C. S., Waxman, D. J. and Halpert, J. R. Designing mammalian
cytochromes P450 for enhanced activity and stability. 15th International Conference on
Cytochrome P450, Bled, Slovenia, 2007.
25. Kumar, S., Liu, H., and Halpert, J. R. Use of directed evolution of mammalian cytochromes
P450 for investigating the molecular basis of enzyme function and generating novel
biocatalysts. 5rd SW P450 meeting, Camp Allen, Navasota, TX, 2006.
26. Kumar, S., Liu, H., and Halpert, J. R. Directed evolution of mammalian cytochromes P450 for
investigating the molecular basis of enzyme function and generating novel biocatalysts.
ASPET, Experimental Biology, San Francisco, CA, 2006.
27. Kumar, S., Sun, L., Muralidhara, B. K., Liu, H., and Halpert, J. R. Characterization of a
laboratory evolved cytochrome P450 2B1 mutant and its further improvement for enhanced
tolerance to organic solvents and temperature and enhanced affinity for H2O2. ASBMB,
Experimental Biology, San Francisco, CA, 2006.
28. Kumar, S., Chen, C. S., Waxman, D. J., and Halpert, J. R. Directed evolution of cytochrome
P450 2B1: mutations outside of the active site enhance the metabolism of several substrates
including the anticancer prodrug cyclophosphamide. 14th International conference on
cytochrome P450, Dallas, TX, 2005.
29. Kumar, S., Kuriakose, J., He, Y. Q. Malmstrom, R., and Halpert, J. R. A directed evolution
approach to engineer mammalian cytochromes P450 for enhanced/altered biological
functions. IUBMB/ASBMS, Boston, MA 2004.
30. Kumar, S., He, Y. A., and Halpert, J. R. Analysis of h2o2-supported 7-benzyloxyquinoline
debenzylation by CYP3A4: effect of the -naphthoflavone and cytochrome b5. 3rd SW P450
meeting, Camp Allen, Navasota, TX, 2004.
31. Kumar, S., He, Y. A., and Halpert, J. R. Analysis of H2O2-supported 7-benzyloxyquinoline
debenzylation by CYP3A4: effect of the -naphthoflavone and cytochrome b5. ASPET,
Experimental Biology, Washington D.C. 2004.
32. Kumar, S., Kuriakose, J., He, Y. Q. Malmstrom, R., and Halpert, J. R. A directed evolution
approach to engineer mammalian cytochromes P450 for enhanced/altered biological
functions. ASPET, Experimental Biology, Washington D.C. 2004.
33. Kumar S., and Halpert, J. R. A directed evolution approach to engineer cytochromes P450. 3rd
SW P450 meeting, Camp Allen, Navasota, TX, 2003.
34. Kumar, S., Scott, E. E., Liu, H., and Halpert, J. R. Engineering of cytochrome P450 2B1 for
progesterone 21-hydroxylase activity. ASPET, Experimental Biology, San Diego, CA. 2003.
35. Kumar, S., Scott, E. E., Liu, H., and Halpert, J. R. Engineering of cytochrome P450 2B1 for
progesterone 21-hydroxylase activity. Enzyme Mechanisms Conference, Galveston Island,
TX. 6; 2003.
36. Kumar, S., Scott, E. E., and Halpert, J. R. Engineering of cytochrome P450 2B1 for
progesterone 21-hydroxylase activity. 2nd Southwest P450 meeting, Camp Allen, Movasota,
TX; 2002.
37. Kumar, S., Lee, I. H., and Plamann, M. Regulation of dynein ATPase and dynactin-membrane
interaction. Experimental Biology, Orlando, FL, B13: 683.5; 2001.
38. Kumar, S., Lee, I. H., and Plamann, M. Regulation of dynactin-membrane interaction by
dynactin pointed-end complex. Gordon research Conference, Andover, NH; 2001.
39. Kumar, S., Zou, Y. and Plamann, M. Dynactin-membrane interaction is regulated by the CGlued
. 40th American Society for Cell Biology, San Francisco, CA;
terminal domains of p150
2000.
40. Kumar, S. Cytoplasmic dynein molecular motor: its clutch, gear, accelerator, brake, and
cargo. SIUC 6th Annual Molecular and Cellular Biology, Symposium, Southern Illinois
University, Carbondale, IL; 2000.
22
Santosh Kumar, Ph.D. July 2014
41. Kumar, S., Lee, I. H., and Plamann, M. Biochemical characterization of cytoplasmic dynein
from Neurospora crassa. 39th American Society for Cell Biology, Washington, D.C. 249A:
1440; 1999.
42. Kumar, S., Lee, I. H., Minke, P., Tinsley, J. and Plamann, M., Analysis of multiple alleles of
Neurospora crassa ro mutants. 20th Fungal Genetics Conference, Pacific Grove, CA. 332;
1998.
43. Kumar, S., and Punekar N. S. 4-Aminobutyrate (GABA) metabolism in normal and acidogenic
Aspergillus niger. 66th Annual Meeting of The Society of Biological Chemists, Andhra
University, Visakhapatnam, India. 1997.
44. Kumar, S., and Punekar N. S. Biochemical characterization of 4-aminobutyrate transaminases
in Aspergilli. National Symposium on Current Trends in Biochemistry and Biotechnology of
Fungi, Osmania University, Hyderabad, India. 1996.
45. Kumar, S., and Punekar N. S. Succinic semialdehyde dehydrogenase from Aspergillus niger:
A kinetic enquiry. 16th IUBMB, New Delhi, India. 1994.
D. PERSPECTIVE
1. Kumar, S., Newsletter, Society of NeuroImmune Pharmacology (SNIP), April 2012. On the
following published article in 2011 by an Early Career Investigator.
Subhas Das, Jennifer Kelschenbach, Richard Charboneau, Roderick A. Barke, and Sabita
Roy, Morphine Withdrawal Stress Modulates Lipopolysaccharide induced Interleukin 12 p40
(IL-12p40) Expression by Activating Extracellular Signal-regulated Kinase 1/2, Which Is
Further Potentiated by Glucocorticoids. J. Biol. Chem. 286, 29806–29817.
E. CONFERENCES SCENES (HIGHLIGHTS)
1. Kumar, S. Central role of cytochromes P450 2A6 in tobacco-mediated oxidative stress in
macrophages and astrocytes: implications with HIV-1 pathogenesis and neuroAIDS. Oral
presentation during Symposium on Drugs of Abuse – HIV Infection and NeuroAIDS: A Global
Perspective, during 3rd World Congress on Biotechnology, Hyderabad, India during 13-15
Sep, 2012 (Ref: "Latest trends in drugs of abuse – HIV infection and neuroAIDS". Future
Virology. 2013. 8(2): 121–127; DOI 10.2217/fvl.12.134).
F. NEWS
1. Ande, A., Earla, R., Jin, M., Silverstein, P.S., Mitra, A.K., Kumar, A., Kumar, S., An LC-MS/MS
Method for Concurrent Determination of Nicotine Metabolites and the Role of CYP2A6 in
Nicotine Metabolite-mediated Oxidative Stress in SVGA Astrocytes, Alcohol and drug
dependence,
Global
Medical
Discovery
News,
Dec
18,
2012
(http://globalmedicaldiscovery.com/?s=ande%2C+earla).
2. Ande, A., Earla, R., Jin, M., Silverstein, P.S., Mitra, A.K., Kumar, A., Kumar, S., An LC-MS/MS
Method for Concurrent Determination of Nicotine Metabolites and the Role of CYP2A6 in
Nicotine Metabolite-mediated Oxidative Stress in SVGA Astrocytes, Alcohol and drug
dependence, Psychology Progress, Feb 19, 2013. (http://psychologyprogress.com/an-lcmsms-method-for-concurrent-determination-of-nicotine-metabolites-and-the-role-of-cyp2a6-innicotine-metabolite-mediated-oxidative-stress-in-svga-astrocytes/)
G. FACULTY 1000 RECOMMENDATIONS
A total of eight articles have been recommended.
(http://f1000.com/prime/my/evaluations/approved)
23
For
detail
please
see
Santosh Kumar, Ph.D. July 2014
H. MANUSCRIPT IN REVIEW
1. Nookala, A.R. Ande, A., Li, J., Wang, L. Li, W. Kumar, S. Kumar, A. Effect of
methamphetamine on spectral binding and ligand docking of anti-HIV drugs with CYP3A4.
Drug Metab. Dispos. (IF - 3.7), In revision
2. Earla, R., Kumar, S., Wang, L., Bosinger, S., Li, J., Shah, A., Ganagwani, M.K., Nookala,
A.R., Liu, X., Cao, L., Jackson, A., Fox, H., Li, W., Kumar, A. Enhanced methamphetamine
metabolism in rhesus macaque as to human by cytochrome P450 pathways: An analysis using
a novel LCMS/MS method and docking study. Drug Metab. Dispos. (IF - 3.7), In revision
3. Ande, A., McArthur, C., Ayuk, L., Awasom, C., Achu, P.N., Njinda, A., Nookala, A., Simon, S.,
Kumar, A., Kumar, S. Effect of mild-to-moderate drinking and smoking on viral load, cytokines,
and oxidative stress in HIV-1-infected individuals. Curr. HIV Res. (IF - 2.0)
4. Ande, A., McArthur, C., Sinha N., Kumar, A., Kumar, S. Effect of drinking and smoking on
oxidative stress and expression of cytochrome P450 and antioxidant enzymes in HIV-1infected individuals in monocytes. J Neuroimmune Pharmacol. (IF - 3.8)
5.
*
Kumar, S., *Rao, P.S.S., Kumar, A. Impact of substance of abuse on antiretroviral therapy in
HIV-infected populations: Adherence, antiretroviral response, and toxicity. Exp Rev. Clin
Pharmacol. (IF -) *Equal contribution.
6. Rao, P.S.S., Cory, J.T., Kumar, S. New antiretroviral therapies and potential drug interactions
in HIV-infected drug abusers. J Antivir Antiretrovir. (IF* - 3.0)
7.
I. MANUSCRIPT UNDER PREPARATION
24