Guideline Women and Babies: Neonatal Early Assessment Program (NEAP) Document No: RPAH_GL2016_xxx Functional Sub-Group: Clinical Governance Corporate Governance Summary: The Neonatal Early Assessment Program (NEAP) consists of a risk factor assessment and four sets of measurements within the first 6 hours after birth: 1. The first physical examination. 2. The first lower limb oxygen saturation. 3. Anthropometry 4. Body fat (percentage) by air displacement plethysmography National Standard: National Standard 1 Policy Author: Original policy – Prof Heather Jeffery Updated policy – Dr Tracey Lutz (Neonatologist) Approved by: RPA Women and Babies Service Improvement Committee Publication (Issue) Date: July 2016 Next Review Date: July 2019 Replaces Existing Policy: N/A Previous Review Dates: N/A Note: Sydney Local Health District (LHD) and South Western Sydney LHD were established on 1 July 2011, with the dissolution of the former Sydney South West Area Health Service (SSWAHS) in January 2011. The former SSWAHS was established on 1 January 2005 with the amalgamation of the former Central Sydney Area Health Service (CSAHS) and the former South Western Sydney Area Health Service (SWSAHS). In the interim period between 1 January 2011 and the release of specific LHN policies (dated after 1 January 2011) and SLHD (dated after July 2011), the former SSWAHS, CSAHS and SWSAHS policies are applicable to the LHDs as follows: Where there is a relevant SSWAHS policy, that policy will apply Where there is no relevant SSWAHS policy, relevant CSAHS policies will apply to Sydney LHD; and relevant SWSAHS policies will apply to South Western Sydney LHD. Compliance with this Guideline is recommended Page 1 of 16 Neonatal Early Assessment Program (NEAP) Contents 1. Introduction 3 2. Policy Statement 3 3. Guidelines 3.1 Early Risk Factor assessment and clinical examination 3 3.2 Oxygen saturation screening 4 3.3 Anthropometry 4 3.4 Body composition - Fat measurement (fat mass, fat free mass and body fat %) 4. Figures Figure 1: Figure 2: Figure 3: Figure 4: Figure 5: Figure 6: Figure 7: Overview on how to perform NEAP Early physical examination of the newborn baby Physical examination referral pathway PeaPod quick reference guide Anthropometric referral pathway Oxygen saturation referral pathway Body Fat percentage referral pathway 7 8 9 10 11 12 12 5. Key points 13 6. References 14 Compliance with this Guideline is recommended Page 2 of 16 Sydney Local Health District Royal Prince Alfred Hospital Guideline No: RPAH_GL2013_019 September 2016 Neonatal Early Assessment Program (NEAP) 1. Introduction The risks addressed by this policy: Clinical risk of neurological damage or death of babies as a result of physical abnormalities, cardiac defects, or neonatal hypoglycaemia going undetected and untreated. The aims / expected outcome of this policy Babies with physical abnormalities, cardiac defects, or increased risk of hypoglycaemia will be identified and appropriately managed. 2. Policy Statement The goal of this guideline is to familiarise medical staff with the evidence, indications and practical management of a neonate undergoing the NEAP (neonatal early assessment program). 3. Guidelines 3.1 Early Risk Factor Assessment and Physical Examination The overall goal of the early assessment is to identify risk factors for early neonatal problems that will require regular postnatal observations, as well as identifying congenital and acquired abnormalities which may have an immediate impact on the baby’s care and/or wellbeing. Early Risk Factor Assessment All babies should be reviewed for risk factors for the five main problem areas as identified on the ‘Women and Babies Newborn Care Plan and Observations Chart (NCPOC – MR504) and ‘The Standard Newborn Observation Chart (SNOC – SMR 110.014)’. These include Risk of hypoglycaemia Respiratory distress Risk of subgaleal haemorrhage - trauma from instrumental delivery Risk of sepsis Risk of jaundice Assessment of risk of hypoglycaemia will include the anthropometric measurements and percentage body fat as outlined below. Babies identified with risk factors will need observations as outlined in the relevant RPAH guideline and on the NCPOC. Early physical examination The goal of this examination is to identify obvious external anomalies, as well as other congenital and acquired problems that may have an immediate impact on the baby’s care or well-being. This would include (but not be confined to) problems such as respiratory distress, consequences of birth trauma (e.g bruising, sub-galeal haemorrhage, nerve palsy), cleft palate, imperforate anus, abnormal genitalia and other dysmorphology. The examination should Compliance with this Guideline is recommended Page 3 of 16 Sydney Local Health District Royal Prince Alfred Hospital Guideline No: RPAH_GL2013_019 September 2016 include a complete ‘head to toe to back’ inspection of the baby as detailed below in Figure 2. The findings should be documented in the relevant section of the NCPOC. 3.2 Oxygen saturation screening: In the first minutes of life, there is a transition from the placenta being the main organ of gas exchange to the newborn lungs. Toth1 et al demonstrated in 50 healthy newborns that it takes between 12 and 14 minutes to achieve saturations > 95%. Routine oxygenation saturation screening of well newborns has been shown to improve early diagnosis of congenital heart disease (CHD)2 with a low false positive rate and minimal impact on resources. About half of the babies with a low saturation screen (<95%) will have either congenital heart disease (~1/3rd) or other significant pathologies which include respiratory disease, delayed transition to extra-uterine life (persistent pulmonary hypertension of the newborn), sepsis or metabolic conditions (~2/3rd)3. Saturation measurement within the first 4 to 6 hours of birth has a lower accuracy for detection of CHD but greater sensitivity for non-cardiac pathology while screening after 24 hours (late screen) has greater sensitivity for detection of CHD, especially left heart ductal dependent lesions. At RPAH, both early and late oxygen saturation screening will be performed in accordance with the existing guideline. 3.2.1 How to perform oxygen saturation screening: Early oxygen saturation screening will be performed in accordance with the existing guideline Perform screening when the infant is quiet. Place the probe around one foot with light source and receiver on each side of foot. Secure with Coban® tape. To ensure good blood flow to the foot, do not secure too tightly and do not hold the probe around the foot. Switch on oximeter and allow signal to stabilise. Read when stabilised and there is a good plethysmographic light pulse. 3.3 Anthropometry Newborn measurement of weight, length, and head circumference reflects fetal nutrition and forms the basis on which future growth measurements. 4,5,7,8 3.3.1 How to measure weight: The scales on the Pea Pod are used for accurate measurement of weight to the nearest gram. The newborn is bare weighed. The weight percentile is calculated using the Beeby electronic calculator on the computer in the NEAP room, or if unavailable the weight is plotted on New South Wales population-based birthweight percentile charts (less accurate)9. 3.3.2 How to measure length: The length-board measurement, infantometer, has been shown to be the most reliable and accurate measurement of neonatal length 6,10,11 and more recent designs have improved ease of use such as the Easy-Glide Bearing Infantometer (Perspective Enterprises, Portage, MI, USA). The neonate is placed supine and unclothed on the board and held gently with his or her body aligned and head in a neutral position. One person stands at the top of the length board and holds the baby’s head in contact with the headboard while another Compliance with this Guideline is recommended Page 4 of 16 Sydney Local Health District Royal Prince Alfred Hospital Guideline No: RPAH_GL2013_019 September 2016 extends the left leg by placing the hand over the left knee, depressing the knee, straightening the leg and moving the footboard to touch the plantar surface of the foot at a right angle to the leg. Recheck that the head has not moved from the headboard before taking the measurement. The actual reading is marked by an arrow as there is an offset for greater ease of reading and accuracy. The length percentile is calculated using the Beeby electronic calculator on the computer in the NEAP room or plotted on New South Wales population-based birth length percentile charts9 (less accurate). . 3.3.3 How to measure head circumference: Head circumference is measured using disposable paper circumference tapes at the maximum fronto-occipital circumference. Two reproducible measurements are required. The head circumference percentile is calculated using the Beeby electronic calculator on the computer in the NEAP room or plotted on New South Wales population-based birth head circumference percentile charts9 (less accurate). 3.4 Body composition - Fat measurement (fat mass, fat free mass and body fat %) Accurately determining the nutritional status of newborns is a major public health problem. Furthermore undernourished neonates that survive are at risk of long term health outcomes, including hypertension, stroke, type 2 diabetes, obesity and cardiovascular disease. 12,13 Neonatal undernutrition or ‘wasting’ is a clinical diagnosis often characterised by diminished subcutaneous tissues and underlying muscles with loose wrinkled skin of the arms, thighs, elbows and knees. However this clinical sign is, in our experience at RPAH, not well recognised by a range of health providers. Thus defining who is undernourished is problematic. Conventional approaches include the use of population based percentiles (< 3rd , 5th or 10th percentiles) or customised growth charts. Population based charts rely on a large cross section of neonates and use weight for gestational age by sex. Customised charts account for more maternal variables, however there is not strong evidence to support their use at present. 14,15 An alternative to birth weight is the use of body composition or body fat % (BF%). The wasted, undernourished newborn is characterised by loss of the normal fat accretion in the last 4-6 weeks of pregnancy. As fat is used by the newborn as an alternative substrate to glucose for brain metabolism, BF% is a potentially very useful measure indicating degree of undernutrition and directly related to neonatal metabolic outcomes. The additional advantage is that it can distinguish the normal fat SGA (weight less than 10th percentile) from the low fat, undernourished SGA newborn and define the low fat AGA newborn at high risk of hypoglycaemia, currently not possible with any other methods. Recently a new technology using air displacement plethysmography (ADP) has become available to non-invasively, accurately and quickly measure BF% in infants from birth to 6 months of age. ADP has been validated against the four-compartment model and biological and physical phantoms16,17 and is considered the criterion method for determining BF% in neonates. 18-22 Several studies have investigated the BF% as an indicator of neonatal nutritional status using ADP. 20-25 Body fat is a better measure than customised charts for assessing neonatal morbidity and as good as population based charts.26 The advantage of this method is it is Compliance with this Guideline is recommended Page 5 of 16 Sydney Local Health District Royal Prince Alfred Hospital Guideline No: RPAH_GL2013_019 September 2016 accurate, easy, reliable, non-invasive and acceptable to parents. The cut offs for low and high fat are shown in the flow chart. These were determined by significantly better Receiver Operator Curves (ROCs) for combined morbidity assessed by 3 pre-specified outcomes (temp <36.5C, prolonged hospital stay, poor feeding (2 of 3 objective criteria). The cut off was determined by the highest sensitivity balanced by the best specificity. 26 3.4.1 How to measure body composition: This is performed in the NEAP room just after the measurement of length and weight using the PeaPod (CosMed, USA). Compliance with this Guideline is recommended Page 6 of 16 Sydney Local Health District Royal Prince Alfred Hospital Guideline No: RPAH_GL2013_019 September 2016 Figure 1 - Overview on performing the NEAP Compliance with this Guideline is recommended Page 7 of 16 Sydney Local Health District Royal Prince Alfred Hospital Guideline No: RPAH_GL2013_019 September 2016 Figure 2 - Early Physical Examination of the Newborn Baby The routine newborn assessment should include all aspects of the checklist on page 1 of the NCPOC. The schema below moves from head to toe, front to back (adapted from Queensland Maternity and Newborn Clinical Guidelines Program 61)27. This examination does not replace the discharge check which will include the red reflex, the heart and the hips. General Head Face Check: Skin & Colour Symmetrical Proportioned Palpate: Sutures Fontanelle Trauma (check sub-galeal haemorrhage) Inspect: Morphology Eyes, Ears Nose, Jaw Mouth Visualise and feel palate (hard and soft) Chest Check: Respiratory rate No recession Palpate neck Abdomen Anogenital Limbs Back Compliance with this Guideline is recommended Check: No distension Palpate for masses Umbilicus Umbilical vessels (x3) Check normal: External genitalia Anus patency, appearance and position Check normal: Hands and Feet Digits Movements Check in ventral suspension: Straight spine No skin markings over spine Page 8 of 16 Sydney Local Health District Royal Prince Alfred Hospital Guideline No: RPAH_GL2013_019 September 2016 Figure 3 - Physical examination referral pathway Compliance with this Guideline is recommended Page 9 of 16 Sydney Local Health District Royal Prince Alfred Hospital Guideline No: RPAH_GL2013_019 September 2016 Figure 4 - Pea Pod Quick Reference User Guide Compliance with this Guideline is recommended Page 10 of 16 Sydney Local Health District Royal Prince Alfred Hospital Guideline No: RPAH_GL2013_019 September 2016 Figure 5 - Anthropometry referral pathway Compliance with this Guideline is recommended Page 11 of 16 Sydney Local Health District Royal Prince Alfred Hospital Guideline No: RPAH_GL2013_019 September 2016 Figure 6 - Oxygen Saturation referral pathway Compliance with this Guideline is recommended Page 12 of 16 Sydney Local Health District Royal Prince Alfred Hospital Guideline No: RPAH_GL2013_019 September 2016 Figure 7 – Body fat percentage referral pathway Compliance with this Guideline is recommended Page 13 of 16 Sydney Local Health District Royal Prince Alfred Hospital Guideline No: RPAH_GL2013_019 September 2016 4. Key Points Key point Level of Evidence & Recommendation (NHMRC)25 Air displacement plethysmography (ADP) non- Level of evidence: 3 invasively, accurately and quickly measures BF% in infants from birth to 6 months of age. Strength of recommendation: A Level of evidence: 3 Body fat is a better measure than customised charts for assessing neonatal morbidity Strength of recommendation: A 5. References 1. Toth B, Becker A, Seelbach-Gobel B. Oxygen saturation in healthy newborn infants immediately after birth measured by pulse oximetry. Arch Gynecol Obstet 2002 April: 266 (2)105-107 2. A. Meberg, A. Andreassen, L. Brunvand, T. Markestad, D. Moster, L. Nietsch, I. E. Silberg, and J. E. Skålevik, 'Pulse Oximetry Screening as a Complementary Strategy to Detect Critical Congenital Heart Defects', Acta Pædiatrica, 98 (2009), 682-86. 3. A. Meberg, S. Brugmann-Pieper, R. Due, Jr., L. Eskedal, I. Fagerli, T. Farstad, D. H. Froisland, C. H. Sannes, O. J. Johansen, J. Keljalic, T. Markestad, E. A. Nygaard, A. Rosvik, and I. E. Silberg, 'First Day of Life Pulse Oximetry Screening to Detect Congenital Heart Defects', J Pediatr, 152 (2008), 761-5. 4. T. S. Johnson, J. L. Engstrom, and D. K. Gelhar, 'Intra- and Interexaminer Reliability of Anthropometric Measurements of Term Infants', J Pediatr Gastroenterol Nutr, 24 (1997), 497-505. 5. T. S. Johnson, J. L. Engstrom, J. A. Warda, M. Kabat, and B. Peters, 'Reliability of Length Measurements in Full-Term Neonates', J Obstet Gynecol Neonatal Nurs, 27 (1998), 270-6. 6. A. J. Wood, C. H. Raynes-Greenow, A. E. Carberry, and H. E. Jeffery, 'Neonatal Length Inaccuracies in Clinical Practice and Related Percentile Discrepancies Detected by a Simple Length-Board', J Paediatr Child Health, 49 (2013), 199-203. 7. T. H. Lipman, K. D. Hench, T. Benyi, J. Delaune, K. A. Gilluly, L. Johnson, M. G. Johnson, H. McKnight-Menci, D. Shorkey, J. Shults, F. L. Waite, and C. Weber, 'A Multicentre Randomised Controlled Trial of an Intervention to Improve the Accuracy of Linear Growth Measurement', Arch Dis Child, 89 (2004), 342-6. 8. T. H. Lipman, K. D. Hench, J. D. Logan, D. A. DiFazio, P. M. Hale, and C. SingerGranick, 'Assessment of Growth by Primary Health Care Providers', Journal of Pediatric Health Care, 14 (2000), 166-71. Compliance with this Guideline is recommended Page 14 of 16 Sydney Local Health District Royal Prince Alfred Hospital Guideline No: RPAH_GL2013_019 September 2016 9. P. J. Beeby, T. Bhutap, and L. K. Taylor, 'New South Wales Population-Based Birthweight Percentile Charts', J Paediatr Child Health, 32 (1996), 512-8. 10. D. P. Davies, and R. E. Holding, 'Neonatometer: A New Infant Length Measurer', Arch Dis Child, 47 (1972), 938-40. 11. A. F. Roche T. G. Lohman, & R. Martorell (eds.), Anthropometric Standardization Reference Manual (Champaign, IL: Human Kinetics Books, 1988). 12. D. J. Barker, J. G. Eriksson, T. Forsen, and C. Osmond, 'Fetal Origins of Adult Disease: Strength of Effects and Biological Basis', Int J Epidemiol, 31 (2002), 1235-9. 13. J. C. Wells, S. Chomtho, and M. S. Fewtrell, 'Programming of Body Composition by Early Growth and Nutrition', Proc Nutr Soc, 66 (2007), 423-34. 14. A. E. Carberry, A. Gordon, D. M. Bond, J. Hyett, C. H. Raynes-Greenow, and H. E. Jeffery, 'Customised Versus Population-Based Growth Charts as a Screening Tool for Detecting Small for Gestational Age Infants in Low-Risk Pregnant Women', in Cochrane Database of Systematic Reviews John Wiley & Sons, Ltd 2011 ). 15. A. E. Carberry, C. H. Raynes-Greenow, R. M. Turner, and H. E. Jeffery, 'Customized Versus Population-Based Birth Weight Charts for the Detection of Neonatal Growth and Perinatal Morbidity in a Cross-Sectional Study of Term Neonates', American Journal of Epidemiology, August 21 (2013).. 16. A. Frondas-Chauty, I. Louveau, I. Le Huerou-Luron, J. C. Roze, and D. Darmaun, 'AirDisplacement Plethysmography for Determining Body Composition in Neonates: Validation Using Live Piglets', Pediatric research, 72 (2012), 26-31. 17. K. J. Ellis, M. Yao, R. J. Shypailo, A. Urlando, W. W. Wong, and W. C. Heird, 'BodyComposition Assessment in Infancy: Air-Displacement Plethysmography Compared with a Reference 4-Compartment Model', Am J Clin Nutr, 85 (2007), 90-5. 18. G. Ma, M. Yao, Y. Liu, A. Lin, H. Zou, A. Urlando, W. W. Wong, L. NommsenRivers, and K. G. Dewey, 'Validation of a New Pediatric Air-Displacement Plethysmograph for Assessing Body Composition in Infants', Am J Clin Nutr, 79 (2004), 653-60. 19. A. Urlando, P. Dempster, and S. Aitkens, 'A New Air Displacement Plethysmograph for the Measurement of Body Composition in Infants', Pediatr Res, 53 (2003), 486-92. 20. M. Yao, L. Nommsen-Rivers, K. Dewey, and A. Urlando, 'Preliminary Evaluation of a New Pediatric Air Displacement Plethysmograph for Body Composition Assessment in Infants', Acta Diabetol, 40 Suppl 1 (2003), S55-8. 21. G.S. Andersen, T. Girma, J.C.K. Wells, P. Kæstel, K.F. Michaelsen, and H. Friis, 'Fat and Fat-Free Mass at Birth: Air Displacement Plethysmography Measurements on 350 Ethiopian Newborns', Pediatr Res, 70 (2011), 501-06. 22. D.A. Fields, J.M. Gilchrist, P.M. Catalano, M.L. Giannì, P.M. Roggero, and F. Mosca, 'Longitudinal Body Composition Data in Exclusively Breast-Fed Infants: A Multicenter Study', Obesity, 19 (2011), 1887-91. 23. B. E. Lingwood, A. M. Storm van Leeuwen, A. E. Carberry, E. C. Fitzgerald, L. K. Callaway, P. B. Colditz, and L. C. Ward, 'Prediction of Fat-Free Mass and Percentage of Body Fat in Neonates Using Bioelectrical Impedance Analysis and Anthropometric Measures: Validation against the Pea Pod', Br J Nutr, 107 (2012), 1545-52. Compliance with this Guideline is recommended Page 15 of 16 Sydney Local Health District Royal Prince Alfred Hospital Guideline No: RPAH_GL2013_019 September 2016 24. P. Roggero, M. L. Gianni, O. Amato, P. Piemontese, D. Morniroli, W. W. Wong, and F. Mosca, 'Evaluation of Air-Displacement Plethysmography for Body Composition Assessment in Preterm Infants', Pediatric research, 72 (2012), 316-20. 25. A. Fields, P. B. Higgins, and D. Radley, 'Air-Displacement Plethysmography: Here to Stay', Curr Opin Clin Nutr Metab Care, 8 (2005), 624-9. 26. A. E. Carberry, C. H. Raynes-Greenow, R. M. Turner, L. M. Askie, and H. E. Jeffery, 'Is Body Fat Percentage a Better Measure of Undernutrition in Newborns Than Birth Weight Percentiles', Pediatric Research, Advance online publication 02 October (2013). 27. Queensland Maternity and Neonatal Clinical Guidelines Program, 'Examination of the Newborn Baby', ed. by Queensland Health (Queensland Queensland Health, 2009). Compliance with this Guideline is recommended Page 16 of 16
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