Carcinogenesis
VOLUME 37, NUMBER 3
March 2016
Contents
review
Mucins and Wnt/β-catenin signaling in gastrointestinal cancers: an unholy nexus
Priya Pai, Satyanarayana Rachagani, Punita Dhawan, and Surinder K.Batra . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223
Biology, Genetics and Epigenetics
Dehydroepiandrosterone triggers autophagic cell death in human hepatoma cell line
HepG2 via JNK-mediated p62/SQSTM1 expression
Rolando Vegliante, Enrico Desideri, Luca Di Leo, and Maria Rosa Ciriolo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 233
Cancer Biomarkers and Molecular Epidemiology
MicroRNA profiles in colorectal carcinomas, adenomas and normal colonic mucosa:
variations in miRNA expression and disease progression
Martha L.Slattery, Jennifer S.Herrick, Daniel F.Pellatt, John R.Stevens, Lila E.Mullany, Erica Wolff,
Michael D.Hoffman, Wade S.Samowitz, and Roger K.Wolff . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 245
Intracellular location of BRCA2 protein expression and prostate cancer progression in
the Swedish Watchful Waiting Cohort
Tryggvi Thorgeirsson, Kristina M.Jordahl, Richard Flavin, Mara Meyer Epstein, Michelangelo Fiorentino,
Swen-Olof Andersson, Ove Andren, Jennifer R.Rider, Juan Miguel Mosquera, Helen Ingoldsby, Katja Fall,
Laufey Tryggvadottir, and Lorelei A.Mucci . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 262
Genetic determinants of CYP2A6 activity across racial/ethnic groups with different risks of
lung cancer and effect on their smoking intensity
Sungshim L.Park, Maarit I.Tiirikainen, Yesha M.Patel, Lynne R.Wilkens, Daniel O.Stram,
Loic Le Marchand, and Sharon E.Murphy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 269
Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta-analysis
of 14 463 cases and 44 188 controls
Xiaozheng Kang, Hongliang Liu, Mark W.Onaitis, Zhensheng Liu, Kouros Owzar, Younghun Han, Li Su,
Yongyue Wei, Rayjean J.Hung, Yonathan Brhane, John McLaughlin, Paul Brennan, Heike Bickeböller,
Albert Rosenberger, Richard S.Houlston, Neil Caporaso, Maria Teresa Landi, Joachim Heinrich,
Angela Risch, Xifeng Wu, Yuanqing Ye, David C.Christiani, Christopher I.Amos, and Qingyi Wei . . . . . . . . . . . . 280
Inflammation, Microenvironment and Prevention
Na+/H+ exchanger 1, Na+/Ca2+ exchanger 1 and calmodulin complex regulates interleukin
6-mediated cellular behavior of human hepatocellular carcinoma
Jingyu Xu, Bei Ji, Guorong Wen, Yuan Yang, Hai Jin, Xuemei Liu, Rui Xie, Wenfeng Song,
Penghong Song, Hui Dong, and Biguang Tuo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 290
Low doses of gamma irradiation potentially modifies immunosuppressive tumor
microenvironment by retuning tumor-associated macrophages: lesson from insulinoma
Hridayesh Prakash, Felix Klug, Vinod Nadella, Varadendra Mazumdar, Hubertus Schmitz-Winnenthal,
and Liudmila Umansky . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 301
Carcinogenesis
Ethanol and 4-methylpyrazole increase DNA adduct formation of furfuryl alcohol in FVB/N
wild-type mice and in mice expressing human sulfotransferases 1A1/1A2
Benjamin Sachse, Walter Meinl, Hansruedi Glatt, and Bernhard H.Monien . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 314
PSCA acts as a tumor suppressor by facilitating the nuclear translocation of RB1CC1
in esophageal squamous cell carcinoma
Li-Yi Zhang, Jian-Lin Wu, Hai-Bo Qiu, Sui-Sui Dong, Ying-Hui Zhu, Victor Ho-Fun Lee, Yan-Ru Qin,
Yan Li, Juan Chen, Hai-Bo Liu, Jiong Bi, Stephanie Ma, Xin-Yuan Guan, and Li Fu . . . . . . . . . . . . . . . . . . . . . . . . 320
The feedback loop between miR-124 and TGF-β pathway plays a significant role in non-small
cell lung cancer metastasis
Lidong Zu, Yunjing Xue, Jinglong Wang, Yujie Fu, Xiumin Wang, Gang Xiao, Mingang Hao, Xueqing Sun,
Yingying Wang, Guohui Fu, and Jianhua Wang . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 333
Erratum ������������������������������������������������������������������������������������������������������������������������������������������������������������������344