Aqua GG® (Glyceryl glucoside)
INCI/Chemical Name
Product Specifications
Glyceryl glucoside
2-O-α-D-Glucopyranosylglycerine
CAS Number
22160-26-5
Features & Benefits
·Aqua GG® is glyceryl glucoside (2-GG), a natural substance
present in Japanese rice wine (sake) and other fermented
Appearance
Slight yellowish liquid
Contents
65% Glyceryl glucoside,
5% glycerine, 30% Water
1
H NMR spectrum
Conforms to structure
Mass spectrum
Conforms to structure
Recommended dosage
0.5 - 2.0%
pH (2% in water)
4.5 - 6.0
Storage condition
Below 25℃
Shelf life
1 year, no preservatives
Pack sizes
5 kg, 10 kg
E.coli/ Salmonella
Negative
Production process
Enzymatic synthesis
foods.
·2-GG is a reactivation and revitalization substance of
resurrection plant, Myrothamnus flabellifolia.
Biological activity
·Topical application of 2-GG increases dermal insulin-like
growth factor-I (IGF-I) via activation of sensory neurons.2
·2-GG stimulates the development of new aquaporins
(AQPs) in the skin cells. AQPs control water transfer into
and out of the cells.3, 4
Moisture comparison
test of HA and 2-GG
in in vivo model using
PIE MC-1000.
·2-GG decreases transepidermal water loss enhancing barrier function.1
·2-GG increases secretion of sweat in the facial skin epidermis.2
·Aqua GG® is 100% natural, free of TSE/BSE and does not
contain GMO.
References.
1. J. Clin. Aesthet. Dermatol. 2012;5(8): 29–39.
2. Biosci. Biotechnol. Biochem. 2010; 74(4), 759–765.
3. Skin Pharmacol. Physiol. 2012; 25: 192–199.
Fluorescence images showing overexpression of AQP3 pro-
4.http://www.eucerin.co.uk/our-research/behind-the-sci-
tein in HaCaT cells when treated with 1% 2-GG for 24 h. Cell
ence/
nuclei (Blue), target AQP3 protein (Green).
(Source: INCOSPHARM, Korea).
GeneChem Inc.
26-69, Gajeongbuk-ro, Yuseong-gu, Daejeon, 34113, Rep. of Korea
Tel. +82-42-360-0872~4 Fax. +82-42-360-0875 E-mail. [email protected]
Siallac® (Sialyllactose)
Chemical Name
Product Specifications
3′-N-Acetylneuraminyl-lactose sodium salt
(2,3-Sialyllactose, 3′-SL )
6′-N-Acetylneuraminyl-lactose sodium salt
(2,6-Sialyllactose, 6′-SL)
Mol. Formula/ Weight
C23H38NO19Na / 655.53 g/mol
CAS Number
35890-38-1
Appearance
White to Off-white powder
Purity (HPLC)
≥ 95%
1
H NMR spectrum
Conforms to structure
Mass spectrum
Conforms to structure
Solubility
Approx. 60% (Room temp.)
Recommended dosage
0.02 - 0.1%
Moisture
＜ 6%
Sodium
＜ 3.5%
E.coli / Salmonella
Negative
Shelf life
2 years
Pack sizes
Kg
Storage condition
Room temp.
Production process
Enzymatic reaction
Features & Benefits
·Sialyllactoses (SLs) are biologically important oligosaccharides (HMO) abundant in mother’s milk.
·SLs are known to regulate inflammatory responses and
treating skin irritation.3
·SLs are reported to prevent or treat the hypertropic scar
or keloid.5
·Studies have shown that combination of SLs reduces the
hyperpigmentation of skin and effectively treats atopic dermatitis and eczema.1, 2, 3, 4
·Many global cosmetic companies have been using SLs in
their premium grade of products (cleanser, moisturizer,
eye make-up remover and facial mask products).
References.
1. Arch Dis Child. 2006 Oct; 91(10): 814–819.
2. Glycoconj J. 2015 Jul; 32(6): 413-420.
3. Patent # WO 2012076321A1
4.Patent # WO2014138578A1, Yale University.
5.US Patent # 8,877,736 B2.
GeneChem Inc.
HPLC chromatogram
showing purity of 3′-SL.
GeneChem’s SL products
26-69, Gajeongbuk-ro, Yuseong-gu, Daejeon, 34113, Rep. of Korea
Tel. +82-42-360-0872~4 Fax. +82-42-360-0875 E-mail. [email protected]
Diguanosine tetraphosphate (GP4G)
INCI Name
Product Specifications
Artemia extract
Chemical Name
Diguanosine tetraphosphate (GP4G)
CAS Number
Appearance
Powder
Odour
Characteristic odour
pH (25℃)
5.0 - 7.0
Molecular weight
868.39
Molecular formula
C20H28N10O21P4
Purity (HPLC)
≥ 90%
1
H NMR spectrum
Conforms to structure
Mass spectrum
Conforms to structure
E.coli / Salmonella
Negative
Storage condition
2 - 8℃
Production process
Enzymatic reaction
79202-52-1
Biological activity
Features & Benefits
·GP4G is a unique plankton (Artemia salina) extract that
helps protect skin from environmental shocks, such as
extreme pH, temperature change, UV and IR exposure.3, 4
·GP4G is known as a cellular energizer and revitalizer that
increases ATP.2, 3
·GP4G has been reported to stimulate protein synthesis, reduces stress-induced DNA damage, increases number of
papilla cells and hair length.1, 2, 3
·GP4G increases HSP70 expression, atones for age-related decrease in HSP70, and helps restore the decrease in
HSP70 caused by retinoids.3
·GP4G produced by GeneChem using enzymatic reaction is
free of TSE/BSE and does not contain GMO.
Skin treated with placebo
Skin treated with 3% GP4G
GP4G induces HSP70 protein expression in ex vivo human
skin culture. (Source: ISP Vincience Global Skin Research
Center).
References.
1. Patent US 20060029563 A1.
2. J. Cosmet. Sci. 2011, 62(5): 469-482.
3. http://www.ashland.com/products/gp4g-sp-biofunctional
4. Patent US 20100129299 A1.
GeneChem Inc.
26-69, Gajeongbuk-ro, Yuseong-gu, Daejeon, 34113, Rep. of Korea
Tel. +82-42-360-0872~4 Fax. +82-42-360-0875 E-mail. [email protected]
Tocopherol-G (α-Tocopheryl glucoside)
INCI/Chemical Name
Product Specifications
Tocopheryl glucoside
α-tocopheryl 6-O-β-D-glucopyranoside
Features & Benefits
·Various tocopherol derivatives are used in cosmetics as
antioxidant and skin conditioning agents.
·Tocopheryl glucoside is more soluble, stable and easily
transported into the skin in comparison with tocopherol.3, 4
·Tocopheryl glucoside soothes the skin and protects lipids.
·Tocopheryl glucoside has been reported to prevent and
CAS No.
Not available
Molecular weight
592.85
Molecular formula
C35H60O7
Purity (HPLC)
≥ 90%
1
H NMR spectrum
Conforms to structure
Mass spectrum
Conforms to structure
Storage condition
2-8℃
Production process
Enzymatic reaction
treat atopic and contact dermatitis.1
·Tocopheryl glucoside protects skin against UV-induced
References.
damage.2
·Studies have revealed that tocopheryl glucoside converts
1. Patent # EP 0452507 A1.
progressively to active tocopherol in skin over several
2. FEBS Lett. 1997; 401(2-3):167-170.
hours with anti-inflammatory and antioxidant effects, pro-
3. Carbohydr. Res. 2000, 325, 72-80.
tecting collagen and elastin.4, 5
4. Chem. Pharm. Bull. 2001, 49, 948-953.
·Tocopherol-G produced by GeneChem is free of TSE/BSE
and 100% natural.
5. J. Control. Release 2004. 100(2): 221-231.
Chemical Structure
Tocopheryl glucoside
GeneChem Inc.
26-69, Gajeongbuk-ro, Yuseong-gu, Daejeon, 34113, Rep. of Korea
Tel. +82-42-360-0872~4 Fax. +82-42-360-0875 E-mail. [email protected]