August 30, 2013 Avery, McCarty, and MacLeod were giants in the field of genetics research. In the 1940s, they tried to explain a strange phenomena: When they killed lethal (deadly) strep bacteria and mixed them with nonlethal strep bacteria, the nonlethal strain became deadly. And this now-deadly strain had offspring that were all lethal as well. What substance changed the nonlethal bacteria into lethal bacteria? Avery, McCarty, and MacLeod carried out the following experiment: They heat-killed a sample of lethal bacteria, then divided it into 2 parts. In one of the parts, they destroyed all the protein. In the other, they destroyed all the DNA. Then they mixed each part with nonlethal bacteria and injected the samples into mice. The mice injected with the protein-free sample died. The mice injected with the DNA-free sample lived 1. What question were they testing? 2. What was the independent variable? 3. What was the dependent variable? 4. What variables did they need to control in the experiment? 5. What could they infer/conclude from their result? (en.wikipedia.org) key: = nonlethal bacteria n = bacteria ★ = killed lethal bacteria without DNA u = killed lethal bacteria without protein August 30, 2013 August 30, 2013 8/30 discussing "mouse" handout on Avery, McCarty, & MacLeod August 30, 2013 8/30 discussing "mouse" handout on Avery, McCarty, & MacLeod August 30, 2013 8/30 discussing "mouse" handout on Avery, McCarty, & MacLeod August 30, 2013
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