VNA Level II Module 8: Therapeutic Nutrition Lower Learning Objectives Urinary Tract Disease Learning Objectives After completing this module, your basic understanding should include: • What the lower urinary tract does and how disease affects its function. • Ways dietary mineral intake and other factors may predispose pets to urine crystals and urinary stones. • How intervention with nutritional aids such as Hill’s® Prescription Diet® s/d® Canine, c/d® Canine, u/d® Canine, s/d® Feline and c/d® Multicare Feline may help manage crystals and stones in the urinary tract. • The features and benefits of Hill’s Prescription Diet brand products for lower urinary tract disorders. • Your vital role in promoting proper pet nutrition, as a way to help enrich and lengthen the special relationship between people and their pets. Your progress is saved. Slide 1 of 24 Introduction VNA Level II Module 8: Therapeutic Nutrition Lower Urinary Tract Disease Introduction Lower urinary tract diseases, (LUTD) are commonly seen in pets brought into veterinary practices, and as such, are of concern to dog and cat owners, as well as the veterinary health care team. Painful urination, blood in the urine, frequent attempts to urinate, vocalization while urinating, and urinating in inappropriate locations are common reasons why affected pets are presented. There are many causes of LUTD, ranging from bacterial infections, urolithiasis (formation of stones in the urinary tract), urethral obstruction (partial to complete blockage of the outflow tract from the bladder), anatomic defects, prostate disease, cancer, trauma, etc. Our focus here though, will be mainly on urinary tract stones (also called uroliths or calculi) and urethral plugs, two categories that may often respond well to nutritional therapy. Signs of LUTD include painful urination, blood in the urine, frequent attempts to urinate, vocalization while urinating, and urinating in inappropriate locations. Because certain types of LUTD tend to recur, proper nutrition is a critical element for managing these conditions in dogs and cats. Furthermore, nutrient requirements may differ from one pet to another depending on the mineral composition of crystals or stones in the urinary tract. This module will help you communicate effectively with clients whose pets have LUTD, with an emphasis on proper use of Hill’s® Prescription Diet® products. Your progress is saved. Slide 2 of 24 VNA Level II Module 8: The Lower Urinary Tract Therapeutic Nutrition Lower Urinary Tract Disease The Lower Urinary Tract A pet’s urinary tract consists of two kidneys, two ureters that connect the kidneys to the bladder, the bladder, and the urethra, the tube through which urine leaves the body. The kidneys and ureters comprise the upper urinary tract. The bladder and urethra comprise the lower urinary tract. Figure 1. The dog and cat urinary tract consists of two kidneys, two ureters, a urinary bladder and a urethra. The lower urinary tract functions to store and periodically release urine. The urinary tract functions so that urine generally only flows one-way, from the kidneys, down the ureters, into the bladder, and out the body through the urethra. The urinary bladder and the urethra comprise the “lower urinary tract”. Your progress is saved. Slide 3 of 24 VNA Level II Module 8: The Lower Urinary Tract Therapeutic Nutrition Lower Urinary Tract Disease The Lower Urinary Tract The urinary system is designed to produce, store and periodically release urine, (body wastes in a soluble, [liquid] form). Urine typically contains a number of substances that are removed from the blood by the kidneys to try and maintain body health. Among these substances are the breakdown products of protein metabolism and excess minerals such as sodium, chloride, phosphorus (also called phosphate), potassium, and others. Urine also contains substances that usually inhibit minerals from forming crystals and crystals from adhering to one another to form stones. Urine is usually composed of about 95% water. However, the water content of urine varies depending on how much water is in the body. Dehydrated pets and pets with reduced water intake produce more concentrated urine. In general, cats produce more concentrated urine than dogs. Urine concentration of soluble components is important. For example, minerals that form crystals are more dispersed in dilute urine; thus are less likely to form crystals and stones. Urine is mostly composed of water, but also contains breakdown products of protein metabolism and excess minerals, (which are excreted in the urine to maintain body health). It is important to make sure that all pets have access to fresh, clean water, and that they are consuming appropriate amounts each day, (through the food, usually canned), and from drinking water. Your progress is saved. Slide 4 of 24 VNA Level II Module 8: Urine Crystals and Stones Therapeutic Nutrition Lower Urinary Tract Disease Urine Crystals and Stones The formation of stones in the urinary tract is called “urolithiasis”. Urinary stones, (uroliths) may form in any part of the urinary tract. Most of these, however, develop in the urinary bladder, since the bladder serves as a reservoir for urine accumulation. Uroliths form when urine is oversaturated with waste products, (minerals) that are able to crystallize into stones and/or when the substances that naturally inhibit stone formation are deficient or ineffective. Urinary stone formation is complex and involves many factors, many of which are not yet completely understood. Some factors thought to be involved include increased urinary levels of minerals (stone components), metabolic influences (some uroliths occur because of metabolic problems), ingestion and intestinal absorption of minerals, urine pH, and presence of urinary tract infections. Microscopic, (can’t be seen without the aid of a microscope) precipitates in urine are called crystals. Stones are macroscopic precipitates; that is, they can be seen without the aid of a microscope. Figure 2. Photomicrographs of common crystals found in urine sediment. Source: Small Animal Clinical Nutrition, 4th Edition. Your progress is saved. Slide 5 of 24 VNA Level II Module 8: Urine Crystals and Stones Therapeutic Nutrition Lower Urinary Tract Disease Urine Crystals and Stones Uroliths may pass through various parts of the urinary tract, dissolve, enlarge, or become inactive (no additional formation occurs). Small uroliths may enter from the urinary bladder into the urethra of male and female dogs when they urinate. Female dogs, because of their relatively shorter and wider urethra, are often able to pass these stones without difficulty. Uroliths may obstruct the urethra of male dogs partially or completely, thereby compromising or preventing urine flow. Urethral plugs may similarly obstruct urine flow in male cats. Urethral plugs are usually composed of urine crystals and a substance called matrix. Complete obstruction of the urethra is always considered a medical emergency. Figure 3. Different mineral types of canine uroliths illustrating common sizes, shapes and surface characteristics. Source: Small Animal Clinical Nutrition, 4th Edition. Figure 4. A cross-section of a matrix-crystalline urethral plug. This phenomenon is analogous to a gelatin salad that contains various fruits or vegetables (i.e., crystals, cells, cellular material) embedded in a gelatin matrix. Source: Small Animal Clinical Nutrition, 4th Edition. Figure 5. Complete obstruction of the urethra is considered a medical emergency. Source: Small Animal Clinical Nutrition, 4th Edition. Your progress is saved. Slide 6 of 24 VNA Level II Module 8: Urine Crystals and Stones Therapeutic Nutrition Lower Urinary Tract Disease Urine Crystals and Stones Many pets with risk factors such as metabolic defects or uncontrolled urinary tract infections have recurrent episodes of urolithiasis. The mineral composition of uroliths is especially important and is the basis for most medical management. A brief description of the most common types of uroliths follows. Calcium oxalate is the most common urolith in older cats. Struvite is the most common urolith in dogs and younger cats. Struvite, (magnesium-ammonium-phosphate) is the most common urolith in dogs and younger cats. Struvite uroliths occur in dogs often in conjunction with urinary tract infections. More alkaline or less acidic urine and high magnesium levels in the food are risk factors (see below). Calcium oxalate is the most common urolith of older cats, and the second most common urolith in dogs. More acidic urine favors the precipitation of calcium oxalate. Figure 6. Struvite uroliths are the most common stone seen in dogs and younger cats. Source: Hill’s® Atlas of Veterinary Clinical Anatomy. Figure 7. Calcium oxalate uroliths are the most common type seen in older cats. Source: Hill’s® Atlas of Veterinary Clinical Anatomy. Your progress is saved. Slide 7 of 24 VNA Level II Module 8: Urine Crystals and Stones Therapeutic Nutrition Lower Urinary Tract Disease Urine Crystals and Stones Ammonium urate is a less common urolith in cats and dogs. Dalmatian and English bulldogs have significantly higher incidence of these uroliths, as do cats and dogs with certain blood vessel abnormalities in the liver. Cystine uroliths are a less common urolith type that most commonly affects male English bulldogs and dachshunds. A metabolic error that causes increased amounts of the amino acid cystine in urine is responsible for most cystine uroliths. Other stones you may occasionally see in practice include: • Calcium phosphate • Silica • Compound uroliths, (center is composed of one mineral type, whereas the outer layers are composed of another). Figure 8. Ammonium urate uroliths. Source: Hill’s® Atlas of Veterinary Clinical Anatomy. Figure 9. Cystine uroliths. Source: Hill’s® Atlas of Veterinary Clinical Anatomy. Figure 10. Silica uroliths. Source: Hill’s® Atlas of Veterinary Clinical Anatomy. Your progress is saved. Slide 8 of 24 Risk Factors for LUTDVNA Level II Module 8: Therapeutic Nutrition Lower Urinary Tract Disease Risk Factors for LUTD The risk of stones forming in the urinary tract is greatest when there is a high concentration of dissolved minerals in the urine. Foods high in certain minerals can predispose to uroliths (more below) and inadequate water intake increases the risk of uroliths. When a pet is dehydrated or does not consume adequate amounts of water, its kidneys conserve water by producing concentrated urine. Bladder stones may result from a longstanding bacterial urinary tract infection. Urinary tract infections are common in dogs with urolithiasis, especially struvite stones. Urine pH, (how acidic or alkaline the urine is) can affect the development of certain types of bladder stones. Highly acidic urine favors calcium oxalate crystal formation. Less acidic or alkaline urine favors struvite precipitation. Age is also a factor, as depicted in Figure 11. Bacterial urinary tract infections commonly occur in dogs with urolithiasis, thus appropriate diagnosis and treatment of the infection (and stone type) is a critical part of therapy. Figure 11. The relationship between urolith type and age in cats. Note that the struvite urolithiasis occurs more frequently in young cats, whereas calcium oxalate urolithiasis occurs more frequently in older cats. Source: Small Animal Clinical Nutrition, 4th Edition. Your progress is saved. Slide 9 of 24 VNA Level II Module 8: Important Nutritional Factors Therapeutic Nutrition Lower Urinary Tract Disease Important Nutritional Factors Water: Increasing water intake, (and thus urine formation) reduces the time crystal components are in the urine and dilutes urine components that may crystallize. Low urine volume increases the concentrations of all minerals that form uroliths, and thus increases the risk of crystalluria. Many times, this can be mitigated by feeding the appropriate Hills® canned pet food. Cats in particular, when fed canned foods may drink little water, because they consume water in their food. Because of the higher water content, canned foods have lower energy content by weight than dry foods. Since, for the most part, cats eat to satisfy their energy requirement, cats eating canned foods will often ingest more total water than when fed dry food. This is probably also true of dogs. Urine pH: Highly acidic urine favors calcium oxalate crystal formation. Less acidic or alkaline urine favors struvite precipitation. Figure 12. Supersaturation of urine with urolithforming constituents (e.g., calcium, oxalate) results in crystal growth, aggregation and ultimately urolith formation, if the components are retained in the urinary tract. Source: Small Animal Clinical Nutrition, 4th Edition. Your progress is saved. Slide 10 of 24 VNA Level II Module 8: Important Nutritional Factors Therapeutic Nutrition Lower Urinary Tract Disease Important Nutritional Factors Salt (sodium chloride): While supplementing a pet’s regular food with salt can increased water consumption and urine dilution, there are risks to random salt supplementation. For example, excess salt may be associated with calcium oxalate urolithiasis, high blood pressure, decline in kidney function and heart disease. Figure 13. Schematic depicting how increasing amounts of table salt dissolved in water result in under-saturated, metastable and supersaturated solutions. Similar phenomena occur with mineral salts in urine. Source: Small Animal Clinical Nutrition, 4th Edition. Magnesium: High dietary magnesium levels contribute to struvite formation. Calcium and oxalate: Levels should be adjusted in relationship to calcium. Protein: Moderate levels help limit the amount of phosphorus and ammonium available for struvite uroliths. Your progress is saved. Slide 11 of 24 Diagnosis of LUTD VNA Level II Module 8: Therapeutic Nutrition Lower Urinary Tract Disease Diagnosis of LUTD LUTD is usually diagnosed by the veterinarian based on the pet’s history, clinical signs, veterinary physical examination, and results of diagnostic tests. Sometimes, bladder stones can be felt during the physical exam on abdominal palpation. Diagnostic tests frequently performed include urinalysis, urine culture for bacteria, complete blood count, biochemistry tests (primarily for minerals such as calcium), radiographs, and ultrasound. Quantitative analysis (determining the exact mineral composition), of the urolith provides the most diagnostic, prognostic, and therapeutic information. Uroliths should be sent to a qualified diagnostic laboratory for quantitative analysis. Uroliths should always be sent to a qualified laboratory for quantitative analysis. The link below will take you to a pdf file for urolith analysis. The Minnesota Urolith Center at the University of Minnesota College of Veterinary Medicine conducts, at no charge, quantitative urolith analysis, supported in part by an educational grant from Hill’s®. Your progress is saved. Slide 12 of 24 Level II Module 8: Treatment and Prevention ofVNA LUTD Therapeutic Nutrition Lower Urinary Tract Disease Treatment and Prevention of LUTD Depending on their type, uroliths may either be removed physically, (mechanically or surgically) or dissolved. Keep in mind that many urolith types tend to recur after they are removed surgically or dissolved, especially if no other therapy is instituted. Therefore, urolith removal is often only the beginning of therapy; many dogs and cats require preventive measures and follow-up diagnostic tests, (see below). Formulating effective medical therapy for urolith dissolution, (dissolving the urolith in the bladder through use of therapeutic foods and sometimes other therapy) depends on the mineral composition of the urolith. Failure to analyze uroliths quantitatively or otherwise determine the urolith’s mineral composition may lead to incorrect and possibly harmful therapy. Many urolith types tend to recur after they are removed surgically or dissolved. Therefore, urolith removal is often only the beginning of therapy; many dogs and cats require preventive measures and follow-up diagnostic tests. Proper pet nutrition is a prudent key component. Figure 14. Series of radiographs of a 12-year-old spayed female German shepherd crossbred dog, illustrating struvite urolith, (multiple) dissolution with Prescription Diet® s/d® Canine. Sequential radiographs at diagnosis, 58, 97 and 127 days post nutritional therapy respectively. As part of therapy, the antibiotic, ampicillin was also administered. Source: Small Animal Clinical Nutrition, 4th Edition. Your progress is saved. Slide 13 of 24 Level II Module 8: Treatment and Prevention ofVNA LUTD Therapeutic Nutrition Lower Urinary Tract Disease Treatment and Prevention of LUTD As mentioned above, water is a important nutritional factor for urolithiasis. Generally, dogs and cats with uroliths should be encouraged to drink more water during and after treatment for urolithiasis. Feeding the appropriate canned Hills® pet food and placing multiple water bowls throughout the home encourage water consumption, which helps dilute minerals in the urine. Advise owners to always provide fresh, clean water for their pet. Increasing water intake benefits pets with urolithiasis. Feeding the appropriate canned Hill’s® pet food is one approach. Some uroliths are caused by bacterial urinary tract infections or are complicated by infections that develop as a result of the urolith. Urinalysis and urine culture testing are necessary to determine the bacteria involved and which appropriate antimicrobial agents to utilize. Specific nutritional aids and preventive measures for specific urolith types follow. Your progress is saved. Slide 14 of 24 Hill’s® Products Available as Nutritional VNA Level II Module 8: Aids in Treating LUTD:Therapeutic Nutrition Lower Urinary Tract Disease ® Hill’s Products Available as Nutritional Aids in Treating LUTD: CANINE Click here to visit Hill’s Key to Clinical Nutrition Prescription Diet® s/d® Canine Struvite Crystals and Stone Dissolution Prescription Diet® s/d® Canine contains low levels of protein, magnesium and phosphorus, and promotes the formation of a more acidic urine. The nutritional characteristics, (features) have been shown to aid dissolution of struvite crystals and uroliths, (benefit) without the need for surgical intervention. Very low dietary intake of magnesium and phosphorus results in decreased urinary concentrations of struvite building blocks. Very low protein intake and high sodium intake increase urine volume, diluting the concentration of struvite forming constituents in the urine. A more acidic urine pH increases the solubility of struvite crystals aiding in the dissolution of struvite uroliths. Eradicating bacterial urinary tract infections, (continuous antibiotic therapy is recommended during the entire course of dissolution). Monitoring urine pH and urinalysis helps ensure continuously acidic urine for successful treatment. The target urine pH- more acid, (5.9-6.1). Feeding other foods besides and/or in addition to s/d® Canine during the struvite dissolution period may delay or prevent stone dissolution! Your progress is saved. Slide 15 of 24 Hill’s® Products Available as Nutritional VNA Level II Module 8: Aids in Treating LUTD:Therapeutic Nutrition Lower Urinary Tract Disease ® Hill’s Products Available as Nutritional Aids in Treating LUTD: Prescription Diet® c/d® Canine and w/d® Canine Urinary pH of individual dogs may vary due to several complicating factors including time of feeding before urine collection, type of urine collection and skill of urine collector, individual pet variation and test methodology. A Nutritional Aid for Struvite Crystalluria and Urolithiasis: Prescription Diet® c/d® Canine has low levels of struvite building blocks and produces an acidic urine pH. These nutritional characteristics, (features) help to prevent recurrence, (benefit) of struvite crystalluria, (crystal formation in the urine) and urolithiasis. For obese-prone dogs with struvite crystalluria and urolithiasis, w/d® Canine brand dietary food is a low calorie food with similar nutritional characteristics. Target urine pH for both c/d® Canine and w/d® Canine- 6.2- 6.4. Prescription Diet® Canine Treats are an excellent nutritional complement to c/d® Canine and w/d® Canine. Your progress is saved. Slide 16 of 24 Hill’s® Products Available as Nutritional VNA Level II Module 8: Aids in Treating LUTD:Therapeutic Nutrition Lower Urinary Tract Disease ® Hill’s Products Available as Nutritional Aids in Treating LUTD: Prescription Diet® u/d® Canine Urinary pH of individual dogs may vary due to several complicating factors including time of feeding before urine collection, type of urine collection and skill of urine collector, individual pet variation and test methodology. Urolithiasis- Calcium Oxalate, Urate and Cystine. Prescription Diet® u/d® Canine contains very low levels of calcium, protein and nucleic acids, and promotes the formation of an alkaline urine pH. These nutritional characteristics aid in the management of non-struvite uroliths and crystals. Your progress is saved. Slide 17 of 24 Hill’s® Products Available as Nutritional VNA Level II Module 8: Aids in Treating LUTD:Therapeutic Nutrition Lower Urinary Tract Disease ® Hill’s Products Available as Nutritional Aids in Treating LUTD: FELINE For Struvite Stone and Crystal Dissolution: Prescription Diet® s/d® Feline helps eliminate struvite crystals and uroliths from the urinary tract by reducing urinary concentrations of struvite components and allowing maintenance of a more acidic urine pH. After the initial feeding period, (usually two to three months) c/d® Feline or w/d® Feline veterinary exclusive pet food may be used to help avoid recurrence of Feline LUTD, (FLUTD). Prescription Diet® s/d® Feline For Initial Management of Struvite LUTD: Prescription Diet® s/d® Feline helps eliminate struvite crystals and uroliths from the urinary tract by reducing urinary concentrations of struvite components and allowing maintenance of a more acidic urine pH. Your progress is saved. Slide 18 of 24 Hill’s® Products Available as Nutritional VNA Level II Module 8: Aids in Treating LUTD:Therapeutic Nutrition Lower Urinary Tract Disease ® Hill’s Products Available as Nutritional Aids in Treating LUTD: After the initial feeding period, (usually two to three months) c/d® Feline or w/d® Feline veterinary exclusive pet food may be used to help avoid recurrence of Feline LUTD, (FLUTD). If FLUTD should recur when only c/d® Feline or w/d® Feline is being fed, change to s/d® Feline and monitor appropriately. Because of the increased acidifying effect of s/d® Feline, it is not recommended for long-term maintenance of routine cases of FLUTD where c/d® Feline is adequate to avoid recurrence. Urinary pH of individual dogs may vary due to several complicating factors including time of feeding before urine collection, type of urine collection and skill of urine collector, individual pet variation and test methodology. Your progress is saved. Slide 19 of 24 Hill’s® Products Available as Nutritional VNA Level II Module 8: Aids in Treating LUTD:Therapeutic Nutrition Lower Urinary Tract Disease ® Hill’s Products Available as Nutritional Aids in Treating LUTD: Prescription Diet® c/d® Multicare Feline and w/d® Feline Urinary pH of individual cats may vary due to several complicating factors including time of feeding before urine collection, type of urine collection and skill of urine collector, individual pet variation and test methodology. For Struvite Management: c/d® Multicare Feline contains reduced building blocks of struvite and produces a normal acidic urine pH. These nutritional characteristics, (features) help to prevent, (benefit) recurrence of struvite crystalluria and urolithiasis, an important contributor to FLUTD. For obese-prone cats with struvite crystalluria and urolithiasis, w/d® Feline brand dietary food is a low calorie food with similar nutritional characteristics. Target urine pH for both c/d® Feline and w/d® Feline- 6.2-6.4. Your progress is saved. Slide 20 of 24 Urethral Plugs VNA Level II Module 8: Therapeutic Nutrition Lower Urinary Tract Disease Urethral Plugs Restoring urine flow and stabilizing obstructed male cats is paramount. Because struvite is the most common mineral type in urethral plugs, feeding affected cats, (especially younger cats) for prevention of struvite crystals as mentioned above may help prevent recurrences. As always, results of a urinalysis should dictate therapy. Increasing water consumption and treating bacterial urinary tract infections are important aspects of prevention. Review Figure 5. For more information about LUTD, see Chapters 20 and 21 in Small Animal Clinical Nutrition, 4th ed., the Hill’s Key to Clinical Nutrition, and www.HillsVet.com. Your progress is saved. Slide 21 of 24 VNA Level II Module 8: Monitoring patients with LUTD Therapeutic Nutrition Lower Urinary Tract Disease Monitoring patients with LUTD Monitoring is a critical aspect of treatment and prevention. Generally, radiographs should be taken every two to four weeks to monitor dissolution of bladder uroliths. Uroliths should become progressively smaller with successful therapy. Foods used for dissolution of uroliths are commonly fed for one month after no evidence of bladder stones can be seen on a radiograph. Review Figure 14. Other tests are also useful for monitoring dissolution of uroliths. On urinalysis, urine pH should change to reflect the food being fed. Urine crystals, red and white blood cells, bacteria, and other abnormal urine constituents should decrease progressively. Urine should become less concentrated when canned foods are fed, or if the pet owner is successful in encouraging increased water intake. Recall from Level I, Module 1 (Nutrients) that foods with increased amounts of protein produce more waste products for the kidneys to excrete. Nutritional aids for dissolving and preventing recurrences of uroliths often have reduced amounts of protein to increase urine volume and reduced precursors of certain uroliths. As a consequence, pets exclusively eating such foods may have decreased protein breakdown products in their blood and urine. Blood urea nitrogen (BUN) levels may decrease from what is normal for the pet. All of these tests can be used to help determine whether a client is complying with your practice’s feeding recommendations. Ideally, through effective communications, they should be. Foods used for dissolution of uroliths are commonly fed for one month after no evidence of bladder stones can be seen on a radiograph. Your progress is saved. Slide 22 of 24 VNA Level II Module 8: Monitoring patients with LUTD Therapeutic Nutrition Lower Urinary Tract Disease Monitoring patients with LUTD Because uroliths may recur without consistent health care team follow-up, (proper long-term therapy and pet owner adherence to recommendations) periodic diagnostic studies are important. Radiographs and urinalyses may be necessary every one to three months to monitor the effectiveness of prevention. Remember, surgically removing or dissolving uroliths is not the endpoint of treatment. Prevention and monitoring are equally important. Results of diagnostic studies can help determine whether clients are complying with your practice’s communications for prevention of LUTD. Surgically removing or dissolving uroliths is not the endpoint of treatment! Prevention and monitoring are equally important. Your progress is saved. Slide 23 of 24 VNA Level II Module 8: Therapeutic Nutrition Lower Urinary Tract Disease Summary / Are you ready? Summary Pet owners bringing dog and cats into a veterinary practice because of urinary tract problems are relatively common occurrences. Your understanding of lower urinary tract problems and your ability to effectively communicate can help clients appreciate their pet’s situation, reinforcing the veterinarian’s recommendations for diagnosis, therapy and long-term care. Hill’s® has a variety of Prescription Diet® products that are extremely efficacious in helping manage LUTD, assisting you in your efforts in being an advocate for the pet’s best interest! Are you ready? To continue, you will need to complete the quiz for this module. When you are ready, click on the forward arrow below to take you to the quiz. Your progress is saved. Slide 24 of 24 PROPERTIES On passing, 'Finish' button: On failing, 'Finish' button: Allow user to leave quiz: User may view slides after quiz: User may attempt quiz: Close Window Close Window After user has completed quiz At any time Unlimited times
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