CURRICULUM VITAE
University of Pittsburgh
School of Medicine
BIOGRAPHICAL
Name:
Adam C. Straub, Ph.D.
Birth Date:
May 30, 1980
Home Address:
327 Dewey Avenue,
Pittsburgh, PA 15218
Birth Place:
Erie, Pennsylvania
Home Phone:
814-397-9192
Citizenship:
U.S.A.
E-Mail Address:
[email protected]
Business Address: E1254 BST
200 Lothrop Street
Pittsburgh, PA 15261
Business Phone:
(412) 648-7097
Business Fax:
(412) 648-5980
________________________________________________________________________________________
EDUCATION and TRAINING
UNDERGRADUATE:
1999-2003
Allegheny College,
Meadville, PA
B.S., 2003
Biology
University of Pittsburgh
Ph.D., 2008
Cardiovascular
Toxicology
GRADUATE:
2004-2008
POSTGRADUATE:
2008-2013
Postdoctoral Fellow
Postdoctoral Fellow Vascular Biology
University of Virginia
Charlottesville, VA
________________________________________________________________________________________
APPOINTMENTS and POSITIONS
June 1-Nov 31, 2013
Visiting Assistant Professor
Department of Pharmacology and Chemical Biology
University of Pittsburgh School of Medicine
Pittsburgh, PA 15261
June 1 2013 – present
Heart, Lung, Blood and Vascular Medicine Institute Principal
Investigator and Scholar
University of Pittsburgh School of Medicine
Pittsburgh, PA 15261
Dec 1, 2013 - Present
Assistant Professor (Tenure Stream)
Department of Pharmacology and Chemical Biology
University of Pittsburgh School of Medicine
Pittsburgh, PA 15261
________________________________________________________________________________________
MEMBERSHIPS in PROFESSIONAL and SCIENTIFIC SOCIETIES
• Member, American Physiological Society
2009- present
• Member, Microcirculation Society
2009- present
• Member, American Heart Association, ATVB and Hypertension councils 2012- present
• Member, Nitric Oxide Society
2012- present
• Member, North American Vascular Biology Organization
2016- present
• Member, Society of Toxicology
2005- 2008
________________________________________________________________________________________
HONORS
•
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•
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•
•
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Delta Omega National Honor Society Recipient for Schools of Public Health (2014)
Irvine H. Page Young Investigator Award: ATVB-AHA conference (2013)
Microcirculation Travel Award: Oxford, UK (2012)
Robert M. Berne Outstanding Trainee Award: University of Virginia (2011)
Pappenheimer Postdoctoral Award: Microcirculation Society (2010)
Rosenkranz Award for Public Health Significance: University of Pittsburgh (2008)
Deans Day Best Presentation: Graduate School of Public Health-University of Pittsburgh (2008)
Best Overall Poster: Metals Section-National Society of Toxicology Meeting (2008)
National Environmental Public Health Conference Student Travel Award, Atlanta, GA (2006)
Graduate School of Public Health Deans Day Award Recipient - Kletei Prize for Excellence in
Environmental Health (2006)
Graduate Student Poster Award: Best Overall Poster - Allegheny Erie Society of Toxicology Meeting,
Pittsburgh, PA (2006)
PUBLICATIONS
1. Refereed Articles
1. Straub AC, Stolz DB, Ross MA, Hernandez-Zavala A, Soucy NV, Klei LR, Barchowsky A.
Arsenic stimulates sinusoidal endothelial cell capillarization and vessel remodeling in mouse
liver. Hepatology. 45:205-212, 2007.
2. Straub AC, Stolz DB, Vin H, Ross MA, Soucy NV, Klei LR, Barchowsky A. Low level arsenic promotes
progressive inflammatory angiogenesis and liver blood vessel remodeling in mice. Toxicol Appl
Pharmacol. 222:327-336, 2007.
3. Straub AC, Clark KA, Ross MA, Chandra AG, Li S, Gao X, Pagano PJ, Stolz DB, Barchowsky A.
Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH-oxidase generated
superoxide. J Clin Invest. 118:3980-9, 2008.
4. Straub AC, Klei, LR, Stolz DB, Barchowsky A. Arsenic requires sphingosine-1 phosphate type 1
receptors to induce angiogenic genes and endothelial cell remodeling. Am J Path. 174:1949-58, 2009.
5. Johnstone SR, Ross J, Rizzo MJ, Straub AC, Lampe P, Leitinger N, Isakson BE. Differential Cx43
phosphorylation and smooth muscle cell proliferation, in vivo. Am J Path. 175: 916-24, 2009.
6. Straub AC, Johnstone SR, Rizzo MJ, Heberlein KR, Best AK, Boitano S, Isakson BE. Connexin
phosphorylation can regulate heterocellular communication between smooth muscle and endothelium. J
Vasc Res. 47:277-286, 2009.
7. Heberlein K, Straub AC, Best AK, Looft-Wilson RC, Isakson BE. Plasminogen activator inhibitor-1 can
regulate myoendothelial junction formation. Circ Res. 106:1092-1102, 2010.
• Editorial: Segal SS and Bagher P. Regulation of myoendothelial junction formation:
bridging the gap. Circ Res. 106:1014-6, 2010.
8. Koval M, Billaud M, Straub AC, Zarbock A, Duling BR, Isakson BE. Spontaneous lung dysfunction and
fibrosis in mice lacking connexin 40 and endothelial cell connexin43. Am J Path. 178(6):2536-46, 2011.
9.
Billaud M, Lohman AW, Straub AC, Looft-Wilson R, Johnstone SR, Araj CA, Best AK, Chekeni F,
Ravichandran K, Penuela S, Laird D, Isakson BE. Pannexin1 regulates α1-adrenergic receptormediated vasoconstriction. Circ Res. 109:80-85, 2011.
• Cover Art
• Commentary: Pannexin1 in the regulation of vasoconstriction. Circ Res. 109:1, 2011
10. Straub AC, Billaud M, Johnstone SR, Best AK, Yemen S, Dwyer ST, Looft-Wilson R, Lysiak JJ, Gaston
B, Palmer LA, Isakson, BE. Compartmentalized connexin 43 S-nitrosylation/denitrosylation regulates
heterocellular communication in the vessel wall. Arterioscler Thomb Vasc Biol. 31(2):399-407, 2011.
• Cover Art
11. Billaud M, Lohman AW, Straub AC, Johnstone SR, Isakson, BE. Characterization of the thoracodorsal
artery: morphology and reactivity. Microcirculation. 19(4):360-72, 2012.
12. Heberlein KR, Han J, Straub AC, Best AK, Wojta J, Isakson BE. Identification of a novel RNA binding
protein complex to promote localized increases in plasminogen activator inhibitor-1 at the
myoendothelial junction. Arterioscler Thomb Vasc Biol. 32(5):1271-9, 2012.
13. Lohman AW, Billaud M, Straub AC, Johnstone SR, Best AK, Lee MY, Barr K, Penuela S, Laird DW,
Isakson BE. Expression of pannexin isoforms in the systemic murine arterial network. J Vasc Res.
2012;49(5):405-16, 2012.
14. Johnstone SR, Kronke B, Straub AC, Best AK, Dunn CA, Mitchelle LA, Peskova Y, Nakomoto RK,
Koval M, Lampe PD, Columbus L, Isakson BE. Connexin 43 phosphorylation controls cell proliferation.
: Circ Res. 6;111(2):201-11, 2012.
15. Lohman AW, Weaver JL, Billaud M, Sandilos JK, Griffiths R, Straub AC, Penuela S, Leitinger N, Laird
DW, Bayliss DA, Isakson BE. S-nitrosylation inhibits pannexin 1 channel function. J Biol Chem.
16;287(47):39602-12, 2012.
16. Straub AC, Lohman AW, Billaud M, Johnstone SR, Lee MY, Schoppee-Bortz P, Best AK, Dwyer ST,
Columbus L, Gaston B, Isakson BE. Endothelial cell expression of hemoglobin α regulates nitric oxide
signaling. Nature. 15;491(7424):473-7, 2012.
• News and Views Commentary: Vascular Biology: Nitric oxide caught in traffic
Gladwin MT and Kim-Shapiro DB. Nature. 491, 344-345, 2012
• Editor’s Choice: Vascular Biology: A value for nitric oxide
Andrianantoandro E. Sci. Signal. 5(251), 297, 2012.
• Commentary: General Physiology: Reducing NO signalling to smooth muscle
Alder EM. J. General Physiology. 141(1):1, 2012
• Faculty of 1000 recommendation
17. Billaud M, Straub AC. Haemoglobin alpha regulates nitric oxide in endothelial cells. Med Sci.
5;29(5):471-3, 2013.
18. Cechova S, Zeng Q, Billaud M, Rudy CK, Straub AC, Chi L, Chan FR, Hu J, Griffiths R, Howell NL,
Madsen K, Jensen B, Palmer LA, Carey R, Sung SS, Malakauskas SM, Isakson BE, Le TH. Loss of
collectrin, an ACE2 homologue, uncouples endothelial nitric oxide synthase and causes hypertension
and vascular dysfunction. Circulation, 15;128(16):1770-80, 2013
19. Straub, A.C., Butchner JT, Billaud M, Mutchler SM, Artamonov MV, Nguyen AT, Johnson T, Best, AK,
Miller MP, Palmer LA, Columbus L, Somlyo AV, Le, TH, Isakson BE. Hemoglobin α/ eNOS coupling at
myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction. Arterioscler
Thromb Vasc Biol 34:2594-2600, 2014
• Editors Pick
20. Kavoussi PK, Heberlein K, Straub AC, Lowe GJ, Oliver JL, Smith RP, Steers WD, Annex BH, Isakson
BE, Lysiak JJ. Recombinant PAI-1 therapy restores myoendothelial junctions and erectile function in
PAI-1-deficient mice. Andrologia. 2015 47(10):1147-52.
21. Shankman LS, Gomez D, Cherepanova OA, Salmon M, Alenca GF, Haskins RM, Swiatlowska P,
Newman AC, Greene ES, Straub AC, Isakson BE, Randolph GJ, Owens GK. KLF4 Dependent
Phenotypic Modulation of SMCs Play a Key Role in Atherosclerotic Plaque Pathogenesis. Nature
Medicine 2015: 21(6): 628-37
22. Rahaman MM, Reinders FG, Koes D, Nguyen AT, Mutchler SM, Sparacino-Watkins C, Alvarez RA,
Miller MP, Cheng D, Chen BB, Jackson EK, Camacho CJ, Straub AC. Structure Guided Chemical
Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome b5 Reductase 3
that Increase Nitric Oxide Bioavalibility. J Biol Chem. 2015 3;290(27):16861-72.
23. Zaman K, Sawczak V, Zaidi A, Butler M, Bennett D, Getsy P, Zeinomar M, Greenberg Z, Forbes M,
Rehman S, Jyothikumar V, DeRonde K, Sattar A, Smith L, Corey D, Straub A, Sun F, Palmer LA,
Periasamy A, Randell S, Kelley T, Lewis S, and Gaston B. Augmentation of CFTR maturation by Snitrosoglutathione reductase. AJP Lung Cellular and Molecular Physiology 2016 1;310(3):L263-70
24. Ivanov S, Scallan JP, Kim KW, Werth K, Johnson MW, Saunders BT, Wang PL, Kuan EL, Straub AC,
Ouhachi M, Weinstein EG, Williams JW, Briseño C, Colonna M, Isakson BE, Gautier EL, Förster R,
Davis MJ, Zinselmeyer BH, Randolph GJ. CCR7 and IRF-4-dependent dendritic cells regulate
lympathic collecting vessel permeability. J Clin Invest 2016 1;126(4):1581-91.
25. Biwer LA, Taddeo EP, Kenwood BM, Hoehn KL, Straub AC, Isakson BE. Two functionally distict pools
of eNOS in endothelium are facilitated by myoendothelial junction lipid composition. Biochim Biophys
Acta 2016 7;1861(7):671-9
26. Rogers NM, Sharifi-Sanjani M, Yao M, Ghimire K, Bienes-Martinez R, Mutchler SM, Knupp HE, Baust J,
Novelli EM, Ross M, St Croix C, Kutten JC, Czajka CA, Sembrat JC, Rojas M, Labrousse-Arias D,
Bachman TN, Vanderpool RR, Zuckerbraun BS, Champion HC, Mora AL, Straub AC, Bilonick RA,
Calzada MJ, Isenberg JS. TSP1-CD47 Signaling is Upregualted in Clincial Pulmonary Hypertension
and Contributes to Pulmonary Arterial Vasculopathy and Dysfunction. Cardiovasc Res. 2016 Oct 13. In
press.
2. Reviews, invited published papers, proceedings of conferences, books and book chapters
1. Heberlein K., Straub AC, Isakson BE. The myoendothelial junction: breaking through the
matrix? Microcirculation. 28:1-16, 2009.
2. Billaud M, Johnstone SR, Heberlein KR, Straub AC, Isakson BE. The effect of oxidative stress on
connexins/pannexins in the vasculature. Book Chapter: Connexin cell communication channels roles on
the immune system and immunopathology: Published by Taylor and Francis, New York, 2011. Editors:
Oviedo-Orta E, Kwak BR and Evans WH.
3. Looft-Wilson R, Billaud M, Johnstone SJ, Straub AC, Isakson BE. Interaction between Nitric Oxide
Signaling and Gap Junctions: Effects on Vascular Function. Biochim Biophys Acta. 8;1818(8):1895-902,
2012.
4. Straub AC, Zeigler AC, Isakson BE. The myoendothelial junction: connections that deliver the message
(Review). Physiology. In Press 2013.
5. Rahaman MM and Straub AC. The emerging roles of somatic globins in cardiovascular redox biology
and beyond (Review). Redox Biology. 8:16;1(1):405-410. 2013
6. Mutchler SM, Straub AC. Compartmentalized nitric oxide signaling in the resistance vasculature. Nitric
oxide 2015 May 28;49:8-15
7. Lohman AW, Straub AC, Johnstone SR Identification of Connexin 43 Phosphorylation and SNitrosylation in Cultured Primary Vascular Cells. Methods Mol Biol. 2016;1437:97-111.
________________________________________________________________________________________
PROFESSIONAL ACTIVITIES
TEACHING:
Mentored Post-Doctoral and Clinical Fellows:
1. Supervisor/ Mentor to Dr. Mizanur Rahaman, Postdoctoral Associate, Vascular Medicine Institute,
meeting approximately 6-8 h per week, Oct 2013 - June 2015.
• 1st authored publication in Redox Biology and Journal of Biological Chemistry
• American Heart Association Post-doctoral Fellowship
• Invited speaker to the 2014 Nitrite/Nitrate Conference in Cleveland, OH
• Currently an Assistant Professor in Dhaka University
2. Supervisor/ Mentor to Dr. Anh Nguyen, Postdoctoral Fellow, Vascular Medicine Institute, meeting
approximately 6-8 h per week, Nov 2013-June 2015.
• Co-first author publication in review
•
•
•
•
•
T32 recipient from Renal Division (PI: Kleyman)
Invited speaker to the University of Pittsburgh School of Medicine Research Day. Selected from
134 applicants to present her research.
3rd place poster award at the 2015 Pittsburgh American Heart Association Conference
Poster Prize winner at the 2015 Nitric Oxide Gordon Research Conference, Ventura CA
Currently a Research Scientist at the University of Virginia
3. Supervisor/ Mentor to Dr. Roger Alvarez, Pulmonary Fellow, Vascular Medicine Institute, meeting
approximately 6-8 h per week, Oct 2014-present.
• Received a Breath PA research grant
• ATS minority travel award
• Currently an Assistant Professor of Medicine at the University of Miami
4. Supervisor/ Mentor to Dr. Katherine Wood, Postdoctoral Fellow, Vascular Medicine Institute, meeting
approximately 6-8 h per week, July1-present
5. Coordinator/Mentor, Vascular Medicine Institute Postdoctoral Journal Club, University of Pittsburgh,
2013-2015. Number of fellows: ~15-20. Preparation and time at seminar: 1 h per week.
Teaching of Medical School Students:
1. Small group leader, Cell Signaling/Pharmacology Workshop classroom teaching for 6 medical
students, University of Pittsburgh School of Medicine, Pittsburgh, PA, total contact hours=2, 2013.
2. Small group leader, Adrenergic Pharmacology Workshop classroom teaching for 6 medical students,
University of Pittsburgh School of Medicine, Pittsburgh, PA, total contact hours=2, 2013.
3. Small group leader, Adrenergic Pharmacology Workshop classroom teaching for 6 medical students,
University of Pittsburgh School of Medicine, Pittsburgh, PA, total contact hours=2, 2014.
4. Small group leader, Pharmacokinetics Pharmacology Workshop classroom teaching for 6 medical
students, University of Pittsburgh School of Medicine, Pittsburgh, PA, total contact hours=2, 2014.
5. Small group leader, Pharmacokinetics Workshop classroom teaching for 6 medical students,
University of Pittsburgh School of Medicine, Pittsburgh, PA, total contact hours=2, 2015.
6. Small group leader, Adrenergic Workshop classroom teaching for 6 medical students, University of
Pittsburgh School of Medicine, Pittsburgh, PA, total contact hours=2, 2015.
7. Small group leader, GPCR Workshop classroom teaching for 6 medical students, University of
Pittsburgh School of Medicine, Pittsburgh, PA, total contact hours=2, 2015.
8. Lecturer/group leader, Intensive Laboratory Research Experience in the classroom and at the bench
for 25 first year Pitt Medical Students. Mount Desert Island Biological Laboratory, Salisbury Cove,
Maine, total contact hours=123, 2014.
9. Lecturer/group leader, Intensive Laboratory Research Experience in the classroom and at the bench
for 25 first year Pitt Medical Students. Mount Desert Island Biological Laboratory, Salisbury Cove,
Maine, total contact hours=123, 2015.
10. Small group leader, Pharmacokinetics Workshop classroom teaching for 6 medical students,
University of Pittsburgh School of Medicine, Pittsburgh, PA, total contact hours=2, 2016.
11. Small group leader, Adrenergic Workshop classroom teaching for 6 medical students, University of
Pittsburgh School of Medicine, Pittsburgh, PA, total contact hours=2, 2016.
12. Small group leader, GPCR Workshop classroom teaching for 6 medical students, University of
Pittsburgh School of Medicine, Pittsburgh, PA, total contact hours=2, 2016.
Mentored Graduate Students:
1. Supervisor/ Mentor to Stephanie Mutchler, Pre-doctoral trainee, Department of Pharmacology and
Chemical Biology, meeting approximately 6-8 h per week, June, 1 2014 - 2015.
• T32 Recipient for Angiopathy Training Grant
• Benjamin W. Zweifach Student Award from the Microcirculation Society (2015)
• Currently a graduate student with Dr. Tom Kleyman at the University of Pittsburgh
Rotation Graduate Students: Stephanie Mutchler, Anna Roessing (IBGP), Helene Altmann (MD/PHD),
Joseph Galley (IBGP)
Teaching of Graduate Students:
1. Lecturer, Department of Environmental and Occupational Health, Graduate School of Public Health,
Pathophysiology of Environmental Disease Course 3210, Cells and Tissues of the Cardiovascular
System: Blood Vessels March 2015
2. Lecturer, Department of Environmental and Occupational Health, Graduate School of Public Health,
Pathophysiology of Environmental Disease Course 3210, Cells and Tissues of the Cardiovascular
System; Heart March 2015
3. Lecturer, University of Pittsburgh School of Medicine Graduate Students. Grant writing course. Fall
2016
Service on Masters or PhD Thesis and Comprehensive Exam Committees:
1. Janelle Bickta, "Characterization of Oxygen-Independent Functions of Myoglobin" University of
Pittsburgh Swanson School of Engineering. March 18, 2015.
2. Soma Jobbagy, "NO 2 -OA and Kidney Disease" University of Pittsburgh, Molecular Pharmacology
Training Program June 26th, 2015.
Mentored Undergraduate Students:
1. Research supervisor to Quanqian Zhang, Visiting Medical student from Tsinghua University,
University of Pittsburgh, Sept 2013. Currently medical student at Tsinghua University.
2. Research supervisor to Amogha Vijayvargiya, University of Pittsburgh, June 2014-present.
3. Research supervisor to Nolan Carew, University of Pittsburgh, May 2016-present. American Heart
summer undergraduate recipient through the University of Pittsburgh
4. Research supervisor to Rohan Shah, University of Pittsburgh, August 2016-present.
5. Research supervisor to Yifei Wang, Visiting Medical student from Tsinghua University, University of
Pittsburgh, Sept 2016.
Teaching of Undergraduate Students:
1. Lecturer, American Heart Association Undergraduate Summer Research Program at the Vascular
Medicine Institute. Microcirculation and Endothelial Cell Function. June 2015
RESEARCH:
1. Current Grant Support:
Grant Number
Role in
Project /
% Effort
Grant Title
Years
Inclusive
Source
Amount
R01 HL128304
Vascular smooth muscle and blood
pressure regulation by Cyb5R3
PI -6 CM
07/01/2016- $1,983,500
06/30/2021
R01 HL133864-01
Novel role of smooth muscle B5 reductase PI- 3 CM
in Sickle Cell disease
08/01/2016- $2,417,236
07/30/2020
Bayer Pharma
Contract
Cyb5R3 and cGMP signaling
PI 2.4CM
01/201701/2019
$387,135
(Hemophilia Ctr of
Western PA)
Hemostasis and Vascular Biology
Research Institute –Straub/Gladwin
PI- 2.52 CM
07/01/1206/30/18
$130,00
University of
Pittsburgh Kidney
Center
Role of Cyb5R3 in Renal Endothelial Cell
Function
PI- 0.12 CM
08/01/1507/31/17
$60,000
R01 HL 125777
Microbubble-Mediated Ultrasonic Therapy
for Coronary Microvascular Obstruction
Co-I 0.36 CM
07/01/1506/30/17
$12,644
Years
Inclusive
10/01-2015
-09/31/2020
Source
Amount
$$2,417,23
6
03/201702/2021
04/01/201703/31/2022
04/01/201703/31/2022
$10,205
Years
Inclusive
01/01/1612/31/18
Source
Amount
$154,000
Pending Grant Support
Grant Number
Role in
Project /
Grant Title
R01 HL13016201
(to be resubmitted in Oct.
2017)
NIH R01 PI Devor
Cyb5R3 and atherosclerosis
PI
2.4 CM
Sk1 and endothelial function
Co-I 0.6CM
NIH R01
PI-Halder
NIH R01
PI-Olafiranye
Genomic Characterization of Heart Failure
in African Americans
Biochemical and Reno-Protective Effects
of Remote Ischemic Preconditioning on
Contrast-Induced Acute Kidney Injury
Co-I 0.6CM
Co-I 0.6CM
$10,205
$10,205
Prior Grant Support:
Grant Number
AHA Grant-in-Aid
25090129
*Declined in July
2016 due to
overlap with R01
HL128304
Role in
Project /
Grant Title
Cyb5R3 and Vascular Function
PI
R00 HL11290402
(NIH/NHLBI)
University of
Pittsburgh,
VMI/HVI
Innovator Award
University of
Pittsburgh,
VMI/HVI
Innovator Award
University of
Pittsburgh,
Alzheimer’s
Disease
Research Center
Pilot Award
K99 HL112904
(NIH/NHLBI)
F32 HL103042
(NIH/NHLBI)
T32 HL7284
(NIH/NHLBI)
FP-91654201
EPA
Mechanisms of intracellular NAMPTregulated GSNOR in the vessel wall
PI
9 cal
08/01/1307/30/16
$747,000
The role of hemopressin in reversing
essential hypertension
Co-PI
0
07/01/1406/30/15
$25,000
Atrial Fibrillation from an Endothelial
Perspective
Co-PI
0
12/01/1411/30/15
$25,000
Cyb5R3 and Alzheimer’s Disease
PI
03/01/1502/28/16
$25,000
Mechanisms of intracellular NAMPTregulated GSNOR in the vessel wall
Mechanisms of NAMPT-stimulated nitric
oxide release at the myoendothelial
junction
Mechanisms of nitric oxide signaling at the
myoendothelial junction
Mechanisms of arsenic-induced liver
sinusoidal endothelial cell remodeling
PI
05/01/1204/30/13
09/01/1008/31/11
$90,000
09/01/0808/31/10
08/01/0507/31/08
$78,000
PI
Trainee
PI
$52,000
$112,500
2. Seminars and invited lectureships
April 2017
University of Texas A&M, College Station, Texas, Cyb5R3 and cardiovascular
function
March 2017
University of Virginia School of Medicine, Charlottesville, VA, Unraveling new roles for
Cyb5R3 in the cardiovascular system
March 2017
Centro Andaluz de Biología del Desarrollo, Seville, Spain, New insights into
cardiovascular regulation by Cyb5R3
February 2017
Nitric oxide Gordon Conference, Ventura, California, Cyb5R3 and cGMP siganaling
June 2016
Hematology and Oncology Seminar Series, University of Pittsburgh. Nitric oxide,
hemoglobin, and methemoglobin reductase: new insights into cardiovascular
regulation"
May 2016
National Institute on Aging, Baltimore MD. "New Insights into cardiovascular regulation
by Cyb5R3"
May 2016
Renal Division Seminar Series, University of Pittsburgh. Nitric oxide, hemoglobin, and
methemoglobin reductase: new insights into blood pressure regulation.
April 2016
Heart, Lung Blood and Vascular Medicine Institute, University of Pittsburgh. Hemeindependent regulation of cardiovascular function by alpha globin
Oct 2015
Science 2015, University of Pittsburgh. "I'm positive I lost an electron: Transferring
Signaling Mechanisms from Red Cells to Vascular Cells
Sept 2015
American Heart Association, Council on Hypertension. "Cytochrome B5 Reductase 3
sensitizes soluble guanylate cyclase to nitric oxide".
Sept 2015
Metals in Biology Symposia, Duquesne University. "Mechanisms of Heme Iron Redox
Regulation in Vascular Cells".
Oct 2014
Department of Environmental and Occupational Health, Graduate School of Public
Health, University of Pittsburgh. "Vascular smooth muscle and blood pressure
regulation by Cyb5R3"
May 2014
Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh "Putting the
brakes on nitric oxide signaling: the emerging biology of hemoglobin and methemoglobin
reductase in vascular cells".
April 2014
West Virginia University, Morgantown, WV "Putting the brakes on nitric oxide signaling:
the emerging biology of hemoglobin and methemoglobin reductase in vascular cells".
July 2013
National Institutes of Health, NHLBI K-award meeting – Bethesda, MD
“Critical residues of the hemoglobin α / eNOS complex regulation nitric oxide signaling.”
May 2013
Nitrite and Nitrate in Physiology, Pathophysiology, and Therapeutics– Pittsburgh, PA
“Hemoglobin α / eNOS complex regulates nitric oxide signaling.”
May 2013
American Heart Association ATVB conference – Orlando, FL
“Critical residues of the hemoglobin α / eNOS complex regulation nitric oxide signaling.”
February 2013
Gordon Research Conference on Nitric Oxide – Ventura, CA
“Mechanisms of nitric oxide regulation by hemoglobin alpha in the endothelium”
December 2012
Department of Pharmacology and Chemical Biology – University of Pittsburgh
Pittsburgh, PA
“Nitric oxide control by endothelial cell hemoglobin α regulates arterial vascular
reactivity”
November 2012
Robert M. Berne Cardiovascular Research Center 20th anniversary symposia –
University of Virginia, Charlottesville, VA
“Mechanisms of nitric oxide regulation by hemoglobin alpha in the endothelium”
October 2012
Department of Pulmonary, Allergy and Critical Care Medicine – Case Western University
Cleveland, OH
“Mechanisms of nitric oxide regulation by hemoglobin alpha in the endothelium”
August 2012
Vascular Medicine Institute – University of Pittsburgh, Pittsburgh, PA
“Nitric oxide control by endothelial cell hemoglobin α regulates arterial vascular
reactivity”
July 2012
International Conference of NO in Biology and Physiology Conference – Edinburgh, UK
“Endothelial cell expression of hemoglobin α regulates nitric oxide signaling”
July 2012
International Conference on Microcirculation – Oxford, UK
“Hemoglobin α expression in endothelial cells regulates nitric oxide signaling”
June 2012
Department of Pathology and Center for Free Radical Biology – University of Alabama
Birmingham, Birmingham, AL
“Endothelial cell expression of hemoglobin α regulates nitric oxide diffusion”
June 2011
Vascular Medicine Institute – University of Pittsburgh, Pittsburgh, PA
“Mechanisms of nitric oxide control of gap junction communication in the vessel wall”
June 2011
Robert M. Berne Cardiovascular Research Center – University of Virginia,
Charlottesville, VA
“Compartmentalized nitric oxide signaling at the myoendothelial junction regulates
heterocellular communication in the vessel wall”
April 2011
Experimental Biology, Redox signaling in vascular biology – San Diego, CA
“Compartmentalized redox signaling at the myoendothelial junction regulates
heterocellular communication in the vessel wall.”
3. Other research related activities
Chaired sessions at national/international meetings:
September 2016
Co-Moderator at the AHA Council on High Blood Pressure Conference " Vascular
and Neurogenic Mechanisms in Obesity"
June 2014
Session Chairman at the International Nitrite/Nitrate Conference "Mechanisms
regulating NO pathways" Cleveland, OH
December 2013
Chairman of the 9th annual mini-symposium on Metals in Biological Systems –
Duquesne University, Pittsburgh, PA
April 2012
Chairman of the Microcirculation Society Young Investigators SymposiaExperimental Biology, San Diego, CA
Editorial Board
1. Microcirculation
Journal Reviewer (Ad Hoc):
• American Journal of Physiology Lung and Cellular and Molecular Physiology
• British Journal of Pharmacology
• Cell Calcium
• Hypertension
• Microcirculation
• PLOS ONE
• Free Radical Biology and Medicine
• American Journal of Pathology
• Journal of Pharmacology and Experimental Therapeutics
• Antioxidant and Redox Signaling
• Vascular Medicine
• JoVE
• Journal of the American Heart Association
• Microvascular Research
Grant Reviewer:
• American Heart Association; Member of Vascular Wall Biology 2 Committee, 2013
• American Heart Association; Member of Vascular Wall Biology, Blood Pressure, 2014-present
• Medical Research Council, UK Ad Hoc 2015
LIST OF CURRENT RESEARCH INTERESTS
• Nitric oxide
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Hemoglobin
Cytochrome b5
Cytochrome B5 Reductase,
Hemopressin
Microcirculation
Reactive oxygen and nitrogen signaling
Systemic Hypertension
Blood flow regulation
Hemolysis
SERVICE:
Intramural
• Grant reviewer for PACCM/VMI/Cardiology for NRSA, Ks, and first R’s.
• Grant reviewer for Cardiology Innovator Awards
• Panel member for K award workshop, University of Pittsburgh
• Pittsburgh AHA Steering Committee Member for the Undergraduate Research Program
• Chaired and organized the 2015 Department of Pharmacology and Chemical Biology Retreat
• Grant Reviewer for VMI-Cardiology Innovator grants
• Organizing Committee for the 2017 University of Pittsburgh Hypertension Retreat
Extramural
• American Heart Association, Arteriosclerosis, Thrombosis and Vascular Biology Early Career
Committee Member (2016-present)
• Pittsburgh AHA Research Day Judge (2016-2017)
• Scientific reviewer of the MRC Clinical Sciences Centre at Imperial College in London (Nitric oxide
signaling)
Intellectual Property
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Targeting Cyb5R3: University of Pittsburgh, PCT/US2015/049689
Compositions and Methods of Regulating Arterial Tone: University of Virginia, U. S. Patent Application
Serial No. 14,437,548