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Pathway
Reaction equation
Lipid metabolism; C21-steroid hormone metabolism
Cholesterol->Pregnenolone
Lipid metabolism; steroid biosynthesis
Pregnenolone->17-alpha hydroxy pregnenolone
Lipid metabolism; steroid biosynthesis
Pregnenolone->Progesterone
Lipid metabolism; steroid biosynthesis
Progesterone->17-hydroxy progesterone
Lipid metabolism; steroid biosynthesis
17-alpha hydroxy pregnenolone->17-hydroxy progesterone
Steroidogenesis
17-hydroxy progesterone->11-deoxycortisol
Lipid metabolism,Steroid metabolism,Steroidogenesis
11-deoxycortisol->Cortisol
Lipid metabolism; steroid biosynthesis
17-alpha hydroxy pregnenolone->Dehydroepiandrosterone
prostaglandin metabolic process
Dehydroepiandrosterone->Androstenediol
Lipid metabolism; steroid biosynthesis
Androstenediol->Testosterone
Differentiation,Sexual differentiation
Testosterone->Dihydrotestosterone
estrogen biosynthetic process,xenobiotic metabolic process
Testosterone->Estradiol
Lipid metabolism; steroid biosynthesis
Dehydroepiandrosterone->Androstenedione
Lipid metabolism;steroid biosynthesis
17-hydroxyprogesterone->Androstenedione
prostaglandin metabolic process
Androstenedione->Testosterone
estrogen biosynthetic process,xenobiotic metabolic process
Androstenedione->Estrone
prostaglandin metabolic process
Estrone<->Estradiol
EC
1.14.15.6
1.14.99.9
1.1.1.145,5.3.3.1(constitutes 2 domains)
1.14.99.9
1.1.1.145,5.3.3.1(constitutes 2 domains)
1.14.99.10
1.14.15.4
1.14.99.9
1.1.1.64
1.1.1.145,5.3.3.1(constitutes 2 domains)
1.3.99.5
1.1.1.64
1.1.1.145,5.3.3.1(constitutes 2 domains)
1.14.99.9
1.1.1.64
1.14.14.1
1.1.1.64
Protein
Name
Protein
ID
P05108
P05093
P26439
P05093
P26439
P08686
P15538
P05093
P42330
P26439
P31213
P42330
P26439
P05093
P42330
P11511
P42330
Subcellular Location
Mitochondrion membrane.
Membrane
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Membrane
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Mitochondrion membrane.
Membrane
Cytoplasm
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein
Cytoplasm
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Membrane
Cytoplasm
Membrane; Peripheral membrane protein.
Cytoplasm
Organism
Cell type
Homo sapiens
Homo sapiens
Homo sapiens
Homo sapiens
Homo sapiens
Homo sapiens
Homo sapiens
Homo sapiens
Homo sapiens
Homo sapiens
Homo sapiens
Homo sapiens
Homo sapiens
Homo sapiens
Homo sapiens
Homo sapiens
Homo sapiens
Reference1
(reaction exists)
PMID: 12573809
PMID: 22138857
PMID: 22024430
PMID: 18068870
PMID: 22024430
PMID: 22001566
PMID: 15026188
PMID: 18068870
PMID: 20659585
PMID: 18067894
PMID: 18067894
PMID: 10731101
PMID: 11339818
PMID: 22138857
PMID: 21185375
PMID: 15784278
PMID: 15784278
Reference3
(enzyme
Reference2 (enzyme catalyzes this reaction)
subcellular
Cholesterol desmolase
Steroid 17-alpha-hydroxylase/17,20 lyase
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
Steroid 17-alpha-hydroxylase/17,20 lyase
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
Steroid 21-hydroxylase
Steroid 11-beta-hydroxylase
Steroid 17-alpha-hydroxylase/17,20 lyase
Aldo-keto reductase family 1 member C3
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Cytochrome P450 19A1
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
Steroid 17-alpha-hydroxylase/17,20 lyase
Aldo-keto reductase family 1 member C3
Cytochrome P450 19A1
Aldo-keto reductase family 1 member C3
complex name Protein Name
Cholesterol desmolase
Steroid 17-alpha-hydroxylase/17,20 lyase
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
Steroid 21-hydroxylase
Steroid 11-beta-hydroxylase
Steroid 17-alpha-hydroxylase/17,20 lyase
Aldo-keto reductase family 1 member C3
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Cytochrome P450 19A1
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
Steroid 17-alpha-hydroxylase/17,20 lyase
Aldo-keto reductase family 1 member C3
Cytochrome P450 19A1
Aldo-keto reductase family 1 member C3
Type UniProt ID Synonyms Comment
P05108
P05093
P26439
P26439
P08686
P15538
P05093
P42330
P26439
P31213
P42330
P26439
P05093
P42330
P11511
P42330
Compound Name
KEGG CID
Cholesterol
Pregnenolone
Progesterone
17-alpha hydroxy pregnenolone
17-hydroxy progesterone
11-deoxycortisol
Cortisol
Dehydroepiandrosterone
Androstenediol
Testosterone
Dihydrotestosterone
Estradiol
Androstenedione
Estrone
ChEBI
Comments
17002
16581
17026
16581 Showed up the same results as for pregnenolone
17026
28324
23396
28689
Did not show up any results in ChEBI
17347
GO:0035410
GO:0047882
GO:0035941
17263