Excellence IN Aging Care Symposium
September 25, 2014
The work of these industrious insects . . .
and the floral splendor of creation . . .
Violet
Jasmine
Golden Poppy
Lily
Goldenrod
Amaryllis
Honey is a non-standardized product
 Many small, observational studies
 Few randomized, controlled population
studies

Alternative Medicine
 Outside the Mainstream of Clinical
Practice
 Preventative versus Therapeutic

1. HONEY regulates blood sugar and insulin
levels
2. HONEY is the Gold Standard brain fuel
3. HONEY prevents or eliminates metabolic
stress
4. HONEY promotes recovery sleep and fuels
the brain during the night
5. HONEY enhances immune system
function and provides other miscellaneous
benefits
1
HONEY regulates blood
sugar and insulin levels
The sugars in HONEY end up in the
liver rather than in the blood
 HONEY contains substances needed to
make a protein in the liver that regulates
insulin release from the pancreas (HISS)

Diabetic Medicine 2:371, 1985
J Med Food. 10:473, 2007
Molecules 2012, 17:248-266 – Literature Review
Mean Plasma Levels – Type 1 Diabetics
Diabetic Medicine 2:371, 1985
HONEY is therapeutic for . . .
folks with glucose intolerance, insulin
resistance, diabetes, and reactive
hypoglycemia.
2
HONEY is the Gold Standard
Fuel for the Brain
The primary source of energy for the
brain is GLUCOSE that the brain gets
from
 The circulating blood (total blood
glucose at any one time is only 5
grams)
 The liver glycogen reserve (total of
75 grams)
At rest, 10 grams of glucose are needed
each hour to provide energy for the
 Brain – 6 ½ grams
 The kidneys & red blood cells – 3 ½
grams
***
A full liver glycogen tank provides the
brain with only enough fuel for
7 ½ to 8 hours
HONEY produces more liver glycogen than
any other food, gram-for-gram
 HONEY contains the perfect ratio of fructose
to glucose – nearly 1:1 – necessary to produce
and store glucose in the liver
 One tablespoon of HONEY will result in the
formation of ~ 17 grams of liver glycogen



Without it, the brain, kidneys and red blood
cells would run out of fuel in ~ 30 minutes or
less during moderate activity
The release of glucose from the liver fuels the
brain and prevents or eliminates metabolic
stress
1 Tbsp of HONEY =
Calculations of Liver Glycogen Yield (LGY) taken from Feed Your Brain First (TGBTGBooks.com, LLC 2013)
1 Tbsp of HONEY =
6 Tbsp of Peanut Butter
1 Tbsp of HONEY =
1/4 cup of Raisins or Dates
1 Tbsp of HONEY =
~ 6 oz of Chicken
1 Tbsp of HONEY =
3-4 oz Halibut, Pork
chop or Hamburger
1 Tbsp of HONEY =
3 cups of Mashed Potatoes
1 Tbsp of HONEY =
4 cups of Carrots
2 Eggs = 20 grams
2 Strips Bacon = 4 grams
Coffee with Cream = 2 grams
TOTAL LGY = 75 grams
1 cup OJ = 18 grams
Honey Wheat Toast & Honey = 19 grams
1 cup Fruit = 12-15 grams
TOTAL LGY = 6 grams
Donut or pastry = 4 grams
Coffee with Cream = 2 grams
3
HONEY prevents or eliminates
METABOLIC STRESS
METABOLIC STRESS
Is the release of cortisol and adrenalin
from the adrenal glands
 Is initiated by the brain when it senses its
fuel supply is depleted
 Is necessary to make new fuel for the brain
(neuro-protective)

[Sometimes referred to as the “Fight or Flight”
response]
METABOLIC STRESS

Is easily prevented when you keep fuel in
the tank* and avoid or eliminate brain
hunger
* The brain’s fuel tank is the liver which stores glucose as
glycogen
METABOLIC STRESS
 Is
also initiated by over-consumption
of glucose-rich foods
Rapid rise in blood glucose
 Release of excessive levels of insulin
which drive glucose into the cells
 Increased triglyceride formation
 Little or no liver glycogen formation
 Repeated / chronic brain starvation
 Increased and recurrent metabolic stress


By avoiding over-consumption of glucose rich foods:
Potatoes
Breads
Soda
Pasta
Beverages
Fat Free Foods
Cereal

About 3 pounds (1360 grams) of additional
sugar and HFCS – more than 6 times the
amount recommended by the AHA

55-73 grams of fructose – more than the
liver can metabolize and store at any one
time

Chronic oxidative stress within the cells of
the body, especially the brain cells
Lower blood sugar (blood glucose)
 Less insulin released from pancreas
 Less formation of triglycerides (fats)
 More glucose stored in the liver as glycogen
 Brain’s fuel supply is preserved


Decreasing or eliminating the repeated
excessive release of cortisol and adrenalin
from the adrenal glands initiated by brain
hunger
Reduced Risk for Obesity & Diabetes
 Better Weight Control by regulation of
appetite hormones

1.
2.
3.
Sinha, MK, et al, “Nocturnal Rise of Leptin in Lean, Obese, and Non-insulin-dependent Diabetes Mellitus Subjects,” J Clin
Invest 97(5): 1344-1347 (1996)
Turek, VF, et al, “Mechanisms of Amylin/Leptin Synergy . . .” Endocrinology Vol 151, No 1: 143-152 (2010)
Isidori, AM, et al, “Leptin and Aging: Correlation with Endocrine Changes . . .” The Journal of Clinical Endocrinology &
Metabolism Vol 85, No 5; 1954-1962 9(2000)
Reduced Risk of Thyroid Disease
(Hypothyroidism)
 Reduced Risks for Osteoporosis,
Menopausal Conditions, Infertility and
Gastro-intestinal Diseases

1.
2.
3.
4.
Roos, A, et al, “ Thyroid Function is Associated with Components of the Metabolic Syndrome . . .” J Clin Endocrinol
Metab 2007 Feb; 92(2): 491-6
Demidova, OR, “The Role of Thyroid Hypofunction in Development of Metabolic Syndrome,” Ter Arkh 2009; 81(4) 69-73
Brown, JP, et al, “Relations among Menopausal symptoms, Sleep Disturbance and Depressive Symptoms in Midlife,”
Maturitas Feb 20, 2009; 62(2): 184-9
“Glucocorticoid Induced Osteoporosis,” Bone and Tooth Society of Great Britain, the National Osteoporosis Society and
the Royal College of Physicians (Pamphlet)
Reduced Risks for Hyperlipidemia
 Reduced Risks for all of the Age- and
Diabetes-related Chronic Inflammatory
Conditions

1.
2.
3.
Yaghoobi N, et al, “Natural Honey and Cardiovascular Risk Factors; Effects of Blood Glucose, Cholesterol,
Triacylglycerole, CRP, and Body Weight Compared to Sucrose,” Scientific World Journal 2008, April 20; : 463-9
“Antidiabetic Effect of Oligosaccharides in Honey – a Review,” Molecules 2012, 17:248-266
NS Al-Waili, MD, and NS Boni, “Natural Honey Lowers Plasma Prostaglandin Concentrations in Normal Individuals.” J
Med Food, 2003; 6(2): 129-33.

Improved cardiovascular health
1. Tengattini, S, et al, “Cardiovascular Diseases: Protective Effects of Melatonin.” J Pineal Res 2008 Jan; 44(1): 16-25
2. Chen Z, et al, “Protective Effect of Melatonin on Myocardial Infarction,” Am J Physiol Heart Circ Physiol (2003) 284:
H1618-H1624
3. MK Rakha, et al, “Cardioactive and Vasoactive Effects of Natural Wild Honey against Cardiac Malperformance Induced by
Hyperadrenergic Activity.” J Med Food Mar 2008; 11 (1): 91-98.
1.
2.
3.
4.
5.

Reducing cholesterol and triglyceride levels
and increasing HDL (good) cholesterol

Reducing inflammatory damage to blood
vessels (lowers prostaglandins)

Reducing homocysteine levels
Yaghoobi N, et al, “Natural Honey and Cardiovascular Risk Factors; Effects of Blood Glucose, Cholesterol, Triacylglycerole, CRP, and Body
Weight Compared to Sucrose,” Scientific World Journal 2008, April 20; : 463-9
Bogdanov, Sephan, “Honey in Medicine – A Review,” Bee Product Science, 5 April, 2011
“Antidiabetic Effect of Oligosaccharides in Honey – a Review,” Molecules 2012, 17:248-266
NS Al-Waili, MD, and NS Boni, “Natural Honey Lowers Plasma Prostaglandin Concentrations in Normal Individuals.” J Med Food, 2003; 6(2):
129-33.
El-Saleh, SC, “Honey Protects Against Homocysteine Elevation in Rats,” Vascular Disease Prevention, Vol 3, No 4, November 2006, 313-318(6)

Improved functional capacity for learning
and memory
1. LM Chepulis, NJ Starkey, et al, “The Effects of Long-term Honey, Sucrose or Sugar-free Diets on Memory and
Anxiety in Rats.” Physiol Behav 2009 Jun 22; 97(3-4):359-68.
2. JW Newcomer, et al, “Glucocorticoid-induced Impairment in Declarative Memory Performance in Adult Humans.” J
Neurosci (1994) 14, 2047-2053.
Keep fuel “in the tank”
4
HONEY initiates sleep and
ensures adequate brain fuel for
7 to 8 hours of recovery sleep
HONEY prevents METABOLIC STRESS
during the night, which
Improves sleep quality and duration
 Reduces the risk for all the metabolic
conditions associated with sleep
depravation* or interrupted sleep
 Increases REM (dream) sleep

* Less than 6 hours of sleep each night
Sleep Depravation or “Fractured”
Sleep is Associated with







Increased obesity
Increased insulin resistance and diabetes
Increase in rate of strokes by factor of 4
Accelerated memory loss and Alzheimer’s disease
Increased osteoporosis
Increase in heart disease and 48% increase in cardiacrelated deaths
Increased risk for colon cancer
1. D Johnson, MD, “Fractured Sleep Exacts a Heavy Toll.” Medscape February 19, 2014
2. AS Lim, et al, “Sleep Fragmentation and the Risk of Incident Alzheimer's Disease and Cognitive Decline in Older
Persons.” Sleep (2013) Jul 1; 36(7): 1027-1032.

A decrease in REM sleep with age is associated*
with these conditions and diseases:
Insomnia, depression, sleep apnea,
Alzheimer's disease, and other neurodegenerative diseases
*Association is not causation but can indicate the likelihood of an event or condition being related
to risk of another disease or condition



Reduced Risk for Sleep Disordered Breathing
(sleep apnea)
Reduced risks for Alzheimer’s disease,
Parkinsonism, and other Neuro-degenerative
diseases
Reduced risk for depression
1. H Mahboobi, et al, “Humanin: A Possible Linkage between Alzheimer's Disease and Type 2 Diabetes.” CNS Neurol Disord
Drug Targets (2013) Dec 22 [Epub ahead of print].
2. J Bloemer, et al, “Impaired insulin signaling and mechanisms of memory loss.” Prog Mol Biol Transl Sci (2014) 121: 41349.
3. AS Lim, et al, “Sleep Fragmentation and the Risk of Incident Alzheimer's Disease and Cognitive Decline in Older Persons.”
Sleep (2013) Jul 1; 36(7): 1027-1032.
4. Dinan TG, “Glucocorticoids and the Genesis of Depressive Illness: A Psychobiological Model.” Br J Psychiatry (1994) 164:
365-71
5. DA Axelson, et al, “Hypercortisolaemia and Hippocampal Changes in Depression.” Psychiat Res (1993) 47: 163-73.
The reduction or prevention of nocturnal
METABOLIC STRESS is the primary
benefit of consuming HONEY before
bedtime, impacting every system, organ, and
tissue in the body.
“Sleep with HONEY. . . Its good for your health!”
5
Additional Benefits of HONEY
HONEY improves immune system
function
Reduces symptoms of allergies
 Has powerful anti-cancer properties

1. Al-Waili, N, et al, “Effect of Honey on Antibody Production . . . In Primary and Secondary Immune Responses,” J Med Foods,
7(4) 2004, 492-495
2. Zidon, J, et al, “Prevention of Chemotherapy-Induced Neutropenia by special Honey Intake,” Medical Oncology 2006 , Vol 23,
No 4, 549-55
Honey stimulates the production of
antibodies, lymphocytes, monocytes and
other natural cancer killer cells
 Honey inhibits the production of cortisol
 Honey reactivates the mitochondria
 Honey inhibits the mutagenic ability of
cancer cells

1.
2.
3.
4.
J Zidan, et al, “Prevention of Chemotherapy-induced Neutropenia by Special Honey Intake.” Medical Oncology (2006) Vol 23, No 4, 549-552. First
published in American Journal of Clinical Nutrition (1998), Vol 67, 519S-526S.
N Al-Waili, MD, “Effect of Honey on Antibody Production Against Thymus-Dependent and Thymus-Independent Antigens in Primary and Secondary
Immune Responses.” Journal of Medicinal Foods 7 (4) 2004, 492–495.
AN Fauzi, et al, “Tualang Honey Induces Apoptosis and Disrupts the Mitochondrial Membrane Potential of Human Breast and Cervical Cancer Cell
Lines.” Food and Chemical Toxicology (2001) Vol 1, No 4, pp 871-878.
R Tomassin, et al, “Oral Administration of Aloe vera and Honey Reduces Walker Tumor Growth by Decreasing Cell Proliferation and Increasing
Apoptosis in Tumor Tissue.” Phytotherapy Research (2011) Vol 25, No 4, pp 619-623.
Topical Application of HONEY has
Powerful Antibiotic and Wound
Healing Benefits


1.
2.
3.
HONEY (at concentrations of only 3 to 16%) is
effective in killing over 60 of the most
pathogenic bacterial strains including MRSA
and other antibiotic-resistant strains
HONEY prevents the growth of biofilms which
inhibit wound healing
ZH Israili, “Antimicrobial Properties of Honey.” Am J Ther 2013 June 18.
S Blair, et al, “The Effect of Standard Heat and Filtration Processing Procedures on Antimicrobial Activity and Hydrogen Peroxide Levels in Honey.”
Front Microbiol 2012 Jul 27; 3: 265.
J Majtan, et al, “Anti-biofilm Effects of Honey Against Wound Pathogens P. mirabilis and E. cloacae.” Phytother Res Jan 28 2014; 28 (1): 69-75.
As an Antibiotic
HONEY reduces risks of gingivitis and
periodontal disease
 HONEY kills H pylori, the bacteria in the
stomach responsible for gastric ulcers
 Systemic use not effective

1.
S Aparna, et al, “A Comparative Evaluation of the Antibacterial Efficacy of Honey in Vitro and Antiplaque Efficacy in a 4-day Plaque Regrowth Model
in Vivo: Preliminary Results. J Periodontol (2012) Sep; 83(9): 1116-21.
HONEY reduces the inflammatory
processes that accompany aging
 HONEY improves sleep quality and
duration
 HONEY reduces the risk factors for the
conditions and diseases associated with
the metabolic syndrome

1.
NS Al-Waili, MD, and NS Boni, “Natural Honey Lowers Plasma Prostaglandin Concentrations in Normal Individuals.” J Med Food, 2003; 6(2): 12933.

The positive effect of HONEY consumption
on blood glucose seems to be more
consistent in older individuals and/or in
individuals with advanced glucose
intolerance due to progressive insulin
resistance

1.
Fructose from HONEY “recycles” the enzyme
in the liver necessary for detoxifying alcohol
Rang, HP, Dale MN, “Fructose Recycling of NAD from NADH,” Pharmacology, Churchill Livingstone 1991, Edinburgh Chapter 39, 890-1

HONEY regulates and controls blood sugar
and insulin levels

HONEY is the gold standard food for rapid
formation of liver glycogen, which is the
primary source of brain fuel

HONEY reduces or eliminates Metabolic
Stress

HONEY promotes Recovery Sleep

HONEY prevents disease for some, lowers
risks of disease for others, and improves or
restores health for all
The regular consumption of 3 to 5 tablespoons per day
of natural unfiltered HONEY* does all of this and
more without side effects, risks or negative health
consequences.
* Health benefit information from research studies used in this presentation relates to natural unfiltered
honey or specific honey varietals. Processed and blended honey may or may not provide similar benefits.
Further study is needed to determine if health benefits are applicable to processed honey.
The total direct and indirect costs for the diseases
and conditions associated with the metabolic
syndrome discussed in this presentation are over
$1 trillion / year in the United States and over $50
billion / year in Canada.
In other words, the population adjusted direct and indirect costs in
the U.S. are about double what they are in Canada with prevalence
rates being about the same in both countries (~20%).
A reduction in the prevalence of these diseases
by 1% translates to a $10 billion / year savings
in the U.S. and a $500 million / year savings in
Canada
- at a cost of less than $20 / month per person.
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TGBTGBooks.com, LLC
Available now at xulonpress.com/bookstore,
amazon.com & as eBook in most formats
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TGBTGBooks.com, LLC