Developing World Trauma Andrew Kestler, MD; Richard Fisher, MD & Matthew Roberts, MD University of Colorado December 2007 Prepared as part of an education project of the Global Health Education Consortium and collaborating partners Learning objectives 1. 2. 3. 4. Quantify the global burden of trauma Contrast unintentional vs violence-related trauma Describe the major factors driving trauma burden Discuss various trauma prevention strategies Focus on road traffic accidents & collective violence Discuss resource-appropriate trauma management Page 2 Learning Objectives Restated: A Public Health Approach to Trauma 1. 2. 3. 4. Determine the magnitude of the problem Identify factors that increase the risk of injury and determine which are modifiable Assess what measures can practicably be taken to reduce the risk Implement the most promising interventions on a broad scale Krug E, et al, Global burden of injuries, Am J Public Health. 2000;90:523-6 Page 3 Global Burden of Trauma • 5 million deaths/year related to trauma – 9% of world’s deaths – 12% of world’s burden of disease • Measured in DALYs (Disability Adjusted Life Years) • Road traffic accidents (RTAs) largest component Disease Control Priorities Project, Injuries & Violence Fact Sheet, April 2006, http://www.dcp2.org/file/7/DCPP-Injuries_Violence.pdf Page 4 Injury Leaders: Death & Disability • Top causes of death – 1. RTAs – 2. Self-Inflicted injury – 3. Interpersonal violence – 4. War • Top causes of lost DALYs – 1. RTAs – 2. War – 3. Interpersonal violence – 4. Self-Inflicted injury Page 5 Leading causes of injury death, by age High-Income Countries Low & Middle-Income Countries (all causes) (all causes) Age 5-14 RTAs (#1) Drowning (#3) Homicide (#4) Suicide (#5) RTAs (#2) Drowning (#3) Age 15-29 RTAs (#1) Suicide (#2) Homicide (#3) RTAs (#2) Suicide (#4) Homicide (#5) & War (#6) Age 30-44 Suicide (#1) RTAs (#2) RTAs (#3) Suicide (#5) Homicide (#6) Page 6 Trauma Burden: high risk groups • Children & young adults – Highest risk of death & disability (all injury causes) • Men (vs. women) – Homicide: 3:1 risk (6:1 at age 15-29) • Not including war deaths – RTAs: 5:2 risk of death • Low- & middle income countries (vs. high-income) – 2:1 risk of violence-related death – 1:1 risk of unintentional injury death • (but 90% of burden based on population) For a thorough and readable overview of both Unintentional Injuries and Interpersonal Violence, see Chapters 39 (Norton et al), and 40 (Rosenberg et al) in Disease Control Priorities in Developing Countries, Jamison Ed, World Bank & Oxford University Press, 2006, also available online at http://www.dcp2.org/pubs/DCP Disease Control Priorities in Developing Countries Page 7 Trauma Death Trends and Projections Source: Mathers & Loncar, 2006 Page 8 Unintentional Injuries • Includes – Burns – Drowning – Falls – Poisoning – Traffic Accidents • Focus on Road Traffic Accidents (RTAs), rationale: – Largest component of unintentional injuries in low- and high-income countries alike Page 9 Distribution of Unintentional Injuries Low- & Middle Income Countries, 2001 • Burden of disease is measured in DALYs (Disability Adjusted Life Years) • Source: Norton R, et al, Unintentional Injuries, in Disease Control Priorities for Developing Countries, Jamison Ed., World Bank & Oxford University Press, 2006 Page 10 Focus on RTAs • • Current – 2.1% global deaths (11th place) – 2.6% of global DALY’s lost (9th place) Projections for 2030 – 2.1 million deaths/year – 8th leading cause of death – 4th leading cause of DALYs (disability) – Largest increases anticipated in low & middle income countries due to economic & population growth Photo: Credit: (c) 2003 Sammy Ndwiga, Courtesy of Photoshare Caption: A catholic priest survives an automobile accident in Kenya. Ameratunga S, Hijar M, Norton R. Road-traffic injuries: confronting disparities to address a global-health problem. Lancet 2006; 367: 1533–40 Page 11 Road Traffic Accidents - Inequalities • Road traffic injury is a social equity issue • 30-86% of trauma admissions in low- & middle-income countries • RTA deaths mostly among “vulnerable road users”: – pedestrians, cyclists, motorized 2 wheelers, bus & minibus passengers • In high income countries the majority or RTAs involve cars, although vulnerable users remain at higher risk of dying if involved • Even in high income countries, the poor are more often the victims of RTAs, have less access to post crash health care and fewer socioeconomic resources to fall back on Amertunga, Hijar, & Norton, 2006 Page 12 Road fraffic injury mortality rates Page 13 Road Injury Prevention and Control The New Understanding from WHO • • • • • • “Road crash injury is largely preventable and predictable; it is a human made problem amenable to rational analysis and countermeasure Road safety is a multi-sectoral issue & a public health issue Common driving errors and common pedestrian behavior should not lead to death and serious injury The vulnerability of the human body should be the limiting design parameter for the traffic system Technology transfer from high income to low income countries needs to fit local conditions Local knowledge needs to inform the implementation of local solutions.” World Report on Road Traffic Injury Prevention, Peden M et al Ed. WHO 2004. http://www.who.int/violence_injury_prevention/publications/road_traffic/world_report/en/index.html Page 14 Drowning • In 2000, 409,272 people drowned (not including floods or tsunamis, water transport accidents, assaults or suicide) • 97% of these occurred in low and middle income countries (43% in India and China) • In low and middle income countries most cases of drowning are not recreation related but occur during necessary activities • Risk factors include – Male sex, young children, occupation (e.g., fishing), areas vulnerable to floods, unsafe transportation, alcohol, epilepsy, socioeconomic status, access to water WHO Drowning Fact Sheet 2003, at: http://www.who.int/violence_injury_prevention/publications/other_injury/en/drowning_factsheet.pd f Page 15 Burns • 322,000 Fire related deaths worldwide in 2002 – 12.2% in Africa – 57.2% in Southeast Asia • Leading cause of death in slums of Karachi • More than a million moderate to severe burns in India per year • Second most common injury in Nepal • Children at high risk WHO Burns Fact Sheet, 2004, at http://www.who.int/violence_injury_prevention/publications/other_injury/en/burns_factsheet.pdf Photos: Matthew Roberts, MD. An additional useful reference is: Ahuja RB, Bhattacharya S, ABC of burns: Burns in the developing world and burn disasters. BMJ 2004. 329 :447-9. WHO Burns Fact Sheet Page 16 Burns • • • • • • A leading cause of morbidity, disability, disfigurement and lengthy, prolonged and painful hospital course In many countries there is no burn service or burn specialist Treatment is often expectant – i.e, wait & see Optimal care is resource intensive: – Multiple surgeries, blood products, burn units, etc. In Australia a patient with an 80% burn is likely to survive with satisfactory function. In Nepal no patient with >40% survive WHO Burns Fact Sheet Page 17 Burns – Risk Factors • • • • • • • • • • Alcohol and smoking Open fires Floor level stoves Bedside fires Kerosene appliances Loose fitting clothing Violence against women Child abuse Inadequate child supervision Epilepsy WHO Burns Fact Sheet Page 18 Violence • In 2000 1.6 million people died from violence • 90+ % deaths in low or middle income countries • Types of violence – Self directed (e.g, suicide, suicide attempts) – Interpersonal (e.g, assaults, homicide) – Collective (e.g, War, other armed conflicts) • Factors influencing violence – Individual – Relationship – Community – Societal 191 million people lost their lives as a result of the 25 largest instances of collective violence in the 20th century; 60% were non-combatants. You can access the entire document at: http://www.who.int/violence_injury_prevention/violence/world_report/en/index.html Page 19 Violence • “The world does not have to accept (violence) as an inevitable part of the human condition” WHO 2002 • Increasingly recognized as global public health priority Page 20 Collective Violence • Wars, terrorism and other violent political conflicts that occur within or between states • State-perpetrated violence such as genocide, repression, disappearances, torture • Organized violent crime such as banditry and gang warfare • In top 5 causes of death, ages 5-44, African Region Page 21 Collective Violence: Associated problems • • • • Increased injury rate = more patients (civilian & military) Destruction of health care capacity Impaired access to care General loss of infra-structure • Communications • Road transport of supplies • Food availability • Water supply • Electricity Page 22 Example: Loss of Health Care Capacity • In the first 5 years of the armed internal conflict in Mozambique [1982 -1987] direct targeting of primary health facilities by the ‘bandits’ resulted in destruction of 31% of the entire health care system. • An equal percentage of health care workers were killed or displaced. Noormahomed AR, Cliff J: The impact on health in Mozambique of South African destabilization. Ministry of Health, Mozambique, 1987 Page 23 Example: Impaired Access to Care • Many injuries are in rural areas / most care facilities in cities. • No functioning emergency transport services • Transport in normal times is difficult, worse during conflicts • 75% of referrals never reach their destination Photo: Richard Fisher, MD Page 24 Injuries in war • Most of the injuries are now sustained by civilians • Penetrating trauma predominates over blunt trauma • High-velocity gunshot wounds and landmines Page 25 Civilian Victims • Military personnel often have separate hospitals - for their 10% of the injuries • Civilians account for 90% of injuries in developing countries - with few facilities • Informal fighters, militia groups, etc. often end up in civilian hospitals - most are cared for without questions Page 26 Injury Distribution • Experience from armed conflict in Rwanda – – – – – Extremity Back Abdomen Chest Head & Neck 62% 4% 15% 9% 10% [10% amputation rate] Sundin JA. War surgery in Kigali, Rwanda: The role of the International Committee of the Red Cross. Techniques in Orthopaedics 1995. 10:250-258 Page 27 Collective Violence Case: High-velocity gun shot wound • A 24 year-old male patient came to the emergency room. He had multiple gun shot wounds to his left leg including one in his left upper thigh - all seemed to have minimal soft tissue damage. • Vital signs are stable. He is alert. • What do you do? • See the supplementary notes for a discussion of the case Page 28 Landmines • Landmines are a current and future man-made disaster of an epidemic proportion - millions of mines scattered world wide with no means of removing them. • If you are in an region known to have landmines - ASK before you GO - into an unknown area. Don’t take the risk. • Improvised explosive devices (IEDs) a.k.a. “roadside bombs,” are more common than in many conflicts – More powerful & deadly than antipersonnel mines – Typically use abandoned armaments – Target vehicles: multiple casualties Page 29 Landmines • Since 1960, 110 million mines have been placed around the world - most remain active and dangerous. • The cost or making & placing a mine is <$75 • The cost of finding & removing a mine is $300 to $1000. Walsh NE, Walsh SW. Rehabilitation of landmine victims - the ultimate challenge. Bulletin WHO 81:665 - 670, 2003. Photo: Credit: (c) 2002 Sara A. Holtz, Courtesy of Photoshare Caption: "Danger - land mines": a warning on a billboard located just a few meters off the side of a road that leads out the capital of Guinea-Bissau. of For more information see the International Campaign to Ban Landmines: ICBL is a network of more than 1200 non-governmental organizations in 60 countries, working for a global ban on landmines. ICBL is also Co-laureate of the 1997 Nobel Peace Prize. www.icbl.org Page 30 Landmines • Types • Direct pressure - explode by being stepped on – These injure limbs, peroneal area, abdomen – Often result in amputations of one or both legs • Trip wire - above surface – Total body injury - usually a 50-yard killing range • Hand held - explode when picked up – Injure hands, arms and face - often cause blindness – These are often colorful to attract children Page 31 Landmines • Landmine and IED injuries are likely to be the worst injuries you encounter. – Explosion drives high-velocity foreign bodies [shrapnel & dirt] deep into tissues – Massive soft tissue destruction – Treatment is debridement - saving all living tissue - especially skin [to be used later for wound coverage] – Amputation frequently required Page 32 Landmine Ban • 1997 Ottawa Treaty to ban antipersonnel landmines – USA did not sign • Culmination of the efforts of The International Campaign to Ban Landmines – led by Nobel Peace Prize winner, Jody Williams • Many mines still exist, but ban may prevent many future injuries • …a good transition point to discuss injury prevention strategies Page 33 Prevention is better, and cheaper, than the cure • Can anything be done to reduce injury rates? • Only by eliminating the “accidents will happen” and “acts of God” mentality. What may appear to be random events are often predictable. • For injury to occur many compounding factors must be in place; the removal of just one factor may make all the difference and prevent unnecessary deaths and disabilities. Page 34 Injury Prevention • Public health interventions can be characterized in terms of three levels of prevention – Primary Prevention Reducing the likelihood of an event that may cause injury – Secondary Prevention Reducing the impact of an event that may cause injury – Tertiary Prevention Reducing mortality and morbidity through post event care Zwi A, Forjuoh S, Murugusampillay S , Odero W, Watts C Injuries in developing countries: policy response needed now. Trans R Soc Trop Med Hyg. 1996. 90,593-595 Page 35 Primary Prevention: Collective Violence: Reducing the risk of conflicts • Conflict prevention – Political dialogue – Economic development – Equalizing access to resources – Limiting rapid demographic changes • Conflict resolution – Supra-national organizations (UN, EU, OAS, etc.) – Peace enforcement and peace keeping (UN, NATO) For more on Geneva Conventions: http://www.icrc.org/Web/Eng/siteeng0.nsf/htmlall/genevaconventions Photos: Douglas Wilkinson, www.primarytraumacare.org Page 36 Secondary prevention: violence Reducing the impact & injuries from a war • • • • Laws of armed conflict: Geneva conventions Avoidance of collateral damage and non-combatant casualties Restrictions on Weapons of Mass Destruction Limit on “unnecessary” suffering – “It is prohibited to employ weapons, projectiles and material and methods of warfare of a nature to cause superfluous injury or unnecessary suffering.” (1977)* • Land mine ban • Body armor (for “high tech” militaries) • Resettlement & repatriation of displaced people (UNHCR) *1977 protocol 1 added to 1949 Geneva convention Page 37 Primary Prevention: RTAs Addressing The risk factors • • • • • • • • • • Regulate vehicle usage Separate pedestrians from vehicles Separate motor/non-motor vehicles Improve road design/maintenance Mandate vehicle maintenance Improve lighting Improve sign posting Remove road side hazards Enforce/create traffic regulations Control speed (e.g., speed bumps) Photo: Douglas Wilkinson, MD www.primarytraumacare.org Page 38 Secondary Prevention: RTAs Reducing the injuries from a given event • Address over-laden vehicles • Address unrestrained passengers • Require motor-cycle helmets • Implement crash protective design Photo: Matthew Roberts, MD Page 39 Tertiary Prevention Reducing mortality & morbidity through post event care • Same considerations for unintentional and violent trauma • Tertiary prevention = adequate trauma management • Any trauma care system is only as good as the weakest link in the chain of care – Retrieval of casualties (pre-hospital) – Assessment and resuscitation (in-hospital) – Surgery if indicated (in-hospital) – Nursing care (in-hospital) – Rehabilitation (long-term) Page 40 Contributing Factors: Pre-Hospital • Emergency Medical Systems – Poor emergency communication (no 911) – Poor road conditions – Few ambulances and/or transport personnel – Long transport times – Few can afford transport (fuel, maintenance & staff) “The Ambulance” Photo: Andrew Kestler, MD Page 41 Notes on: Contributing Factors: Pre-Hospital First aid training for the general population needs to targeted to those most likely to come across casualties e.g. commercial drivers and concentrate on the management of the most frequently seen injuries. There is little point in teaching Basic Life Support including CPR if the expected time to hospital is measured in hours or days. Husum et al described a pilot scheme in Northern Iraq and Cambodia where land mine injuries are frequent. 5000 lay people were trained in first aid, concentrating on control of peripheral hemorrhage. Subsequently paramedics received 450 hours of training. The mortality from land mine injuries dropped from 40% to 9%. Husum H, Mads G, Torben W, Van Heng Y, et al, Rural Prehospital Trauma Systems Improve Trauma Outcome in Low-Income Countries: A Prospective Study from North Iraq and Cambodia. Mil Med. 2003 Nov;168(11):934-40. Page 42 Contributing Factors: In-Hospital • Limited human & institutional capacity to manage trauma – Many hospitals without emergency department – Lack of trauma education – Lack of diagnostic and therapeutic tools – Lack of rapid OR access – Unsafe blood supply – Inappropriate equipment donation Page 43 Contributing Factors: Long-term Care • Limited capacity for ongoing treatment & rehabilitation – amputations & osteomyelitis common – limited access to prosthetics, wheelchairs, etc. – most environments unfriendly to the disabled Page 44 How the Factors Play Out Low – middle - & high-income cities Overall mortality for serious injuries: Kumasi 63%, Monterrey 55%, and Seattle 35% Mock CN, Jurkovich GJ, nii-Amon-Kotei D, Arreola-Risa C, Maier RV. Trauma mortality patterns in three nations at different economic levels: implications for global trauma system development. J Trauma. 1998.44:804-14. Page 45 Auto-triage & Trauma mortality • In high-income countries, Improved casualty retrieval may increase the severity of trauma seen at the hospital and paradoxically increase hospital mortality • Delays in arrival at hospital (especially in low- & middleincome countries) may result in “Auto-Triage”, decreasing the severity of cases seen and therefore mortality Kijabe Hospital is a rural hospital 50 km north of Nairobi, Kenya staffed by 3 general surgeons, 1 orthopedic surgeon, 4 family practitioners, 1 anaesthetist, I medical officer. There are 2 operating rooms, ashort term ICU; onward referral is to Nairobi. Otieno et al described 202 trauma patients in 6 months; the mean distance to hospital was 60km and the mean time to hospital was 9 hours. The overall mortality was 3.5, the mortality of those arriving < 2 hours was 9%, the mortality of those arriving > 2 < 24Hours was 1.3% and the mortality of those arriving > 24 hours was 1.4%. One implication is that those whose arrival at hospital is delayed may have been selected for survival. --- Otieno T, Woodfield JC, Bird P, Hill AG, Trauma in Rural Kenya. Injury. 2004 Dec;35:1228-33. Photo: Matthew Roberts, MD Page 46 Trimodal Distribution of Trauma Deaths • Basis for the “Golden Hour” concept & focus on early trauma care 50 45 40 35 30 25 20 15 10 5 0 Immediate Early (Hours) Late (Days-Weeks) Trunkey described, in the 1980’s, a trimodal distribution of civilian deaths from trauma the USA. Does this apply to the developing world? --- Trunkey DD, “Trauma,” Sci Am 1983, 249:28 Page 47 Golden Hour Realism • 4 weeks after the 2005 Kashmir Quake, 41 villages in Pakistan had not yet been accessed by the relief & rescue teams due to destroyed roads by the quake. • Often, trauma care in the first hour is far from realistic. • Consider: Silver Day? Bronze week? Photos and content from BBC website: http://news.bbc.co.uk/ Page 48 Tertiary Prevention: Pre-hospital Interventions • Increasing access to mobile phones/service worldwide may offset some communications issues • In Ghana most RTI casualties who reach hospital are transported in commercial vehicles – Intervention: first aid training for commercial drivers • Police & firefighters in urban areas often first on scene – Intervention: first aid training for police & firefighters Mock et al conducted a study in Ghana to improve pre-hospital trauma care by training bus & truck drivers No formal EMS system in Ghana Commercial drivers often first responders 335 drivers trained in 6-hr first aid course Survey of 70 drivers after 11 months (avg) 61% had been involved in first aid Self-reported improvement in: Scene management, airway opening, external bleeding control, & splinting of extremities Mock CN, Tiska M, Adu-Ampofo M, Boakye G.Improvements in prehospital trauma care in an African country with no formal emergency medical services. J Trauma. 2002. 53:90-7 Page 49 Trauma management & training (in-hospital tertiary prevention) • Advanced Trauma Life Support (ATLS) is ubiquitous in most developed countries, so that is difficult to assess its impact. • Institution of ATLS in the Netherlands: – One study showed decrease in mortality within 1 hour • This is the “Golden Hour” in which ATLS targets. • Difficult to show effect on overall mortality because of many other links in the chain of trauma care Van Olden et al, “Clinical impact of ATLS”. Am J Emerg Med 2004. 22:522-5. Page 50 A casualty being managed according to ATLS guidelines This patient has an endotracheal tube to maintain his airway (A) and allow positive pressure ventilation (B). The cervical spine is immobilized in a hard collar. He has chest tubes in place and one way seals placed over chest wounds (B). There are two large bore cannulae and a transfusion is in progress (C). A secondary survey is in progress to identify other injuries (E). Photo: Matthew Roberts, MD Page 51 ATLS in the Developing World • Trauma outcome improves following the ATLS program in a developing country. – Ali, Trinidad and Tobago • Mortality 33.5% post ATLS vs. 67.5% pre-ATLS • Mortality decreased in all wards of the hospital • Decreased major disability, increased minor disability • But: ATLS is costly & designed for centers without restricted resources Ali J, Adam R, Stedman M, Howard M, Williams JI. Advanced trauma life support program increases emergency room application of trauma resuscitative procedures in a developing country. Journal of Trauma 1993, 34: 898-899 Page 52 Resource Appropriate Trauma Management • Various organization have developed trauma care courses or manuals suited to resource-poor settings – WHO: Best Practice Guidelines on Emergency Surgical Care in Disaster Situations – WHO: Guidelines for Essential Trauma Care – Primary Trauma Care: Course and manual with focus on training the trainers for rapid dissemination – Locally developed/adapted curricula Page 53 Major Incidents - Multiple Casualties & Triage • A major incident is one that outstrips normally available resources • Usually involves more than just the medical services • Infrastructure damage, physical and societal, may affect ability to respond • Triage, the prioritizing of patients according to severity of injury and urgency of care, seldom required in well staffed western hospitals • Essential where resources are limited • See supplementary notes for a case study! Page 54 Tertiary Prevention: Rehabilitation • Prevention of early death may lead to increased morbidity in the community • In some societies disability is a worse outcome than death, both economically and socially Photo: Douglas Wilkinson, MD www.primarytraumacare.org Page 55 Rehabilitation • Often an overlooked aspect of healthcare in developing countries. • It involves both: – Rehabilitation for acute problems - fractures/amputations – Community based rehabilitation of chronic problems • Disability post-trauma • Disability from cerebral palsy, strokes, & polio One resource for Rehabilitation in low and middle income countries is David Werner”s book on community based rehabilitation for disabled children, “Disabled Village Children”. David Werner is also the author of the widely translated and disseminated book “Where there is no doctor”. See: http://www.hesperian.org/mm5/merchant.mvc?Screen=PROD&Store_Code=HB&Product_Code=B040&Cat egory_Code=ENG Page 56 Rehabilitation Acute Problems/Amputations • The decision to amputate an extremity is usually based on the condition of: – Vascular supply – Nerve - sensation / motor function – Skin - coverage of the stump – Soft tissue viability - muscle – Bone – Presence of infection • To amputate or not? – What do you need as an outcome ? – How can you achieve the desired outcome? From Sundin J, 1995 Page 57 Rehabilitation - Amputation Considerations • Amputees need prostheses to be employable in developing countries. • In some cultures an amputation is socially unacceptable. • Prostheses are expensive or not available in most places. • They need to be replaced continually as they wear out. A mine accident victim has his amputated leg freshly bandaged at an hospital in Cambodia. Photo: Credit: (c) 2003 Marcel Reyners, Courtesy of Photoshare Page 58 Rehabilitation – Prosthetics • Most countries are developing programs to manufacture artificial limbs and to train personnel. • Agencies involved include: • The International Committee of the Red Cross • Handicap International • World Vision • Many others • Most programs try to use locally available materials Page 59 Rehabilitation – Prosthetics Photos: Richard Fisher, MD Page 60 Summary of Key Points • For older children & young adults, trauma is the leading cause of death and disability worldwide • Trauma can be either violent or unintentional • Road traffic accidents = largest single cause • The best way to reduce the trauma burden: prevention • Education & other basic measures can improve trauma care in developing countries Page 61 General References Papers See supplementary notes for cited papers. Books Disease Control Priorities in Developing Countries, Jamison DT et al Ed, World Bank & Oxford University Press, 2006, also available online at http://www.dcp2.org/pubs/DCP See supplementary notes for cited books. Web links See supplementary notes for suggested web links. Page 62 Credits Dr. Andrew Kestler, MD Division of Emergency Medicine U. of Colorado Denver, School of Medicine Dr. Matthew Roberts, BM, BCh Department of Anesthesiology U. of Colorado Denver, School of Medicine Dr. Richard Fisher, MD Department of Orthopedics U. of Colorado Denver, School of Medicine Page 63 The Global Health Education Consortium gratefully acknowledges the support provided for developing these teaching modules from: Sponsors Margaret Kendrick Blodgett Foundation The Josiah Macy, Jr. Foundation Arnold P. Gold Foundation This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.
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