Researchers
Researchers
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Engaged
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Engaged
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QUEST
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Shriners
Shriners
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Shriners
Hospitals
Hospitals
for Children
for Children
for –Children
Northern
– Northern
– Northern
California
California
California
is home
is home
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is the
home
toInstitute
the
to Institute
the of
Institute
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of Pediatric
of Pediatric
Regenerative
Regenerative
Regenerative
Medicine
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Medicine
(IPRM),
(IPRM),
(IPRM),
a collaborative
a collaborative
a collaborative
initiative
initiative
initiative
of Shriners
of Shriners
of Hospitals
Shriners
Hospitals
Hospitals
for Children
for Children
for and
Children
the
andUniversity
and
the University
the University
of California,
of California,
of California,
DavisDavis
School
Davis
School
ofSchool
Medicine.
of Medicine.
of Medicine.
2425 2425
Stockton
2425
Stockton
Stockton
Boulevard,
Boulevard,
Boulevard,
Sacramento,
Sacramento,
Sacramento,
CA 95817
CA 95817
CA
ÊU (916)
95817
ÊU (916)
453-2000
ÊU (916)
453-2000
453-2000
ÊU www.shrinershospitalsforchildren.org
ÊU www.shrinershospitalsforchildren.org
ÊU www.shrinershospitalsforchildren.org
ÊU www.iprmd.org
ÊU www.iprmd.org
ÊU www.iprmd.org
AAA
nyonenyone
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nyone
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knows
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hope
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The dream
The The
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a is a is a
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real real
At
one.Shriners
one.
At Shriners
At Shriners
Hospitals
Hospitals
Hospitals
for Children
for Children
for Children
– Northern
– Northern
– Northern
California,
California,
California,
doctors
doctors
and
doctors
scientists
and and
scientists
scientists
workworkwork
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collaboratively
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heal
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Research
Research
Research
studies
studies
are
studies
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are headquartered
are headquartered
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in Institute
the Institute
of Pediatric
of Pediatric
of Pediatric
Regenerative
Regenerative
Regenerative
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(IPRM),
(IPRM),
(IPRM),
a joint
a joint
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ofproject
Shriners
of Shriners
of Shriners
Hospitals
Hospitals
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for Children
for Children
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and the
andUniversity
and
the University
the University
of California,
of California,
of California,
DavisDavis
School
Davis
School
ofSchool
of of
Medicine.
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Located
Located
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Located
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Northern
the Northern
the Northern
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Shriners
Shriners
Shriners
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the IPRM
the IPRM
the
is IPRM
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international
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Is theIsability
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effective
drug
therapies?
drug
therapies?
therapies?
We doWe
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assured
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lives
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generations
generations
generations
to come.
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DavidDavid
Pleasure,
David
Pleasure,
Pleasure,
M.D.M.D.
M.D.
Director
Director
Director
of Research
of Research
of Research
Shriners
Shriners
Shriners
Hospitals
Hospitals
Hospitals
for Children
for Children
for Children
– Northern
– Northern
– Northern
California
California
California
Research
Research
Research
Provides
Provides
Provides
New
New
New
Hope
Hope
Hope
For
For
Children
For
Children
Children
Scientific
Scientific
Scientific
and clinical
and clinical
andresearch
clinical
research
studies
research
studies
provide
studies
provide
new
provide
hope
new new
hope
for children
hope
for children
forwith
children
cerebral
withwith
cerebral
palsy,
cerebral
palsy,
spina
palsy,
spina
bifida,
spina
bifida,
brachial
bifida,
brachial
brachial
plexusplexus
birth
plexus
palsy,
birthbirth
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cleftpalsy,
lip
cleft
and
cleft
lippalate,
and
lip palate,
and
burns,
palate,
burns,
spinal
burns,
spinal
cord
spinal
injuries
cordcord
injuries
and
injuries
other
and other
and
pediatric
other
pediatric
conditions.
pediatric
conditions.
conditions.
DavidDavid
Pleasure,
David
Pleasure,
Pleasure,
M.D.,M.D.,
a neurologist
M.D.,
a neurologist
a neurologist
and Director
and Director
andof
Director
Research
of Research
of Research
at Shriners
at Shriners
atHospitals
Shriners
Hospitals
Hospitals
for Children
for Children
for –Children
Northern
– Northern
– California,
Northern
California,
California,
leads leadsleads
teamsteams
of researchers
in their
for cures.
teams
of researchers
of researchers
in quest
their
in their
quest
quest
for cures.
for cures.
BoneBone
Abnormalities
Bone
Abnormalities
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Cerebral
Cerebral
Cerebral
PalsyPalsy
Palsy
Scientists
Scientists
Scientists
knowknow
thatknow
bone
that that
bone
development
bone
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development
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and turnover Cerebral
Cerebral
palsy
Cerebral
palsy
occurs
palsy
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in approximately
occurs
in approximately
in approximately
1 in every
1 in 1every
300
in every
300 300
are regulated
are regulated
are regulated
by thebyimmune
the
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thesystem.
immune
system.
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orthopaedic
While
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children
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born
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inUnited
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the
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States.
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symptoms
While
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surgeon,
surgeon,
Jenny
surgeon,
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Boakes,
Jenny
Boakes,
M.D.,
Boakes,
M.D.,
constructs
M.D.,
constructs
constructs
improved
improved
improved
vary, vary,
cerebral
vary,
cerebral
palsy
cerebral
palsy
often
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affects
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ability
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ability
to ability
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methods
methods
to
methods
repair
to repair
bone
to repair
bone
malformations
bone
malformations
malformations
in children,
in children,
in Iannis
children,
Iannis
Iannis
walk walk
normally
walk
normally
and
normally
other
and other
and
motor
other
motor
skills.
motor
skills.
In skills.
theInShriners
the
InShriners
the Shriners
Adamopoulos,
Adamopoulos,
Adamopoulos,
Ph.D.,Ph.D.,
examines
Ph.D.,
examines
examines
immune
immune
regulation
immune
regulation
regulation Hospital
Hospital
high-tech
Hospital
high-tech
high-tech
Motion
Motion
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Anita
Lab,Lab,
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Bagley,
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Bagley,
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abnormalities
abnormalities
abnormalities
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that that
cause
bone
cause
bone
loss bone
inloss
children
loss
in children
inand
children
and and
Ph.D.,Ph.D.,
M.P.H.,
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a M.P.H.,
biomedical
a biomedical
a biomedical
engineer,
engineer,
engineer,
and Jon
andDavids,
Jon
and Davids,
Jon Davids,
recurrent
recurrent
bone
recurrent
bone
overgrowth
bone
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after limb
afterafter
amputation.
limblimb
amputation.
amputation.
M.D.,M.D.,
an orthopaedic
M.D.,
an orthopaedic
an orthopaedic
surgeon,
surgeon,
use
surgeon,
motion
use motion
use
sensors
motion
sensors
and
sensors
and and
three-dimensional
three-dimensional
three-dimensional
images
images
to images
testtothe
test
to
effectiveness
the
testeffectiveness
the effectiveness
of of of
various
various
therapies
various
therapies
for
therapies
improved
for improved
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function
function
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children
in children
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children
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Brachial
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Plexus
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clinical
The The
clinical
research
clinical
research
isresearch
complemented
is complemented
is complemented
by by by
cerebral
cerebral
palsy.
cerebral
palsy.
Nerves
Nerves
to Nerves
thetoarms
the
toarms
and
the neck
arms
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neck
andsometimes
neck
are sometimes
are sometimes
rippedripped
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ripped
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scientific
scientific
studies
studies
into
studies
the
intopossible
into
the possible
theuse
possible
ofuse
drugs
of
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that
of drugs
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in newborns
in newborns
in newborns
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large
to permit
to
easy
permit
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easyeasy
delivery
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delivery
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prevent
the
prevent
development
the development
the development
or theoreffects
the
oreffects
the
of effects
cerebral
of cerebral
ofpalsy.
cerebral
palsy.
palsy.
the birth
the canal.
birth
the birth
canal.
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resulting
The The
resulting
diagnosis
resulting
diagnosis
diagnosis
is Brachial
is Brachial
is Brachial
PlexusPlexus
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an injury
Palsy,
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that
an injury
occurs
that that
occurs
in occurs
roughly
in roughly
in2.5
roughly
2.5 2.5
out ofout
every
of
outevery
1,000
of every
1,000
births.
1,000
births.
Surgery
births.
Surgery
isSurgery
often
is often
required
is often
required
torequired
to to CleftCleft
LipCleft
&Lip
Palate
Lip
& Palate
& Palate
restore
restore
a child’s
restore
a child’s
ability
a child’s
ability
to reach
ability
to reach
an
toobject
reach
an object
an
or throw
object
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aor throw
a a Approximately
Approximately
Approximately
1 out 1ofout
every
1 of
outevery
700
of every
children
700 700
children
ischildren
born
is with
born
is born
withwith
ball. Pediatric
ball.ball.
Pediatric
hand
Pediatric
hand
surgeon,
hand
surgeon,
Andrea
surgeon,
Andrea
Bauer,
Andrea
Bauer,
M.D.,
Bauer,
M.D.,
is M.D.,
is is cleft lip
cleft
and/or
cleft
lip and/or
lip
cleft
and/or
palate.
cleftcleft
palate.
Konstantinos
palate.
Konstantinos
Konstantinos
Zarbalis,
Zarbalis,
Ph.D.
Zarbalis,
Ph.D.
Ph.D.
organizing
organizing
organizing
a multi-center
a multi-center
a multi-center
trial totrial
compare
trial
to compare
to the
compare
effectivethe effectivethe effective-investigates
investigates
investigates
the genetic
the genetic
thecauses
genetic
causes
of causes
cleft
of lip,
cleft
ofcleft
cleft
lip, palate
cleft
lip, cleft
palate
andpalate
and and
ness of
ness
different
ness
of different
of methods
different
methods
for
methods
repairing
for repairing
for nerves
repairing
nerves
in nerves
theinarms
the
inarms
the arms
brain brain
malformations.
brain
malformations.
malformations.
His investigations
His investigations
His investigations
have uncovered
havehave
uncovered
uncovered
of injured
of injured
of
infants.
injured
infants.
Peter
infants.
Peter
Bannerman
Peter
Bannerman
Bannerman
Ph.D.,Ph.D.,
develops
Ph.D.,
develops
develops a genetic
a genetic
link
a genetic
tolink
cleft
link
to lip
cleft
toand
cleft
lipcleft
and
lip palate
cleft
and cleft
palate
in mice,
palate
in mice,
and
in mice,
his
and his
and his
graftsgrafts
thatgrafts
contain
that that
contain
engineered
contain
engineered
engineered
human
human
bone
human
bone
marrow
bone
marrow
stem
marrow
stemstem
work work
maywork
lead
mayto
may
lead
improved
lead
to improved
to improved
genetic
genetic
testing
genetic
testing
of testing
families
of families
ofatfamilies
at at
cells that
cellsare
cells
thatdesigned
that
are designed
are to
designed
improve
to improve
tothe
improve
outcome
the outcome
the of
outcome
of of
risk ofrisk
having
risk
of having
of
children
having
children
with
children
these
withwith
these
disorders.
these
disorders.
disorders.
surgery
surgery
insurgery
these
in these
infants.
in these
infants.
infants.
Ż Hand
Ż Hand
Ż
Function
Hand
Function
Function
Michelle
Michelle
James
Michelle
James
M.D.,
James
M.D.,
Chief
M.D.,
Chief
of Orthopaedics,
Chief
of Orthopaedics,
of Orthopaedics,
develops
develops
new
develops
tests
new new
and
testsnew
tests
andprocedures
new
and new
procedures
procedures
to enhance
to enhance
to enhance
functional
functional
functional
recovery
recovery
from
recovery
from
handfrom
hand
malformations
hand
malformations
malformations
and injuries.
and injuries.
andIfinjuries.
successful,
If successful,
If successful,
the studies
the studies
the
will
studies
help
will will
helphelp
restore
restore
therestore
gift
theofgift
the
grip.
of
giftDr.
grip.
ofJames
grip.
Dr. James
Dr.
hasJames
directed
has directed
has directed
the development
the development
the development
of a model
of a of
model
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usesuses
motion
motion
analysis
analysis
toanalysis
evaluate
to evaluate
tothe
evaluate
activity
the activity
theofactivity
theofthumb
the
ofthumb
the
in thumb
in in
children
children
who
children
have
whowho
congenital
havehave
congenital
congenital
thumbthumb
problems.
thumb
problems.
problems.
The techniques
The The
techniques
techniques
provide
provide
precise
provide
precise
measurements
precise
measurements
measurements
that make
that that
make
it possible
make
it possible
ittopossible
measure
to measure
tothe
measure
effects
the effects
the effects
of different
of different
of treatment
different
treatment
treatment
strategies
strategies
strategies
and, in
and,
turn,
and,
in turn,
in turn,
identify
identify
surgical
identify
surgical
techniques
surgical
techniques
techniques
and physical
and physical
and physical
therapy
therapy
that
therapy
can
thatimprove
that
can improve
canthe
improve
grip
theand
grip
thedexterity
grip
and dexterity
and dexterity
in children
in children
inwith
children
thumb
withwith
thumb
deficiency.
thumb
deficiency.
deficiency.
Spinal
Spinal
Cord
Spinal
Cord
Injury
Cord
Injury
Injury
Approximately
Approximately
Approximately
12,000
12,000
cases
12,000
casescases
of spinal
of spinal
cord
of spinal
injury
cordcord
injury
are injury
reported
are reported
are reported
in theinUnited
the
inUnited
the
States
United
States
each
States
year.
eacheach
year.year.
Researchers
Researchers
Researchers
at Shriners
at Shriners
atHospitals
Shriners
Hospitals
Hospitals
for Children
for Children
for hope
Children
hope
to find
hope
toafind
way
to find
ato
way
a way
to to
heal spinal
heal heal
spinal
cord
spinal
injury,
cordcord
injury,
so injury,
children
so children
soparalyzed
children
paralyzed
paralyzed
by injury
by injury
by injury
can walk
can walk
again.
can walk
again.
Studies
again.
Studies
byStudies
Makoto
by Makoto
byHoriuchi,
Makoto
Horiuchi,
Horiuchi,
Ph.D.Ph.D.
andPh.D.
and and
Veronica
Veronica
Martinez-Cerdeno,
Veronica
Martinez-Cerdeno,
Martinez-Cerdeno,
Ph.D.Ph.D.
focus
Ph.D.
focus
on spinal
focus
on spinal
on
cord
spinal
cordcord
repair.repair.
Dr.repair.
David
Dr. David
Dr.
Pleasure
David
Pleasure
develops
Pleasure
develops
novel
develops
novel
therapies
novel
therapies
to
therapies
to to
Ÿ Neural
Ÿ Neural
Ÿ Development
Neural
Development
Development
prevent
prevent
damage
prevent
damage
to
damage
spinal
to
spinal
cord
to
spinal
function
cord
cord
function
caused
function
caused
by
caused
by
by
WhenWhen
nerves
When
nerves
to nerves
thetolimbs
the
tolimbs
the
are limbs
severed
are severed
areinsevered
infants
in infants
in
and
infants
and and
inflammation
inflammation
inflammation
that may
that occur
that
maymay
occur
afteroccur
immunizations
afterafter
immunizations
immunizations
and and and
children,
children,
the
children,
neurons
the neurons
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neurons
give
that rise
that
giveto
give
rise
these
to
risethese
nerves
to these
nerves
nerves
or
as
a
component
or
as
a
component
of
diseases
of
such
diseases
as
viral
infections
viral
viral
infections
infections
or
as
a
component
of
diseases
suchsuch
as as
die. Drs.
die. die.
Takayuki
Drs. Drs.
Takayuki
Takayuki
and Aki
andIto
Aki
and
discovered
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Ito discovered
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a protein
a protein
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sclerosis.
multiple
sclerosis.
multiple
sclerosis.
responsible
responsible
responsible
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this
for neuronal
this death
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Doctors
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Doctors
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at Shriners
at Shriners
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–
– –
Northern
Northern
Northern
California
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are responsible
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Organ
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One
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Cho,
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drugs.
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Working
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children.
Environmental
Environmental
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Tina Palmieri,
TinaTina
Palmieri,
Palmieri,
M.D.,M.D.,
Assistant
M.D.,
Assistant
Assistant
ChiefChief
of Chief
of of
Burns,
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crafts
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Diagnostics
Diagnostics
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Soman
Soman
Sen,
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Sen,
M.D.
Sen,
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burn
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His research
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The
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Investigators
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Scientific
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at Shriners
at Shriners
atHospitals
Shriners
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for Children
for--Children
Northern
-- Northern
--California
Northern
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are are
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theInstitutes
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theScience
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the National
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theMultiple
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for Regenerative
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Iannis Iannis
Adamopoulos,
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Adamopoulos,
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uses human
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Veronica
Veronica
Martinez-Cerdeno,
Veronica
Martinez-Cerdeno,
Martinez-Cerdeno,
Ph.D., Ph.D.,
is Ph.D.,
is
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cause
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David David
Greenhalgh,
David
Greenhalgh,
Greenhalgh,
M.D., investigates
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children
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Anita Bagley,
AnitaAnita
Bagley,
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Ph.D.,
M.P.H.
Ph.D.,
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M.P.H.
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David David
Pleasure,
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to the
delivery
to theto the
of critically
of critically
burned
of critically
burned
children
burned
children
to evaluate
children
to evaluate
their
to evaluate
their their
brain ofbrain
prematurely
brain
of prematurely
of prematurely
born infants
born infants
born
- a major
infants
- a cause
major
- a major
causecause
Peter Bannerman,
PeterPeter
Bannerman,
Bannerman,
Ph.D., Ph.D.,
develops
Ph.D.,
develops
grafts
develops
that
graftsgrafts
that that
heart and
heart
kidney
heart
and kidney
function.
and kidney
function.
In function.
this way,
In thishe
Inway,
this
willhe
way,
will
he will
for cerebral
for cerebral
palsy.
for cerebral
Using
palsy.palsy.
newborn
UsingUsing
newborn
mice,
newborn
Dr.
mice,
Guo
mice,
Dr. Guo
Dr. Guo
containcontain
engineered
contain
engineered
human
engineered
human
bone human
marrow
bone marrow
bone
stemmarrow
stem stem
be ablebe
to able
continuously
betoable
continuously
to continuously
evaluate
evaluate
the evaluate
clinical
the clinical
the clinical
investigates
investigates
the
investigates
biochemical
the biochemical
the biochemical
basis for
basis
susceptibasis
for susceptifor suscepticells designed
cells designed
cells
to improve
designed
to improve
surgical
to improve
surgical
outcomes
surgical
outcomes
in outcomes
in in
appropriateness
appropriateness
appropriateness
of the fluid
of theand
offluid
the
drug
and
fluid
therapies
drug
and therapies
drug therapies
bility tobility
this bility
damage.
to thistodamage.
this damage.
infants infants
who suffer
infants
who nerve
suffer
who suffer
damage
nervenerve
damage
in their
damage
inarms
their
in arms
their arms
these children
these these
children
receive.
children
receive.
receive.
due to difficult
due todue
difficult
deliveries.
to difficult
deliveries.
deliveries.
Makoto
Makoto
Horiuchi,
Makoto
Horiuchi,
Ph.D.,
Horiuchi,
Ph.D.,
investigates
Ph.D.,
investigates
the
investigates
the the
Jiho Sohn,
Jiho Ph.D.,
Sohn,
Jiho Sohn,
Ph.D.,
is investigating
Ph.D.,
is investigating
is investigating
the therapeutic
the therapeutic
the therapeutic
effectiveness
effectiveness
effectiveness
of grafting
of grafting
immature
of grafting
immature
neural
immature
cells
neuralneural
cells cells
Jennette
Jennette
(Jenny)
Jennette
(Jenny)
Boakes,
(Jenny)
Boakes,
M.D.,
Boakes,
is
M.D.,
an M.D.,
is an is an
benefitsbenefits
of pigment
benefits
of pigment
epithelial-derived
of pigment
epithelial-derived
epithelial-derived
factor factorfactor
as therapy
as therapy
for
asinjuries
therapy
for injuries
and
for diseases
injuries
and diseases
and
of the
diseases
of theof the
orthopaedic
orthopaedic
surgeon
orthopaedic
surgeon
whosurgeon
devises
who devises
who
improved
devises
improved
improved
(PEDF),
(PEDF),
a protein
(PEDF),
a protein
known
a protein
known
to control
known
to control
blood
to control
vessel
bloodblood
vesselvessel
nervousnervous
system.
nervous
system.
Sometimes
system.
Sometimes
these
Sometimes
neural
these these
cells
neuralneural
cells cells
methods
methods
to repair
methods
to bone
repair
to malformations
repair
bone malformations
bone malformations
in children.
in children.
in children.
formation.
formation.
Dr.
formation.
Sohn
Dr.discovered
Sohn
Dr. Sohn
discovered
that
discovered
PEDF
that PEDF
that PEDF
can be can
obtained
becan
obtained
from
be obtained
autopsied
from autopsied
from
brains,
autopsied
brains,
but this
brains,
but this
but this
therapytherapy
enhances
therapy
enhances
theenhances
repair
the of
repair
the
experimental
repair
of experimental
of experimental
Laura Laura
Borodinsky,
Laura
Borodinsky,
Borodinsky,
Ph.D., Ph.D.,
has obtained
Ph.D.,
has obtained
has
novel
obtained
novelnovel
source source
is limited
source
is limited
andis the
limited
and
health
the
and
of
health
the
these
health
ofcells
these
of these
cells cells
spinal cord
spinal
and
spinal
cord
brain
and
cord
lesions.
brain
and brain
lesions.
He islesions.
working
He is He
working
is working
evidence
evidence
thatevidence
folate
thatincreases
folate
that folate
increases
theincreases
ability
the ability
ofthe
cells
ability
of cells
of
cells varies.
varies.
Newvaries.
techniques
New techniques
Newpermit
techniques
permit
the generation
permit
the generation
the generation
out PEDF
out treatments
PEDF
out PEDF
treatments
for
treatments
future
for application
future
for future
application
toapplication
to to
on the two
on the
sides
ontwo
the
ofsides
two
the spinal
sides
of theof
cord
spinal
thetospinal
cord
fuse to
cord
fuseto fuseof immature
of immature
of
neural
immature
cells
neuralfrom
neural
cellsskin-derived
from
cells skin-derived
from skin-derived
stem stem stem
childrenchildren
withchildren
neurological
with neurological
with neurological
diseases.
diseases.
diseases.
togethertogether
andtogether
prevent
and prevent
spina
and prevent
bifida.
spina spina
bifida.
It is known
bifida.
It is known
It is known
cells. Dr.
cells.
Horiuchi
cells.
Dr. Horiuchi
Dr.
compares
Horiuchi
compares
thecompares
effectiveness
the effectiveness
the effectiveness
that adding
that adding
folic
that adding
acid
folic
(a acid
folic
vitamin)
(aacid
vitamin)
to(athe
vitamin)
maternal
to thetomaternal
the maternal
of theseoftwo
these
of
cell
these
two
sources
cell
twosources
in
cellrepairing
sources
in repairing
the
in repairing
spinal
the spinal
the spinal
Tina Palmieri,
Tina Tina
Palmieri,
M.D.,
Palmieri,
aM.D.,
burnM.D.,
surgeon,
a burna surgeon,
burn
designs
surgeon,
designs
designs
diet diminishes
diet diminishes
dietthe
diminishes
frequency
the frequency
theoffrequency
spinaofbifida,
spina
of spina
bifida,bifida,
cords and
cords
brains
cords
and of
brains
and
genetically-altered
brains
of genetically-altered
of genetically-altered
mice. mice.mice.
strategies
strategies
to strategies
mitigate
to mitigate
environmental
to mitigate
environmental
environmental
factors factors
that factors
that that
but howbut
folate
how
butdoes
folate
howthis
folate
does
remains
this
doesremains
this
mysterious.
remains
mysterious.
mysterious.
slow the
slow
recovery
the
slowrecovery
the
of children
recovery
of children
after
of children
severe
after severe
burns.
after severe
burns.burns.
Dr. Borodinsky’s
Dr. Borodinsky’s
Dr. Borodinsky’s
findingsfindings
are findings
based
areon
based
are based
on on Takayuki
Takayuki
Ito,
Takayuki
M.D.,
Ito, Ph.D.
M.D.,
Ito, M.D.,
&
Ph.D.
AkiPh.D.
&
ItoAki
Ph.D.,
&Ito
AkiPh.D.,
Ito Ph.D.,
AthenaAthena
Soulika,
Athena
Soulika,
Ph.D.,
Soulika,
Ph.D.,
an immunologist,
Ph.D.,
an immunologist,
an immunologist,
microscopic
microscopic
microscopic
observations
observations
observations
of the developing
of theofdeveloping
the developing
are investigating
are investigating
are investigating
ways toways
prevent
ways
to prevent
motor
to prevent
motormotor
focusesfocuses
on the
focuses
role
on the
ofonrole
inflammatory
theofrole
inflammatory
of inflammatory
cells incells in
cells in
frog spinal
frog cord.
spinal
frog spinal
cord. cord.
neuronneuron
deathneuron
that
death
may
death
that
occur
may
thatwhen
occur
may nerves
occur
whenwhen
nerves
to nerves
to to
spinal cord
spinal
and
spinal
cord
skin
and
cord
burn
skin
and
repair.
burn
skin repair.
burn repair.
the limbs
theare
limbs
the
severed
limbs
are severed
in
areinfants
severed
in infants
andinchildren.
infants
and children.
and children.
Kiho Cho,
KihoD.V.M.,
Kiho
Cho, Cho,
D.V.M.,
Ph.D.,
D.V.M.,
Ph.D.,
worksPh.D.,
in
works
conjunction
works
in conjunction
in conjunction
They discovered
They They
discovered
adiscovered
protein
a protein
responsible
a protein
responsible
for
responsible
for forKonstantinos
Konstantinos
Konstantinos
Zarbalis,
Zarbalis,
Ph.D.,
Zarbalis,
Ph.D.,
investigates
Ph.D.,
investigates
the
investigates
the the
with Dr.
with
David
Dr.
withGreenhalgh,
David
Dr. David
Greenhalgh,
Greenhalgh,
Chief of
Chief
Burns,
Chief
of Burns,
to of Burns,
to to
this nerve
thisdamage
nerve
this nerve
damage
and damage
areand
investigating
are
andinvestigating
are investigating
the
the the
geneticgenetic
causes
genetic
causes
of cleft
causes
of
lip/cleft
cleft
of lip/cleft
cleft
palate
lip/cleft
and
palate
brain
palate
and brain
and brain
study how
study
retroviruses
study
how retroviruses
how impact
retroviruses
impact
internal
impact
internal
organ
internal
organorgan
mechanisms
mechanisms
mechanisms
by which
by itwhich
operates.
by which
it operates.
Based
it operates.
on
BasedBased
on on
malformations.
malformations.
malformations.
His work
Hismay
work
Hislead
work
may
to lead
improved
maytolead
improved
to improved
failure failure
in burn
failure
invictims.
burn
in victims.
burn
His victims.
studies
His studies
may
His studies
justify
may justify
the
may justify
the the
their findings,
their findings,
their
they
findings,
will
they
design
will
theydesign
treatments
will design
treatments
treatmentsmethods
methods
for methods
genetic
for genetic
testing
for genetic
testing
of families
testing
of families
atofrisk
families
of
at riskatofrisk of
use of anti-retroviral
use ofuse
anti-retroviral
of anti-retroviral
drugs todrugs
improve
drugs
to improve
survival
to improve
survival
of survival
of of
to preserve
to preserve
these
to preserve
neurons.
these these
neurons.
neurons.
having having
children
having
children
withchildren
these
withdisorders.
these
with these
disorders.
disorders.
some children
some some
children
withchildren
severe
with severe
burns.
with severe
burns.burns.
Michelle
Michelle
James,
Michelle
James,
M.D.,
James,
is
M.D.,
developing
M.D.,
is developing
isnew
developing
tests
new tests
new
tests Chengji
Chengji
Zhou,
Chengji
Zhou,
Ph.D.,Zhou,
Ph.D.,
conducts
Ph.D.,
conducts
studies
conducts
studies
studies
Wenbin
Wenbin
Deng,
Wenbin
M.D.,
Deng,Deng,
Ph.D.,
M.D.,M.D.,
Ph.D.,
uses aPh.D.,
mouse
uses auses
mouse
model
a mouse
modelmodel
and new
and
procedures
new
andprocedures
newtoprocedures
enhance
to enhance
functional
to enhance
functional
functionalinvolving
involving
Wnt,
involving
a Wnt,
protein
Wnt,
a protein
thata controls
protein
that controls
that
developcontrols
developdevelopof cerebral
of cerebral
palsy
of cerebral
topalsy
test palsy
whether
to testtowhether
test
transplantation
whether
transplantation
transplantation
recovery
recovery
from
recovery
hand
frommalformations
hand
from malformations
hand malformations
and injuries.
and injuries.
and injuries.
ment ofment
limbs,
ment
of the
limbs,
of
face,
limbs,
theand
face,
the
theand
face,
brain.
the
andbrain.
Hethe brain.
He He
into theinto
brain
the
into
ofbrain
human
the brain
of human
skin-derived
of human
skin-derived
skin-derived
neural stem
neuralneural
stem stem
focusesfocuses
on Wnt
focuses
on
signaling
Wnt
onsignaling
Wnt
mutations
signaling
mutations
that
mutations
cause
that cause
that cause
cells orcells
treatment
or
cells
treatment
or
with
treatment
erythropoietin
with erythropoietin
with erythropoietin
(a drug(a drug
(a drug
Paul Knoepfler,
Paul Knoepfler,
Paul Ph.D.,
Knoepfler,
Ph.D.,
studies
Ph.D.,
studies
how studies
induced
how induced
how induced
spina bifida
spina and
spina
bifida
malformations
bifida
and malformations
and malformations
in facialinand
facial
in facial
and and
commonly
commonly
used
commonly
toused
treatto
used
anemia)
treat
to anemia)
treat
willanemia)
prevent
will prevent
will prevent
pluripotent
pluripotent
stem
pluripotent
cells
stem(iPSCs),
cells
stem (iPSCs),
cells
stem
(iPSCs),
cells
stem cells
stem cells
brain development.
brain brain
development.
development.
He alsoHe
investigates
also
Heinvestigates
also ways
investigates
inways ways
in in
neurological
neurological
neurological
deficits.deficits.
deficits.
prepared
prepared
from
prepared
the
from
skin,
the
from
can
skin,
the
be can
skin,
usedbeto
can
used
enhance
be to
used
enhance
to enhance
which Wnt-stimulated
whichwhich
Wnt-stimulated
Wnt-stimulated
spinal cord
spinal
scar
spinal
cord
formation
scar
cordformation
scar formation
the repair
the of
repair
the
many
repair
oforgans
many
of many
organs
with minimal
organs
with minimal
with
risk.minimal
risk. risk.
Diana Diana
Farmer,
Diana
Farmer,
M.D.,
Farmer,
is
M.D.,
a pediatric
M.D.,
is a pediatric
issurgeon
a pediatric
surgeon
surgeon
can be can
inhibited
becan
inhibited
be
to enhance
inhibited
to enhance
spinal
to enhance
cord
spinalspinal
cord cord
A potential
A potential
hazard
A potential
hazard
in using
hazard
inthese
using
incells
using
theseisthese
cells
that is
cells
thatis that
focusedfocused
on improving
focused
on improving
onsurgical
improving
surgical
methods
surgical
methods
andmethods
and and
regeneration.
regeneration.
regeneration.
they might
they give
might
theyrise
might
give
to tumors,
rise
givetorise
tumors,
and
to Dr.
tumors,
and
Knoepfler
Dr.
andKnoepfler
Dr. Knoepfler
2425 Stockton
24252425
Stockton
Boulevard
Stockton
Boulevard
Boulevard
Sacramento,
Sacramento,
Sacramento,
CA 95817
CA 95817
CA 95817
www.shrinershospitalsforchildren.org
www.shrinershospitalsforchildren.org
www.shrinershospitalsforchildren.org
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Driven
by
Driven
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by Excellence
by Excellence
in Treatment,
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Teaching
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Teaching
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