HOW TO MIX AND INSTILL HEXVIX®
The Hexvix® pack contains:
Other equipment you may need:
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85mg hexaminolevulinate (as
hexaminolevulinate hydrochloride), powder
in a sterile colorless glass vial
50ml polypropylene vial containing solvent
50ml Luer-Lok syringe
Large gauge needle (16 to 19G or 1.2 mm)
Luer-Lok adapter
1. Withdraw 50ml of the
Solvent for Hexvix® into a
sterile 50ml syringe. The
solvent is a clear, colorless
solution. It is recommended
to use a 16- or 19-gauge
needle (or 1.2mm).
2. Inject about 10ml of this
solvent into the vial of
Hexvix® powder. Without
withdrawing the needle
from the vial, hold the
powder vial and the syringe
in a firm grip and shake
gently to ensure complete
dissolution.
3. Withdraw all of the
dissolved solution from the
powder vial into the syringe.
Gently mix the contents of
the syringe.
4. Hexvix® is now
reconstituted and ready
for use. The appearance
of the reconstituted
solution is clear to slightly
opalescent, and colorless
to pale yellow.
5. Ensure that the bladder
is completely empty prior
to Hexvix® instillation.
Patients should be
catheterized. Connect
the syringe containing
Hexvix® to the catheter
using Luer-Lok and
gently instill 50ml of
Hexvix® into the bladder.
6. The patient should retain
the fluid for approximately
1h, and the cystoscopic
examination should start
no earlier than after 1h.
All steps should be performed with sterile equipment and under aseptic conditions.