Safely, Automatically and
Continuously Kill Harmful Bacteria
Don’t Just Clean... Indigo-Clean™
2
Your Partner in the Battle Against HAIs
Improved hand washing compliance and environmental hygiene are two
key initiatives to combat HAIs. Infection Preventionists and Environmental
Services have taken steps to monitor hand washing and establish room
cleaning protocols to reduce the transmission of harmful bacteria.
CAN WE DO MORE?
Page 3 ....................... What is Indigo-Clean?
Page 4 ....................... What Organisms is Indigo-Clean Effective Against?
Page 5 ....................... How Does It Work?
Page 6 ....................... Is Indigo-Clean Clinically Proven?
Page 7 ....................... Where Do I Use Indigo-Clean and Is It Safe?
10200 55th Street | Kenosha, Wisconsin 53144 | P: 1-262-891-9200 | E: [email protected] | www.indigo-clean.com
Indigo-Clean™ Safely, Automatically and Continuously Kill Harmful Bacteria
The Problem:
The Solution:
Current environmental disinfection methods are
applied at discrete moments in time (i.e. episodically).
The results of achieving a "clean room" are short-lived
as harmful bacteria re-populate the space.
Indigo-Clean™ offers a solution that continuously
disinfects the environment and bolsters your current
infection prevention efforts.
The environment is a reservoir for
pathogens. Indigo-Clean™ breaks the chain
of infection between the environment and
an unsuspecting host.
Mixed White LED Mode for when the room is occupied
Indigo-Clean™, a Continuous Environmental
Disinfection technology, uses visible light (not UV)
to safely, automatically and continuously kill harmful
bacteria, 24/7, in the air and on hard and soft
surfaces.
Don’t Just Clean... Indigo-Clean™
Indigo-Only LED Mode for maximum efficacy when room
is occupied or unoccupied.
What Makes Indigo-Clean Unique?
• Continuous environmental disinfection
• Indigo-Clean is NOT UV light... it uses 405nm visible light
• Automatically kills bacteria reducing risk of human error
• Kills bacteria in the air, and on hard and soft surfaces
• No special or additional training required
• Light is safe for patients and surfaces
• Product can be customized to balance cost, effectiveness
and visual preference for your application
Indigo-Clean™ is a light fixture that installs easily into the ceiling
providing excellent overhead lighting and continuous disinfection.
10200 55th Street | Kenosha, Wisconsin 53144 | P: 1-262-891-9200 | E: [email protected] | www.indigo-clean.com
3
4
Indigo-Clean™ Safely, Automatically and Continuously Kill Harmful Bacteria
Break the Chain of Infection by Raising Your Standard of Clean
Indigo-Clean™ bolsters current infection prevention methods and is proven to kill a wide range of harmful
bacteria including MRSA.
What does Indigo-Clean™ Kill?
Non-Exposed
Exposed
to Indigo-Clean™
ESKAPE Pathogens:
As well as a range of other organisms:
• Enterococcus faecalis
• Staphylococcal Aureus*
(including MRSA)1
• Klebsiella pneumoniae
• Acinetobacter baumannii
• Pseudomonas aeruginosa
• Enterobacter species
• Aspergillus niger
•E.coli
• Salmonella enteritidis
1
Maclean M., et. al. Environmental decontamination of a hospital isolation room using high-intensity narrow-spectrum light,
J. Hosp. Infection Vol. 76, pp. 247-251 (2010)
10200 55th Street | Kenosha, Wisconsin 53144 | P: 1-262-891-9200 | E: [email protected] | www.indigo-clean.com
5
Indigo-Clean™ Safely, Automatically and Continuously Kill Harmful Bacteria
How It Works:
Step 1: The 405nm emitted from Indigo-Clean reflects off of walls and surfaces, penetrating harmful micro-organisms
Step 2: The 405nm light targets and excites naturally occurring molecules within the bacteria called porphyrins, to produce intra-cellular Reactive Oxygen Species (ROS).
Step 3: Similar to bleach, these ROS creates an oxidative environment within the organism, inactivating it and preventing it from re-populating the space.
Creates ROS
405nm
Indigo-Clean™
Ultra Violet
(UV)
Oxygen
Superoxide anion
O2-
O2
H
Visible Light Safety Zone
Infrared
(IR)
H
H
Hydrogen Peroxide
Hydroxyl radical
H2O2
.OH
Peroxide
O2-2
H
Hydroxyl ion
OH-
+
400nm
500nm
600nm
700nm
405 nanometers: Peak germicidal activity via
photoexcitation of porphryin molecules
Bacteria Cell
Porphyrin
Inactivated
Bacteria Cell
Visible light spectrum showing the active element in Indigo-Clean™
Inactivation of bacteria via visable light absorption
10200 55th Street | Kenosha, Wisconsin 53144 | P: 1-262-891-9200 | E: [email protected] | www.indigo-clean.com
Indigo-Clean™ Safely, Automatically and Continuously Kill Harmful Bacteria
Continuously Reduce Overall Bioburden by 70%+ with Indigo-Clean™
Episodic
Systems
Visible
Light
Disinfection
Elapsed Time
Before
After
Least Square Means for CFU/plate
Whole-room Results
Killing Activity
6
90
82.7
80
71.2
70
70%
bacterial
60
50
40
31.5
reduction
30
20
10
0
Laboratory bacterial reduction after 24 hours
Clinical testing has shown Indigo-Clean can achieve
a continuous 70+ percent reduction of harmful
bacteria in the environment. At the same time, recently
published studies show that improved environmental
hygiene compliance can reduce HAI rates by up to
32% for certain organisms.1
Pre-
Visible
PostLight Disinfection
These results, combined with the additional cost per
patient due to HAI, suggest that preventing even a
single infection would create a positive ROI and drive
down costs for healthcare providers.
Indigo-Clean™ is currently being evaluated by several
institutions across the U.S. including Froedtert & the
Medical College of Wisconsin Froedtert Hospital in
Milwaukee, WI.
Recently completed studies at the Hospital involved
a 450 ft.2 waiting area in the Gastroenterology (GI)
Diagnostic clinic. This allowed the team to evaluate
the level of disinfection across a large, clinically relevant
area that was difficult to keep continuously clean due
to the large number of patients entering and exiting
over the course of the day. Over 2,000 samples were
collected during a period of 14 weeks at various times
of the day using multiple product configurations.
During this time, the use of the technology was
optimized for this room based upon its size, occupancy,
and visual preference of the patient/staff. The
results from this study showed a 70%+ continuous
reduction of S. aureus throughout the area and were
consistent with those from the University of Strathclyde
conducted at the Glasgow Royal Infirmary
(Glasgow, Scotland).2,3,4
Additional clinical partnerships with other hospitals
created through our Clinical Partners Program are
in process.
Indigo-only Solution (foreground), Mixed White Solution
(background); Waiting Room, Froedtert & the Medical
College of Wisconsin at Froedtert
1: Alfa MJ et. al. “Use of a daily disinfectant cleaner instead of a daily cleaner reduced hospital-acquired infection rates”, Am J Infect Control 2015;43:141-146
2: Maclean M., S.J. MacGregor, J.G. Anderson, G.A. Woolsey, J.E. Coia, K. Hamilton, I. Taggart, S.B. Watson, B. Thakker & G. Gettinby (2010). Environmental Decontamination of a Hospital Isolation Room using High-Intensity Narrow-Spectrum Light. Journal of Hospital Infection, 76(3); 247-251. DOI: 10.1016/j.jhin.2010.07.010
3: Bache S.E., M. Maclean, S.J. MacGregor, J.G. Anderson, G. Gettinby, J.E. Coia & I. Taggart (2012). Clinical studies of the High-Intensity Narrow-Spectrum light Environmental Decontamination System (HINS-light EDS), for continuous disinfection in the burn unit inpatient and outpatient settings. Burns, 38: 69-76. DOI:10.1016/j.burns.2011.03.008
4: Maclean M., M. Booth, S.J. MacGregor, J.G. Anderson, G.A. Woolsey, J.E. Coia, K. Hamilton & G. Gettinby (2013). Continuous decontamination of an intensive care isolation room during patient occupancy using 405nm light technology. Journal of Infection Prevention, 14(5); 176-181. DOI:
10200 55th Street | Kenosha, Wisconsin 53144 | P: 1-262-891-9200 | E: [email protected] | www.indigo-clean.com
7
Indigo-Clean™ Safely, Automatically and Continuously Kill Harmful Bacteria
Product
When to use it
Applications
Switchable
When flexibility between visual acuity,
comfort and disinfection is required.
• Operating Room
A solution where you can conveniently
toggle between mixed white or Indigoonly, depending on room usage patterns
or personal preference.
• Pharmacy
A solution which emits the highest
dosage of bacteria killing light (exclusively 405nm).
• Medical Equipment Strorage Areas
Safe to use when room is occupied or
unoccupied.
• Any room in"after-hours mode"
Best suited for times when comfort and
visual acuity are critical.
Anywhere, but particularly
effective in:
• Sterile Processing
• Procedure Room
• Recovery Room
Switchable Incorporates Two Modes:
Indigo-Only Mode
Mixed White Mode
• Patient Bathroom
• Janitor Closets
• Operating Room
• Sterile Processing
A solution combining Indigo (405nm) and
• Pharmacy
standard white LEDs to reate the look of
white overhead lighting. Use when room • Procedure Room
• Recovery Room
is occupied.
• Waiting Areas
Safety Evaluation
1.00
0.020
0.90
0.018
0.80
0.016
0.70
0.014
0.60
0.012
0.50
0.010
0.40
0.008
0.30
0.006
0.20
0.004
0.10
0.002
.00
0.000
360
410
460
510
560
610
660
710
Wavelength (nm)
Source
Blue Light Hazard Function, B( )
Visual Efficiency Function, V( )
D65 Daylight Spectrum CCT=6500K
Circadian Response, C( )
760
Visible light disinfection has been evaluated against
existing safety standards.
Irradiance (W/m 2)
Relative Weight of Efficiency Functions
Relative Influence on Wavelength on Visual Hazard
Standard
Testing Method
Results
IEC 62471/627781,2
Independent 3rd Party Laboratory
Pass (Exempt)
ACGIH3
Self-Assesment
Pass
ICNIRP4,5
Self-Assesment
Pass
1: International Electrotechnical Commission – Photobiological safety of lamps and lamp systems, 2006
2: International Electrotechnical Commission – Application of IEC 62471 for the assessment of blue light hazard to light sources and luminaires, 2014
3: American Conference of Governmental Industrial Hygienists – Threshold Limit Values (TLVs) & Biological Exposure Indicies Signature Publications, Cincinnati, 2007
4: International Commission on Non-Ionizing Radiation Protection – Guidelines on limits of exposure to optical radiation from 0.38 to 3.9 mm. Health Physics 73; 539-555; 1997
5: International Commission on Non-Ionizing Radiation Protection – Guidelines on limits of exposure to ultraviolet radiation of wavelengths between 180 nm and 400 nm (incoherent radiation) Health Physics 87, 171-186; 2004
10200 55th Street | Kenosha, Wisconsin 53144 | P: 1-262-891-9200 | E: [email protected] | www.indigo-clean.com
8
Indigo-Clean™ Safely, Automatically and Continuously Kill Harmful Bacteria
Don’t Just Clean... Indigo-Clean™
10200 55th St.
Kenosha, Wisconsin 53144
P: 1-262-891-9200
E: [email protected]
www.indigo-clean.com
©2016 Kenall Mfg. Co.
All rights reserved.
¯¯
@GetIndigoClean