Table S1. The Main and Interaction Effects on ANS of Group (Control, Remitted MDD and Current MDD) and Condition (N-back Rest and N-back Task)
Group effect
a
Condition effect
Remitted MDD
Current MDD
vs. control
vs. control
Variable
a
N-back task vs. n-back rest
Group*condition effect
a
Remitted MDD
Current MDD
*n-back task
*n-back task
Estimate
p-value
Estimate
p-value
Estimate
p-value
Estimate
p-value
Estimate
p-value
Unadjusted
-1.47
.010
-1.80
.007
3.50
<.001
-0.75
<.001
-0.84
.001
c
-2.00
<.001
-2.36
<.001
3.50
<.001
-0.75
<.001
-0.84
.001
d
-2.20
<.001
-2.90
<.001
3.50
<.001
-0.75
<.001
-0.84
.001
Unadjusted
-0.02
.59
-0.04
.29
-0.11
<.001
0.03
.10
0.07
.003
c
0.01
.87
-0.02
.63
-0.11
<.001
0.03
.10
0.07
.003
d
0.06
.057
0.07
.053
-0.11
<.001
0.03
.10
0.07
.003
Unadjusted
-0.05
.14
-0.09
.021
-0.14
<.001
0.02
.26
0.05
.011
c
-0.03
.34
-0.07
.028
-0.14
<.001
0.02
.26
0.05
.011
d
0.03
.27
0.02
.47
-0.14
<.001
0.02
.26
0.05
.011
Unadjusted
-1.91
.071
-0.72
.56
-2.48
<.001
0.33
.29
0.75
.035
c
-1.70
.10
-0.59
.63
-2.48
<.001
0.33
.29
0.75
.035
d
-1.99
.053
-0.37
.76
-2.48
<.001
0.33
.29
0.75
.035
HR (beats/min)
Adjusted
Adjusted
RMSSD (ms)
Adjusted
Adjusted
RSA (ms)
b
b
Adjusted
Adjusted
PEP (ms)
Adjusted
Adjusted
Note: MDD = major depressive disorder. HR = heart rate. RMSSD = root mean square of successive differences. RSA = respiratory sinus arrhythmia. PEP = pre-ejection period.
a
b
c
Main effects of group and condition were analyzed in a mixed model separate from the interaction effect of group*condition.
Values were ln-transformed for analyses.
Adjusted for respiration rate, age, sex, education, BMI, physical activity, smoking, alcohol use, heart disease, chronic disease, heart medication and n-back task performance.
d
c
Adjustment + additionally adjusted for antidepressant use.
Table S2. The Main and Interaction Effects on ANS of Group (Control, Remitted MDD and Current MDD) and Condition (General Interview and Psychiatric Interview)
Group effect
a
Condition effect
a
Group*condition effect
a
Remitted MDD
Current MDD
Psychiatric interview vs.
Remitted MDD
Current MDD
vs. control
vs. control
general interview
*psychiatric interview
*psychiatric interview
Variable
Estimate
p-value
Estimate
p-value
Estimate
p-value
Estimate
p-value
Estimate
p-value
Unadjusted
-0.74
.18
-0.97
.13
3.50
<.001
0.98
<.001
1.21
<.001
c
-1.16
.030
-1.51
.015
3.50
<.001
0.98
<.001
1.21
<.001
d
-1.46
.006
-2.26
<.001
3.50
<.001
0.98
<.001
1.21
<.001
Unadjusted
-0.05
.13
-0.06
.086
-0.14
<.001
-0.03
.036
-0.06
<.001
c
-0.03
.35
-0.03
.33
-0.14
<.001
-0.03
.036
-0.06
<.001
d
0.01
.63
0.04
.27
-0.14
<.001
-0.03
.036
-0.06
<.001
Unadjusted
-0.04
.18
-0.07
.038
-0.11
<.001
-0.02
.044
-0.03
.004
c
-0.02
.35
-0.05
.11
-0.11
<.001
-0.02
.044
-0.03
.004
d
0.03
.27
0.04
.16
-0.11
<.001
-0.02
.044
-0.03
.004
Unadjusted
-1.74
.077
-1.02
.37
-2.27
<.001
-0.21
.55
-0.21
.60
c
-1.71
.083
-1.14
.32
-2.27
<.001
-0.21
.55
-0.21
.60
d
-2.15
.026
-1.01
.38
-2.27
<.001
-0.21
.55
-0.21
.60
HR (beats/min)
Adjusted
Adjusted
RMSSD (ms)
Adjusted
Adjusted
RSA (ms)
b
b
Adjusted
Adjusted
PEP (ms)
Adjusted
Adjusted
Note: MDD = major depressive disorder. HR = heart rate. RMSSD = root mean square of successive differences. RSA = respiratory sinus arrhythmia. PEP = pre-ejection period.
a
b
c
Main effects of group and condition were analyzed in a mixed model separate from the interaction effect of group*condition.
Values were ln-transformed for analyses.
Adjusted for respiration rate, age, sex, education, BMI, physical activity, smoking, alcohol use, heart disease, chronic disease and heart medication.
d
c
Adjustment + additionally adjusted for antidepressant use.
Table S3. The Main and Interaction Effects on ANS of Group (Control, Remitted Anxiety and Current Anxiety) and Condition (N-back Rest and N-back Task)
Group effect
a
Condition effect
Remitted Anxiety
Current Anxiety
vs. control
vs. control
Variable
a
N-back task vs. n-back rest
Group*condition effect
a
Remitted Anxiety
Current Anxiety
*n-back task
*n-back task
Estimate
p-value
Estimate
p-value
Estimate
p-value
Estimate
p-value
Estimate
p-value
Unadjusted
-1.69
.005
-1.97
.002
3.47
<.001
-0.68
.002
-1.03
<.001
c
-2.05
<.001
-2.51
<.001
3.47
<.001
-0.68
.002
-1.03
<.001
d
-2.31
<.001
-2.85
<.001
3.47
<.001
-0.68
.002
-1.03
<.001
-0.001
.98
-0.05
.23
-0.11
<.001
0.04
.071
0.06
.010
c
0.02
.62
-0.03
.42
-0.11
<.001
0.04
.071
0.06
.010
d
0.08
.016
0.05
.16
-0.11
<.001
0.04
.071
0.06
.010
Unadjusted
-0.04
.25
-0.07
.068
-0.14
<.001
0.03
.099
0.03
.097
c
-0.03
.25
-0.06
.042
-0.14
<.001
0.03
.099
0.03
.097
d
0.03
.24
0.02
.51
-0.14
<.001
0.03
.099
0.03
.097
Unadjusted
-1.95
.076
-0.10
.93
-2.54
<.001
0.41
.21
0.37
.28
c
-1.67
.12
0.28
.81
-2.54
<.001
0.41
.21
0.37
.28
d
-1.64
.12
0.25
.83
-2.54
<.001
0.41
.21
0.37
.28
HR (beats/min)
Adjusted
Adjusted
RMSSD (ms)
Unadjusted
Adjusted
Adjusted
RSA (ms)
b
b
Adjusted
Adjusted
PEP (ms)
Adjusted
Adjusted
Note: HR = heart rate. RMSSD = root mean square of successive differences. RSA = respiratory sinus arrhythmia. PEP = pre-ejection period.
a
b
c
Main effects of group and condition were analyzed in a mixed model separate from the interaction effect of group*condition.
Values were ln-transformed for analyses.
Adjusted for respiration rate, age, sex, education, BMI, physical activity, smoking, alcohol use, heart disease, chronic disease, heart medication and n-back task performance.
d
c
Adjustment + additionally adjusted for antidepressant use.
Table S4. The Main and Interaction Effects on ANS of Group (Control, Remitted Anxiety and Current Anxiety) and Condition (General Interview and Psychiatric Interview)
Group effect
a
Condition effect
a
Group*condition effect
a
Remitted Anxiety
Current Anxiety
Psychiatric interview vs.
Remitted Anxiety
Current Anxiety
vs. control
vs. control
general interview
*psychiatric interview
*psychiatric interview
Variable
Estimate
p-value
Estimate
p-value
Estimate
p-value
Estimate
p-value
Estimate
p-value
Unadjusted
-0.97
.10
-1.29
.037
3.50
<.001
0.87
<.001
1.35
<.001
c
-1.24
.030
-1.81
.003
3.50
<.001
0.87
<.001
1.35
<.001
d
-1.68
.003
-2.37
<.001
3.50
<.001
0.87
<.001
1.35
<.001
Unadjusted
-0.04
.30
-0.04
.26
-0.14
<.001
-0.03
.027
-0.05
.001
c
-0.02
.60
-0.01
.67
-0.14
<.001
-0.03
.027
-0.05
.001
d
0.03
.30
0.05
.17
-0.14
<.001
-0.03
.027
-0.05
.001
Unadjusted
-0.03
.35
-0.06
.082
-0.11
<.001
-0.02
.14
-0.03
.008
c
-0.02
.47
-0.04
.13
-0.11
<.001
-0.02
.14
-0.03
.008
d
0.04
.13
0.03
.28
-0.11
<.001
-0.02
.14
-0.03
.008
Unadjusted
-1.94
.058
-0.58
.59
-2.23
<.001
-0.23
.53
-0.08
.84
c
-1.85
.069
-0.36
.74
-2.23
<.001
-0.23
.53
-0.08
.84
d
-2.06
.039
-0.60
.58
-2.23
<.001
-0.23
.53
-0.08
.84
HR (beats/min)
Adjusted
Adjusted
RMSSD (ms)
Adjusted
Adjusted
RSA (ms)
b
b
Adjusted
Adjusted
PEP (ms)
Adjusted
Adjusted
Note: HR = heart rate. RMSSD = root mean square of successive differences. RSA = respiratory sinus arrhythmia. PEP = pre-ejection period.
a
b
c
Values were ln-transformed for analyses.
Adjusted for respiration rate, age, sex, education, BMI, physical activity, smoking, alcohol use, heart disease, chronic disease and heart medication.
d
Main effects of group and condition were analyzed in a mixed model separate from the interaction effect of group*condition.
c
Adjustment + additionally adjusted for antidepressant use.