27th Interdisciplinary
Research Conference
on Injectable Biomaterials
and Interventional Procedures
Presidents
A. D. Kelekis
P. J. Papagelopoulos
E. P. Efstathopoulos
Athens
18-21 May 2017
Divani Apollon Palace
www.griboi2017.com
email: [email protected]
www.griboi.org
Congress Secretariat:
4, Eleftheroton Square • 15232 Halandri - Athens, Greece
Phone: +30 210 6852892 • Fax: +30 210 6846676
email: [email protected] • [email protected]
www.theotokistravel.gr
SCIENTIFIC PROGRAM
GRIBOI 2017
27th Interdisciplinary Research Conference
on Injectable Biomaterials
and Interventional Procedures
Athens, 18-21 May 2017
20 CME-CPD Credits
Conference Venue:
Divani Apollon Palace & Thalasso
10, Ag. Nikolaou & Iliou Str.
166 71 Vouliagmeni - Athens
Tel.: 00302108911100
GRIBOI 2017 Secretariat:
Theotokis Travel Congresses
Lufthansa City Center
4, Eleftheroton Sq., 15232 Halandri, GR
Tel: +30 210 6852892
Fax: +30 210 6846676
[email protected]
www.griboi2017.com
Welcome
The GRIBOI association stands for “Groupe de Recherche Interdisciplinaire sur les
Biomatériaux Ostéoarticulaires Injectables”, and was first founded and led by Dr.
Hervé Deramond, pioneer and founder of vertebroplasty.
For many years the GRIBOI association, under M. Bohner’ s successful presidency,
has been bringing together the Basic Sciences in Chemistry, Bioengineering and
Biocompatibility, in collaboration with Medical Doctors from Interventional
Radiology, Neurosurgeons and Orthopedics, allowing us as a group to step into the
future of new biocompatible devices and materials for percutaneous interventions.
Our 2017 meeting, in partnership with the “Hellenic Society of Nanotechnology in
Health Sciences”, aims upon three major pillars: Interdisciplinary Collaboration,
Image Guided Therapy and Injectable Materials.
This year’s meeting, taking place in Athens, Greece from 18-21 May 2017, will offer
unparalleled opportunities for networking with colleagues and luminaries from
around the globe. Consultants and young scientists together with industry in a
common ground on Percutaneous Image Guided Therapies, will have the chance to
explore a new world with ground breaking science.
On behalf of the GRIBOI organization, volunteers and staff, we wish you an
extraordinary, memorable and productive stay here in Athens, Greece.
th
The Presidents of the 27 GRIBOI Meeting
A. D. Kelekis MD, PhD
Ass. Prof. of Interv. Radiology
University of Athens
President of the GRIBOI Society
P. J. Papagelopoulos, MD
Professor & Chairman
First Department of Orthopedics
Athens University Medical School
& Attikon University General Hospital,
Athens Greece
E. P. Efstathopoulos PhD
Prof. of Medical Physics
University of Athens
President of the Hellenic Society
of Nanotechnology in Health Sciences
LOCAL ORGANIZING COMMITTEE
A. Kelekis (PRESIDENT)
P. Papagelopoulos (PRESIDENT)
E. Efstathopoulos (PRESIDENT)
D. Filippiadis (SCIENTIFIC PROGRAM DIRECTOR)
HONORARY COMMITTTEE
M. Argyropoulou
D. Kelekis
G. Babis
N. Kelekis
E. Brountzos
E. Moulopoulou
A. Charitanti-Kouridou
Th. Petsas
A. Chatziioannou
S. Pnevmatikos
I. Fezoulidis
P. Prasopoulos
A. Karantanas
D. Siablis
GRIBOI Scientific Committee
Stephan
Becker
Austria
Alan
Brook
USA
Hervé
Deramond
France
Dimitrios
Filippiadis
Greece
Bassem
Georgy
USA
Scott
Guelcher
USA
Wouter
Habraken
Germany
Joshua
Hirsch
USA
Pascal
Janvier
France
Joseph
Lane
USA
Michael
Liebschner
USA
William
Lu
H.K./China
Peter
Munk
Canada
Kieran
Murphy
Canada
Malin
Nilsson
Spain
Sean
Tutton
USA
Pierre
Weiss
France
THURSDAY, 18 May 2017
17:00-17:30
Registration
17:30-19:10
Session 1 SPINE I
Moderators: J. Hirsch, P. Papagelopoulos
1. K. Stathopoulos: Ageing and Bone Strength-what we know is what we measure
2. D. Beal:
The Use of Mesenchymal Stem Cells in Patients with Degenerative Disc
Disease and Discogenic Backpain
3. S. Becker:
New insights into cell / biomaterial based disc therapies
4. S. Marcia:
The use of percutaneous interspinous spacers in spinal canal stenosis
treatment: pros and cons.
5. B. Georgy:
New tools and devices for Vertebral augmentation
19:10 OPENING CEREMONY
HIGHLIGHT LECTURE
Moderators: A. Kelekis, P. Papagelopoulos, E.P. Efstathopoulos
K. Murphy: Why do we believe what we believe in techno anthropology and industry
OPENING RECEPTION
END OF DAY 1
1
FRIDAY, 19 May 2017
08:30-10:00
Session 2 NEW MATERIAL AND DEVELOPMENT
Moderators: C. Combes, M. Bohner
6. S. Willis:
Innovation and product development process
7. A. Cholakis-Kelekis: A review of materials used in periodontal / osseous regeneration
8. N. Mattheos:
Guided Bone Regeneration: challenges and opportunities
in the dentoalveolar region
9. S. Becker:
Nano filtration of cells for biological resorbable implants
10:00-10:30
10:30-12:30
Morning break - Sponsor and Exhibitor Viewing
Session 3 IMAGING/NANOTECHNOLOGY
Moderators: J. Hirsch, N. Uzunoglu
10. M. Lykissas: Minimal spine fixation techniques, using Intra Operative Navigation
11. A. Michos:
Ultrasound/CT-MR FUSION and virtual needle guide navigation
12. G. Loundos: Multimodal imaging as a tool to non invassively assess bone
regeneration: The VIVOIMAG project
13. S. Wetzel:
Navigation in image guided interventions
14. M. Rouchota: Assessment of low energy X-rays for high density
nanoparticles imaging
15. Α. Plousi:
e-learning of National and Kapodistrian University of Athens
(NKUA). Nanotechnology and Nanomedicine Programmes
12:30-13:30
Lunch break
2
FRIDAY, 19 May 2017
13:30-15:00
KEYNOTE LECTURE AND ABSTRACTS
Moderators: S. Tutton, K. Murphy
K. Murphy: Radiation management and premedication for the professional
1. Backpropagation neural network-based fast CT imaging screening recognized and predicted trabecular bone microdamage in
osteoporotic lumbar vertebrae: a pilot study
1
1
1
1
Chentian Li , Lei Xu , Wing Yuk Ip , William W. Lu
1
Department of Orthopedics & Traumatology, The University of Hong Kong, Hong Kong, China
2. Modifying ready-to-use injectable calcium phosphate bone cements for in-situ pore formation and protein delivery
applications
1
2
2
1
M Schumacher , S Rößler , T Hanke , A Lode1, M Gelinsky
1
Centre for Translational Bone-, Joint- and Soft Tissue Research, Technische Universität Dresden, Dresden, Germany
Max Bergmann Center of Biomaterials and Institute for Materials Science, Technische Universität Dresden,
Dresden, Germany
2
3. Biomechanical analysis by finite element method of cement effects for stabilisation of tibial plateau split depression fracture
1,2
2,3,5
2
1
2
2,4
2
D Belaid , T Vendeuvre , A. Germaneau , A. Bouchoucha , F. Brémand , C. Brèque , P. Rigoard ,
1
Université des Frères Mentouri, Constantine, Algery. 2 Institut Pprime UPR 3346, CNRS – Université de Poitiers –
ISAE-ENSMA, France. 3 Department of Orthopaedic Surgery and Traumatology, CHU, Poitiers France. 4 Laboratory of
Anatomy, Université de Poitiers, France. 5 Department of Neurosurgery, Prismatics Lab, CHU, Poitiers, France.
4. Kyphoplasty vs Stentoplasty: influence on the fracture reduction and on the risk of cement leakage
1,2
1
1
2
1
1
2,3
1
T Vendeuvre , P. Brossard , JB Pic , A Germaneau , LE Gayet , P Pries , P Rigoard , S Teyssédou
1
Department of Orthopaedic Surgery and Traumatology, CHU, Poitiers France. 2 Institut Pprime UPR 3346, CNRS –
Université de Poitiers – ISAE-ENSMA, France. 3 Department of Neurosurgery, Prismatics Lab, CHU, Poitiers, France.
5. Minimally Invasive Palliative Procedures in Oncology and Haematology: a retrospective review of 12 months
practice in New Zealand
1-5
4
4
4
4
4
Colin CW Chong , Rachel Wiseman , Kate Grundy , Brendon Anderson , Ruth Spearing , Andrew Butler , et al.
1.
3.
4.
I-Med Radiology Network, Queensland, Australia. 2. Wesley Hospital, Brisbane, Queensland, Australia.
St. Andrew’s War Memorial Hospital, Brisbane, Queensland, Australia.
Canterbury Regional Cancer and Haematology Service, Canterbury District Health Board, Christchurch, New Zealand.
Mercy Hospital, Auckland, New Zealand
6. Effect of blood proteins on the strength, setting time and relative porosity of novel Portland cement for vertebroplasty
1
1
1
A Moetazedian , MP Hofmann , RM Shelton
1
Biomaterial unit, School of Dentistry, University of Birmingham, United Kingdom
7. Smart hydrogels for delivery of drug agents against pancreatic cancer
1
1
D Skoulas , H Iatrou
1
Laboratory of Industrial Chemistry, Chemistry Department, University of Athens, Greece.
8. The placebo effect of the guided PRP injections in patients with lateral epicondylitis: a double-blinded randomized controlled
clinical trial
12
1
1
1
1
1
M-A Malahias , M-K Kaseta , E Chronopoulos , V S. Nikolaou , A P. Efstathiou , G C. Babis
1
2nd Orthopaedic Department, National and Kapodistrian University of Athens Medical School, Athens, Greece
International Centre for Hip, Knee and Foot Surgery, Sport Traumatology, ATOS Klinik, Heidelberg, Germany
2
3
FRIDAY, 19 May 2017
15:00-16:30
Session 4 MSK ABLATION
Moderators: A. Mavrogenis, D. Koulalis
16. W. Lea :
17. D.K. Filippiadis:
18. S. Masala:
19. P. Maniatis:
16:30-17:00
17:00-18:45
Combined treatments: Ablation and Screw fixation
Osteoarthritis of the knee joint: Current local therapies
Ablation for benign bone tumors
Software for ablation: Current concepts and future trends
Afternoon break - Sponsor and Exhibitor Viewing
Session 5 NEW BIOMATERIAL DEVELOPMENT
AND TECHNOLOGY
Moderators: J-M. Bouler, A. Chatziioannou
20. M. Bohner: What is the minimum pore size for bone ingrowth?
21. Ε. Douni:
Biological properties of Phosphate-Hydroxyapatite Cements
22. P. Papagelopoulos: 3D printed implants for bone reconstruction: Clinical applications
23. C. Combes: Injectable and resorbable composite bone cement with sustained antibacterial
activity
24. A. Brook:
New glass based injectable agent and other future agents
END OF DAY 2
4
SATURDAY, 20 May 2017
08:30-10:00
Session 6 ONCOLOGY
Moderators: D.K. Filippiadis, S. Masala
25. P. Papagelopoulos: Silver coated mega-prostheses in orthopaedic oncology
26. O. Andreani:
Augmented osteoplasty in the hip
27. E. Papadopoulos: Metastatic spine disease: Is there a place for kyphoplasty
28. A. Kelekis:
The rebar concept
10:00-10:30
10:30-12:15
Morning break - Sponsor and Exhibitor Viewing
Session 7 ABLATION OUTSIDE MSK
Moderators: E. Brountzos, N. Kelekis
29. D.K. Filippiadis: MWA in kidney
30. A. Michos:
IRE
31. B. Kastler:
Migraine therapy
32. M. Tsitskari:
Cryoablation
33. N. Ptohis:
Neurolysis for cancer pain management
12:15 - 12:50
General Assembly
12:50-13:30
Lunch break
13:30-15:00
Session 8 NEW BIOMATERIAL DEVELOPMENT AND
TECHNOLOGY
Moderators: E.P. Efstathopoulos, I. Sokolov
34. I. Sokolov:
35. J-M. Bouler:
36. O. Savvidou:
37. S. Papadakis:
Ultrabright fluorescent particles to study cancerous cells
Potential anti-cancer activity of drug-combined biomaterials
Applications of nanotechnology in Orthopaedics
Biomechanics: Bone cement
5
SATURDAY, 20 May 2017
15:00-16:30
KEYNOTE LECTURE AND ABSTRACTS
Moderators: A. Kelekis, F. Facchini
F. Facchini: Multiple Hats over one Head: How to be a successful practicing physician, corporate
executive and consultant
09. EVOLVE: A prospective and multicenter evaluation of outcomes for quality of life, pain and activities of daily living for
balloon kyphoplasty in the treatment of medicare-eligible subjects with vertebral compression fractures
1
2
3
4
5
6
7
8
9
DP Beall, MR Chambers, SM Thomas, R Easton, S Talati, B Goodman, D Datta, JR Webb, D Linville
1
Clinical Radiology of Oklahoma, Oklahoma city, OK 2 University of Alabama at Birmingham, Birmingham, AL, USA., 3Allegheny University,
Meadville, PA, USA. 4 Beaumont Health System, Troy, MI, USA. 5 Advanced Diagnostic Imaging, PC, Saginaw, MI, USA. 6 Alabama Ortho Spine
and Sports, Birmingham, AL, USA. 7The Back Center, Melbourne, FL, USA. 8The Osteoporosis Center, Tulsa, OK, USA. 9 Scoliosis & Spine Surgery
Clinic of Memphis, PLLC, Memphis, TN, USA
10. Analgesic drug release from CPCs: first in vivo study using CatWalk system
1
2,3
2
2
1
1
M Dupleichs , O Gauthier , M Masson , E Verron , J M Bouler , P Janvier
1
CEISAM, UMR CNRS 6230, Nantes University, France. 2LIOAD, INSERM U791, Nantes University, France. 3ONIRIS College of Veterinary Medicine,
Nantes, France
11. Radiofrequency Ablation of Kidney Tumors with High Frequency Jet Ventilation and Real Time US-CT Image Fusion/Virtual
Needle-Track Guiding. A Single Center Experience.
A. Michos1, V. Grozman1, T. Josephson2
1Karolinska University Hospital, Karolinska Institute ,Stockholm-Sweden/SE 2Danderyd Hospital, Karolinska Institute, Stockholm-Sweden/SE,
12. Irreversible Electroporation of Liver Tumors with High Frequency Jet Ventilation and Real Time US-CT Image Fusion/Virtual
Needle-Track Guiding. A Single Center Experience.
A. Michos1,V. Grozman1, T. Josephson2;
1 Karolinska Hospital, Karolinska Institute ,Stockholm - Sweden/SE 2Danderyd Hospital, Karolinska Institute, Stockholm - Sweden/SE
13. Microwave Ablation of Liver Tumors with Real Time US-CT/MRI Image Fusion/Virtual Needle-Track Guiding. A Single Center
Experience.
A. Michos1, V. Grozman1, T. Josephson2;
1Karolinska Hospital, Karolinska Institute ,Stockholm-Sweden/SE 2Danderyd Hospital, Karolinska Institute, Stockholm-Sweden/SE,
14. Efficacy of a vertebral augmentation system used for bone remodelling as treatment of vertebral fractures
1
1
1
1
2
S Marcia , E Piras , A Spinelli , S Marini , L Saba
1
Department of Radiology, PO SS Trinità, Cagliari, IT , 2 Department of Radiology, University of Cagliari, Cagliari, IT
15. Novel hydrogel is effective in restoring the mechanical property of osteoporotic bone with hole defects
1
1
1
Lei Xu , Chen-Tian Li , F.K.L. Leung, W.W. Lu
1
Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR, China
6
SATURDAY, 20 May 2017
16:30-17:00
17:00-19:00
Afternoon break - Sponsor and Exhibitor Viewing
Session 9 SPINE II
Moderators: S. Marcia, G. Athanasiou
38. J.B. Martin:
39. M. Nilsson:
40. D. Beal:
41. J. Hirsch:
42. L. Manfre:
43. B. Georgy:
Percutaneous disc treatments: Thermal, Mechanical and Chemical
Modified PMMA for osteoporotic vertebral fracture - reason for a better
suited PMMA cement for fragile bone
The Results of a Large Kyphoplasty Trial in Typical Patients with
Vertebral Compression Fractures: An As-Treated, On-Label Trial
Augmentation update from ASSR
Percutaneous fixation of the spine in spinal instability: what’s new about
Radiofrequency ablation of Spine tumors, past present and future
END OF DAY 3
7
SUNDAY, 21 May 2017
09:00-10:30
.
Session 10 NEW BIOMATERIAL DEVELOPMENT AND
TECHNOLOGY
Moderators: A. Brook, L. Manfre
44. J. Papanastasiou: Extracortical bridging using HA in megaprosthesis
45. M. Nilsson:
Bioresorbable cements, antibiotics and bone remodeling
46. V. Sakellariou: Tantalum implants for complex bone defects
47. W. Lu:
A novel prevention treatment Injectable Biomaterials
for osteotrabeculoplasty
10:30-11:00
11:00-12:00
Morning break - Sponsor and Exhibitor Viewing
ABSTRACTS
16. A single ultrasound-guided PRP (platelet-rich plasma) infiltration in chronic plantar fasciitis: a double-blinded randomized
comparative clinical study
12
1
1
1
1
1
M-A Malahias , M-K Kaseta , E Chronopoulos , V S. Nikolaou , A P. Efstathiou , G C. Babis
1
2nd Orthopaedic Department, National and Kapodistrian University of Athens Medical School, Athens, Greece
International Centre for Hip, Knee and Foot Surgery, Sport Traumatology, ATOS Klinik, Heidelberg, Germany
2
17. Differential effect of subcytotoxic exposure of folic acid functionalized nanoparticles on migration of
normal kidney and cancerous breast cells
1
1
1
E Flampouri , D Theodosi-Palimeri , S Kintzios
1
Laboratory of Cell Technology, Department of Biotechnology, School of Food, Biotechnology and Development (TBA),
Agricultural University of Athens, Greece.
18. Bioactivity and effect of hyperbranched poly(ethyleneimine)-based nanoparticles on plant pathogenic fungi
1
1
2
2
1
M Lykogianni , EA Papadopoulou , Z Sideratou , D Tsiourvas , KA Aliferis
1
2
Laboratory of Pesticide Science, Agricultural University of Athens, Greece.
Institute of Nanoscience and Nanotechnology, NCSR Demokritos, Athens, Greece.
19. Morphology and biophysical properties of pH-responsive nanotechnological chimeric/mixed liposomal platforms as
innovative drug delivery systems
1
1,2
2
2
1,
3
3
N Naziris , N Pippa , V Chrysostomou , S Pispas , C Demetzos *, M Libera , B Trzebicka
1
Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Greece.
Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, Greece.
3
Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Poland
2
20. Randomized evaluation of bone ingrowth after Anterior Lumbar Interbody Fusion (ALIF) with a new osteoinductive bone
graft material (NanoBone / putty)
I Papachristos, M Rickert, M Rauschmann
Orthopaedic University Hospital Friedrichsheim in Frankfurt am Main, Germany
21. Temperature-sensitization of HSPC liposomes by use of thermosensitive homopolymer PNIPAM
1
1
2
2
1,
A Tzani , N Naziris , A Meristoudi , S Pispas , C Demetzos *
1
Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Greece.
Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, Greece.
2
22. Surface functionalization of titanium with strontium-substituted hydroxyapatite and miR-21 Nanocapsules to Enhance Bone
Regeneration
Zhen Geng, Zhenduo Cui, Zhaoyang Li, Xubo Yuan, Shengli Zhu, Yanqin Liang, Xianjin Yang
School of Materials Science and Engineering, Tianjin University, China.
23. Long-term drug delivery depots formed by isostatic pressing
1
2
2
1
S Grudén , H Lennernäs , G Alderborn , N Axén
1
LIDDS AB, Virdings allé 32b, SE-754 50 Uppsala, Sweden. 2 Uppsala University, Department of Pharmacy, Box 580, SE-751 23 Uppsala, Sweden
8
SUNDAY, 21 May 2017
12:00-14:30
Session 11 PERIPHERAL SKELETON
Moderators: A. Kelekis, P. Papagelopoulos
48. D.K. Filippiadis: Ablation in the peripheral skeleton
49. O. Andreani:
Percutaneous stabilization in peripheral skeleton
50. S. Tutton:
MRgFUS and other ablations and their effect on bone strength and healing
51. M. Kaseta:
PRP and Stem Cells for articulations: Where do we stand
52. A. Mavrogenis: Minimally invasive techniques in Orthopaedic oncology
53. P. Diamantopoulos: 3D printing technology in Medicine: where do we stand
END OF DAY 4
9
FACULTY:
Andreani
Athanasiou
Beal
Becker
Bohner
Bouler
Brook
Brountzos
Chatziioannou
Cholakis-Kelekis
Combes
Diamantopoulos
Douni
Efstathopoulos
Facchini
Filippiadis
Georgy
Hirsch
Kaseta
Kastler
Kelekis
Kelekis
Koulalis
Lea
Loundos
Lu
Lykissas
O. (FR)
G. (GR)
D. (USA)
S. (AU)
M. (CH)
J-M. (FR)
A. (USA)
E. (GR)
A. (GR)
A. (CA)
C. (FR)
P. (GR)
E. (GR)
E.P. (GR)
F. (USA)
D K. (GR)
B. (USA)
J. (USA)
M. (GR)
B. (FR)
A. (GR)
N. (GR)
D. (GR)
W. (USA)
G. (GR)
W. (HK)
M. (GR)
Manfre
Maniatis
Marcia
Martin
Masala
Mattheos
Mavrogenis
Michos
Murphy
Nilsson
Papadakis
Papadopoulos
Papagelopoulos
Papanastasiou
Plousi
Ptohis
Rouchota
Sakellariou
Savvidou
Sokolov
Stathopoulos
Tsitskari
Tutton
Uzunoglu
Wetzel
Willis
L. (IT)
P. (GR)
S. (IT)
J B. (CH)
S. (IT)
N. (HK)
A. (GR)
A. (SWE)
K. (CA)
M. (SWE)
S. (GR)
E. (GR)
P. (GR)
J. (GR)
A. (GR)
N. (GR)
M. (GR)
V. (GR)
O. (GR)
I. (USA)
K. (GR)
M. (CY)
S. (USA)
N. (GR)
S. (CH)
S. (USA)
10