Luminaries in Medicine: EDWARD JENNER

LUMINARIES IN MEDICINE
SJIM
VOLUME 3 NO. 1
1434 H - 2013 G
Luminaries in Medicine: EDWARD JENNER
Mohammed W. Al-Rabia1, md, phd and Hussein A. Algahtani2, md, frcpc
1
Department of Medicine, Faculty of Medicine, King Abdulaziz University and 2College of Medicine King Saud bin
Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia
&EXBSE +FOOFS UIF
man who discovered
UIF TNBMMQPY WBDDJOF
the very first vaccine in
the history of mankind,
was born on May 17,
1749 in the small town
of
Gloucestershire,
#FSLFMFZ
&OHMBOE
When he was 5,
his
parents
died,
thus
giving
the
responsibility to his
eldest brother to look
Edward Jenner
after him. At the age of
(1749-1823)
14, he started medical
education in a local
school near Bristol for 7 years. In 1770, he became a student
BU4U(FPSHFhT)PTQJUBMJO-POEPOBOEBUSBJOFFVOEFSUIF
TVQFSWJTJPOPG+PIO)VOUFSBHSFBUTVSHFPOBOEBOBUPNJTU
+FOOFS XBT JOTQJSFE CZ )VOUFST BCJMJUJFT UIBU DPOTJEFSFE
him his role-model and established a close friendship.
#FTJEFTTUVEZJOHNFEJDJOF+FOOFSXBTBDVSJPVTOBUVSBMJTU
FOKPZJOH PCTFSWBUJPO PG OBUVSF DPMMFDUJOH EBUB PG CJSET
migration, hibernation of specific species and the biological
cycle of eels.
*O&EXBSE+FOOFSEFDJEFEUPQSBDUJDFNFEJDJOF
in a farm community to be a country doctor at Berkeley,
EJTSFHBSEJOH B TVHHFTUJPO UP QSBDUJDF JO -POEPO +FOOFS
was not only a successful physician, but also a vigorous
countryman with an active social life. He had many
hobbies like singing, playing musical instruments and
XSJUJOHQPFUSZ *O+FOOFSFBSOFEIJT.%EFHSFFGSPN
the University of St Andrews. He also presented papers on
cardiological aspects, such as mitral stenosis and coronary
artery diseases. He helped to establish many local medical
TPDJFUJFTBOEXBTBGFMMPXPGUIF-JOOBFBO4PDJFUZ
*O UIF UI DFOUVSZ TNBMMQPY XBT B DBUBTUSPQIJD
EJTFBTF UIBU XBT HSFBUMZ GFBSFE CZ FWFSZPOF BOE B NBKPS
LJMMFS PG IVNBOT 4NBMMQPY XBT QFSDFJWFE BT B VOJWFSTBM
DVSTFCFGPSF+FOOFSTEJTDPWFSZ5PEJTDPWFSUIFTNBMMQPY
vaccine, he used a perceptive combination of scientific logic
and common sense to make use of his own observations
PO DPXQPY DBTFT )F VTFE IJT UIFPSFUJDBM DPODFQUT BOE
observations to piece together a scientific development
that created a remarkable lifesaving path to mankind.
*OIFPCTFSWFEUIBUBMMNJMLNBJETXFSFJOGFDUFE
XJUIDPXQPYBOPOGBUBMEJTFBTFUPIVNBOTBOESFNBJOFE
GSFF PG TNBMMQPY BMUIPVHI UIFZ XFSF FYQPTFE UP UIF
TNBMMQPYJOGFDUJPOGSPNIPVTFIPMEDBTFT&EXBSE+FOOFS
IZQPUIFTJ[FEUIBUHFUUJOHDPXQPYXBTBTBGF XBZUPQSPUFDU
QFPQMF GSPN TNBMMQPY FTUBCMJTIJOH GPS UIF ĕSTU UJNF B
link of cross-protection between the two diseases. With
continuous studying of more people previously infected
XJUI DPX QPY BOE XIP GBJMFE UP SFTQPOE UP JOPDVMBUJPO
XJUI TNBMMQPY PS UP DBUDI UIF EJTFBTF IF DPODMVEFE UIBU
QVTUBLFOGSPNBDPXQPYJOGFDUFEQFSTPOBUUIFQFBLPG
UIF EJTFBTF XPVME QSPWJEF QSPUFDUJPO BHBJOTU TNBMMQPY
+FOOFSTJEFBXBT NFUXJUIXJEFTQSFBETLFQUJDJTN*OGBDUIF
XBTUISFBUFOFEUPCFFYQVMTFEGSPNNFEJDJOFJGIFCSPVHIU
VQ UIF TVCKFDU BHBJO )JT PCTFSWBUJPOT BOE DPODMVTJPOT
were not welcomed in the medical society and gained very
little response. A manuscript, describing his findings and
theories, was denied from publication by the Royal Society
and he was obliged to publish his 'Inquiry' privately.
ćF IJHIMZ EJTDPVSBHJOH SFDFQUJPO PG +FOOFST EJTDPWFSZ
among medical professionals was significantly mitigated.
However, some progress had been made when a surgeon of
4UćPNBTT)PTQJUBMXIPVTFEUIFUSFBUNFOUXJUITVDDFTT
ćF SFDPHOJUJPO PG +FOOFST JEFBT BOE EJTDPWFSZ IBE
HSBEVBMMZHBJOFENPNFOUVNSFBDIJOHBQFBLJOXIFO
the British parliament nominated him with 20,000 pounds
in recognition of his valuable services and sacrifices. As
FBSMZBTTNBMMQPYWBDDJOBUJPOXBTNBEFDPNQVMTPSZ
JO #BWBSJB BOE TJODF UIFO NPTU &VSPQFBO HPWFSONFOUT
have either encouraged or compelled vaccination to the
QFPQMFćFNPTUNBHOJĕDFOUBTQFDUPG+FOOFSTEJTDPWFSZ
PGBTNBMMQPYWBDDJOFXBTFSBEJDBUFECFGPSFQFPQMFLOFX
UIBUWJSVTFTFYJTUFEPSUIFJNNVOFTZTUFNPGIVNBOTIBE
much been characterized.
"UUIFBHFPGJO&EXBSE+FOOFSTMJGFFOEFE
due to a stroke. More than 150 years passed after his death,
CFGPSF TNBMMQPY XBT ĕOBMMZ FSBEJDBUFE CZ UIF 6OJWFSTBM
Address for Correspondence:
Dr. Mohammed W. Al-Rabia
Department of Medicine, Facuty of Medicine
King Abdulaziz University
P.O. Box 6880, Jeddah 21452, Saudi Arabia
e-M: [email protected]
Saudi Journal of Internal Medicine Vol. 4 No. 1 - 2014
7
Campaign of Vaccination, reported by World Health
Organization in the 1970s. By his death, humanity lost one
of the greatest scientists in medical history, a true benefactor
PGNBOLJOE)PXFWFS&EXBSE+FOOFSJTTUJMMSFNFNCFSFE
BT B SPMF NPEFM PG IPX IF VTFE (PET HJWFO JOUFMMJHFODF
curiosity, and simple logic to pursue a scientific path that
BJNFEUPIFMQPUIFST)JTEJTDPWFSZPGUIFTNBMMQPYWBDDJOF
gave hope to humanity, and he showed that with dedication
and perseverance, diseases can be defeated.
&EXBSE +FOOFS MFE UIF QBUI UP EJTDPWFSJFT BOE
ingenuities for future generation. His spirit, curiosity,
perseverance, and his way of thinking continue to advance
in the field of vaccinology for many decades after his
death. The 20th century has witnessed greatest successes in
developing vaccines that protect against once commonly
fatal infections such as pertussis, diphtheria, tetanus,
polio, measles, rubella, and several other communicable
diseases. With success, there are also setbacks and missed
opportunities in medicine as many hard to eradicate or
to treat diseases are presently active. Malaria, dengue and
tuberculosis continue to defy a vaccine solution despite all
TDJFOUJĕDFČPSUTUIBUBSFCFJOHTQFOUPOUIFJSEFWFMPQNFOU
BOESFTFBSDI/FWFSUIFMFTT+FOOFSDPOUJOVFTUPCFBNFOUPS
UP UIF GVUVSF NFEJDBM DPNNVOJUZ UIVT UIFSF BSF TUJMM
TJHOJĕDBOUHBQTJOPVSVOEFSTUBOEJOHPGUIFTFQBUIPHFOT
however, there is hope and certainly, challenging scientists
are working hard in developing vaccines that will eradicate
diseases for the future of humanity.
References
t
4NJUI,"&EXBSE+FOOFSBOEUIFTNBMMQPYWBDDJOF'SPOU
*NNVOPM
t
%VOO1.%S&EXBSE+FOOFS
PG#FSLFMFZBOE
WBDDJOBUJPO BHBJOTU TNBMM QPY "SDI %JTFBTF $IJME 'FUBM
/FPOBUBM&E
''
t
3PXF",3PXF4:4OPX38,PSFOSPNQ&-4DIFMMFOCFSH
+34UFJO$/BIMFO#-#SZDF+#MBDL3&4UFLFUFF38ćF
burden of malaria mortality among African children in the
ZFBS*OU+&QJEFNJPM
t
Montañés C M, Gicquel B. New tuberculosis vaccines.
&OGFSN*OGFDD.JDSPCJPM$MJO4VQQM
t
Hokey DA, Ginsberg A. The current state of tuberculosis
WBDDJOFT )VN 7BDDJO *NNVOPUIFS 2146.
t
ćPNBT4+&OEZ51$VSSFOUJTTVFTJOEFOHVFWBDDJOBUJPO
$VSS0QJO*OGFDU%JT
8
Saudi Journal of Internal Medicine Vol. 4 No. 1 - 2014