LUMINARIES IN MEDICINE SJIM VOLUME 3 NO. 1 1434 H - 2013 G Luminaries in Medicine: EDWARD JENNER Mohammed W. Al-Rabia1, md, phd and Hussein A. Algahtani2, md, frcpc 1 Department of Medicine, Faculty of Medicine, King Abdulaziz University and 2College of Medicine King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia &EXBSE +FOOFS UIF man who discovered UIF TNBMMQPY WBDDJOF the very first vaccine in the history of mankind, was born on May 17, 1749 in the small town of Gloucestershire, #FSLFMFZ &OHMBOE When he was 5, his parents died, thus giving the responsibility to his eldest brother to look Edward Jenner after him. At the age of (1749-1823) 14, he started medical education in a local school near Bristol for 7 years. In 1770, he became a student BU4U(FPSHFhT)PTQJUBMJO-POEPOBOEBUSBJOFFVOEFSUIF TVQFSWJTJPOPG+PIO)VOUFSBHSFBUTVSHFPOBOEBOBUPNJTU +FOOFS XBT JOTQJSFE CZ )VOUFST BCJMJUJFT UIBU DPOTJEFSFE him his role-model and established a close friendship. #FTJEFTTUVEZJOHNFEJDJOF+FOOFSXBTBDVSJPVTOBUVSBMJTU FOKPZJOH PCTFSWBUJPO PG OBUVSF DPMMFDUJOH EBUB PG CJSET migration, hibernation of specific species and the biological cycle of eels. *O&EXBSE+FOOFSEFDJEFEUPQSBDUJDFNFEJDJOF in a farm community to be a country doctor at Berkeley, EJTSFHBSEJOH B TVHHFTUJPO UP QSBDUJDF JO -POEPO +FOOFS was not only a successful physician, but also a vigorous countryman with an active social life. He had many hobbies like singing, playing musical instruments and XSJUJOHQPFUSZ *O+FOOFSFBSOFEIJT.%EFHSFFGSPN the University of St Andrews. He also presented papers on cardiological aspects, such as mitral stenosis and coronary artery diseases. He helped to establish many local medical TPDJFUJFTBOEXBTBGFMMPXPGUIF-JOOBFBO4PDJFUZ *O UIF UI DFOUVSZ TNBMMQPY XBT B DBUBTUSPQIJD EJTFBTF UIBU XBT HSFBUMZ GFBSFE CZ FWFSZPOF BOE B NBKPS LJMMFS PG IVNBOT 4NBMMQPY XBT QFSDFJWFE BT B VOJWFSTBM DVSTFCFGPSF+FOOFSTEJTDPWFSZ5PEJTDPWFSUIFTNBMMQPY vaccine, he used a perceptive combination of scientific logic and common sense to make use of his own observations PO DPXQPY DBTFT )F VTFE IJT UIFPSFUJDBM DPODFQUT BOE observations to piece together a scientific development that created a remarkable lifesaving path to mankind. *OIFPCTFSWFEUIBUBMMNJMLNBJETXFSFJOGFDUFE XJUIDPXQPYBOPOGBUBMEJTFBTFUPIVNBOTBOESFNBJOFE GSFF PG TNBMMQPY BMUIPVHI UIFZ XFSF FYQPTFE UP UIF TNBMMQPYJOGFDUJPOGSPNIPVTFIPMEDBTFT&EXBSE+FOOFS IZQPUIFTJ[FEUIBUHFUUJOHDPXQPYXBTBTBGF XBZUPQSPUFDU QFPQMF GSPN TNBMMQPY FTUBCMJTIJOH GPS UIF ĕSTU UJNF B link of cross-protection between the two diseases. With continuous studying of more people previously infected XJUI DPX QPY BOE XIP GBJMFE UP SFTQPOE UP JOPDVMBUJPO XJUI TNBMMQPY PS UP DBUDI UIF EJTFBTF IF DPODMVEFE UIBU QVTUBLFOGSPNBDPXQPYJOGFDUFEQFSTPOBUUIFQFBLPG UIF EJTFBTF XPVME QSPWJEF QSPUFDUJPO BHBJOTU TNBMMQPY +FOOFSTJEFBXBT NFUXJUIXJEFTQSFBETLFQUJDJTN*OGBDUIF XBTUISFBUFOFEUPCFFYQVMTFEGSPNNFEJDJOFJGIFCSPVHIU VQ UIF TVCKFDU BHBJO )JT PCTFSWBUJPOT BOE DPODMVTJPOT were not welcomed in the medical society and gained very little response. A manuscript, describing his findings and theories, was denied from publication by the Royal Society and he was obliged to publish his 'Inquiry' privately. ćF IJHIMZ EJTDPVSBHJOH SFDFQUJPO PG +FOOFST EJTDPWFSZ among medical professionals was significantly mitigated. However, some progress had been made when a surgeon of 4UćPNBTT)PTQJUBMXIPVTFEUIFUSFBUNFOUXJUITVDDFTT ćF SFDPHOJUJPO PG +FOOFST JEFBT BOE EJTDPWFSZ IBE HSBEVBMMZHBJOFENPNFOUVNSFBDIJOHBQFBLJOXIFO the British parliament nominated him with 20,000 pounds in recognition of his valuable services and sacrifices. As FBSMZBTTNBMMQPYWBDDJOBUJPOXBTNBEFDPNQVMTPSZ JO #BWBSJB BOE TJODF UIFO NPTU &VSPQFBO HPWFSONFOUT have either encouraged or compelled vaccination to the QFPQMFćFNPTUNBHOJĕDFOUBTQFDUPG+FOOFSTEJTDPWFSZ PGBTNBMMQPYWBDDJOFXBTFSBEJDBUFECFGPSFQFPQMFLOFX UIBUWJSVTFTFYJTUFEPSUIFJNNVOFTZTUFNPGIVNBOTIBE much been characterized. "UUIFBHFPGJO&EXBSE+FOOFSTMJGFFOEFE due to a stroke. More than 150 years passed after his death, CFGPSF TNBMMQPY XBT ĕOBMMZ FSBEJDBUFE CZ UIF 6OJWFSTBM Address for Correspondence: Dr. Mohammed W. Al-Rabia Department of Medicine, Facuty of Medicine King Abdulaziz University P.O. Box 6880, Jeddah 21452, Saudi Arabia e-M: [email protected] Saudi Journal of Internal Medicine Vol. 4 No. 1 - 2014 7 Campaign of Vaccination, reported by World Health Organization in the 1970s. By his death, humanity lost one of the greatest scientists in medical history, a true benefactor PGNBOLJOE)PXFWFS&EXBSE+FOOFSJTTUJMMSFNFNCFSFE BT B SPMF NPEFM PG IPX IF VTFE (PET HJWFO JOUFMMJHFODF curiosity, and simple logic to pursue a scientific path that BJNFEUPIFMQPUIFST)JTEJTDPWFSZPGUIFTNBMMQPYWBDDJOF gave hope to humanity, and he showed that with dedication and perseverance, diseases can be defeated. &EXBSE +FOOFS MFE UIF QBUI UP EJTDPWFSJFT BOE ingenuities for future generation. His spirit, curiosity, perseverance, and his way of thinking continue to advance in the field of vaccinology for many decades after his death. The 20th century has witnessed greatest successes in developing vaccines that protect against once commonly fatal infections such as pertussis, diphtheria, tetanus, polio, measles, rubella, and several other communicable diseases. With success, there are also setbacks and missed opportunities in medicine as many hard to eradicate or to treat diseases are presently active. Malaria, dengue and tuberculosis continue to defy a vaccine solution despite all TDJFOUJĕDFČPSUTUIBUBSFCFJOHTQFOUPOUIFJSEFWFMPQNFOU BOESFTFBSDI/FWFSUIFMFTT+FOOFSDPOUJOVFTUPCFBNFOUPS UP UIF GVUVSF NFEJDBM DPNNVOJUZ UIVT UIFSF BSF TUJMM TJHOJĕDBOUHBQTJOPVSVOEFSTUBOEJOHPGUIFTFQBUIPHFOT however, there is hope and certainly, challenging scientists are working hard in developing vaccines that will eradicate diseases for the future of humanity. References t 4NJUI,"&EXBSE+FOOFSBOEUIFTNBMMQPYWBDDJOF'SPOU *NNVOPM t %VOO1.%S&EXBSE+FOOFS PG#FSLFMFZBOE WBDDJOBUJPO BHBJOTU TNBMM QPY "SDI %JTFBTF $IJME 'FUBM /FPOBUBM&E '' t 3PXF",3PXF4:4OPX38,PSFOSPNQ&-4DIFMMFOCFSH +34UFJO$/BIMFO#-#SZDF+#MBDL3&4UFLFUFF38ćF burden of malaria mortality among African children in the ZFBS*OU+&QJEFNJPM t Montañés C M, Gicquel B. New tuberculosis vaccines. &OGFSN*OGFDD.JDSPCJPM$MJO4VQQM t Hokey DA, Ginsberg A. The current state of tuberculosis WBDDJOFT )VN 7BDDJO *NNVOPUIFS 2146. t ćPNBT4+&OEZ51$VSSFOUJTTVFTJOEFOHVFWBDDJOBUJPO $VSS0QJO*OGFDU%JT 8 Saudi Journal of Internal Medicine Vol. 4 No. 1 - 2014
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