Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry.
This journal is © The Royal Society of Chemistry 2017
Supporting Information
Palladium-Mediated 11C-Carbonylations Using Aryl Halides and
Cyanamide
Patrik Nordeman,‡ Shiao Y. Chow,† Adam F. Odell,§ Gunnar Antoni,‡ and Luke. R. Odell†,*
†
Division of Organic Pharmaceutical Chemistry, ‡Preclinical PET Platform, Department of Medicinal
Chemistry, Uppsala University, Box 574, 75123, Uppsala, Sweden. §School of Medicine, St. James’
University Hospital, University of Leeds, LS9 7TF, Leeds, UK.
Contents
1. Radiochromatograms…………………………………………………………….…….……..….…S-2
2. NMR-spectra.…....……………………………………………………………….………...……....S-8
S-1
1. Radiochromatograms
From the optimization table 1 using analytical method 1. See general information for more information.
The compound 11C-2a is eluting at 1.0 min.
Entry 2, PPh3, 120 °C, RTE= 95%, RCP= 75%.
Entry 3, Xantphos, 120 °C, RTE= 91%, RCP= 61%.
Entry 7, DPEphos, 150 °C, RTE= 82%, RCP= 86%.
Entry 8, dppf, 120 °C, RTE= >99%, RCP= 94%.
S-2
Semipreparative HPLC, collected fraction 12.0-14.0 min.
Pure fraction and reference using analytical method 2.
S-3
Semipreparative HPLC, collected fraction 10.5-12.5
Pure fraction and reference using analytical method 1.
S-4
Semipreparative HPLC, collected fraction 10.5-11.0 min
Collected fraction and reference using analytical method 1.
S-5
Semipreparative HPLC, collected fraction 7.6-8.6 min.
Radio and reference of collected fraction using analytical method 3.
UV of purified fraction using analytical method 3.
S-6
Semipreparative HPLC, collected fraction 10.5-11.2 min
Radio and reference of collected fraction using analytical method 2.
UV of collected fraction using analytical method 2.
S-7
2. NMR spectra
s
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