FIRST GLOBAL LEADERS MEETING
www.ipopi.org
Primary Immunodeficiency Diseases in China
Xiao-Ming Gao, PhD
Department of Immunology
Peking University Health Science Center
Beijing, China
1. The situation
Less than 500 cases
diagnosed in total so far!
50-100 thousand PID
to be diagnosed
Approximately 2500
PID cases annually
25 million newborns each year
in a population of 1.3 billion in
mainland China
Clinically diagnosed PID cases in mainland China
1%
6%
13%
antibody deficiencies
35%
12%
phagocyte deficiencies
well defined
immunodeficiency syndromes
combined T- and B-cell
immunodeficiencies
15%
18%
disease of immune
dysregulation
complement deficiencies
other PID
Genetically diagnosed PID cases in mainland China
1
XLA
1 1
2
WAS
13
4
XHIM
XCGD
XSCID
3
LAD-1 Deficiency
IL-12RB1 Deficiency
12
RAG2 deficiency
Diagnosis of PID cases by one of the centers in China
No. of cases
75
50
25
0
1993-1996 1997-2000
1997-2000
1993-1996
2001-2003 2004-2008
2004-2006
2001-2004
Year
Clinical diagnosed
Genetically diagnosed
2. The PID centers in China
Several PID centers are now in operation in China:
Children’s Hospital of Chongqing Medical University
Headed by Drs. XD Zhao and XQ Yang
JMF Diagnostic Center at the Children’s Hospital
Fudan University, Shanghai
Headed by Dr XC Wang
JMF Diagnostic Center at Peking University, Beijing
Headed by Dr XM Gao
PKU First Hospital of
PKU Third Hospital
Beijing Obstetrics Gynecology Hospital
Professor Xiao-Dong Zhao
Genetic diagnostic of PID
WAS treatment by bone marrow transplantation
PID treatment by stem cell transplantation
The JMF Diagnostic Center at Peking University
• Inaugurated in May, 2005
• In collaboration with
Beijing Children’s Hospital
The First Teaching Hospital of PKU
People’s Hospital of PKU
The 3rd Teaching Hospital of PKU
Beijing Obstetrics Gynecology Hospital
• Assist in genetic and clinical diagnosis of PID cases
• Awareness campaign amongst clinicians and patient families
• Run training courses on PID for clinicians
• Organize international on PID meetings in China
Awareness campaign
The First International Symposium on
Immunodeficiency-related Disorders
May 11-12, 2006, Beijing, China
26 invited speakers from Europe and USA, more than 200
delegates from China and overseas attended the symposium
The First Spring School on Primary Immunodeficiency in China
February 22-25, 2008, Sanya, China
Human Immunology and Immunodeficiencies
May 12-17, 2009
Capital Hotel • Beijing, China
Organizers: Lennart Hammarström, Xiao-Jun Xu,
Jean-Laurent Casanova, and Xiao-Ming Gao
Meeting Topics:
•
•
•
•
Development of Immunity
Antibody Deficiencies
Non-B Cell PIDs
Therapy for Primary Immunodeficiency Diseases
• Genetics of Common Infectious Diseases
• Mechanism of Immunodeficiency in HIV
Early Registration & Scholarship
Deadline: January 12, 2009
Late-Breaking Abstract Deadline: February 11, 2009
Registration Deadline: March 12, 2009
To register or for more information on this and 50+ other conferences, please visit
www.keystonesymposia.org/9D7 or call 1-800-253-0685 or 1-970-262-1230.
Keystone Symposia is a 501(c)3 nonprofit directed and supported by the scientific community.
Conferences provide an opportunity for debate, exchange and learning combined with leisure activities in world-class settings.
University of Hong Kong Medical School
Define novel mutations for primary immunodeficiencies in Hong
Kong and has established HKU as the referral centre for molecular
diagnosis of such diseases for the whole of China and nearby
Asian countries.
3. The support
From international PID related community
PIDnet in China: A project grant under Framework 6
of EU (L. Harmastrom and XM Gao).
JMF, ……
From Universities in China
Support to the PID centers
From the Chinese government
Little so far
From the pharmaceutical industry in China
Some
4. The future
Ability for PID genetic diagnosis to be improved
Chinese government support on PID increases
necessary
A national PID registry to be setup
Awareness campaign should go to smaller cities
and rural areas
Patient support still lacking
……
FIRST GLOBAL LEADERS MEETING
London
October 30th – November 1st 2009
www.ipopi.org