A balanced ecosystem is our key to
sustenance
25 years of excellence in
agrochemical development
Why partner with Advinus?
• Management and scientific leadership team with extensive international experience
• Leading center for regulatory toxicology with the largest animal vivarium in South Asia
and one of Asia’s largest REACH testing facilities
• Experience of over 5,500 successful regulatory GLP submissions and over 1,000 Phys
chem studies
• More than 17 successful audits by global and regional regulatory agencies
• Data generated at Advinus successfully accepted by EPA and OECD countries
• State-of-the-art Pilot plant dedicated to Process Development and Process Validation of
Active Ingredients
Accreditations & Guidelines:
• GLP, OECD, US-EPA, CIPAC, EEC, FAO
At Advinus, we believe in adding continuous value to a more
greener & healthier environment through responsible & quality
agro R&D, Product Life Cycle Management and global
registrations. Being a pioneer in agrochemical development
for 25 years in India, has helped us gain valuable insight
& immense experience to be your reliable partner for
complete Agro Lifecycle Management Solutions.
• NGCMA India
• W&V Netherlands
• Atomic Energy Regulatory Body, Government of India
• BfR Germany
• AAALAC
Infrastructure:
• 220,000 Sq ft
People:
• 450+
Advinus
Agrochemical Development Services
Process Chemistry
Non-Rodent Toxicology
• 5-Batch Synthesis
• Single dose studies
• Custom synthesis of intermediates, exotic raw
materials, impurities/metabolites
• Dose escalation study maximum tolerated
dose
• Route scouting & identification for generic AI’s
• Repeated dose
• Process Development and Optimization of Novel
and/or Non-infringing routes
• Chronic toxicology
• Complete process analytical package including
impurity profiling
ADME Studies
• Process Scale up
• Asymmetric synthesis, chiral separations
• Studies in rodents including mass balance,
tissue distribution in cold and radiolabelled
compound and metabolite identification
• Technology transfer services
Analytical Capabilities
• Patent technical specification preparation and
filing of patents wherever applicable
• Method development/ validation for active
ingredients in different substrates
Analytical Chemistry Capabilities
• Sample analysis for Eco-Toxicology, AirInhalation and Toxicology studies
• Structural characterization
• ADME support
• Impurity profiling
• Analytical method development and validation
Residue Analytical • Preparation of reference and working standards
• Physical & Chemical properties for Technical
AI and Agro-formulations
Genetic Toxicology
• Method Development & Validation
• Bacterial Mutation Assay
• Residue & Persistence in Soil, Water &
Plants (as per GAP & GLP or Non GLP)
• in vitro mouse lymphoma
• in vitro cytogenetic assay
5 Batch Analysis
• in vivo erythrocyte micronucleus assay
• Technical material analysis for AI and
impurities ≥0.1%
• in vivo bone marrow metaphase assay
• Preparation of reference and working standards
Physico-chemical studies
General Toxicology Rodents
• Melting/freezing point
• Single-doset acute (including oral, dermal,
inhalation, irritation and sensitization tests)
• Boiling point
• Repeated dose sub-acute and sub-chronic
studies
• Surface tension
• Chronic toxicology studies
• Carcinogenicity studies
Full range of reproductive and
developmental toxicity studies required for
product registration
• Reproductive toxicology screening to OECD
421 and 422
• Developmental toxicology in rats and rabbits
• Multigenerational studies in rats
• Avian Reproduction studies
• Relative density
• Water solubility
• Partition co-efficient n-octanol/water
• Flash-point
• Flammability
• Oxidising properties
• Stability in organic solvents and identity of
relevant degradation products
• Dissociation constant
• Viscosity
• Photolysis studies
• Explosive properties
• Auto ignition
• Self ignition
E-fate Studies • Hydrolysis as a function of pH
• Aqueous Photolysis
• Adsorption Co-efficient by HPLC
Advinus
Agrochemical Development Services
• Adsorption/Desorption in Soil by Batch
Equilibrium
• Radiolabelled studies
• Persistence Studies (Field & Lab)
• Residue Studies
• Biodegradation
• Ecotox studies in fish, daphnia, algae and
honeybees
Other Services • Authentication of Test Item and Issuing COA
Agro Formulation
• Formulation recipe development of conventional
and new generation formulations
• Improvement of existing formulations
• Development of combination formulations
• Selection and recommendation of the right type
of formulation for development
• Stability studies accelerated and multi-locational
storage
• Supply of samples for field trials and for
toxicological studies
• Pilot plant scale up studies and process
optimization
• Technology transfer for commercial production
Field Trial Support
• Plant analysis for the nutrients
• Soil analysis – physical & chemical properties
• Water analysis on post field trials
• Fertilizer analysis for major & micro nutrients
Process Chemistry:
• 40,000 sq. ft. lab with facilities for Cryo {(-) 1000C}, high temp {(+) 2200C}, High pressure &
Hydrogenation reactions
• 10 Reactors – 20 L AGR , 200 L SSR with capacities of 20 L to 650 L
Advinus
Infrastructure
• Dedicated infrastructure for radiolabeled compounds
• Team includes 56 scientists (14 PhDs, 37 Masters )
Safety Assessment:
• Over 70,000 sq ft. lab
• Species available: Rats, Mice, Guineapigs, Rabbits, Chicken, Pigeons, Quail, Fresh water fish,
Algae, Daphnia, & Honey bees
• Team includes around 108 scientists (10 PhDs, 8 DABTs)
Analytical R&D:
• Lab area: approx. 4000 sq. ft. with separate facility for radiotracer studies
• Team includes 25 Research scientists( 2 PhDs and 20 Masters)
• Equipments include LC-MS/MS (API 2000, API 4000), GC-MS, HPLC-UV/PDA/-RAM, and GCECD/NPD/FID, Suntest Apparatus and instruments for Phys-Chem studies
Agro-Formulations:
• 2000 sq ft of dedicated laboratory with necessary equipments like ribbon blenders, air jet
mills, dyno mills, extruder, homogenizer and spray granulator
• 500 sq. ft of dedicated pilot plants for scale-up experiments
• Full-fledged analytical laboratories with GCs, HPLCs, viscometer, KF titrators, UV-VIS
spectrophotometers
[email protected]
© 2013: ADVINUS