TECHNICAL DATA SHEET
Osteo™
Osteoporosis literally means “porous bone”. Osteoporosis affects more than 20
million people in the United States. Normally, there is a decline in bone mass after
the age of 35 to 40 years of age for both sexes (approximately 2% loss per year).
Women are at a much greater risk for osteoporosis because they often have lower
bone density prior to age 35. Many factors can result in excessive bone loss such as
a low calcium-high phosphorus intake, high protein diet, lack of physical exercise,
high consumption of soft drinks, high salt intake, and trace mineral deficiencies.
Coffee, alcohol and smoking cause negative calcium balance and are associated
with an increased risk of developing osteoporosis. Osteo™ formula contains the
three most clinically accepted and bioavailable forms of calcium along with essential
bone building and strengthening ingredients, which contribute to a highly successful
solution to osteoporosis prevention. Now available with 800 IU of Vitamin D3!
INGREDIENTS:
S u p p l e m e n t
F a c t s
Serving size: 3 capsules
Servings per container: 30
%DV
Amount per serving
Vitamin D3 (as Cholecalciferol)
800 IU
200%
Vitamin K2 (with MK-5,6 & 7)
400 mcg
500%
Calcium (as Citrate)
200 mg
20%
Calcium (as Citrate-Malate)
200 mg
20%
Calcium (as Microcrystalline hydroxyapatite)
200 mg
20%
Magnesium (as Citrate-Malate)
100 mg
25%
Ipriflavone (from soy)
100 mg
*
Horsetail (Equisetum) concentrate (4:1) (aerial parts)
50 mg
*
Sea trace minerals (organic)
25 mg
*
1.5 mg
100 mcg
*
*
Boron (as aspartate)
Vanadium (as vanadyl sulfate)
Percent Daily Values are based on a 2,000 calorie diet.
* Daily Value not established.
Other Ingredients: Gelatin capsules
Calcium
Calcium in the body is over 99% contained in the bones and
teeth. Calcium balance is generally positive during growth,
neutral in the mature adult, and negative in older adults.
Osteo™ contains the three most clinically accepted forms of
calcium: calcium citrate, calcium citrate-malate, and calcium
hydroxyapatite (200mg of each form per serving). Calcium
citrate is assimilated even in low acid producing patients and
is more easily absorbed than calcium carbonate (1). Calcium
citrate-malate, a combination of citric and malic acids, is
regarded by many researchers to be the most bioavailabe
form of calcium. Within the industry, there appears to be a
form of calcium wars involving calcium citrate verses calcium
hydroxyapatite for which form is the best. Regardless, both
forms are acknowledged to be highly absorbable while
reducing the risk of osteoporosis. Calcium microcrystalline
hydroxyapatite is a calcium compound that contains
minerals in their natural ratios, as well as residues of matrix,
proteins, and glycosamino glycans (2). Recent clinical
studies indicate that microcrystalline hydroxyapatite is more
effective in increasing bone thickness than any other form of
calcium.
Ipriflavone
Ipriflavone is an isoflavone derived from soy. Ipriflavone
enhances osteoblast function and inhibits bone resorption,
mainly by inhibiting recruitment of osteoclasts (3). Evidence
suggests that ipriflavone prevents bone density loss without
suppressing the rate of bone formation (unlike 17-beta estradiol which suppresses the rate of bone formation) (4).
Ipriflavone is effective in inhibiting the breakdown of existing
bone, while increasing the formation of new bone. Ipriflavone
supports Type I collagen and the formation of mineralized
bone matrix, further supporting healthy bone synthesis.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Ipriflavone (continued)
Several clinical studies indicate that individuals who took
calcium without ipriflavone suffered greater bone loss than
those who took ipriflavone with calcium further indicating the
efficacy of ipriflavone in maintaining healthier bone formation.
Magnesium
Magnesium is the second most plentiful cation in the
intracellular fluid and the most plentiful cation in the body.
Magnesium is involved with more than 300 enzyme systems.
About a third of skeletal magnesium is on the surface of the
bone and acts as a reservoir to maintain the extra cellular
magnesium concentration. The remaining two-thirds of
magnesium in bone is a constituent of bone crystals and is not
readily available as a magnesium source (5). Magnesium
deficiency leads to impairment of osteoblast (bone building
cells) function, according to research. There is also evidence
that magnesium deficiency increases the formation and activity
of osteoclasts (bone resorbing cells).
Boron
Boron is a trace mineral and is important in mineral metabolism
(10). Diets higher in boron seem to increase serum 17-betaestradiol levels in postmenopausal women using estrogen
replacement therapy (11). Boron is essential for proper bone
formation.
Vanadium
Vanadium is a trace mineral that appears to be important in
normal bone growth and proper bone formation.
Sea Trace Minerals
Sea trace minerals are organically derived and provide many
necessary nutrients no longer found in today’s diet. Sea trace
minerals are included to enhance the growth and strength of the
bone.
Vitamin K
Vitamin K promotes strong bones by speeding up the healing
of fractures and increasing bone density (6). Alan Gaby MD
recently published an article investigating recent clinical trials
that suggest Vitamin K is more effective and safer than
conventional treatments for osteoporosis. For example, a
longterm study of Alendronate (Fosamax) found 48% reduction
in fracture incidence, as compared with reductions of 50-81%
in the meta analysis of Vitamin K studies. In addition, in
contrast to the absence of severe adverse effects with Vitamin
K, Alendronate can cause severe esophagitis and has been
implicated as a possible cause of osteonecrosis of the jaw
bone.
Vitamin D3 (Cholecalciferol)
Vitamin D3 is a fat-soluble vitamin. Skin exposure to the sun
provides as much as 80% to 90% of the body’s Vitamin D
stores (7). More than 50% of North American women receiving
therapy to prevent or treat osteoporosis have inadequate
Vitamin D stores (8). Factors such as lack of exposure to
sunlight, reduced skin synthesis of Vitamin D, lower dietary
intake, impaired intestinal absorption, and reduced metabolism
to active forms of Vitamin D by the kidneys, increase with aging
(9). Vitamin D promotes optimal bone health by stimulating the
absorption of calcium.
Patients: Consult with your healthcare professional
for the proper dosage and use of this formula.
For more information about this and other Condition
Specific Formulas® please visit our website at:
Horsetail (Equisetum)
Horesetail contains equisetonin and flavone glycosides that
contain silica. Silica is essential for proper bone formation.
www.mpn8.com
Portland, OR 97225
REFERENCES:
1. J Clinical Pharmacol 1999;39:1151-4
2. Postgrad Med J 1985; 61:791-6
3. Bone Miner 1992;19 Suppl 1:S35-42
4. Calcif Tissue Int 2000;66(1):61-5
5. Eur J Intern Med 2004;15:97-107
6. Am J Clin Nutr 2000;71:1201-8
7. Proc Nutr Sci 1997;56:915-37
8. J Clin Endocrinol Metab 2005;90:3215-24
9. Am J Clin Nutr 2002;75:611-5
10. Environ Health Perspect 1994;102:65-72
11. Modern Nutrition in Health and Disease 1994; Shils M. Olson A., Shike M.