Chlorinated Pharmaceuticals
Created by the Njardarson Group (The University of Arizona): Brandon R. Smith, Candice M. Eastman, Jón T. Njarðarson
Calcium Chloride Potassium Chloride Chloromycetin
pHisoHex
Tace
Chlor-Trimeton
Clonidine Ethchlorvynol Phenoxybenzamine
Nesacaine
Ambenonium Halothane Atarax
Compazine
Leukeran
Diuril
Thorazine
Trilafon
Diabinese
Chlorprothixene
Parafon
Vancocin
( Calcium Chloride )
( Potassium Chloride )
( Chloramphenicol )
( Hexachlorophene )
( Chlorotrianisene )
( Chlorpheniramine & Pseudoephedrine )
( Clonidine )
( Ethchlorvynol )
( Phenoxybenzamine )
( Chloroprocaine )
( Ambenonium )
( Halothane )
( Hydroxyzine )
( Prochlorperazine )
( Chlorambucil )
( Chlorothiazide )
( Chlorpromazine )
( Perphenazine )
( Chlorpropamide )
( Chlorprothixene )
( Chlorzoxazone )
( Vancomycin )
ALM*, BBO, GUS
ALM*, BBO
AIN*, DER, GUS, SEN
DERMATOLOGICAL
GENITO-URINARY & SEX HORMONE
NER, RES
NER*, CAR, SEN
NERVOUS SYSTEM
CARDIOVASCULAR
NERVOUS SYSTEM
NERVOUS SYSTEM
NERVOUS SYSTEM
NERVOUS SYSTEM
NERVOUS SYSTEM
ONCOLOGICAL
CARDIOVASCULAR
NERVOUS SYSTEM
NERVOUS SYSTEM
ALIMENTARY TRACT & METABOLISM
NERVOUS SYSTEM
MUSCULO-SKELETAL
ANTI-INFECTIVE
Approved 1900s
Approved 1920s
Approved 1949
Approved 1949
Approved 1950
Approved 1950
Approved 1950
Approved 1950
Approved 1953
Approved 1955
Approved 1956
Approved 1956
Approved 1956
Approved 1956
Approved 1957
Approved 1957
Approved 1957
Approved 1957
Approved 1958
Approved 1958
Approved 1958
Approved 1958
Cytoxan
Hydrochlorothiazide Librium
Trancopal
Clomifene
Clomipramine Doburil
Declomycin
Methoxyflurane Enduron
Chlorhexidine Daranide
Grisactin
Aldoril
Valium
Alkeran
Triavil
Maolate
Serax
Dyazide
Clomocycline Enflurane ( Cyclophosphamide )
( Hydrochlorothiazide )
( Chlordiazepoxide )
( Chlormezanone )
( Clomifene )
( Clomipramine )
( Cyclothiazide )
( Demeclocycline )
( Methoxyflurane )
( Methyclothiazide )
( Chlorhexidine )
( Dichlorphenamide )
( Griseofulvin )
( Methyldopa & Hydrochlorothiazide )
( Diazepam )
( Melphalan )
( Amitriptyline & Perphenazine )
( Chlorphenesin )
( Oxazepam )
( Triamterene & Hydrochlorothiazide )
( Clomocycline )
( Enflurane )
ONCOLOGICAL
CAR*, END
NERVOUS SYSTEM
MUSCULO-SKELETAL
GENITO-URINARY & SEX HORMONE
NER*, END
CARDIOVASCULAR
AIN, DER
NERVOUS SYSTEM
CARDIOVASCULAR
SEN*, ALM, BBO, DER, RES
SENSORY ORGAN
DERMATOLOGICAL
CARDIOVASCULAR
NERVOUS SYSTEM
ONCOLOGICAL
NERVOUS SYSTEM
DERMATOLOGICAL
NERVOUS SYSTEM
CARDIOVASCULAR
ANTI-INFECTIVE
NERVOUS SYSTEM
Approved 1959
Approved 1959
Approved 1960
Approved 1960
Approved 1960
Approved 1960
Approved 1960
Approved 1960
Approved 1960
Approved 1960
Approved 1960s
Approved 1960s
Approved 1962
Approved 1962
Approved 1963
Approved 1964
Approved 1965
Approved 1965
Approved 1965
Approved 1965
Approved 1966
Approved 1966
Lasix
Atromid-S
Haldol
Pathocil
Cleocin
Floxapen
Dalmane
Ketalar
Lysodren
Tranxene
Hyperstat
Sanorex
Cloxapen
Monistat 7
Klonopin
Lotrimin
Loxitane
Vanceril
CeeNU
Imodium
Limbitrol DS
Lioresal
( Furosemide )
( Clofibrate )
( Haloperidol )
( Dicloxacillin )
( Clindamycin )
( Flucloxacillin )
( Flurazepam )
( Ketamine )
( Mitotane )
( Clorazepate )
( Diazoxide )
( Mazindol )
( Cloxacillin )
( Miconazole )
( Clonazepam )
( Clotrimazole )
( Loxapine )
( Beclomethasone )
( Lomustine )
( Loperamide )
( Amitriptyline & Chlordiazepoxide )
( Baclofen )
CARDIOVASCULAR
BBO, CAR
NERVOUS SYSTEM
ANTI-INFECTIVE
AIN, DER, GUS
ANTI-INFECTIVE
NERVOUS SYSTEM
NERVOUS SYSTEM
ONCOLOGICAL
NERVOUS SYSTEM
CARDIOVASCULAR
ALIMENTARY TRACT & METABOLISM
ANTI-INFECTIVE
AIN*, ALM, DER, GUS, SEN
NERVOUS SYSTEM
ALM*, GUS*, DER
NERVOUS SYSTEM
ALM, DER, RES
ONCOLOGICAL
ALIMENTARY TRACT & METABOLISM
NERVOUS SYSTEM
MUSCULO-SKELETAL
Approved 1966
Approved 1967
Approved 1967
Approved 1968
Approved 1970
Approved 1970
Approved 1970
Approved 1970
Approved 1970
Approved 1972
Approved 1973
Approved 1973
Approved 1974
Approved 1974
Approved 1975
Approved 1975
Approved 1975
Approved 1976
Approved 1976
Approved 1976
Approved 1977
Approved 1977
BiCNU
Tavist
Cloderm
Ativan
Platinol
Aldactazide
Buclizine Ceclor
Forane
Reglan
Inderide
Adinazolam Asendin
Halotex
Meclomen
Domperidone Xanax
Moduretic
Midamor
Emcyt
Paxipam
Nizoral
( Carmustine )
( Clemastine )
( Clocortolone )
( Lorazepam )
( Cisplatin )
( Spironolactone & Hydrochlorothiazide )
( Buclizine )
( Cefaclor )
( Isoflurane )
( Metoclopramide )
( Propranolol & Hydrochlorothiazide )
( Adinazolam )
( Amoxapine )
( Haloprogin )
( Meclofenamate )
( Domperidone )
( Alprazolam )
( Amiloride & Hydrochlorothiazide )
( Amiloride )
( Estramustine )
( Halazepam )
( Ketoconazole )
ONCOLOGICAL
RES*, NER
DERMATOLOGICAL
NERVOUS SYSTEM
ONCOLOGICAL
CARDIOVASCULAR
RESPIRATORY SYSTEM
ANTI-INFECTIVE
NERVOUS SYSTEM
ALIMENTARY TRACT & METABOLISM
CARDIOVASCULAR
NERVOUS SYSTEM
NERVOUS SYSTEM
DERMATOLOGICAL
MUSCULO-SKELETAL
ALIMENTARY TRACT & METABOLISM
NERVOUS SYSTEM
CARDIOVASCULAR
CARDIOVASCULAR
ONCOLOGICAL
NERVOUS SYSTEM
AIN, DER, GUS
Approved 1977
Approved 1977
Approved 1977
Approved 1977
Approved 1978
Approved 1978
Approved 1979
Approved 1979
Approved 1979
Approved 1979
Approved 1979
Approved 1980
Approved 1980
Approved 1980
Approved 1980
Approved 1980s (CAN)
Approved 1981
Approved 1981
Approved 1981
Approved 1981
Approved 1981
Approved 1981
Restoril
Aclovate
Spectazole
Halcion
Lozol
TZ-3
Tenoretic
Lotrisone
Capozide
Lopressor HCT
Wellbutrin
Femstat
Temovate
Versed
Progabide Lamprene
Vaseretic
Tenex
Trazodone Zopiclone Iopidine
Tussicaps
( Temazepam )
( Alclometasone )
( Econazole )
( Triazolam )
( Indapamide )
( Tioconazole )
( Atenolol & Chlorthalidone )
( Betamethasone Dipropionate & Clotrimazole )
( Captopril & Hydrochlorothiazide )
( Metoprolol & Hydrochlorothiazide )
( Bupropion )
( Butoconazole )
( Clobetasol )
( Midazolam )
( Progabide )
( Clofazimine )
( Enalapril & Hydrochlorothiazide )
( Guanfacine )
( Trazodone )
( Zopiclone )
( Apraclonidine )
( Chlorpheniramine & Hydrocodone )
NERVOUS SYSTEM
DER, SEN
DER, GUS
NERVOUS SYSTEM
CARDIOVASCULAR
DER, GUS
CARDIOVASCULAR
DERMATOLOGICAL
CAR*, END
CARDIOVASCULAR
NERVOUS SYSTEM
GENITO-URINARY & SEX HORMONE
DERMATOLOGICAL
NERVOUS SYSTEM
NERVOUS SYSTEM
ANTI-INFECTIVE
CARDIOVASCULAR
CARDIOVASCULAR
NER*, END
NERVOUS SYSTEM
SENSORY ORGAN
NERVOUS SYSTEM
Approved 1981
Approved 1982
Approved 1982
Approved 1982
Approved 1983
Approved 1983
Approved 1984
Approved 1984
Approved 1984
Approved 1984
Approved 1985
Approved 1985
Approved 1985
Approved 1985
Approved 1985
Approved 1986
Approved 1986
Approved 1986
Approved 1986
Approved 1986
Approved 1987
Approved 1987
Mykrox
Elocon
Terazol 7
Voltaren
Ifex
Oxistat
Metahydrin
Clozaril
Prinzide
Prosom
Moclobemide Plendil
Lorabid
Zoloft
Tilid
Lotensin HCT
Sporanox
Ziac
Propulsid
Leustatin
Lipidil
Claritin
( Metolazone )
( Mometasone )
( Terconazole )
( Diclofenac )
( Ifosfamide )
( Oxiconazole )
( Trichlormethiazide )
( Clozapine )
( Lisinopril & Hydrochlorothiazide )
( Estazolam )
( Moclobemide )
( Felodipine )
( Loracarbef )
( Sertraline )
( Ticlopidine )
( Benazepril & Hydrochlorothiazide )
( Itraconazole )
( Bisoprolol & Hydrochlorothiazide )
( Cisapride )
( Cladribine )
( Fenofibrate )
( Loratadine )
CARDIOVASCULAR
DER, RES
GENITO-URINARY & SEX HORMONE
MSK, SEN
ONCOLOGICAL
DER, GUS
CARDIOVASCULAR
NERVOUS SYSTEM
CARDIOVASCULAR
NERVOUS SYSTEM
NERVOUS SYSTEM
CARDIOVASCULAR
ANTI-INFECTIVE
NER, GUS
BLOOD & BLOOD FORMING ORGAN
CARDIOVASCULAR
AIN*, GUS
CARDIOVASCULAR
ALIMENTARY TRACT & METABOLISM
ONCOLOGICAL
BBO*, CAR*, END
RESPIRATORY SYSTEM
Approved 1987
Approved 1987
Approved 1987
Approved 1988
Approved 1988
Approved 1988
Approved 1988
Approved 1989
Approved 1989
Approved 1990
Approved 1990
Approved 1991
Approved 1991
Approved 1991
Approved 1991
Approved 1992
Approved 1992
Approved 1993
Approved 1993
Approved 1993
Approved 1993
Approved 1993
Monopril-HCT
Lamictal
Claritin-D
Serzone
Lotrel
Zyrtec
Hyzaar
Cozaar
Astelin
Lexxel
Zanaflex
Agrylin
Plavix
Arthrotec
Corlopam
Glyburide
Avalide
Meridia
Fareston
Sustiva
Lotemax
Singulair
( Fosinopril & Hydrochlorothiazide )
( Lamotrigine )
( Loratadine & Pseudoephedrine )
( Nefazodone )
( Amlodipine & Benazepril )
( Cetirizine )
( Losartan & Hydrochlorothiazide )
( Losartan )
( Azelastine )
( Enalapril & Felodipine )
( Tizanidine )
( Anagrelide )
( Clopidogrel )
( Diclofenac & Misoprostol )
( Fenoldopam )
( Glibenclamide )
( Irbesartan & Hydrochlorothiazide )
( Sibutramine )
( Toremifene )
( Efavirenz )
( Loteprednol Etabonate )
( Montelukast )
CARDIOVASCULAR
NERVOUS SYSTEM
NERVOUS SYSTEM
NERVOUS SYSTEM
CARDIOVASCULAR
RESPIRATORY SYSTEM
CARDIOVASCULAR
CARDIOVASCULAR
RES*, SEN
CAR*, END
MUSCULO-SKELETAL
BBO, ONC
BBO*, END*, CAR
ALIMENTARY TRACT & METABOLISM
CARDIOVASCULAR
BBO, END
CARDIOVASCULAR
ALM, END
END, ONC
ANTI-INFECTIVE
SENSORY ORGAN
RESPIRATORY SYSTEM
Approved 1994
Approved 1994
Approved 1994
Approved 1994
Approved 1995
Approved 1995
Approved 1995
Approved 1995
Approved 1996
Approved 1996
Approved 1996
Approved 1997
Approved 1997
Approved 1997
Approved 1997
Approved 1997
Approved 1997
Approved 1997
Approved 1997
Approved 1998
Approved 1998
Approved 1998
Diovan HCT
Norvasc
Accuretic
Benzaclin
Atacand HCT
Cetrotide
Glucovance
Micardis HCT
Zyrtec-D
Clarinex D 24 Hour
Clarinex
Teveten HCT
Elidel
Geodon
Abilify
Plenaxis
Carbinoxamine Iressa
Benicar HCT
Ertaczo
Caduet
Advil A.S.
( Valsartan & Hydrochlorothiazide )
( Amlodipine )
( Quinapril & Hydrochlorothiazide )
( Benzoyl Peroxide & Clindamycin )
( Candesartan & Hydrochlorothiazide )
( Cetrorelix )
( Glyburide & Metformin )
( Telmisartan & Hydrochlorothiazide )
( Cetirizine & Pseudoephedrine )
( Desloratadine & Pseudoephedrine )
( Desloratadine )
( Eprosartan & Hydrochlorothiazide )
( Pimecrolimus )
( Ziprasidone )
( Aripiprazole )
( Abarelix )
( Carbinoxamine )
( Gefitinib )
( Olmesartan & Hydrochlorothiazide )
( Sertaconazole )
( Amlodipine & Atorvastatin )
( Chlorpheniramine, Pseudoephedrine & Ibuprofen )
CARDIOVASCULAR
CARDIOVASCULAR
CARDIOVASCULAR
DERMATOLOGICAL
CARDIOVASCULAR
GENITO-URINARY & SEX HORMONE
ALIMENTARY TRACT & METABOLISM
CAR, END
NERVOUS SYSTEM
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM
CARDIOVASCULAR
DERMATOLOGICAL
NERVOUS SYSTEM
NERVOUS SYSTEM
GUS, ONC
RESPIRATORY SYSTEM
ONC, RES
CARDIOVASCULAR
DERMATOLOGICAL
BBO, CAR
NERVOUS SYSTEM
Approved 1998
Approved 1999
Approved 1999
Approved 2000
Approved 2000
Approved 2000
Approved 2000
Approved 2000
Approved 2001
Approved 2001
Approved 2001
Approved 2001
Approved 2001
Approved 2001
Approved 2002
Approved 2003
Approved 2003
Approved 2003
Approved 2003
Approved 2003
Approved 2004
Approved 2004
Clolar
Lunesta
Zylet
Nexavar
Ziana
Sprycel
Atripla
AZOR
Exforge
Fenofibric Acid
Tykerb
Xyzal
Tekturna HCT
Treanda
Cleviprex
Degarelix
Saphris
Bepreve
Besivance
Zipsor
Vibativ
Samsca
( Clofarabine )
( Eszopiclone )
( Loteprednol Etabonate & Tobramycin )
( Sorafenib )
( Clindamycin & Tretinoin )
( Dasatinib )
( Emtricitabine, Tenofovir Disoproxil & Efavirenz )
( Amlodipine & Olmesartan )
( Amlodipine & Valsartan )
( Fenofibric Acid )
( Lapatinib )
( Levocetirizine )
( Aliskiren & Hydrochlorothiazide )
( Bendamustine )
( Clevidipine )
( Degarelix )
( Asenapine )
( Bepotastine )
( Besifloxacin )
( Diclofenac )
( Telavancin )
( Tolvaptan )
ONCOLOGICAL
NERVOUS SYSTEM
SENSORY ORGAN
ALM, ONC
DERMATOLOGICAL
ONCOLOGICAL
ANTI-INFECTIVE
CARDIOVASCULAR
CARDIOVASCULAR
CARDIOVASCULAR
ONCOLOGICAL
DER, RES
CARDIOVASCULAR
ONCOLOGICAL
CARDIOVASCULAR
GUS, ONC
NERVOUS SYSTEM
SENSORY ORGAN
ANTI-INFECTIVE
NERVOUS SYSTEM
AIN, DER
BLOOD & BLOOD FORMING ORGAN
Approved 2004
Approved 2004
Approved 2004
Approved 2005
Approved 2006
Approved 2006
Approved 2006
Approved 2007
Approved 2007
Approved 2007
Approved 2007
Approved 2007
Approved 2008
Approved 2008
Approved 2008
Approved 2008
Approved 2009
Approved 2009
Approved 2009
Approved 2009
Approved 2009
Approved 2009
Tekamlo
Amturnide
Dulera
Tribenzor
Onfi
Xalkori
Dificid
Xarelto
Daliresp
Zelboraf
Stendra
Dymista
Bosulif
Stribild
Belviq
Stivarga
Erivedge
BEP
BEACOPP
CHOP
CMF
CVP
( Aliskiren & Amlodipine )
( Aliskiren, Amlopidine & Hydrochlorothiazide )
( Mometasone & Formoterol )
( Olmesartan Medoxomil, Amlopidine & Hydrochlorothiazide )
( Clobazam )
( Crizotinib )
( Fidaxomicin )
( Rivaroxaban )
( Roflumilast )
( Vemurafenib )
( Avanafil )
( Azelastine & Fluticasone )
( Bosutinib )
( Cobicistat, Elvitegravir, Emtricitabine & Tenofovir Disoproxil )
( Lorcaserin )
( Regorafenib )
( Vismodegib )
( Bleomycin, Etoposide & Cisplatin )
( Bleomycin, Etoposide, Doxorubicin, Cyclophosphamide, Vincristine,
Procarbazine & Prednisone )
( Cyclophosphamide, Doxorubicin, Vincristine & Prednisone )
( Cyclophosphamide, Methotrexate & Fluorouracil )
( Cyclophosphamide, Vincristine, & Prednisone )
CARDIOVASCULAR
CARDIOVASCULAR
RESPIRATORY SYSTEM
CARDIOVASCULAR
NERVOUS SYSTEM
ONC, RES
AIN, ALM
BBO, CAR
RESPIRATORY SYSTEM
DER, ONC
GUS, MSK
RESPIRATORY SYSTEM
BBO, ONC
ANTI-INFECTIVE
ENDOCRINE SYSTEM
ALM, ONC
DER, ONC
ONCOLOGICAL
ONCOLOGICAL
ONCOLOGICAL
ONCOLOGICAL
ONCOLOGICAL
Approved 2010
Approved 2010
Approved 2010
Approved 2010
Approved 2011
Approved 2011
Approved 2011
Approved 2011
Approved 2011
Approved 2011
Approved 2012
Approved 2012
Approved 2012
Approved 2012
Approved 2012
Approved 2012
Approved 2012
Not Approved+
Not Approved+
Not Approved+
Not Approved+
Not Approved+
C-VAMP
( Cyclophosphamide, Vincristine, Doxorubicin & Methylprednisolone )
COPP
( Cyclophosphamide, Vincristine, Procarbazine & Prednisone )
AC
ABVE-PC
( Doxorubicin & Cyclophosphamide )
( Doxorubicin, Bleomycin, Vincristine, Etoposide, Prednisone &
Cyclophosphamide )
AC-T
( Doxorubicin, Cyclophosphamide & Paclitaxel )
EPOCH
( Etoposide, Prednisone, Vincristine, Cyclophosphamide & Doxorubicin )
Gemcitabine-Cisplatin
( Gemcitabine & Cisplatin )
ICE
Stanford V
MOPP
R-CHOP
R-CVP
VeIP
( Ifosfamide, Carboplatin & Etoposide )
( Mechlorethamine, Doxorubicin, Vinblastine, Vincristine, Bleomycin,
Etoposide & Prednisone )
( Mechloroethamine, Vincristine, Prednisone & Procarbazine )
( Rituximab, Cyclophosphamide, Doxorubicin, Vincristine & Prednisone )
( Rituximab, Cyclophosphamide, Vincristine & Prednisone )
( Vinblastine, Ifosfamide, Cisplatin, & Mesna )
ONCOLOGICAL
ONCOLOGICAL
ONCOLOGICAL
ONCOLOGICAL
ONCOLOGICAL
ONCOLOGICAL
ONCOLOGICAL
ONCOLOGICAL
ONCOLOGICAL
ONCOLOGICAL
ONCOLOGICAL
ONCOLOGICAL
ONCOLOGICAL
Not Approved+
Not Approved+
Not Approved+
Not Approved+
Not Approved+
Not Approved+
Not Approved+
Not Approved+
Not Approved+
Not Approved+
Not Approved+
Not Approved+
Not Approved+
All drugs are considered FDA approved in the U.S. following the passage of the Pure Food and Drugs Act in 1906.
http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/
* The FDA approval year and Market Name is representative of the first three-letter abbreviation of the disease category (see legend) in the series.
+
This drug has also been FDA approved for additional disorders.
` According to the National Cancer Institute (http://www.cancer.gov), chemotherapy regimens do not have an official FDA approval, however, each individual molecular component is FDA approved.
CATEGORY ABBREVIATIONS
ALM
ALIMENTARY TRACT & METABOLISM
AIN
ANTI-INFECTIVE
BBO
BLOOD & BLOOD FORMING ORGANS
CAR
CARDIOVASCULAR SYSTEM
DER
DERMATOLOGICAL
END
ENDOCRINE SYSTEM
GUS
GENITO-URINARY & SEX HORMONES
MSK
MUSCULO-SKELETAL SYSTEM
NER
NERVOUS SYSTEM
ONC
ONCOLOGICAL
RES
RESPIRATORY SYSTEM
SEN
SENSORY ORGANS