S. Apte, R. Sarangarajan (Eds.)
Cellular Respiration and Carcinogenesis
▶ Provides first glimpse into cutting-edge research
▶ Opens a new dialogue in regards to the Warburg hypothesis
2009, XI, 195 p.
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Cellular Respiration and Carcinogenesis informs the reader about both basic and recent
research in the field of cellular respiration and the effects of its dysfunction, alteration or
attenuation on the development of cancer. This masterfully compiled text by leading
experts in the field, offers the reader a fundamental understanding about how oxygen
sensing and/or availability, programmed cell death, immune recognition and response
and glucose metabolism are intimately linked with the two major mechanisms or
pathways of cellular respiration; oxidative phosphorylation and glycolysis. The editors and
contributing authors proficiently and unequivocally address the effects of dysfunction of
the mitochondrial oxidative phosphorylation/glycolysis (cellular respiration) mechanisms
and pathways on the development of cancer. While it remains true that there are no
universal truths in cancer, Cellular Respiration and Carcinogenesis opens the dialogue that
the etiology of cancer can usually be associated with and significantly attributed to the
failure of one or multiple pathways of oxidative phosphorylation to normally burn fuel to
generate energy, vis-à-vis the Warburg hypothesis. Keeping with its cutting-edge nature,
Cellular Respiration and Carcinogenesis provides the first glimpse of cautionary evidence
based counterbalance to the recent and rapidly proliferating notion that utilization of fuel
primarily via glycolysis is a hallmark of cancer development.
About the Editors:
Shireesh P.Apte, Ph.D has 10+ years experience in the pharmaceutical industry
researching and formulating anti-cancer drugs. He holds one US patent and has 10+
related publications. He is a member of the US Pharmacopoeia excipients expert
committee.
Rangaprasad Sarangarajan, Ph.D. has over 10 years of research experience in an academic
setting with extensive publications in areas of pharmacology & toxicology with focus on
cancer treatment. He is active member of various professional organizations including the
Society of Toxicology, American Society for Pharmacology & Toxicology and Pan American
Society for Pigment Cell Research.
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