® KPD Performance Comparison NKR vs. UNOS 11/19/2014 Version 2.4 Summary With the recent publication of “The State of the OPTN/UNOS KPD Pilot Program” we now have publicly available statistics confirming that patients experience shorter wait times and significantly improve their chance of receiving a kidney transplant when participating in the NKR paired exchange program 2 Pool Size Eligible patient candidates as of 4/21/14 281 Pairs 256 The UNOS and NKR paired exchange pools are roughly the same size. UNOS NKR 3 Transplants Facilitated Transplants Inception – 3/31/14 Although the pools are about the same size, NKR has facilitated over 10 times as many transplants as the UNOS program. 1010 88 UNOS NKR 4 Patients still waiting after 18 months 35% Two and a half times as many patients are still waiting for a transplant in the UNOS program after 18 months. 14% UNOS NKR 5 Patients transplanted after 18 months Five times as many patients are transplanted through the NKR program after 18 months. 54% 10% UNOS NKR 6 Patients transplanted after 12 months Six times as many patients are transplanted through the NKR program after 12 months. 41% 7% UNOS NKR 7 Blood Type "O" Recipients Transplanted From 7/1/10 – 3/31/14 (excludes NKR CHIPs) NKR transplants one and a half times as many hard to match “O” blood type patients than the UNOS program 47% 31% UNOS NKR 8 Transplanted patients >95% cPRA From 7/1/10 – 3/31/14 (excludes NKR CHIPs) NKR transplants more of the hard to match very highly sensitized patients than the UNOS program 19% 17% UNOS NKR 9 Comparison Statistics Transplant Volume Transplants Facilitated Since Inception Transplants Facilitated in 2013 Transplants Facilitated in Q1 2014 UNOS 88 52 9 NKR 1010 308 87 Variance -922 -256 -78 Variance % -91% -83% -90% Participating Centers Active Participating Centers 138 98 75 59 63 39 84% 66% Monthly Addition of Pairs Q1 2014 NDDs Enrolled Since Inception 28 55 45 223 -17 -168 -38% -75% Patients Available for Matching 4/2014 Donors Available for Matching 4/2014 256 270 295 355 -39 -85 -13% -24% Match Offers per Month Q1 2014 Transplants per Match Offer Q1 2014 44 20% 263 33% -219 -13% -83% Who was transplanted (7/1/10 – 3/31/14) Blood Type "O" Recipients Recipients with cPRAs >80% Recipients with cPRAs >95% 31% 32% 17% 47% 34% 19% -16% -2% -2% Matching Success Rates Transplanted via program after 12 months Transplanted via program after 18 months Still waiting in KPD program after 12 months Still waiting in KPD program after 18 months 7% 10% 49% 35% 41% 54% 33% 14% -34% -44% 16% 21% DGF Cases DGF Percentage 2 2.4% 59 5.8% -57 -3.4% -3.4% Graft Failures within 6 months Graft Failure % within 6 months 1 1.1% 14 1.4% -13 -0.2% -0.2% 10 Conclusion Patients are much more likely to be transplanted with less wait time if enrolled in the NKR paired exchange program 11 Source Documents 1. UNOS Report dated 3/31/2014 http://optn.transplant.hrsa.gov/ContentDocuments/KPD_Report.pdf 2. NKR Quarterly Report dated 3/31/2014 http://www.kidneyregistry.org/pages/p294/NKR_ReportQ1_2014.php 3. NKR Member Center Online reporting system 12
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