Coatings
Calcium phosphate coating on implants
made by additive manufacturing methods
medical implant solutions
Coatings
BONIT® coating on additive manufacturing made
implants
Implants made by additive manufacturing methods display porous surface structures suitable for ingrowth of bone tissue. To promote and accelerate bone ingrowth and osseointegration a bioactive BONIT® (Calcium phosphate) coating
can be applied on the structured and porous surface.
Properties
•
•
•
•
•
•
•
Thin coating thickness (~20 µm)
Adhesive strength exceeds ≥ 15 MPa
Outstanding capillarity for uptaking of blood
Ca/P-ratio of the coating is 1,1 ± 0,1
Phase composition ≥ 70 % brushite / ≤ 30 % HA
No particles flaking off
„Non-line-of sight“ Technology
„Non-line-of sight“ Technology of BONIT®
Due to the „non line of sight“ process technology BONIT® coating is also suitable for porous structures, manufactured
by additive manufacturing techniques. Deposition from a solution enables a complete and homogenous coverage of
porous surface structures.
BONIT®
coating
Porous
surface
Implant
Titanium-Plasma-Spray (TPS) Surface on an implant
TPS + BONIT® on an implant
Coatings
Why BONIT® coating on your structured implant?
BONIT® coating leads to a faster and better osseointegration of your implant.
More Bone Deposition with BONIT®
Significantly more bone ongrowth
after 12 weeks through bioactive
BONIT® coating was evaluated in an
animal study in minipigs [1]
48,8
50
40
TPS/BONIT®
30
TPS
22,4
%
Corundum blasted
20
Glass beads
10,5
10
1,9
0
Proven Gap-bridging Capacity
Accelerated gap bridging by BONIT®
coating after 4 and 8 weeks in minipigs (circular gap ~ 1 mm) [2]
40
32,25
30
%
TPS
20
TPS/BONIT®
12,49
10
0,7
0
0
4 weeks
8 weeks
40
High Push-out Values
Extremely High Push out values for
BONIT® coated samples [3]
35,01
Titanium (corundum blasted)
30
Titanium + NCD
N/mm2
20
16,32
16,77
11,95
10
Titanium + NCD + BMP-2
Titanium + TPS + CaP
(BONIT)
0
Outstanding capillarity
High capillarity of BONIT® coated
samples for uptaking of blood and
growth factors
Fast Bone Formation in vivo
Bone formation on BONIT® coated
hip stem, explanted after six weeks
without BONIT® I with BONIT®
without BONIT® I with BONIT®
0 seconds
27 seconds
Coatings
Advantages of BONIT®
Literature
• Fine crystalline structure with
large free surface
• Complete and even coverage of
porous surfaces and complex
implant shapes
• Microporosity with high capillarity
• Simultaneous bone formation
and coating substitution
• Replacement by autologous
bone
• Outstanding biocompatibility
• Thin coating thickness
• Optimal solubility
• Faster and better osseointegration
1.
Schwarz et al.: The transcortical Göttingen Minipig Model for testing osteointegration of implant surfaces and the influence of a soluble CaP coating on osteointegration. Abstract 5901; 5 World Congress
of Biomechanics, Munich 2006 (Citation: Journal of Biomechanics 2006; Vol. 39 Suppl.1, page S10).
2.
Schwarz et al.: Effect of a resorbable CaP coating on bone-implant contact and density in a gap model
after 4 weeks and 8 weeks. An experimental study in Göttinger Minipigs. 52nd Annual Meeting of the
Orthopaedic Research Society. Paper No. 0869.2006.
3.
S. Tschofen: Osseointegration von nanokristallinen Diamantoberflächen, Zirkonoxid und Kalziumphosphat im Schafstibiamodell. Diplomarbeit im Rahmen des Dia-Life-Projektes an der Medizinischen Universität Innsbruck, Universitätsklinik für MKG-Chirurgie
Further Literature on BONIT®
•
McAffee P. et al.: Analysis of porous ingrowth in intervertebral disc prostheses. A nonhuman primate
model. SPINE Volume 28, Number 4, pp.332-340.2003.
•
Mockwitz J.& Dathe V.: Ergebnisse nach zementfrei implantierten Fenurschaftendoprothesen vom
Modell Hofheim nach einer Laufzeit von 10 Jahren. Orthopädische Praxis 38, 4:260-267.2002.
•
Pimenta L. et al.: Zervikaler Bandscheibenersatz. Die PCM-Zwischenwirbel-Endoprothese. Jatros Orthopädie 1/2005.16-18.
•
Reigstad O. et al.: Improved Bone In growth and fixation with a thin calcium phosphate coating
intended for complete resorption. Journal of Biomedical Materials Research: Part B- Applied Biomaterials. 2007.
•
Szmukler-Moncler S. et al.: Evaluation of BONIT, a fully resorbable CaP coating obtained by electrochemical deposition after 6 w of healing : A pilot study in the pig maxillae. Key Engineering Materials,
DOT GmbH
medical implant solutions
A Member of the Eifeler-Holding
Tel: +49(0)381-4 03 35-0
Charles-Darwin-Ring 1a
Fax: +49(0)381-4 03 35-99
18059 Rostock
[email protected]
Germany
www.dot-coating.de
F-BONIT-080115-EN
Vol 192-195, 2001, Trans Tech Publications, Switzerland, 395-398, Bio-ceramics 13.2001.