Grants awarded by MNDRIA for 36 new projects commencing in 2016 $3.32 million contributed by MNDRIA and $1.75 million contributed by Cure for MND Foundation. Total $5.07 million awarded for three 3-year fellowships and 33 grants-in-aid. POSTDOCTORAL FELLOWSHIPS (2016-2018) Dr Michelle Farrar University of NSW Dr Fleur Garton University of QLD Dr John Lee University of QLD Beryl Bayley MND Postdoctoral Fellowship Motor neurone diseases in children and young people – understanding pathophysiology and developing treatment approaches Bill Gole MND Postdoctoral Fellowship Identification of novel genetic loci and pathways associated with ALS through interrogation of multiple integrated genomics data sets MNDRIA Postdoctoral Fellowship The role of C3aR signalling in slowing down the disease progression of MND COLLABORATION GRANTS-IN-AID Cure for MND Collaboration Initiative Prof Julian Gold Neuroscience Trials Australia Grant Pilot Trial of antiretroviral therapy for ALS Prof Gilles Guillemin Macquarie Univesity Cure for MND Collaboration Initiative Grant New directions for early diagnosis of MND: a largescale longitudinal analysis of multiple biomarkers to find diagnostic and prognostic “fingerprints”. Dr Bradley Turner Florey Institute of Neuroscience & Mental Health Dr Peter Crouch University of Melbourne Cure for MND Collaboration Initiative Grant A synergistic approach for treatment of MND using neurotrophic and gene therapy Jenny Barr Smith MND Collaboration Grant A/Prof Tracey Dickson University of Tasmania Graham Stanford MND Collaboration Grant Drug-specific biomarkers to facilitate clinical translation of CuII(atsm) as a potential therapeutic for MND. Inhibitory dysfunction in the cortex: Tackling MND from the top down GRANTS-IN-AID A prospective study to assess the causes and treatment of sleep disordered breathing and respiratory failure in patients with MND DNA damage and neurodegeneration in ALS/MND Dr Vinod Ayappan Flinders University Graham Lang Memorial & Mavis Gallienne MND Research Grants A/Prof Julie Atkin Macquarie University Cure for MND Foundation Research Grant Dr Catherine Blizzard University of Tasmania MNDRIA Grant-in-aid Investigating synaptic dysfunction in ALS Prof Roger Chung Macquarie University Cure for MND Foundation Research Grant New approaches to plasma biomarker studies in MND/ALS Dr Nicholas Cole Macquarie University Cure for MND Foundation Research Grant Elucidating the Pathogenesis of Sporadic Motor Neurone Disease Using Zebrafish Models Dr Peter Crouch University of Melbourne MNDRIA Grant-in-aid Proteomic investigation of functional copper deficiency in MND: Implications for Cu(atsm) as a novel therapeutic. A/Prof Tracey Dickson University of Tasmania Jen Simko MND Research Grant Inhibitory dysfunction in ALS: A systematic human pathophysiology analysis Dr Archa Fox University of WA Rosalind Nicholson MND Research Grant Investigating novel stress responsive structures in MND Dr Nimeshan Geevasinga Uniersity of Sydney Peter Stearne Grant for Familial MND Pathophysiological and diagnostic biomarkers of familial and sporadic amyotrophic lateral sclerosis Research Dr Robert Henderson University of QLD CCR MonSTaR Foundation MND Research Using biomarkers to explore heterogeneity of motor neurone disease Grant Dr Matthew Horrocks University of Wollongong MNDRIA Grant-in-aid Single-molecule detection of the cytotoxic species associated with MND Dr Albert Lee Macquarie University MNDRIA Grant-in-aid Identifying mechanisms responsible for ubiquitination of TAR DNA-binding protein 43 (TDP43) in ALS pathogenesis. Dr Michael Lee University of Sydney MNDRIA Grant-in-aid Dissecting the mechanisms underlying muscle fatigue in ALS using acute and cumulative resistance exercise A/Prof Guillaume Lessene Walter & Eliza Hall IMR Cure for MND Foundation Research Grant Novel Agents to Prevent Neuronal Apoptosis in Motor Neuron Disease Dr Marco Morsch Macquarie University Cure for MND Foundation Research Grant Does the transfer of ALS protein aggregates between motor neurons trigger neurodegeneration? A/Prof Greg Neely University of Sydney MNDRIA Grant-in-aid Conserved regulators of synaptic transmission and MND A/Prof Peter Noakes University of QLD Cure for MND Foundation Research Grant Exploiting the opposing actions of complement receptors C3aR and C5aR1 in the treatment of MND. Dr Susanna Park University of Sydney A/Prof Kenneth Rodgers University of Technology Sydney Dr Mary-Louise Rogers Flinders University MND Ice Bucket Challenge Grant Cure for MND Foundation Research Grant In vivo markers of ALS disease activity – linking structure to function Identification of environmental risk factors for sporadic motor neurone disease in Australia Cure for MND Foundation Research Grant Development of novel Immunogenes to improve growth factor support for motor neurons Dr Darren Saunders University of NSW Neale Daniher MND Research Grant Ubiquitin Depletion as a Cause of Amyotrophic Lateral Sclerosis (ALS). Dr Sandy Shultz University of Melbourne Mick Rodger & Benalla Act to d'feet MND Research Grant Treatment with GSK2606414 in mouse models of motor neurone disease and traumatic brain injury Dr Frederik Steyn University of QLD Dr Lachlan Thompson Florey Institute for Neuroscience & Mental Health Dr Adam Walker Macquarie University Cunningham Family MND Research Grant Cure for MND Foundation Research Grant Metabolic and gut dynamics in MND: Identifying novel strategies to meet energy needs in patients Towards cell-based therapies for MND: identifying and tackling practical challenges in pre-clinical research. Cure for MND Foundation Research Grant Pre-clinical therapeutic testing and biochemical changes associated with neuron survival in a validated TDP-43 mouse model of MND Dr Kelly Williams Macquarie University MNDRIA Grant-in-aid Identification of phenotypic modifiers in sporadic ALS through systems genomics Dr Shu Yang Macquarie University MNDRIA Grant-in-aid Ubiquitin Proteasome System dysfunction as a biomarker for the diagnosis and prognosis of MND Dr Justin Yerbury University of Wollongong Cunningham Family MND Research Grant Development of a biocompatible functionalised liposome drug delivery system to increase efficiency of delivery to motor neurons.
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