Setting the standard for haemostats
Contents
•
The need for haemostats
•
What is Celox?
•
Benefits
•
How it works
•
Performance
•
New Celox Rapid
The need for haemostats in
trauma
Combat lives can be saved
Preventable Combat Death
Extremity Hemorrhage
Tension pneumothorax
Airway obstruction
60 % of preventable battlefield deaths are from
extremity hemorrhage.
Ref WDMET study
Civilians bleeding to death
Trauma: leading cause of death for persons under 40.
Haemorrhage is the cause of death in around 40 % of civilian trauma.
Rapid action
saves lives
What is Celox?
Celox –Proven hemostasis in problem clotting.
• EFFECTIVE: Celox Gauze is consistently top performing haemostat in
evaluations.
• SAFE: Celox Gauze is a tested, safe product.
• PROVEN: published results from the field and independent studies.
• ANTI-COAGULANTS: Celox Gauze works on extreme cases including anticoagulated, anti-platelet and others.
• FAST: Celox speeds up treatment
The Celox range
•
Granules
•
•
15g
35g
•
Applicator
•
Gauze
•
•
•
10ft roll
5 ft Z fold
NEW Rapid Gauze
Celox Gauze
• Gauze with Celox granules
bonded to surface.
• Preferred format of
military and most
emergency services.
• Can be used in challenging
environments.
How Celox works
Physical action – no clotting cascade needed
Using Celox gauze.
Adapted from MoD guidelines.
This is ideally a two-person technique
Operator 2
Operator 1
Open a fresh bandage
Open Celox Gauze
Apply pressure into
the wound through
dressing.
Now work closely together
Remove dressing
Apply pressure through
bandage for 3 minutes.
1
2
3
Insert Celox Gauze,
packing wound tightly
Packing gauze
• Identify bleeding site.
• Pack directly onto source of
bleeding maintaining pressure
on bleed point.
Pack as taught in controlling severe bleeding for first
aid courses – don’t wrap.
Safe
• Tested to highest category (Class III) European Medical Device, as
well as FDA requirements, meets ISO 10993.
• No heat produced
• Not pro-thrombotic.
• Not allergenic, no proteins.
• Same chitosan active since 2006. No adverse events.
•
Chitosan from Shellfish:
– tested on patients with known shellfish sensitivity. No allergies.
• Chitosan metabolised by lysosyme
Performance
US Department of Defense 2012 study
Survival.
Celox 90 %,
Blood loss
n=10 each group
Combat Gauze is called Quikclot in Europe, where it is only licensed for ‘moderate
bleeding’, not severe or ‘life-threatening bleeding’.
Evidence of Celox Gauze performance
Three published, independent studies compare Celox Gauze with Combat Gauze and/or
Chitogauze.
•
ONR study using DoD consensus model 20121.
•
OHSU article using care under fire model 20112.
•
Tactical evacuation scenario 20103.
Two clinical papers on Military4,5 and Civilian5 EMS use.
•
Afghanistan use and air ambulance.
1.
2.
3.
4.
5.
Rall JM et al. Report #TR-2012-22. NMRU, San Antonio.
Watters JM, et al. J Trauma. 2011 Jun;70(6):1413-9.
D Morehouse. Defence Global Nov. 2010, 15-19.
Pozza M, Millner R. Europ J Emerg Med 18(1):31-33 Feb 2011.
Tan ECTH, Bleeker CP. MCI Forum 3(4): 11-15, 2011.
All studies collated: Celox Gauze #1.
100%
80%
60%
Celox Gauze
Chitogauze
40%
Combat Gauze
20%
0%
ONRmodel
2012
DoD
Hemostasis
Hemostasis
ONR 2012
Morehouse
Tactical
evac.
Evacuation intact
Model
CareWatters
under fire
Hemostasis
model
Evacuation intact
Hemostasis. Watters 2011
The next generation
The fastest battlefield haemostat
The Rapid Treatment
•
The fastest haemostatic agent.
•
Works with just 60 second compression.
•
Controls the most severe bleeding.
•
Saves blood – saves lives.
The latest generation
Cuts treatment time in half
4
Minutes
3
2
1
0
3 minute gauze
packing
Celox Rapid
compression
Summary
• EFFECTIVE: Celox Gauze is consistently top performing haemostat in
evaluations.
• SAFE: Celox Gauze is a tested, safe product.
• PROVEN: published results from the field and independent studies.
• ANTI-COAGULANTS: Celox Gauze works on extreme cases including anticoagulated, anti-platelet and others.
• FAST: Celox speeds up treatment
Thank you