1. No category

trans-[Cu(Pir)2(THF)2]

 trans-[Zn(Pir)2(EtOH)2] trans-[Cu(Pir)2(THF)2] trans-[Cu(Pir)2(THF)2] ! trans-[Ni(Pir)2(EtOH)2]
DNA
$ %" #
#&' ()' *+ ,- .
/012
........................................................................................................................................................ ........................................................................................................................................................ ..................................................................................................................................................... .......................................................................................................................................................................... !" #$"% &'(") *+ ,-. / 0 : .......................................................................................................................... %& '()#$ NSAIDs !" . ......................................................................................................................................................... *+,- 3 .................................................................................................................................... *+,-/ 01 !2 .............................................................................................................................................. *+,-/ 5$( 4 ............................................................................................................................... *+,-/ !$7 ( 6 4 ....................................................................... %& !2 " *+,-/ ' '()89: ;) '#) . 6 ......................................................................................................................... *+,-/ %9(9<9- !2 . ....................................................................................................... #00 => 01 = %9(? #) *+,-/ . ......................................................................................................... #00 01 = %9(? #) *+,-/ @ ......................................................................................................... #00 # 01 = %9(? #) *+,-/ 4 @ ......................................................................................................................... *+,-/ !># 'A+BC2- 4 F ......................................................................................................... *+,-/ 'A+BC2- DE$, 5$($+ 6 F ..................................................................................................................................... *+,-/ 2? D,0+ . ................................................................................................................................... *+,-/ !0HI J G 4
,/1% 23/ :& 4 ......................................................................................................................................................................... #E
4 .............................................................................................................. L$ 9 M1$ 9 8K7 4 .................................................................................................................................................. NO 9 4 ......................................................................................................................................................... 1$ 4 ................................................................................................................................................... ABC2P 5$( 4 .......................................................................................................... trans-[Cu(Pir)2(THF)2] ABC2P 5$( 44 ........................................................................................................ trans-[Zn(Pir)2(EtOH)2] ABC2P 5$( 46 ........................................................................................................ trans-[Ni (Pir)2(EtOH)2] ABC2P 5$( 4 4. ........................................................................................... 5$( MABC2P 9BT> 'RS 'Q 6 4. .......................................................................................................... trans-[Cu(Pir)2(THF)2]A+BC2- 9BT> 6 4G ......................................................................................................... trans-[Zn(Pir)2(EtOH)2] A+BC2-9BT> 6 4U ........................................................................................................ trans-[Ni(Pir)2(EtOH)2] A+BC2- 9BT> 4 6 4@ ....................................................................................... DNA ) trans [Cu(Pir)2(THF)2] ABC2P V(P D) . 4@ ................................................................................................................................. %P Run W #
> . 43 ........................................................................................................................... X& W DNA ' . 43 .................................................................................................. Fermentas - Z9> W DNA Y7$ 4 . 6
0614* 5/ :& 6 ......................................................................................................................................................................... #E
6. ............................................................................................................................................. IR '[H !) 4
63 .................................................................................................................................... UV-Vis '[H !) 4
. ..................................................................................... trans [Cu(Pir)2(THF)2] ABC2P '9B) $S !) 4 4
.. .................................................................................................................................. 1H NMR '[H !) 6 4
G4 .................................................................................................................................... A+BC2- 'K(? #5\> . 4
G4 ...................................................................... DNA trans [Cu(Pir)2(THF)2] ABC2P ;) V(-D) !) G 4
G4 .............................................................................. trans [Cu(Pir)2(THF)2] ABC2P A09<9B [H !) U 4
U4 ......................................................................................................................................................... !
0 'X#\$0
U6 .................................................................................................................................................................. '10(&
U. ......................................................................................................................................................................... ]
8 7. #^L:
%9(?
G ............................................................................................................. `" '*+,- !_") $S U ............................................................. A '5B %9 ) [B$7 '*+,- 'A+BC2- '"> $S 3 ......................................................................................................................... *+,-/ #(
) $S 4 F .......................................................................................................... *+,-/ 'aX2 'a10 6 F ....................................................................................................... *+,-/ 8L$ !2 '$S . ......................................................................................................... *+,-/ ''(T>9: ;>/ G ............................................................................................................................... *+,-/ 5$( O U 4 ..........................................................................................................*+,-/ '9( !09 '* @ 6 ................................................................................... %& ''(T>9: T> *+,-/ % #09>/ 3 . ................................................................................ VO(Pir)2H2O (d) #(
) $S ([) $S F G .......................................................... '(Y) +0(d) eA([) ) *+,-/ 'A+BC2- $S U .................................................................. [B$7 '*+,- ) (II)A 'A+BC2- '"> $S U ................................................................... *+,-/ ) (II)A 'A+BC2- !_") ORTEP $S 4 3 .................................................................. ;,BX *+,-/ !># '!- !B- '$S 9 6 3 ..................................... ;0f&( *+,-/ !># '!- ') (/ '$S '9 . ............................................................................................................................ *,P 2? D,0 '2
6 ............................................................................................................................... DNA !2 $S G +
G ...................................................................... Z-DNA BeA #) g eDNA [B$7 'V& U +
44 .....................................................................................................trans-[Cu(Pir)2(THF)2] A+BC2- 5$( '2
46 ................................................................................................... trans-[Zn(Pir)2(EtOH)2] A+BC2- 5$( '2
4. ................................................................................................... trans-[Ni(Pir)2(EtOH)2] A+BC2- 5$( 4 '2
RS DNA DNA + *+,-/ eDNA + A+BC2- : #) g >> #) 'aX) '#0920 +
6F ................................................................................................................................................................... (#Ej 4F)
6.)RS DNA DNA + *+,-/ eDNA + A+BC2- : #) g >> #) 'aX) '#0920 +
6F ......................................................................................................................................................................... (#Ej
6 .....................................................................................................trans-[Cu(Pir)2(THF)2] A+BC2- 5$( 4 '2
64 ................................................................................................... trans-[Zn(Pir)2(EtOH)2] A+BC2- 5$( 4 '2
64 ................................................................................................... trans-[Ni(Pir)2(EtOH)2] A+BC2- 5$( 4 4 '2
6G ............................................................................................... (KBr kj) *+,-/ 01 FT-IR [H 4 +
6U ............................................................................... (KBr kj) !090&9( *+,-/ 01 FT-IR [H 4 +
6U ...................................................................... (KBrkj) trans-[Cu(Pir)2(THF)2] A+BC2- FT-IR [H 4 4 +
6@ ................................................................... (KBr kj) trans-[Zn(Pir)2(EtOH)2] A+BC2- FT-IR [H 6 4 +
6@ .................................................................. (KBr kj) trans-[Ni(Pir)2(EtOH)2] A+BC2- FT-IR [H . 4 +
63 ............................................................. ( .*F . lBm DMSO NO)*+,-/ 01 UV-Vis [H G 4 +
.F ............................ ( .*F . lBm DMSO NO) trans-[Cu(Pir)2(THF)2] 'A+BC2- UV-Vis [H U 4 +
.F .......................... ( .*F . lBm DMSO NO) trans-[Zn(Pir)2(EtOH)2] 'A+BC2- UV-Vis [H @ 4 +
. ..........................(.*F . lBm DMSO NO) trans-[Zn(Pir)2(EtOH)2] 'A+BC2- UV-Vis [H 3 4 +
. ................................................................................ trans-[Cu(Pir)2(THF)2] A+BC2- ORTEP *X F 4 +
. ............................................. trans-[Cu(Pir)2(THF)2A+BC2- !0W 09/ #$T0 $S V20 4 +
.G ......................... (4FFK M eDMSO - d6 NO) trans-[Ni(Pir)2(EtOH)2 A+BC2- 1H NMR [H 4 +
.3 .......................... (4FFK M eDMSO - d6 NO) trans-[Cu(Pir)2(THF)2 A+BC2- 1H NMR [H 4 4 +
GF ............................................................................................ AH(o!$0& WN/9- ') ;+2 ', 6 4 +
G ............................................................. (4FFK M eDMSO - d6 NO) *+,-/ 1H NMR [H . 4 +
G ....................... (4FFK M eDMSO - d6 NO) trans-[Zn(Pir)2(EtOH)2] A+BC2- 1H NMR [H G 4 +
DNA DNA+*+,-/ eDNA+A+BC2- : #) g >> #) 'aX) '#0920 ([ U 4 +
DNA DNA+*+,-/ eDNA+A+BC2- : #) g >> #) 'aX) '#0920 (d .(#Ej 4F) RS
GG ....................................................................................................................................................... .(#Ej 6.) RS
GG ....................................................................................................................................... X& W $S @ 4 +
GU ........... X& W (−OH) X ) *+,-/ %90& ;) !0W 09/ +> 2$^ 'O '"> 3 4 +
G@ .... X& W (−CH2OH) X ) *+,-/ %90& ;) !0W 09/ +> 2$^ 'O '"> F 4 +
G3 .................................................X& W (−O−) X ) *+,-/ %90& !0W 09/ +> '9^0 4 +
G3 ....................................................... X& W *+,-/ %90& ;) !0W 09/ ( %D +> 4 +
+ Fish-DNA (!)&)*+,-/ + Fish-DNA e(5T)RS Fish-DNA CD [H !0$+ [H 4 4 +
UF .................................................................................................................. (5j) trans-[Cu(Pir)2(THF)2] A+BC2 trans-[Cu(Pir)2(THF)2] A+BC2- !090&9( *+,-/ 01 9B^ A09<9B [H '#,E 6 4 +
U ............................................................................................................................................................. DMSO NO
dm 9_O DMSO NO trans-[Cu(Pir)2(THF)2] A+BC2- 9B^ A09<9B [H '#,E . 4 +
U ....................................................................................................................................................................... %p,-
9 #^L:
%9(?
F ........................................................... 5$($+ Q #) *+,-/ 5$( 'A+BC2- '"> 4G ................................................................................ trans-[Cu(Pir)2(THF)2] -> MK(? #5\> q$0 4U .............................................................................. trans-[Zn(Pir)2(EtOH)2] -> MK(? #5\> q$0 4U ............................................................................... trans-[Ni(Pir)2(EtOH)2] -> MK(? #5\> q$0 4 .4 ............................................ trans-[Cu(Pir)2(THF)2] A+BC2- $S Vf/ !X9$,- ' 4 .6 ........................................... trans-[Cu(Pir)2(THF)2] A+BC2- ') (Å)!)7$0 '09/ 9H '"> 4 .6 ........................................... trans-[Cu(Pir)2(THF)2] A+BC2- ') (°) !)7$0 '09/ # '"> 4 4 G4 ................................................................................ 5$( 'A+BC2- 'l0 !)\> q$0 ;) #,E 6 4
G6 ............................................................................8"j 0 9$ L$ 9 MW : . 4 ١
:7;
%& ;/ d
$ VP (> #0 ; #P ($, M<$m d
$I M #$ #) rB"$ *,P
!29 #( eV e;9P M%H s0H M9B " M sX0) J #B) e0Jt %) Mf) M
trans- trans-[Zn(Pir)2(EtOH)2] etrans-[Cu(Pir)2(THF)2 MABC2P s>EE^> MW/ ; .0 50 %9S
e 1H-NMReIR eUV Tj s/9$C [B$7 MQ Z9> ABC2P ; .0 5$( [Ni(Pir)2(EtOH)2]
V(PD) eABC2P s0HI 8J s) 9l( #) .0 s( X '#" !X9$,- MK(? 50&
q$0 X j #" 9 CD 9$ W MQ Z9> DNA ) trans- [Cu(Pir)2(THF)2] ABC2P
.9) trans- [Cu(Pir)2(THF)2] ABC2P ) V(PD) J DNA $S o> \ sPO
٢
!" #$"% &'(") *+ ,-. / 0
8 0/4 (CNSAIDs) 0!4? @
4A 08 ,> <=<
%) 'f) ' V- #) \( #- ($, '<$m d
$I ' #$ #) rB"$ u*+,-
.[] 09! ;+,>
'<$ d
$I ' : (>T? #- 09! L$ d
$ % #$ !B- 9H #)
! '!Xp ' '<$m d
$I ' .(NSAID) '<$m d
$I '
: 08T? #- ($, '
[LS x;+,
y
) >
d
$ I
4
.[] !(9 '0X ) V(-D) #) 2> *?
6
2) ! 2^> !1$,) \ *?
.
z
___________________
1
- Non steroidal anti inflammatory drugs
- Oxicams
3
- Analgesic
4
- Antipyretic
5
- Anti-inflammatory
2
٣
: (>T? #- - '()#$ [B$7 X NSAIDs %9>! !B- '()#ETH = u
€
(< "%) ;C& (0 =B, 8E$ COOH
OCOCH3
(< "%)
y
x
(E "%) 9$/ (0 9( 9(& / 8E$ NHCOCH3
(E "%)
OH

z
(F "%) %>9) ( (0 %9/ 8E$ 4
O
O
N
N
(F "%)
___________________
1
- Salicylic acid
- Aspirin
3
- para-aminophenol
4
- Paracetamol
5
- Pyrazolone
6
- Phenylbutazone
2
٤
u
€
(G "%) ;$( (0 ( 8E$ 6
OH
O
O
O
N
(G "%)
Cl
y
x
(H "%) ;/9T (0 =09// 8E$ .
H3 C
COOH
CH 3
CH3
(H "%)
COOH
H3C
CH 3
NH
(I "%)
___________________
1
- Indole
- Indomethacin
3
- Propionic acid
4
- Ibuprofen
5
- Fenamates
6
- Mefanamic acid
2

z
(I "%) =(L (0 8( G
٥
u
€
(J "%) D ‚(9B+ (0 =$ & 8E$ U
COONa
Cl
NH
(J "%)
Cl
y
x
(K "%) *+,-/ (0 *+,- @
O
OH
NH
N
N
S
O
CH3
O
(K "%)
8&'(" <=<=<
' 8E$ 'aƒ10 9l( #) ^$ 'a10 '9 Z9> ) ; ') *+,ƒ- 'W
.[] „) %9) d
$I ;+, '!Xp ) ,-9)- ;>5() e !,- 6
G
.
"%) *+,ƒ-5 e(L "%) *+,-C : (>T? >> #) #- `" '*+,- !_") $ƒS
3
@
U
"%) *+,-9B (<F "%) *+,-/ e(<E "%) *+,-9( e(<< "%) *+,- e(<M
. & + (<G
___________________
1
- Aryl acetic acid
- Diclofenac sodium
3
- Oxicam
4
- Piroxicam
5
- Ampiroxicam
6
- Isoxicam
7
- Droxicam
8
- Cinnoxicam
9
- Meloxicam
2
٦
(L "%)
(<M "%)
(<< "%)
(<E "%)
(<F "%)
(<G "%)
`" '*+,- !_") $S +
٧
d
$ƒƒƒI 'ƒƒƒƒƒƒ-> ƒƒƒ9> 9ƒƒƒl( #ƒƒƒ) €5ƒƒƒ ƒƒƒX Zƒƒƒ9> 3@F '#ƒƒƒ ƒƒƒ*+ƒƒƒ,-
5$(ƒ ƒ*+ƒ,- '5ƒB 'ƒA+BCƒ2- 'ƒ"> %9ƒ(-ƒ> 0ƒ ƒ9> [ƒ- ' =B,-9)-m
.0 !( ;ƒƒ .9ƒƒ!ƒƒ ƒƒ (II)Aƒƒ %9ƒƒ ƒƒ) [ƒƒB$7 'ƒƒ*+ƒƒ,- A+BCƒƒ2- $Sƒƒ +ƒƒ .0 #(9<9- (II) A %9 #) #00 89: #) *+,- '01 ->
CH3
H
O
O
CH3
N
N
Cu
O
DMF
O
DMF N
CH3
S
N
CH3
S
O
N
O
O
N
S
O
N
H
H CH3
CH3
O
O
O
Cu
N
N
S
O
O
N
N
H
O
O
O
O
N
O
A '5B %9 ) [B$7 '*+,- A+BC2- $S +
ƒƒX Zƒƒ9> 3@ ƒƒ ƒƒ) ;$ƒƒ,70 'ƒƒ) *+ƒƒ,-/ !ƒƒ(" ƒƒ*+ƒƒ,- '90ƒƒS 9ƒƒ_? ;ƒƒ
ƒƒ/ ' ƒƒ\(/ …5ƒƒ #ƒƒ- ƒƒ #ƒƒ) '$ƒƒ,X TE$ƒƒ %ƒƒ( ƒƒ) ƒƒ !ƒƒ" ƒƒ^$ ƒƒ 5ƒƒ
!T0ƒƒƒ †9ƒƒƒ? ;ƒƒƒ(‡2 Dƒƒƒ
k9ƒƒƒS 'ƒƒƒ"> Vƒ ƒ7) ;ƒƒƒ .[4] ƒƒƒX ƒƒƒj %ƒƒƒ
`ƒƒƒK
:X! j !) 9 *+,-/
&'(") Q, OP (N
eƒƒ0)!ƒƒ qƒƒ0 Dƒƒ,> #ƒƒ- !0ƒƒ2) dƒƒ
$ ]ƒƒ )ƒƒ- ;$ƒƒ) *+ƒƒ,-/ ƒƒ
: (>T? #- , 50 '1 ! 8:9KS ' *+,-/ e; ) N? .
.[6] ;+,> .[U eG e.] %) 'f) ' '0&;/ f) %9S I 6
___________________
1
- Pfizer
- Pharmocological
2
٨
[@] d
$I .
[3] m ˆE0 eu>& e€9> >& ''2) % G
x
!29 #( eV e;9- '%H !0H '9B " ((-'X9B ((-[j9$ U
.[F]%9S
V-[B? S %& )- #) %9>! e*+,-/ ') -‰ ! 8:9KS ) N?
.- 50 V-Šj
&'(") R, ? OP (@
[] =W99) 'D$, z'90 ((-" VE0 [] ] 'm ;5X%9 '$+ S )- [4] ,-/9 `aO ,>- %9(? #) L$ 4
S O %9(? #) ; L$ *+,-/ ')- !+ e -‰ N
‹ Tj #- 9H%2
+> =2- #) ZrO22+ UO22+ eCu2+ (0 !(1( '%9 . ] 'm ;5X%9 '$+
#B2 %9 #E) $) Cu2+ #) T,0 *+,-/ 'Xd7$0 #$T #- 09! *+,-/ ) A+BC20& ( '(09/ = %9(? #) #-) 9<9B '%9 9_O .)! UO22+ ZrO22+
' rH *+,-/ e9 ; . 9S `aO ZrO22+ UO22+ 2O5 J (09! L$
.9! #(9<9- A '5B %9 #) #00# 89: #) '& X CO NH eOH
&'(") ,$*9 T (S
†9ƒƒ? ' ;ƒƒ e2ƒƒ) *+ƒƒ,-/ 'ƒƒ) %9ƒƒ>!ƒƒ #ƒƒ- 'ƒƒ !ƒƒ 'ƒƒ)- 9ƒƒ ƒƒ)
e!$ƒƒ9/ 'ƒƒƒƒ> eƒƒ eQƒƒS %9ƒƒ>!ƒƒ %& !T0ƒƒ †9ƒƒ? #ƒƒB2 #ƒƒ- ƒƒ !>ƒƒL$ !T0ƒƒ
.[6] ) *0 m 92,
___________________
1
- Rheumatoid arthritis
- Arthritis
3
- Leucemia
4
- Non pharmocological
5
- Photosensitizing
2
٩
†9ƒƒ? ƒ" '509ƒS e'ƒ$C/ 'ƒDƒƒS ƒ\ #ƒ) %9ƒ>!ƒ %& !T0ƒƒ †9ƒ? ;ƒ>Dƒ
#ƒB2 eNƒƒ? #ƒƒ) .ƒƒ- ƒƒ u!ƒƒ/ ƒƒ+0 9ƒƒH ;ƒƒ2 €%9ƒƒ,0 509$ƒƒ *(ƒƒ ƒƒ(02 [ƒƒB$7 !$ƒƒ9/
ƒƒ1 8ƒƒT? #ƒƒ) e9ƒƒ!ƒƒ dƒƒ$& 9ƒƒ0 ƒƒ)) ƒƒ9/ $ƒƒ) ƒƒ,O ƒƒ\ #ƒƒ) ƒƒ\( *+ƒƒ,-/
†ƒ" ;$ƒX ƒj 9ƒ!ƒ '9ƒ0 ƒ,O ƒ\ #ƒ) ƒ\( #ƒ- ƒ !ƒ #ƒB2 *+,-/
89ƒƒ: %$ƒƒ10 #ƒƒO0 k9ƒƒKS #ƒƒ) !$ƒƒ9/ 8"ƒƒI ƒƒ\ #ƒƒ) ƒƒ\( %& L$ƒƒ Aƒƒ/ dƒƒ$& 9ƒƒ0
#ƒ- ƒ((-!ƒ #ƒ:9> %ƒ2) #ƒ) %+ƒ5/ ƒ ;ƒ2 #ƒ) .9ƒ!ƒ e($ƒ, dƒ$& 9ƒ0 ) DE$, ˆ2> #'ƒƒ*ƒƒ- *5ƒƒ 89ƒƒ: ƒƒ((- '9ƒƒS dƒƒ$& 9ƒƒ0 ƒƒ) DE$ƒƒ, ˆƒƒ2> ;ƒƒ L$ƒƒ Aƒ/
.(20 L$ d$&I
&'(") *+ ,-. E=<=<
ƒƒƒ-> =ƒƒƒ ;ƒƒƒ>5() .[.] ƒƒƒ ƒƒƒ,- ' e ;ƒƒƒ>5() e !E$ƒƒƒ *+ƒƒƒ,-/
+ƒƒ> ;ƒƒ> '#ƒƒEBO =ƒƒ !ƒƒ05() '#ƒƒEBO =ƒƒ ƒƒ '#ƒƒEBO D$ƒƒ, =ƒƒ #ƒƒ- ƒƒ +ƒƒ$
'9ƒƒ_? Vƒƒ +ƒƒ$ =ƒƒ 'ƒƒ(%ƒƒ0 ;ƒƒ> %5ƒƒ() 'ƒƒ( %ƒƒ0 5ƒƒ() e;ƒƒ>5() .ƒƒ ƒƒ
ƒƒ 4 +ƒƒ *+ƒƒ,-/ ƒƒ #ƒƒ(
) $Sƒƒ .ƒƒ %Wƒƒ$0 9L9ƒƒ 'ƒƒD>ƒƒ$ ƒƒ
.[G] 9!
.[G] *+,-/ #(
) $S 4 +
.[.] 9! 6 + 50 *+,-/ 'aX2 'a10 ;(‡2
___________________
1
- Stone's Janson
- Epidermic necrosis
2
١٠
.[.]*+,-/ 'aX2 'a10 6 +
%0 . + #- 9H%2 #- [U] X l0 %9>! !>L$ !2 '$S *+,-/ ')
!090& * (<J "%) %9 Y * e(<I "%) ) * e(<H "%) #$,) * : (>T? >> #) (<K "%)
(<I "%)
(<H "%)
(<J "%)
(<K "%)
.[U]*+,-/ 8L$ !2 '$S . +
١١
y
9,-) exB/ eu%B e€*+,-/ : (>T? *+,-/ 1 '\> '*0 !S)
9,-' F eF $ 3 [%B$(9(& ;/) !,-] @ (@E) -> ; ‚/9& *0
.)! %Œ U %'> . e4 e -[F e6 e6]9B+!) & 3 > FλG
!10 L '9B) 89: #) 44/46@ !9+9 * ‫ و‬C15H13N3O4S !9+9 9 ) *+,-/
'9B) .) '9( '#j e'#B e!09 09> ! 9BT> L$ 9 NO „90 #) #$,) # 09! O Bj ;/ e%9$> e%9$ ($, 9) %) D"H %) *+,-/
EZE %& ;>/ #- !>L$ ''()89: ' *+,-/ .($, 9B^0 !)& 'Z^
(G +). ZZZ
O
O
O
O
CH3
S
S
CH3
N
H
N
O-
N
N
O
O-
N
N
H
O
EZE
ZZZ
.[@]*+,-/ ''(T>9: ;>/ G +
&'(") U4 F=<=<
e H ƒƒƒ$ !ƒƒƒ,- 6 ƒƒƒ$ 9ƒƒƒ!ƒƒƒB .F !H9ƒƒƒB7 *+ƒƒƒ,-/ 5$(ƒƒƒ 'ƒ ƒ)
%ƒƒ0 U +ƒƒ ƒƒ- 8ƒƒ<5 ƒƒ) %& 5$(ƒƒ #ƒƒ-) ƒƒ,- ' e 8Nƒƒ,-9)- 4 ;ƒƒ>5()
z#Bƒƒ,-9 Zƒƒ ƒƒ^> ;ƒƒB ƒƒ$!ƒƒB .F ;ƒƒ/9(& 9ƒƒ!ƒƒB 4FF (ƒƒ ƒƒ
ƒƒ YƒS ƒE> Zƒ9> ;ƒB !ƒ7) .9ƒ!ƒ Aƒ-N ?ƒ 8ƒ #ƒ) !9ƒ+9 ƒ)m 9ƒ_O
#ƒƒ- ƒƒ&!ƒ ƒƒ #ƒƒ) !ƒ10 Lƒƒ 'ƒƒ9B) e1ƒ& Zƒƒ^ V(ƒƒ- 9ƒB7 ƒƒ02j) % ƒƒj ƒ) .[6] - 9BT$ %,-' %& %9>!
___________________
1
- Pyroxycam
- Felden
3
- Piroflat
4
- Baxo
5
- Soxhlet
6
- Molecular Sieve
7
- Reflux
2
١٢
.
.[6] *+,-/ 5$( O U +
&'(") C,43 ; G=<=<
#ƒƒ) . !1$ƒƒ,) 9ƒƒBT> 'ƒƒ) L$ƒƒ 9ƒƒ NƒƒO ƒƒTj 9ƒƒBT> ?ƒƒ #ƒƒ) *+ƒƒ,-/ '9ƒƒB) *ƒƒ
ƒƒ\ '9ƒ( *ƒ !ƒX !09ƒ *ƒƒ !ƒX e%ƒ$B-' ƒ %9$ƒ ƒƒ(0 !ƒNƒO eƒ‘ %9ƒ(?
9ƒ #ƒ) '9ƒ( !09ƒ 'ƒ9B) !H9ƒB7 8$ƒƒ> ƒ %9ƒ$> #ƒ-!ƒO eƒ((-!
.09! '9( '9B) \ #) \( ZE ;<99> %5() .0&!
%9ƒƒ(? #ƒƒ) .ƒ0 !1$ƒƒ,) 5ƒƒ0 9ƒƒB) ƒƒ"TH #ƒƒ) ƒƒ0aX!ƒƒ ƒƒJ !ƒƒ$7 ƒƒ( 'ƒƒ*ƒƒ ƒƒ) #ƒ- !ƒ9$-
ƒ>9- 'ƒ#ƒB *ƒ #ƒ) %ƒ$B-' ƒ(09>!ƒ ƒ0 9ƒ '9ƒ( 89ƒ: #ƒ) #- !9B) e‘
___________________
1
- Polymorphism
١٣
'9ƒ( !09ƒ '9ƒB) *ƒ #ƒ- ;ƒ #ƒ9> ƒ #ƒ$+0 .09ƒ 9ƒBT$ '#ƒj 89ƒ: #) %,-'
89ƒƒ: #ƒƒ) 9ƒƒ ƒƒ #)ƒƒ !9ƒƒ+9% !0Wƒƒ 'ƒƒ09/ 9ƒ *+ƒƒ,-/ 'ƒƒ) #ƒƒ*ƒƒ !9ƒƒ+9;ƒƒ) !0Wƒƒ 'ƒƒ09/ #ƒƒ- !ƒƒO ƒƒ0 9ƒƒ N−H···N O−H···O 'ƒƒ09/
O−H···O !9ƒƒ+9;ƒƒ) 'ƒƒ09/ !ƒƒ0 !09ƒƒ 'ƒƒ9ƒƒB) 'ƒƒ) O−H···N ƒƒ09/ !ƒƒ0 '9ƒƒ(
.[3] ()!
.09! *+,-/ '9( !09 * @ + .[3] *+,-/ '9( !09 '* @ +
8 ,-. > &'(") 080/# V/ 0/ H=<=<
.(ƒƒ)!ƒƒ ZZZ EZE ƒƒ%& ;>ƒƒ/ #ƒƒ- ƒƒ !>ƒƒL$ 'ƒƒ'ƒƒ()89ƒƒ: ' *+ƒƒ,-/
=ƒƒ 89ƒƒ: #ƒƒ) !Bƒƒ/ N rƒƒH ƒƒ01 ƒƒ EZE Vƒƒ& ' *+ƒƒ,-/ !ƒƒ‘(S *ƒƒ f
‹ 9ƒƒ:
.[@] 9! K$ l09 '5B %9 #) #00=> 01
'ƒƒ& ƒƒX O !Bƒƒ/ N rƒƒH #ƒƒ00 ƒƒ01 =ƒƒ 89ƒƒ: #ƒƒ) ZZZ *ƒƒ *+ƒƒ,-/
9ƒ !09ƒ0& 9ƒ( ƒO Dƒ !ƒ‘(S ƒO Dƒ ZZZ *ƒ #ƒX .9ƒ!ƒ #ƒ(9<9- '5ƒB %9 #)
ƒƒX #ƒƒ) 9ƒƒ) O ;ƒƒ) #ƒƒ- !9ƒƒ+9% !0Wƒƒ ƒƒ09/ ƒƒ\ ƒƒ #ƒƒ) !09ƒƒ0& 9ƒƒ( ƒƒO ƒƒ !ƒ0 'ƒ/ %& ƒ ƒ '$ƒ) 'ƒ/ ' eƒ&!ƒ 9ƒ #ƒ) 'ƒ& ƒX NH ƒ,-
.[U] !9+9% !0W 09/ \ J +> !>V '#EBO +> ƒƒO 9ƒƒ!ƒƒ #ƒƒlON #ƒƒ- 9ƒƒH%ƒƒ2 .9ƒƒ!ƒƒ ƒƒ ZZZ EZE Vƒƒ& 3 +ƒƒ ƒƒ09/ ƒƒ\ 'ƒƒ ƒƒ( !ƒƒ_ 'ƒƒX ƒƒ
eC―N C―C 'ƒƒ09/ 9ƒƒO VSƒƒ !09ƒƒ0& 9ƒƒ(
١٤
aƒƒƒ/%ƒƒƒ+ 'ƒƒƒ& ƒƒX NH !Bƒƒƒ,- ƒƒƒX #ƒƒƒ) 9ƒƒ) O ;ƒƒƒ) !9ƒƒƒ+9% !0Wƒƒ
.(-!
*+,-/ 9+9 VS > 'I %9>/ = `aO ZZZ #) EZE '()89: o> ')
% !- & 9 #) ZZZ '()89: V& 9 *\0 C(3)―C(14) C(14)―N(16) 9O
O(17) rH % #(9<9- 2$O eEZE '()89: .(4 +) 9 *\0 O(15) N(1) rH
9 e#\$0 &!20 9 #) N(16) O(17) ;) '9j !0W 09/ 0 9O(15)
.(3 +) X! 89: !B/ N rH % #(9<9- EZE '()89:
O
O
S
CH3
O
H
N
N
N
O
O
S
H
N
-H+
N
OH
O
CH3
S
CH3
N
O-
N
O
O-
O
O
N
N
H
.[@] %& ''()89: T> *+,-/ % #09>/ 3 +
&'(") !" ,-. E=<
'5ƒƒB 'ƒƒ%9ƒƒ #ƒƒ) %ƒƒ #ƒƒ(9<9- 'ƒƒ) [ƒƒB$7 D>ƒƒ$ ƒƒ"j9 Vƒƒ ' *+ƒƒ,-/ #ƒƒX
ƒƒ2? #ƒƒ00 #ƒƒ 89ƒƒ: #ƒƒ) ‘-ƒƒO *+ƒƒ,-/ e%& ƒƒ #$S(ƒƒ 'ƒƒA+BCƒƒ2- eƒƒ [ƒƒB$7
!09ƒƒ0&' ƒƒ!ƒƒ- =ƒƒ 89ƒƒ: #ƒƒ) *+ƒƒ,-/ %& #ƒƒ- Sn(IV) !ƒƒ,+BC2- ƒƒO ;ƒƒ .ƒ (-!ƒƒ
.[F] 9! e(-! 2? #00 #
e=ƒƒ ƒ01 =ƒ 89ƒƒ: #ƒ) ƒ09>!ƒƒ 9ƒS 'ƒA+BCƒƒ2- *+ƒ,-/ eƒ$
) 'ƒƒ()#$ƒ =ƒ .20 2? #00#

 Download  Report

Paperzz.com

Your Paperzz

© Copyright 2025 Paperzz