FIG. 1. In vitro drug release data. A, Cumulative release of TA (µg) versus time (days)
for Medpor implants coated with 15%PVA and low, medium and high doses of TA
(5%TA, 25%TA and 50%TA, respectively. B, Release rates of TA (µg/day) for same
implants.
TABLE 1. Experimental design
Rabbit
Right lower eyelid
1–3
Dissection; skin incision
4
Dissection; conjunctival incision
5
pPE alone
6
pPE coated with PVA, no TA
7
pPE + PVA/low TA overlay,
8
Dissection; conjunctival incision
Left lower eyelid
No surgery
pPE coated with PVA/low TA
pPE coated with PVA/low TA
pPE coated with PVA/low TA
pPE coated with PVA/low TA
pPE coated with
PVA/intermediate TA
Group 3: intermediate-dose TA
9
pPE alone
pPE coated with
PVA/intermediate TA
Group 3: intermediate-dose TA
10
pPE coated with PVA, no TA
pPE coated with
PVA/intermediate TA
Group 3: intermediate-dose TA
11
pPE + PVA/intermediate TA
pPE coated with
overlay
PVA/intermediate TA
Group 4: high-dose TA
12
Dissection; conjunctival incision
pPE coated with PVA/high TA
Group 4: high-dose TA
13
pPE alone
pPE coated with PVA/high TA
Group 4: high-dose TA
14
pPE coated with PVA, no TA
pPE coated with PVA/high TA
Group 4: high-dose TA
15
pPE + PVA/high TA overlay
pPE coated with PVA/high TA
pPE, porous polyethylene implant; TA, triamcinolone acetonide; PVA, polyvinyl alcohol.
Group 1: dissection alone
Group 2: low-dose TA
Group 2: low-dose TA
Group 2: low-dose TA
Group 2: low-dose TA
Group 3: intermediate-dose TA
TABLE 2. Histologic data
Rabbit
Fibrovascular
Anterior
Posterior
eyelid
Implant
ingrowth
Inflammation capsule (µm) capsule (µm)
9R
pPE
Extensive
Moderate
265
87.5
13R
pPE
Extensive
Moderate
207.5
110
10R
pPE/PVA
None
Moderate
87.5
110
5L
pPE/PVA/low TA
None
Mild
167.5
112.5
8L
pPE/PVA/intermediate TA
Small
Mild
82.5
187.5
9L
pPE/PVA/intermediate TA
None
Mild
82.5
80
11L
pPE/PVA/intermediate TA
Small
Mild
110
80
14L
pPE/PVA/high TA
None
None
42.5
35
7R
PVA/low TA overlay
Moderate
Severe
125
120
R, right eyelid; L, left eyelid; pPE, porous polyethylene implant; TA, triamcinolone acetonide;
PVA, polyvinyl alcohol.