Synaptic Function
Antibodies
The functional unit of the nervous system is the
neuron, which relays electrical and chemical
signals to other neurons at junctions known
as the neural synapse. The differentiated
mammalian central nervous system is estimated
to contain at least 100 billion neurons, which
communicate with each other through multiple
synaptic connections. Neurons are designed to
transmit these signals through specialized cellular
projections, axons and dendrites, that extend
far from the cell body. The neural synapse most
often occurs between the axon of one neuron
and the dendrites of another and is composed
of hundreds of proteins that function together
to coordinate the exquisitely tuned signals
that are the physical basis for higher nervous
system functions, such as cognition, memory, or
movement.
Many distinct types of neural synapses exist that
relay some of the hundreds of known chemical
signals, termed neurotransmitters, from one
neuron to another, or form a direct contact
and thus are categorized as electrical synapses.
Synapses adapt over time and can weaken or
strengthen in response to a number of factors, a
phenomenon which is termed neural plasticity.
Neurodegenerative diseases, such as Alzheimer’s
and Parkinson’s, display a loss of synaptic
function and a subsequent degradation of these
structures. This degeneration occurs more
prominently at particular locations in the central
nervous system for particular neurodegenerative
diseases, such as the substantia nigra for
Parkinson’s disease, which is highly enriched
in synapses that transmit the neurotransmitter
dopamine. Investigation into the mechanisms
that lead to dysfunction and synaptic loss, with
the support of BioLegend reagents, may provide
new avenues for preventative or therapeutic
intervention.
Find an extensive selection of research products at:
antibody.biolegend.com
Toll-Free Tel (US & Canada): 1.800.223.0796
Tel:1.781.915.5200
Email: [email protected]
antibody.biolegend.com
07-0097-00
World-Class Quality | Superior Customer Support | Outstanding Value
Synaptic Function Antibodies
For the latest product updates and product information, visit: antibody.biolegend.com
Monoamine Neurotransmitter Biology
nACh Receptors
Specificity
Clone
Reactivity Application(s)
Cat. No.
DOPA Decarboxylase
Dopamine Transporter
(C-terminal)
Dopamine Transporter
(Extracellular)
pS40 Tyrosine Hydroxylase
Polyclonal
Mammal
WB, DB
PRB-323P
Specificity
Clone
nAChRα1
61
Reactivity
PRB-330P
nAChRα1/α3/α5
210
PRB-502P
nAChRα4
299
IHC
SIG-3226
WB, DB, IHC
WB, IHC, ELISA
WB, IHC
PSH-327P
PRB-515P
MMS-5210
nAChRα7
nAChRα7
nAChRβ2
nAChRγ
319
306
270
66
Hu, Ms,
Torpedo,
Electrophorus
Ckn, Dog, Hu,
Rodent
Ckn, Hu,
Rodent
Ckn, Hu, Rat
Ckn, Hu, Rat
Ckn, Rodent
Cow, Hu
Polyclonal
Hu, Monkey
WB, DB, IHC
PRB-324P
Polyclonal
Hu, Monkey
WB, DB, IHC
Polyclonal
WB, IHC, ELISA, IP
Serotonin
Polyclonal
Tryptophan Hydroxylase
Tyrosine Hydroxylase
Tyrosine Hydroxylase
Polyclonal
Polyclonal
2/40/15
Rat
Hu, Rat, Dog,
Primate
Hu, Rat
Mammal
Hu, Ms, Rat
Specificity
Clone
Reactivity Application(s)
Cat. No.
ADAM-22 (Cytoplasmic)
ADAM-22 (Extracellular)
IP3 Receptor Type 1
KCC2
KCNA5
LRP4
Notch1
Notch1
p75NTR
p75NTR
p75NTR
Sodium Calcium Exchanger 1
N46/30
N57/2
L24/18
N1/12
2D10.D6
N207/27
mN1A
N253/32
NGFR5
Polyclonal
Polyclonal
6H2
Hu, Ms, Rat
Hu, Ms, Rat
Hu, Ms, Rat
Hu, Ms, Rat
Hu, Rat
Ms, Rat
Hu, Ms
Ms, Rat
Hu
Hu, Rodent
Hu
Mammal
MMS-5124
MMS-5125
MMS-5151
MMS-5241
MMS-5035
MMS-5154
MMS-5097
MMS-5169
MMS-5228
PRB-602C
PRB-608P
MMS-318P
Postsynaptic Density Proteins
Application(s)
Cat. No.
IF, IP
MRT-607R
WB, IF, IP
MRT-609R
IF, IP
MRT-613R
WB, IF, IP
WB, IF, IHC, IP
WB, IF, IP
WB, IF, IP
MRT-629R
MMS-627R
MRT-639R
MRT-643R
Specificity
Clone
GluN1
GluN2A
GluN2A
GluN2B
GluN2B
N308/48
N327/95
N327A/38
N59/36
N59/20
Reactivity
Application(s)
Cat. No.
Rat
Hu, Ms, Rat
Hu, Ms, Rat
Hu, Ms, Rat
Hu, Ms, Rat
WB, IHC
WB
WB
WB, IHC
WB
MMS-5145
MMS-5146
MMS-5147
MMS-5148
MMS-5149
NMDA Receptors
Presynaptic Receptors
WB, IHC
WB
WB, IHC
WB, IHC
WB, IHC
WB
WB
WB, IHC
WB, IHC
WB, IP, IF, IHC
WB, IHC
WB
SNARE Complex and Vesicular Proteins
Specificity
Clone
Reactivity
Application(s)
Cat. No.
Ankyrin-B
N105/13
WB, IHC
MMS-5246
Ankyrin-B
N105/17
WB, IHC
MMS-5247
Chapsyn-110
Chapsyn-110
Pan-MAGUK
PSD-95
PSD-95
SAP102
SAP97
SAPAP1
Pan-SAPAP
N18/28
N18/30
K28/86
K28/43
K28/74
N19/2
K64/15
N238/31
N127/31
Hu, Ms, Rat
Hu, Ms, Rat,
Worm
Hu, Ms, Rat
Hu, Ms, Rat
Hu, Ms, Rat
Hu, Ms, Rat
Hu, Ms, Rat
Hu, Ms, Rat
Hu, Ms, Rat
Hu, Ms, Rat
Hu, Ms, Rat
WB, IHC
WB, IHC
WB, IHC
WB, IHC, ICC
WB, IHC, ICC
WB
WB
WB
WB
MMS-5129
MMS-5244
MMS-5173
MMS-5182
MMS-5183
MMS-5186
MMS-5187
MMS-5188
MMS-5176
Specificity
Clone
Reactivity Application(s)
Cat. No.
Clathrin Heavy Chain
TD.1
WB, IF
MMS-427P
Clathrin Light Chain
CON.1
WB, IP, IF
MMS-423P
Doc2b
SNAP-25
N150/21
SMI 81
WB
WB, IHC, ELISA, ICC
MMS-5250
SMI-81R
SNAP-25
SP12
WB, IHC
MMS-614P
Receptor Endocytosis Proteins
Stonin-2
SVOP
Synapsin I
Synaptobrevin
Synaptobrevin
N346/9
N356/9
Polyclonal
SP10
SP11
WB, ICC, IHC
WB, IHC
WB, IP, ICC, ELISA
WB, ICC, ELISA
WB, ICC, ELISA
MMS-5270
MMS-5195
PRB-516P
MMS-616R
MMS-636P
Specificity
Clone
Reactivity
Application(s)
Cat. No.
Dynamin-1
PICK1
Thorase
D5
L20/8
N125/10
Hu, Ms, Rat
Hu, Ms, Rat
Hu, Ms, Rat
WB, IHC
WB
WB, IHC
MMS-5122
MMS-5179
MMS-5155
Synaptophysin
SP17
WB, ICC, ELISA
MMS-618R
Synaptic Cell Adhesion Molecules
Synaptophysin
Synaptophysin
SY38
Polyclonal
IHC
IHC
SIG-3260
SIG-3261
Specificity
Clone
Reactivity
Application(s)
Cat. No.
Syntaxin
SP8
IHC
MMS-619P
Synaptotagmin-12
VGLUT1
VGLUT2
N277/7
N28/9
N29/29
Hu, Cow
Mammal,
Yeast
Hu, Ms, Rat
Mammal
Hu, Ms, Rat,
Pig, Cat
Hu, Ms, Rat
Ms, Rat
Mammal
Mammal
Hu, Pig, Cat
Hu, Rodent,
Pig
Hu, Ms, Dog
Hu
Hu, Rodent,
Pig
Ms, Rat
Hu, Ms, Rat
Ms, Rat
WB, IHC
WB, IHC
WB
MMS-5197
MMS-5245
MMS-5206
AMIGO-1 (L86/33)
AMIGO-1 (L86/36)
γ-Protocadherin A1
γ-Protocadherin A3
γ-Protocadherin B2
L1 (CD171)
L1 NCAM
Neuroligin-1
NrCAM
L86/33
L86/36
N159/5
N144/32
N148/30
14.1
74-5H7
N97A/31
N343/26
IHC
WB, ICC, IHC
WB
WB, IHC
WB
IHC
WB, IP, IHC
WB, IHC
WB, ICC
MMS-5126
MMS-5271
MMS-5172
MMS-5171
MMS-5140
SIG-3911
MMS-172R
MMS-5165
MMS-5267
p120 Catenin
2B12
WB
MMS-5040
SALM2
SynCAM4
N52B/27
N244/5
Hu, Ms, Rat
Hu, Ms, Rat
Ms
Ms
Ms
Hu
Mammal, Ckn
Hu, Ms, Rat
Hu, Ms, Rat
Hu, Ms, Rat,
Hmr, Ckn
Hu, Ms, Rat
Hu, Ms, Rat
WB, IHC
WB
MMS-5184
MMS-5257
Specificity
Clone
Reactivity
Application(s)
Cat. No.
CaMKIV
CASK
CnA1
Pan-GRK
pS3 Cofilin-1
pT286 CaMKII
RGS14
RhoG
WAVE1
3E5.E8
K56A/50
2E2.D11
N145/20
3E8.A9
Polyclonal
N133/21
1F3 B3 E5
K91/36
Hu, Ms, Rat
Hu, Ms, Rat
Hu, Ms, Rat
Hu, Ms, Rat
Hu, Ms
Rat
Hu, Ms, Rat
Hu, Ms, Rat
Hu, Ms, Rat
WB
WB
WB, IHC
WB
WB, IHC, ICC
WB, IP, IHC, ELISA
WB, IHC
WB, IHC
WB, IHC
MMS-5081
MMS-5128
MMS-5123
MMS-5249
MMS-5080
PRB-506P
MMS-5248
MMS-5032
MMS-5208
AMPA Receptors and Receptor Regulatory Proteins
Specificity
Clone
Reactivity Application(s)
Cat. No.
GluR1
GluR2
pS831 GluR1
pS845 GluR1
SynDIG3
TARP γ2
N355/1
L21/32
Polyclonal
Polyclonal
N160/21
N245/1
Ms, Rat
Hu, Ms, Rat
Rat
Rat
Ms
Hu, Ms, Rat
MMS-5143
MMS-5144
PRB-507P
PRB-509P
MMS-5203
MMS-5255
WB, IHC
WB, IHC, ICC
WB, IHC, IP, ELISA
WB, IHC, IP, ELISA
WB, IHC
ICC
GABA Receptors
Specificity
Clone
Reactivity Application(s)
Cat. No.
GABAARα1 (Cytoplasmic)
GABAARα4 (Cytoplasmic)
GABAARα4 (N-terminal)
GABAARα6
N95/35
Polyclonal
Polyclonal
Polyclonal
WB
WB, IP
WB, IP
WB, DB
MMS-5132
PRB-549P
PRB-548P
PRB-559C
GABAARβ2 (C-terminal)
Polyclonal
WB
PRB-596P
GABAARβ3
GABABR1
GABABR2
GABABR2
N87/25
N93A/49
N81/2
N81/37
Hu, Ms, Rat
Rat
Rat
Hu, Ms, Rat
Cow, Hu, Ms,
Rat
Hu, Ms, Rat
Hu, Ms, Rat
Hu, Ms, Rat
Hu, Ms, Rat
WB, IHC
WB, IHC
WB, IHC
WB
MMS-5134
MMS-5136
MMS-5137
MMS-5138
Ckn = Chicken
Hmr = Hamster
Hu = Human
Ms = Mouse
Synaptic Enzymes
DB = Dot Blot ICC = Immunocytochemistry IF = Immunofluorescence
IHC = Immunohistochemistry IP = Immunoprecipitation
WB = Western Blot/Immunoblot
Toll-Free Tel (US & Canada): 1.800.223.0796
Tel:1.781.915.5200
Email: [email protected]
antibody.biolegend.com
07-0097-00
World-Class Quality | Superior Customer Support | Outstanding Value